Pancreatic Cancer 3 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Pancreatic Cancer 3

MalaCards integrated aliases for Pancreatic Cancer 3:

Name: Pancreatic Cancer 3 ⁵⁷ ⁷⁵ ²⁹ ⁶

Pancreatic Cancer, Susceptibility to, 3 ⁵⁷ ¹³

Pnca3 ⁵⁷ ⁷⁵

Cancer, Pancreatic, Susceptibility to, Type 3 ⁴⁰

Classifications:

MalaCards categories:
Global: Genetic diseases Cancer diseases Rare diseases
Anatomical: Endocrine diseases Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM ⁵⁷ 613348

MedGen ⁴² C3150547

MeSH ⁴⁴ D010190

Sources

Summaries for Pancreatic Cancer 3

UniProtKB/Swiss-Prot : ⁷⁵ Pancreatic cancer 3: A malignant neoplasm of the pancreas. Tumors can arise from both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue.

MalaCards based summary : Pancreatic Cancer 3, also known as pancreatic cancer, susceptibility to, 3, is related to fanconi anemia, complementation group n. An important gene associated with Pancreatic Cancer 3 is PALB2 (Partner And Localizer Of BRCA2). Affiliated tissues include pancreas.

Description from OMIM: 613348

Sources

Related Diseases for Pancreatic Cancer 3

Diseases in the Pancreatic Cancer family:

Pancreatic Cancer 1	Pancreatic Cancer 2
Pancreatic Cancer 3	Pancreatic Cancer 4

Diseases related to Pancreatic Cancer 3 via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	fanconi anemia, complementation group n	9.0	DCTN5 PALB2

Sources

Symptoms & Phenotypes for Pancreatic Cancer 3

Clinical features from OMIM:

613348

Sources

Drugs & Therapeutics for Pancreatic Cancer 3

Search Clinical Trials , NIH Clinical Center for Pancreatic Cancer 3

Sources

Genetic Tests for Pancreatic Cancer 3

Genetic tests related to Pancreatic Cancer 3:

#	Genetic test	Affiliating Genes
1	Pancreatic Cancer 3 ²⁹	PALB2

Sources

Anatomical Context for Pancreatic Cancer 3

MalaCards organs/tissues related to Pancreatic Cancer 3:

⁴¹

Pancreas

Sources

Publications for Pancreatic Cancer 3

Sources

Genes for Pancreatic Cancer 3

Genes related to Pancreatic Cancer 3 (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	PALB2	Partner And Localizer Of BRCA2	Protein Coding	1103.56	Molecular basis known ⁵⁷ Pathogenic ⁶ Genetic Tests ²⁹ Susceptibility factor ⁵⁷ Pathogenic/Likely pathogenic ⁶ GeneCards inferred via : Disorders Variants (show sections)	19264984
2	DCTN5	Dynactin Subunit 5	Protein Coding	17.35	GeneCards inferred via : Variants (show sections)

Sources

Variations for Pancreatic Cancer 3

ClinVar genetic disease variations for Pancreatic Cancer 3:

⁶

(show all 28)

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	PALB2	NM_024675.3(PALB2): c.3549C> G (p.Tyr1183Ter)	single nucleotide variant	Pathogenic/Likely pathogenic,risk factor	rs118203998	GRCh37	Chromosome 16, 23614792: 23614792
2	PALB2	NM_024675.3(PALB2): c.3549C> G (p.Tyr1183Ter)	single nucleotide variant	Pathogenic/Likely pathogenic,risk factor	rs118203998	GRCh38	Chromosome 16, 23603471: 23603471
3	PALB2	NM_024675.3(PALB2): c.1027C> T (p.Gln343Ter)	single nucleotide variant	Pathogenic	rs180177097	GRCh38	Chromosome 16, 23635519: 23635519
4	PALB2	NM_024675.3(PALB2): c.1027C> T (p.Gln343Ter)	single nucleotide variant	Pathogenic	rs180177097	GRCh37	Chromosome 16, 23646840: 23646840
5	PALB2	NM_024675.3(PALB2): c.1314delA (p.Phe440Leufs)	deletion	Pathogenic	rs515726065	GRCh38	Chromosome 16, 23635232: 23635232
6	PALB2	NM_024675.3(PALB2): c.1314delA (p.Phe440Leufs)	deletion	Pathogenic	rs515726065	GRCh37	Chromosome 16, 23646553: 23646553
7	PALB2	NM_024675.3(PALB2): c.172_175delTTGT (p.Gln60Argfs)	deletion	risk factor	rs180177143	GRCh38	Chromosome 16, 23637886: 23637889
8	PALB2	NM_024675.3(PALB2): c.172_175delTTGT (p.Gln60Argfs)	deletion	risk factor	rs180177143	GRCh37	Chromosome 16, 23649207: 23649210
9	PALB2	PALB2: c.2515-1G> T	single nucleotide variant	Pathogenic/Likely pathogenic,risk factor	rs587776417	GRCh38	Chromosome 16, 23629276: 23629276
10	PALB2	PALB2: c.2515-1G> T	single nucleotide variant	Pathogenic/Likely pathogenic,risk factor	rs587776417	GRCh37	Chromosome 16, 23640597: 23640597
11	PALB2	NM_024675.3(PALB2): c.3116delA (p.Asn1039Ilefs)	deletion	Pathogenic/Likely pathogenic,risk factor	rs180177133	GRCh38	Chromosome 16, 23614089: 23614089
12	PALB2	NM_024675.3(PALB2): c.3116delA (p.Asn1039Ilefs)	deletion	Pathogenic/Likely pathogenic,risk factor	rs180177133	GRCh37	Chromosome 16, 23625410: 23625410
13	PALB2	PALB2: c.3202-?_*297del (p.Gly1068_Ser1186delins45)	deletion	Pathogenic		GRCh38	Chromosome 16, 23603162: 23608012
14	PALB2	PALB2: c.3202-?_*297del (p.Gly1068_Ser1186delins45)	deletion	Pathogenic		GRCh37	Chromosome 16, 23614483: 23619333
15	PALB2	NM_024675.3(PALB2): c.3256C> T (p.Arg1086Ter)	single nucleotide variant	Pathogenic/Likely pathogenic,risk factor	rs587776527	GRCh38	Chromosome 16, 23607958: 23607958
16	PALB2	NM_024675.3(PALB2): c.3256C> T (p.Arg1086Ter)	single nucleotide variant	Pathogenic/Likely pathogenic,risk factor	rs587776527	GRCh37	Chromosome 16, 23619279: 23619279
17	PALB2	NM_024675.3(PALB2): c.3497delG (p.Gly1166Valfs)	deletion	Pathogenic	rs180177138	GRCh38	Chromosome 16, 23603523: 23603523
18	PALB2	NM_024675.3(PALB2): c.3497delG (p.Gly1166Valfs)	deletion	Pathogenic	rs180177138	GRCh37	Chromosome 16, 23614844: 23614844
19	PALB2	NM_024675.3(PALB2): c.509_510delGA (p.Arg170Ilefs)	deletion	Pathogenic	rs515726123	GRCh38	Chromosome 16, 23636036: 23636037
20	PALB2	NM_024675.3(PALB2): c.509_510delGA (p.Arg170Ilefs)	deletion	Pathogenic	rs515726123	GRCh37	Chromosome 16, 23647357: 23647358
21	PALB2	NM_024675.3(PALB2): c.72delG (p.Arg26Glyfs)	deletion	Pathogenic	rs180177142	GRCh38	Chromosome 16, 23638106: 23638106
22	PALB2	NM_024675.3(PALB2): c.72delG (p.Arg26Glyfs)	deletion	Pathogenic	rs180177142	GRCh37	Chromosome 16, 23649427: 23649427
23	PALB2	NM_024675.3(PALB2): c.757_758delCT (p.Leu253Ilefs)	deletion	Pathogenic	rs180177092	GRCh38	Chromosome 16, 23635788: 23635789
24	PALB2	NM_024675.3(PALB2): c.757_758delCT (p.Leu253Ilefs)	deletion	Pathogenic	rs180177092	GRCh37	Chromosome 16, 23647109: 23647110
25	PALB2	NM_024675.3(PALB2): c.1240C> T (p.Arg414Ter)	single nucleotide variant	Pathogenic	rs180177100	GRCh38	Chromosome 16, 23635306: 23635306
26	PALB2	NM_024675.3(PALB2): c.1240C> T (p.Arg414Ter)	single nucleotide variant	Pathogenic	rs180177100	GRCh37	Chromosome 16, 23646627: 23646627
27	PALB2	NM_024675.3(PALB2): c.3549C> A (p.Tyr1183Ter)	single nucleotide variant	Pathogenic	rs118203998	GRCh38	Chromosome 16, 23603471: 23603471
28	PALB2	NM_024675.3(PALB2): c.3549C> A (p.Tyr1183Ter)	single nucleotide variant	Pathogenic	rs118203998	GRCh37	Chromosome 16, 23614792: 23614792

Sources

Expression for Pancreatic Cancer 3

Search GEO for disease gene expression data for Pancreatic Cancer 3.

Sources

Pathways for Pancreatic Cancer 3

Sources

GO Terms for Pancreatic Cancer 3

Sources

Sources for Pancreatic Cancer 3

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia