MCID: PNC095
MIFTS: 15

Pancreatic Cancer 3

Categories: Genetic diseases, Endocrine diseases, Cancer diseases, Rare diseases, Gastrointestinal diseases

Aliases & Classifications for Pancreatic Cancer 3

MalaCards integrated aliases for Pancreatic Cancer 3:

Name: Pancreatic Cancer 3 57 75 29 6
Pancreatic Cancer, Susceptibility to, 3 57 13
Pnca3 57 75
Cancer, Pancreatic, Susceptibility to, Type 3 40

Classifications:



External Ids:

OMIM 57 613348
MedGen 42 C3150547
MeSH 44 D010190

Summaries for Pancreatic Cancer 3

UniProtKB/Swiss-Prot : 75 Pancreatic cancer 3: A malignant neoplasm of the pancreas. Tumors can arise from both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue.

MalaCards based summary : Pancreatic Cancer 3, also known as pancreatic cancer, susceptibility to, 3, is related to fanconi anemia, complementation group n. An important gene associated with Pancreatic Cancer 3 is PALB2 (Partner And Localizer Of BRCA2). Affiliated tissues include pancreas.

Description from OMIM: 613348

Related Diseases for Pancreatic Cancer 3

Diseases in the Pancreatic Cancer family:

Pancreatic Cancer 1 Pancreatic Cancer 2
Pancreatic Cancer 3 Pancreatic Cancer 4

Diseases related to Pancreatic Cancer 3 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 fanconi anemia, complementation group n 9.0 DCTN5 PALB2

Symptoms & Phenotypes for Pancreatic Cancer 3

Clinical features from OMIM:

613348

Drugs & Therapeutics for Pancreatic Cancer 3

Search Clinical Trials , NIH Clinical Center for Pancreatic Cancer 3

Genetic Tests for Pancreatic Cancer 3

Genetic tests related to Pancreatic Cancer 3:

# Genetic test Affiliating Genes
1 Pancreatic Cancer 3 29 PALB2

Anatomical Context for Pancreatic Cancer 3

MalaCards organs/tissues related to Pancreatic Cancer 3:

41
Pancreas

Publications for Pancreatic Cancer 3

Variations for Pancreatic Cancer 3

ClinVar genetic disease variations for Pancreatic Cancer 3:

6
(show all 28)
# Gene Variation Type Significance SNP ID Assembly Location
1 PALB2 NM_024675.3(PALB2): c.3549C> G (p.Tyr1183Ter) single nucleotide variant Pathogenic/Likely pathogenic,risk factor rs118203998 GRCh37 Chromosome 16, 23614792: 23614792
2 PALB2 NM_024675.3(PALB2): c.3549C> G (p.Tyr1183Ter) single nucleotide variant Pathogenic/Likely pathogenic,risk factor rs118203998 GRCh38 Chromosome 16, 23603471: 23603471
3 PALB2 NM_024675.3(PALB2): c.1027C> T (p.Gln343Ter) single nucleotide variant Pathogenic rs180177097 GRCh38 Chromosome 16, 23635519: 23635519
4 PALB2 NM_024675.3(PALB2): c.1027C> T (p.Gln343Ter) single nucleotide variant Pathogenic rs180177097 GRCh37 Chromosome 16, 23646840: 23646840
5 PALB2 NM_024675.3(PALB2): c.1314delA (p.Phe440Leufs) deletion Pathogenic rs515726065 GRCh38 Chromosome 16, 23635232: 23635232
6 PALB2 NM_024675.3(PALB2): c.1314delA (p.Phe440Leufs) deletion Pathogenic rs515726065 GRCh37 Chromosome 16, 23646553: 23646553
7 PALB2 NM_024675.3(PALB2): c.172_175delTTGT (p.Gln60Argfs) deletion risk factor rs180177143 GRCh38 Chromosome 16, 23637886: 23637889
8 PALB2 NM_024675.3(PALB2): c.172_175delTTGT (p.Gln60Argfs) deletion risk factor rs180177143 GRCh37 Chromosome 16, 23649207: 23649210
9 PALB2 PALB2: c.2515-1G> T single nucleotide variant Pathogenic/Likely pathogenic,risk factor rs587776417 GRCh38 Chromosome 16, 23629276: 23629276
10 PALB2 PALB2: c.2515-1G> T single nucleotide variant Pathogenic/Likely pathogenic,risk factor rs587776417 GRCh37 Chromosome 16, 23640597: 23640597
11 PALB2 NM_024675.3(PALB2): c.3116delA (p.Asn1039Ilefs) deletion Pathogenic/Likely pathogenic,risk factor rs180177133 GRCh38 Chromosome 16, 23614089: 23614089
12 PALB2 NM_024675.3(PALB2): c.3116delA (p.Asn1039Ilefs) deletion Pathogenic/Likely pathogenic,risk factor rs180177133 GRCh37 Chromosome 16, 23625410: 23625410
13 PALB2 PALB2: c.3202-?_*297del (p.Gly1068_Ser1186delins45) deletion Pathogenic GRCh38 Chromosome 16, 23603162: 23608012
14 PALB2 PALB2: c.3202-?_*297del (p.Gly1068_Ser1186delins45) deletion Pathogenic GRCh37 Chromosome 16, 23614483: 23619333
15 PALB2 NM_024675.3(PALB2): c.3256C> T (p.Arg1086Ter) single nucleotide variant Pathogenic/Likely pathogenic,risk factor rs587776527 GRCh38 Chromosome 16, 23607958: 23607958
16 PALB2 NM_024675.3(PALB2): c.3256C> T (p.Arg1086Ter) single nucleotide variant Pathogenic/Likely pathogenic,risk factor rs587776527 GRCh37 Chromosome 16, 23619279: 23619279
17 PALB2 NM_024675.3(PALB2): c.3497delG (p.Gly1166Valfs) deletion Pathogenic rs180177138 GRCh38 Chromosome 16, 23603523: 23603523
18 PALB2 NM_024675.3(PALB2): c.3497delG (p.Gly1166Valfs) deletion Pathogenic rs180177138 GRCh37 Chromosome 16, 23614844: 23614844
19 PALB2 NM_024675.3(PALB2): c.509_510delGA (p.Arg170Ilefs) deletion Pathogenic rs515726123 GRCh38 Chromosome 16, 23636036: 23636037
20 PALB2 NM_024675.3(PALB2): c.509_510delGA (p.Arg170Ilefs) deletion Pathogenic rs515726123 GRCh37 Chromosome 16, 23647357: 23647358
21 PALB2 NM_024675.3(PALB2): c.72delG (p.Arg26Glyfs) deletion Pathogenic rs180177142 GRCh38 Chromosome 16, 23638106: 23638106
22 PALB2 NM_024675.3(PALB2): c.72delG (p.Arg26Glyfs) deletion Pathogenic rs180177142 GRCh37 Chromosome 16, 23649427: 23649427
23 PALB2 NM_024675.3(PALB2): c.757_758delCT (p.Leu253Ilefs) deletion Pathogenic rs180177092 GRCh38 Chromosome 16, 23635788: 23635789
24 PALB2 NM_024675.3(PALB2): c.757_758delCT (p.Leu253Ilefs) deletion Pathogenic rs180177092 GRCh37 Chromosome 16, 23647109: 23647110
25 PALB2 NM_024675.3(PALB2): c.1240C> T (p.Arg414Ter) single nucleotide variant Pathogenic rs180177100 GRCh38 Chromosome 16, 23635306: 23635306
26 PALB2 NM_024675.3(PALB2): c.1240C> T (p.Arg414Ter) single nucleotide variant Pathogenic rs180177100 GRCh37 Chromosome 16, 23646627: 23646627
27 PALB2 NM_024675.3(PALB2): c.3549C> A (p.Tyr1183Ter) single nucleotide variant Pathogenic rs118203998 GRCh38 Chromosome 16, 23603471: 23603471
28 PALB2 NM_024675.3(PALB2): c.3549C> A (p.Tyr1183Ter) single nucleotide variant Pathogenic rs118203998 GRCh37 Chromosome 16, 23614792: 23614792

Expression for Pancreatic Cancer 3

Search GEO for disease gene expression data for Pancreatic Cancer 3.

Pathways for Pancreatic Cancer 3

GO Terms for Pancreatic Cancer 3

Sources for Pancreatic Cancer 3

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