MCID: PNC103
MIFTS: 19

Pancreatic Cancer 4

Categories: Genetic diseases, Endocrine diseases, Cancer diseases, Rare diseases, Gastrointestinal diseases

Aliases & Classifications for Pancreatic Cancer 4

MalaCards integrated aliases for Pancreatic Cancer 4:

Name: Pancreatic Cancer 4 57 75 29 6
Pancreatic Cancer, Susceptibility to, 4 57 13
Pnca4 57 75
Cancer, Pancreatic, Susceptibility to, Type 4 40

Classifications:



External Ids:

OMIM 57 614320
MeSH 44 D010190

Summaries for Pancreatic Cancer 4

UniProtKB/Swiss-Prot : 75 Pancreatic cancer 4: A malignant neoplasm of the pancreas. Tumors can arise from both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue.

MalaCards based summary : Pancreatic Cancer 4, also known as pancreatic cancer, susceptibility to, 4, is related to pancreatic cancer and pancreatitis. An important gene associated with Pancreatic Cancer 4 is BRCA1 (BRCA1, DNA Repair Associated). Affiliated tissues include pancreas.

Description from OMIM: 614320

Related Diseases for Pancreatic Cancer 4

Diseases in the Pancreatic Cancer family:

Pancreatic Cancer 1 Pancreatic Cancer 2
Pancreatic Cancer 3 Pancreatic Cancer 4

Diseases related to Pancreatic Cancer 4 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 pancreatic cancer 9.8
2 pancreatitis 9.8
3 pancreas adenocarcinoma 9.7
4 adenocarcinoma 9.7
5 breast-ovarian cancer, familial 1 9.2 BRCA1 NBR2
6 adamantinoma of long bones 9.0 BRCA1 NBR2

Graphical network of the top 20 diseases related to Pancreatic Cancer 4:



Diseases related to Pancreatic Cancer 4

Symptoms & Phenotypes for Pancreatic Cancer 4

Clinical features from OMIM:

614320

Drugs & Therapeutics for Pancreatic Cancer 4

Search Clinical Trials , NIH Clinical Center for Pancreatic Cancer 4

Genetic Tests for Pancreatic Cancer 4

Genetic tests related to Pancreatic Cancer 4:

# Genetic test Affiliating Genes
1 Pancreatic Cancer 4 29 BRCA1

Anatomical Context for Pancreatic Cancer 4

MalaCards organs/tissues related to Pancreatic Cancer 4:

41
Pancreas

Publications for Pancreatic Cancer 4

Articles related to Pancreatic Cancer 4:

# Title Authors Year
1
Resection of metachronous pancreatic cancer 4 years after pancreaticoduodenectomy for stage III pancreatic adenocarcinoma. ( 26419361 )
2015
2
Usefulness of diffusion-weighted imaging (DWI) for the detection of pancreatic cancer: 4 case reports. ( 18507125 )
2008

Variations for Pancreatic Cancer 4

ClinVar genetic disease variations for Pancreatic Cancer 4:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 BRCA1 NM_007294.3(BRCA1): c.68_69delAG (p.Glu23Valfs) deletion Pathogenic rs80357783 GRCh37 Chromosome 17, 41276047: 41276048
2 BRCA1 NM_007294.3(BRCA1): c.68_69delAG (p.Glu23Valfs) deletion Pathogenic rs80357783 GRCh38 Chromosome 17, 43124030: 43124031
3 BRCA1 NM_007294.3(BRCA1): c.4327C> T (p.Arg1443Ter) single nucleotide variant Pathogenic rs41293455 GRCh37 Chromosome 17, 41234451: 41234451
4 BRCA1 NM_007294.3(BRCA1): c.4327C> T (p.Arg1443Ter) single nucleotide variant Pathogenic rs41293455 GRCh38 Chromosome 17, 43082434: 43082434
5 BRCA1 NM_007294.3(BRCA1): c.1259A> G (p.Asp420Gly) single nucleotide variant Uncertain significance rs730881442 GRCh38 Chromosome 17, 43094272: 43094272
6 BRCA1 NM_007294.3(BRCA1): c.1259A> G (p.Asp420Gly) single nucleotide variant Uncertain significance rs730881442 GRCh37 Chromosome 17, 41246289: 41246289

Expression for Pancreatic Cancer 4

Search GEO for disease gene expression data for Pancreatic Cancer 4.

Pathways for Pancreatic Cancer 4

GO Terms for Pancreatic Cancer 4

Sources for Pancreatic Cancer 4

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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