MCID: PNC016
MIFTS: 42

Pancreatic Cholera

Categories: Endocrine diseases, Gastrointestinal diseases

Aliases & Classifications for Pancreatic Cholera

MalaCards integrated aliases for Pancreatic Cholera:

Name: Pancreatic Cholera 12 15 73
Excessive Vasoactive Intestinal Peptide Secretion 12
Pancreatic Wdha Syndrome 12
Verner-Morrison Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6977
MeSH 44 D003969
NCIt 50 C3488
UMLS 73 C0086768

Summaries for Pancreatic Cholera

MalaCards based summary : Pancreatic Cholera, also known as excessive vasoactive intestinal peptide secretion, is related to wdha syndrome and vipoma. An important gene associated with Pancreatic Cholera is VIP (Vasoactive Intestinal Peptide), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Oxaliplatin and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and bone, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Wikipedia : 76 A VIPoma (also known as Verner–Morrison syndrome, after the physicians who first described it) is a rare... more...

Related Diseases for Pancreatic Cholera

Diseases related to Pancreatic Cholera via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 wdha syndrome 33.2 CALCA SST VIP
2 vipoma 32.4 GAST SCT SST VIP
3 pancreatitis 31.2 CCK SCT SST
4 secretory diarrhea 30.7 SST VIP
5 diarrhea 30.3 CCK GAST SST
6 multiple endocrine neoplasia, type i 28.3 GAST GHRH MEN1 SCT SST VIP
7 leprosy 2 10.8 CALCA VIP
8 hormone producing pituitary cancer 10.8 MEN1 SST
9 angiodysplasia 10.8 SCT SST
10 carcinoid tumors, intestinal 10.7 MEN1 SST
11 vasomotor rhinitis 10.7 CALCA VIP
12 cryptosporidiosis 10.7 SST VIP
13 prolactin producing pituitary tumor 10.7 CALCA SST
14 cluster headache 10.7 CALCA VIP
15 binswanger's disease 10.7 SST VIP
16 urticaria pigmentosa 10.7 CALCA VIP
17 functioning pituitary adenoma 10.7 MEN1 SST
18 biliary dyskinesia 10.7 CCK SCT
19 duodenal disease 10.6 CCK SCT
20 duodenum cancer 10.6 MEN1 SST
21 multiple endocrine neoplasia, type iib 10.6 CALCA MEN1
22 diffuse pulmonary fibrosis 10.6 CALCA VIP
23 hypophosphatasia, adult 10.6 CALCA SPTA1
24 ectopic cushing syndrome 10.6 MEN1 SST
25 gastrointestinal neuroendocrine benign tumor 10.6 GAST SST
26 hyperpituitarism 10.6 GHRH SST
27 pancreatic steatorrhea 10.6 CCK SCT
28 gastric neuroendocrine neoplasm 10.5 GAST SST
29 pancreatic gastrinoma 10.5 MEN1 SCT SST
30 pylorospasm 10.5 GAST SST
31 somatostatinoma 10.5 CALCA SST VIP
32 postgastrectomy syndrome 10.5 GIP SST VIP
33 cholera 10.5
34 pernicious anemia 10.4 GAST SST
35 metaphyseal chondrodysplasia, jansen type 10.4 CALCA SCT
36 steatorrhea 10.4 CCK SCT SST
37 thyroid cancer, nonmedullary, 2 10.4 CALCA MEN1 SST
38 diphyllobothriasis 10.4 GAST SCT
39 glycogen storage disease iii 10.4 CALCA GCG
40 functional gastric disease 10.4 CCK HRH2 SST
41 dyspepsia 10.4 CCK HRH2 SST
42 acute pancreatitis 10.4 CCK SCT SST
43 peliosis hepatis 10.3 GHRH MEN1
44 nasal cavity adenocarcinoma 10.3 CCK GAST
45 exocrine pancreatic insufficiency 10.3 CCK SCT
46 endocrine organ benign neoplasm 10.3 GHRH MEN1 SST
47 pituitary gland disease 10.3 GHRH MEN1 SST
48 acromegaly 10.3 GHRH MEN1 SST
49 hyperinsulinemic hypoglycemia, familial, 2 10.3 GAST SCT SST
50 alcoholic pancreatitis 10.3 CCK SCT

Graphical network of the top 20 diseases related to Pancreatic Cholera:



Diseases related to Pancreatic Cholera

Symptoms & Phenotypes for Pancreatic Cholera

MGI Mouse Phenotypes related to Pancreatic Cholera:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.43 SST GAST GIP HRH2 MEN1 SPTA1
2 homeostasis/metabolism MP:0005376 9.28 CCK GAST GHRH GIP HRH2 MEN1

Drugs & Therapeutics for Pancreatic Cholera

Drugs for Pancreatic Cholera (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 74)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxaliplatin Approved, Investigational Phase 2, Phase 3,Phase 1 61825-94-3 5310940 9887054 43805 6857599
2
Fluorouracil Approved Phase 2, Phase 3 51-21-8 3385
3
Bevacizumab Approved, Investigational Phase 2, Phase 3 216974-75-3
4
Levoleucovorin Approved, Investigational Phase 2, Phase 3,Phase 1 68538-85-2
5
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
6
leucovorin Approved, Nutraceutical Phase 2, Phase 3,Phase 3,Phase 1 58-05-9 143 6006
7
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
8 Pancreatic Polypeptide Investigational Phase 2, Phase 3,Phase 3,Phase 1 59763-91-6
9 Angiogenesis Inhibitors Phase 2, Phase 3,Phase 1
10 Angiogenesis Modulating Agents Phase 2, Phase 3,Phase 1
11 Immunosuppressive Agents Phase 2, Phase 3
12 Liver Extracts Phase 3,Phase 2,Phase 1
13 Antimetabolites Phase 2, Phase 3,Phase 1
14 Antimetabolites, Antineoplastic Phase 2, Phase 3,Phase 1
15 Analgesics Phase 3
16 Central Nervous System Depressants Phase 3
17 Adjuvants, Anesthesia Phase 3
18 Narcotics Phase 3
19 Analgesics, Opioid Phase 3
20 Anesthetics Phase 3
21 Anesthetics, General Phase 3
22 Anesthetics, Intravenous Phase 3
23 Peripheral Nervous System Agents Phase 3
24 Folate Nutraceutical Phase 2, Phase 3
25 Vitamin B9 Nutraceutical Phase 2, Phase 3
26 Cola Nutraceutical Phase 3,Phase 2,Phase 1
27
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
28
Irinotecan Approved, Investigational Phase 2 97682-44-5, 100286-90-6 60838
29
Gefitinib Approved, Investigational Phase 2 184475-35-2 123631
30
Melphalan Approved Phase 2 148-82-3 4053 460612
31
Octreotide Approved, Investigational Phase 2,Phase 1 83150-76-9 383414 6400441
32
Pancrelipase Approved, Investigational Phase 2 53608-75-6
33
Somatostatin Approved, Investigational Phase 2,Phase 1 38916-34-6, 51110-01-1 53481605
34
Nicotinamide Approved, Investigational, Nutraceutical Phase 2 98-92-0 936
35
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 11103-57-4, 68-26-8 445354
36
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
37 pancreatin Phase 2
38 Alkylating Agents Phase 2
39 topoisomerase I inhibitors Phase 2
40 Retinol palmitate Phase 2
41 Micronutrients Phase 2
42 Gastrointestinal Agents Phase 2,Phase 1
43 Nicotinic Acids Phase 2
44 Topoisomerase Inhibitors Phase 2
45 Trace Elements Phase 2
46 Hormones Phase 2,Phase 1
47 Anti-Bacterial Agents Phase 2
48 Vitamin B Complex Phase 2
49 Vitamins Phase 2
50 Antidotes Phase 2,Phase 1

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy and Bevacizumab in Treating Patients With Advanced Neuroendocrine Tumors Unknown status NCT00227617 Phase 2, Phase 3 5-fluorouracil;leucovorin;oxaliplatin
2 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
3 Sorafenib Tosylate in Treating Patients With Progressive Metastatic Neuroendocrine Tumors Completed NCT00131911 Phase 2 sorafenib tosylate
4 Gefitinib in Treating Patients With Progressive Metastatic Neuroendocrine Tumors Completed NCT00075439 Phase 2 gefitinib
5 Combination Chemotherapy as First-Line Therapy in Treating Patients With Locally Advanced or Metastatic Neuroendocrine Tumors of the Duodenum or Pancreas That Cannot Be Removed By Surgery Completed NCT00416767 Phase 2 fluorouracil;irinotecan hydrochloride;leucovorin calcium
6 AMG 706 and Octreotide in Treating Patients With Low-Grade Neuroendocrine Tumors Completed NCT00427349 Phase 2 AMG 706;octreotide
7 Hepatic Arterial Infusion of Melphalan With Hepatic Perfusion in Treating Patients With Unresectable Liver Cancer Completed NCT00096083 Phase 2 isolated perfusion;melphalan
8 Thalidomide in Treating Patients With Metastatic Neuroendocrine Tumors Completed NCT00027638 Phase 2 thalidomide
9 Internal Radiation Therapy in Treating Patients With Liver Metastases From Neuroendocrine Tumors Terminated NCT00466856 Phase 2 octreotide acetate
10 Vatalanib and Octreotide in Treating Patients With Progressive Neuroendocrine Tumors Withdrawn NCT00227773 Phase 2 octreotide acetate;vatalanib
11 Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu Completed NCT00004074 Phase 1
12 Trastuzumab Plus R115777 in Treating Patients With Advanced or Metastatic Cancer Completed NCT00005842 Phase 1 tipifarnib
13 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
14 Oxaliplatin With Or Without Floxuridine and Leucovorin in Treating Patients With Metastatic Cancer of the Peritoneum Completed NCT00005860 Phase 1 floxuridine;leucovorin calcium;oxaliplatin
15 Indium In 111 Pentetreotide in Treating Patients With Refractory Cancer Terminated NCT00002947 Phase 1
16 Disease-Specific Questionnaire in Assessing Quality of Life in Patients With Gastrointestinal-Related Neuroendocrine Tumors Unknown status NCT00454376

Search NIH Clinical Center for Pancreatic Cholera

Genetic Tests for Pancreatic Cholera

Anatomical Context for Pancreatic Cholera

MalaCards organs/tissues related to Pancreatic Cholera:

41
Pancreas, Liver, Bone, Small Intestine

Publications for Pancreatic Cholera

Articles related to Pancreatic Cholera:

(show all 29)
# Title Authors Year
1
Surgical treatment of pancreatic cholera: a case report. ( 8769928 )
1996
2
Increased tear secretion in pancreatic cholera: a newly recognized symptom in an experiment of nature. ( 2845780 )
1988
3
Pancreatic cholera syndrome due to a vasoactive intestinal polypeptide-producing tumor: further insights into the pathophysiology. ( 2828145 )
1988
4
Treatment of pancreatic cholera. ( 2827972 )
1988
5
Multiple endocrine neoplasia, type 1, with pancreatic cholera. ( 2886044 )
1987
6
Secretin, cholecystokinin, and vasoactive intestinal polypeptide in pancreatic cholera. ( 3019205 )
1986
7
Effect of a long-acting somatostatin analogue (SMS 201-995) in a patient with pancreatic cholera. ( 2856888 )
1985
8
Successful treatment of therapy-resistant pancreatic cholera with human leucocyte interferon. ( 2857998 )
1985
9
Pancreatic cholera syndrome: effect of a synthetic somatostatin analog on intestinal water and ion transport. ( 2862821 )
1985
10
Pancreatic cholera. ( 6322070 )
1984
11
VIP and the pancreatic cholera syndrome. ( 6325912 )
1984
12
Pancreatic cholera: is the diarrhea due to VIP? ( 6316137 )
1983
13
Streptozotocin treatment in pancreatic cholera (Verner-Morrison) syndrome. ( 6292031 )
1982
14
Effect of somatostatin on diarrhea and on small intestinal water and electrolyte transport in a patient with pancreatic cholera. ( 6122550 )
1982
15
Beneficial effect of oral lithium carbonate in the treatment of pancreatic cholera syndrome. ( 6246427 )
1980
16
Lithium carbonate in pancreatic cholera. ( 7421906 )
1980
17
Trifluoperazine reversal of secretory diarrhea in pancreatic cholera. ( 6250437 )
1980
18
The pancreatic cholera syndrome. ( 6244130 )
1980
19
Vasoactive intestinal peptide, the major mediator of the WDHA (pancreatic cholera) syndrome: value of measurement in diagnosis and treatment. ( 208414 )
1978
20
Indomethacin-responsive pancreatic cholera. ( 197410 )
1977
21
Intractable diarrhea. Intestinal perfusion studies and plasma VIP concentrations in patients with pancreatic cholera syndrome and surreptitious ingestion of laxatives and diuretics. ( 857657 )
1977
22
Pancreatic cholera. ( 173092 )
1975
23
Pancreatic cholera. Sudies on tumoral secretions and pathophysiology of diarrhea. ( 1097288 )
1975
24
Editorial: Streptozotocin for pancreatic cholera.'. ( 49526 )
1975
25
Islet cell carcinoma, pancreatic cholera, and vasoactive intestinal peptide. ( 173221 )
1975
26
Letter: Pancreatic cholera and vip. ( 1160944 )
1975
27
Pancreatic cholera (W.D.H.A. syndrome). Histochemical and ultrastructural studies. ( 170729 )
1975
28
Pancreatic cholera due to production of gastric inhibitory polypeptide. ( 4116232 )
1972
29
Watery diarrhea, hypokalemia and achlorhydria associated with pancreatic cholera. Case report. ( 4344758 )
1972

Variations for Pancreatic Cholera

Expression for Pancreatic Cholera

Search GEO for disease gene expression data for Pancreatic Cholera.

Pathways for Pancreatic Cholera

Pathways related to Pancreatic Cholera according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.66 CALCA CCK GAST GCG GHRH GIP
2
Show member pathways
13.18 CALCA CCK GCG GHRH GIP HRH2
3
Show member pathways
12.12 CALCA GCG GHRH GIP SCT
4
Show member pathways
11.8 GAST HRH2 SST
5 11.33 CALCA GCG GHRH GIP HRH2 SCT
6 10.1 CCK GAST SCT VIP
7 10.07 GAST HRH2

GO Terms for Pancreatic Cholera

Cellular components related to Pancreatic Cholera according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 CALCA CCK GAST GCG GHRH GIP
2 neuronal cell body GO:0043025 9.56 CALCA CCK GIP SST
3 extracellular region GO:0005576 9.36 CALCA CCK GAST GCG GHRH GIP
4 terminal bouton GO:0043195 9.33 CALCA CCK GHRH

Biological processes related to Pancreatic Cholera according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.71 CALCA GHRH PPY SST
2 G-protein coupled receptor signaling pathway GO:0007186 9.7 CALCA CCK GAST GCG GHRH GIP
3 positive regulation of protein binding GO:0032092 9.5 GCG MEN1 SPTA1
4 response to amino acid GO:0043200 9.49 GIP SST
5 response to starvation GO:0042594 9.48 GCG GIP
6 response to food GO:0032094 9.46 GAST GHRH
7 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.46 CALCA GCG GHRH VIP
8 positive regulation of cAMP-mediated signaling GO:0043950 9.43 GIP SCT
9 feeding behavior GO:0007631 9.43 CALCA GCG PPY
10 response to acidic pH GO:0010447 9.37 GIP SST
11 regulation of signaling receptor activity GO:0010469 9.32 CALCA CCK GAST GCG GHRH GIP

Molecular functions related to Pancreatic Cholera according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.28 CALCA CCK GAST GCG GIP PPY
2 neuropeptide hormone activity GO:0005184 9.13 CCK PPY VIP

Sources for Pancreatic Cholera

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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