MCID: PNC016
MIFTS: 32

Pancreatic Cholera

Categories: Endocrine diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Pancreatic Cholera

MalaCards integrated aliases for Pancreatic Cholera:

Name: Pancreatic Cholera 12 20 15 70
Verner-Morrison Syndrome 12 20
Wdha Syndrome 20 54
Watery Diarrhea, Hypokalemia, and Achlorhydria Syndrome 20
Excessive Vasoactive Intestinal Peptide Secretion 12
Pancreatic Wdha Syndrome 12
Watery Diarrhea Syndrome 20
Vipoma Syndrome 20

Classifications:



External Ids:

Disease Ontology 12 DOID:6977
MeSH 44 D003969
NCIt 50 C3488
SNOMED-CT 67 70091000
UMLS 70 C0086768

Summaries for Pancreatic Cholera

MalaCards based summary : Pancreatic Cholera, also known as verner-morrison syndrome, is related to secretory diarrhea and vipoma. An important gene associated with Pancreatic Cholera is VIP (Vasoactive Intestinal Peptide), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. Affiliated tissues include pancreas, pancreatic islet and colon.

Wikipedia : 73 A VIPoma or vipoma (/vɪˈpoʊmə/) is a rare endocrine tumor that overproduces vasoactive intestinal... more...

Related Diseases for Pancreatic Cholera

Diseases related to Pancreatic Cholera via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 186)
# Related Disease Score Top Affiliating Genes
1 secretory diarrhea 30.4 VIP SST
2 vipoma 30.3 VIP SST SCT PPY MEN1 GHRH
3 diarrhea 30.2 SST SCT GAST CALCA
4 ganglioneuroma 30.2 VIP SST CHGA
5 small cell carcinoma 29.8 GAST CHGA CALCA
6 hyperprolactinemia 29.8 VIP SST GHRH
7 pheochromocytoma 29.7 VIP SST MEN1 CHGA CALCA
8 parathyroid adenoma 29.6 MEN1 CHGA CALCA
9 adenoma 29.4 SST MEN1 GHRH CHGA
10 glucagonoma 29.3 VIP SST SCT GAST CHGA
11 hyperparathyroidism 29.1 SCT MEN1 GAST CHGA CALCA
12 insulinoma 28.7 SST SCT MEN1 GCG GAST CHGA
13 multiple endocrine neoplasia 28.6 VIP SST SCT MEN1 GAST CHGA
14 zollinger-ellison syndrome 28.4 SST SCT MEN1 HRH2 GHRH GAST
15 islet cell tumor 28.1 VIP SST SCT PPY MEN1 GHRH
16 neuroendocrine tumor 28.0 VIP SST SCT MEN1 GHRH GCG
17 multiple endocrine neoplasia, type i 27.7 VIP SST SCT PPY MEN1 GHRH
18 cholera 10.7
19 pancreatic vasoactive intestinal peptide producing tumor 10.4
20 nephrosclerosis 10.3
21 bronchopneumonia 10.3
22 uremia 10.3
23 leprosy 2 10.3 VIP CALCA
24 jejunal somatostatinoma 10.3 SST PPY
25 cluster headache 10.3 VIP CALCA
26 neurogenic bowel 10.3 VIP GAST
27 vasomotor rhinitis 10.2 VIP CALCA
28 adrenal gland pheochromocytoma 10.2
29 gastric antral vascular ectasia 10.2 SST GAST
30 abnormality of glucagon secretion 10.2 SST GCG
31 biliary dyskinesia 10.2 SST SCT
32 insulinomatosis and diabetes mellitus 10.2
33 glucose intolerance 10.2
34 ganglioneuroblastoma 10.2
35 large cell carcinoma 10.2
36 nasal cavity adenocarcinoma 10.2 GAST CALCA
37 diamond-blackfan anemia 5 10.2 SST PPY
38 barre-lieou syndrome 10.2 GCG CALCA
39 angular cheilitis 10.2 SST GCG
40 hypokalemia 10.2
41 ampulla of vater benign neoplasm 10.2 SST CHGA
42 extracranial neuroblastoma 10.2 VIP CHGA
43 angiodysplasia 10.2 SST SCT
44 cervical neuroblastoma 10.2 VIP CHGA
45 duodenal benign neoplasm 10.2 SST CHGA
46 volvulus of midgut 10.2 SST GCG
47 gastric hemangioma 10.2 SST CHGA
48 cryptosporidiosis 10.2 VIP SST
49 multiple mucosal neuroma 10.2 MEN1 CALCA
50 auditory system benign neoplasm 10.2 PPY CHGA

Graphical network of the top 20 diseases related to Pancreatic Cholera:



Diseases related to Pancreatic Cholera

Symptoms & Phenotypes for Pancreatic Cholera

Drugs & Therapeutics for Pancreatic Cholera

Search Clinical Trials , NIH Clinical Center for Pancreatic Cholera

Genetic Tests for Pancreatic Cholera

Anatomical Context for Pancreatic Cholera

MalaCards organs/tissues related to Pancreatic Cholera:

40
Pancreas, Pancreatic Islet, Colon, Thyroid

Publications for Pancreatic Cholera

Articles related to Pancreatic Cholera:

(show top 50) (show all 145)
# Title Authors PMID Year
1
VIPoma with expression of both VIP and VPAC1 receptors in a patient with WDHA syndrome. 54 61
19184565 2009
2
[Intractable diarrhoea revealing a neuroblastoma hypersecreting the vasoactive intestinal peptide]. 54 61
15051093 2004
3
A calcitonin and vasoactive intestinal peptide-producing pancreatic endocrine tumor associated with the WDHA syndrome. 61 54
14716055 2003
4
Multiple-hormone gene expression in ganglioneuroblastoma with watery diarrhea, hypokalemia, and achlorhydria syndrome. 54 61
7682155 1993
5
Characterization of an alpha-amidating activity in a human pancreatic tumour secreting vasoactive intestinal peptide (VIP). 61 54
2171816 1990
6
Cholera and Pancreatic Cholera: Is VIP the Common Pathophysiologic Factor? 61
32630790 2020
7
[Use of a somatostatin analog to improve a patient's condition and the subsequent diagnosis of pancreatic VIPoma:a case report]. 61
31941861 2020
8
Successful Treatment of Hypokalemic Rhabdomyolysis Caused by a Pancreatic VIPoma: A Case Report. 61
31754090 2019
9
[A Case of WDHA Water Diarrhea Hypokalemia Achlorhydria Syndrome that Developed after Multimodal Therapy for Retroperitoneal Paraganglioma]. 61
31501391 2019
10
Octreotide reverses shock due to vasoactive intestinal peptide-secreting adrenal pheochromocytoma: A case report and review of literature. 61
30510956 2018
11
Verner-Morrison syndrome. Literature review. 61
28730220 2017
12
Biochemical Testing in Patients with Neuroendocrine Tumors. 61
26303702 2015
13
A rare case of watery diarrhea, hypokalemia and achlorhydria syndrome caused by pheochromocytoma. 61
25081061 2014
14
[Verner-Morrison syndrome: a case study]. 61
20558361 2010
15
Tumor with watery diarrhoea, hypokalaemia in a 3-year-old girl. 61
19101728 2009
16
Hypokalemic rhabdomyolysis due to watery diarrhea, hypokalemia, achlorhydria (WDHA) syndrome caused by vipoma. 61
19488018 2009
17
A Pancreatic Polypeptide-Producing Pancreatic Tumor Causing WDHA Syndrome. 61
21490894 2008
18
Watery diarrhea, hypokalemia and achlorhydria syndrome due to an adrenal pheochromocytoma. 61
17729424 2007
19
Hypokalemic rhabdomyolysis due to WDHA syndrome caused by VIP-producing composite pheochromocytoma: a case in neurofibromatosis type 1. 61
16027147 2005
20
Large cell carcinoma with calcitonin and vasoactive intestinal polypeptide-associated Verner-Morrison syndrome. 54
15667039 2005
21
[WDHA syndrome by composite pheochromocytoma and ganglioneuroma]. 61
12082751 2002
22
[Aged watery diarrhea, hypokalemia, achlorhydria (WDHA) syndrome]. 61
11519114 2001
23
Epidemiology, clinical features and diagnosis of gastroenteropancreatic endocrine tumours. 54
11762360 2001
24
Tumor markers in neuroendocrine tumors. 61
10940685 2000
25
Tumour markers in neuroendocrine tumours. 61
10604122 1999
26
Long-term survival after diagnosis of hepatic metastatic VIPoma: report of two cases with disparate courses and review of therapeutic options. 61
10389687 1999
27
Pancreatic endocrine tumors: recent advances. 61
10436815 1999
28
Location of a VIPoma by iodine-123-vasoactive intestinal peptide scintigraphy. 54
9744346 1998
29
Metastatic pancreatic VIPoma: deteriorating clinical course and successful treatment by liver transplantation. 61
9577908 1998
30
Surgical treatment of pancreatic cholera: a case report. 61
8769928 1996
31
[A case report of the VIP producing tumor with liver metastasis presenting WDHA syndrome]. 61
7563932 1995
32
WDHA (watery diarrhea, hypokalemia, achlorhydria) syndrome: clinical features, diagnosis, and treatment. 61
7817223 1995
33
[WDHA syndrome]. 61
7837593 1994
34
Tc-99m sestamibi imaging of a pancreatic VIPoma and parathyroid adenoma in a patient with multiple type I endocrine neoplasia. 54
7914844 1994
35
Clinical use of the long acting somatostatin analogue octreotide in pediatrics. 61
8033916 1994
36
[WDHA syndrome]. 61
7736165 1994
37
[Diagnosis of Verner-Morrison syndrome (VDHA) and its treatment with sandostatin an streptozocitin]. 61
8247522 1993
38
["Microscopic colitis" and collagenous colitis. Unusual explanation of diarrhea of unknown origin]. 61
8480290 1993
39
[Somatostatin in preoperative therapy and postoperative diagnosis of a patient with Verner Morrison syndrome]. 54
1282641 1992
40
Giant metastatic VIPoma in the liver. 61
1655553 1991
41
Effects of preprovasoactive intestinal polypeptide-derived peptides on ileal output. 54
2153088 1990
42
A case of the watery diarrhea-hypokalemia-achlorhydria syndrome: successful preoperative treatment of watery diarrhea with a somatostatin analogue. 61
2554028 1989
43
Neuroendocrine pancreatic tumors. Clinical findings in a prospective study of 84 patients. 61
2472825 1989
44
[Chronic diarrhea caused by VIP-secreting ganglioneuroblastoma in children. Apropos of a case with a review of the literature]. 61
2680332 1989
45
Increased tear secretion in pancreatic cholera: a newly recognized symptom in an experiment of nature. 61
2845780 1988
46
Successful treatment of a VIPoma by continuous subcutaneous infusion of somatostatin analogue (SMS 201-995). 61
2856504 1988
47
[Effect of vasoactive intestinal peptide on the motility of guinea-pig colon in vitro]. 61
3246807 1988
48
Pancreatic cholera syndrome due to a vasoactive intestinal polypeptide-producing tumor: further insights into the pathophysiology. 61
2828145 1988
49
Treatment of pancreatic cholera. 61
2827972 1988
50
The morphology and neuroendocrine profile of pancreatic epithelial VIPomas and extrapancreatic, VIP-producing, neurogenic tumors. 61
2839087 1988

Variations for Pancreatic Cholera

Expression for Pancreatic Cholera

Search GEO for disease gene expression data for Pancreatic Cholera.

Pathways for Pancreatic Cholera

Pathways related to Pancreatic Cholera according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 VIP SST SCT PPY MEN1 HRH2
2
Show member pathways
13.04 VIP SST SCT PPY HRH2 GHRH
3
Show member pathways
12.14 SST SCT HRH2 GAST
4
Show member pathways
12.07 SCT GHRH GCG CALCA
5 11.94 VIP SST GCG
6 11.26 VIP SCT HRH2 GHRH GCG CALCA
7 10.02 HRH2 GAST
8 9.98 VIP SCT GAST

GO Terms for Pancreatic Cholera

Cellular components related to Pancreatic Cholera according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 SST SCT PPY GHRH GCG GAST
2 extracellular region GO:0005576 9.28 VIP SST SCT PPY GHRH GCG

Biological processes related to Pancreatic Cholera according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.54 SST GHRH CALCA
2 feeding behavior GO:0007631 9.33 PPY GCG CALCA
3 response to food GO:0032094 9.32 GHRH GAST
4 G protein-coupled receptor signaling pathway GO:0007186 9.28 VIP SST SCT PPY HRH2 GHRH
5 positive regulation of blood vessel diameter GO:0097755 9.26 VIP CALCA
6 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.26 VIP GHRH GCG CALCA

Molecular functions related to Pancreatic Cholera according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.23 VIP SST SCT PPY GHRH GCG
2 peptide hormone receptor binding GO:0051428 9.16 VIP GHRH
3 neuropeptide hormone activity GO:0005184 9.13 VIP PPY GHRH

Sources for Pancreatic Cholera

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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