MCID: PNC016
MIFTS: 37

Pancreatic Cholera

Categories: Endocrine diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Pancreatic Cholera

MalaCards integrated aliases for Pancreatic Cholera:

Name: Pancreatic Cholera 12 52 15 71
Verner-Morrison Syndrome 12 52
Watery Diarrhea, Hypokalemia, and Achlorhydria Syndrome 52
Excessive Vasoactive Intestinal Peptide Secretion 12
Pancreatic Wdha Syndrome 12
Watery Diarrhea Syndrome 52
Vipoma Syndrome 52
Wdha Syndrome 52

Classifications:



External Ids:

Disease Ontology 12 DOID:6977
MeSH 43 D003969
NCIt 49 C3488
SNOMED-CT 67 39998009
UMLS 71 C0086768

Summaries for Pancreatic Cholera

MalaCards based summary : Pancreatic Cholera, also known as verner-morrison syndrome, is related to ganglioneuroma and secretory diarrhea. An important gene associated with Pancreatic Cholera is VIP (Vasoactive Intestinal Peptide), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Fentanyl and Levoleucovorin have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and pancreatic islet.

Wikipedia : 74 A VIPoma or vipoma (/vɪˈpoʊmə/) is a rare endocrine tumor that overproduces vasoactive intestinal... more...

Related Diseases for Pancreatic Cholera

Diseases related to Pancreatic Cholera via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 194)
# Related Disease Score Top Affiliating Genes
1 ganglioneuroma 30.4 VIP SST CHGA
2 secretory diarrhea 30.4 VIP SST
3 vipoma 30.3 VIP SST SPINK5 SCT MEN1 GHRH
4 multiple endocrine neoplasia 29.8 MEN1 CALCA
5 hyperprolactinemia 29.7 VIP SST GHRH
6 small cell carcinoma 29.5 GAST CHGA CALCA
7 glucagonoma 29.4 VIP SST SCT GAST CHGA
8 adenoma 29.4 SST MEN1 GHRH CHGA
9 pancreatic cancer 29.3 VIP SST SCT MEN1 GAST CHGA
10 pheochromocytoma 29.3 VIP SST MEN1 CHGA CALCA
11 parathyroid adenoma 28.9 MEN1 GAST CHGA CALCA
12 diarrhea 28.9 SST SCT MEN1 HRH2 GAST CALCA
13 insulinoma 28.7 SST SCT MEN1 GCG GAST CHGA
14 hyperparathyroidism 28.5 SCT MEN1 GAST CHGA CALCA
15 zollinger-ellison syndrome 28.3 SST SCT PPY MEN1 HRH2 GHRH
16 neuroendocrine tumor 27.2 VIP SST SCT MEN1 GHRH GCG
17 islet cell tumor 26.9 VIP SST SPINK5 SCT PPY MEN1
18 multiple endocrine neoplasia, type i 26.7 VIP SST SPINK5 SCT PPY MEN1
19 pancreatic vasoactive intestinal peptide producing tumor 10.7
20 cholera 10.7
21 insulinomatosis and diabetes mellitus 10.4
22 glucose intolerance 10.4
23 ganglioneuroblastoma 10.4
24 large cell carcinoma 10.4
25 back pain 10.4
26 jejunal somatostatinoma 10.4 SST PPY
27 nephrosclerosis 10.4
28 bronchopneumonia 10.4
29 uremia 10.4
30 gastric antral vascular ectasia 10.4 SST GAST
31 adrenal gland pheochromocytoma 10.3
32 abnormality of glucagon secretion 10.3 SST GCG
33 biliary dyskinesia 10.3 SST SCT
34 petrositis 10.3 SST GCG
35 autoimmune atrophic gastritis 10.3 GAST CHGA
36 duodenal benign neoplasm 10.3 SST CHGA
37 bile reflux 10.3 SCT GAST
38 pancreas, annular 10.3 SCT PPY
39 ampulla of vater neoplasm 10.3 SST CHGA
40 angiodysplasia 10.3 SST SCT
41 mixed ductal-endocrine carcinoma 10.3 GAST CHGA
42 angular cheilitis 10.3 SST GCG
43 cervical neuroblastoma 10.3 VIP CHGA
44 goblet cell carcinoid 10.3 GAST CHGA
45 pituitary apoplexy 10.2 SST MEN1
46 gastric hemangioma 10.2 SST CHGA
47 auditory system benign neoplasm 10.2 PPY CHGA
48 extracranial neuroblastoma 10.2 VIP CHGA
49 rectum neuroendocrine neoplasm 10.2 VIP SST GAST
50 anal neuroendocrine tumor 10.2 SST SPINK5

Graphical network of the top 20 diseases related to Pancreatic Cholera:



Diseases related to Pancreatic Cholera

Symptoms & Phenotypes for Pancreatic Cholera

Drugs & Therapeutics for Pancreatic Cholera

Drugs for Pancreatic Cholera (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
2
Levoleucovorin Approved, Investigational Phase 2, Phase 3 68538-85-2
3
Fluorouracil Approved Phase 2, Phase 3 51-21-8 3385
4
leucovorin Approved Phase 2, Phase 3 58-05-9 6006 143
5
Oxaliplatin Approved, Investigational Phase 2, Phase 3 61825-94-3 43805 6857599 5310940 9887054
6
Bevacizumab Approved, Investigational Phase 2, Phase 3 216974-75-3
7
Folic acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
8 Pancreatic Polypeptide Investigational Phase 2, Phase 3 59763-91-6
9 Liver Extracts Phase 3
10 Cola Phase 3
11 Anesthetics Phase 3
12 Narcotics Phase 3
13 Analgesics Phase 3
14 Analgesics, Opioid Phase 3
15 Anesthetics, General Phase 3
16 Anesthetics, Intravenous Phase 3
17 Immunologic Factors Phase 2, Phase 3
18 Angiogenesis Inhibitors Phase 2, Phase 3
19 Immunosuppressive Agents Phase 2, Phase 3
20 Micronutrients Phase 2, Phase 3
21 Vitamins Phase 2, Phase 3
22 Antidotes Phase 2, Phase 3
23 Vitamin B Complex Phase 2, Phase 3
24 Folate Phase 2, Phase 3
25 Nutrients Phase 2, Phase 3
26 Trace Elements Phase 2, Phase 3
27 Vitamin B9 Phase 2, Phase 3
28 Antimetabolites Phase 2, Phase 3
29 Protective Agents Phase 2, Phase 3
30 Antineoplastic Agents, Immunological Phase 2, Phase 3
31
Irinotecan Approved, Investigational Phase 2 97682-44-5, 100286-90-6 60838
32
Pancrelipase Approved, Investigational Phase 2 53608-75-6
33
Melphalan Approved Phase 2 148-82-3 460612 4053
34
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
35
Imetelstat Investigational Phase 2 868169-64-6
36 Anti-Bacterial Agents Phase 2
37 Anti-Infective Agents Phase 2
38 topoisomerase I inhibitors Phase 2
39 Calcium, Dietary Phase 2
40 pancreatin Phase 2
41 Retinol palmitate Phase 2
42 retinol Phase 2
43
Motesanib diphosphate Phase 2 850649-62-6 11450633
44 Alkylating Agents Phase 2
45
Calcium Nutraceutical Phase 2 7440-70-2 271
46
Floxuridine Approved Phase 1 50-91-9 5790
47
Parathyroid hormone Approved, Investigational Phase 1 9002-64-6
48
Trastuzumab Approved, Investigational Phase 1 180288-69-1 9903
49
Phenylalanine Approved, Investigational, Nutraceutical Phase 1 63-91-2 6140
50
tipifarnib Investigational Phase 1 192185-72-1 159324

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
2 A Pilot Study of FOLFOX in Combination With Bevacizumab in Patients With Advanced Neuroendocrine Tumors Terminated NCT00227617 Phase 2, Phase 3 5-fluorouracil;leucovorin;oxaliplatin
3 Phase II Trial Of Thalidomide In Patients With Low Grade Neuroendocrine Tumors (Carcinoid and Islet Cell Cancers) Completed NCT00027638 Phase 2 thalidomide
4 Study of First-Line Therapy Comprising Leucovorin Calcium, Fluorouracil, and Irinotecan (FOLFIRI) in Patients With Progressive Locally Advanced or Metastatic Duodenal-Pancreatic Endocrine Tumors Completed NCT00416767 Phase 2 fluorouracil;irinotecan hydrochloride;leucovorin calcium
5 A Phase II Clinical and Biologic Study of AMG 706 and Octreotide in Patients With Low-Grade Neuroendocrine Tumors Completed NCT00427349 Phase 2 AMG 706;octreotide
6 A Phase II Study Of Hepatic Arterial Infusion Of Melphalan With Venous Filtration Via Peripheral Hepatic Perfusion (PHP) For Unresectable Primary And Metastatic Cancers Of The Liver Completed NCT00096083 Phase 2 isolated perfusion;melphalan
7 Clinical Trial of Sir-Spheres® in Patients With Symptomatic or Progressive Hepatic Metastases From Neuroendocrine Tumors Terminated NCT00466856 Phase 2 octreotide acetate
8 Phase II Study of Vatalanib and Octreotide in Patients With Progressive Low-Grade Neuroendocrine Tumors Withdrawn NCT00227773 Phase 2 octreotide acetate;vatalanib
9 A Phase I Study of Intraperitoneal Oxaliplatin Alone and in Combination With Intraperitoneal Floxuridine and Leucovorin in Patients With Advanced Metastatic Cancer Confined to the Peritoneal Cavity Completed NCT00005860 Phase 1 floxuridine;leucovorin calcium;oxaliplatin
10 A Phase I, Open-Label, Maximum Tolerated Single-Cycle and Four-Cycle Dose-Finding Study to Evaluation the Safety and Tolerability of 90Y-SMT 487 Administered by Intravenous Infusion to Subjects With Refractory Somatostatin-Receptor Positive Tumors Completed NCT00006368 Phase 1
11 A Phase I, Pharmacokinetic, and Biologic Correlative Study of R115777 (NSC 702818) and Herceptin in Patients With Advanced Cancer Completed NCT00005842 Phase 1 tipifarnib
12 A Phase I Study of [111In-DTPA-D-Phe]-Octreotide in Patients With Refractory Malignancies Expressing Somatostatin Receptors Terminated NCT00002947 Phase 1
13 Epidemiology of Chronic Diarrhea Among Children Admitted to Gastroenterology Unit at Assuit University Children Hospital Unknown status NCT03261297
14 Clinical and Psychometric Validation of a Disease-Specific Questionnaire Module in Assessing the Quality of Life of Patients With G.I.-Related Neuroendocrine Tumours Unknown status NCT00454376

Search NIH Clinical Center for Pancreatic Cholera

Genetic Tests for Pancreatic Cholera

Anatomical Context for Pancreatic Cholera

MalaCards organs/tissues related to Pancreatic Cholera:

40
Pancreas, Liver, Pancreatic Islet, Small Intestine, Colon, Adipocyte

Publications for Pancreatic Cholera

Articles related to Pancreatic Cholera:

(show top 50) (show all 136)
# Title Authors PMID Year
1
[VIPoma : a rare etiology of diarrhea with hypokalemia]. 61
29384277 2018
2
Verner-Morrison syndrome. Literature review. 61
28730220 2017
3
Sunitinib achieved fast and sustained control of VIPoma symptoms. 61
25305306 2015
4
[Neuroendocrine tumours of the GI tract--data from the German NET Registry]. 61
23042103 2014
5
Ischemic stroke as a presenting feature of VIPoma due to MEN 1 syndrome. 61
24251163 2013
6
[Verner-Morrison syndrome: a case study]. 61
20558361 2010
7
VIPoma syndrome: challenges in management. 61
20730389 2010
8
[Verner-Morrison syndrome revealing a ganglioneuroblastoma in an adult]. 61
18403149 2008
9
[Rare pancreatic endocrine tumors]. 61
18724549 2008
10
Large cell carcinoma with calcitonin and vasoactive intestinal polypeptide-associated Verner-Morrison syndrome. 61
15667039 2005
11
Epidemiology, clinical features and diagnosis of gastroenteropancreatic endocrine tumours. 61
11762360 2001
12
Dynamic gadolinium-enhanced MR imaging of pancreatic VIPoma in a patient with Verner-Morrison syndrome. 61
11702127 2001
13
Long-term survival after diagnosis of hepatic metastatic VIPoma: report of two cases with disparate courses and review of therapeutic options. 61
10389687 1999
14
Pancreatic endocrine tumors: recent advances. 61
10436815 1999
15
Location of a VIPoma by iodine-123-vasoactive intestinal peptide scintigraphy. 61
9744346 1998
16
Surgical treatment of pancreatic cholera: a case report. 61
8769928 1996
17
[Vasoactive polypeptide-producing pancreatic carcinoma]. 61
7566933 1995
18
Tc-99m sestamibi imaging of a pancreatic VIPoma and parathyroid adenoma in a patient with multiple type I endocrine neoplasia. 61
7914844 1994
19
Clinical use of the long acting somatostatin analogue octreotide in pediatrics. 61
8033916 1994
20
Management of gastroenteropancreatic endocrine tumors: the place of somatostatin analogues. 61
7698532 1994
21
[Diagnosis of Verner-Morrison syndrome (VDHA) and its treatment with sandostatin an streptozocitin]. 61
8247522 1993
22
["Microscopic colitis" and collagenous colitis. Unusual explanation of diarrhea of unknown origin]. 61
8480290 1993
23
[Somatostatin in preoperative therapy and postoperative diagnosis of a patient with Verner Morrison syndrome]. 61
1282641 1992
24
Four year treatment with a long acting somatostatin analogue in a patient with Verner-Morrison syndrome. 61
1663530 1991
25
Therapeutic strategies in the management of endocrine GEP tumours. 61
1702388 1990
26
Effects of preprovasoactive intestinal polypeptide-derived peptides on ileal output. 61
2153088 1990
27
Effects of prepro-vasoactive intestinal polypeptide-derived peptides on net fluid flux in small intestine of anesthetized rats. 61
2910755 1989
28
MR, CT, and ultrasound findings of metastatic vipoma in pancreas. 61
2562961 1989
29
Increased tear secretion in pancreatic cholera: a newly recognized symptom in an experiment of nature. 61
2845780 1988
30
Pancreatic cholera syndrome due to a vasoactive intestinal polypeptide-producing tumor: further insights into the pathophysiology. 61
2828145 1988
31
Treatment of pancreatic cholera. 61
2827972 1988
32
Effect of vasoactive intestinal polypeptide (VIP) on glucose and lipid metabolism of isolated rat adipocytes. 61
3420301 1988
33
Cardiovascular effects of vasoactive intestinal peptide in healthy subjects. 61
3687785 1987
34
Multiple endocrine neoplasia, type 1, with pancreatic cholera. 61
2886044 1987
35
[Medical topics: children with malaria with low blood sugar; Verner-Morrison syndrome]. 61
2826866 1987
36
Secretin, cholecystokinin, and vasoactive intestinal polypeptide in pancreatic cholera. 61
3019205 1986
37
Somatostatin analog-induced remission of necrolytic migratory erythema without changes in plasma glucagon concentration. 61
2882503 1986
38
Watery diarrhea syndrome caused by multihormonal malignant pancreatic islet cell tumor secreting somatostatin, vasoactive intestinal peptide, serotonin, and prostaglandin E--a clinicopathological, biochemical, immunohistochemical, and ultrastructural study. 61
2883647 1986
39
Pancreatic cholera syndrome: effect of a synthetic somatostatin analog on intestinal water and ion transport. 61
2862821 1985
40
Atypical Verner-Morrison syndrome. 61
2987152 1985
41
Successful treatment of therapy-resistant pancreatic cholera with human leucocyte interferon. 61
2857998 1985
42
Vasoactive intestinal polypeptide-, somatostatin-, and calcitonin-producing adrenal pheochromocytoma associated with the watery diarrhea (WDHH) syndrome. First case report with immunohistochemical findings. 61
2857107 1985
43
Effect of a long-acting somatostatin analogue (SMS 201-995) in a patient with pancreatic cholera. 61
2856888 1985
44
Secretory diarrhea with islet cell hyperplasia and increased immunohistochemical reactivity to serotonin. 61
6095478 1984
45
VIP and the pancreatic cholera syndrome. 61
6325912 1984
46
Effect of somatostatin infusion on VIP-induced transport changes in the human jejunum. 61
6147815 1984
47
Pancreatic cholera. 61
6322070 1984
48
Pancreatic cholera: is the diarrhea due to VIP? 61
6316137 1983
49
Production of secretory diarrhea by intravenous infusion of vasoactive intestinal polypeptide. 61
6316136 1983
50
Resolution of recurrent Verner-Morrison syndrome by resection of metastatic vipoma. 61
6297109 1983

Variations for Pancreatic Cholera

Expression for Pancreatic Cholera

Search GEO for disease gene expression data for Pancreatic Cholera.

Pathways for Pancreatic Cholera

Pathways related to Pancreatic Cholera according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.72 VIP SST SCT PPY MEN1 HRH2
2
Show member pathways
13.04 VIP SST SCT PPY HRH2 GHRH
3
Show member pathways
12.07 SCT GHRH GCG CALCA
4 11.94 VIP SST GCG
5
Show member pathways
11.8 SST HRH2 GAST
6 11.26 VIP SCT HRH2 GHRH GCG CALCA
7 9.98 VIP SCT GAST
8 9.96 HRH2 GAST

GO Terms for Pancreatic Cholera

Cellular components related to Pancreatic Cholera according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 SST SCT PPY GHRH GCG GAST
2 extracellular region GO:0005576 9.32 VIP SST SPINK5 SCT PPY GHRH

Biological processes related to Pancreatic Cholera according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 feeding behavior GO:0007631 9.33 PPY GCG CALCA
2 positive regulation of blood vessel diameter GO:0097755 9.32 VIP CALCA
3 G protein-coupled receptor signaling pathway GO:0007186 9.28 VIP SST SCT PPY HRH2 GHRH
4 response to food GO:0032094 9.26 GHRH GAST
5 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.26 VIP GHRH GCG CALCA

Molecular functions related to Pancreatic Cholera according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.23 VIP SST SCT PPY GHRH GCG
2 peptide hormone receptor binding GO:0051428 9.16 VIP GHRH
3 neuropeptide hormone activity GO:0005184 9.13 VIP PPY GHRH

Sources for Pancreatic Cholera

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....