MCID: PNC038
MIFTS: 34

Pancreatic Cystadenocarcinoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Pancreatic Cystadenocarcinoma

MalaCards integrated aliases for Pancreatic Cystadenocarcinoma:

Name: Pancreatic Cystadenocarcinoma 12 15
Cystadenocarcinoma of Pancreas 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4073
NCIt 50 C3874
UMLS 73 C0238337

Summaries for Pancreatic Cystadenocarcinoma

MalaCards based summary : Pancreatic Cystadenocarcinoma, also known as cystadenocarcinoma of pancreas, is related to pancreatic serous cystadenocarcinoma and cystadenocarcinoma, and has symptoms including abdominal pain, pruritus and icterus. An important gene associated with Pancreatic Cystadenocarcinoma is CPQ (Carboxypeptidase Q), and among its related pathways/superpathways are Selenium Micronutrient Network and Busulfan Pathway, Pharmacodynamics. The drugs Ethanol and Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and lymph node, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Pancreatic Cystadenocarcinoma

Diseases related to Pancreatic Cystadenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 pancreatic serous cystadenocarcinoma 11.2
2 cystadenocarcinoma 10.5
3 mucinous cystadenocarcinoma 10.2
4 chromosomal triplication 10.2 AFP KMT2A
5 secondary hypertrophic osteoarthropathy 10.2 CALCA KRAS
6 mature teratoma 10.1 AFP KRAS
7 sigmoid neoplasm 10.1 CEACAM5 KRAS
8 apocrine adenoma 10.1 CEACAM5 KRAS
9 aggressive digital papillary adenocarcinoma 10.1 CEACAM5 KRAS
10 atypical follicular adenoma 10.1 CALCA CEACAM5
11 mucinous cystadenofibroma 10.1 AFP CEACAM5
12 liver lymphoma 10.1 AFP CEACAM5
13 melanotic medulloblastoma 10.1 AFP CEACAM5
14 colonic benign neoplasm 10.1 CEACAM5 KRAS
15 hematocele of tunica vaginalis testis 10.1 AFP CEACAM5
16 biliary papillomatosis 10.1 CEACAM5 KRAS
17 bile duct cystadenocarcinoma 10.1 AFP CEACAM5
18 fetal adenoma 10.1 CALCA CEACAM5
19 liver sarcoma 10.1 AFP CEACAM5
20 rete testis adenocarcinoma 10.1 AFP CEACAM5
21 rete testis neoplasm 10.1 AFP CEACAM5
22 gastrointestinal system benign neoplasm 10.1 CEACAM5 KRAS
23 epidermolysis bullosa, junctional, herlitz type 10.1 AFP CEACAM5
24 ovary adenocarcinoma 10.1 CEACAM5 KRAS
25 mixed cell type cancer 10.0 AFP CEACAM5
26 intestinal benign neoplasm 10.0 CEACAM5 KRAS
27 ovarian cancer 1 10.0 CEACAM5 KRAS
28 tracheal cancer 10.0 AFP CEACAM5
29 testicular yolk sac tumor 10.0 AFP CEACAM5
30 malignant ovarian surface epithelial-stromal neoplasm 10.0 CEACAM5 KRAS
31 urachal adenocarcinoma 10.0 AFP CEACAM5 KRAS
32 thyroid carcinoma, familial medullary 10.0 CALCA CEACAM5 KRAS
33 bile duct adenocarcinoma 10.0 AFP CEACAM5 KRAS
34 gastrointestinal system cancer 10.0 AFP CEACAM5 KRAS
35 ovary epithelial cancer 10.0 CEACAM5 KRAS
36 extragonadal seminoma 10.0 AFP CALCA CEACAM5
37 crohn's disease 9.9
38 serous cystadenocarcinoma 9.9
39 mucinous ovarian cystadenoma 9.9
40 pancreatitis 9.9
41 cyclosporiasis 9.9 GGT1 GGT2
42 peutz-jeghers syndrome 9.9
43 zollinger-ellison syndrome 9.9
44 cystadenoma 9.9
45 pancreatic ductal carcinoma 9.9
46 pancreatic cystadenoma 9.9
47 ethmoid sinus cancer 9.9 GGT1 GGT2
48 ethmoid sinus adenocarcinoma 9.9 GGT1 GGT2
49 hepatic tuberculosis 9.9 GGT1 GGT2
50 cell type benign neoplasm 9.9 CEACAM5 KRAS

Graphical network of the top 20 diseases related to Pancreatic Cystadenocarcinoma:



Diseases related to Pancreatic Cystadenocarcinoma

Symptoms & Phenotypes for Pancreatic Cystadenocarcinoma

UMLS symptoms related to Pancreatic Cystadenocarcinoma:


abdominal pain, pruritus, icterus

GenomeRNAi Phenotypes related to Pancreatic Cystadenocarcinoma according to GeneCards Suite gene sharing:

26 (show all 27)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-1 9.96 TXN
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.96 AFP KRAS TXN
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.96 KRAS
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.96 KRAS
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-187 9.96 TXN
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-193 9.96 KRAS
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.96 TXN
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.96 KRAS
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 9.96 KRAS
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.96 KRAS
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.96 KRAS
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.96 AFP
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.96 KRAS
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.96 AFP
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.96 KRAS
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.96 AFP TXN
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.96 AFP
18 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.47 GGT2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.47 GGT1 GGT2 KMT2A
20 Increased shRNA abundance (Z-score > 2) GR00366-A-131 9.47 GGT2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.47 GGT1 GGT2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.47 KMT2A
23 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.47 GGT1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.47 KMT2A
25 Increased shRNA abundance (Z-score > 2) GR00366-A-24 9.47 GGT2
26 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.47 GGT1 GGT2
27 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.47 KMT2A

Drugs & Therapeutics for Pancreatic Cystadenocarcinoma

Drugs for Pancreatic Cystadenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 1 64-17-5 702
2
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
3 Anti-Infective Agents Phase 1
4 Antineoplastic Agents, Phytogenic Phase 1
5 Central Nervous System Depressants Phase 1
6 Albumin-Bound Paclitaxel Phase 1
7 Antibiotics, Antitubercular Phase 1
8 Anti-Infective Agents, Local Phase 1
9 Anti-Bacterial Agents Phase 1
10 Antimitotic Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Endoscopic Ultrasound (EUS) Guided Ethanol With Paclitaxel Ablation for Pancreatic Mucinous Cystic Neoplasm Terminated NCT01525706 Phase 1 Ethanol and Paclitaxel Injection

Search NIH Clinical Center for Pancreatic Cystadenocarcinoma

Genetic Tests for Pancreatic Cystadenocarcinoma

Anatomical Context for Pancreatic Cystadenocarcinoma

MalaCards organs/tissues related to Pancreatic Cystadenocarcinoma:

41
Pancreas, Liver, Lymph Node, Ovary, Colon, Thyroid, Testis

Publications for Pancreatic Cystadenocarcinoma

Articles related to Pancreatic Cystadenocarcinoma:

(show all 25)
# Title Authors Year
1
Pancreatic pseudocyst or mucinous cystadenocarcinoma of pancreas? A diagnostic dilemma. ( 28396777 )
2017
2
Serous cystadenocarcinoma of pancreas. ( 23763806 )
2013
3
Preoperative gemcitabine and oxaliplatin in a patient with ovarian metastasis from pancreatic cystadenocarcinoma. ( 22949893 )
2012
4
Metastatic lymph node impostor in pancreatic cystadenocarcinoma. ( 15767737 )
2005
5
Simultaneous mucinous cystadenoma of ovary and mucinous cystadenocarcinoma of pancreas. ( 11185714 )
2000
6
Pancreatitis associated with Crohn's disease: a premalignant state for cystadenocarcinoma of pancreas? ( 10445570 )
1999
7
Association between pancreatic cystadenocarcinoma, malignant liver cysts, and polycystic disease of the kidney. ( 9178704 )
1997
8
Pancreatic cystadenocarcinoma in Peutz-Jeghers syndrome. ( 9412957 )
1997
9
Needle aspiration cytology in the diagnosis of mucinous cystadenocarcinoma of pancreas. A study of five cases with an emphasis on utility and differential diagnosis. ( 7520925 )
1994
10
An alpha-fetoprotein producing pancreatic cystadenocarcinoma. ( 7522067 )
1994
11
Comparison between a newly established pancreatic cystadenocarcinoma cell-line, ocup-1 and cells derived from pancreatic ductal carcinoma. ( 21567058 )
1994
12
Immunohistochemical study of pancreatic cystadenocarcinoma. ( 1728123 )
1992
13
Pancreatic cystadenocarcinoma and pregnancy: a case report. ( 2368178 )
1990
14
Two cases of pancreatic cystadenocarcinoma with elevated CA 19-9 levels in the cystic fluid in comparison with two cases of pancreatic cystadenoma. ( 2693299 )
1989
15
Unique appearance of the duodenal papilla in pancreatic cystadenocarcinoma. ( 2539985 )
1989
16
Pancreatic cystadenocarcinoma associated with strongyloides. ( 6741978 )
1984
17
Zollinger-Ellison syndrome associated with pancreatic cystadenocarcinoma. ( 6493296 )
1984
18
Pancreatic cystadenocarcinoma--a diagnostic problem. ( 6850233 )
1983
19
Pancreatic cystadenocarcinoma: diagnostic problems. ( 7116085 )
1982
20
Cystadenocarcinoma of pancreas with hypokalaemia and hypoproteinaemia: case report. ( 7432823 )
1980
21
Pancreatic cystadenocarcinoma: CT body scan and gray scale ultrasound appearance. ( 98023 )
1978
22
A clinicopathologic study of 21 cases of pancreatic cystadenocarcinoma. ( 718294 )
1978
23
Cystadenocarcinoma of pancreas. ( 1063301 )
1976
24
Cystadenocarcinoma of pancreas with staged pancreatoduodenectomy. ( 4524587 )
1974
25
Cystadenocarcinoma of pancreas. Report of a case. ( 5545131 )
1971

Variations for Pancreatic Cystadenocarcinoma

Expression for Pancreatic Cystadenocarcinoma

Search GEO for disease gene expression data for Pancreatic Cystadenocarcinoma.

Pathways for Pancreatic Cystadenocarcinoma

GO Terms for Pancreatic Cystadenocarcinoma

Cellular components related to Pancreatic Cystadenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.1 CEACAM5 CPQ GGT1 GGT2 GLRX TXN

Biological processes related to Pancreatic Cystadenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular amino acid metabolic process GO:0006520 9.48 GGT1 GGT2
2 glutathione metabolic process GO:0006749 9.46 GGT1 GGT2
3 response to tumor necrosis factor GO:0034612 9.43 GGT1 GGT2
4 glutamate metabolic process GO:0006536 9.4 GGT1 GGT2
5 zymogen activation GO:0031638 9.37 GGT1 GGT2
6 glutathione catabolic process GO:0006751 9.32 GGT1 GGT2
7 leukotriene D4 biosynthetic process GO:1901750 9.26 GGT1 GGT2
8 cysteine biosynthetic process GO:0019344 9.16 GGT1 GGT2
9 regulation of immune system process GO:0002682 8.96 GGT1 GGT2
10 peptide modification GO:0031179 8.62 GGT1 GGT2

Molecular functions related to Pancreatic Cystadenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein disulfide oxidoreductase activity GO:0015035 9.16 GLRX TXN
2 glutathione hydrolase activity GO:0036374 8.96 GGT1 GGT2
3 peptidyltransferase activity GO:0000048 8.62 GGT1 GGT2

Sources for Pancreatic Cystadenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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