MCID: PNC038
MIFTS: 38

Pancreatic Cystadenocarcinoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Pancreatic Cystadenocarcinoma

MalaCards integrated aliases for Pancreatic Cystadenocarcinoma:

Name: Pancreatic Cystadenocarcinoma 12 15
Cystadenocarcinoma of Pancreas 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4073
NCIt 50 C3874
SNOMED-CT 68 235966007
UMLS 73 C0238337

Summaries for Pancreatic Cystadenocarcinoma

MalaCards based summary : Pancreatic Cystadenocarcinoma, also known as cystadenocarcinoma of pancreas, is related to pancreatic serous cystadenocarcinoma and sinonasal undifferentiated carcinoma, and has symptoms including abdominal pain, icterus and pruritus. An important gene associated with Pancreatic Cystadenocarcinoma is CPQ (Carboxypeptidase Q), and among its related pathways/superpathways are Folate Metabolism and NRF2 pathway. The drugs Ethanol and Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include pancreas, ovary and liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Pancreatic Cystadenocarcinoma

Diseases related to Pancreatic Cystadenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 pancreatic serous cystadenocarcinoma 11.1
2 sinonasal undifferentiated carcinoma 10.9 MKI67 SYP
3 esophageal neuroendocrine tumor 10.8 CHGA SYP
4 ureter small cell carcinoma 10.8 CHGA SYP
5 urinary bladder small cell neuroendocrine carcinoma 10.8 CHGA SYP
6 ovarian large-cell neuroendocrine carcinoma 10.8 CHGA SYP
7 auditory system cancer 10.8 CHGA SYP
8 adenoma of the pancreas 10.8 CHGA SYP
9 peritoneal serous adenocarcinoma 10.8 CHGA SYP
10 cellular ependymoma 10.8 CHGA SYP
11 gallbladder small cell carcinoma 10.8 CHGA SYP
12 primary hepatic neuroendocrine carcinoma 10.8 CHGA SYP
13 inflammatory mfh 10.8 SERPINA1 SERPINA3
14 small cell carcinoma of the bladder 10.8 CHGA SYP
15 gastrointestinal neuroendocrine tumor 10.8 CHGA SYP
16 adult teratoma 10.8 AFP CHGA
17 pulmonary large cell neuroendocrine carcinoma 10.8 CHGA SYP
18 chordoid meningioma 10.7 CHGA SYP
19 olfactory nerve neoplasm 10.7 CHGA SYP
20 cauda equina neoplasm 10.7 CHGA SYP
21 sclerosing hepatic carcinoma 10.7 AFP CHGA
22 conventional angiosarcoma 10.7 CHGA SYP
23 malignant sertoli cell tumor 10.7 AFP SYP
24 pancreatic somatostatinoma 10.7 CALCA SYP
25 polyembryoma 10.7 AFP SERPINA1
26 pancreatic acinar cell adenocarcinoma 10.7 AFP CHGA
27 secondary hypertrophic osteoarthropathy 10.7 CALCA KRAS
28 nodular ganglioneuroblastoma 10.7 CHGA SYP
29 scrotal carcinoma 10.6 AFP SERPINA3
30 pulmonary sclerosing hemangioma 10.6 CHGA SYP
31 sigmoid neoplasm 10.6 CEACAM5 KRAS
32 malignant fibroxanthoma 10.6 MKI67 SERPINA1 SERPINA3
33 pineocytoma 10.6 CHGA SYP
34 adenosquamous gallbladder carcinoma 10.6 CEACAM5 SERPINA3
35 malignant teratoma 10.6 AFP SYP
36 apocrine adenoma 10.6 CEACAM5 KRAS
37 gastric squamous cell carcinoma 10.6 CHGA SERPINA3 SYP
38 female urethral cancer 10.6 CEACAM5 CHGA
39 mature teratoma 10.6 AFP KRAS
40 endometrial small cell carcinoma 10.6 AFP SYP
41 respiratory system benign neoplasm 10.6 CHGA KRAS SYP
42 pulmonary blastoma 10.6 CHGA KRAS SYP
43 mediastinal cancer 10.5 AFP SYP
44 lung benign neoplasm 10.5 CHGA KRAS SYP
45 mucinous adenofibroma 10.5 CEACAM5 SYP
46 aggressive digital papillary adenocarcinoma 10.5 CEACAM5 KRAS
47 adenoid cystic carcinoma 10.5 KRAS MKI67 SERPINA3
48 subependymoma 10.5 CHGA SYP
49 granulosa cell tumor of the ovary 10.5 CHGA SERPINA1 SYP
50 urachal adenocarcinoma 10.5 AFP CEACAM5

Graphical network of the top 20 diseases related to Pancreatic Cystadenocarcinoma:



Diseases related to Pancreatic Cystadenocarcinoma

Symptoms & Phenotypes for Pancreatic Cystadenocarcinoma

UMLS symptoms related to Pancreatic Cystadenocarcinoma:


abdominal pain, icterus, pruritus

GenomeRNAi Phenotypes related to Pancreatic Cystadenocarcinoma according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-1 9.96 TXN
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.96 KRAS TXN AFP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.96 KRAS
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.96 KRAS
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-187 9.96 TXN
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-193 9.96 KRAS
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.96 TXN
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.96 KRAS
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 9.96 KRAS
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.96 KRAS
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.96 KRAS
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.96 AFP
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.96 KRAS
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.96 AFP
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.96 KRAS
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.96 TXN AFP
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.96 AFP
18 Reduced mammosphere formation GR00396-S 9.1 GGT1 KMT2A KRAS MUC5AC AFP CHGA

Drugs & Therapeutics for Pancreatic Cystadenocarcinoma

Drugs for Pancreatic Cystadenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 1 64-17-5 702
2
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
3 Albumin-Bound Paclitaxel Phase 1
4 Anti-Bacterial Agents Phase 1
5 Antibiotics, Antitubercular Phase 1
6 Anti-Infective Agents Phase 1
7 Anti-Infective Agents, Local Phase 1
8 Antimitotic Agents Phase 1
9 Antineoplastic Agents, Phytogenic Phase 1
10 Central Nervous System Depressants Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Endoscopic Ultrasound (EUS) Guided Ethanol With Paclitaxel Ablation for Pancreatic Mucinous Cystic Neoplasm Terminated NCT01525706 Phase 1 Ethanol and Paclitaxel Injection

Search NIH Clinical Center for Pancreatic Cystadenocarcinoma

Genetic Tests for Pancreatic Cystadenocarcinoma

Anatomical Context for Pancreatic Cystadenocarcinoma

MalaCards organs/tissues related to Pancreatic Cystadenocarcinoma:

41
Pancreas, Ovary, Liver, Kidney, Lymph Node

Publications for Pancreatic Cystadenocarcinoma

Articles related to Pancreatic Cystadenocarcinoma:

(show all 21)
# Title Authors Year
1
Pancreatic pseudocyst or mucinous cystadenocarcinoma of pancreas? A diagnostic dilemma. ( 28396777 )
2017
2
Serous cystadenocarcinoma of pancreas. ( 23763806 )
2013
3
Preoperative gemcitabine and oxaliplatin in a patient with ovarian metastasis from pancreatic cystadenocarcinoma. ( 22949893 )
2012
4
Metastatic lymph node impostor in pancreatic cystadenocarcinoma. ( 15767737 )
2005
5
Simultaneous mucinous cystadenoma of ovary and mucinous cystadenocarcinoma of pancreas. ( 11185714 )
2000
6
Pancreatitis associated with Crohn's disease: a premalignant state for cystadenocarcinoma of pancreas? ( 10445570 )
1999
7
Pancreatic cystadenocarcinoma in Peutz-Jeghers syndrome. ( 9412957 )
1997
8
Association between pancreatic cystadenocarcinoma, malignant liver cysts, and polycystic disease of the kidney. ( 9178704 )
1997
9
Needle aspiration cytology in the diagnosis of mucinous cystadenocarcinoma of pancreas. A study of five cases with an emphasis on utility and differential diagnosis. ( 7520925 )
1994
10
An alpha-fetoprotein producing pancreatic cystadenocarcinoma. ( 7522067 )
1994
11
Comparison between a newly established pancreatic cystadenocarcinoma cell-line, ocup-1 and cells derived from pancreatic ductal carcinoma. ( 21567058 )
1994
12
Immunohistochemical study of pancreatic cystadenocarcinoma. ( 1728123 )
1992
13
Pancreatic cystadenocarcinoma and pregnancy: a case report. ( 2368178 )
1990
14
Two cases of pancreatic cystadenocarcinoma with elevated CA 19-9 levels in the cystic fluid in comparison with two cases of pancreatic cystadenoma. ( 2693299 )
1989
15
Unique appearance of the duodenal papilla in pancreatic cystadenocarcinoma. ( 2539985 )
1989
16
Pancreatic cystadenocarcinoma associated with strongyloides. ( 6741978 )
1984
17
Zollinger-Ellison syndrome associated with pancreatic cystadenocarcinoma. ( 6493296 )
1984
18
Pancreatic cystadenocarcinoma--a diagnostic problem. ( 6850233 )
1983
19
Pancreatic cystadenocarcinoma: diagnostic problems. ( 7116085 )
1982
20
Pancreatic cystadenocarcinoma: CT body scan and gray scale ultrasound appearance. ( 98023 )
1978
21
A clinicopathologic study of 21 cases of pancreatic cystadenocarcinoma. ( 718294 )
1978

Variations for Pancreatic Cystadenocarcinoma

Expression for Pancreatic Cystadenocarcinoma

Search GEO for disease gene expression data for Pancreatic Cystadenocarcinoma.

Pathways for Pancreatic Cystadenocarcinoma

Pathways related to Pancreatic Cystadenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.59 GGT1 GGT2 SERPINA3 TXN
2 11.09 GGT1 GGT2 SERPINA1 TXN
3 10.64 GGT1 GGT2
4 10.52 GGT1 GGT2

GO Terms for Pancreatic Cystadenocarcinoma

Cellular components related to Pancreatic Cystadenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.81 CEACAM5 CPQ GGT1 GGT2 GLRX MUC5AC
2 extracellular space GO:0005615 9.56 AFP CALCA CHGA CPQ GGT1 MUC5AC
3 extracellular region GO:0005576 9.28 AFP CALCA CEACAM5 CHGA CPQ MUC5AC

Biological processes related to Pancreatic Cystadenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of long-term neuronal synaptic plasticity GO:0048169 9.37 KRAS SYP
2 zymogen activation GO:0031638 9.32 GGT1 GGT2
3 regulation of short-term neuronal synaptic plasticity GO:0048172 9.26 KMT2A SYP
4 positive regulation of cAMP metabolic process GO:0030816 9.16 CALCA CHGA
5 glutathione catabolic process GO:0006751 8.96 GGT1 GGT2
6 leukotriene D4 biosynthetic process GO:1901750 8.62 GGT1 GGT2

Molecular functions related to Pancreatic Cystadenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione hydrolase activity GO:0036374 8.62 GGT1 GGT2

Sources for Pancreatic Cystadenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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