MCID: PNC039
MIFTS: 39

Pancreatic Cystadenoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases

Aliases & Classifications for Pancreatic Cystadenoma

MalaCards integrated aliases for Pancreatic Cystadenoma:

Name: Pancreatic Cystadenoma 12 15
Cystadenoma of Pancreas 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3918
NCIt 50 C4374
UMLS 73 C0341486

Summaries for Pancreatic Cystadenoma

MalaCards based summary : Pancreatic Cystadenoma, also known as cystadenoma of pancreas, is related to cystadenoma and pancreatic somatostatinoma. An important gene associated with Pancreatic Cystadenoma is INS (Insulin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Glucose / Energy Metabolism. The drugs Ethanol and Central Nervous System Depressants have been mentioned in the context of this disorder. Affiliated tissues include pancreas, lung and liver, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Pancreatic Cystadenoma

Diseases related to Pancreatic Cystadenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 cystadenoma 10.6
2 pancreatic somatostatinoma 10.3 MEN1 SST
3 duodenal somatostatinoma 10.3 INS SST
4 postgastrectomy syndrome 10.3 INS SST
5 postural hypotension 10.3 INS SST
6 clear cell adenoma 10.3 CEACAM5 MEN1
7 hormone producing pituitary cancer 10.2 MEN1 SST
8 pancreatic endocrine carcinoma 10.2 INS SST
9 female urethral cancer 10.2 CEACAM5 CHGA
10 fibroepithelial basal cell carcinoma 10.2 CEACAM5 CHGA
11 hyperpituitarism 10.2 INS SST
12 atypical follicular adenoma 10.2 CEACAM5 CHGA
13 adenoma of the pancreas 10.2 CHGA SST
14 gastrointestinal neuroendocrine benign tumor 10.2 CHGA SST
15 gastrointestinal neuroendocrine tumor 10.2 CHGA SST
16 gastric neuroendocrine neoplasm 10.2 CHGA SST
17 maturity-onset diabetes of the young, type 10 10.2 FOXM1 INS
18 pancreatic serous cystadenoma 10.2 CEACAM5 CHGA
19 autoimmune polyendocrine syndrome, type ii 10.2 GAD2 INS
20 liver sarcoma 10.2 CEACAM5 CHGA
21 pituitary carcinoma 10.2 CHGA SST
22 gallbladder disease 10.2 CEACAM5 INS SST
23 pituitary gland disease 10.2 INS MEN1 SST
24 hyperinsulinemic hypoglycemia 10.2 INS MEN1 SST
25 glucagonoma 10.2 CHGA SST
26 acromegaly 10.2 INS MEN1 SST
27 duodenal disease 10.2 MEN1 SST
28 gastric small cell carcinoma 10.2 CEACAM5 CHGA
29 fanconi-bickel syndrome 10.2 INS SLC2A2
30 vipoma 10.2 CHGA SST
31 monocarboxylate transporter 1 deficiency 10.2 IAPP INS
32 pancreatoblastoma 10.2 CHGA SST
33 cystadenocarcinoma 10.2
34 type 1 diabetes mellitus 7 10.2 INS PTPRN
35 insulinomatosis and diabetes mellitus 10.1 CHGA INS SST
36 tanycytic ependymoma 10.1 CHGA MEN1
37 functioning pituitary adenoma 10.1 MEN1 SST
38 somatostatinoma 10.1 CHGA INS SST
39 mixed ductal-endocrine carcinoma 10.1 CEACAM5 CHGA SST
40 carcinoid tumors, intestinal 10.1 CHGA MEN1 SST
41 duodenal gastrinoma 10.1 CHGA MEN1 SST
42 maturity-onset diabetes of the young, type 2 10.1 INS PDX1
43 carcinoid syndrome 10.1 CHGA MEN1 SST
44 zollinger-ellison syndrome 10.1 CHGA MEN1 SST
45 serotonin syndrome 10.1 CHGA MEN1 SST
46 neuroendocrine tumor 10.1 CHGA MEN1 SST
47 small cell cancer of the lung 10.1 CEACAM5 CHGA SST
48 maturity-onset diabetes of the young, type 3 10.1 INS PDX1
49 binswanger's disease 10.1 CHGA SST
50 functional gastric disease 10.1 INS SST

Graphical network of the top 20 diseases related to Pancreatic Cystadenoma:



Diseases related to Pancreatic Cystadenoma

Symptoms & Phenotypes for Pancreatic Cystadenoma

GenomeRNAi Phenotypes related to Pancreatic Cystadenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00106-A-0 9.28 FOXM1 MEN1 RPS15 SLC2A2
2 Decreased viability GR00240-S-1 9.28 RPS15
3 Decreased viability GR00402-S-2 9.28 FOXM1 MEN1 RPS15 SLC2A2

MGI Mouse Phenotypes related to Pancreatic Cystadenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.11 CHGA FOXM1 GAD2 GLP1R INS MEN1
2 homeostasis/metabolism MP:0005376 10.07 CHGA FOXM1 GAD2 GLP1R IAPP INS
3 growth/size/body region MP:0005378 10.06 CHGA GAD2 GLP1R IAPP INS MEN1
4 digestive/alimentary MP:0005381 9.88 FOXM1 GAD2 INS MEN1 PDX1 SST
5 liver/biliary system MP:0005370 9.7 FOXM1 INS MEN1 PDX1 SLC2A2 SLC30A10
6 muscle MP:0005369 9.5 CHGA FOXM1 GAD2 INS MEN1 PDX1
7 no phenotypic analysis MP:0003012 9.1 CHGA GAD2 INS PDX1 SLC30A8 SST

Drugs & Therapeutics for Pancreatic Cystadenoma

Drugs for Pancreatic Cystadenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 2, Phase 3,Phase 1 64-17-5 702
2 Central Nervous System Depressants Phase 2, Phase 3,Phase 1
3 Anti-Infective Agents, Local Phase 2, Phase 3,Phase 1
4 Anti-Infective Agents Phase 2, Phase 3,Phase 1
5
Pancrelipase Approved, Investigational Phase 1 53608-75-6
6
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
7 pancreatin Phase 1
8 Hemostatics Phase 1
9 Antineoplastic Agents, Phytogenic Phase 1
10 Albumin-Bound Paclitaxel Phase 1
11 Antibiotics, Antitubercular Phase 1
12 Anti-Bacterial Agents Phase 1
13 Antimitotic Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 EUS-Guided Pancreatic Injection of Cyst (EPIC) Trial Completed NCT00233038 Phase 2, Phase 3
2 Laser Tissue Welding - Distal Pancreatectomy Sealing Study Recruiting NCT03147768 Phase 1
3 Endoscopic Ultrasound (EUS) Guided Ethanol With Paclitaxel Ablation for Pancreatic Mucinous Cystic Neoplasm Terminated NCT01525706 Phase 1 Ethanol and Paclitaxel Injection

Search NIH Clinical Center for Pancreatic Cystadenoma

Genetic Tests for Pancreatic Cystadenoma

Anatomical Context for Pancreatic Cystadenoma

MalaCards organs/tissues related to Pancreatic Cystadenoma:

41
Pancreas, Lung, Liver, Ovary, Pituitary, Thyroid, T Cells

Publications for Pancreatic Cystadenoma

Articles related to Pancreatic Cystadenoma:

(show all 40)
# Title Authors Year
1
Serous Pancreatic Cystadenoma with Compression of Wirsung's Duct. ( 29736662 )
2018
2
Mucinous cystadenoma of pancreas with honeycombing appearance: Radiological-Pathological correlation. ( 30319210 )
2018
3
Serous cystadenoma of pancreas: A clinicopathologic experience of 23 cases from a major tertiary care center. ( 30542522 )
2018
4
Serous cystadenoma of pancreas: imaging diagnosis. ( 26591957 )
2015
5
A rare complex association of pancreatic cystadenoma. ( 20182314 )
2010
6
Role of cystic fluid in diagnosis of the pancreatic cystadenoma and cystadenocarcinoma. ( 18251127 )
2007
7
Macrocystic pancreatic cystadenoma: The role of EUS and cyst fluid analysis in distinguishing mucinous and serous lesions. ( 15173795 )
2004
8
Surgical images: soft tissue. MA1llerian cyst of the upper abdomen: a lesion mimicking pancreatic cystadenoma. ( 15540691 )
2004
9
Stenosis of the common bile duct caused by synchronous pancreatic cystadenoma and cholangiocarcinoma. ( 12872115 )
2003
10
Macrocystic form of serous pancreatic cystadenoma. ( 12385440 )
2002
11
Hand-assisted laparoscopic distal pancreatectomy with minilaparotomy for distal pancreatic cystadenoma. ( 11330382 )
2001
12
Stricture of the main pancreatic duct due to focal pancreatitis coexistent with pancreatic cystadenoma. ( 10438172 )
1999
13
Hand-assisted laparoscopic distal pancreatectomy for pancreatic cystadenoma. ( 9649039 )
1998
14
Pancreatic tuberculosis: a rare condition mimicking pancreatic cystadenoma. ( 9788548 )
1998
15
Pancreatic cystadenoma and cystadenocarcinoma: diagnostic value of preoperative morphological investigations. ( 7727604 )
1995
16
Microcystic cystadenoma of pancreas. ( 7890956 )
1994
17
Macrocystic serous cystadenoma of pancreas--a case report. ( 8068223 )
1994
18
Pancreatic cystadenoma associated with von Recklinghausen's disease. ( 1748501 )
1991
19
Two cases of pancreatic cystadenocarcinoma with elevated CA 19-9 levels in the cystic fluid in comparison with two cases of pancreatic cystadenoma. ( 2693299 )
1989
20
Pancreatic cystadenoma. A clinicopathologic study. ( 2818178 )
1989
21
Pancreatic cystadenoma in an infant: ultrastructural study. ( 3227008 )
1988
22
Neonatal cytomegalovirus infection with pancreatic cystadenoma and nephrotic syndrome. ( 3035523 )
1986
23
Pancreatic cystadenoma. Angiographic and histologic findings illustrated by two cases. ( 6463235 )
1984
24
Pancreatic cystadenoma with obstructive jaundice. ( 6719173 )
1984
25
Pancreatic cystadenoma and cystadenocarcinoma. ( 6722483 )
1984
26
Pancreatic cystadenoma in Von Hippel-Lindau disease: an unusual cause of pancreatic and common bile duct obstruction. ( 7161467 )
1982
27
Pancreatic cystadenoma. ( 7288697 )
1981
28
Benign pancreatic cystadenoma. ( 6973071 )
1981
29
A pancreatic cystadenoma complicated by varices: case report. ( 7362948 )
1980
30
Pancreatic cystadenoma of the spleen. ( 453461 )
1979
31
Pancreatic cystadenoma. A clinicopathologic study of 45 cases. ( 637722 )
1978
32
Haemobilia from pancreatic cystadenoma. ( 1080997 )
1975
33
High abdominal aortic aneurysm, hepatic artery aneurysm, and cystadenoma of pancreas treated surgically in a young woman. ( 4579289 )
1973
34
Pancreatic cystadenoma and biliary tract disease. ( 5504218 )
1970
35
Pancreatic cystadenoma in childhood. Report of a case. ( 5803827 )
1969
36
Pancreatic cystadenoma: report of a case. ( 5638131 )
1968
37
Papillary cystadenoma of pancreas. ( 5224033 )
1966
38
PANCREATIC CYSTADENOMA WITH INTESTINAL HEMORRHAGE. ( 14068407 )
1963
39
Benign cystadenoma of pancreas; report of four treated cases, one by Whipple type of resection. ( 13156872 )
1954
40
Congestive splenomegaly due to pancreatic cystadenoma. ( 14935391 )
1952

Variations for Pancreatic Cystadenoma

Expression for Pancreatic Cystadenoma

Search GEO for disease gene expression data for Pancreatic Cystadenoma.

Pathways for Pancreatic Cystadenoma

Pathways related to Pancreatic Cystadenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.23 GCG GLP1R INS PDX1 SLC2A2
2 12.16 GAD2 GCG INS PDX1
3
Show member pathways
11.92 GCG GLP1R INS SLC2A2
4 11.82 GCG GLP1R IAPP
5 11.76 INS PDX1 SLC2A2
6
Show member pathways
11.7 INS PDX1 SLC2A2
7
Show member pathways
11.48 INS PDX1 SLC2A2
8
Show member pathways
10.92 IAPP INS PDX1 SLC2A2
9 10.78 INS PDX1 SLC2A2
10 10.61 INS SLC2A2

GO Terms for Pancreatic Cystadenoma

Cellular components related to Pancreatic Cystadenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule GO:0030141 9.13 CHGA PTPRN SLC30A8
2 transport vesicle membrane GO:0030658 8.8 CHGA PTPRN SLC30A8

Biological processes related to Pancreatic Cystadenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.78 GCG IAPP INS SST
2 glucose homeostasis GO:0042593 9.58 INS PDX1 SLC30A8
3 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.54 GCG GLP1R IAPP
4 cellular response to glucagon stimulus GO:0071377 9.46 GCG GLP1R
5 zinc ion transport GO:0006829 9.43 SLC30A10 SLC30A8
6 regulation of insulin secretion GO:0050796 9.33 GCG GLP1R SLC2A2
7 negative regulation of reactive oxygen species biosynthetic process GO:1903427 9.32 INS SLC30A10
8 negative regulation of blood vessel diameter GO:0097756 9.26 CHGA INS
9 type B pancreatic cell differentiation GO:0003309 8.96 MEN1 PDX1
10 insulin secretion GO:0030073 8.8 PDX1 PTPRN SLC30A8

Molecular functions related to Pancreatic Cystadenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cation transmembrane transporter activity GO:0008324 8.96 SLC30A10 SLC30A8
2 hormone activity GO:0005179 8.92 GCG IAPP INS SST

Sources for Pancreatic Cystadenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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