MCID: PNC027
MIFTS: 26

Pancreatic Gastrinoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases

Aliases & Classifications for Pancreatic Gastrinoma

MalaCards integrated aliases for Pancreatic Gastrinoma:

Name: Pancreatic Gastrinoma 12 15 73
Pancreatic G-Cell Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5580
NCIt 50 C9069 C95596
UMLS 73 C1368066

Summaries for Pancreatic Gastrinoma

MalaCards based summary : Pancreatic Gastrinoma, also known as pancreatic g-cell tumor, is related to gastrinoma and zollinger-ellison syndrome. An important gene associated with Pancreatic Gastrinoma is SCT (Secretin), and among its related pathways/superpathways is Glycogen Metabolism. The drugs Miconazole and Sirolimus have been mentioned in the context of this disorder. Affiliated tissues include endothelial, liver and lymph node.

Related Diseases for Pancreatic Gastrinoma

Graphical network of the top 20 diseases related to Pancreatic Gastrinoma:



Diseases related to Pancreatic Gastrinoma

Symptoms & Phenotypes for Pancreatic Gastrinoma

Drugs & Therapeutics for Pancreatic Gastrinoma

Drugs for Pancreatic Gastrinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
2
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 6436030 5284616
3
Everolimus Approved Phase 2 159351-69-6 6442177
4
Bevacizumab Approved, Investigational Phase 2 216974-75-3
5
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
6 Immunoglobulins Phase 2
7 Immunoglobulin G Phase 2
8 Anti-Infective Agents Phase 2
9 Immunologic Factors Phase 2
10 Antibodies Phase 2
11 Immunosuppressive Agents Phase 2
12 Antifungal Agents Phase 2
13 Angiogenesis Modulating Agents Phase 2
14 Anti-Bacterial Agents Phase 2
15 Antibodies, Monoclonal Phase 2
16 Antibiotics, Antitubercular Phase 2
17 Mitogens Phase 2
18 Angiogenesis Inhibitors Phase 2
19 Endothelial Growth Factors Phase 2
20 Liver Extracts Phase 2
21 Antineoplastic Agents, Hormonal Phase 2
22 Gastrointestinal Agents Phase 2
23
Pancrelipase Approved, Investigational Phase 1 53608-75-6
24 pancreatin Phase 1
25 Hemostatics Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Temsirolimus and Bevacizumab in Treating Patients With Advanced Endometrial, Ovarian, Liver, Carcinoid, or Islet Cell Cancer Completed NCT01010126 Phase 2 Temsirolimus
2 Everolimus and Octreotide Acetate With or Without Bevacizumab in Treating Patients With Locally Advanced or Metastatic Pancreatic Neuroendocrine Tumors That Cannot Be Removed by Surgery Active, not recruiting NCT01229943 Phase 2 Everolimus;Octreotide Acetate
3 Laser Tissue Welding - Distal Pancreatectomy Sealing Study Recruiting NCT03147768 Phase 1

Search NIH Clinical Center for Pancreatic Gastrinoma

Genetic Tests for Pancreatic Gastrinoma

Anatomical Context for Pancreatic Gastrinoma

MalaCards organs/tissues related to Pancreatic Gastrinoma:

41
Endothelial, Liver, Lymph Node, Small Intestine

Publications for Pancreatic Gastrinoma

Articles related to Pancreatic Gastrinoma:

# Title Authors Year
1
Management of pancreatic gastrinoma associated with Von Hippel-Lindau disease: a case report. ( 27055912 )
2016
2
An esophageal gastrointestinal stromal tumor in a patient with MEN1-related pancreatic gastrinoma: an unusual association and review of the literature. ( 25022420 )
2014
3
A rare surgical case of multiple liver resections for recurrent liver metastases from pancreatic gastrinoma: liver and vena cava resection. ( 19267257 )
2009
4
Putative auto-infarct of a pancreatic gastrinoma: a case report. ( 19089667 )
2007
5
Multiple endocrine neoplasia type II with Zollinger-Ellison syndrome caused by a solitary pancreatic gastrinoma. ( 2567786 )
1989
6
Favourable response to conservative surgery for extra-pancreatic gastrinoma with lymph node metastases. ( 3567510 )
1987

Variations for Pancreatic Gastrinoma

Expression for Pancreatic Gastrinoma

Search GEO for disease gene expression data for Pancreatic Gastrinoma.

Pathways for Pancreatic Gastrinoma

Pathways related to Pancreatic Gastrinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.18 PPP2R5B PYGM

GO Terms for Pancreatic Gastrinoma

Biological processes related to Pancreatic Gastrinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 brain development GO:0007420 8.62 MEN1 SCT

Molecular functions related to Pancreatic Gastrinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein N-terminus binding GO:0047485 8.62 MEN1 SCT

Sources for Pancreatic Gastrinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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