MCID: PNC027
MIFTS: 27

Pancreatic Gastrinoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases

Aliases & Classifications for Pancreatic Gastrinoma

MalaCards integrated aliases for Pancreatic Gastrinoma:

Name: Pancreatic Gastrinoma 12 15 73
Pancreatic G-Cell Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5580
NCIt 50 C9069 C95596
UMLS 73 C1368066

Summaries for Pancreatic Gastrinoma

MalaCards based summary : Pancreatic Gastrinoma, also known as pancreatic g-cell tumor, is related to pancreatitis and gastrinoma. An important gene associated with Pancreatic Gastrinoma is SCT (Secretin). The drugs Miconazole and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include liver, endothelial and lymph node.

Related Diseases for Pancreatic Gastrinoma

Diseases related to Pancreatic Gastrinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 pancreatitis 30.3 SCT SST
2 gastrinoma 29.9 MEN1 SCT SST
3 zollinger-ellison syndrome 29.2 MEN1 SCT SST
4 multiple endocrine neoplasia, type i 29.2 MEN1 SCT SST
5 glucagonoma 10.3 SCT SST
6 hyperinsulinemic hypoglycemia, familial, 2 10.3 SCT SST
7 angiodysplasia 10.3 SCT SST
8 duodenogastric reflux 10.3 SCT SST
9 vipoma 10.2 SCT SST
10 dumping syndrome 10.2 SCT SST
11 steatorrhea 10.2 SCT SST
12 pancreatic somatostatinoma 10.2 MEN1 SST
13 hormone producing pituitary cancer 10.2 MEN1 SST
14 pancreas disease 10.2 SCT SST
15 carcinoid tumors, intestinal 10.2 MEN1 SST
16 peptic ulcer disease 10.2 MEN1 SCT
17 functioning pituitary adenoma 10.2 MEN1 SST
18 carcinoid syndrome 10.1 MEN1 SST
19 duodenum cancer 10.1 MEN1 SST
20 ectopic cushing syndrome 10.1 MEN1 SST
21 islet cell tumor 10.1 MEN1 SST
22 endocrine organ benign neoplasm 10.1 MEN1 SST
23 duodenal ulcer 10.1 SCT SST
24 pituitary tumors 10.1 MEN1 SST
25 serotonin syndrome 10.1 MEN1 SST
26 organ system benign neoplasm 10.1 MEN1 SST
27 acute pancreatitis 10.1 SCT SST
28 pituitary gland disease 10.1 MEN1 SST
29 cell type benign neoplasm 10.0 MEN1 SST
30 gastrointestinal system disease 10.0 SCT SST
31 pituitary adenoma, prolactin-secreting 10.0 MEN1 SST
32 acromegaly 10.0 MEN1 SST
33 duodenitis 10.0
34 multiple endocrine neoplasia 10.0
35 thyroid carcinoma, familial medullary 9.9 MEN1 SST
36 neuroendocrine tumor 9.9 MEN1 SST
37 thyroid cancer, nonmedullary, 2 9.9 MEN1 SST
38 gastrointestinal stromal tumor 9.8
39 esophagitis 9.8
40 meningioma, familial 9.7 MEN1 SST
41 pancreatic cholera 9.7 MEN1 SCT SST
42 duodenal gastrinoma 9.7 MEN1 SCT SST
43 endocrine gland cancer 9.7 MEN1 SCT SST
44 insulinoma 9.7 MEN1 SCT SST
45 adenoma 9.6 MEN1 SST
46 pheochromocytoma 9.3 MEN1 SST
47 pancreatic cancer 9.2 MEN1 SCT SST

Graphical network of the top 20 diseases related to Pancreatic Gastrinoma:



Diseases related to Pancreatic Gastrinoma

Symptoms & Phenotypes for Pancreatic Gastrinoma

Drugs & Therapeutics for Pancreatic Gastrinoma

Drugs for Pancreatic Gastrinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
2
Everolimus Approved Phase 2 159351-69-6 6442177
3
Bevacizumab Approved, Investigational Phase 2 216974-75-3
4
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
5
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
6 Mitogens Phase 2
7 Angiogenesis Inhibitors Phase 2
8 Angiogenesis Modulating Agents Phase 2
9 Endothelial Growth Factors Phase 2
10 Anti-Bacterial Agents Phase 2
11 Antibiotics, Antitubercular Phase 2
12 Immunoglobulin G Phase 2
13 Antibodies Phase 2
14 Immunoglobulins Phase 2
15 Antibodies, Monoclonal Phase 2
16 Immunosuppressive Agents Phase 2
17 Anti-Infective Agents Phase 2
18 Antifungal Agents Phase 2
19 Liver Extracts Phase 2
20 Gastrointestinal Agents Phase 2
21 Antineoplastic Agents, Hormonal Phase 2
22
Pancrelipase Approved, Investigational Phase 1 53608-75-6
23 pancreatin Phase 1
24 Hemostatics Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Temsirolimus and Bevacizumab in Treating Patients With Advanced Endometrial, Ovarian, Liver, Carcinoid, or Islet Cell Cancer Completed NCT01010126 Phase 2 Temsirolimus
2 Everolimus and Octreotide Acetate With or Without Bevacizumab in Treating Patients With Locally Advanced or Metastatic Pancreatic Neuroendocrine Tumors That Cannot Be Removed by Surgery Active, not recruiting NCT01229943 Phase 2 Everolimus;Octreotide Acetate
3 Laser Tissue Welding - Distal Pancreatectomy Sealing Study Recruiting NCT03147768 Phase 1

Search NIH Clinical Center for Pancreatic Gastrinoma

Genetic Tests for Pancreatic Gastrinoma

Anatomical Context for Pancreatic Gastrinoma

MalaCards organs/tissues related to Pancreatic Gastrinoma:

41
Liver, Endothelial, Lymph Node

Publications for Pancreatic Gastrinoma

Articles related to Pancreatic Gastrinoma:

# Title Authors Year
1
Management of pancreatic gastrinoma associated with Von Hippel-Lindau disease: a case report. ( 27055912 )
2016
2
An esophageal gastrointestinal stromal tumor in a patient with MEN1-related pancreatic gastrinoma: an unusual association and review of the literature. ( 25022420 )
2014
3
Sonic hedgehog and pancreatic-duodenal homeobox 1 expression distinguish between duodenal and pancreatic gastrinomas. ( 19240184 )
2009
4
A rare surgical case of multiple liver resections for recurrent liver metastases from pancreatic gastrinoma: liver and vena cava resection. ( 19267257 )
2009
5
Putative auto-infarct of a pancreatic gastrinoma: a case report. ( 19089667 )
2007
6
Prospective study of surgical resection of duodenal and pancreatic gastrinomas in multiple endocrine neoplasia type 1. ( 7491542 )
1995
7
Multiple endocrine neoplasia type II with Zollinger-Ellison syndrome caused by a solitary pancreatic gastrinoma. ( 2567786 )
1989
8
Favourable response to conservative surgery for extra-pancreatic gastrinoma with lymph node metastases. ( 3567510 )
1987

Variations for Pancreatic Gastrinoma

Expression for Pancreatic Gastrinoma

Search GEO for disease gene expression data for Pancreatic Gastrinoma.

Pathways for Pancreatic Gastrinoma

GO Terms for Pancreatic Gastrinoma

Biological processes related to Pancreatic Gastrinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 8.8 PPP2R5B SCT SST

Molecular functions related to Pancreatic Gastrinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.96 SCT SST
2 protein N-terminus binding GO:0047485 8.62 MEN1 SCT

Sources for Pancreatic Gastrinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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