MCID: PNC027
MIFTS: 30

Pancreatic Gastrinoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases

Aliases & Classifications for Pancreatic Gastrinoma

MalaCards integrated aliases for Pancreatic Gastrinoma:

Name: Pancreatic Gastrinoma 12 15 17 70
Pancreatic G-Cell Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5580
NCIt 50 C9069
UMLS 70 C1368066

Summaries for Pancreatic Gastrinoma

MalaCards based summary : Pancreatic Gastrinoma, also known as pancreatic g-cell tumor, is related to gastrinoma and multiple endocrine neoplasia. An important gene associated with Pancreatic Gastrinoma is GAST (Gastrin), and among its related pathways/superpathways are Salivary secretion and G alpha (s) signalling events. Affiliated tissues include liver, pancreas and pituitary, and related phenotype is digestive/alimentary.

Related Diseases for Pancreatic Gastrinoma

Diseases related to Pancreatic Gastrinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 283)
# Related Disease Score Top Affiliating Genes
1 gastrinoma 30.4 SST SCT MEN1 GAST CHGA
2 multiple endocrine neoplasia 29.9 SST SCT MEN1 GAST CHGA
3 gastrointestinal stromal tumor 29.8 SYP SST MEN1 CHGA
4 pheochromocytoma 29.6 SYP SST MEN1 CHGA
5 zollinger-ellison syndrome 29.1 SST SCT MEN1 HRH2 GAST CHGA
6 islet cell tumor 28.7 SYP SST SCT PPY MEN1 GCG
7 multiple endocrine neoplasia, type i 28.5 SYP SST SCT PPY MEN1 GCG
8 neuroendocrine tumor 28.4 SYP SST SCT MEN1 GCG GAST
9 autoimmune atrophic gastritis 10.3 GAST CHGA
10 pituitary infarct 10.3 SST MEN1
11 goblet cell carcinoid 10.3 GAST CHGA
12 jejunal somatostatinoma 10.3 SST PPY
13 small intestine neuroendocrine neoplasm 10.3 SST MEN1
14 pancreatic somatostatinoma 10.3 SST PPY
15 hormone producing pituitary cancer 10.3 SST MEN1
16 ectopic cushing syndrome 10.3 SST CHGA
17 pituitary apoplexy 10.2 SST MEN1
18 hyperpituitarism 10.2 SST MEN1
19 pituitary adenoma 1, multiple types 10.2 SST MEN1
20 vagus nerve disease 10.2 ATP4A ATP12A
21 necrotizing gastritis 10.2 ATP4A ATP12A
22 scalp dermatosis 10.2 ATP4A ATP12A
23 hemangioma of intra-abdominal structure 10.2 ATP4A ATP12A
24 abnormality of glucagon secretion 10.2 SST GCG
25 acquired gastric outlet stenosis 10.2 ATP4A ATP12A
26 lingual goiter 10.2 ATP4A ATP12A
27 bacterial esophagitis 10.2 ATP4A ATP12A
28 benzylpenicillin allergy 10.2 ATP4A ATP12A
29 median arcuate ligament syndrome 10.2 ATP4A ATP12A
30 afferent loop syndrome 10.2 ATP4A ATP12A
31 cervix erosion 10.2 ATP4A ATP12A
32 angiodysplasia of intestine 10.2 ATP4A ATP12A
33 laryngeal tuberculosis 10.2 ATP4A ATP12A
34 fungal esophagitis 10.2 ATP4A ATP12A
35 dieulafoy lesion 10.2 ATP4A ATP12A
36 esophagus melanoma 10.2 ATP4A ATP12A
37 cefuroxime allergy 10.2 ATP4A ATP12A
38 emphysematous cholecystitis 10.2 ATP4A ATP12A
39 pneumatosis cystoides intestinalis 10.2 ATP4A ATP12A
40 viral laryngitis 10.2 ATP4A ATP12A
41 gastroduodenal crohn's disease 10.2 ATP4A ATP12A
42 polyposis, skin pigmentation, alopecia, and fingernail changes 10.2 ATP4A ATP12A
43 central nervous system origin vertigo 10.2 ATP4A ATP12A
44 rumination disorder 10.2 ATP4A ATP12A
45 internal hemorrhoid 10.2 ATP4A ATP12A
46 pituitary tumors 10.2 SST MEN1
47 hemorrhoid 10.2 ATP4A ATP12A
48 acute laryngitis 10.2 ATP4A ATP12A
49 chronic intestinal vascular insufficiency 10.2 ATP4A ATP12A
50 barbiturate abuse 10.2 ATP4A ATP12A

Graphical network of the top 20 diseases related to Pancreatic Gastrinoma:



Diseases related to Pancreatic Gastrinoma

Symptoms & Phenotypes for Pancreatic Gastrinoma

MGI Mouse Phenotypes related to Pancreatic Gastrinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.1 ATP12A ATP4A GAST HRH2 MEN1 SST

Drugs & Therapeutics for Pancreatic Gastrinoma

Search Clinical Trials , NIH Clinical Center for Pancreatic Gastrinoma

Genetic Tests for Pancreatic Gastrinoma

Anatomical Context for Pancreatic Gastrinoma

MalaCards organs/tissues related to Pancreatic Gastrinoma:

40
Liver, Pancreas, Pituitary, Lymph Node, Spleen

Publications for Pancreatic Gastrinoma

Articles related to Pancreatic Gastrinoma:

(show top 50) (show all 64)
# Title Authors PMID Year
1
Pancreatic Gastrinoma, Gastrointestinal Stromal Tumor (GIST), Pheochromocytoma, and Hürthle Cell Neoplasm in a Patient with Neurofibromatosis Type 1: A Case Report and Literature Review. 61
33452231 2021
2
A novel mutation of the MEN1 gene in a patient with multiple endocrine neoplasia type 1 and recurrent fibromyxoid sarcoma - a case report. 61
32993530 2020
3
[A case of difficult to diagnose duodenal gastrinoma]. 61
32779588 2020
4
Gastrinoma and Zollinger-Ellison syndrome in canids: a literature review and a case in a Mexican gray wolf. 61
29860931 2018
5
Gastrin Induces Nuclear Export and Proteasome Degradation of Menin in Enteric Glial Cells. 61
28859856 2017
6
Disease Control on Lanreotide Autogel® 120 mg in a Patient with Metastatic Gastrinoma: A Case Report. 61
29430219 2017
7
Management of pancreatic gastrinoma associated with Von Hippel-Lindau disease: a case report. 61
27055912 2017
8
Metastatic gastrinoma in the breast mimicking primary solid papillary carcinoma. 61
27342908 2016
9
Zollinger-Ellison syndrome: Revelation of the gastrinoma triangle. 61
27408649 2015
10
Gastrinoma and neurofibromatosis type 2: the first case report and review of the literature. 61
24961548 2014
11
An esophageal gastrointestinal stromal tumor in a patient with MEN1-related pancreatic gastrinoma: an unusual association and review of the literature. 61
25022420 2014
12
Case 200: Gastric enterochromaffinlike cell tumors in a patient with type 1 multiple endocrine neoplasia. 61
24261501 2013
13
Metastatic tumors to the urinary bladder: clinicopathologic study of 11 cases. 61
22134629 2012
14
Zollinger-Ellison syndrome associated with a history of alcohol abuse: coincidence or consequence? 61
22136832 2011
15
Surgical treatment of multiple spine metastases from gastrinoma. 61
23230405 2011
16
A de novo 0.57 Mb microdeletion in chromosome 11q13.1 in a patient with speech problems, autistic traits, dysmorphic features and multiple endocrine neoplasia type 1. 61
21600320 2011
17
An unusual clinical presentation of a dog with gastrinoma. 61
22131581 2011
18
Biochemically curative surgery for gastrinoma in multiple endocrine neoplasia type 1 patients. 61
21455335 2011
19
[Peripancreatic sporadic gastrinoma]. 61
20890828 2010
20
Recent standardization of treatment strategy for pancreatic neuroendocrine tumors. 61
20857521 2010
21
Percutaneous radiofrequency ablation approach through the spleen: initial case report for pancreatic tail gastrinoma. 61
20800027 2010
22
Long-term results of a selective surgical approach to management of Zollinger-Ellison syndrome in patients with MEN-1. 61
19725300 2009
23
A rare surgical case of multiple liver resections for recurrent liver metastases from pancreatic gastrinoma: liver and vena cava resection. 61
19267257 2009
24
Giant gastrinoma in a child: case report and review. 61
18679689 2008
25
[Observation of pancreatic gastrinoma]. 61
18982731 2008
26
Usefulness of F-18 FDG-PET in detection of multiple endocrine tumors with duodenal carcinoid. 61
17383156 2007
27
Putative auto-infarct of a pancreatic gastrinoma: a case report. 61
19089667 2007
28
Preoperative detection of gastrointestinal neuroendocrine tumors using endoscopic ultrasonography. 61
17198475 2006
29
Surgical treatment and prognosis of gastrinoma. 61
16253901 2005
30
A case of canine gastrinoma. 61
15353855 2004
31
Intensity-modulated stereotactic radiotherapy of paraspinal tumors: a preliminary report. 61
15046647 2004
32
Cushing's syndrome from ectopic production of corticotropin by a metastatic gastrinoma. 61
12917066 2003
33
Concurrent parathyroid adenomas and carcinoma in the setting of multiple endocrine neoplasia type 1: presentation as hypercalcemic crisis. 61
12173721 2002
34
A malignant gastrointestinal stromal tumour in a patient with multiple endocrine neoplasia type 1. 61
11246625 2001
35
Bilateral pituitary adenomas occurring with multiple endocrine neoplasia type one. 61
10871015 2000
36
Large goiter and multiple rib tumors. 61
10855684 2000
37
Mixed ductal-endocrine carcinoma of the pancreas presenting as gastrinoma with Zollinger-Ellison syndrome: an autopsy case with a 24-year survival period. 61
10628803 1999
38
A personal experience with pancreatic and duodenal neuroendocrine tumors. 61
10549736 1999
39
[The diagnosis and preoperative location of digestive endocrine tumors by endoscopic ultrasonography]. 61
10396102 1999
40
Expression of the growth hormone secretagogue receptor in pituitary adenomas and other neuroendocrine tumors. 61
9768675 1998
41
Localization, malignant potential, and surgical management of gastrinomas. 61
9606277 1998
42
Pancreatic-polypeptide cell hyperplasia associated with pancreatic or duodenal gastrinomas. 61
9023394 1997
43
Preoperative detection of duodenal gastrinomas and peripancreatic lymph nodes by somatostatin receptor scintigraphy. Groupe D'etude Du Syndrome De Zollinger-Ellison. 61
8831579 1996
44
[Extrahepatic gastrinoma. Report of a clinical case]. 61
8924490 1996
45
Uncommon case of gastrinoma in a child. 61
8817213 1996
46
[Hepatic metastases of pancreatic gastrinoma associated with sclerosing hepatocellular carcinoma]. 61
8642778 1996
47
Duodenal gastrinoma: the solution to the pancreatic paradox. 61
7806825 1994
48
A metastatic neuroendocrine anaplastic small cell tumor in a patient with multiple endocrine neoplasia type 1 syndrome. Assessment of disease status and response to doxorubicin, cyclophosphamide, etoposide chemotherapy through scintigraphic imaging with 111In-pentetreotide. 61
7922988 1994
49
Multiple endocrine neoplasm, type 1. Gastrinomas, pancreatic neoplasms, microcarcinoids, the Zollinger-Ellison syndrome, lymph nodes, and hepatic metastases. 61
8105768 1993
50
Interferon-alpha in the treatment of neuroendocrine tumours: effect on glucose tolerance and glucose-stimulated insulin secretion. 61
8102540 1993

Variations for Pancreatic Gastrinoma

Expression for Pancreatic Gastrinoma

Search GEO for disease gene expression data for Pancreatic Gastrinoma.

Pathways for Pancreatic Gastrinoma

Pathways related to Pancreatic Gastrinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.79 SST SCT HRH2 GAST ATP4A
2 11.6 SCT HRH2 GCG
3 10 SCT GAST
4 9.5 HRH2 GAST ATP4A

GO Terms for Pancreatic Gastrinoma

Cellular components related to Pancreatic Gastrinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 SST SCT PPY GCG GAST CHGA

Biological processes related to Pancreatic Gastrinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular sodium ion homeostasis GO:0006883 9.32 ATP4A ATP12A
2 sodium ion export across plasma membrane GO:0036376 9.26 ATP4A ATP12A
3 cellular potassium ion homeostasis GO:0030007 9.16 ATP4A ATP12A
4 G protein-coupled receptor signaling pathway GO:0007186 9.1 SST SCT PPY HRH2 GCG GAST
5 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.96 ATP4A ATP12A

Molecular functions related to Pancreatic Gastrinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.26 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 9.16 ATP4A ATP12A
3 hormone activity GO:0005179 9.02 SST SCT PPY GCG GAST
4 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP4A ATP12A

Sources for Pancreatic Gastrinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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