MCID: PNC043
MIFTS: 30

Pancreatic Intraductal Papillary-Mucinous Neoplasm

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Pancreatic Intraductal Papillary-Mucinous Neoplasm

MalaCards integrated aliases for Pancreatic Intraductal Papillary-Mucinous Neoplasm:

Name: Pancreatic Intraductal Papillary-Mucinous Neoplasm 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:7575
NCIt 51 C38342
UMLS 74 C1518869

Summaries for Pancreatic Intraductal Papillary-Mucinous Neoplasm

MalaCards based summary : Pancreatic Intraductal Papillary-Mucinous Neoplasm is related to acute pancreatitis and lynch syndrome, and has symptoms including abdominal pain and icterus. An important gene associated with Pancreatic Intraductal Papillary-Mucinous Neoplasm is MUC6 (Mucin 6, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are O-linked glycosylation and Diseases of glycosylation. The drugs Pancrelipase and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include brain.

Related Diseases for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Diseases related to Pancreatic Intraductal Papillary-Mucinous Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 acute pancreatitis 10.3
2 lynch syndrome 10.3
3 alcoholic pancreatitis 10.3
4 pancreatitis 10.3
5 cholangitis 10.3
6 recurrent acute pancreatitis 10.3
7 solid adenocarcinoma with mucin production 10.1 MUC1 MUC6
8 chronic ethmoiditis 10.1 MUC1 MUC6
9 microcystic adenoma 10.1 MUC1 MUC6
10 bile duct cystadenocarcinoma 10.1 MUC1 MUC6
11 appendix disease 10.1 GNAS MUC6
12 adenomyoma 10.1 MUC1 MUC6
13 mucinous tubular and spindle renal cell carcinoma 10.1 MUC1 MUC6
14 biliary papillomatosis 10.1 MUC1 MUC6
15 ethmoid sinusitis 10.1 MUC1 MUC6
16 duodenum cancer 10.1 MUC1 MUC6
17 pseudomyxoma peritonei 10.1 MUC1 MUC6
18 gastric tubular adenocarcinoma 10.1 MUC1 MUC6
19 mixed ductal-endocrine carcinoma 10.1 MUC1 MUC6
20 signet ring cell adenocarcinoma 10.1 MUC1 MUC6
21 ampulla of vater cancer 10.1 MUC1 MUC6
22 villous adenoma 10.1 GNAS MUC1
23 pancreatic ductal carcinoma 10.0 MUC1 MUC6
24 cystadenoma 10.0 MUC1 MUC6
25 colorectal cancer 1 10.0 MUC1 MUC6
26 osteofibrous dysplasia 10.0 GNAS MUC1
27 cholecystitis 10.0 MUC1 MUC6
28 sinonasal undifferentiated carcinoma 9.9 MKI67 MUC1
29 endometrial mucinous adenocarcinoma 9.9 MKI67 MUC1
30 polymorphous low-grade adenocarcinoma 9.9 MKI67 MUC1
31 endocrine gland cancer 9.8 GNAS MUC1
32 malignant fibroxanthoma 9.8 MKI67 MUC1
33 appendix cancer 9.8 GNAS MUC1 MUC6
34 meningioma, radiation-induced 9.8 MKI67 MUC1
35 cavernous hemangioma 9.8 MKI67 MUC1
36 ependymoma 9.8 MKI67 MUC1
37 ductal carcinoma in situ 9.7 MKI67 MUC1
38 mucoepidermoid carcinoma 9.7 MKI67 MUC1
39 large intestine cancer 9.7 GNAS MUC1 RNF43
40 barrett esophagus 9.7 MKI67 MUC6
41 adenoid cystic carcinoma 9.5 MKI67 MUC1
42 tumor of exocrine pancreas 9.5 GNAS MUC1 MUC6 RNF43
43 pancreas adenocarcinoma 9.5 GNAS MUC1 MUC6 RNF43
44 colorectal cancer 9.4 GNAS MUC1 MUC6 RNF43

Graphical network of the top 20 diseases related to Pancreatic Intraductal Papillary-Mucinous Neoplasm:



Diseases related to Pancreatic Intraductal Papillary-Mucinous Neoplasm

Symptoms & Phenotypes for Pancreatic Intraductal Papillary-Mucinous Neoplasm

UMLS symptoms related to Pancreatic Intraductal Papillary-Mucinous Neoplasm:


abdominal pain, icterus

Drugs & Therapeutics for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Drugs for Pancreatic Intraductal Papillary-Mucinous Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pancrelipase Approved, Investigational Phase 3,Not Applicable 53608-75-6
2
Fluorouracil Approved Phase 3 51-21-8 3385
3
Gemcitabine Approved Phase 3 95058-81-4 60750
4
Capecitabine Approved, Investigational Phase 3 154361-50-9 60953
5 Anti-Infective Agents Phase 3,Not Applicable
6 pancreatin Phase 3,Not Applicable
7 Protein Kinase Inhibitors Phase 3
8
Erlotinib Hydrochloride Phase 3 183319-69-9 176871
9 Antiviral Agents Phase 3
10 Antimetabolites Phase 3
11 Immunosuppressive Agents Phase 3
12 Antimetabolites, Antineoplastic Phase 3
13 Immunologic Factors Phase 3
14
Ethanol Approved Not Applicable 64-17-5 702
15
Paclitaxel Approved, Vet_approved Not Applicable 33069-62-4 36314
16 Antineoplastic Agents, Phytogenic Not Applicable
17 Albumin-Bound Paclitaxel Not Applicable
18 Antimitotic Agents Not Applicable
19 Central Nervous System Depressants Not Applicable
20 Anti-Infective Agents, Local Not Applicable
21 Hematinics Not Applicable
22 Parenteral Nutrition Solutions Not Applicable
23 Ferrosoferric Oxide Not Applicable
24 Pharmaceutical Solutions Not Applicable
25 Gastrointestinal Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Gemcitabine Hydrochloride With or Without Erlotinib Hydrochloride Followed by the Same Chemotherapy Regimen With or Without Radiation Therapy and Capecitabine or Fluorouracil in Treating Patients With Pancreatic Cancer That Has Been Removed by Surgery Active, not recruiting NCT01013649 Phase 3 Capecitabine;Chemotherapy;Erlotinib Hydrochloride;Fluorouracil;Gemcitabine Hydrochloride
2 Endoscopic Ultrasound (EUS)-Guided Ablation of Pancreatic Cysts Recruiting NCT01643460 Not Applicable
3 DCE MRI in Patients With Pancreatic Cancer Recruiting NCT02070705 Not Applicable Ferumoxytol
4 High Volume Washing of the Abdomen in Increasing Survival After Surgery in Patients With Pancreatic Cancer That Can Be Removed by Surgery Recruiting NCT02757859 Not Applicable
5 Diagnosis of PCL With EUS-FNA and Cross-sectional Imaging - A Report of Accuracy Active, not recruiting NCT03884179
6 Ultra-High Resolution Optical Coherence Tomography in Detecting Micrometer Sized Early Stage Pancreatic Cancer in Participants With Pancreatic Cancer Not yet recruiting NCT03711890 Not Applicable

Search NIH Clinical Center for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Genetic Tests for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Anatomical Context for Pancreatic Intraductal Papillary-Mucinous Neoplasm

MalaCards organs/tissues related to Pancreatic Intraductal Papillary-Mucinous Neoplasm:

42
Brain

Publications for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Articles related to Pancreatic Intraductal Papillary-Mucinous Neoplasm:

(show all 26)
# Title Authors Year
1
Management of pancreatic intraductal papillary mucinous neoplasm. ( 29753366 )
2018
2
Double cystic brain metastasis in a patient with stable pancreatic intraductal papillary mucinous neoplasm. ( 29557198 )
2018
3
Role of SpyGlass-DS<sup>tm</sup> in the preoperative assessment of pancreatic intraductal papillary mucinous neoplasm involving the main pancreatic duct. ( 29730245 )
2018
4
The role of pancreatic juice cytology in the diagnosis of pancreatic intraductal papillary mucinous neoplasm. ( 30168338 )
2018
5
Incisional Malignant Evolution of Pancreatic Intraductal Papillary Mucinous Neoplasm. ( 30454512 )
2018
6
An Appraisal of Current Guidelines for Managing Malignancy in Pancreatic Intraductal Papillary Mucinous Neoplasm. ( 30636939 )
2018
7
The oncocytic subtype is genetically distinct from other pancreatic intraductal papillary mucinous neoplasm subtypes. ( 27282351 )
2016
8
Fundic gland differentiation of oncocytic/pancreatobiliary subtypes of pancreatic intraductal papillary mucinous neoplasm. ( 26990132 )
2016
9
Characterization of intraductal papillary neoplasm of bile duct with respect to histopathologic similarities to pancreatic intraductal papillary mucinous neoplasm. ( 27067788 )
2016
10
Associating pancreaticostomy and biliary-irrigation for staged pancreaticoduodenectomy approach to pancreatic intraductal papillary mucinous neoplasm with recurrent cholangitis and severe jaundice: A case report. ( 27902614 )
2016
11
Criteria for Determining Malignancy in Pancreatic Intraductal Papillary Mucinous Neoplasm Based on Computed Tomography. ( 28030856 )
2016
12
Incidental Regression of a Suspected Pancreatic Intraductal Papillary Mucinous Neoplasm after Nontarget Embolization. ( 27287972 )
2016
13
Direct peroral pancreatoscopy with a pediatric gastroscope for preoperative evaluation of the pancreatic duct in a patient with pancreatic intraductal papillary mucinous neoplasm. ( 26671542 )
2015
14
Pancreatic intraductal papillary mucinous neoplasm--where is the challenge? ( 25531503 )
2015
15
Pancreatic intraductal papillary mucinous neoplasm in a patient with Lynch syndrome. ( 25759555 )
2015
16
A Case Report: Cavitary Infarction Caused by Pulmonary Tumor Thrombotic Microangiopathy in a Patient with Pancreatic Intraductal Papillary Mucinous Neoplasm. ( 26175596 )
2015
17
Pancreatic intraductal papillary mucinous neoplasm invading the duodenum: a case report and a review of the literature. ( 24622089 )
2014
18
Air in the main pancreatic duct associated with a pancreatic intraductal papillary mucinous neoplasm. ( 26182136 )
2013
19
Is it necessary to follow patients after resection of a benign pancreatic intraductal papillary mucinous neoplasm? ( 23395158 )
2013
20
Favorable response after gemcitabine-radiotherapy for invasive pancreatic intraductal papillary mucinous neoplasm: a case report. ( 24229021 )
2013
21
Management of pancreatic intraductal papillary mucinous neoplasm in an academic hospital (2005-2010): what follow-up for unoperated patients? ( 23160482 )
2013
22
Frequency of subtypes of biliary intraductal papillary mucinous neoplasm and their MUC1, MUC2, and DPC4 expression patterns differ from pancreatic intraductal papillary mucinous neoplasm. ( 22112419 )
2012
23
Endoscopic ultrasound (EUS) aspect of duodenal bulb invasion by multifocal malignant pancreatic intraductal papillary mucinous neoplasm (IPMN). ( 21837609 )
2011
24
Pancreatic intraductal papillary mucinous neoplasm with concomitant heterotopic pancreatic cystic neoplasia of the stomach: a case report and review of the literature. ( 20205774 )
2010
25
The utility of F-18 FDG PET/CT in the evaluation of pancreatic intraductal papillary mucinous neoplasm. ( 20838285 )
2010
26
Surgical decompression in the patients of pancreatic intraductal papillary mucinous neoplasm. ( 18265673 )
2007

Variations for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Expression for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Search GEO for disease gene expression data for Pancreatic Intraductal Papillary-Mucinous Neoplasm.

Pathways for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Pathways related to Pancreatic Intraductal Papillary-Mucinous Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.22 MUC1 MUC6
2
Show member pathways
10.79 MUC1 MUC6

GO Terms for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Cellular components related to Pancreatic Intraductal Papillary-Mucinous Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.62 MUC1 MUC6

Biological processes related to Pancreatic Intraductal Papillary-Mucinous Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 stimulatory C-type lectin receptor signaling pathway GO:0002223 8.96 MUC1 MUC6
2 O-glycan processing GO:0016266 8.62 MUC1 MUC6

Sources for Pancreatic Intraductal Papillary-Mucinous Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
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43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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