MCID: PNC043
MIFTS: 34

Pancreatic Intraductal Papillary-Mucinous Neoplasm

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Pancreatic Intraductal Papillary-Mucinous Neoplasm

MalaCards integrated aliases for Pancreatic Intraductal Papillary-Mucinous Neoplasm:

Name: Pancreatic Intraductal Papillary-Mucinous Neoplasm 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:7575
NCIt 49 C38342
UMLS 71 C1518869

Summaries for Pancreatic Intraductal Papillary-Mucinous Neoplasm

MalaCards based summary : Pancreatic Intraductal Papillary-Mucinous Neoplasm is related to cystadenocarcinoma and pancreatic ductal carcinoma, and has symptoms including abdominal pain and icterus. An important gene associated with Pancreatic Intraductal Papillary-Mucinous Neoplasm is MUC6 (Mucin 6, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are HIV Life Cycle and Toll-like Receptor Signaling Pathway. The drugs Pancrelipase and pancreatin have been mentioned in the context of this disorder. Affiliated tissues include pancreas, colon and ovary, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Diseases related to Pancreatic Intraductal Papillary-Mucinous Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 148)
# Related Disease Score Top Affiliating Genes
1 cystadenocarcinoma 30.4 MUC5AC MUC1 HRAS
2 pancreatic ductal carcinoma 30.2 SMAD4 MUC6 MUC5AC MUC1
3 pancreatic ductal adenocarcinoma 29.9 SMAD4 MUC1 KRAS HRAS
4 mucinous cystadenocarcinoma 29.9 SMAD4 MUC1
5 pancreatitis 29.7 SMAD4 KRAS HRAS
6 lynch syndrome 29.5 SMAD4 RNF43 KRAS HRAS
7 adenoma 29.4 SMAD4 MUC6 MUC5AC MUC1 KRAS GNAS
8 adenocarcinoma 29.3 SMAD4 MUC1 KRAS HRAS GNAS CDX2
9 pancreatic cancer 28.9 SMAD4 MUC6 MUC5AC MUC1 KRAS HRAS
10 pancreatic adenocarcinoma 28.6 SMAD4 MUC6 MUC5AC MUC1 KRAS HRAS
11 acute pancreatitis 10.5
12 autoimmune pancreatitis 10.4
13 igg4-related disease 10.4
14 in situ carcinoma 10.4
15 anal canal adenocarcinoma 10.4 MUC5AC CDX2
16 mucinous ovarian cystadenoma 10.4 MUC5AC CDX2
17 bile duct mucinous adenocarcinoma 10.4 MUC5AC MUC1
18 pancreatic foamy gland adenocarcinoma 10.3 MUC1 CDX2
19 bile duct mucoepidermoid carcinoma 10.3 MUC5AC MUC1
20 mucinous tubular and spindle renal cell carcinoma 10.3 MUC6 MUC1
21 ovarian mucinous adenocarcinoma 10.3 MUC5AC CDX2
22 krukenberg carcinoma 10.3 MUC1 CDX2
23 epstein-barr virus-associated gastric carcinoma 10.3 MUC6 MUC5AC
24 pancreatic mucinous cystadenoma 10.3 MUC5AC MUC1
25 limbal stem cell deficiency 10.3 MUC5AC MUC1
26 pelvic lipomatosis 10.3 MUC5AC CDX2
27 bile reflux 10.3 MUC5AC CDX2
28 polyposis, skin pigmentation, alopecia, and fingernail changes 10.3 SMAD4 MUC5AC
29 colorectal cancer, hereditary nonpolyposis, type 8 10.3 MUC5AC MUC1
30 colorectal adenoma 10.3
31 alcoholic pancreatitis 10.3
32 pancreatic intraductal papillary-mucinous adenoma 10.3
33 cholangitis 10.3
34 pulmonary embolism 10.3
35 recurrent acute pancreatitis 10.3
36 thrombotic microangiopathy 10.3
37 complete androgen insensitivity syndrome 10.3 MUC5AC MUC1
38 microcystic adenoma 10.3 MUC6 MUC1
39 hepatoid adenocarcinoma 10.3 MUC1 CDX2
40 gastric tubular adenocarcinoma 10.2 MUC6 MUC5AC CDX2
41 endocervical carcinoma 10.2 MUC6 MUC5AC CDX2
42 microinvasive gastric cancer 10.2 MUC6 MUC5AC CDX2
43 meconium ileus 10.2 MUC5AC MUC1
44 mucinous bronchioloalveolar adenocarcinoma 10.2 MUC1 CDX2
45 bile duct cystadenocarcinoma 10.2 MUC6 MUC5AC MUC1
46 solid adenocarcinoma with mucin production 10.2 MUC6 MUC5AC MUC1
47 paget disease, extramammary 10.2 MUC5AC MUC1
48 chronic ethmoiditis 10.2 MUC6 MUC5AC MUC1
49 urachal adenocarcinoma 10.2 KRAS GNAS
50 osteofibrous dysplasia 10.2 MUC1 GNAS

Graphical network of the top 20 diseases related to Pancreatic Intraductal Papillary-Mucinous Neoplasm:



Diseases related to Pancreatic Intraductal Papillary-Mucinous Neoplasm

Symptoms & Phenotypes for Pancreatic Intraductal Papillary-Mucinous Neoplasm

UMLS symptoms related to Pancreatic Intraductal Papillary-Mucinous Neoplasm:


abdominal pain, icterus

GenomeRNAi Phenotypes related to Pancreatic Intraductal Papillary-Mucinous Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.47 HRAS KRAS MUC1
2 Decreased viability GR00106-A-0 9.47 KRAS
3 Decreased viability GR00221-A-1 9.47 HRAS KRAS
4 Decreased viability GR00221-A-2 9.47 HRAS KRAS
5 Decreased viability GR00221-A-3 9.47 HRAS
6 Decreased viability GR00301-A 9.47 KRAS
7 Decreased viability GR00381-A-1 9.47 KRAS
8 Decreased viability GR00402-S-2 9.47 HRAS KRAS MUC1

MGI Mouse Phenotypes related to Pancreatic Intraductal Papillary-Mucinous Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.5 A4GNT CDX2 HRAS KRAS MUC5AC RNF43
2 neoplasm MP:0002006 9.17 A4GNT CDX2 GNAS HRAS KRAS RNF43

Drugs & Therapeutics for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Drugs for Pancreatic Intraductal Papillary-Mucinous Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pancrelipase Approved, Investigational 53608-75-6
2 pancreatin

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Diagnosis of Pancreatic Cystic Lesions With EUS-FNA and Cross-sectional Imaging - A Report of Accuracy Active, not recruiting NCT03884179

Search NIH Clinical Center for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Genetic Tests for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Anatomical Context for Pancreatic Intraductal Papillary-Mucinous Neoplasm

MalaCards organs/tissues related to Pancreatic Intraductal Papillary-Mucinous Neoplasm:

40
Pancreas, Colon, Ovary, Appendix, Small Intestine, Lung, Brain

Publications for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Articles related to Pancreatic Intraductal Papillary-Mucinous Neoplasm:

(show top 50) (show all 63)
# Title Authors PMID Year
1
Pancreatic intraductal papillary mucinous neoplasm masquerading as ampullary adenoma: a diagnostic puzzle. 61
31892805 2020
2
Radiological and Pathological Assessment of the 2017 Revised International Association of Pancreatology Consensus Guidelines for Intraductal Papillary Mucinous Neoplasm, With an Emphasis on the Gastric Pyloric Gland Type. 61
32011532 2020
3
Observation or resection of pancreatic intraductal papillary mucinous neoplasm: An ongoing tug of war. 61
31908715 2019
4
Hepatobiliary and Pancreatic: Intraductal papillary mucinous neoplasm rupture: A rare cause of pancreatic fistula. 61
31822035 2019
5
Characterization of Intraductal Papillary Neoplasm of the Bile Duct with Respect to the Histopathologic Similarities to Pancreatic Intraductal Papillary Mucinous Neoplasm. 61
30982236 2019
6
Validation and head-to-head comparison of four models for predicting malignancy of intraductal papillary mucinous neoplasm of the pancreas: A study based on endoscopic ultrasound findings. 61
31798784 2019
7
Targeted next-generation sequencing identifies distinct clinicopathologic and molecular entities of intraductal papillary neoplasms of the bile duct. 61
31231124 2019
8
Pancreatic Intraductal Papillary Mucinous Neoplasm With Elevated Pre-Operative Cystic Carcinoembryonic Antigen Level: A Histopathologic Correlation. 61
31523327 2019
9
Molecular and clinical patterns of local progression in the pancreatic remnant following resection of pancreatic intraductal papillary mucinous neoplasm (IPMN). 61
31070041 2019
10
Metachronous Intraductal Papillary Neoplasm of the Bile Duct and Intraductal Papillary Mucinous Neoplasm of the Pancreas in a Patient Diagnosed With Mucinous Adenocarcinoma. 61
31616721 2019
11
The role of pancreatic juice cytology in the diagnosis of pancreatic intraductal papillary mucinous neoplasm. 61
30168338 2018
12
Increased EZH2 expression during the adenoma-carcinoma sequence in colorectal cancer. 61
30214616 2018
13
The Role of Endoscopic Ultrasonography and Magnetic Resonance Cholangiopancreatography in Patients With Acute Pancreatitis After Negative Computed Tomography Findings of the Etiology. 61
30142119 2018
14
Incisional Malignant Evolution of Pancreatic Intraductal Papillary Mucinous Neoplasm. 61
30454512 2018
15
Intraductal Papillary Mucinous Neoplasms of Minor Salivary Glands With AKT1 p.Glu17Lys Mutation. 61
29738361 2018
16
[Strategy in management of adjacent organ lesion during laparoscopic pancreaticoduodenectomy]. 61
30032534 2018
17
An Appraisal of Current Guidelines for Managing Malignancy in Pancreatic Intraductal Papillary Mucinous Neoplasm. 61
30636939 2018
18
Reduced ╬▒GlcNAc glycosylation on gastric gland mucin is a biomarker of malignant potential for gastric cancer, Barrett's adenocarcinoma, and pancreatic cancer. 61
29658052 2018
19
Management of pancreatic intraductal papillary mucinous neoplasm. 61
29753366 2018
20
Role of SpyGlass-DStm in the preoperative assessment of pancreatic intraductal papillary mucinous neoplasm involving the main pancreatic duct. 61
29730245 2018
21
Double cystic brain metastasis in a patient with stable pancreatic intraductal papillary mucinous neoplasm. 61
29557198 2018
22
Microwave Thermal Ablation in an Unusual Case of Malignant and Locally Advanced Rare Tumor of Pancreas in ASA IV Old Male Patient and Literature Review. 61
29850295 2018
23
Associating pancreaticostomy and biliary-irrigation for staged pancreaticoduodenectomy approach to pancreatic intraductal papillary mucinous neoplasm with recurrent cholangitis and severe jaundice: A case report. 61
27902614 2016
24
Fundic gland differentiation of oncocytic/pancreatobiliary subtypes of pancreatic intraductal papillary mucinous neoplasm. 61
26990132 2016
25
The oncocytic subtype is genetically distinct from other pancreatic intraductal papillary mucinous neoplasm subtypes. 61
27282351 2016
26
Uncommon liver tumors: Case report and literature review. 61
27684838 2016
27
Incidental Regression of a Suspected Pancreatic Intraductal Papillary Mucinous Neoplasm after Nontarget Embolization. 61
27287972 2016
28
Characterization of intraductal papillary neoplasm of bile duct with respect to histopathologic similarities to pancreatic intraductal papillary mucinous neoplasm. 61
27067788 2016
29
Cystic micropapillary neoplasm of peribiliary glands with concomitant perihilar cholangiocarcinoma. 61
26900302 2016
30
Criteria for Determining Malignancy in Pancreatic Intraductal Papillary Mucinous Neoplasm Based on Computed Tomography. 61
28030856 2016
31
KRAS, GNAS, and RNF43 mutations in intraductal papillary mucinous neoplasm of the pancreas: a meta-analysis. 61
27512631 2016
32
A Case Report: Cavitary Infarction Caused by Pulmonary Tumor Thrombotic Microangiopathy in a Patient with Pancreatic Intraductal Papillary Mucinous Neoplasm. 61
26175596 2015
33
Implications of imaging criteria for the management and treatment of intraductal papillary mucinous neoplasms - benign versus malignant findings. 61
25433414 2015
34
[Pancreatic intraductal papillary mucinous neoplasm: Case report and review of the literature]. 61
26076521 2015
35
Pancreatic intraductal papillary mucinous neoplasm in a patient with Lynch syndrome. 61
25759555 2015
36
Clinical significance of GNAS mutation in intraductal papillary mucinous neoplasm of the pancreas with concomitant pancreatic ductal adenocarcinoma. 61
25479586 2015
37
Pancreatic intraductal papillary mucinous neoplasm--where is the challenge? 61
25531503 2015
38
Direct peroral pancreatoscopy with a pediatric gastroscope for preoperative evaluation of the pancreatic duct in a patient with pancreatic intraductal papillary mucinous neoplasm. 61
26671542 2015
39
Pancreatic intraductal papillary mucinous neoplasm invading the duodenum: a case report and a review of the literature. 61
24622089 2014
40
Genome-wide mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin. 61
24944587 2014
41
EZH2 is associated with malignant behavior in pancreatic IPMN via p27Kip1 downregulation. 61
25084021 2014
42
Air in the main pancreatic duct associated with a pancreatic intraductal papillary mucinous neoplasm. 61
26182136 2013
43
Favorable response after gemcitabine-radiotherapy for invasive pancreatic intraductal papillary mucinous neoplasm: a case report. 61
24229021 2013
44
Evaluation of clinical meaning of histological subtypes of intraductal papillary mucinous neoplasm of the pancreas. 61
23462330 2013
45
Management of pancreatic intraductal papillary mucinous neoplasm in an academic hospital (2005-2010): what follow-up for unoperated patients? 61
23160482 2013
46
Is it necessary to follow patients after resection of a benign pancreatic intraductal papillary mucinous neoplasm? 61
23395158 2013
47
Distinctive expression of CD133 between intraductal papillary neoplasms of the bile duct and bile duct adenocarcinomas. 61
22221899 2012
48
CT findings of intraductal papillary neoplasm of the bile duct: assessment with multiphase contrast-enhanced examination using multi-detector CT. 61
21944774 2012
49
Frequency of subtypes of biliary intraductal papillary mucinous neoplasm and their MUC1, MUC2, and DPC4 expression patterns differ from pancreatic intraductal papillary mucinous neoplasm. 61
22112419 2012
50
Cyst-forming intraductal papillary neoplasm of the bile ducts: description of imaging and pathologic aspects. 61
22021503 2011

Variations for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Expression for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Search GEO for disease gene expression data for Pancreatic Intraductal Papillary-Mucinous Neoplasm.

Pathways for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Pathways related to Pancreatic Intraductal Papillary-Mucinous Neoplasm according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.48 SMAD4 RNF43 MUC6 MUC5AC MUC1 KRAS
2
Show member pathways
12.86 SMAD4 KRAS HRAS GNAS CLDN24
3
Show member pathways
12.57 SMAD4 KRAS HRAS CDX2
4
Show member pathways
12.01 KRAS HRAS GNAS
5 12 SMAD4 KRAS GNAS
6
Show member pathways
11.93 KRAS HRAS GNAS
7
Show member pathways
11.9 MUC6 MUC5AC MUC1
8 11.86 SMAD4 KRAS HRAS
9
Show member pathways
11.82 SMAD4 KRAS HRAS
10 11.81 SMAD4 KRAS HRAS
11
Show member pathways
11.72 MUC6 MUC5AC MUC1 A4GNT
12 11.71 KRAS HRAS GNAS
13 11.69 SMAD4 KRAS HRAS
14
Show member pathways
11.65 MUC6 MUC5AC MUC1
15 11.54 SMAD4 KRAS HRAS
16 11.44 KRAS HRAS GNAS
17
Show member pathways
11.43 MUC6 MUC5AC MUC1 KRAS HRAS
18 11.21 KRAS HRAS GNAS
19
Show member pathways
11.03 KRAS HRAS
20 10.95 KRAS HRAS
21 10.93 KRAS HRAS
22 10.85 KRAS HRAS
23 10.61 SMAD4 KRAS HRAS
24 10.52 KRAS HRAS

GO Terms for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Cellular components related to Pancreatic Intraductal Papillary-Mucinous Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.8 MUC6 MUC5AC MUC1

Biological processes related to Pancreatic Intraductal Papillary-Mucinous Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 anterior/posterior pattern specification GO:0009952 9.43 SMAD4 HOXD8 CDX2
2 regulation of long-term neuronal synaptic plasticity GO:0048169 9.32 KRAS HRAS
3 O-glycan processing GO:0016266 9.26 MUC6 MUC5AC MUC1 A4GNT
4 response to isolation stress GO:0035900 9.16 KRAS HRAS
5 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.02 MUC6 MUC5AC MUC1 KRAS HRAS

Sources for Pancreatic Intraductal Papillary-Mucinous Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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