MCID: PNC043
MIFTS: 31

Pancreatic Intraductal Papillary-Mucinous Neoplasm

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Pancreatic Intraductal Papillary-Mucinous Neoplasm

MalaCards integrated aliases for Pancreatic Intraductal Papillary-Mucinous Neoplasm:

Name: Pancreatic Intraductal Papillary-Mucinous Neoplasm 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:7575
NCIt 50 C38342
UMLS 73 C1518869

Summaries for Pancreatic Intraductal Papillary-Mucinous Neoplasm

MalaCards based summary : Pancreatic Intraductal Papillary-Mucinous Neoplasm is related to pancreatitis and microcystic adenoma, and has symptoms including abdominal pain and icterus. An important gene associated with Pancreatic Intraductal Papillary-Mucinous Neoplasm is MUC6 (Mucin 6, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are HIV Life Cycle and CLEC7A (Dectin-1) signaling. The drugs Pancrelipase and Capecitabine have been mentioned in the context of this disorder. Affiliated tissues include brain.

Related Diseases for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Diseases in the Pancreatic Intraductal Papillary-Mucinous Neoplasm family:

Pancreatic Invasive Intraductal Papillary-Mucinous Carcinoma

Diseases related to Pancreatic Intraductal Papillary-Mucinous Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 pancreatitis 10.8
2 microcystic adenoma 10.3 MUC1 MUC6
3 adenomyoma 10.2 MUC1 MUC6
4 villous adenoma 10.2 GNAS MUC1
5 mixed ductal-endocrine carcinoma 10.2 MUC1 MUC6
6 acute pancreatitis 10.1
7 adenocarcinoma 10.1
8 lynch syndrome 10.1
9 alcoholic pancreatitis 10.1
10 duodenitis 10.1
11 cholangitis 10.1
12 osteofibrous dysplasia 10.0 GNAS MUC1
13 mucinous intrahepatic cholangiocarcinoma 9.9 MUC2 MUC6
14 superior mesenteric artery syndrome 9.9 MUC2 MUC6
15 ovarian mucinous neoplasm 9.9 MUC2 MUC6
16 cystic teratoma 9.8 MUC2 MUC6
17 bile duct mucoepidermoid carcinoma 9.8 MUC1 MUC2
18 ampulla of vater adenocarcinoma 9.8 MUC1 MUC2
19 mucinous cystadenocarcinoma 9.8 MUC1 MUC2
20 colloid carcinoma of the pancreas 9.8 MUC1 MUC2
21 meconium ileus 9.8 MUC1 MUC2
22 biliary tract neoplasm 9.7 MUC1 MUC2
23 pancreatic mucinous cystadenoma 9.7 MUC1 MUC2
24 gastrointestinal carcinoma 9.7 MUC1 MUC2
25 tubular adenocarcinoma 9.7 MUC1 MUC2
26 mucinous adenocarcinoma 9.7 MUC1 MUC2
27 epstein-barr virus-associated gastric carcinoma 9.7 MUC2 MUC6
28 papillary adenocarcinoma 9.7 MUC1 MUC2
29 secretory meningioma 9.7 MUC1 MUC2
30 small intestine cancer 9.7 MUC2 MUC6
31 bile duct adenocarcinoma 9.6 MUC1 MUC2
32 cystadenocarcinoma 9.6 MUC1 MUC2
33 cell type benign neoplasm 9.5 GNAS MUC2
34 bile duct carcinoma 9.5 MUC1 MUC2
35 mucoepidermoid carcinoma 9.4 MUC1 MUC2
36 intrahepatic cholangiocarcinoma 9.3 MUC1 MUC2
37 chronic ethmoiditis 9.3 MUC1 MUC2 MUC6
38 tn polyagglutination syndrome 9.3 MUC1 MUC2 MUC6
39 bile duct cystadenocarcinoma 9.3 MUC1 MUC2 MUC6
40 ampulla of vater neoplasm 9.3 MUC1 MUC2 MUC6
41 mucinous tubular and spindle renal cell carcinoma 9.3 MUC1 MUC2 MUC6
42 biliary papillomatosis 9.3 MUC1 MUC2 MUC6
43 ethmoid sinusitis 9.3 MUC1 MUC2 MUC6
44 duodenum cancer 9.3 MUC1 MUC2 MUC6
45 pseudomyxoma peritonei 9.3 MUC1 MUC2 MUC6
46 gastric tubular adenocarcinoma 9.3 MUC1 MUC2 MUC6
47 signet ring cell adenocarcinoma 9.3 MUC1 MUC2 MUC6
48 small intestinal adenocarcinoma 9.3 MUC1 MUC2 MUC6
49 cystadenoma 9.3 MUC1 MUC2 MUC6
50 colorectal cancer 1 9.3 MUC1 MUC2 MUC6

Graphical network of the top 20 diseases related to Pancreatic Intraductal Papillary-Mucinous Neoplasm:



Diseases related to Pancreatic Intraductal Papillary-Mucinous Neoplasm

Symptoms & Phenotypes for Pancreatic Intraductal Papillary-Mucinous Neoplasm

UMLS symptoms related to Pancreatic Intraductal Papillary-Mucinous Neoplasm:


abdominal pain, icterus

Drugs & Therapeutics for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Drugs for Pancreatic Intraductal Papillary-Mucinous Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pancrelipase Approved, Investigational Phase 3,Not Applicable 53608-75-6
2
Capecitabine Approved, Investigational Phase 3 154361-50-9 60953
3
Gemcitabine Approved Phase 3 95058-81-4 60750
4
Fluorouracil Approved Phase 3 51-21-8 3385
5 pancreatin Phase 3,Not Applicable
6 Anti-Infective Agents Phase 3,Not Applicable
7
Erlotinib Hydrochloride Phase 3 183319-69-9 176871
8 Immunosuppressive Agents Phase 3
9 Protein Kinase Inhibitors Phase 3
10 Antimetabolites Phase 3
11 Antiviral Agents Phase 3
12 Antimetabolites, Antineoplastic Phase 3
13
Paclitaxel Approved, Vet_approved Not Applicable 33069-62-4 36314
14
Ethanol Approved Not Applicable 64-17-5 702
15 Central Nervous System Depressants Not Applicable
16 Albumin-Bound Paclitaxel Not Applicable
17 Gastrointestinal Agents Not Applicable
18 Anti-Infective Agents, Local Not Applicable
19 Antimitotic Agents Not Applicable
20 Antineoplastic Agents, Phytogenic Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Gemcitabine Hydrochloride With or Without Erlotinib Hydrochloride Followed by the Same Chemotherapy Regimen With or Without Radiation Therapy and Capecitabine or Fluorouracil in Treating Patients With Pancreatic Cancer That Has Been Removed by Surgery Active, not recruiting NCT01013649 Phase 3 Capecitabine;Chemotherapy;Erlotinib Hydrochloride;Fluorouracil;Gemcitabine Hydrochloride
2 Endoscopic Ultrasound (EUS)-Guided Ablation of Pancreatic Cysts Recruiting NCT01643460 Not Applicable
3 DCE MRI in Diagnosing Patients With Pancreatic Cancer Recruiting NCT02070705 Not Applicable
4 High Volume Washing of the Abdomen in Increasing Survival After Surgery in Patients With Pancreatic Cancer That Can Be Removed by Surgery Recruiting NCT02757859 Not Applicable

Search NIH Clinical Center for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Genetic Tests for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Anatomical Context for Pancreatic Intraductal Papillary-Mucinous Neoplasm

MalaCards organs/tissues related to Pancreatic Intraductal Papillary-Mucinous Neoplasm:

41
Brain

Publications for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Articles related to Pancreatic Intraductal Papillary-Mucinous Neoplasm:

(show all 27)
# Title Authors Year
1
Management of pancreatic intraductal papillary mucinous neoplasm. ( 29753366 )
2018
2
Double cystic brain metastasis in a patient with stable pancreatic intraductal papillary mucinous neoplasm. ( 29557198 )
2018
3
Role of SpyGlass-DS<sup>tm</sup> in the preoperative assessment of pancreatic intraductal papillary mucinous neoplasm involving the main pancreatic duct. ( 29730245 )
2018
4
The oncocytic subtype is genetically distinct from other pancreatic intraductal papillary mucinous neoplasm subtypes. ( 27282351 )
2016
5
Fundic gland differentiation of oncocytic/pancreatobiliary subtypes of pancreatic intraductal papillary mucinous neoplasm. ( 26990132 )
2016
6
Characterization of intraductal papillary neoplasm of bile duct with respect to histopathologic similarities to pancreatic intraductal papillary mucinous neoplasm. ( 27067788 )
2016
7
Associating pancreaticostomy and biliary-irrigation for staged pancreaticoduodenectomy approach to pancreatic intraductal papillary mucinous neoplasm with recurrent cholangitis and severe jaundice: A case report. ( 27902614 )
2016
8
Criteria for Determining Malignancy in Pancreatic Intraductal Papillary Mucinous Neoplasm Based on Computed Tomography. ( 28030856 )
2016
9
Incidental Regression of a Suspected Pancreatic Intraductal Papillary Mucinous Neoplasm after Nontarget Embolization. ( 27287972 )
2016
10
Direct peroral pancreatoscopy with a pediatric gastroscope for preoperative evaluation of the pancreatic duct in a patient with pancreatic intraductal papillary mucinous neoplasm. ( 26671542 )
2015
11
GNAS mutation is a frequent event in pancreatic intraductal papillary mucinous neoplasms and associated adenocarcinomas. ( 25796395 )
2015
12
Pancreatic intraductal papillary mucinous neoplasm--where is the challenge? ( 25531503 )
2015
13
Pancreatic intraductal papillary mucinous neoplasm in a patient with Lynch syndrome. ( 25759555 )
2015
14
A Case Report: Cavitary Infarction Caused by Pulmonary Tumor Thrombotic Microangiopathy in a Patient with Pancreatic Intraductal Papillary Mucinous Neoplasm. ( 26175596 )
2015
15
Pancreatic intraductal papillary mucinous neoplasm invading the duodenum: a case report and a review of the literature. ( 24622089 )
2014
16
The good, the bad and the ugly: a tale of miR-101, miR-21 and miR-155 in pancreatic intraductal papillary mucinous neoplasms. ( 23139258 )
2013
17
Air in the main pancreatic duct associated with a pancreatic intraductal papillary mucinous neoplasm. ( 26182136 )
2013
18
Is it necessary to follow patients after resection of a benign pancreatic intraductal papillary mucinous neoplasm? ( 23395158 )
2013
19
Favorable response after gemcitabine-radiotherapy for invasive pancreatic intraductal papillary mucinous neoplasm: a case report. ( 24229021 )
2013
20
Management of pancreatic intraductal papillary mucinous neoplasm in an academic hospital (2005-2010): what follow-up for unoperated patients? ( 23160482 )
2013
21
Frequency of subtypes of biliary intraductal papillary mucinous neoplasm and their MUC1, MUC2, and DPC4 expression patterns differ from pancreatic intraductal papillary mucinous neoplasm. ( 22112419 )
2012
22
Endoscopic ultrasound (EUS) aspect of duodenal bulb invasion by multifocal malignant pancreatic intraductal papillary mucinous neoplasm (IPMN). ( 21837609 )
2011
23
Pancreatic intraductal papillary mucinous neoplasm with concomitant heterotopic pancreatic cystic neoplasia of the stomach: a case report and review of the literature. ( 20205774 )
2010
24
The utility of F-18 FDG PET/CT in the evaluation of pancreatic intraductal papillary mucinous neoplasm. ( 20838285 )
2010
25
Plectin-1 is a biomarker of malignant pancreatic intraductal papillary mucinous neoplasms. ( 19760374 )
2009
26
Surgical decompression in the patients of pancreatic intraductal papillary mucinous neoplasm. ( 18265673 )
2007
27
Pathologic features of mucin-producing bile duct tumors: two histopathologic categories as counterparts of pancreatic intraductal papillary-mucinous neoplasms. ( 15104295 )
2004

Variations for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Expression for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Search GEO for disease gene expression data for Pancreatic Intraductal Papillary-Mucinous Neoplasm.

Pathways for Pancreatic Intraductal Papillary-Mucinous Neoplasm

GO Terms for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Cellular components related to Pancreatic Intraductal Papillary-Mucinous Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.35 GNAS MUC1 MUC2 MUC6 RNF43
2 Golgi lumen GO:0005796 8.8 MUC1 MUC2 MUC6

Biological processes related to Pancreatic Intraductal Papillary-Mucinous Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 maintenance of gastrointestinal epithelium GO:0030277 9.16 MUC2 MUC6
2 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.13 MUC1 MUC2 MUC6
3 O-glycan processing GO:0016266 8.8 MUC1 MUC2 MUC6

Sources for Pancreatic Intraductal Papillary-Mucinous Neoplasm

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10 dbSNP
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17 ExPASy
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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