MCID: PNC043
MIFTS: 30

Pancreatic Intraductal Papillary-Mucinous Neoplasm

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Pancreatic Intraductal Papillary-Mucinous Neoplasm

MalaCards integrated aliases for Pancreatic Intraductal Papillary-Mucinous Neoplasm:

Name: Pancreatic Intraductal Papillary-Mucinous Neoplasm 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:7575
NCIt 50 C38342
UMLS 73 C1518869

Summaries for Pancreatic Intraductal Papillary-Mucinous Neoplasm

MalaCards based summary : Pancreatic Intraductal Papillary-Mucinous Neoplasm is related to acute pancreatitis and lynch syndrome, and has symptoms including abdominal pain and icterus. An important gene associated with Pancreatic Intraductal Papillary-Mucinous Neoplasm is MUC6 (Mucin 6, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are HIV Life Cycle and CLEC7A (Dectin-1) signaling. The drugs Pancrelipase and Capecitabine have been mentioned in the context of this disorder. Affiliated tissues include brain, pancreas and small intestine, and related phenotype is neoplasm.

Related Diseases for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Diseases in the Pancreatic Intraductal Papillary-Mucinous Neoplasm family:

Pancreatic Invasive Intraductal Papillary-Mucinous Carcinoma

Diseases related to Pancreatic Intraductal Papillary-Mucinous Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 acute pancreatitis 10.3
2 lynch syndrome 10.3
3 alcoholic pancreatitis 10.3
4 pancreatitis 10.3
5 cholangitis 10.3
6 recurrent acute pancreatitis 10.3
7 mucinous intrahepatic cholangiocarcinoma 10.1 MUC2 MUC6
8 small intestine adenocarcinoma 10.1 MUC2 MUC6
9 duodenum adenocarcinoma 10.0 MUC2 MUC6
10 superior mesenteric artery syndrome 10.0 MUC2 MUC6
11 ovarian mucinous neoplasm 10.0 MUC2 MUC6
12 cystic teratoma 10.0 MUC2 MUC6
13 solid adenocarcinoma with mucin production 10.0 MUC1 MUC6
14 microcystic adenoma 10.0 MUC1 MUC6
15 bronchiolo-alveolar adenocarcinoma 10.0 MUC2 MUC6
16 adenomyoma 10.0 MUC1 MUC6
17 epstein-barr virus-associated gastric carcinoma 10.0 MUC2 MUC6
18 villous adenoma 9.9 GNAS MUC1
19 mixed ductal-endocrine carcinoma 9.9 MUC1 MUC6
20 small intestine cancer 9.9 MUC2 MUC6
21 cystadenocarcinoma 9.9 MUC1 MUC2
22 tubular adenocarcinoma 9.9 MUC1 MUC2
23 spindle cell sarcoma 9.9 CDKN1B MUC1
24 stomach disease 9.9 MUC2 MUC6
25 appendix disease 9.9 GNAS MUC2 MUC6
26 intrahepatic cholangiocarcinoma 9.9 MUC1 MUC2
27 osteofibrous dysplasia 9.9 GNAS MUC1
28 bile duct mucoepidermoid carcinoma 9.9 MUC1 MUC2
29 mucoepidermoid carcinoma 9.9 MUC1 MUC2
30 multiple endocrine neoplasia, type i 9.9 CDKN1B GNAS
31 ampulla of vater adenocarcinoma 9.9 MUC1 MUC2
32 colloid carcinoma of the pancreas 9.9 MUC1 MUC2
33 mucinous cystadenocarcinoma 9.9 MUC1 MUC2
34 pancreatic mucinous cystadenoma 9.9 MUC1 MUC2
35 meconium ileus 9.9 MUC1 MUC2
36 biliary tract neoplasm 9.9 MUC1 MUC2
37 mucinous adenocarcinoma 9.8 MUC1 MUC2
38 papillary adenocarcinoma 9.8 MUC1 MUC2
39 bile duct adenocarcinoma 9.8 MUC1 MUC2
40 chronic ethmoiditis 9.8 MUC1 MUC2 MUC6
41 bile duct cystadenocarcinoma 9.8 MUC1 MUC2 MUC6
42 mucinous tubular and spindle renal cell carcinoma 9.8 MUC1 MUC2 MUC6
43 biliary papillomatosis 9.8 MUC1 MUC2 MUC6
44 ethmoid sinusitis 9.8 MUC1 MUC2 MUC6
45 duodenal disease 9.8 MUC1 MUC2 MUC6
46 duodenum cancer 9.8 MUC1 MUC2 MUC6
47 pseudomyxoma peritonei 9.8 MUC1 MUC2 MUC6
48 gastric tubular adenocarcinoma 9.8 MUC1 MUC2 MUC6
49 tn polyagglutination syndrome 9.8 MUC1 MUC2 MUC6
50 signet ring cell adenocarcinoma 9.8 MUC1 MUC2 MUC6

Graphical network of the top 20 diseases related to Pancreatic Intraductal Papillary-Mucinous Neoplasm:



Diseases related to Pancreatic Intraductal Papillary-Mucinous Neoplasm

Symptoms & Phenotypes for Pancreatic Intraductal Papillary-Mucinous Neoplasm

UMLS symptoms related to Pancreatic Intraductal Papillary-Mucinous Neoplasm:


abdominal pain, icterus

MGI Mouse Phenotypes related to Pancreatic Intraductal Papillary-Mucinous Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 CDKN1B GNAS MUC2 RNF43

Drugs & Therapeutics for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Drugs for Pancreatic Intraductal Papillary-Mucinous Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pancrelipase Approved, Investigational Phase 3,Not Applicable 53608-75-6
2
Capecitabine Approved, Investigational Phase 3 154361-50-9 60953
3
Gemcitabine Approved Phase 3 95058-81-4 60750
4
Fluorouracil Approved Phase 3 51-21-8 3385
5 Anti-Infective Agents Phase 3,Not Applicable
6 pancreatin Phase 3,Not Applicable
7 Antiviral Agents Phase 3
8 Antimetabolites Phase 3
9 Immunologic Factors Phase 3
10 Antimetabolites, Antineoplastic Phase 3
11 Protein Kinase Inhibitors Phase 3
12
Erlotinib Hydrochloride Phase 3 183319-69-9 176871
13 Immunosuppressive Agents Phase 3
14
Paclitaxel Approved, Vet_approved Not Applicable 33069-62-4 36314
15
Ethanol Approved Not Applicable 64-17-5 702
16 Antineoplastic Agents, Phytogenic Not Applicable
17 Antimitotic Agents Not Applicable
18 Anti-Infective Agents, Local Not Applicable
19 Central Nervous System Depressants Not Applicable
20 Albumin-Bound Paclitaxel Not Applicable
21 Pharmaceutical Solutions Not Applicable
22 Parenteral Nutrition Solutions Not Applicable
23 Ferrosoferric Oxide Not Applicable
24 Hematinics Not Applicable
25 Gastrointestinal Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Gemcitabine Hydrochloride With or Without Erlotinib Hydrochloride Followed by the Same Chemotherapy Regimen With or Without Radiation Therapy and Capecitabine or Fluorouracil in Treating Patients With Pancreatic Cancer That Has Been Removed by Surgery Active, not recruiting NCT01013649 Phase 3 Capecitabine;Chemotherapy;Erlotinib Hydrochloride;Fluorouracil;Gemcitabine Hydrochloride
2 Endoscopic Ultrasound (EUS)-Guided Ablation of Pancreatic Cysts Recruiting NCT01643460 Not Applicable
3 DCE MRI in Patients With Pancreatic Cancer Recruiting NCT02070705 Not Applicable Ferumoxytol
4 High Volume Washing of the Abdomen in Increasing Survival After Surgery in Patients With Pancreatic Cancer That Can Be Removed by Surgery Recruiting NCT02757859 Not Applicable
5 Ultra-High Resolution Optical Coherence Tomography in Detecting Micrometer Sized Early Stage Pancreatic Cancer in Participants With Pancreatic Cancer Not yet recruiting NCT03711890 Not Applicable

Search NIH Clinical Center for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Genetic Tests for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Anatomical Context for Pancreatic Intraductal Papillary-Mucinous Neoplasm

MalaCards organs/tissues related to Pancreatic Intraductal Papillary-Mucinous Neoplasm:

41
Brain, Pancreas, Small Intestine, Appendix

Publications for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Articles related to Pancreatic Intraductal Papillary-Mucinous Neoplasm:

(show all 25)
# Title Authors Year
1
Management of pancreatic intraductal papillary mucinous neoplasm. ( 29753366 )
2018
2
Double cystic brain metastasis in a patient with stable pancreatic intraductal papillary mucinous neoplasm. ( 29557198 )
2018
3
Role of SpyGlass-DS<sup>tm</sup> in the preoperative assessment of pancreatic intraductal papillary mucinous neoplasm involving the main pancreatic duct. ( 29730245 )
2018
4
The role of pancreatic juice cytology in the diagnosis of pancreatic intraductal papillary mucinous neoplasm. ( 30168338 )
2018
5
Incisional Malignant Evolution of Pancreatic Intraductal Papillary Mucinous Neoplasm. ( 30454512 )
2018
6
The oncocytic subtype is genetically distinct from other pancreatic intraductal papillary mucinous neoplasm subtypes. ( 27282351 )
2016
7
Fundic gland differentiation of oncocytic/pancreatobiliary subtypes of pancreatic intraductal papillary mucinous neoplasm. ( 26990132 )
2016
8
Characterization of intraductal papillary neoplasm of bile duct with respect to histopathologic similarities to pancreatic intraductal papillary mucinous neoplasm. ( 27067788 )
2016
9
Associating pancreaticostomy and biliary-irrigation for staged pancreaticoduodenectomy approach to pancreatic intraductal papillary mucinous neoplasm with recurrent cholangitis and severe jaundice: A case report. ( 27902614 )
2016
10
Criteria for Determining Malignancy in Pancreatic Intraductal Papillary Mucinous Neoplasm Based on Computed Tomography. ( 28030856 )
2016
11
Incidental Regression of a Suspected Pancreatic Intraductal Papillary Mucinous Neoplasm after Nontarget Embolization. ( 27287972 )
2016
12
Direct peroral pancreatoscopy with a pediatric gastroscope for preoperative evaluation of the pancreatic duct in a patient with pancreatic intraductal papillary mucinous neoplasm. ( 26671542 )
2015
13
Pancreatic intraductal papillary mucinous neoplasm--where is the challenge? ( 25531503 )
2015
14
Pancreatic intraductal papillary mucinous neoplasm in a patient with Lynch syndrome. ( 25759555 )
2015
15
A Case Report: Cavitary Infarction Caused by Pulmonary Tumor Thrombotic Microangiopathy in a Patient with Pancreatic Intraductal Papillary Mucinous Neoplasm. ( 26175596 )
2015
16
Pancreatic intraductal papillary mucinous neoplasm invading the duodenum: a case report and a review of the literature. ( 24622089 )
2014
17
Air in the main pancreatic duct associated with a pancreatic intraductal papillary mucinous neoplasm. ( 26182136 )
2013
18
Is it necessary to follow patients after resection of a benign pancreatic intraductal papillary mucinous neoplasm? ( 23395158 )
2013
19
Favorable response after gemcitabine-radiotherapy for invasive pancreatic intraductal papillary mucinous neoplasm: a case report. ( 24229021 )
2013
20
Management of pancreatic intraductal papillary mucinous neoplasm in an academic hospital (2005-2010): what follow-up for unoperated patients? ( 23160482 )
2013
21
Frequency of subtypes of biliary intraductal papillary mucinous neoplasm and their MUC1, MUC2, and DPC4 expression patterns differ from pancreatic intraductal papillary mucinous neoplasm. ( 22112419 )
2012
22
Endoscopic ultrasound (EUS) aspect of duodenal bulb invasion by multifocal malignant pancreatic intraductal papillary mucinous neoplasm (IPMN). ( 21837609 )
2011
23
Pancreatic intraductal papillary mucinous neoplasm with concomitant heterotopic pancreatic cystic neoplasia of the stomach: a case report and review of the literature. ( 20205774 )
2010
24
The utility of F-18 FDG PET/CT in the evaluation of pancreatic intraductal papillary mucinous neoplasm. ( 20838285 )
2010
25
Surgical decompression in the patients of pancreatic intraductal papillary mucinous neoplasm. ( 18265673 )
2007

Variations for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Expression for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Search GEO for disease gene expression data for Pancreatic Intraductal Papillary-Mucinous Neoplasm.

Pathways for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Pathways related to Pancreatic Intraductal Papillary-Mucinous Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.09 CDKN1B MUC1 MUC2 MUC6 RNF43
2
Show member pathways
11.84 MUC1 MUC2 MUC6
3
Show member pathways
11.59 MUC1 MUC2 MUC6
4 11.41 CDKN1B GNAS
5 11.39 GNAS MUC2
6
Show member pathways
11.3 MUC1 MUC2 MUC6
7 11.2 CDKN1B GNAS
8
Show member pathways
10.84 MUC1 MUC2 MUC6
9 10.82 CDKN1B GNAS

GO Terms for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Cellular components related to Pancreatic Intraductal Papillary-Mucinous Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.8 MUC1 MUC2 MUC6

Biological processes related to Pancreatic Intraductal Papillary-Mucinous Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.26 CDKN1B MUC1
2 maintenance of gastrointestinal epithelium GO:0030277 9.16 MUC2 MUC6
3 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.13 MUC1 MUC2 MUC6
4 O-glycan processing GO:0016266 8.8 MUC1 MUC2 MUC6

Sources for Pancreatic Intraductal Papillary-Mucinous Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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