MCID: PNC043
MIFTS: 32

Pancreatic Intraductal Papillary-Mucinous Neoplasm

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Pancreatic Intraductal Papillary-Mucinous Neoplasm

MalaCards integrated aliases for Pancreatic Intraductal Papillary-Mucinous Neoplasm:

Name: Pancreatic Intraductal Papillary-Mucinous Neoplasm 12 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:7575
NCIt 50 C38342
UMLS 72 C1518869

Summaries for Pancreatic Intraductal Papillary-Mucinous Neoplasm

MalaCards based summary : Pancreatic Intraductal Papillary-Mucinous Neoplasm is related to adenoma and adenocarcinoma, and has symptoms including abdominal pain and icterus. An important gene associated with Pancreatic Intraductal Papillary-Mucinous Neoplasm is GNAS (GNAS Complex Locus), and among its related pathways/superpathways are Pathways in cancer and Gastric cancer. The drugs Pancrelipase and pancreatin have been mentioned in the context of this disorder. Affiliated tissues include pancreas, brain and liver, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Related Diseases for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Diseases related to Pancreatic Intraductal Papillary-Mucinous Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 adenoma 30.2 SMAD4 KRAS GNAS
2 adenocarcinoma 30.2 SMAD4 KRAS GNAS
3 pancreatic ductal carcinoma 30.1 SMAD4 MUC6
4 pancreatic cancer 10.7
5 autoimmune pancreatitis 10.5
6 pancreatic ductal adenocarcinoma 10.5
7 pancreatic adenocarcinoma 10.5
8 acute pancreatitis 10.4
9 pancreatitis 10.4
10 in situ carcinoma 10.4
11 recurrent acute pancreatitis 10.4
12 pancreas, annular 10.3
13 colorectal adenoma 10.3
14 igg4-related disease 10.3
15 cystadenocarcinoma 10.3
16 mucinous cystadenocarcinoma 10.3
17 lynch syndrome 10.3
18 alcoholic pancreatitis 10.3
19 pancreatic intraductal papillary-mucinous adenoma 10.3
20 cholangitis 10.3
21 pulmonary embolism 10.3
22 autoimmune pancreatitis type 1 10.3
23 thrombotic microangiopathy 10.3
24 urachal adenocarcinoma 10.2 KRAS GNAS
25 ovarian cystadenocarcinoma 10.2 KRAS GNAS
26 hyperplastic polyposis syndrome 10.1 RNF43 KRAS
27 mucinous intrahepatic cholangiocarcinoma 10.1 MUC6 CDX2
28 cervical polyp 10.1 MUC6 CDX2
29 superior mesenteric artery syndrome 10.1 MUC6 CDX2
30 ovarian mucinous neoplasm 10.0 MUC6 CDX2
31 cell type benign neoplasm 10.0 KRAS GNAS
32 endocervical adenocarcinoma 10.0 MUC6 CDX2
33 intrahepatic cholangiocarcinoma 10.0 KRAS CDX2
34 cystic teratoma 10.0 MUC6 CDX2
35 nasal cavity adenocarcinoma 10.0 KRAS CDX2
36 anal canal adenocarcinoma 10.0 KRAS CDX2
37 gastric tubular adenocarcinoma 10.0 MUC6 CDX2
38 signet ring cell adenocarcinoma 10.0 MUC6 CDX2
39 adenocarcinoma in situ 10.0 KRAS CDX2
40 cecum adenocarcinoma 9.9 KRAS CDX2
41 mucinous adenocarcinoma 9.9 KRAS CDX2
42 intestinal benign neoplasm 9.9 KRAS CDX2
43 tumor of exocrine pancreas 9.9 RNF43 MUC6 GNAS
44 mutyh-associated polyposis 9.8 SMAD4 KRAS
45 stomach disease 9.8 MUC6 CDX2
46 mixed ductal-endocrine carcinoma 9.8 SMAD4 MUC6
47 colonic disease 9.8 KRAS CDX2
48 colloid carcinoma of the pancreas 9.8 SMAD4 KRAS
49 colorectal adenocarcinoma 9.8 KRAS CDX2
50 appendix cancer 9.7 MUC6 GNAS CDX2

Graphical network of the top 20 diseases related to Pancreatic Intraductal Papillary-Mucinous Neoplasm:



Diseases related to Pancreatic Intraductal Papillary-Mucinous Neoplasm

Symptoms & Phenotypes for Pancreatic Intraductal Papillary-Mucinous Neoplasm

UMLS symptoms related to Pancreatic Intraductal Papillary-Mucinous Neoplasm:


abdominal pain, icterus

MGI Mouse Phenotypes related to Pancreatic Intraductal Papillary-Mucinous Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.56 CDX2 KRAS RNF43 SMAD4
2 endocrine/exocrine gland MP:0005379 9.55 CDX2 GNAS KRAS RNF43 SMAD4
3 limbs/digits/tail MP:0005371 9.26 CDX2 GNAS KRAS SMAD4
4 neoplasm MP:0002006 9.02 CDX2 GNAS KRAS RNF43 SMAD4

Drugs & Therapeutics for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Drugs for Pancreatic Intraductal Papillary-Mucinous Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pancrelipase Approved, Investigational 53608-75-6
2 pancreatin

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Diagnosis of Pancreatic Cystic Lesions With EUS-FNA and Cross-sectional Imaging - A Report of Accuracy Active, not recruiting NCT03884179

Search NIH Clinical Center for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Genetic Tests for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Anatomical Context for Pancreatic Intraductal Papillary-Mucinous Neoplasm

MalaCards organs/tissues related to Pancreatic Intraductal Papillary-Mucinous Neoplasm:

41
Pancreas, Brain, Liver, Salivary Gland

Publications for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Articles related to Pancreatic Intraductal Papillary-Mucinous Neoplasm:

(show top 50) (show all 56)
# Title Authors PMID Year
1
Targeted next-generation sequencing identifies distinct clinicopathologic and molecular entities of intraductal papillary neoplasms of the bile duct. 38
31231124 2019
2
Characterization of Intraductal Papillary Neoplasm of the Bile Duct with Respect to the Histopathologic Similarities to Pancreatic Intraductal Papillary Mucinous Neoplasm. 38
30982236 2019
3
Molecular and clinical patterns of local progression in the pancreatic remnant following resection of pancreatic intraductal papillary mucinous neoplasm (IPMN). 38
31070041 2019
4
The role of pancreatic juice cytology in the diagnosis of pancreatic intraductal papillary mucinous neoplasm. 38
30168338 2018
5
Increased EZH2 expression during the adenoma-carcinoma sequence in colorectal cancer. 38
30214616 2018
6
The Role of Endoscopic Ultrasonography and Magnetic Resonance Cholangiopancreatography in Patients With Acute Pancreatitis After Negative Computed Tomography Findings of the Etiology. 38
30142119 2018
7
Incisional Malignant Evolution of Pancreatic Intraductal Papillary Mucinous Neoplasm. 38
30454512 2018
8
Intraductal Papillary Mucinous Neoplasms of Minor Salivary Glands With AKT1 p.Glu17Lys Mutation. 38
29738361 2018
9
[Strategy in management of adjacent organ lesion during laparoscopic pancreaticoduodenectomy]. 38
30032534 2018
10
An Appraisal of Current Guidelines for Managing Malignancy in Pancreatic Intraductal Papillary Mucinous Neoplasm. 38
30636939 2018
11
Reduced ╬▒GlcNAc glycosylation on gastric gland mucin is a biomarker of malignant potential for gastric cancer, Barrett's adenocarcinoma, and pancreatic cancer. 38
29658052 2018
12
Role of SpyGlass-DStm in the preoperative assessment of pancreatic intraductal papillary mucinous neoplasm involving the main pancreatic duct. 38
29730245 2018
13
Management of pancreatic intraductal papillary mucinous neoplasm. 38
29753366 2018
14
Double cystic brain metastasis in a patient with stable pancreatic intraductal papillary mucinous neoplasm. 38
29557198 2018
15
Microwave Thermal Ablation in an Unusual Case of Malignant and Locally Advanced Rare Tumor of Pancreas in ASA IV Old Male Patient and Literature Review. 38
29850295 2018
16
Associating pancreaticostomy and biliary-irrigation for staged pancreaticoduodenectomy approach to pancreatic intraductal papillary mucinous neoplasm with recurrent cholangitis and severe jaundice: A case report. 38
27902614 2016
17
Fundic gland differentiation of oncocytic/pancreatobiliary subtypes of pancreatic intraductal papillary mucinous neoplasm. 38
26990132 2016
18
Uncommon liver tumors: Case report and literature review. 38
27684838 2016
19
The oncocytic subtype is genetically distinct from other pancreatic intraductal papillary mucinous neoplasm subtypes. 38
27282351 2016
20
Incidental Regression of a Suspected Pancreatic Intraductal Papillary Mucinous Neoplasm after Nontarget Embolization. 38
27287972 2016
21
Characterization of intraductal papillary neoplasm of bile duct with respect to histopathologic similarities to pancreatic intraductal papillary mucinous neoplasm. 38
27067788 2016
22
Cystic micropapillary neoplasm of peribiliary glands with concomitant perihilar cholangiocarcinoma. 38
26900302 2016
23
Criteria for Determining Malignancy in Pancreatic Intraductal Papillary Mucinous Neoplasm Based on Computed Tomography. 38
28030856 2016
24
KRAS, GNAS, and RNF43 mutations in intraductal papillary mucinous neoplasm of the pancreas: a meta-analysis. 38
27512631 2016
25
A Case Report: Cavitary Infarction Caused by Pulmonary Tumor Thrombotic Microangiopathy in a Patient with Pancreatic Intraductal Papillary Mucinous Neoplasm. 38
26175596 2015
26
Implications of imaging criteria for the management and treatment of intraductal papillary mucinous neoplasms - benign versus malignant findings. 38
25433414 2015
27
[Pancreatic intraductal papillary mucinous neoplasm: Case report and review of the literature]. 38
26076521 2015
28
Clinical significance of GNAS mutation in intraductal papillary mucinous neoplasm of the pancreas with concomitant pancreatic ductal adenocarcinoma. 38
25479586 2015
29
Pancreatic intraductal papillary mucinous neoplasm in a patient with Lynch syndrome. 38
25759555 2015
30
Pancreatic intraductal papillary mucinous neoplasm--where is the challenge? 38
25531503 2015
31
Direct peroral pancreatoscopy with a pediatric gastroscope for preoperative evaluation of the pancreatic duct in a patient with pancreatic intraductal papillary mucinous neoplasm. 38
26671542 2015
32
Pancreatic intraductal papillary mucinous neoplasm invading the duodenum: a case report and a review of the literature. 38
24622089 2014
33
Genome-wide mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin. 38
24944587 2014
34
EZH2 is associated with malignant behavior in pancreatic IPMN via p27Kip1 downregulation. 38
25084021 2014
35
Air in the main pancreatic duct associated with a pancreatic intraductal papillary mucinous neoplasm. 38
26182136 2013
36
Favorable response after gemcitabine-radiotherapy for invasive pancreatic intraductal papillary mucinous neoplasm: a case report. 38
24229021 2013
37
Evaluation of clinical meaning of histological subtypes of intraductal papillary mucinous neoplasm of the pancreas. 38
23462330 2013
38
Management of pancreatic intraductal papillary mucinous neoplasm in an academic hospital (2005-2010): what follow-up for unoperated patients? 38
23160482 2013
39
Is it necessary to follow patients after resection of a benign pancreatic intraductal papillary mucinous neoplasm? 38
23395158 2013
40
Distinctive expression of CD133 between intraductal papillary neoplasms of the bile duct and bile duct adenocarcinomas. 38
22221899 2012
41
CT findings of intraductal papillary neoplasm of the bile duct: assessment with multiphase contrast-enhanced examination using multi-detector CT. 38
21944774 2012
42
Frequency of subtypes of biliary intraductal papillary mucinous neoplasm and their MUC1, MUC2, and DPC4 expression patterns differ from pancreatic intraductal papillary mucinous neoplasm. 38
22112419 2012
43
Cyst-forming intraductal papillary neoplasm of the bile ducts: description of imaging and pathologic aspects. 38
22021503 2011
44
[Malignancy predictive factors in pancreatic intraductal papillary mucinous neoplasm]. 38
21414642 2011
45
A comparative study of intraductal papillary neoplasia of the biliary tract and pancreas. 38
21292296 2011
46
Predicting malignant intraductal papillary mucinous neoplasm: a single-center review. 38
21545902 2011
47
Endoscopic ultrasound (EUS) aspect of duodenal bulb invasion by multifocal malignant pancreatic intraductal papillary mucinous neoplasm (IPMN). 38
21837609 2011
48
The utility of F-18 FDG PET/CT in the evaluation of pancreatic intraductal papillary mucinous neoplasm. 38
20838285 2010
49
Pancreatic intraductal papillary mucinous neoplasm with concomitant heterotopic pancreatic cystic neoplasia of the stomach: a case report and review of the literature. 38
20205774 2010
50
[Intraduct papillar-mucinous pancreatic tumors]. 38
20469708 2009

Variations for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Expression for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Search GEO for disease gene expression data for Pancreatic Intraductal Papillary-Mucinous Neoplasm.

Pathways for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Pathways related to Pancreatic Intraductal Papillary-Mucinous Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.22 SMAD4 KRAS GNAS
2
Show member pathways
12.1 SMAD4 KRAS CDX2
3 11.46 SMAD4 KRAS
4 11.42 SMAD4 KRAS
5 11.35 SMAD4 GNAS
6 11.31 KRAS GNAS
7 11.02 SMAD4 KRAS GNAS
8 10.93 KRAS GNAS
9 10.43 SMAD4 KRAS

GO Terms for Pancreatic Intraductal Papillary-Mucinous Neoplasm

Biological processes related to Pancreatic Intraductal Papillary-Mucinous Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 anterior/posterior pattern specification GO:0009952 9.32 SMAD4 CDX2
2 female pregnancy GO:0007565 9.26 KRAS GNAS
3 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.16 MUC6 KRAS
4 somatic stem cell population maintenance GO:0035019 8.96 SMAD4 CDX2
5 developmental growth GO:0048589 8.62 SMAD4 GNAS

Sources for Pancreatic Intraductal Papillary-Mucinous Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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