MCID: PNC010
MIFTS: 30

Pancreatic Signet Ring Cell Adenocarcinoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Pancreatic Signet Ring Cell Adenocarcinoma

MalaCards integrated aliases for Pancreatic Signet Ring Cell Adenocarcinoma:

Name: Pancreatic Signet Ring Cell Adenocarcinoma 12 15
Pancreatic Signet Ring Cell Carcinoma 12 70
Signet Ring Cell Carcinoma of Pancreas 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3497
NCIt 50 C5720
UMLS 70 C1335317

Summaries for Pancreatic Signet Ring Cell Adenocarcinoma

MalaCards based summary : Pancreatic Signet Ring Cell Adenocarcinoma, also known as pancreatic signet ring cell carcinoma, is related to pancreatic adenocarcinoma and signet ring cell adenocarcinoma, and has symptoms including abdominal pain, pruritus and icterus. An important gene associated with Pancreatic Signet Ring Cell Adenocarcinoma is MUC5AC (Mucin 5AC, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include pancreas, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Pancreatic Signet Ring Cell Adenocarcinoma

Diseases related to Pancreatic Signet Ring Cell Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 246)
# Related Disease Score Top Affiliating Genes
1 pancreatic adenocarcinoma 29.6 TP53 KRAS HRAS
2 signet ring cell adenocarcinoma 28.9 TP53 MUC5AC MUC1 KRAS HRAS
3 pancreatic cancer 28.8 TP53 MUC5AC MUC1 KRAS HRAS
4 pancreatitis 10.2
5 biliary papillomatosis 10.2 MUC5AC MUC1
6 colloid carcinoma of the pancreas 10.1 MUC5AC MUC1
7 chronic ethmoiditis 10.1 MUC5AC MUC1
8 urinary bladder villous adenoma 10.1 MUC5AC MUC1
9 mucinous intrahepatic cholangiocarcinoma 10.1 MUC5AC MUC1
10 bile duct cystadenocarcinoma 10.1 MUC5AC MUC1
11 bile duct mucoepidermoid carcinoma 10.1 MUC5AC MUC1
12 conjunctival degeneration 10.1 TP53 MUC5AC
13 pancreatic mucinous cystadenoma 10.1 MUC5AC MUC1
14 cystadenoma 10.1 MUC5AC MUC1
15 filamentary keratitis 10.1 MUC5AC MUC1
16 solid adenocarcinoma with mucin production 10.1 MUC5AC MUC1
17 limbal stem cell deficiency 10.1 MUC5AC MUC1
18 acute cholangitis 10.1 MUC5AC MUC1
19 colorectal cancer, hereditary nonpolyposis, type 8 10.1 MUC5AC MUC1
20 pancreatic foamy gland adenocarcinoma 10.1 TP53 MUC1
21 neurofibroma 10.1 TP53 MUC1
22 complete androgen insensitivity syndrome 10.1 MUC5AC MUC1
23 androgen insensitivity syndrome 10.1 MUC5AC MUC1
24 cystadenofibroma 10.1 TP53 MUC1
25 adenofibroma 10.1 TP53 MUC1
26 colorectal cancer 1 10.1 MUC5AC MUC1
27 meconium ileus 10.1 MUC5AC MUC1
28 mammary analogue secretory carcinoma 10.1 TP53 MUC1
29 ovarian serous cystadenofibroma 10.1 TP53 MUC1
30 ampulla of vater adenocarcinoma 10.1 MUC5AC MUC1
31 bile duct adenoma 10.1 TP53 MUC1
32 chordoid glioma 10.1 TP53 MUC1
33 microinvasive gastric cancer 10.1 TP53 MUC5AC
34 spiradenoma 10.1 TP53 MUC1
35 tubular adenocarcinoma 10.1 MUC5AC MUC1
36 cervical adenocarcinoma 10.1 TP53 KRAS
37 sarcomatoid renal cell carcinoma 10.1 TP53 MUC1
38 mature teratoma 10.0 TP53 KRAS
39 papilloma of choroid plexus 10.0 TP53 MUC1
40 lobular neoplasia 10.0 TP53 MUC1
41 thoracic benign neoplasm 10.0 TP53 MUC1
42 breast benign neoplasm 10.0 TP53 MUC1
43 glomus tumor 10.0 TP53 MUC1
44 liver angiosarcoma 10.0 TP53 KRAS
45 syringocystadenoma papilliferum 10.0 MUC1 KRAS
46 endosalpingiosis 10.0 MUC1 KRAS
47 endometrioid ovary carcinoma 10.0 TP53 KRAS
48 benign teratoma 10.0 TP53 MUC1
49 thymic carcinoma 10.0 TP53 MUC1
50 well-differentiated liposarcoma 10.0 TP53 MUC1

Graphical network of the top 20 diseases related to Pancreatic Signet Ring Cell Adenocarcinoma:



Diseases related to Pancreatic Signet Ring Cell Adenocarcinoma

Symptoms & Phenotypes for Pancreatic Signet Ring Cell Adenocarcinoma

UMLS symptoms related to Pancreatic Signet Ring Cell Adenocarcinoma:


abdominal pain; pruritus; icterus

GenomeRNAi Phenotypes related to Pancreatic Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.53 HRAS KRAS MUC1
2 Decreased viability GR00055-A-2 9.53 HRAS KRAS MUC1
3 Decreased viability GR00055-A-3 9.53 KRAS
4 Decreased viability GR00106-A-0 9.53 KRAS
5 Decreased viability GR00221-A-1 9.53 HRAS KRAS
6 Decreased viability GR00221-A-2 9.53 HRAS KRAS
7 Decreased viability GR00221-A-3 9.53 HRAS
8 Decreased viability GR00249-S 9.53 MUC1
9 Decreased viability GR00301-A 9.53 KRAS
10 Decreased viability GR00381-A-1 9.53 KRAS
11 Decreased cell migration GR00055-A-3 8.65 HRAS

MGI Mouse Phenotypes related to Pancreatic Signet Ring Cell Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.92 HRAS KRAS MUC5AC TP53

Drugs & Therapeutics for Pancreatic Signet Ring Cell Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Pancreatic Signet Ring Cell Adenocarcinoma

Genetic Tests for Pancreatic Signet Ring Cell Adenocarcinoma

Anatomical Context for Pancreatic Signet Ring Cell Adenocarcinoma

MalaCards organs/tissues related to Pancreatic Signet Ring Cell Adenocarcinoma:

40
Pancreas

Publications for Pancreatic Signet Ring Cell Adenocarcinoma

Articles related to Pancreatic Signet Ring Cell Adenocarcinoma:

# Title Authors PMID Year
1
Paratesticular tumors. A clinicopathological study from a single tertiary hospital in North India. 61
33189965 2021
2
Primary Pancreatic Signet Ring Cell Carcinoma: A Case Report and Review of the Literature. 61
33569523 2021
3
The Impact of Epidemiological Factors and Treatment Interventions on Survival in Patients With Signet Ring Cell Carcinoma of the Pancreas. 61
29672365 2018
4
Metastatic tumours mimicking vestibular schwannoma. 61
18754073 2008

Variations for Pancreatic Signet Ring Cell Adenocarcinoma

Expression for Pancreatic Signet Ring Cell Adenocarcinoma

Search GEO for disease gene expression data for Pancreatic Signet Ring Cell Adenocarcinoma.

Pathways for Pancreatic Signet Ring Cell Adenocarcinoma

Pathways related to Pancreatic Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.7 TP53 MUC5AC MUC1 KRAS HRAS
2
Show member pathways
13.09 TP53 MUC1 KRAS HRAS
3 12.62 TP53 KRAS HRAS
4 12.55 TP53 KRAS HRAS
5
Show member pathways
12.54 TP53 KRAS HRAS
6
Show member pathways
12.51 TP53 KRAS HRAS
7
Show member pathways
12.5 TP53 KRAS HRAS
8
Show member pathways
12.49 TP53 KRAS HRAS
9
Show member pathways
12.46 TP53 KRAS HRAS
10
Show member pathways
12.44 TP53 KRAS HRAS
11
Show member pathways
12.4 TP53 KRAS HRAS
12
Show member pathways
12.37 TP53 KRAS HRAS
13 12.32 TP53 KRAS HRAS
14
Show member pathways
12.29 TP53 KRAS HRAS
15
Show member pathways
12.22 TP53 KRAS HRAS
16 12.11 TP53 KRAS HRAS
17
Show member pathways
12.09 MUC1 KRAS HRAS
18 12.07 TP53 KRAS HRAS
19 12.06 TP53 KRAS HRAS
20
Show member pathways
12.06 TP53 KRAS HRAS
21
Show member pathways
12.02 TP53 KRAS HRAS
22
Show member pathways
11.92 TP53 KRAS HRAS
23 11.89 TP53 KRAS HRAS
24
Show member pathways
11.85 TP53 KRAS HRAS
25
Show member pathways
11.83 TP53 KRAS HRAS
26
Show member pathways
11.8 TP53 KRAS HRAS
27 11.72 TP53 KRAS HRAS
28
Show member pathways
11.72 TP53 MUC1 KRAS HRAS
29 11.68 TP53 KRAS HRAS
30 11.64 TP53 KRAS HRAS
31 11.59 TP53 KRAS HRAS
32 11.57 KRAS HRAS
33 11.53 TP53 HRAS
34
Show member pathways
11.52 KRAS HRAS
35 11.51 KRAS HRAS
36 11.48 KRAS HRAS
37 11.45 KRAS HRAS
38 11.36 KRAS HRAS
39 11.36 TP53 KRAS HRAS
40
Show member pathways
11.34 MUC5AC MUC1 KRAS HRAS
41 11.32 TP53 HRAS
42 11.31 KRAS HRAS
43 11.28 TP53 KRAS HRAS
44 11.24 KRAS HRAS
45 11.17 KRAS HRAS
46 11.16 TP53 KRAS HRAS
47 11.11 KRAS HRAS
48 11.11 KRAS HRAS
49
Show member pathways
11.09 KRAS HRAS
50
Show member pathways
11.03 KRAS HRAS

GO Terms for Pancreatic Signet Ring Cell Adenocarcinoma

Biological processes related to Pancreatic Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.71 TP53 KRAS HRAS
2 cytokine-mediated signaling pathway GO:0019221 9.65 TP53 MUC1 KRAS
3 positive regulation of MAP kinase activity GO:0043406 9.52 KRAS HRAS
4 O-glycan processing GO:0016266 9.51 MUC5AC MUC1
5 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.49 TP53 MUC1
6 intrinsic apoptotic signaling pathway GO:0097193 9.46 TP53 HRAS
7 cellular response to gamma radiation GO:0071480 9.43 TP53 HRAS
8 cell aging GO:0007569 9.4 TP53 HRAS
9 regulation of long-term neuronal synaptic plasticity GO:0048169 9.37 KRAS HRAS
10 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.32 TP53 MUC1
11 response to isolation stress GO:0035900 9.26 KRAS HRAS
12 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003 9.16 TP53 MUC1
13 Ras protein signal transduction GO:0007265 9.13 TP53 KRAS HRAS
14 stimulatory C-type lectin receptor signaling pathway GO:0002223 8.92 MUC5AC MUC1 KRAS HRAS

Molecular functions related to Pancreatic Signet Ring Cell Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GDP binding GO:0019003 8.96 KRAS HRAS
2 p53 binding GO:0002039 8.62 TP53 MUC1

Sources for Pancreatic Signet Ring Cell Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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