MCID: PNC006
MIFTS: 28

Pancreatic Somatostatinoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Pancreatic Somatostatinoma

MalaCards integrated aliases for Pancreatic Somatostatinoma:

Name: Pancreatic Somatostatinoma 12 15 17 71
Pancreatic Delta Cell Somatostatin Producing Neoplasm 12
Pancreatic Somatostatin Cell Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4432
NCIt 49 C95595
UMLS 71 C1368041

Summaries for Pancreatic Somatostatinoma

MalaCards based summary : Pancreatic Somatostatinoma, also known as pancreatic delta cell somatostatin producing neoplasm, is related to somatostatinoma and carcinoid syndrome, and has symptoms including diarrhea An important gene associated with Pancreatic Somatostatinoma is SST (Somatostatin), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. Affiliated tissues include Pancreas, testes and brain.

Related Diseases for Pancreatic Somatostatinoma

Diseases related to Pancreatic Somatostatinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 somatostatinoma 31.1 VIP SST PPY NF1 CALCA
2 carcinoid syndrome 30.4 SST CALCA
3 neurofibromatosis, type i 29.6 SST NF1
4 duodenal somatostatinoma 29.3 SST PPY NF1
5 neuroendocrine tumor 29.3 VIP SST NF1 CALCA
6 islet cell tumor 29.3 VIP SST PPY CALCA
7 multiple endocrine neoplasia, type i 28.7 VIP SST PPY NF1
8 cholelithiasis 10.3
9 hypoglycemia 10.3
10 carotid body cancer 10.3 SST CALCA
11 thyroid gland medullary carcinoma 10.2 SST CALCA
12 malignant pheochromocytoma 10.2 SST CALCA
13 pulmonary blastoma 10.2 SST CALCA
14 jejunal somatostatinoma 10.2 SST PPY
15 non-functioning pancreatic endocrine tumor 10.2 SST PPY
16 rectum neuroendocrine neoplasm 10.2 VIP SST
17 duodenal gastrinoma 10.1 SST PPY
18 diarrhea 10.1
19 endocrine gland cancer 10.1
20 rare tumor 10.1
21 gastrinoma 10.1 VIP SST
22 glucagonoma 10.1 VIP SST
23 pancreatic gastrinoma 10.1 SST PPY
24 leprosy 2 10.1 VIP CALCA
25 fibrous dysplasia 10.1 SST CALCA
26 binswanger's disease 10.1 VIP SST
27 gastric ulcer 10.1 SST CALCA
28 cluster headache 10.1 VIP CALCA
29 pancreatic endocrine carcinoma 10.1 SST PPY
30 duodenum disease 10.1 SST PPY
31 colon neuroendocrine neoplasm 10.1 VIP CALCA
32 thyroid carcinoma, familial medullary 10.1 SST CALCA
33 vasomotor rhinitis 10.1 VIP CALCA
34 zollinger-ellison syndrome 10.1 SST PPY
35 cryptosporidiosis 10.1 VIP SST
36 secretory diarrhea 10.1 VIP SST
37 duodenal ulcer 10.1 SST CALCA
38 autonomic nervous system disease 10.0 PPY CALCA
39 ganglioneuroma 10.0 VIP SST
40 short bowel syndrome 10.0 VIP SST
41 ocular motor apraxia 10.0
42 gallbladder disease 1 10.0
43 dermatitis herpetiformis, familial 10.0
44 intestinal pseudo-obstruction 10.0
45 nodal marginal zone lymphoma 10.0
46 goiter 10.0
47 tuberous sclerosis 10.0
48 hyperinsulinism 10.0
49 dermatitis 10.0
50 acinar cell carcinoma 10.0

Graphical network of the top 20 diseases related to Pancreatic Somatostatinoma:



Diseases related to Pancreatic Somatostatinoma

Symptoms & Phenotypes for Pancreatic Somatostatinoma

UMLS symptoms related to Pancreatic Somatostatinoma:


diarrhea

Drugs & Therapeutics for Pancreatic Somatostatinoma

Search Clinical Trials , NIH Clinical Center for Pancreatic Somatostatinoma

Genetic Tests for Pancreatic Somatostatinoma

Anatomical Context for Pancreatic Somatostatinoma

MalaCards organs/tissues related to Pancreatic Somatostatinoma:

40
Pancreas, Testes, Brain
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Pancreatic Somatostatinoma:
# Tissue Anatomical CompartmentCell Relevance
1 Pancreas Islets of Langerhans Delta Cells Affected by disease

Publications for Pancreatic Somatostatinoma

Articles related to Pancreatic Somatostatinoma:

(show all 47)
# Title Authors PMID Year
1
Pancreatic somatostatinoma diagnosed preoperatively: report of a case. 61
24413789 2014
2
Somatostatinoma syndrome: a challenging differential diagnosis among pancreatic tumors. 61
31528595 2013
3
Pancreatic somatostatinoma with obscure inhibitory syndrome and mixed pathological pattern. 61
20043348 2010
4
Cardiac metastasis from malignant pancreatic somatostatinoma. 61
19733881 2010
5
FNAC diagnosis of pancreatic somatostatinoma. 61
21938182 2009
6
Pancreatic somatostatinoma characterized by extreme hypoglycemia. 61
19719976 2009
7
Pancreatic somatostatinoma manifested as severe hypoglycemia. 61
19565056 2009
8
Pancreatic somatostatinoma with von Recklinghausen's disease. 61
18926936 2009
9
Pancreatic somatostatinoma and tuberous sclerosis: case report of an exceedingly rare association. 61
18672238 2009
10
Diagnosis and treatment of pancreatic somatostatinoma: a case report. 61
19080351 2008
11
[Atypical pancreatic somatostatinoma]. 61
17916298 2007
12
[A case of pancreatic somatostatinoma]. 61
17132924 2006
13
Fine-needle aspiration cytology of pancreatic somatostatinoma: the importance of immunohistochemistry for the cytologic diagnosis of pancreatic endocrine neoplasms. 61
16007666 2005
14
Metastatic somatostatinoma of the chest wall. 61
15952320 2005
15
A small, incidentally detected pancreatic somatostatinoma: report of a case. 61
12560911 2003
16
Periampullary pancreatic somatostatinoma. 61
12417508 2002
17
[Von Recklinghausen's disease associated with pancreatic somatostatinoma]. 61
11769067 2001
18
Reciprocal changes in progression of gastric mucosa-associated lymphoid tissue lymphoma and pancreatic somatostatinoma. 61
9870841 1998
19
Calcitonin-producing pancreatic somatostatinoma: report of a case. 61
9872549 1998
20
Somatostatin receptor scintigraphy of malignant somatostatinoma with indium-111-pentetreotide. 61
9189135 1997
21
Pancreatic somatostatinoma presenting with chronic intestinal pseudo-obstruction syndrome. 61
17912215 1996
22
Brain metastasis from malignant pancreatic somatostatinoma. Case report. 61
8814175 1996
23
[A case of pancreatic somatostatinoma]. 61
8992398 1996
24
[Pancreatic somatostatinoma and MEN 1. Apropos of a case. Review of the literature]. 61
8734292 1996
25
[Somatostatinoma in the pancreas]. 61
8066887 1994
26
[Pancreatic somatostatinoma. A new case]. 61
8367432 1993
27
Pancreatic somatostatinoma. 61
2077482 1990
28
Pancreatic somatostatinoma: a case report and review of the literature. 61
1969977 1990
29
Pancreatic somatostatinoma: presentation with recurrent episodes of severe hyperglycaemia and ketoacidosis. 61
2855274 1988
30
[A case of somatostatinoma of the pancreas]. 61
2842967 1988
31
Malignant pancreatic somatostatinoma in a patient with dermatitis herpetiformis and coeliac disease. 61
2899527 1988
32
[Somatostatinomas]. 61
2899036 1988
33
[A case of pancreatic somatostatinoma associated with carcinoid syndrome]. 61
2824888 1987
34
[The secretin test in a case of pancreatic somatostatinoma]. 61
3006014 1986
35
Somatostatinoma of the pancreas. 61
2867661 1985
36
A case of duodenal somatostatinoma: diagnostic usefulness of calcium--pentagastrin test. 61
6137434 1983
37
Pancreatic somatostatinoma. 61
6314830 1983
38
Pancreatic somatostatinoma. 61
6314831 1983
39
Pancreatic somatostatinoma: abundance of somatostatin-28(1-12)-like immunoreactivity in tumor and plasma. 61
6137494 1983
40
Human somatostatin I: sequence of the cDNA. 61
6126875 1982
41
Characterization of somatostatin-like components in the tumors and plasma of a patient with a somatostatinoma. 61
6108968 1981
42
Pancreatic somatostatinoma presenting with hypoglycaemia. 61
6105026 1980
43
Molecular forms of somatostatin in normal subjects and in patients with pancreatic somatostatinoma. 61
6105027 1980
44
Calcitonin-producing pancreatic somatostatinoma. 61
6102950 1980
45
Pancreatic somatostatinoma: histologic, clinical, and angiographic features. 61
227259 1979
46
Calcitonin secretion by a pancreatic somatostatinoma. 61
714084 1978
47
Pancreatic somatostatinoma. Clinical features and physiological implications. 61
66472 1977

Variations for Pancreatic Somatostatinoma

Expression for Pancreatic Somatostatinoma

Search GEO for disease gene expression data for Pancreatic Somatostatinoma.

Pathways for Pancreatic Somatostatinoma

GO Terms for Pancreatic Somatostatinoma

Biological processes related to Pancreatic Somatostatinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.43 VIP TAAR8 TAAR5 TAAR2 PPY NF1
2 positive regulation of endothelial cell proliferation GO:0001938 9.4 VIP NF1
3 response to heat GO:0009408 9.37 SST CALCA
4 feeding behavior GO:0007631 9.32 PPY CALCA
5 negative regulation of osteoclast differentiation GO:0045671 9.26 NF1 CALCA
6 G protein-coupled receptor signaling pathway GO:0007186 9.17 VIP TAAR8 TAAR5 TAAR2 SST PPY
7 positive regulation of blood vessel diameter GO:0097755 9.16 VIP CALCA

Molecular functions related to Pancreatic Somatostatinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.26 VIP SST PPY CALCA
2 neuropeptide hormone activity GO:0005184 9.16 VIP PPY
3 trace-amine receptor activity GO:0001594 8.8 TAAR8 TAAR5 TAAR2

Sources for Pancreatic Somatostatinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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