MCID: PNC028
MIFTS: 27

Pancreatic Steatorrhea

Categories: Endocrine diseases, Gastrointestinal diseases

Aliases & Classifications for Pancreatic Steatorrhea

MalaCards integrated aliases for Pancreatic Steatorrhea:

Name: Pancreatic Steatorrhea 12 15 71
Pancreatic Steatorrhoea 12 32

Classifications:



External Ids:

Disease Ontology 12 DOID:10610
ICD9CM 34 579.4
SNOMED-CT 67 54576000
ICD10 32 K90.3
UMLS 71 C0152166

Summaries for Pancreatic Steatorrhea

MalaCards based summary : Pancreatic Steatorrhea, also known as pancreatic steatorrhoea, is related to duodenal ulcer and exocrine pancreatic insufficiency. An important gene associated with Pancreatic Steatorrhea is PNLIP (Pancreatic Lipase), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and Pancreatic secretion. Affiliated tissues include testes and pancreas, and related phenotype is Strongly decreased NFAT1-GFP nuclear translocation.

Related Diseases for Pancreatic Steatorrhea

Diseases related to Pancreatic Steatorrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
# Related Disease Score Top Affiliating Genes
1 duodenal ulcer 29.2 SCT CCK
2 exocrine pancreatic insufficiency 28.3 SCT PNLIP CELA3B CELA1 CCK
3 pancreatitis 28.0 SCT PRSS1 PNLIP CELA3B CCK
4 pancreatic lipase deficiency 10.5
5 cystic fibrosis 10.4
6 ileitis 10.0
7 mycobacterium tuberculosis 1 10.0
8 diarrhea 10.0
9 pulmonary tuberculosis 10.0
10 lung disease 10.0
11 pancreatic agenesis 1 10.0 SCT PNLIP
12 recurrent acute pancreatitis 9.9 SCT PRSS1
13 duodenogastric reflux 9.6 SCT CCK
14 dumping syndrome 9.6 SCT CCK
15 nutritional deficiency disease 9.5 SCT CCK
16 bile acid malabsorption, primary 9.4 SCT PNLIP CCK
17 alcoholic pancreatitis 9.3 SCT PRSS1 CCK
18 neuroendocrine tumor 9.2 SCT CCK
19 pancreatic adenocarcinoma 9.0 SCT PRSS1 CCK
20 biliary dyskinesia 9.0 SCT PRSS1 CELA1 CCK
21 acute pancreatitis 9.0 SCT PRSS1 PNLIP CCK
22 celiac disease 1 8.9 SCT CELA3B CELA1 CCK

Comorbidity relations with Pancreatic Steatorrhea via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Pancreatic Steatorrhea:



Diseases related to Pancreatic Steatorrhea

Symptoms & Phenotypes for Pancreatic Steatorrhea

GenomeRNAi Phenotypes related to Pancreatic Steatorrhea according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Strongly decreased NFAT1-GFP nuclear translocation GR00359-A 8.92 CCK CLPS PNLIP PRSS1

Drugs & Therapeutics for Pancreatic Steatorrhea

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Investigation of the Association Between Helicobacter Pylori Infection and Abdominal Pain in Cystic Fibrosis Patients Withdrawn NCT00765401

Search NIH Clinical Center for Pancreatic Steatorrhea

Genetic Tests for Pancreatic Steatorrhea

Anatomical Context for Pancreatic Steatorrhea

MalaCards organs/tissues related to Pancreatic Steatorrhea:

40
Testes, Pancreas

Publications for Pancreatic Steatorrhea

Articles related to Pancreatic Steatorrhea:

(show top 50) (show all 82)
# Title Authors PMID Year
1
An update on pancreatic pathophysiology (do we have to rewrite pancreatic pathophysiology?). 61
24468827 2014
2
Chronic pancreatitis. 61
22782018 2012
3
Chronic pancreatitis. 61
20693896 2010
4
Pancreatic exocrine insufficiency: diagnostic evaluation and replacement therapy with pancreatic enzymes. 61
20814209 2010
5
Low fecal elastase 1 levels do not indicate exocrine pancreatic insufficiency in type-1 diabetes mellitus. 61
18362841 2008
6
The commercially available ELISA for pancreatic elastase 1 based on polyclonal antibodies does measure an as yet unknown antigen different from purified elastase 1. Binding studies and clinical use in patients with exocrine pancreatic insufficiency. 61
13130326 2003
7
Quantitative determination of faecal fatty acids and triglycerides by Fourier transform infrared analysis with a sodium chloride transmission flow cell. 61
12392307 2002
8
Are minimicrosphere pancrelipase capsules effective enough for the treatment of pancreatic steatorrhea? 61
11374718 2001
9
[Study on pancreatic steatorrhea in patients with chronic pancreatitis]. 61
11215184 2000
10
Chronic pancreatitis. 61
17031112 2000
11
Effect of bacterial or porcine lipase with low- or high-fat diets on nutrient absorption in pancreatic-insufficient dogs. 61
9922325 1999
12
Near-infrared spectrometry analysis of fat, neutral sterols, bile acids, and short-chain fatty acids in the feces of patients with pancreatic maldigestion and malabsorption. 61
9629511 1998
13
Pancreatic dysfunction and treatment options. 61
9548675 1998
14
Determination of fecal fat concentration by near infrared spectrometry for the screening of pancreatic steatorrhea. 61
9520087 1998
15
Can pancreatic steatorrhea be diagnosed without chemical analysis? 61
9387033 1997
16
Bacterial lipase and high-fat diets in canine exocrine pancreatic insufficiency: a new therapy of steatorrhea? 61
9178698 1997
17
Pancreatic steatorrhea, malabsorption, and nutrition biochemistry: a comparison of Japanese, European, and American patients with chronic pancreatitis. 61
9163777 1997
18
[Treatment of pancreatic insufficiency with a preparation containing high lipase activity]. 61
9157336 1997
19
Monitoring pancreatin supplementation in cystic fibrosis patients with the 13C-Hiolein breath test: evidence for normalized fat assimilation with high dose pancreatin therapy. 61
9066102 1997
20
Exocrine pancreatic insufficiency: accuracy and clinical value of the uniformly labelled 13C-Hiolein breath test. 61
9026480 1996
21
Small bowel intussusception and brown bowel syndrome in association with severe malnutrition. 61
8678014 1996
22
The prevalence of occult gastrointestinal bleeding in celiac sprue. 61
8602182 1996
23
Medium-chain triglyceride absorption in patients with pancreatic insufficiency. 61
8927947 1996
24
Faecal triglycerides and fatty acids in the differential diagnosis of pancreatic insufficiency and intestinal malabsorption in patients with low fat intakes. 61
7774758 1995
25
Effects of pancreatic digestive enzymes, sodium bicarbonate, and a proton pump inhibitor on steatorrhoea caused by pancreatic diseases. 61
7774757 1995
26
Lipolytic activity of bacterial lipase survives better than that of porcine lipase in human gastric and duodenal content. 61
8020666 1994
27
New enteric-coated high-lipase pancreatic extract in the treatment of pancreatic steatorrhea. 61
8113582 1994
28
Fate of oral enzymes in pancreatic insufficiency. 61
8504976 1993
29
Enzyme treatment of exocrine pancreatic insufficiency in chronic pancreatitis. 61
8224569 1993
30
Therapeutic potential and clinical efficacy of acid-resistant fungal lipase in the treatment of pancreatic steatorrhoea due to cystic fibrosis. 61
1594552 1992
31
Increased intragastric acid-resistant lipase activity and lipolysis in pancreatic steatorrhoea due to cystic fibrosis. 61
1594551 1992
32
Short report: lipid and vitamin B12 malassimilation in pancreatic insufficiency. 61
1888821 1991
33
Determination of faecal chymotrypsin concentration and 72-hour faecal chymotrypsin output in the detection of pancreatic steatorrhoea. 61
1775936 1991
34
Pancreatic insufficiency. Duodenal and jejunal pH, bile acid activity, and micellar lipid solubilization. 61
2212745 1990
35
[Requirements for successful pancreatic enzyme replacement therapy (comparative study of Kreon and Panpur)]. 61
2304764 1990
36
Acid resistant lipase as replacement therapy in chronic pancreatic exocrine insufficiency: a study in dogs. 61
2759481 1989
37
Fecal fat concentration in the differential diagnosis of steatorrhea. 61
2912027 1989
38
Detection of pancreatic steatorrhea by oral pancreatic function tests. 61
3262493 1988
39
Evaluation of a tubeless pancreatic function test in patients with steatorrhoea in a district general hospital. 61
3290481 1988
40
Serum cathodic trypsin-like immunoreactivity, pancreatic lipase, and pancreatic isoamylase as diagnostic tests of chronic pancreatitis or pancreatic steatorrhea. 61
3291084 1988
41
Replacement therapy in pancreatic insufficiency with a new pancreatin preparation respecting the physiological ratio of lipase/trypsin activity. 61
3371850 1988
42
Pancreatic steatorrhea and pulmonary tuberculosis. 61
3361162 1988
43
Fecal fat concentrations and pancreatic steatorrhea. 61
3337054 1988
44
Review: pancreatic enzyme replacement--applied physiology and pharmacology. 61
2979686 1987
45
Raised fecal fat concentration is not a valid indicator of pancreatic steatorrhea. 61
3646827 1987
46
Serum immunoreactive cationic trypsinogen: a useful indicator of severe exocrine dysfunction in the paediatric patient without cystic fibrosis. 61
3792918 1986
47
Utility of fecal fat concentrations as screening test in pancreatic insufficiency. 61
3757718 1986
48
Effect of cimetidine in pancreatic steatorrhoea. 61
18668874 1986
49
Biochemical vitamin E deficiency in chronic pancreatitis. 61
3693979 1986
50
Pancreatic steatorrhea: action of a total lyophilized pancreas preparation: an "in vitro" and "in vivo" study. 61
3435264 1986

Variations for Pancreatic Steatorrhea

Expression for Pancreatic Steatorrhea

Search GEO for disease gene expression data for Pancreatic Steatorrhea.

Pathways for Pancreatic Steatorrhea

GO Terms for Pancreatic Steatorrhea

Cellular components related to Pancreatic Steatorrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 SCT PRSS1 PNLIP CLPS CELA1 CCK
2 extracellular space GO:0005615 9.1 SCT PRSS1 PNLIP CELA3B CELA1 CCK

Biological processes related to Pancreatic Steatorrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.5 PRSS1 CELA3B CELA1
2 lipid catabolic process GO:0016042 9.26 PNLIP CLPS
3 retinoid metabolic process GO:0001523 9.16 PNLIP CLPS
4 lipid digestion GO:0044241 8.96 PNLIP CLPS
5 digestion GO:0007586 8.8 PRSS1 CLPS CCK

Molecular functions related to Pancreatic Steatorrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.62 PRSS1 PNLIP CELA3B CELA1
2 peptidase activity GO:0008233 9.33 PRSS1 CELA3B CELA1
3 hormone activity GO:0005179 9.26 SCT CCK
4 serine-type endopeptidase activity GO:0004252 9.13 PRSS1 CELA3B CELA1
5 serine-type peptidase activity GO:0008236 8.8 PRSS1 CELA3B CELA1

Sources for Pancreatic Steatorrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....