MCID: PNC028
MIFTS: 31

Pancreatic Steatorrhea

Categories: Endocrine diseases, Gastrointestinal diseases

Aliases & Classifications for Pancreatic Steatorrhea

MalaCards integrated aliases for Pancreatic Steatorrhea:

Name: Pancreatic Steatorrhea 12 15 74
Pancreatic Steatorrhoea 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10610
ICD9CM 36 579.4
SNOMED-CT 69 54576000
ICD10 34 K90.3
UMLS 74 C0152166

Summaries for Pancreatic Steatorrhea

MalaCards based summary : Pancreatic Steatorrhea, also known as pancreatic steatorrhoea, is related to steatorrhea and pancreatitis. An important gene associated with Pancreatic Steatorrhea is GFPT2 (Glutamine-Fructose-6-Phosphate Transaminase 2), and among its related pathways/superpathways are Pancreatic secretion and Alanine, aspartate and glutamate metabolism. Affiliated tissues include pancreas, testes and skin.

Related Diseases for Pancreatic Steatorrhea

Diseases related to Pancreatic Steatorrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 steatorrhea 30.8 CCK CELA1 PNLIP SCT
2 pancreatitis 30.1 CCK CTSB PNLIP PRSS1 SCT
3 sulfonamide allergy 10.4 GFPT1 GFPT2
4 angular cheilitis 10.4 GFPT1 GFPT2
5 pancreatic agenesis 1 10.4 PNLIP SCT
6 lipodystrophy, familial partial, type 2 10.4 GFPT1 GFPT2
7 pancreatic lipase deficiency 10.4
8 recurrent acute pancreatitis 10.4 PRSS1 SCT
9 biliary dyskinesia 10.4 CCK SCT
10 duodenogastric reflux 10.3 CCK SCT
11 pancreatic cholera 10.3 CCK SCT
12 fungal esophagitis 10.3 ATP12A ATP4A
13 diclofenac allergy 10.3 ATP12A ATP4A
14 neonatal candidiasis 10.3 ATP12A ATP4A
15 photoallergic dermatitis 10.3 ATP12A ATP4A
16 cystic fibrosis 10.3
17 squamous papillomatosis 10.3 ATP12A ATP4A
18 toxic megacolon 10.3 ATP12A ATP4A
19 duodenal gastrinoma 10.3 CCK SCT
20 aspiration pneumonitis 10.3 ATP12A ATP4A
21 gastric antral vascular ectasia 10.3 ATP12A ATP4A
22 esophageal candidiasis 10.3 ATP12A ATP4A
23 acute laryngitis 10.3 ATP12A ATP4A
24 laryngitis 10.3 ATP12A ATP4A
25 duodenitis 10.3 ATP12A ATP4A
26 rumination disorder 10.3 ATP12A ATP4A
27 active peptic ulcer disease 10.3 ATP12A ATP4A
28 congenital disorder of deglycosylation 10.3 ATP12A ATP4A
29 bladder calculus 10.3 ATP12A ATP4A
30 ischemic neuropathy 10.3 ATP12A ATP4A
31 capillary disease 10.2 ATP12A ATP4A
32 peptic esophagitis 10.2 ATP12A ATP4A
33 dyskinesia of esophagus 10.2 ATP12A ATP4A
34 hernia, hiatus 10.2 ATP12A ATP4A
35 postsurgical hypothyroidism 10.2 ATP12A ATP4A
36 lymphocytic colitis 10.2 ATP12A ATP4A
37 esophageal atresia/tracheoesophageal fistula 10.2 ATP12A ATP4A
38 clostridium difficile colitis 10.2 ATP12A ATP4A
39 tropical calcific pancreatitis 10.2 CTSB PRSS1
40 diarrhea 1, secretory chloride, congenital 10.2 ATP12A ATP4A
41 esophagitis, eosinophilic, 1 10.2 ATP12A ATP4A
42 microscopic colitis 10.2 ATP12A ATP4A
43 laryngeal tuberculosis 10.2 ATP12A ATP4A
44 exocrine pancreatic insufficiency 10.2 CCK PNLIP SCT
45 chronic laryngitis 10.2 ATP12A ATP4A
46 eosinophilic gastritis 10.2 ATP12A ATP4A
47 esophagus adenocarcinoma 10.2 ATP12A ATP4A
48 diphyllobothriasis 10.2 CBLIF SCT
49 chronic intestinal vascular insufficiency 10.2 ATP12A ATP4A
50 polyposis, skin pigmentation, alopecia, and fingernail changes 10.2 ATP12A ATP4A

Comorbidity relations with Pancreatic Steatorrhea via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Pancreatic Steatorrhea:



Diseases related to Pancreatic Steatorrhea

Symptoms & Phenotypes for Pancreatic Steatorrhea

Drugs & Therapeutics for Pancreatic Steatorrhea

Search Clinical Trials , NIH Clinical Center for Pancreatic Steatorrhea

Genetic Tests for Pancreatic Steatorrhea

Anatomical Context for Pancreatic Steatorrhea

MalaCards organs/tissues related to Pancreatic Steatorrhea:

42
Pancreas, Testes, Skin

Publications for Pancreatic Steatorrhea

Articles related to Pancreatic Steatorrhea:

(show all 29)
# Title Authors Year
1
Are minimicrosphere pancrelipase capsules effective enough for the treatment of pancreatic steatorrhea? ( 11374718 )
2001
2
Determination of fecal fat concentration by near infrared spectrometry for the screening of pancreatic steatorrhea. ( 9520087 )
1998
3
Pancreatic steatorrhea, malabsorption, and nutrition biochemistry: a comparison of Japanese, European, and American patients with chronic pancreatitis. ( 9163777 )
1997
4
Can pancreatic steatorrhea be diagnosed without chemical analysis? ( 9387033 )
1997
5
New enteric-coated high-lipase pancreatic extract in the treatment of pancreatic steatorrhea. ( 8113582 )
1994
6
Increased intragastric acid-resistant lipase activity and lipolysis in pancreatic steatorrhoea due to cystic fibrosis. ( 1594551 )
1992
7
Therapeutic potential and clinical efficacy of acid-resistant fungal lipase in the treatment of pancreatic steatorrhoea due to cystic fibrosis. ( 1594552 )
1992
8
Determination of faecal chymotrypsin concentration and 72-hour faecal chymotrypsin output in the detection of pancreatic steatorrhoea. ( 1775936 )
1991
9
Detection of pancreatic steatorrhea by oral pancreatic function tests. ( 3262493 )
1988
10
Serum cathodic trypsin-like immunoreactivity, pancreatic lipase, and pancreatic isoamylase as diagnostic tests of chronic pancreatitis or pancreatic steatorrhea. ( 3291084 )
1988
11
Fecal fat concentrations and pancreatic steatorrhea. ( 3337054 )
1988
12
Pancreatic steatorrhea and pulmonary tuberculosis. ( 3361162 )
1988
13
Raised fecal fat concentration is not a valid indicator of pancreatic steatorrhea. ( 3646827 )
1987
14
Pancreatic steatorrhea: action of a total lyophilized pancreas preparation: an "in vitro" and "in vivo" study. ( 3435264 )
1986
15
Effect of cimetidine in pancreatic steatorrhoea. ( 18668874 )
1986
16
Effect of cimetidine on enzyme inactivation, bile acid precipitation, and lipid solubilisation in pancreatic steatorrhoea due to cystic fibrosis. ( 3849459 )
1985
17
Effect of intrajejunal acidity on aqueous phase bile acid and lipid concentrations in pancreatic steatorrhoea due to cystic fibrosis. ( 6714794 )
1984
18
Pancreatic Society of Great Britain and Ireland: Annual Meeting, 1980: Role of pH-dependent bile acid precipitation in fat maldigestion due to pancreatic steatorrhoea. Preliminary communication. ( 19310778 )
1982
19
Decrease in pancreatic steatorrhoea by positioned-release enzyme capsules. ( 6814569 )
1982
20
Double-blind cross-over trial of an enzyme preparation in pancreatic steatorrhoea. ( 6912244 )
1981
21
Small bowel structure and function in pancreatic steatorrhea. ( 1082072 )
1975
22
Increase in urinary indican excretion in pancreatic steatorrhoea following replacement therapy. ( 1153945 )
1975
23
Pancreatic scanning in the assessment of pancreatic function: experiences with 14 cases of pancreatic steatorrhoea. ( 4568024 )
1972
24
Pancreatic steatorrhea. ( 5681601 )
1968
25
A case of pancreatic steatorrhoea. ( 6043129 )
1967
26
Maintenance therapy of pancreatic steatorrhoea with concentrated pancreatic extract. ( 5323324 )
1965
27
PANCREATIC REPLACEMENT THERAPY IN THE TREATMENT OF PANCREATIC STEATORRHOEA. ( 14058262 )
1963
28
Thyroxine metabolism in untreated and treated pancreatic steatorrhea. ( 13907777 )
1962
29
Chronic relapsing pancreatitis apparently initiated by trauma: report of a case with eventual development of pancreatic calcification, diabetes mellitus, pancreatic steatorrhea, and duodenal ulcer with hematemesis and melena. ( 13826234 )
1959

Variations for Pancreatic Steatorrhea

Expression for Pancreatic Steatorrhea

Search GEO for disease gene expression data for Pancreatic Steatorrhea.

Pathways for Pancreatic Steatorrhea

Pathways related to Pancreatic Steatorrhea according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.12 CELA3B PNLIP PRSS1
2 10.88 GFPT1 GFPT2
3 10.64 CBLIF PNLIP
4 10.48 CBLIF PRSS1
5 9.64 CBLIF CCK SCT

GO Terms for Pancreatic Steatorrhea

Cellular components related to Pancreatic Steatorrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CBLIF CCK CELA1 CTSB GHRL PNLIP
2 extracellular space GO:0005615 9.36 ATP4A CBLIF CCK CELA1 CELA3B CTSB

Biological processes related to Pancreatic Steatorrhea according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 potassium ion import across plasma membrane GO:1990573 9.57 ATP12A ATP4A
2 protein N-linked glycosylation GO:0006487 9.56 GFPT1 GFPT2
3 digestion GO:0007586 9.55 CCK PRSS1
4 ATP hydrolysis coupled proton transport GO:0015991 9.54 ATP12A ATP4A
5 decidualization GO:0046697 9.52 CTSB GHRL
6 glutamine metabolic process GO:0006541 9.51 GFPT1 GFPT2
7 cobalamin metabolic process GO:0009235 9.49 CBLIF PRSS1
8 cellular sodium ion homeostasis GO:0006883 9.48 ATP12A ATP4A
9 energy reserve metabolic process GO:0006112 9.46 GFPT1 GFPT2
10 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.43 ATP12A ATP4A
11 cellular potassium ion homeostasis GO:0030007 9.4 ATP12A ATP4A
12 sodium ion export across plasma membrane GO:0036376 9.37 ATP12A ATP4A
13 UDP-N-acetylglucosamine biosynthetic process GO:0006048 9.32 GFPT1 GFPT2
14 fructose 6-phosphate metabolic process GO:0006002 9.26 GFPT1 GFPT2
15 UDP-N-acetylglucosamine metabolic process GO:0006047 9.16 GFPT1 GFPT2
16 carbohydrate derivative metabolic process GO:1901135 8.96 GFPT1 GFPT2
17 carbohydrate derivative biosynthetic process GO:1901137 8.62 GFPT1 GFPT2

Molecular functions related to Pancreatic Steatorrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.87 ATP12A ATP4A CELA1 CELA3B CTSB PNLIP
2 peptidase activity GO:0008233 9.78 CELA1 CELA3B CTSB PRSS1
3 serine-type peptidase activity GO:0008236 9.61 CELA1 CELA3B PRSS1
4 hormone activity GO:0005179 9.58 CCK GHRL SCT
5 transaminase activity GO:0008483 9.46 GFPT1 GFPT2
6 serine-type endopeptidase activity GO:0004252 9.43 CELA1 CELA3B PRSS1
7 sodium:potassium-exchanging ATPase activity GO:0005391 9.37 ATP12A ATP4A
8 carbohydrate derivative binding GO:0097367 9.16 GFPT1 GFPT2
9 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP12A ATP4A
10 glutamine-fructose-6-phosphate transaminase (isomerizing) activity GO:0004360 8.62 GFPT1 GFPT2

Sources for Pancreatic Steatorrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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