Pancreatitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PNC044 MIFTS: 61	Pancreatitis Categories: Bone diseases, Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Pancreatitis

MalaCards integrated aliases for Pancreatitis:

Name: Pancreatitis ¹² ²⁴ ²⁹ ⁵⁴ ⁶ ⁴² ¹⁵ ³⁹ ¹⁷ ⁷¹

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases Cancer diseases
Anatomical: Endocrine diseases Gastrointestinal diseases Bone diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the digestive system

Disorders of gallbladder, biliary tract and pancreas

Acute pancreatitis

Acute pancreatitis, unspecified

External Ids:

Disease Ontology ¹² DOID:4989

MeSH ⁴³ D010195

NCIt ⁴⁹ C3306

SNOMED-CT ⁶⁷ 75694006

ICD10 ³² K85.9

EFO ¹⁷ EFO_0000278

UMLS ⁷¹ C0030305

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Summaries for Pancreatitis

MedlinePlus : ⁴² The pancreas is a large gland behind the stomach and close to the first part of the small intestine. It secretes digestive juices into the small intestine through a tube called the pancreatic duct. The pancreas also releases the hormones insulin and glucagon into the bloodstream. Pancreatitis is inflammation of the pancreas. It happens when digestive enzymes start digesting the pancreas itself. Pancreatitis can be acute or chronic. Either form is serious and can lead to complications. Acute pancreatitis occurs suddenly and usually goes away in a few days with treatment. It is often caused by gallstones. Common symptoms are severe pain in the upper abdomen, nausea, and vomiting. Treatment is usually a few days in the hospital for intravenous (IV) fluids, antibiotics, and medicines to relieve pain. Chronic pancreatitis does not heal or improve. It gets worse over time and leads to permanent damage. The most common cause is heavy alcohol use. Other causes include cystic fibrosis and other inherited disorders, high levels of calcium or fats in the blood, some medicines, and autoimmune conditions. Symptoms include nausea, vomiting, weight loss, and oily stools. Treatment may also be a few days in the hospital for intravenous (IV) fluids, medicines to relieve pain, and nutritional support. After that, you may need to start taking enzymes and eat a special diet. It is also important to not smoke or drink alcohol. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Pancreatitis is related to pancreatitis, hereditary and tropical calcific pancreatitis, and has symptoms including nausea and vomiting, abdominal pain and constipation. An important gene associated with Pancreatitis is TMEM67 (Transmembrane Protein 67), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and Pancreatic secretion. The drugs Somatostatin and Cefoperazone have been mentioned in the context of this disorder. Affiliated tissues include pancreas, testes and liver, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : ⁷⁴ Pancreatitis is a condition characterized by inflammation of the pancreas. The pancreas is a large organ... more...

GeneReviews: NBK190101

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Related Diseases for Pancreatitis

Diseases in the Pancreatitis family:

Pancreatitis, Hereditary	Autoimmune Pancreatitis
Acute Pancreatitis	Prss1-Related Hereditary Pancreatitis
Autoimmune Pancreatitis Type 2	Autoimmune Pancreatitis Type 1

Diseases related to Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2451)

#	Related Disease	Score	Top Affiliating Genes
1	pancreatitis, hereditary	35.0	SPINK1 PRSS2 PRSS1 CTRC CPA1 CFTR
2	tropical calcific pancreatitis	34.9	SPINK1 REG1A PRSS2 PRSS1 CTRC
3	pancreatic agenesis 1	34.8	SPINK1 SCT PNLIP CFTR
4	pancreatic cancer	34.7	SST SPINK1 SCT REG3A REG1A PRSS1
5	pancreatic cholera	34.5	SST SCT
6	exocrine pancreatic insufficiency	34.4	SPINK1 SCT PRSS1 PNLIP CFTR CCK
7	pancreatic steatorrhea	34.4	SCT PRSS1 PNLIP CCK
8	pancreatic gastrinoma	34.2	SST SCT
9	glucagonoma	34.1	SST SCT
10	prss1-related hereditary pancreatitis	34.0	SPINK1 PRSS2 PRSS1 CTRC CFTR
11	acute pancreatitis	33.8	VMP1 SST SPINK1 SCT REG3A PRSS1
12	alcoholic pancreatitis	33.8	SPINK1 SCT REG3A PRSS1 LPL CPB1
13	pancreas, annular	33.3	SPINK1 SCT PRSS1
14	familial lipoprotein lipase deficiency	33.2	PNLIP LPL APOC2
15	enterokinase deficiency	33.1	SCT CCK
16	hyperlipoproteinemia, type i	32.9	PNLIP LPL APOC2
17	neuroendocrine tumor	32.7	SST SCT CCK
18	cholecystolithiasis	32.7	SST CCK
19	apolipoprotein c-ii deficiency	32.7	LPL APOC2
20	biliary dyskinesia	32.6	SST SPINK1 SCT REG3A PRSS1 CFTR
21	bile acid malabsorption, primary	32.6	SST SCT PNLIP CFTR CCK
22	multiple endocrine neoplasia, type i	32.6	SST SCT CASR
23	maturity-onset diabetes of the young	32.5	SST REG1A LPL APOC2
24	lipase deficiency, combined	32.3	PNLIP LPL
25	diabetes mellitus, noninsulin-dependent	32.1	SST SCT REG1A PNLIP PLA2G2A LPL
26	duodenal obstruction	31.8	SPINK1 PRSS1
27	duodenal ulcer	31.6	SST SCT CCK
28	ileus	31.6	SST CFTR CCK
29	diarrhea	31.6	SST SCT CFTR CCK
30	gastrinoma	31.5	SST SCT CASR
31	endocrine pancreas disease	31.2	SST SCT
32	diabetes mellitus	31.2	SST SPINK1 SCT REG1A PNLIP LPL
33	gallbladder disease	31.0	SST CFTR CCK
34	bile reflux	30.9	SCT CCK
35	duodenogastric reflux	30.7	SST SCT CCK
36	dumping syndrome	30.6	SST SCT CCK
37	duodenal gastrinoma	30.5	SST SCT
38	familial hyperlipidemia	30.4	PNLIP LPL APOC2
39	linitis plastica	30.2	PRSS2 PRSS1
40	cystic kidney disease	30.0	TMEM67 SST SCT CFTR
41	polycystic kidney disease 4 with or without polycystic liver disease	29.8	TMEM67 SST CFTR
42	polycystic liver disease	29.7	TMEM67 SST SCT CFTR
43	hyperlipoproteinemia, type v	29.6	LPL APOC2
44	pancreatic lipase deficiency	12.7
45	pancreatic ductal adenocarcinoma	12.7
46	autoimmune pancreatitis	12.7
47	pancreatic ductal carcinoma	12.6
48	melanoma-pancreatic cancer syndrome	12.6
49	neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset	12.6
50	pancreatic adenocarcinoma	12.6

Graphical network of the top 20 diseases related to Pancreatitis:

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Symptoms & Phenotypes for Pancreatitis

UMLS symptoms related to Pancreatitis:

nausea and vomiting, abdominal pain, constipation, diarrhea, icterus, dyspepsia, heartburn, gastrointestinal gas

GenomeRNAi Phenotypes related to Pancreatitis according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00240-S-1	9.23	SST
2	Decreased viability	GR00249-S	9.23	CPB1 PRSS1
3	Decreased viability	GR00381-A-1	9.23	SCT
4	Decreased viability	GR00386-A-1	9.23	CCK LPL
5	Decreased viability	GR00402-S-2	9.23	CTRC SCT

MGI Mouse Phenotypes related to Pancreatitis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.56	CASR CFTR CTRC PNLIP SPINK1 SST
2	homeostasis/metabolism	MP:0005376	9.44	APOC2 CASR CCK CFTR LPL PNLIP

Sources

Drugs & Therapeutics for Pancreatitis

Drugs for Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 495)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Somatostatin

Approved, Investigational

Phase 4

38916-34-6, 51110-01-1

53481605

Cefoperazone

Approved, Investigational

Phase 4

62893-19-0

44185

Metronidazole

Approved

Phase 4

443-48-1

4173

Pinaverium

Approved

Phase 4

59995-65-2

Lorazepam

Approved

Phase 4

846-49-1

3958

Acetylcholine

Approved, Investigational

Phase 4

51-84-3

187

Valproic acid

Approved, Investigational

Phase 4

99-66-1

3121

Dopamine

Approved

Phase 4

51-61-6, 62-31-7

681

Meropenem

Approved, Investigational

Phase 4

96036-03-2, 119478-56-7

441130 64778

Cilastatin

Approved, Investigational

Phase 4

82009-34-5

5280454 6435415

Imipenem

Approved

Phase 4

74431-23-5, 64221-86-9

104838

Midazolam

Approved, Illicit

Phase 4

59467-70-8

4192

Tocopherol

Approved, Investigational

Phase 4

1406-66-2, 54-28-4

14986

Secretin

Approved

Phase 4

108153-74-8

Erythromycin

Approved, Investigational, Vet_approved

Phase 4

114-07-8

12560 441411

Lidocaine

Approved, Vet_approved

Phase 4

137-58-6

3676

Neostigmine

Approved, Vet_approved

Phase 4

59-99-4

4456

Ceftazidime

Approved

Phase 4

72558-82-8, 78439-06-2

5481173

Morphine

Approved, Investigational

Phase 4

57-27-2

5288826

Dexmedetomidine

Approved, Vet_approved

Phase 4

113775-47-6

5311068 68602

Atropine

Approved, Vet_approved

Phase 4

51-55-8, 5908-99-6

174174

Exenatide

Approved, Investigational

Phase 4

141758-74-9

15991534

Liraglutide

Approved

Phase 4

204656-20-2

44147092

Glucagon

Approved

Phase 4

16941-32-5

Ursodeoxycholic acid

Approved, Investigational

Phase 4

128-13-2

31401

Thrombin

Approved, Investigational

Phase 4

Ritonavir

Approved, Investigational

Phase 4

155213-67-5

392622

Leflunomide

Approved, Investigational

Phase 4

75706-12-6

3899

Meperidine

Approved

Phase 4

57-42-1

4058

Etomidate

Approved

Phase 4

33125-97-2

36339 667484

Anidulafungin

Approved, Investigational

Phase 4

166663-25-8

166548

Glycolic acid

Approved, Investigational

Phase 4

79-14-1

757

Lopinavir

Approved

Phase 4

192725-17-0

92727

Emtricitabine

Approved, Investigational

Phase 4

143491-57-0

60877

Darunavir

Approved

Phase 4

206361-99-1, 635728-49-3

213039

Hydrotalcite

Approved, Experimental, Investigational

Phase 4

12304-65-3

Sucralfate

Approved

Phase 4

54182-58-0

Guaifenesin

Approved, Investigational, Vet_approved

Phase 4

93-14-1

3516

Estradiol

Approved, Investigational, Vet_approved

Phase 4

50-28-2

5757

Spironolactone

Approved

Phase 4

52-01-7, 1952-01-7

5833

Polyestradiol phosphate

Approved

Phase 4

28014-46-2

Bezafibrate

Approved, Investigational

Phase 4

41859-67-0

39042

Glycerol

Approved, Investigational

Phase 4

56-81-5

753

Aprepitant

Approved, Investigational

Phase 4

170729-80-3

6918365 151165

Acetylcysteine

Approved, Investigational

Phase 4

616-91-1

12035

Protein C

Approved

Phase 4

Etanercept

Approved, Investigational

Phase 4

185243-69-0

Ceftriaxone

Approved

Phase 4

73384-59-5

5361919 5479530

Levofloxacin

Approved, Investigational

Phase 4

100986-85-4

149096

Ofloxacin

Approved

Phase 4

82419-36-1

4583

Interventional clinical trials:

(show top 50) (show all 821)

#	Name	Status	NCT ID	Phase	Drugs
1	Epinephrine Sprayed on the Papilla for the Prevention of Post-ERCP Pancreatitis	Unknown status	NCT02839356	Phase 4	epinephrine;normal saline
2	Comparative Study About the Impact of Two Oil Emulsions, One of Them Formulated With MCT, LCT, Olive Oil and Omega 3 Fatty Acids Versus Another One Formulated With MCT and LCT, Administered Intravenously on Severe Acute Pancreatitis Clinical Evolution	Unknown status	NCT01376817	Phase 4	Fat emulsion with MCT, LCT, olive oil and omega 3 fatty acids;Fat emulsion with MCT and LCT
3	Dexmedetomidine Hydrochloride in the Prevention of Organ Failure Following	Unknown status	NCT02691598	Phase 4	Infusion
4	Oral Resveratrol Before ERCP Redused Overall Pancreatitis in Patients Undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP): A Multi-center, Single-blinded, Randomized Controlled Trial	Unknown status	NCT02947932	Phase 4	Resveratrol;Indomethacin
5	Effect Observation Study of COX-2 Inhibitor to Prevent Post-ERCP Pancreatitis	Unknown status	NCT02964403	Phase 4	Cox-2;Indomethacin
6	Escalade or Deseacalade Antibiotic Use in Severe Acute Pancreatitis	Unknown status	NCT01992198	Phase 4	cefoperazone + metronidazole;Somatostatin;Meropenem
7	Pancreatitis CytoSorbents (CytoSorb®) Inflammatory Cytokine Removal: A Prospective Study.	Unknown status	NCT03082469	Phase 4
8	Prophylactic Pancreatic Duct Stent Placement After Endoscopic Snare Papillectomy of Duodenal Major Papillary Tumors; Prospective, Randomized, Controlled Study	Unknown status	NCT01737463	Phase 4
9	The Effect of Application of Fibrinogen/Thrombin-coated Collagen Patch (TachoSil®) in Pancreaticojejunostomy for Prevention of Pancreatic Fistula After Pancreatoduodenectomy	Unknown status	NCT03269955	Phase 4	Fibrinogen/thrombin-coated collagen patch
10	Application of Pinaverium Bromide in the Treatment of Patients With Post-cholecystectomy Sphincter of Oddi Dysfunction (SOD): A Randomized, Controlled and Multicenter Clinical Study	Unknown status	NCT02833103	Phase 4	Danshu Capsules;Pinaverium Bromide
11	DOLCE Study: Day-care Versus Overnight-stay Laparoscopic Cholecystectomy Randomized, Controlled Trial	Unknown status	NCT01052727	Phase 4
12	Dose Related Decrease in Triglycerides in Patients With Hypertriglyceridemia and Treated With Lovaza.	Unknown status	NCT00934219	Phase 4	Omega-3-Acid Ethyl Esters
13	An Open Pilot Study to Evaluate the Efficacy and Safety, Tolerability of Raltegravir（RAL）in Treatment-experienced HIV-1 Infected Adult Chinese Patients	Unknown status	NCT01201239	Phase 4	raltegravir
14	Prospective Assessment of Valproate on Ethanol Withdrawal	Unknown status	NCT03235531	Phase 4	Valproate;Lorazepam
15	Evaluation of the Digestive and Metabolic Utilisation of Dietary Protein in Patients With Chronic Pancreatitis	Completed	NCT00957151	Phase 4	Creon
16	Randomized Controlled Trial on Sterile Fluid Collections Management in Acute Pancreatitis	Completed	NCT00786929	Phase 4	Conservative treatment
17	Evaluation of Pancreatic Tissue Penetration of Meronem® in the Prophylaxis of Septic Complications in Severe Pancreatitis	Completed	NCT00318994	Phase 4	Meropenem
18	Imipenem Prophylaxis of Infectious Complications in Patients With Acute Pancreatitis	Completed	NCT02897206	Phase 4	Imipenem;Placebo
19	A Prospective Study of Celiac Block Technique: One Injection or Two?	Completed	NCT00583479	Phase 4
20	Timing of Indomethacin Administration for the Prevention of Post-ERCP Pancreatitis (PEP)	Completed	NCT02111707	Phase 4	Rectal indomethacin 100mg one time before or after ERCP
21	Double-blind Randomized Study to Determine the Efficacy of Intramuscular Vitamin D3 Supplementation in Tropical Calcific Pancreatitis	Completed	NCT00956839	Phase 4	Vitamin D3 (Cholecalciferol)
22	Assess the Effect of Erythromycin on the Rate of Success in Placement of a Self-propelled Feeding Tube	Completed	NCT00999232	Phase 4	Erythromycin;Placebo
23	A Multicentre, Randomised, Double-blind, Placebo-controlled, Study on the Use of Prophylactic Meropenem Therapy in Subjects With Severe Acute Necrotizing Pancreatitis	Completed	NCT00061438	Phase 4	meropenem
24	A Prospective Randomised Trial of 0.025 Wire Guided Cannulation Versus Current Practice 0.035 Wire Guided Cannulation	Completed	NCT01408264	Phase 4
25	The Impact of Early Enteral Nutrition on the Clinical Outcomes of Severe Acute Pancreatitis Patients: A Randomized Control Trial	Completed	NCT00995098	Phase 4
26	Diclophenac Potassium Versus Ceftazidime for Reduction of Post ERCP Pancreatitis in Average Risk Patients-double Blind, Randomised Controlled Trial	Completed	NCT01784445	Phase 4	Ceftazidime
27	Enteral Nutrition for Treatment of Acute Pancreatitis - a Prospective, Randomized Clinical Trial	Completed	NCT01965873	Phase 4
28	APCAP - Activated Protein C in Severe Acute Pancreatitis: A Double-blind Randomized Human Pilot Trial	Completed	NCT01017107	Phase 4	Activated protein C
29	Dexmedetomidine vs Placebo in ERCP Sedation.A Randomized Pilot Study	Completed	NCT01070680	Phase 4	Precedex;sodium chlorid 0,9%
30	Nutritional and Metabolic Evaluation of a Tube Feeding Immune Enhancing Diet in ICU Patients	Completed	NCT00560157	Phase 4
31	A Double-Blind, Randomized, Placebo Controlled Intervention Study to Assess the Impact of Sitagliptin 100 mg/Day for 1 Year on Insulin Independence Following Pancreatectomy and Autoislet Transplantation	Completed	NCT01186562	Phase 4	Sitagliptin;Placebo
32	DGT Versus TPS in Patients With Initial PD Cannulation by Chance; Prospective Randomized Multi-center Study	Completed	NCT01744847	Phase 4
33	The Correlations Between Early Enteral Nutrition and Intra-abdominal Pressure in Severe Acute Pancreatitis	Completed	NCT01507766	Phase 4	early enteral nutrition;Delayed enteral nutrition
34	Enzyme Substitution in Exocrine Pancreatic Insufficiency; Self Administration Against a Fixed Dose Regimen	Completed	NCT01430234	Phase 4	Panzytrat 25.000 FIP-E units of Lipase
35	Covered Versus Uncovered Metal Stents for Management of Distal Malignant Biliary Obstruction? Results of a Randomized Prospective Study.	Completed	NCT00280709	Phase 4
36	Studie Naar De Effectiviteit Van Ursodeoxycholzuur Ter Preventie Van Galsteen-Gerelateerde Klachten Bij patiënten in Afwachting Van Een Cholecystectomie	Completed	NCT00161083	Phase 4	ursodeoxycholic acid
37	Pilot Study for the Evaluation of the Safety and the Feasibility of Treatment Simplification to Atazanavir/Ritonavir + Lamivudine in Patients Stably Treated With Two NRTIs + Atazanavir/Ritonavir With Optimal Virologic Response.	Completed	NCT00885482	Phase 4	Lamiduvine (Epivir);Atazanavir (Reyataz);Ritonavir (Norvir)
38	A Study of Safety and Efficacy of Leflunomide for Maintenance of Remission in IgG4 Related Disease	Completed	NCT02703194	Phase 4	Prednisone;Leflunomide
39	Beijing Chao-Yang Hospital, Capital Medical University	Completed	NCT03297879	Phase 4	Exenatide or metformin hydrochloride
40	Etomidate With Meperidine vs Midazolam With Meperidine for Sedation During Endodscopic Retrograde Cholangiopancreatogram (ERCP)	Completed	NCT02027311	Phase 4	Etomidate;Midazolam;Meperidine
41	A Pilot Study for the Use of Biomarkers and Early Treatment of Invasive Candidiasis in ICU Patients	Completed	NCT01734525	Phase 4	Anidulafungin
42	Use of Polyethylene Glycolic Acid or Tachocomb to Prevent Pancreatic Fistula Following Distal Pancreatectomy: Prospective Multicenter Randomized Study	Completed	NCT01550406	Phase 4
43	A Phase IV, Randomized, Double-blind, Placebo-controlled, Parallel-group Trial to Assess the Effect of 12-week Treatment With the Glucagon-like Peptide-1 Receptor Agonist (GLP-1RA) Liraglutide or Dipeptidyl Peptidase-4 Inhibitor (DPP-4i) Sitagliptin on the Cardiovascular, Renal and Gastrointestinal System in Insulin-naïve Patients With Type 2 Diabetes (T2DM).	Completed	NCT01744236	Phase 4	Liraglutide;Sitagliptin;Exenatide;Liraglutide placebo;Sitagliptin placebo;Exenatide placebo;L-NMMA
44	Exploratory, Cross-sectional Study to Compare the Virologic Efficacy in Cerebrospinal Fluid (CSF) and Neurocognitive State in Patients Infected by HIV-1 Long-term Treatment (> 3 Years) With Lopinavir / Ritonavir Monotherapy	Completed	NCT01116817	Phase 4	Lumbar puncture (Lopinavir/ritonavir monotherapy);Lumbar puncture (HAART: Lopinavir/ritonavir + 2 NRTI)
45	A Randomised, Double Blind Cross-over Study of Serial MRCP Following Morphine-neostigmine and Secretin Provocation in Healthy Volunteers	Completed	NCT01134848	Phase 4	Morphine;Neostigmine;0.9% saline;Secretin;0.9% saline
46	Effect of Early Nutritional Therapy on Frailty, Functional Outcomes and Recovery of Undernourished Medical Inpatients Trial: The EFFORT Trial	Completed	NCT02517476	Phase 4
47	Evaluation of Safety and Efficacy of Raltegravir/Darunavir Combination in Antiretroviral-Naive Patients	Completed	NCT00677300	Phase 4	Raltegravir;Darunavir;Ritonavir;Tenofovir/Emtricitabine
48	A Comparison of Effectiveness of Oral Sucrolfate, Alginate and Hydrotalcide in Dispeptic Pain Treatment: Randomized Trial	Completed	NCT03635372	Phase 4	Alginate;Sucralfate;Hydrotalcite
49	Randomised and Prospective Clinical Study to Evaluate the Efficacy and Safety of Lopinavir/Ritonavir Monotherapy Versus Darunavir/Ritonavir Monotherapies as Simplification Switching Strategies of PI/NNRTI-Triple Therapy Based-Regimens	Completed	NCT00994344	Phase 4	Darunavir/ritonavir;Lopinavir/ritonavir
50	To Study the Effects of Lipid Emulsion on Hemodynamics in Organophosphate Compound Poisoning	Completed	NCT03564574	Phase 4

Search NIH Clinical Center for Pancreatitis

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Propantheline

Propantheline Bromide

Sources

Genetic Tests for Pancreatitis

Genetic tests related to Pancreatitis:

#	Genetic test	Affiliating Genes
1	Pancreatitis ²⁹

Sources

Anatomical Context for Pancreatitis

MalaCards organs/tissues related to Pancreatitis:

⁴⁰

Pancreas, Testes, Liver, Lung, Colon, Kidney, Neutrophil

Sources

Publications for Pancreatitis

Articles related to Pancreatitis:

(show top 50) (show all 30199)

#	Title	Authors	PMID	Year
1	The natural history of hereditary pancreatitis: a national series. ⁶¹ ⁵⁴ ²⁴	Rebours V...Levy P	18755888	2009
2	Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis. ⁶¹ ⁵⁴ ²⁴	Masson E...Ferec C	18172691	2008
3	Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis. ²⁴ ⁶¹ ⁵⁴	Rosendahl J...Sahin-Toth M	18059268	2008
4	Diabetes mellitus in Tropical Chronic Pancreatitis Is Not Just a Secondary Type of Diabetes. ²⁴ ⁵⁴ ⁶¹	Rossi L...Gyr N	15258409	2004
5	SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis. ⁶¹ ⁵⁴ ²⁴	Pfutzer RH...Whitcomb DC	10982753	2000
6	Prevention of Severe Acute Pancreatitis With Cyclooxygenase-2 Inhibitors: A Randomized Controlled Clinical Trial. ⁶¹ ⁴²	Huang Z...Huang L	32142484	2020
7	Discussion on: The morbidity of C. difficile in necrotizing pancreatitis. ⁴² ⁶¹	Maatman TK...Zyromski NJ	32199538	2020
8	Total pancreatectomy and islet autotransplantation in chronic pancreatitis: recommendations from PancreasFest. ⁶¹ ²⁴	Bellin MD...Yadav D	24555976	2014
9	Pancreatitis-diabetes-pancreatic cancer: summary of an NIDDK-NCI workshop. ²⁴ ⁶¹	Andersen DK...Whitcomb DC	24152948	2013
10	Variants in CPA1 are strongly associated with early onset chronic pancreatitis. ²⁴ ⁶¹	Witt H...Sahin-Toth M	23955596	2013
11	Detection, evaluation and treatment of diabetes mellitus in chronic pancreatitis: recommendations from PancreasFest 2012. ⁶¹ ²⁴	Rickels MR...PancreasFest Recommendation Conference Participants	23890130	2013
12	CFTR, SPINK1, CTRC and PRSS1 variants in chronic pancreatitis: is the role of mutated CFTR overestimated? ²⁴ ⁶¹	Rosendahl J...Witt H	22427236	2013
13	Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus. ²⁴ ⁶¹	Banks PA...Acute Pancreatitis Classification Working Group	23100216	2013
14	Endoscopic therapy is effective for patients with chronic pancreatitis. ⁶¹ ²⁴	Clarke B...Yadav D	22245964	2012
15	Whole exome sequencing identifies multiple, complex etiologies in an idiopathic hereditary pancreatitis kindred. ⁶¹ ²⁴	LaRusch J...Whitcomb DC	22572128	2012
16	Genetics of pancreatitis: an update for clinicians and genetic counselors. ²⁴ ⁶¹	Solomon S...Whitcomb DC	22314809	2012
17	Drug-induced pancreatitis. ⁶¹ ²⁴	Nitsche C...Mayerle J	22314811	2012
18	Oxidative stress in chronic pancreatitis: pathophysiological relevance and management. ⁶¹ ²⁴	Tandon RK...Garg PK	21902596	2011
19	Genetics of pancreatitis. ²⁴ ⁶¹	LaRusch J...Whitcomb DC	21844754	2011
20	Quality of life improves for pediatric patients after total pancreatectomy and islet autotransplant for chronic pancreatitis. ⁶¹ ²⁴	Bellin MD...Sutherland DE	21683160	2011
21	Imaging of acute pancreatitis. ²⁴ ⁶¹	O'Connor OJ...Maher MM	21785045	2011
22	High incidence of PRSS1 and SPINK1 mutations in Korean children with acute recurrent and chronic pancreatitis. ²⁴ ⁶¹	Lee YJ...Yoo HW	21415673	2011
23	Correlation of histopathology, islet yield, and islet graft function after islet autotransplantation in chronic pancreatitis. ⁶¹ ²⁴	Kobayashi T...Sutherland DE	21404456	2011
24	Use and perceived effectiveness of non-analgesic medical therapies for chronic pancreatitis in the United States. ⁶¹ ²⁴	Burton F...North American Pancreatic Study Group	21083584	2011
25	Therapeutic implications of oxidative stress in acute and chronic pancreatitis. ²⁴ ⁶¹	Petrov MS	20543682	2010
26	The role of alcohol and smoking in pancreatitis. ⁶¹ ²⁴	Yadav D...Whitcomb DC	20125091	2010
27	Outcomes of interventional ERCP in hereditary pancreatitis. ⁶¹ ²⁴	Dever JB...Kozarek R	19713862	2010
28	Alcohol consumption, cigarette smoking, and the risk of recurrent acute and chronic pancreatitis. ⁶¹ ²⁴	Yadav D...North American Pancreatic Study Group	19506173	2009
29	Assessment of chronic pancreatitis: utility of diffusion-weighted MR imaging with secretin enhancement. ²⁴ ⁶¹	Akisik MF...Rydberg M	19001148	2009
30	A randomized controlled trial of antioxidant supplementation for pain relief in patients with chronic pancreatitis. ⁶¹ ²⁴	Bhardwaj P...Acharya SK	18952082	2009
31	Hereditary pancreatitis caused by a double gain-of-function trypsinogen mutation. ⁶¹ ²⁴	Masson E...Ferec C	18461367	2008
32	Copy number variations in chronic pancreatitis. ⁶¹ ²⁴	Chen JM...Ferec C	19287144	2008
33	Risk of pancreatic adenocarcinoma in patients with hereditary pancreatitis: a national exhaustive series. ²⁴ ⁶¹	Rebours V...Levy P	18184119	2008
34	Trypsinogen copy number mutations in patients with idiopathic chronic pancreatitis. ²⁴ ⁶¹	Masson E...Ferec C	18063422	2008
35	Hereditary pancreatitis amlodipine trial: a pilot study of a calcium-channel blocker in hereditary pancreatitis. ⁶¹ ²⁴	Morinville VD...Whitcomb DC	18090235	2007
36	Genetic counseling for nonsyndromic pancreatitis. ⁶¹ ²⁴	Fink EN...Whitcomb DC	17533082	2007
37	Pain in chronic pancreatitis and pancreatic cancer. ⁶¹ ²⁴	Fasanella KE...Whitcomb DC	17533083	2007
38	13C-mixed triglyceride breath test to assess oral enzyme substitution therapy in patients with chronic pancreatitis. ⁶¹ ²⁴	Dominguez-Munoz JE...Iglesias-Rey M	17445754	2007
39	Yoga: a tool for improving the quality of life in chronic pancreatitis. ²⁴ ⁶¹	Sareen S...Gajebasia NK	17230607	2007
40	Practice guidelines in acute pancreatitis. ⁶¹ ²⁴	Banks PA...Practice Parameters Committee of the American College of Gastroenterology	17032204	2006
41	Cigarette smoking accelerates progression of alcoholic chronic pancreatitis. ²⁴ ⁶¹	Maisonneuve P...Ammann RW	15753536	2005
42	Genetic counseling for hereditary pancreatitis--the role of molecular genetics testing for the cationic trypsinogen gene, cystic fibrosis and serine protease inhibitor Kazal type 1. ⁵⁴ ²⁴	Ellis I	15528021	2004
43	Cigarette smoking as a risk factor for pancreatic cancer in patients with hereditary pancreatitis. ²⁴ ⁶¹	Lowenfels AB...DiMagno EP	11448279	2001
44	Chronic pancreatitis: diagnosis, classification, and new genetic developments. ²⁴ ⁶¹	Etemad B...Whitcomb DC	11179244	2001
45	Pancreatitis induced by environmental toxins. ²⁴ ⁶¹	Khurana V...Barkin JS	11138962	2001
46	Antioxidant treatment in hereditary pancreatitis. A pilot study on three young patients. ²⁴ ⁶¹	Uomo G...Rabitti PG	11303976	2001
47	Genetic testing for hereditary pancreatitis: guidelines for indications, counselling, consent and privacy issues. ⁶¹ ²⁴	Ellis I...Consensus Committees of the European Registry of Hereditary Pancreatic Diseases, Midwest Multi-Center Pancreatic Study Group, International Association of Pancreatology	12120217	2001
48	Pancreatic cancer in hereditary pancreatitis: consensus guidelines for prevention, screening and treatment. ²⁴ ⁶¹	Ulrich CD...Consensus Committees of the European Registry of Hereditary Pancreatic Diseases, Midwest Multi-Center Pancreatic Study Group, International Association of Pancreatology	12120218	2001
49	Early prediction of severity in acute pancreatitis by urinary trypsinogen activation peptide: a multicentre study. ⁶¹ ²⁴	Neoptolemos JP...Puolakkainen PA	10859041	2000
50	Hereditary pancreatitis: new insights, new directions. ⁶¹ ²⁴	Whitcomb DC...Ulrich CD	11030605	1999

Sources

Genes for Pancreatitis

Genes/enhancers related to Pancreatitis (1 elite genes):

(show top 50) (show all 57)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	TMEM67	Transmembrane Protein 67	Protein Coding	406.6	Pathogenic/Likely pathogenic ⁶ GeneCards inferred via : Variants (show sections)
2	SPINK1	Serine Peptidase Inhibitor Kazal Type 1	Protein Coding	66.96	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Summaries Functions Variants (show sections)	12560856 18076731 10982753 (more) 12743777 17003641 16958672 18852684 15980664 19593166 15758663 12227654 16354799 14526128 11916201 16954950 15084977 12483248 15528018 15238770 12649567 12825076 17318339 18680693 15753612 17033331 12676913 12011155 12120224 12120222 1723534 19404200 15329520 12452372 12120202 11368029 17163998 19077465 18442214 17981921 16823394 12853682 17681820 16958673 15725720 14507909 17641557 15957615 18706099 17990360 14688470
2	SPINK1::GH05J147830	TSS distance: +7.5kb Elite enhancer with elite association with SPINK1			Curated enhancer-disease association ²³ ¹⁴	25910213
3	PRSS1	Serine Protease 1	Protein Coding	57.41	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)	18852684 15786540 12765848 (more) 18442214 20387681 20001681 18076731 16954950 18755888 16354799 11702203 17855255 15528018 14695529 12011155 15749232 15082592 16958673 15329520 17981921 15800694 11260229 16823394 15725720 11708864
4	REG3A	Regenerating Family Member 3 Alpha	Protein Coding	52.38	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Gene name Expressions Domains & Families (show sections)	9026481 11396234 10325788 (more) 7890213 15870231 19084446 8188210 9382059 18641332 11938036 15765495 8119544 7895535 10695350 15850341
5	CTRC	Chymotrypsin C	Protein Coding	44.3	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Variants (show sections)	18059268 18172691
6	APOC2	Apolipoprotein C2	Protein Coding	37.95	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)	19034041 12120223 19534808 (more) 9665414
7	CFTR	CF Transmembrane Conductance Regulator	Protein Coding	34.47	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Variants (show sections)	15233679 12779072 9725922 (more) 12227654 12759680 10950058 17003641 17943404 12560856 16193325 15758663 15987793 17981921 18076731 16954950 12120234 11729110 20080093 15238770 17575549 11462247 10872419 14526128 11276378 10681187 19359437 17681820 15775704 12452372 11446679 10801389 10773783 18360295 15772171 17033331 14567084 12661515 12120222 19593166 19885835 19106752 18286677 16764792 12422349 11737931 18442214 15749233 12940920 20332619 16823394 15725720 15528020 11151920 18680693 15957615 16998246 10503135 15528021 16093768 14688470
8	REG1A	Regenerating Family Member 1 Alpha	Protein Coding	31.67	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Domains & Families (show sections)	11884767 16360171 8482198 (more) 18953250 9057183 8501356 1698685 1578808
9	PRSS2	Serine Protease 2	Protein Coding	31.61	Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Summaries Variants (show sections)	14695529 19077465
10	LPL	Lipoprotein Lipase	Protein Coding	30.43	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications (show sections)	19034041 19534808 9186902 (more) 8554252 16716106 10735636 18720707 8486765 8325986 7578404 12120223 15840743 11757580 11134145 10499250 15719847 9717057 18936103 18752369 17706445 16972177 15353045 18350203 16259561 8843465 16106048 9323055 8728326 18983441 8725150 8839720 10199753 10400113
11	CPB1	Carboxypeptidase B1	Protein Coding	30.35	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Summaries (show sections)	1688389 7624299 9261609
12	VMP1	Vacuole Membrane Protein 1	Protein Coding	28.64	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Summaries Functions (show sections)
13	CCK	Cholecystokinin	Protein Coding	25.43	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	10589592 11185710 15104368 (more) 9094154 10026434 10759224 2244806 17384281 1713673 10570344 17460968 14576492 11842000 9832635 1601028 18336661 18185062 19331832 15570466 18336667 17059357 8975946 8235437 19122497 14576490 17324928
14	SCT	Secretin	Protein Coding	25.28	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	1699712 12852778 15258409 (more) 2368550 2033325 17999059
15	CPA1	Carboxypeptidase A1	Protein Coding	25.25	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Summaries (show sections)
16	CASR	Calcium Sensing Receptor	Protein Coding	24.67	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications (show sections)	17853337 16497624 18680227 (more) 9039332
17	PNLIP	Pancreatic Lipase	Protein Coding	24.43	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	11835532 17069643 18983441 (more) 19293788 16972177 18936103 12271590 2375312
18	PLA2G2A	Phospholipase A2 Group IIA	Protein Coding	24.04	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Functions (show sections)	2253331 8121178 10077051 (more) 12142744
19	SST	Somatostatin	Protein Coding	23.04	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	18953260 10228257 14633959 (more) 12555014 15290665 11709520 12297762 14748874 7908715 9594194 11459565 1380475 17559376 9540874 12555015 17383459 16584693 7701265 17708853 18155442 16198632 11641935 12943494 12555013 7492005 12555018 10804774 18494044 17351806 10514124 8592430 8956180 10489135 1383099 19251531 11370223 11704779 17998925 12921486 8813466 1803287 9539654
20	REG1B	Regenerating Family Member 1 Beta	Protein Coding	22.77	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Domains & Families (show sections)
21	TMPRSS15	Transmembrane Serine Protease 15	Protein Coding	22.48	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	12371983 11445702 10691375 (more) 10722028
22	MUC4	Mucin 4, Cell Surface Associated	Protein Coding	22.23	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Expressions (show sections)
23	CRP	C-Reactive Protein	Protein Coding	21.5	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	11577303 10877218 9058297 (more) 7533521 15103565 14724436 9155580 10562589 12432185 10717921 10494604 20517765 19852292 12764986 7517379 11935133 7539940 8017183 19057957 11176162 9382059 9855088 12701012 12732100 17506001 17907086
24	LMF1	Lipase Maturation Factor 1	Protein Coding	21.46	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
25	AMY2A	Amylase Alpha 2A	Protein Coding	21.29	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	19520060 19001184
26	APOA5	Apolipoprotein A5	Protein Coding	20.95	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
27	REG3G	Regenerating Family Member 3 Gamma	Protein Coding	20.47	DISEASES inferred ¹⁵ GeneCards inferred via : Gene name Domains & Families (show sections)
28	ELANE	Elastase, Neutrophil Expressed	Protein Coding	20.24	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	1462874 18486906 1280365 (more) 17523321 7828993 10337184 17460968 10206480 1690443 7517379 9245935 1582445 10352979 1688526 1713406
29	UBR1	Ubiquitin Protein Ligase E3 Component N-Recognin 1	Protein Coding	20.07	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
30	CTSB	Cathepsin B	Protein Coding	19.94	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	11312265 8500736 17990360 (more) 18706099 12102727 16905693 9251238
31	GCG	Glucagon	Protein Coding	19.5	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	20371755 20305008
32	PRSS3	Serine Protease 3	Protein Coding	19.5	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	16029158 9832635
33	CEL	Carboxyl Ester Lipase	Protein Coding	19.09	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	15841033 2403740 8424803
34	CA2	Carbonic Anhydrase 2	Protein Coding	18.2	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	11950899 19119794 18580434
35	SMAD4	SMAD Family Member 4	Protein Coding	17.76	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	17436386
36	BRCA2	BRCA2 DNA Repair Associated	Protein Coding	17.52	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	12555988 9438601
37	MIR21	MicroRNA 21	RNA Gene	17.2	DISEASES inferred ¹⁵ ¹⁵ GeneCards inferred via : Publications (show sections)
38	INS	Insulin	Protein Coding	17.09	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
39	CCKAR	Cholecystokinin A Receptor	Protein Coding	17.08	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	10026434 10705468
40	CELA3B	Chymotrypsin Like Elastase 3B	Protein Coding	16.89	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
41	GGT1	Gamma-Glutamyltransferase 1	Protein Coding	16.57	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	2251597 1725573 7911669 (more) 15773422 10430683
42	JMJD6	Jumonji Domain Containing 6, Arginine Demethylase And Lysine Hydroxylase	Protein Coding	16.52	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Expressions (show sections)
43	PTF1A	Pancreas Associated Transcription Factor 1a	Protein Coding	16.39	DISEASES inferred ¹⁵ GeneCards inferred via : localization (show sections)
44	PPY	Pancreatic Polypeptide	Protein Coding	16.37	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
45	IL6	Interleukin 6	Protein Coding	16.32	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
46	ALDH2	Aldehyde Dehydrogenase 2 Family Member	Protein Coding	16.3	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	8985275 18773092 10235286
47	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	16.16	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
48	TP53	Tumor Protein P53	Protein Coding	16.13	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
49	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	15.93	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
50	TNF	Tumor Necrosis Factor	Protein Coding	15.8	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Pancreatitis

ClinVar genetic disease variations for Pancreatitis:

⁶ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	GRCh37 Pos	GRCh38 Pos
1	TMEM67	NM_153704.6(TMEM67):c.1843T>C (p.Cys615Arg)	SNV	Pathogenic/Likely pathogenic	1383	rs201893408	8:94808198-94808198	8:93795970-93795970
2	TMEM67	NM_153704.6(TMEM67):c.1321C>T (p.Arg441Cys)	SNV	Pathogenic/Likely pathogenic	217725	rs752362727	8:94798483-94798483	8:93786255-93786255
3	CFTR	NM_000492.4(CFTR):c.1523T>G (p.Phe508Cys)	SNV	Conflicting interpretations of pathogenicity	7126	rs74571530	7:117199648-117199648	7:117559594-117559594
4	CFTR	NM_000492.4(CFTR):c.2991G>C (p.Leu997Phe)	SNV	Conflicting interpretations of pathogenicity	7229	rs1800111	7:117250575-117250575	7:117610521-117610521
5	CFTR	NM_000492.4(CFTR):c.1584G>A (p.Glu528=)	SNV	Conflicting interpretations of pathogenicity	43576	rs1800095	7:117199709-117199709	7:117559655-117559655

Copy number variations for Pancreatitis from CNVD:

⁷

#	CNVD ID	Chromosome	Start	End	Type	Gene Symbol	CNVD Disease
1	194974	5	147184338	147191453	Deletion	SPINK1	Pancreatitis
2	220321	7	137300000	142800000	Triplication	PRSS1	Pancreatitis
3	220322	7	137300000	142800000	Triplication	PRSS2	Pancreatitis
4	221070	7	142136892	142140501	Triplication	PRSS1	Pancreatitis
5	221298	7	142800000	147500000	Triplication	PRSS1	Pancreatitis

Sources

Expression for Pancreatitis

Search GEO for disease gene expression data for Pancreatitis.

Sources

Pathways for Pancreatitis

Pathways related to Pancreatitis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism of water-soluble vitamins and cofactors ⁶⁵ Show member pathways [2Fe-2S] iron-sulfur cluster biosynthesis ¹ Biotin transport and metabolism ⁶⁵ biotin-carboxyl carrier protein assembly ¹ coenzyme A biosynthesis ¹ Coenzyme A biosynthesis ⁶⁵ flavin biosynthesis ¹ folate polyglutamylation ¹ glycine/serine biosynthesis ¹ Metabolism of folate and pterines ⁶⁵ Metabolism of vitamins and cofactors ⁶⁵ molybdenum cofactor biosynthesis ¹ Molybdenum cofactor biosynthesis ⁶⁵ thiamin salvage III ¹ thio-molybdenum cofactor biosynthesis ¹ Vitamin B1 (thiamin) metabolism ⁶⁵ Vitamin B2 (riboflavin) metabolism ⁶⁵ Vitamin B5 (pantothenate) metabolism ⁶⁵ Vitamin C (ascorbate) metabolism ⁶⁵ Vitamins B6 activation to pyridoxal phosphate ⁶⁵	11.96	PRSS1 PNLIP LPL CTRC APOC2
2	Pancreatic secretion ³⁶	11.29	SCT PRSS2 PRSS1 PNLIP PLA2G2A CPB1
3	Cobalamin (Cbl, vitamin B12) transport and metabolism ⁶⁵	10.58	PRSS1 CTRC
4	Gastric acid production ¹	10	SCT CCK

Sources

GO Terms for Pancreatitis

Cellular components related to Pancreatitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.86	SST SPINK1 SCT REG3A REG1B REG1A
2	extracellular space	GO:0005615	9.5	SST SPINK1 SCT REG3A REG1B REG1A
3	very-low-density lipoprotein particle	GO:0034361	9.26	LPL APOC2
4	chylomicron	GO:0042627	9.16	LPL APOC2

Biological processes related to Pancreatitis according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	proteolysis	GO:0006508	9.91	PRSS2 PRSS1 CTRC CPB1 CPA1
2	positive regulation of cell proliferation	GO:0008284	9.88	REG3A REG1B REG1A CCK CASR
3	antimicrobial humoral immune response mediated by antimicrobial peptide	GO:0061844	9.58	REG3A REG1B REG1A
4	sperm capacitation	GO:0048240	9.54	SPINK1 CFTR
5	retinoid metabolic process	GO:0001523	9.54	PNLIP LPL APOC2
6	cobalamin metabolic process	GO:0009235	9.52	PRSS1 CTRC
7	response to peptide hormone	GO:0043434	9.5	REG3A REG1B REG1A
8	positive regulation of macrophage derived foam cell differentiation	GO:0010744	9.49	PLA2G2A LPL
9	very-low-density lipoprotein particle remodeling	GO:0034372	9.46	LPL APOC2
10	lipid catabolic process	GO:0016042	9.46	PNLIP PLA2G2A LPL APOC2
11	chylomicron remodeling	GO:0034371	9.43	LPL APOC2
12	antimicrobial humoral response	GO:0019730	9.43	REG3A PRSS2 PLA2G2A
13	digestion	GO:0007586	9.26	SST PRSS2 PRSS1 CCK
14	cell wall disruption in other organism	GO:0044278	8.8	REG3A REG1B REG1A

Molecular functions related to Pancreatitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hydrolase activity	GO:0016787	9.76	PRSS2 PRSS1 PNLIP PLA2G2A LPL CTRC
2	peptidase activity	GO:0008233	9.72	PRSS2 PRSS1 CTRC CPB1 CPA1
3	signaling receptor activity	GO:0038023	9.56	REG3A REG1B REG1A CASR
4	hormone activity	GO:0005179	9.54	SST SCT CCK
5	triglyceride lipase activity	GO:0004806	9.43	PNLIP LPL
6	lipase activity	GO:0016298	9.4	PNLIP LPL
7	peptidoglycan binding	GO:0042834	9.13	REG3A REG1B REG1A
8	oligosaccharide binding	GO:0070492	8.8	REG3A REG1B REG1A

Sources

Sources for Pancreatitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia

Pancreatitis

Aliases & Classifications for Pancreatitis

MalaCards integrated aliases for Pancreatitis:

Classifications:

External Ids:

Summaries for Pancreatitis

Related Diseases for Pancreatitis

Diseases in the Pancreatitis family:

Diseases related to Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Pancreatitis:

Symptoms & Phenotypes for Pancreatitis

UMLS symptoms related to Pancreatitis:

GenomeRNAi Phenotypes related to Pancreatitis according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Pancreatitis:

Drugs & Therapeutics for Pancreatitis

Drugs for Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Genetic Tests for Pancreatitis

Genetic tests related to Pancreatitis:

Anatomical Context for Pancreatitis

MalaCards organs/tissues related to Pancreatitis:

Publications for Pancreatitis

Articles related to Pancreatitis:

Genes for Pancreatitis

Genes/enhancers related to Pancreatitis (1 elite genes):

Variations for Pancreatitis

ClinVar genetic disease variations for Pancreatitis:

Copy number variations for Pancreatitis from CNVD:

Expression for Pancreatitis

Pathways for Pancreatitis

Pathways related to Pancreatitis according to GeneCards Suite gene sharing:

GO Terms for Pancreatitis

Cellular components related to Pancreatitis according to GeneCards Suite gene sharing:

Biological processes related to Pancreatitis according to GeneCards Suite gene sharing:

Molecular functions related to Pancreatitis according to GeneCards Suite gene sharing:

Sources for Pancreatitis

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :