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Pancreatitis

Categories: Endocrine diseases, Genetic diseases, Rare diseases, Gastrointestinal diseases, Bone diseases, Immune diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Pancreatitis

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MalaCards integrated aliases for Pancreatitis:

Name: Pancreatitis 12 24 29 55 6 43 44 15 40 73

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Endocrine diseases Gastrointestinal diseases Bone diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:4989
ICD10 33 K85.9
MeSH 44 D010195
NCIt 50 C3306
UMLS 73 C0030305
Sources

Summaries for Pancreatitis

About this section
MedlinePlus : 43 The pancreas is a large gland behind the stomach and close to the first part of the small intestine. It secretes digestive juices into the small intestine through a tube called the pancreatic duct. The pancreas also releases the hormones insulin and glucagon into the bloodstream. Pancreatitis is inflammation of the pancreas. It happens when digestive enzymes start digesting the pancreas itself. Pancreatitis can be acute or chronic. Either form is serious and can lead to complications. Acute pancreatitis occurs suddenly and usually goes away in a few days with treatment. It is often caused by gallstones. Common symptoms are severe pain in the upper abdomen, nausea, and vomiting. Treatment is usually a few days in the hospital for intravenous (IV) fluids, antibiotics, and medicines to relieve pain. Chronic pancreatitis does not heal or improve. It gets worse over time and leads to permanent damage. The most common cause is heavy alcohol use. Other causes include cystic fibrosis and other inherited disorders, high levels of calcium or fats in the blood, some medicines, and autoimmune conditions. Symptoms include nausea, vomiting, weight loss, and oily stools. Treatment may also be a few days in the hospital for intravenous (IV) fluids, medicines to relieve pain, and nutritional support. After that, you may need to start taking enzymes and eat a special diet. It is also important to not smoke or drink alcohol. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Pancreatitis is related to autoimmune pancreatitis and pancreatic agenesis 1, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Pancreatitis is SPINK1 (Serine Peptidase Inhibitor, Kazal Type 1), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and Pancreatic secretion. The drugs Menthol and Meropenem have been mentioned in the context of this disorder. Affiliated tissues include pancreatic islet, pancreas and liver, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 76 Pancreatitis is inflammation of the pancreas. The pancreas is a large organ behind the stomach that... more...

GeneReviews: NBK190101
Sources

Related Diseases for Pancreatitis

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Diseases in the Pancreatitis family:

Pancreatitis, Hereditary Acute Pancreatitis
Prss1-Related Hereditary Pancreatitis Autoimmune Pancreatitis
Autoimmune Pancreatitis Type 2 Autoimmune Pancreatitis Type 1
Recurrent Acute Pancreatitis

Diseases related to Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1177)
# Related Disease Score Top Affiliating Genes
1 autoimmune pancreatitis 34.8 CFTR PRSS1
2 pancreatic agenesis 1 34.3 CFTR PNLIP SCT SPINK1
3 exocrine pancreatic insufficiency 34.2 CCK CFTR PNLIP SCT
4 tropical calcific pancreatitis 34.2 CTRC PRSS1 PRSS2 REG1A SPINK1
5 pancreatic gastrinoma 34.1 SCT SST
6 pancreatic steatorrhea 33.9 CCK PNLIP PRSS1 SCT
7 pancreatic cholera 33.8 CCK SCT SST
8 pancreatitis, hereditary 33.7 CASR CFTR CPA1 CTRC PRSS1 PRSS2
9 vipoma 33.3 SCT SST
10 recurrent acute pancreatitis 33.1 CFTR CTRC LPL PRSS1 SCT SPINK1
11 alcoholic pancreatitis 32.9 CCK CFTR LPL PRSS1 SCT SPINK1
12 duodenal atresia 32.8 CFTR SCT
13 hyperinsulinemic hypoglycemia, familial, 2 32.7 SCT SST
14 biliary dyskinesia 32.6 CCK SCT
15 multiple endocrine neoplasia, type i 32.3 CASR SCT SST
16 cystic fibrosis 32.3 CFTR PNLIP PRSS1 REG3A SCT SPINK1
17 familial lipoprotein lipase deficiency 32.2 APOC2 LPL PNLIP
18 apolipoprotein c-ii deficiency 32.2 APOC2 LPL
19 glucagonoma 31.9 SCT SST
20 pancreas disease 31.6 CCK PRSS1 REG3A SCT SPINK1 SST
21 duodenal ulcer 30.9 CCK SCT SST
22 gallbladder disease 30.5 CCK CFTR SST
23 acute pancreatitis 30.4 APOC2 CCK CPB1 LPL PLA2G2A PNLIP
24 duodenogastric reflux 30.3 CCK SCT SST
25 linitis plastica 30.2 PRSS1 PRSS2
26 diarrhea 30.1 CCK SST TMPRSS15
27 duodenal gastrinoma 30.1 CCK SCT SST
28 duodenal disease 29.9 CCK SCT
29 gastrointestinal system disease 29.6 CCK SCT SST
30 steatorrhea 29.6 APOC2 CCK CFTR PNLIP SCT SST
31 dumping syndrome 29.3 SCT SST
32 pancreatic cancer 12.6
33 pancreatic lipase deficiency 12.4
34 pancreatic neuroendocrine tumor 12.3
35 pancreatic ductal adenocarcinoma 12.3
36 pancreatic ductal carcinoma 12.3
37 melanoma-pancreatic cancer syndrome 12.3
38 neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 12.2
39 renal-hepatic-pancreatic dysplasia 12.2
40 pancreatic cancer 4 12.1
41 pancreatic and cerebellar agenesis 12.1
42 pancreatic acinar cell adenocarcinoma 12.1
43 pancreatic agenesis 2 12.1
44 pancreatic serous cystadenoma 12.1
45 exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis 12.1
46 renal-hepatic-pancreatic dysplasia 2 12.1
47 pancreatic cancer 1 12.0
48 pancreatic cancer 3 12.0
49 pancreatic cancer 2 12.0
50 pancreatic agenesis 12.0

Graphical network of the top 20 diseases related to Pancreatitis:



Diseases related to Pancreatitis
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Symptoms & Phenotypes for Pancreatitis

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UMLS symptoms related to Pancreatitis:


abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, gastrointestinal gas

GenomeRNAi Phenotypes related to Pancreatitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00240-S-1 10 SST
2 Decreased viability GR00381-A-1 10 SCT
3 Decreased viability GR00402-S-2 10 CFTR CPA1 CPB1 CTRC LPL PLA2G2A
4 no effect GR00402-S-1 9.62 APOC2 CASR CCK CFTR CPA1 CPB1
Sources

Drugs & Therapeutics for Pancreatitis

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Drugs for Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 478)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Menthol Approved Phase 4,Not Applicable 2216-51-5 16666
2
Meropenem Approved, Investigational Phase 4,Phase 1,Phase 2 119478-56-7 64778 441130
3
Clonidine Approved Phase 4 4205-90-7 2803
4
Ketorolac Approved Phase 4,Phase 2,Phase 3 74103-06-3, 66635-83-4 3826
5
Tramadol Approved, Investigational Phase 4,Phase 2,Phase 3 27203-92-5 33741
6
Cefoperazone Approved, Investigational Phase 4 62893-19-0 44185
7
Diclofenac Approved, Vet_approved Phase 4,Phase 1,Not Applicable 15307-86-5 3033
8
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 22916-47-8 4189
9
Midazolam Approved, Illicit Phase 4,Phase 2,Phase 3 59467-70-8 4192
10
Metronidazole Approved Phase 4 443-48-1 4173
11
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
12
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
13
Acetaminophen Approved Phase 4,Phase 3,Not Applicable 103-90-2 1983
14
Ropivacaine Approved Phase 4,Phase 2,Phase 3,Phase 1 84057-95-4 71273 175805
15
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
16
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
17
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
18
Indomethacin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 53-86-1 3715
19
Ethanol Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 64-17-5 702
20
Epinephrine Approved, Vet_approved Phase 4,Not Applicable 51-43-4 5816
21
Secretin Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable 108153-74-8
22
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
23
Pancrelipase Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 53608-75-6
24 Pinaverium Approved Phase 4 59995-65-2
25
Somatostatin Approved, Investigational Phase 4,Phase 3,Not Applicable 38916-34-6, 51110-01-1 53481605
26
Racepinephrine Approved Phase 4,Not Applicable 329-65-7 838
27 Nefopam Approved, Investigational Phase 4 13669-70-0
28
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 7440-66-6 23994
29
Etomidate Approved Phase 4 33125-97-2 36339 667484
30
Cilastatin Approved, Investigational Phase 4 82009-34-5 5280454 6435415
31
Pioglitazone Approved, Investigational Phase 4,Phase 3,Phase 2 111025-46-8 4829
32
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 657-24-9 14219 4091
33
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
34
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560
35
Glycerol Approved, Investigational Phase 4,Phase 3 56-81-5 753
36
Voriconazole Approved, Investigational Phase 4 137234-62-9 71616
37
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
38
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 2078-54-8 4943
39
Meperidine Approved Phase 4 57-42-1 4058
40
Ceftazidime Approved Phase 4 78439-06-2, 72558-82-8 5481173
41
Anidulafungin Approved, Investigational Phase 4 166663-25-8 166548
42
Prednisone Approved, Vet_approved Phase 4,Phase 1,Not Applicable 53-03-2 5865
43
Protein C Approved Phase 4,Phase 1,Phase 2
44
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
45
Acetylcholine Approved Phase 4 51-84-3 187
46
Lorazepam Approved Phase 4,Phase 2 846-49-1 3958
47
Etanercept Approved, Investigational Phase 4 185243-69-0
48
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
49
Leflunomide Approved, Investigational Phase 4 75706-12-6 3899
50
Azathioprine Approved Phase 4 446-86-6 2265

Interventional clinical trials:

(show top 50) (show all 645)
# Name Status NCT ID Phase Drugs
1 Comparative Study About the Impact of Two Oil Emulsions Administered Intravenously on Severe Acute Pancreatitis Unknown status NCT01376817 Phase 4 Fat emulsion with MCT, LCT, olive oil and omega 3 fatty acids;Fat emulsion with MCT and LCT
2 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
3 Epinephrine Sprayed on the Papilla for the Prevention of Post-ERCP Pancreatitis Unknown status NCT02839356 Phase 4 epinephrine;normal saline
4 Multi-center Clinical Study of Early Antibios of Severe Acute Pancreatitis Unknown status NCT01992198 Phase 4 cefoperazone + metronidazole;Somatostatin;Meropenem
5 Dexmedetomidine Hydrochloride in the Prevention of Organ Failure Following Severe Acute Pancreatitis Unknown status NCT02691598 Phase 4 Infusion
6 Prophylactic Pancreatic Duct Stent Placement After ESP of Major Papillary Tumors; Prospective, Randomized Study Unknown status NCT01737463 Phase 4
7 Pinaverium Bromide in Post-cholecystectomy Sphincter of Oddi Dysfunction Unknown status NCT02833103 Phase 4 Danshu Capsules;Pinaverium Bromide
8 Steroids in the Postoperative Transient Hypoparathyroidism Total Thyroidectomy Unknown status NCT02652884 Phase 4 phosphate and betamethasone acetate, 2 mL.;saline 0.9% NaCl
9 Uncovered Self-expandable Metal Stent Versus Double Layer Plastic Stent for Malignant Hilar Stricture Unknown status NCT01125865 Phase 4
10 Laparo-endoscopic Single Site (LESS) Cholecystectomy Versus Standard LAP-CHOLE Unknown status NCT01339325 Phase 4
11 Timing of Indomethacin Administration for the Prevention of Post-ERCP Pancreatitis (PEP) Completed NCT02111707 Phase 4 Rectal indomethacin 100mg one time before or after ERCP
12 Imipenem Prophylaxis in Patients With Acute Pancreatitis Completed NCT02897206 Phase 4 Imipenem;Placebo
13 Evaluation of the Digestive and Metabolic Utilisation of Dietary Protein in Patients With Chronic Pancreatitis Completed NCT00957151 Phase 4 Creon
14 Evaluation of Pancreatic Tissue Penetration of Meronem® in the Prophylaxis of Septic Complications in Severe Pancreatitis Completed NCT00318994 Phase 4 Meropenem
15 Enteral Nutrition in Acute Pancreatitis Completed NCT01965873 Phase 4
16 Early Enteral Nutrition for Severe Acute Pancreatitis Completed NCT00995098 Phase 4
17 Activated Protein C in Severe Acute Pancreatitis Completed NCT01017107 Phase 4 Activated protein C
18 Post ERCP Pancreatitis Prevention in Average Risk Patients Completed NCT01784445 Phase 4 Ceftazidime
19 Acute Pancreatitis and Acute Fluid Collections Completed NCT00786929 Phase 4 Conservative treatment
20 Prospective Study of Efficacy of Intra-muscular Vitamin D3 in Tropical Calcific Pancreatitis Completed NCT00956839 Phase 4 Vitamin D3 (Cholecalciferol)
21 The Correlations Between Early Enteral Nutrition and Intra-abdominal Pressure in Severe Acute Pancreatitis Completed NCT01507766 Phase 4 early enteral nutrition;Delayed enteral nutrition
22 A Study to Determine if Antibiotics Prevent Infection in the Pancreas of Patients Where Part of the Pancreas Has Died Completed NCT00061438 Phase 4 meropenem
23 Dexmedetomidine Versus Placebo in Endoscopic Retrograde Cholangiopancreatography (ERCP) Sedation Completed NCT01070680 Phase 4 Precedex;sodium chlorid 0,9%
24 Enzyme Suppletion in Exocrine Pancreatic Dysfunction Completed NCT01430234 Phase 4 Panzytrat 25.000 FIP-E units of Lipase
25 A Trial of 0.025 Wire Guided Cannulation Versus Current Practice 0.035 Wire Guided Cannulation Completed NCT01408264 Phase 4
26 Sitagliptin Therapy to Improve Outcomes After Islet Autotransplant Completed NCT01186562 Phase 4 Sitagliptin;Placebo
27 Assess the Effect of Erythromycin on the Rate of Success in Placement of a Self-propelled Feeding Tube Completed NCT00999232 Phase 4 Erythromycin;Placebo
28 Prospective Study of Celiac Block Injection: 1 vs. 2 Completed NCT00583479 Phase 4
29 DGT Versus TPS in Patients With Initial PD Cannulation by Chance; Prospective Multi-center Study Completed NCT01744847 Phase 4
30 Balloon Catheter vs. Basket Catheter for Endoscopic Bile Duct Stone Extraction Completed NCT02909595 Phase 4
31 UDCA for Symptomatic Gallstone Disease Completed NCT00161083 Phase 4 ursodeoxycholic acid
32 Nutritional and Metabolic Evaluation of a Tube Feeding Immune Enhancing Diet in ICU Patients Completed NCT00560157 Phase 4
33 Etomidate vs. Midazolam for Sedation During ERCP Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
34 Biliary Metal Stent Study: Metal Stents for Management of Distal Malignant Biliary Obstruction Completed NCT00280709 Phase 4
35 Steroids in Fulminant Hepatic Failure in the Pediatric Age Group Completed NCT02375867 Phase 4 prednisolone;methylprednisolone
36 To Study the Effects of Lipid Emulsion on Hemodynamics in Organophosphate Compound Poisoning Completed NCT03564574 Phase 4
37 Covered vs. Uncovered SEMS for Occluded Biliary Metal Stents Completed NCT01315522 Phase 4
38 Application of Somatostatin for Advanced Gastric Cancer After D2 Lymph Node Dissection Completed NCT01914692 Phase 4 Somatostatin
39 This Is An Open-Label, Non-Comparative Study Designed To Evaluate A Short Course Of IV Anidulafungin, Followed Optionally By Oral Voriconazole, For The Treatment Of Candidemia And Invasive Candidiasis Completed NCT00548262 Phase 4 Anidulafungin;Voriconazole
40 Long-Term Growth and Skeletal Effects of Early Growth Hormone Treatment in Turner Syndrome Completed NCT00266656 Phase 4 Humatrope
41 Effect of Early Nutritional Therapy on Frailty, Functional Outcomes and Recovery of Undernourished Medical Inpatients Trial Completed NCT02517476 Phase 4
42 Thiopurine Induced Pancreatitis in IBD Patients Recruiting NCT02281799 Phase 4 Azathioprine
43 Rectal Indomethacin to Prevent Post ESWL-pancreatitis Recruiting NCT02797067 Phase 4 indomethacin suppository;glycerin suppository
44 Treatment of Acute Pancreatitis With Ketorolac Recruiting NCT02885441 Phase 4 Ketorolac;Placebo
45 WallFlex Biliary Fully Covered (FC) Chronic Pancreatitis Study Recruiting NCT01543256 Phase 4
46 Anti-inflammatory Therapy to Improve Outcomes After TPIAT Recruiting NCT02713997 Phase 4 etanercept;Alpha 1-Antitrypsin
47 Early Oral Versus Enteral Nutrition After Pancreatoduodenectomy Recruiting NCT01642875 Phase 4
48 The Effect of Application of TachoSil® in Pancreatoduodenectomy Recruiting NCT03269955 Phase 4 Fibrinogen/thrombin-coated collagen patch
49 Intraductal Secretin Stimulation Test: What Is the Proper Collection Time? Recruiting NCT03263481 Phase 4 Human Secretin for injection 16 mcg
50 Leflunomide for Maintenance of Remission in IgG4 Related Disease Recruiting NCT02703194 Phase 4 Prednisone;Leflunomide

Search NIH Clinical Center for Pancreatitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: pancreatitis

Sources

Genetic Tests for Pancreatitis

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Genetic tests related to Pancreatitis:

# Genetic test Affiliating Genes
1 Pancreatitis 29
Sources

Anatomical Context for Pancreatitis

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MalaCards organs/tissues related to Pancreatitis:

41
Pancreatic Islet, Pancreas, Liver, Testes, Endothelial, Lung, T Cells
Sources

Publications for Pancreatitis

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Articles related to Pancreatitis:

(show top 50) (show all 20055)
# Title Authors Year
1
Synergistic Anti-Cancer Effects of AKT and SRC Inhibition in Human Pancreatic Cancer Cells. ( 29978609 )
2018
2
A Tale of Three Tails and a Cystic Lesion: A Rare Cause of Recurrent Acute Pancreatitis. ( 29961770 )
2018
3
Myxedema Coma Following the Administration of Gonadotropin-releasing Hormone Agonist Complicated by Acute Pancreatitis. ( 29877268 )
2018
4
Cerulein-Induced Acute Pancreatitis Affects Sphingomyelin Signaling Pathway in Rats. ( 29939906 )
2018
5
Pancreaticopleural fistula associated with choledocholithiasis: An infrequent complication of acute pancreatitis. ( 29530342 )
2018
6
IL-35 hinders endogenous anti-tumor T cell immunity and responsiveness to immunotherapy in pancreatic cancer. ( 29980536 )
2018
7
MiR-29a, targeting caveolin 2 expression, is responsible for limitation of pancreatic cancer metastasis in patients with normal level of serum CA125. ( 29978477 )
2018
8
Galectin-3 Mediates Tumor Cell-Stroma Interactions by Activating Pancreatic Stellate Cells to Produce Cytokines viaA Integrin Signaling. ( 29274868 )
2018
9
Clinical course of type 1 autoimmune pancreatitis patients without steroid treatment: a Japanese multicenter study of 97 patients. ( 29430861 )
2018
10
Adoptive transfer of CD3<sup>+</sup>T cells and CD4<sup>+</sup>CD44<sup>high</sup>memory T cells induces autoimmune pancreatitis in MRL/MpJ mice. ( 29383850 )
2018
11
Urgent endoscopic retrograde cholangiopancreatography is not superior to early ERCP in acute biliary pancreatitis with biliary obstruction without cholangitis. ( 29401491 )
2018
12
Selective identification of somatic mutations in pancreatic cancer cells through a combination of next-generation sequencing of plasma DNA using molecular barcodes and a bioinformatic variant filter. ( 29451897 )
2018
13
Hepatobiliary and Pancreatic: Pancreatic cancer with elevated serum IgG4 level due to multiple myeloma mimicking localized autoimmune pancreatitis. ( 29761833 )
2018
14
Secondary Hypertriglyceridemia Causing Recurrent Acute Pancreatitis with Normal Pancreatic Enzymes. ( 29910554 )
2018
15
3F-Box protein 32 degrades ataxia telangiectasia and Rad3-related and regulates DNA damage response induced by gemcitabine in pancreatic cancer. ( 29805624 )
2018
16
Prevalence of inflammatory bowel disease in alcoholic, non-alcoholic and autoimmune pancreatitis. ( 29734447 )
2018
17
Recurrent Acute Pancreatitis in Children: Do not forget the &amp;quot;Worms&amp;quot;. ( 29095350 )
2018
18
Circulating Tumor Cells Predict Occult Metastatic Disease and Prognosis in Pancreatic Cancer. ( 29442211 )
2018
19
A case of gastric wall implantation caused by EUS-FNA 22 months after pancreatic cancer resection. ( 29451172 )
2018
20
Diagnosis and treatment of autoimmune pancreatitis. ( 29901516 )
2018
21
Pathologic Evaluation of Surgical Margins in Pancreatic Cancer Specimens Using Color Coding With Tissue Marking Dyes. ( 29975353 )
2018
22
Tau ablation in mice leads to pancreatic I^ cell dysfunction and glucose intolerance. ( 29401605 )
2018
23
Obstructive jaundice as primary presentation of a stage IIE Non-Hodgkin lymphoma: A decision making process between advanced lymphoma and locally advanced/metastatic pancreatic adenocarcinoma. ( 29547849 )
2018
24
EUS and confocal endomicroscopic diagnosis of pancreatic acinar cell cystadenoma. ( 29906415 )
2018
25
Abrogation of glutathione peroxidase-1 drives EMT and chemoresistance in pancreatic cancer by activating ROS-mediated Akt/GSK3I^/Snail signaling. ( 29980787 )
2018
26
Risk Factors for Post-ERCP Pancreatitis in High-Risk Patients Receiving Post-procedure Rectal Indomethacin. ( 29980976 )
2018
27
CD36 mediates lipid accumulation in pancreatic beta cells under the duress of glucolipotoxic conditions: Novel roles of lysine deacetylases. ( 29274335 )
2018
28
Cutis laxa, exocrine pancreatic insufficiency and altered cellular metabolomics as additional symptoms in a new patient with ATP6AP1-CDG. ( 29396028 )
2018
29
Transient Exocrine Pancreatic Insufficiency: First Report of an Unrecognized Complication of Cytoreductive Surgery and HIPEC. ( 29599360 )
2018
30
A retroperitoneal mass confirmed as a pancreatic adenosquamous carcinoma by endoscopic ultrasound-guided fine-needle aspiration. ( 29069702 )
2018
31
What Patients Look for When Browsing Online for Pancreatic Cancer: The Bait Behind the Byte. ( 29971463 )
2018
32
LIF Drives Neural Remodeling in Pancreatic Cancer and Offers a New Candidate Biomarker. ( 29269518 )
2018
33
A Surgically Resected Pancreatic Schwannoma with Obstructive Jaundice with Special Reference to Differential Diagnosis from Other Cystic Lesions in the Pancreas. ( 29606941 )
2018
34
Human oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study. ( 27742762 )
2018
35
Gallstone Pancreatitis and Choledocholithiasis: Using Imaging and Laboratory Trends to Predict the Likelihood of Persistent Stones at Cholangiography. ( 29626246 )
2018
36
Weak HIF-1alpha expression indicates poor prognosis in resectable pancreatic ductal adenocarcinoma. ( 29973215 )
2018
37
Acute Pancreatitis and Pancreatic Cancer Risk: A Nationwide Matched-cohort Study in Denmark. ( 29432727 )
2018
38
Why now? Delayed drug-induced pancreatitis due to dapsone for dermatitis herpetiformis. ( 29915658 )
2018
39
Role of palliative resection of the primary pancreatic neuroendocrine tumor in patients with unresectable metastatic liver disease: a systematic review and meta-analysis. ( 29503572 )
2018
40
Hepatobiliary and Pancreatic: Hepatic nodules in a patient with familial adenomatous polyposis and colorectal adenocarcinoma. ( 29284077 )
2018
41
Pancreatic panniculitis: the &amp;quot;bright&amp;quot; side of the moon in solid cancer patients. ( 29301491 )
2018
42
Reply to: Genotype-Phenotype Pancreatic Neuroendocrine Tumor Relationship in Multiple Endocrine Neoplasia Type 1 Patients: A 23 Year Experience at a Single Institution. ( 29859614 )
2018
43
Length of stay overestimates severity of post-ERCP pancreatitis: Is it time to revise the consensus definition? ( 29978003 )
2018
44
Management of acute pancreatitis in the first 72 hours. ( 29957661 )
2018
45
Endoscopic Ultrasound Features of Multiple Endocrine Neoplasia Type 1-Related versus Sporadic Pancreatic Neuroendocrine Tumors: A Single-Center Retrospective Study. ( 29698969 )
2018
46
Acute pancreatitis: ascaris in the pancreatic duct. ( 29452432 )
2018
47
Pancreatic stellate cells reorganize matrix components and lead pancreatic cancer invasion via the function of Endo180. ( 29061505 )
2018
48
Establishment of the First Well-differentiated Human Pancreatic Neuroendocrine Tumor Model. ( 29330294 )
2018
49
Infected necrotising pancreatitis: antibiotic administration remains the first step - Authors' reply. ( 29976468 )
2018
50
Exploring the relationship between nonalcoholic fatty liver disease and pancreatic cancer by computed tomographic survey. ( 29235054 )
2018
Sources

Variations for Pancreatitis

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ClinVar genetic disease variations for Pancreatitis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 TMEM67 NM_153704.5(TMEM67): c.1843T> C (p.Cys615Arg) single nucleotide variant Pathogenic/Likely pathogenic rs201893408 GRCh37 Chromosome 8, 94808198: 94808198
2 TMEM67 NM_153704.5(TMEM67): c.1843T> C (p.Cys615Arg) single nucleotide variant Pathogenic/Likely pathogenic rs201893408 GRCh38 Chromosome 8, 93795970: 93795970
3 CFTR NM_000492.3(CFTR): c.2991G> C (p.Leu997Phe) single nucleotide variant risk factor rs1800111 GRCh37 Chromosome 7, 117250575: 117250575
4 CFTR NM_000492.3(CFTR): c.2991G> C (p.Leu997Phe) single nucleotide variant risk factor rs1800111 GRCh38 Chromosome 7, 117610521: 117610521
5 TMEM67 NM_153704.5(TMEM67): c.1321C> T (p.Arg441Cys) single nucleotide variant Pathogenic/Likely pathogenic rs752362727 GRCh38 Chromosome 8, 93786255: 93786255
6 TMEM67 NM_153704.5(TMEM67): c.1321C> T (p.Arg441Cys) single nucleotide variant Pathogenic/Likely pathogenic rs752362727 GRCh37 Chromosome 8, 94798483: 94798483

Copy number variations for Pancreatitis from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 194974 5 147184338 147191453 Deletion SPINK1 Pancreatitis
2 220321 7 137300000 142800000 Triplication PRSS1 Pancreatitis
3 220322 7 137300000 142800000 Triplication PRSS2 Pancreatitis
4 221070 7 142136892 142140501 Triplication PRSS1 Pancreatitis
5 221298 7 142800000 147500000 Triplication PRSS1 Pancreatitis
Sources

Expression for Pancreatitis

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Search GEO for disease gene expression data for Pancreatitis.
Sources

GO Terms for Pancreatitis

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Cellular components related to Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 APOC2 CCK CPA1 CPB1 CTRC LPL
2 extracellular space GO:0005615 9.47 APOC2 CCK CPA1 CPB1 LPL PLA2G2A
3 very-low-density lipoprotein particle GO:0034361 9.26 APOC2 LPL
4 chylomicron GO:0042627 9.16 APOC2 LPL

Biological processes related to Pancreatitis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.85 CPA1 CPB1 CTRC PRSS1 PRSS2 TMPRSS15
2 triglyceride homeostasis GO:0070328 9.51 APOC2 LPL
3 retinoid metabolic process GO:0001523 9.5 APOC2 LPL PNLIP
4 sperm capacitation GO:0048240 9.49 CFTR SPINK1
5 cobalamin metabolic process GO:0009235 9.48 CTRC PRSS1
6 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.46 LPL PLA2G2A
7 very-low-density lipoprotein particle remodeling GO:0034372 9.43 APOC2 LPL
8 antimicrobial humoral response GO:0019730 9.43 PLA2G2A PRSS2 REG3A
9 chylomicron remodeling GO:0034371 9.4 APOC2 LPL
10 cell wall disruption in other organism GO:0044278 9.16 REG1A REG3A
11 digestion GO:0007586 9.13 PRSS1 PRSS2 SST
12 lipid catabolic process GO:0016042 8.92 APOC2 LPL PLA2G2A PNLIP

Molecular functions related to Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.62 CTRC PRSS1 PRSS2 TMPRSS15
2 hormone activity GO:0005179 9.58 CCK SCT SST
3 serine-type peptidase activity GO:0008236 9.46 CTRC PRSS1 PRSS2 TMPRSS15
4 triglyceride lipase activity GO:0004806 9.43 LPL PNLIP
5 peptidase activity GO:0008233 9.43 CPA1 CPB1 CTRC PRSS1 PRSS2 TMPRSS15
6 peptidoglycan binding GO:0042834 9.37 REG1A REG3A
7 hydrolase activity GO:0016787 9.32 CFTR CPA1 CPB1 CTRC LPL PLA2G2A
8 oligosaccharide binding GO:0070492 9.26 REG1A REG3A
Sources

Sources for Pancreatitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
48