MCID: PNC044
MIFTS: 57

Pancreatitis

Categories: Bone diseases, Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Infectious diseases, Rare diseases
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Aliases & Classifications for Pancreatitis

Summaries for Pancreatitis

MedlinePlus: 41 The pancreas is a large gland behind the stomach and close to the first part of the small intestine. It secretes digestive juices into the small intestine through a tube called the pancreatic duct. The pancreas also releases the hormones insulin and glucagon into the bloodstream. Pancreatitis is inflammation of the pancreas. It happens when digestive enzymes start digesting the pancreas itself. Pancreatitis can be acute or chronic. Either form is serious and can lead to complications. Acute pancreatitis occurs suddenly and usually goes away in a few days with treatment. It is often caused by gallstones. Common symptoms are severe pain in the upper abdomen, nausea, and vomiting. Treatment is usually a few days in the hospital for intravenous (IV) fluids, antibiotics, and medicines to relieve pain. Chronic pancreatitis does not heal or improve. It gets worse over time and leads to permanent damage. The most common cause is heavy alcohol use. Other causes include cystic fibrosis and other inherited disorders, high levels of calcium or fats in the blood, some medicines, and autoimmune conditions. Symptoms include nausea, vomiting, weight loss, and oily stools. Treatment may also be a few days in the hospital for intravenous (IV) fluids, medicines to relieve pain, and nutritional support. After that, you may need to start taking enzymes and eat a special diet. It is also important to not smoke or drink alcohol. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary: Pancreatitis, also known as mumps pancreatitis, is related to pancreatitis, hereditary and autoimmune pancreatitis, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Pancreatitis is REG3A (Regenerating Family Member 3 Alpha), and among its related pathways/superpathways is Gastric acid production. The drugs Somatostatin and Cefoperazone have been mentioned in the context of this disorder. Affiliated tissues include pancreas, small intestine and bone marrow, and related phenotypes are no effect and no effect

Disease Ontology: 11 A pancreas disease that is characterized by inflammation of the pancreas.

GeneReviews: NBK190101

Related Diseases for Pancreatitis

Diseases in the Pancreatitis family:

Pancreatitis, Hereditary Autoimmune Pancreatitis
Acute Pancreatitis Prss1-Related Hereditary Pancreatitis
Autoimmune Pancreatitis Type 2 Autoimmune Pancreatitis Type 1

Diseases related to Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1783)
# Related Disease Score Top Affiliating Genes
1 pancreatitis, hereditary 33.4 SPINK1 SCT REG1A PRSS2 PRSS1 CTRC
2 autoimmune pancreatitis 33.2 SPINK1 SCT PRSS1 CRP CFTR
3 tropical calcific pancreatitis 33.2 SPINK1 PRSS1 CTRC
4 acute pancreatitis 32.9 VMP1 SST SPINK1 SCT REG3A PRSS1
5 acute necrotizing pancreatitis 32.8 SST PNLIP CRP CCK
6 acute hemorrhagic pancreatitis 32.7 SST SPINK1 SCT PNLIP CCK
7 alcoholic pancreatitis 32.7 SPINK1 SCT PRSS1 LPL CTRC CPB1
8 prss1-related hereditary pancreatitis 32.5 SPINK1 PRSS2 PRSS1 CTRC CFTR
9 familial lipoprotein lipase deficiency 32.4 PNLIP LPL APOC2
10 hyperlipoproteinemia, type i 32.3 PNLIP LPL APOC2
11 bile duct cysts 32.2 SPINK1 PRSS1 CTRC
12 mikulicz disease 32.2 SPINK1 CRP
13 pancreatic cancer 32.1 SST SPINK1 SCT REG3A REG1A PRSS1
14 apolipoprotein c-ii deficiency 32.0 LPL APOC2
15 hyperlipoproteinemia, type iv 32.0 LPL APOC2
16 cholangitis 32.0 SST CRP CFTR
17 obstructive jaundice 31.9 SST CRP CCK
18 familial hyperlipidemia 31.8 LPL CRP APOC2
19 nutritional deficiency disease 31.8 SCT CRP CCK
20 cholelithiasis 31.7 SST CRP CCK
21 cholangitis, primary sclerosing 31.6 SCT CRP CFTR
22 exocrine pancreatic insufficiency 31.5 SPINK1 SCT PRSS1 PNLIP CFTR CCK
23 biliary dyskinesia 31.5 SST SPINK1 SCT PRSS1 CFTR CCK
24 duodenal ulcer 31.4 SST SCT CCK
25 duodenal obstruction 31.4 SST SPINK1 PRSS1 CRP CCK
26 cystic fibrosis 31.3 SPINK1 SCT REG3A PRSS1 PNLIP LPL
27 gallbladder disease 31.3 SST CRP CFTR CCK
28 peptic ulcer disease 31.3 SST SCT CRP CCK
29 diarrhea 31.2 SST SCT CFTR CCK
30 gastroparesis 31.2 SST SCT CCK
31 pancreas, annular 31.2 SPINK1 PRSS1 CTRC
32 inflammatory bowel disease 31.1 SST SCT REG3A PLA2G2A CRP CCK
33 diabetes mellitus 31.1 SST SPINK1 SCT REG1A PNLIP LPL
34 intestinal pseudo-obstruction 31.1 SST SPINK1 PRSS1 CFTR
35 neuroendocrine tumor 31.0 SST SCT CCK
36 duodenitis 31.0 SST CRP CCK
37 acalculous cholecystitis 30.9 CRP CCK
38 type 2 diabetes mellitus 30.9 SST SPINK1 SCT PNLIP PLA2G2A LPL
39 constipation 30.8 SST CRP CFTR CCK
40 active peptic ulcer disease 30.8 SST CRP
41 parotitis 30.8 SPINK1 CRP
42 pancreas disease 30.7 SPINK1 SCT REG3A REG1A PNLIP CFTR
43 uremia 30.7 LPL CRP CASR
44 cholecystolithiasis 30.7 SST CRP CCK
45 irritable bowel syndrome 30.7 SST CRP CCK
46 pancreatic steatorrhea 30.7 SCT PRSS1 PNLIP
47 glucose intolerance 30.6 SST LPL CRP
48 gas gangrene 30.5 PLA2G2A CRP CPB1
49 multiple endocrine neoplasia, type i 30.5 SST SCT CASR
50 volvulus of midgut 30.5 CRP CCK

Graphical network of the top 20 diseases related to Pancreatitis:



Diseases related to Pancreatitis

Symptoms & Phenotypes for Pancreatitis

UMLS symptoms related to Pancreatitis:


abdominal pain; constipation; diarrhea; dyspepsia; heartburn; icterus; nausea and vomiting; gastrointestinal gas

GenomeRNAi Phenotypes related to Pancreatitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.2 APOC2 CASR CCK CFTR CPA1 CPB1
2 no effect GR00402-S-2 10.2 APOC2 CASR CCK CFTR CPA1 CPB1

MGI Mouse Phenotypes related to Pancreatitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.89 APOC2 CASR CCK CFTR CPA1 CPB1
2 digestive/alimentary MP:0005381 9.28 CASR CFTR CPA1 CTRC PNLIP SPINK1

Drugs & Therapeutics for Pancreatitis

Drugs for Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 341)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Somatostatin Approved, Investigational Phase 4 38916-34-6, 51110-01-1 53481605 16129706
2
Cefoperazone Approved, Investigational Phase 4 62893-19-0 44185 44187
3
Racepinephrine Approved, Vet_approved Phase 4 51-43-4, 329-65-7 838 5816
4
Acetylcysteine Approved, Investigational Phase 4 616-91-1 581 12035
5
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
6
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
7
Meropenem Approved, Investigational Phase 4 119478-56-7, 96036-03-2 441130
8
Dexmedetomidine Approved, Experimental, Vet_approved Phase 4 86347-14-0, 113775-47-6 68602 5311068
9
Meperidine Approved Phase 4 57-42-1 4058
10
Cilastatin Approved, Investigational Phase 4 82009-34-5 6435415
11
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
12
Glycerin Approved, Investigational Phase 4 56-81-5 753
13
Erythromycin Approved, Investigational, Vet_approved Phase 4 55-31-2, 114-07-8 12560
14
Ceftazidime Approved Phase 4 78439-06-2, 72558-82-8 5481173
15
Etomidate Approved Phase 4 33125-97-2 667484
16
Protein C Approved Phase 4
17
Etanercept Approved, Investigational Phase 4 185243-69-0
18
Indomethacin Approved, Investigational Phase 4 53-86-1 3715
19
Diclofenac Approved, Vet_approved Phase 4 15307-86-5, 15307-79-6 3033
20
Resveratrol Investigational Phase 4 501-36-0 445154
21
Thymalfasin Investigational Phase 4 62304-98-7 16167214 16130571
22
Polygeline Experimental Phase 4 66455-30-9
23 Sulperazone Phase 4
24 Disinfectants Phase 4
25 Soy Bean Phase 4
26 Mydriatics Phase 4
27 Bronchodilator Agents Phase 4
28 Epinephryl borate Phase 4
29 Respiratory System Agents Phase 4
30 Anti-Asthmatic Agents Phase 4
31 Adrenergic beta-Agonists Phase 4
32 Parenteral Nutrition Solutions Phase 4
33 Soybean oil, phospholipid emulsion Phase 4
34 Fat Emulsions, Intravenous Phase 4
35 N-monoacetylcystine Phase 4
36 Expectorants Phase 4
37 Antidotes Phase 4
38 Antiviral Agents Phase 4
39 Protective Agents Phase 4
40 Hormones Phase 4
41 Hormone Antagonists Phase 4
42 Antibiotics, Antitubercular Phase 4
43 Anti-Bacterial Agents Phase 4
44 Psychotropic Drugs Phase 4
45 Anti-Anxiety Agents Phase 4
46
protease inhibitors Phase 4
47 HIV Protease Inhibitors Phase 4
48 Fibrinolytic Agents Phase 4
49 GABA Modulators Phase 4
50 Incretins Phase 4

Interventional clinical trials:

(show top 50) (show all 605)
# Name Status NCT ID Phase Drugs
1 Escalade or Deseacalade Antibiotic Use in Severe Acute Pancreatitis Unknown status NCT01992198 Phase 4 cefoperazone + metronidazole;Somatostatin;Meropenem
2 Dexmedetomidine Hydrochloride in the Prevention of Organ Failure Following Unknown status NCT02691598 Phase 4 Infusion
3 Early Oral Versus Enteral Nutrition After Pancreatoduodenectomy for Periampullary Tumors: a Prospective, Randomized, Controlled Clinical Trial Unknown status NCT01642875 Phase 4
4 Effect Observation Study of COX-2 Inhibitor to Prevent Post-ERCP Pancreatitis Unknown status NCT02964403 Phase 4 Cox-2;Indomethacin
5 Pancreatitis CytoSorbents (CytoSorb®) Inflammatory Cytokine Removal: A Prospective Study. Unknown status NCT03082469 Phase 4
6 Comparative Study About the Impact of Two Oil Emulsions, One of Them Formulated With MCT, LCT, Olive Oil and Omega 3 Fatty Acids Versus Another One Formulated With MCT and LCT, Administered Intravenously on Severe Acute Pancreatitis Clinical Evolution Unknown status NCT01376817 Phase 4 Fat emulsion with MCT, LCT, olive oil and omega 3 fatty acids;Fat emulsion with MCT and LCT
7 Oral Resveratrol Before ERCP Redused Overall Pancreatitis in Patients Undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP): A Multi-center, Single-blinded, Randomized Controlled Trial Unknown status NCT02947932 Phase 4 Resveratrol;Indomethacin
8 Randomized, Controlled, Open-label Trial of Intravenous Intensive Insulin for Severe/Moderate Hypertriglyceridemia Pancreatitis. Unknown status NCT03501680 Phase 4 Insulin
9 Randomized, Controlled, Multicenter Studies of the Effects of Intravenous Administration of Insulin and Plasma Exchange on Triglyceride Levels in Early Stage of Hypertriglyceridemia-induced Pancreatitis Unknown status NCT03342807 Phase 4 Insulin
10 Comparative Evaluation of Standard Prophylaxis Versus Divided-dose NSAIDs or Hybrid NSAID and N-acetylcysteine Therapy for the Prevention of Post-ERCP Pancreatitis Unknown status NCT03708458 Phase 4 indomethacin suppository;N-acetylcysteine (NAC)
11 Epinephrine Sprayed on the Papilla for the Prevention of Post-ERCP Pancreatitis Unknown status NCT02839356 Phase 4 epinephrine;normal saline
12 A Multi-Center, Prospective, Randomized Study Comparing Removable, Self-Expanding Metal Stents to Plastic Stents for the Treatment of Benign Biliary Strictures Secondary to Chronic Pancreatitis Completed NCT01543256 Phase 4
13 Enzyme Substitution in Exocrine Pancreatic Insufficiency; Self Administration Against a Fixed Dose Regimen Completed NCT01430234 Phase 4 Panzytrat 25.000 FIP-E units of Lipase
14 A Prospective Study of Celiac Block Technique: One Injection or Two? Completed NCT00583479 Phase 4
15 Evaluation of the Digestive and Metabolic Utilisation of Dietary Protein in Patients With Chronic Pancreatitis Completed NCT00957151 Phase 4 Creon
16 The Impact of Early Enteral Nutrition on the Clinical Outcomes of Severe Acute Pancreatitis Patients: A Randomized Control Trial Completed NCT00995098 Phase 4
17 Double-blind Randomized Study to Determine the Efficacy of Intramuscular Vitamin D3 Supplementation in Tropical Calcific Pancreatitis Completed NCT00956839 Phase 4 Vitamin D3 (Cholecalciferol)
18 A Multicentre, Randomised, Double-blind, Placebo-controlled, Study on the Use of Prophylactic Meropenem Therapy in Subjects With Severe Acute Necrotizing Pancreatitis Completed NCT00061438 Phase 4 meropenem
19 Thymosin Alpha 1 in the Prevention of Pancreatic Infection Following Acute Necrotizing Pancreatitis Completed NCT02473406 Phase 4 Thymosin Alpha 1;normal saline
20 Imipenem Prophylaxis of Infectious Complications in Patients With Acute Pancreatitis Completed NCT02897206 Phase 4 Imipenem;Placebo
21 Timing of Indomethacin Administration for the Prevention of Post-ERCP Pancreatitis (PEP) Completed NCT02111707 Phase 4 Rectal indomethacin 100mg one time before or after ERCP
22 Randomized Controlled Trial on Sterile Fluid Collections Management in Acute Pancreatitis Completed NCT00786929 Phase 4 Conservative treatment
23 The Correlations Between Early Enteral Nutrition and Intra-abdominal Pressure in Severe Acute Pancreatitis Completed NCT01507766 Phase 4 early enteral nutrition;Delayed enteral nutrition
24 APCAP - Activated Protein C in Severe Acute Pancreatitis: A Double-blind Randomized Human Pilot Trial Completed NCT01017107 Phase 4 Activated protein C
25 Enteral Nutrition for Treatment of Acute Pancreatitis - a Prospective, Randomized Clinical Trial Completed NCT01965873 Phase 4
26 Evaluation of Pancreatic Tissue Penetration of Meronem® in the Prophylaxis of Septic Complications in Severe Pancreatitis Completed NCT00318994 Phase 4 Meropenem
27 Rectally Administered Indomethacin to Prevent Post-ESWL-pancreatitis (RIPEP) Completed NCT02797067 Phase 4 indomethacin suppository;Glycerin Suppository
28 Diclophenac Potassium Versus Ceftazidime for Reduction of Post ERCP Pancreatitis in Average Risk Patients-double Blind, Randomised Controlled Trial Completed NCT01784445 Phase 4 Ceftazidime
29 Etomidate With Meperidine vs Midazolam With Meperidine for Sedation During Endodscopic Retrograde Cholangiopancreatogram (ERCP) Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
30 DGT Versus TPS in Patients With Initial PD Cannulation by Chance; Prospective Randomized Multi-center Study Completed NCT01744847 Phase 4
31 A Prospective Randomised Trial of 0.025 Wire Guided Cannulation Versus Current Practice 0.035 Wire Guided Cannulation Completed NCT01408264 Phase 4
32 A Double-Blind, Randomized, Placebo Controlled Intervention Study to Assess the Impact of Sitagliptin 100 mg/Day for 1 Year on Insulin Independence Following Pancreatectomy and Autoislet Transplantation Completed NCT01186562 Phase 4 Sitagliptin;Placebo
33 Dexmedetomidine vs Placebo in ERCP Sedation.A Randomized Pilot Study Completed NCT01070680 Phase 4 Precedex;sodium chlorid 0,9%
34 Assess the Effect of Erythromycin on the Rate of Success in Placement of a Self-propelled Feeding Tube Completed NCT00999232 Phase 4 Erythromycin;Placebo
35 Nutritional and Metabolic Evaluation of a Tube Feeding Immune Enhancing Diet in ICU Patients Completed NCT00560157 Phase 4
36 A Phase 4 Study to Assess Symptoms of Exocrine Pancreatic Insufficiency in Subjects With Cystic Fibrosis or Chronic Pancreatitis Treated With Creon® (Pancrelipase) With an Alternate Source of Active Pharmaceutical Ingredient Recruiting NCT05069597 Phase 4 CREON
37 Treatment With Balanced Crystalloid Solutions in the Early Phase of Acute Pancreatitis Recruiting NCT04688645 Phase 4 Balanced crystalloid solution;Normal saline
38 Anti-inflammatory Therapy to Improve Outcomes in Patients With Chronic Pancreatitis Undergoing Total Pancreatectomy Islet Autotransplantation Active, not recruiting NCT02713997 Phase 4 etanercept;Alpha 1-Antitrypsin
39 The Use of Intravenous Ketorolac in a Multimodal Approach to Pain Management in Acute Pancreatitis Enrolling by invitation NCT04282200 Phase 4 Ketorolac
40 Comparison of Insulin and Standard Management in Hypertriglyceridemic Acute Pancreatitis in Patients Without Diabetes Not yet recruiting NCT05487833 Phase 4
41 Multicenter, Double-bind, Randomised, Placebo Controlled Study of Ulinastatin in Severe Acute Pancreatitis Suspended NCT01132521 Phase 4 ulinastatin;placebo
42 Intraduodenal Aspiration Study to Assess the Bioavailability of Oral Pancrecarb® Compared to Placebo Control in Patients With Pancreatic Insufficiency Terminated NCT00744250 Phase 4 Pancrelipase
43 A Prospective, Randomized, Controlled Trial of Rectal Indomethacin in the Prevention of Post-ERCP Pancreatitis in High Risk Patients. Terminated NCT00820612 Phase 4 Indomethacin
44 Treatment of Acute Pancreatitis With Ketorolac Terminated NCT02885441 Phase 4 Ketorolac
45 Diclofenac for the Prevention of Post-ERCP Pancreatitis in Higher Risk Patients: A Prospective, Randomized, Double Blind, Placebo Controlled Trial. Terminated NCT00428025 Phase 4 diclofenac;placebo
46 A Phase 4 Open-Label Single-Arm Study To Evaluate The Use Of CREON In Subjects With EPI Due To Etiologies Other Than Cystic Fibrosis, Chronic Pancreatitis, Pancreatectomy, Or Pancreatic Cancer Withdrawn NCT04315311 Phase 4 CREON
47 Thiopurine Induced Pancreatitis in IBD Patients Withdrawn NCT02281799 Phase 4 Azathioprine
48 A Randomized Controlled Trial of IV Ketorolac to Prevent Post-ERCP Pancreatitis Withdrawn NCT02465138 Phase 4 Ketorolac;Placebo
49 Simvastatin in the Prevention of Recurrent Pancreatitis, a Triple Blind, Randomized Controlled Trial Unknown status NCT04021498 Phase 3 Simvastatin 40mg
50 Evaluation of Effect of Integrated Treatment by Traditional Chinese and Western Medicine for Severe Acute Pancreatitis Unknown status NCT00506337 Phase 2, Phase 3 Qingyi granules

Search NIH Clinical Center for Pancreatitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Propantheline
Propantheline Bromide

Genetic Tests for Pancreatitis

Genetic tests related to Pancreatitis:

# Genetic test Affiliating Genes
1 Pancreatitis 28

Anatomical Context for Pancreatitis

Organs/tissues related to Pancreatitis:

MalaCards : Pancreas, Small Intestine, Bone Marrow, Kidney, Liver, Pancreatic Islet, Spinal Cord

Publications for Pancreatitis

Articles related to Pancreatitis:

(show top 50) (show all 30153)
# Title Authors PMID Year
1
The natural history of hereditary pancreatitis: a national series. 53 62 24
18755888 2009
2
Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population: role of serine protease inhibitor Kazal 1type and alcohol. 53 62 24
18680227 2008
3
Prolonged activated partial thromboplastin time predicts poor short-term prognosis in patients with acute pancreatitis: A retrospective cohort study. 62 41
35871496 2022
4
Development and validation of a risk prediction score for the severity of acute hypertriglyceridemic pancreatitis in Chinese patients. 62 41
36156930 2022
5
A nomogram for clinical estimation of acute biliary pancreatitis risk among patients with symptomatic gallstones: A retrospective case-control study. 62 41
35982781 2022
6
Variants That Affect Function of Calcium Channel TRPV6 Are Associated With Early-Onset Chronic Pancreatitis. 62 24
31930989 2020
7
Acute Pancreatitis Task Force on Quality: Development of Quality Indicators for Acute Pancreatitis Management. 62 24
31205135 2019
8
Elastase 3B mutation links to familial pancreatitis with diabetes and pancreatic adenocarcinoma. 62 24
31369399 2019
9
Genetic Risk Score in Diabetes Associated With Chronic Pancreatitis Versus Type 2 Diabetes Mellitus. 62 24
31232720 2019
10
Pancreatitis: TIGAR-O Version 2 Risk/Etiology Checklist With Topic Reviews, Updates, and Use Primers. 62 24
31166201 2019
11
Protease-Sensitive Pancreatic Lipase Variants Are Associated With Early Onset Chronic Pancreatitis. 62 24
30789418 2019
12
Chronic Pancreatitis: Pediatric and Adult Cohorts Show Similarities in Disease Progress Despite Different Risk Factors. 62 24
30897605 2019
13
Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis. 62 24
28754779 2018
14
Guidelines for the Diagnostic Cross Sectional Imaging and Severity Scoring of Chronic Pancreatitis. 62 24
30177434 2018
15
Hereditary Pancreatitis in the United States: Survival and Rates of Pancreatic Cancer. 62 24
30018304 2018
16
Recurrent Acute Pancreatitis: International State-of-the-Science Conference With Recommendations. 62 24
29894415 2018
17
Patient and Disease Characteristics Associated With the Presence of Diabetes Mellitus in Adults With Chronic Pancreatitis in the United States. 62 24
28741615 2017
18
Chronic pancreatitis. 62 24
28880010 2017
19
Guidelines for the understanding and management of pain in chronic pancreatitis. 62 24
28734722 2017
20
Validation of Demographics, Etiology, and Risk Factors for Chronic Pancreatitis in the USA: A Report of the North American Pancreas Study (NAPS) Group. 62 24
28600657 2017
21
Long-term pain relief with optimized medical treatment including antioxidants and step-up interventional therapy in patients with chronic pancreatitis. 62 24
27061119 2017
22
A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis. 62 24
25774637 2015
23
Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study. 62 24
25028398 2015
24
Pancreatitis-diabetes-pancreatic cancer: summary of an NIDDK-NCI workshop. 62 24
24152948 2013
25
Variants in CPA1 are strongly associated with early onset chronic pancreatitis. 62 24
23955596 2013
26
Detection, evaluation and treatment of diabetes mellitus in chronic pancreatitis: recommendations from PancreasFest 2012. 62 24
23890130 2013
27
Variation in the γ-glutamyltransferase 1 gene and risk of chronic pancreatitis. 62 24
23462328 2013
28
Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus. 62 24
23100216 2013
29
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. 62 24
23143602 2012
30
Oxidative stress in chronic pancreatitis: pathophysiological relevance and management. 62 24
21902596 2011
31
ABO blood group and chronic pancreatitis risk in the NAPS2 cohort. 62 24
21792085 2011
32
Quality of life improves for pediatric patients after total pancreatectomy and islet autotransplant for chronic pancreatitis. 62 24
21683160 2011
33
Imaging of acute pancreatitis. 62 24
21785045 2011
34
Use and perceived effectiveness of non-analgesic medical therapies for chronic pancreatitis in the United States. 62 24
21083584 2011
35
Pancrelipase delayed-release capsules (CREON) for exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery: A double-blind randomized trial. 62 24
20502447 2010
36
Therapeutic implications of oxidative stress in acute and chronic pancreatitis. 62 24
20543682 2010
37
Alcohol consumption, cigarette smoking, and the risk of recurrent acute and chronic pancreatitis. 62 24
19506173 2009
38
A randomized controlled trial of antioxidant supplementation for pain relief in patients with chronic pancreatitis. 62 24
18952082 2009
39
Risk of pancreatic adenocarcinoma in patients with hereditary pancreatitis: a national exhaustive series. 62 24
18184119 2008
40
Yoga: a tool for improving the quality of life in chronic pancreatitis. 62 24
17230607 2007
41
Practice guidelines in acute pancreatitis. 62 24
17032204 2006
42
A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis. 62 24
16699518 2006
43
Cigarette smoking accelerates progression of alcoholic chronic pancreatitis. 62 24
15753536 2005
44
Cigarette smoking as a risk factor for pancreatic cancer in patients with hereditary pancreatitis. 62 24
11448279 2001
45
Early prediction of severity in acute pancreatitis by urinary trypsinogen activation peptide: a multicentre study. 62 24
10859041 2000
46
Oxidative stress in acute and chronic pancreatitis. 62 24
7495225 1995
47
Hereditary pancreatitis. 62 24
7698830 1994
48
Cystic fibrosis carriers are at increased risk for a wide range of cystic fibrosis-related conditions. 24
31882447 2020
49
Primer on Precision Medicine for Complex Chronic Disorders. 24
31335357 2019
50
Parental influence on human germline de novo mutations in 1,548 trios from Iceland. 24
28959963 2017

Variations for Pancreatitis

ClinVar genetic disease variations for Pancreatitis:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 TMEM67 NM_153704.6(TMEM67):c.1321C>T (p.Arg441Cys) SNV Likely Pathogenic
217725 rs752362727 GRCh37: 8:94798483-94798483
GRCh38: 8:93786255-93786255
2 TMEM67 NM_153704.6(TMEM67):c.1843T>C (p.Cys615Arg) SNV Likely Pathogenic
1383 rs201893408 GRCh37: 8:94808198-94808198
GRCh38: 8:93795970-93795970
3 CFTR, LOC111674472 NM_000492.4(CFTR):c.2991G>C (p.Leu997Phe) SNV Uncertain Significance
7229 rs1800111 GRCh37: 7:117250575-117250575
GRCh38: 7:117610521-117610521
4 CFTR, CFTR-AS1 NM_000492.4(CFTR):c.1584G>A (p.Glu528=) SNV Not Provided
43576 rs1800095 GRCh37: 7:117199709-117199709
GRCh38: 7:117559655-117559655

Copy number variations for Pancreatitis from CNVD:

6
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 194974 5 147184338 147191453 Deletion SPINK1 Pancreatitis
2 220321 7 137300000 142800000 Triplication PRSS1 Pancreatitis
3 220322 7 137300000 142800000 Triplication PRSS2 Pancreatitis
4 221070 7 142136892 142140501 Triplication PRSS1 Pancreatitis
5 221298 7 142800000 147500000 Triplication PRSS1 Pancreatitis

Expression for Pancreatitis

Search GEO for disease gene expression data for Pancreatitis.

Pathways for Pancreatitis

Pathways related to Pancreatitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.58 SCT CCK

GO Terms for Pancreatitis

Cellular components related to Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.07 SST SPINK1 SCT REG3A REG1A PRSS2
2 extracellular space GO:0005615 9.78 APOC2 CCK CPA1 CPB1 CRP LPL

Biological processes related to Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid catabolic process GO:0016042 9.86 PNLIP PLA2G2A LPL APOC2
2 very-low-density lipoprotein particle remodeling GO:0034372 9.67 LPL APOC2
3 cell wall disruption in another organism GO:0044278 9.62 REG3A REG1A
4 positive regulation of pancreatic juice secretion GO:0090187 9.46 SPINK1 SCT
5 chylomicron remodeling GO:0034371 9.26 LPL APOC2
6 digestion GO:0007586 9.23 SST PRSS2 PRSS1 CCK

Molecular functions related to Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oligosaccharide binding GO:0070492 9.46 REG3A REG1A
2 peptidase activity GO:0008233 9.43 PRSS2 PRSS1 CTRC CPB1 CPA1
3 hydrolase activity GO:0016787 9.23 PRSS2 PRSS1 PNLIP PLA2G2A LPL CTRC

Sources for Pancreatitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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