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MCID: PNC044
MIFTS: 63

Pancreatitis

Categories: Bone diseases, Endocrine diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Pancreatitis

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MalaCards integrated aliases for Pancreatitis:

Name: Pancreatitis 12 24 29 55 6 43 44 15 40 73

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Endocrine diseases Gastrointestinal diseases Bone diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:4989
ICD10 33 K85.9
MeSH 44 D010195
NCIt 50 C3306
SNOMED-CT 68 75694006
UMLS 73 C0030305
Sources

Summaries for Pancreatitis

About this section
MedlinePlus : 43 The pancreas is a large gland behind the stomach and close to the first part of the small intestine. It secretes digestive juices into the small intestine through a tube called the pancreatic duct. The pancreas also releases the hormones insulin and glucagon into the bloodstream. Pancreatitis is inflammation of the pancreas. It happens when digestive enzymes start digesting the pancreas itself. Pancreatitis can be acute or chronic. Either form is serious and can lead to complications. Acute pancreatitis occurs suddenly and usually goes away in a few days with treatment. It is often caused by gallstones. Common symptoms are severe pain in the upper abdomen, nausea, and vomiting. Treatment is usually a few days in the hospital for intravenous (IV) fluids, antibiotics, and medicines to relieve pain. Chronic pancreatitis does not heal or improve. It gets worse over time and leads to permanent damage. The most common cause is heavy alcohol use. Other causes include cystic fibrosis and other inherited disorders, high levels of calcium or fats in the blood, some medicines, and autoimmune conditions. Symptoms include nausea, vomiting, weight loss, and oily stools. Treatment may also be a few days in the hospital for intravenous (IV) fluids, medicines to relieve pain, and nutritional support. After that, you may need to start taking enzymes and eat a special diet. It is also important to not smoke or drink alcohol. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Pancreatitis is related to tropical calcific pancreatitis and pancreatitis, hereditary, and has symptoms including nausea and vomiting, constipation and abdominal pain. An important gene associated with Pancreatitis is TMEM67 (Transmembrane Protein 67), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and Pancreatic secretion. The drugs Indomethacin and Resveratrol have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and testes, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 76 Pancreatitis is a condition characterized by inflammation of the pancreas. The pancreas is a large organ... more...

GeneReviews: NBK190101
Sources

Related Diseases for Pancreatitis

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Diseases in the Pancreatitis family:

Pancreatitis, Hereditary Autoimmune Pancreatitis
Acute Pancreatitis Prss1-Related Hereditary Pancreatitis
Autoimmune Pancreatitis Type 2 Autoimmune Pancreatitis Type 1
Recurrent Acute Pancreatitis

Diseases related to Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1441)
# Related Disease Score Top Affiliating Genes
1 tropical calcific pancreatitis 34.0 CTRC PRSS1 PRSS2 REG1A SPINK1
2 pancreatitis, hereditary 34.0 CASR CFTR CPA1 CTRC PRSS1 PRSS2
3 pancreatic agenesis 1 33.9 CFTR PNLIP SCT SPINK1
4 pancreatic cancer 33.8 CCK PRSS1 SCT SPINK1 SST
5 exocrine pancreatic insufficiency 33.7 CCK CFTR PNLIP SCT SPINK1
6 pancreatic cholera 33.6 CCK SCT SST
7 pancreatic steatorrhea 33.5 CCK PNLIP PRSS1 SCT
8 pancreas adenocarcinoma 33.3 PRSS1 REG3A SST
9 recurrent acute pancreatitis 33.3 CFTR CTRC LPL PRSS1 SCT SPINK1
10 vipoma 33.2 SCT SST
11 alcoholic pancreatitis 33.1 CCK CFTR LPL PRSS1 SCT SPINK1
12 acute pancreatitis 32.7 APOC2 CCK CFTR CPB1 LPL PLA2G2A
13 cystic fibrosis 32.3 CFTR PRSS1 REG3A SCT SPINK1
14 biliary dyskinesia 32.2 CCK SCT
15 duodenal atresia 32.1 CFTR SCT
16 familial lipoprotein lipase deficiency 32.1 APOC2 LPL PNLIP
17 multiple endocrine neoplasia, type i 32.0 CASR SCT SST
18 apolipoprotein c-ii deficiency 31.9 APOC2 LPL
19 pancreas disease 31.6 CCK CFTR PNLIP PRSS1 REG3A SCT
20 insulinomatosis and diabetes mellitus 31.5 SCT SST
21 glucagonoma 31.5 SCT SST
22 duodenal ulcer 30.5 CCK SCT SST
23 steatorrhea 30.2 APOC2 CCK CFTR PNLIP SCT SST
24 diarrhea 30.1 CCK CFTR SST TMPRSS15
25 gallbladder disease 30.0 CCK CFTR SST
26 gastrointestinal system disease 30.0 CCK SCT SST
27 duodenogastric reflux 29.8 CCK SCT SST
28 linitis plastica 29.5 PRSS1 PRSS2
29 duodenal disease 29.3 CCK SCT SST
30 duodenal gastrinoma 29.3 CCK SCT SST
31 dumping syndrome 29.2 SCT SST
32 pancreatic lipase deficiency 12.6
33 autoimmune pancreatitis 12.5
34 pancreatic ductal adenocarcinoma 12.5
35 pancreatic neuroendocrine tumor 12.5
36 pancreatic ductal carcinoma 12.4
37 melanoma-pancreatic cancer syndrome 12.4
38 neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 12.3
39 renal-hepatic-pancreatic dysplasia 12.3
40 pancreatic cancer 4 12.3
41 pancreatic and cerebellar agenesis 12.3
42 pancreatic acinar cell adenocarcinoma 12.2
43 pancreatic agenesis 2 12.2
44 pancreatic serous cystadenoma 12.2
45 exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis 12.2
46 renal-hepatic-pancreatic dysplasia 2 12.2
47 pancreatic adenosquamous carcinoma 12.2
48 pancreatic cancer 1 12.2
49 pancreatic cancer 3 12.2
50 pancreatic cancer 2 12.2

Graphical network of the top 20 diseases related to Pancreatitis:



Diseases related to Pancreatitis
Sources

Symptoms & Phenotypes for Pancreatitis

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UMLS symptoms related to Pancreatitis:


nausea and vomiting, constipation, abdominal pain, diarrhea, icterus, dyspepsia, heartburn, gastrointestinal gas

GenomeRNAi Phenotypes related to Pancreatitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00240-S-1 10 SST
2 Decreased viability GR00381-A-1 10 SCT
3 Decreased viability GR00402-S-2 10 APOC2 CASR CCK CFTR CPA1 CPB1
4 no effect GR00402-S-1 9.62 APOC2 CASR CCK CFTR CPA1 CPB1
Sources

Drugs & Therapeutics for Pancreatitis

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Drugs for Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 499)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Indomethacin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 53-86-1 3715
2
Resveratrol Approved, Experimental, Investigational Phase 4 501-36-0 445154
3 Nefopam Approved, Investigational Phase 4 13669-70-0
4
Tramadol Approved, Investigational Phase 4,Phase 2,Phase 3 27203-92-5 33741
5
Ropivacaine Approved Phase 4,Phase 2,Phase 3,Phase 1 84057-95-4 175805 71273
6
Clonidine Approved Phase 4 4205-90-7 2803
7
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
8
Acetaminophen Approved Phase 4,Phase 3,Not Applicable 103-90-2 1983
9
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Not Applicable 51-43-4 5816
10
Racepinephrine Approved Phase 4,Phase 3,Not Applicable 329-65-7 838
11
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
12
Metronidazole Approved Phase 4 443-48-1 4173
13
Meropenem Approved, Investigational Phase 4,Phase 1,Phase 2 119478-56-7 64778 441130
14
Cefoperazone Approved, Investigational Phase 4 62893-19-0 44185
15
Somatostatin Approved, Investigational Phase 4,Phase 3,Not Applicable 51110-01-1, 38916-34-6 53481605
16
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
17 Pinaverium Approved Phase 4 59995-65-2
18
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
19
Pancrelipase Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 53608-75-6
20
Diclofenac Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 15307-86-5 3033
21
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2 59467-70-8 4192
22
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-24-8 5755
23
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 83-43-2 6741
24
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 302-25-0
25
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Not Applicable 2921-57-5
26
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 22916-47-8 4189
27
Ketorolac Approved Phase 4,Phase 2,Phase 3 66635-83-4, 74103-06-3 3826
28
Secretin Approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable 108153-74-8
29
Ethanol Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 64-17-5 702
30
Cilastatin Approved, Investigational Phase 4 82009-34-5 6435415 5280454
31
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
32
Protein C Approved Phase 4,Phase 1,Phase 2
33
Ceftazidime Approved Phase 4 78439-06-2, 72558-82-8 5481173
34
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 2078-54-8 4943
35
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560
36
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
37
Meperidine Approved Phase 4 57-42-1 4058
38
Etomidate Approved Phase 4 33125-97-2 667484 36339
39
Atropine Approved, Vet_approved Phase 4 51-55-8, 5908-99-6 174174
40
Voriconazole Approved, Investigational Phase 4 137234-62-9 71616
41
Anidulafungin Approved, Investigational Phase 4 166663-25-8 166548
42
Glycerol Approved, Investigational Phase 4,Phase 3 56-81-5 753
43
Thioguanine Approved Phase 4,Not Applicable 154-42-7 2723601
44
Acetylcysteine Approved, Investigational Phase 4,Phase 1,Phase 2 616-91-1 12035
45
Prednisone Approved, Vet_approved Phase 4,Phase 1,Not Applicable 53-03-2 5865
46
Pioglitazone Approved, Investigational Phase 4,Phase 3,Phase 2 111025-46-8 4829
47
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 657-24-9 14219 4091
48
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 7440-66-6
49
Aprepitant Approved, Investigational Phase 4,Not Applicable 170729-80-3 6918365 151165
50
Fosaprepitant Approved Phase 4,Not Applicable 172673-20-0 219090

Interventional clinical trials:

(show top 50) (show all 705)
# Name Status NCT ID Phase Drugs
1 COX-2 Inhibitor to Prevent Post-ERCP Pancreatitis Unknown status NCT02964403 Phase 4 Cox-2;Indomethacin
2 Oral Resveratrol to Prevent Post-ERCP Pancreatitis Unknown status NCT02947932 Phase 4 Resveratrol;Indomethacin
3 Comparative Study About the Impact of Two Oil Emulsions Administered Intravenously on Severe Acute Pancreatitis Unknown status NCT01376817 Phase 4 Fat emulsion with MCT, LCT, olive oil and omega 3 fatty acids;Fat emulsion with MCT and LCT
4 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
5 Epinephrine Sprayed on the Papilla for the Prevention of Post-ERCP Pancreatitis Unknown status NCT02839356 Phase 4 epinephrine;normal saline
6 Multi-center Clinical Study of Early Antibios of Severe Acute Pancreatitis Unknown status NCT01992198 Phase 4 cefoperazone + metronidazole;Somatostatin;Meropenem
7 Dexmedetomidine Hydrochloride in the Prevention of Organ Failure Following Severe Acute Pancreatitis Unknown status NCT02691598 Phase 4 Infusion
8 Prophylactic Pancreatic Duct Stent Placement After ESP of Major Papillary Tumors; Prospective, Randomized Study Unknown status NCT01737463 Phase 4
9 Pinaverium Bromide in Post-cholecystectomy Sphincter of Oddi Dysfunction Unknown status NCT02833103 Phase 4 Danshu Capsules;Pinaverium Bromide
10 Steroids in the Postoperative Transient Hypoparathyroidism Total Thyroidectomy Unknown status NCT02652884 Phase 4 phosphate and betamethasone acetate, 2 mL.;saline 0.9% NaCl
11 Uncovered Self-expandable Metal Stent Versus Double Layer Plastic Stent for Malignant Hilar Stricture Unknown status NCT01125865 Phase 4
12 Laparo-endoscopic Single Site (LESS) Cholecystectomy Versus Standard LAP-CHOLE Unknown status NCT01339325 Phase 4
13 Timing of Indomethacin Administration for the Prevention of Post-ERCP Pancreatitis (PEP) Completed NCT02111707 Phase 4 Rectal indomethacin 100mg one time before or after ERCP
14 Imipenem Prophylaxis in Patients With Acute Pancreatitis Completed NCT02897206 Phase 4 Imipenem;Placebo
15 Evaluation of the Digestive and Metabolic Utilisation of Dietary Protein in Patients With Chronic Pancreatitis Completed NCT00957151 Phase 4 Creon
16 Evaluation of Pancreatic Tissue Penetration of Meronem® in the Prophylaxis of Septic Complications in Severe Pancreatitis Completed NCT00318994 Phase 4 Meropenem
17 Enteral Nutrition in Acute Pancreatitis Completed NCT01965873 Phase 4
18 Early Enteral Nutrition for Severe Acute Pancreatitis Completed NCT00995098 Phase 4
19 Activated Protein C in Severe Acute Pancreatitis Completed NCT01017107 Phase 4 Activated protein C
20 Post ERCP Pancreatitis Prevention in Average Risk Patients Completed NCT01784445 Phase 4 Ceftazidime
21 Acute Pancreatitis and Acute Fluid Collections Completed NCT00786929 Phase 4 Conservative treatment
22 Prospective Study of Efficacy of Intra-muscular Vitamin D3 in Tropical Calcific Pancreatitis Completed NCT00956839 Phase 4 Vitamin D3 (Cholecalciferol)
23 The Correlations Between Early Enteral Nutrition and Intra-abdominal Pressure in Severe Acute Pancreatitis Completed NCT01507766 Phase 4 early enteral nutrition;Delayed enteral nutrition
24 A Study to Determine if Antibiotics Prevent Infection in the Pancreas of Patients Where Part of the Pancreas Has Died Completed NCT00061438 Phase 4 meropenem
25 Dexmedetomidine Versus Placebo in Endoscopic Retrograde Cholangiopancreatography (ERCP) Sedation Completed NCT01070680 Phase 4 Precedex;sodium chlorid 0,9%
26 Enzyme Suppletion in Exocrine Pancreatic Dysfunction Completed NCT01430234 Phase 4 Panzytrat 25.000 FIP-E units of Lipase
27 A Trial of 0.025 Wire Guided Cannulation Versus Current Practice 0.035 Wire Guided Cannulation Completed NCT01408264 Phase 4
28 Sitagliptin Therapy to Improve Outcomes After Islet Autotransplant Completed NCT01186562 Phase 4 Sitagliptin;Placebo
29 Assess the Effect of Erythromycin on the Rate of Success in Placement of a Self-propelled Feeding Tube Completed NCT00999232 Phase 4 Erythromycin;Placebo
30 Prospective Study of Celiac Block Injection: 1 vs. 2 Completed NCT00583479 Phase 4
31 DGT Versus TPS in Patients With Initial PD Cannulation by Chance; Prospective Multi-center Study Completed NCT01744847 Phase 4
32 Balloon Catheter vs. Basket Catheter for Endoscopic Bile Duct Stone Extraction Completed NCT02909595 Phase 4
33 UDCA for Symptomatic Gallstone Disease Completed NCT00161083 Phase 4 ursodeoxycholic acid
34 Nutritional and Metabolic Evaluation of a Tube Feeding Immune Enhancing Diet in ICU Patients Completed NCT00560157 Phase 4
35 Etomidate vs. Midazolam for Sedation During ERCP Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
36 Biliary Metal Stent Study: Metal Stents for Management of Distal Malignant Biliary Obstruction Completed NCT00280709 Phase 4
37 To Study the Effects of Lipid Emulsion on Hemodynamics in Organophosphate Compound Poisoning Completed NCT03564574 Phase 4
38 Covered vs. Uncovered SEMS for Occluded Biliary Metal Stents Completed NCT01315522 Phase 4
39 Steroids in Fulminant Hepatitis A in the Pediatric Age Group Completed NCT02375867 Phase 4 prednisolone;methylprednisolone
40 Application of Somatostatin for Advanced Gastric Cancer After D2 Lymph Node Dissection Completed NCT01914692 Phase 4 Somatostatin
41 This Is An Open-Label, Non-Comparative Study Designed To Evaluate A Short Course Of IV Anidulafungin, Followed Optionally By Oral Voriconazole, For The Treatment Of Candidemia And Invasive Candidiasis Completed NCT00548262 Phase 4 Anidulafungin;Voriconazole
42 Long-Term Growth and Skeletal Effects of Early Growth Hormone Treatment in Turner Syndrome Completed NCT00266656 Phase 4 Humatrope
43 Effect of Early Nutritional Therapy on Frailty, Functional Outcomes and Recovery of Undernourished Medical Inpatients Trial Completed NCT02517476 Phase 4
44 Rectal Indomethacin to Prevent Post ESWL-pancreatitis Recruiting NCT02797067 Phase 4 indomethacin suppository;Glycerin Suppository
45 Thiopurine Induced Pancreatitis in IBD Patients Recruiting NCT02281799 Phase 4 Azathioprine
46 Pharmacological Prophylaxis of Post- Endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis Recruiting NCT03708458 Phase 4 indomethacin suppository;N-acetylcysteine (NAC)
47 Treatment of Acute Pancreatitis With Ketorolac Recruiting NCT02885441 Phase 4 Ketorolac;Placebo
48 Anti-inflammatory Therapy to Improve Outcomes After TPIAT Recruiting NCT02713997 Phase 4 etanercept;Alpha 1-Antitrypsin
49 Early Oral Versus Enteral Nutrition After Pancreatoduodenectomy Recruiting NCT01642875 Phase 4
50 The Effect of Application of TachoSil® in Pancreatoduodenectomy Recruiting NCT03269955 Phase 4 Fibrinogen/thrombin-coated collagen patch

Search NIH Clinical Center for Pancreatitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: pancreatitis

Sources

Genetic Tests for Pancreatitis

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Genetic tests related to Pancreatitis:

# Genetic test Affiliating Genes
1 Pancreatitis 29
Sources

Anatomical Context for Pancreatitis

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MalaCards organs/tissues related to Pancreatitis:

41
Pancreas, Liver, Testes, Lung, Kidney, Neutrophil, Bone
Sources

Publications for Pancreatitis

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Articles related to Pancreatitis:

(show top 50) (show all 7019)
# Title Authors Year
1
Corrigendum to "Pretreatment with obestatin reduces the severity of ischemia/reperfusion-induced acute pancreatitis in rats" [Eur. J. Pharmacol. 760 (2015) 113-121]. ( 30554633 )
2019
2
Hypertriglyceridemia-Associated Drug-Induced Acute Pancreatitis. ( 30531242 )
2019
3
Effect of Early Abdominal Paracentesis Drainage on the Injury of Intestinal Mucosa and Intestinal Microcirculation in Severe Acute Pancreatitis Rats. ( 30531248 )
2019
4
Pseudohyponatremia in Hypertriglyceridemia-Induced Acute Pancreatitis: A Tool for Diagnosis Rather Than Merely a Laboratory Error? ( 30540682 )
2019
5
Inhibiting role of rosiglitazone in the regulation of inflammatory response and protective effects for severe acute pancreatitis in mice. ( 30206968 )
2019
6
microRNA-542-5p protects against acute lung injury in mice with severe acute pancreatitis by suppressing the mitogen-activated protein kinase signaling pathway through the negative regulation of P21-activated kinase 1. ( 30216510 )
2019
7
Insulin-dependent diabetes: A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia. ( 30216644 )
2019
8
Risk Factors for Pancreatic Stone Formation in Type 1 Autoimmune Pancreatitis: A Long-term Japanese Multicenter Analysis of 624 Patients. ( 30540679 )
2019
9
Evaluation of a Mixed Meal Test for Diagnosis and Characterization of PancrEaTogEniC DiabeTes Secondary to Pancreatic Cancer and Chronic Pancreatitis: Rationale and Methodology for the DETECT Study From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer: Erratum. ( 30531249 )
2019
10
The Management of Chronic Pancreatitis. ( 30466672 )
2019
11
Day of Hospital Admission and Effect on Outcomes: The Weekend Effect in Acute Gallstone Pancreatitis. ( 30502247 )
2019
12
β-Cell Dedifferentiation in Patients With T2D With Adequate Glucose Control and Nondiabetic Chronic Pancreatitis. ( 30085195 )
2019
13
A Tale of Three Tails and a Cystic Lesion: A Rare Cause of Recurrent Acute Pancreatitis. ( 29961770 )
2018
14
Myxedema Coma Following the Administration of Gonadotropin-releasing Hormone Agonist Complicated by Acute Pancreatitis. ( 29877268 )
2018
15
Cerulein-Induced Acute Pancreatitis Affects Sphingomyelin Signaling Pathway in Rats. ( 29939906 )
2018
16
Pancreaticopleural fistula associated with choledocholithiasis: An infrequent complication of acute pancreatitis. ( 29530342 )
2018
17
Clinical course of type 1 autoimmune pancreatitis patients without steroid treatment: a Japanese multicenter study of 97 patients. ( 29430861 )
2018
18
Adoptive transfer of CD3<sup>+</sup>T cells and CD4<sup>+</sup>CD44<sup>high</sup>memory T cells induces autoimmune pancreatitis in MRL/MpJ mice. ( 29383850 )
2018
19
Urgent endoscopic retrograde cholangiopancreatography is not superior to early ERCP in acute biliary pancreatitis with biliary obstruction without cholangitis. ( 29401491 )
2018
20
Hepatobiliary and Pancreatic: Pancreatic cancer with elevated serum IgG4 level due to multiple myeloma mimicking localized autoimmune pancreatitis. ( 29761833 )
2018
21
Secondary Hypertriglyceridemia Causing Recurrent Acute Pancreatitis with Normal Pancreatic Enzymes. ( 29910554 )
2018
22
Prevalence of inflammatory bowel disease in alcoholic, non-alcoholic and autoimmune pancreatitis. ( 29734447 )
2018
23
Recurrent Acute Pancreatitis in Children: Do not forget the &amp;quot;Worms&amp;quot;. ( 29095350 )
2018
24
Diagnosis and treatment of autoimmune pancreatitis. ( 29901516 )
2018
25
Risk Factors for Post-ERCP Pancreatitis in High-Risk Patients Receiving Post-procedure Rectal Indomethacin. ( 29980976 )
2018
26
Gallstone Pancreatitis and Choledocholithiasis: Using Imaging and Laboratory Trends to Predict the Likelihood of Persistent Stones at Cholangiography. ( 29626246 )
2018
27
Acute Pancreatitis and Pancreatic Cancer Risk: A Nationwide Matched-cohort Study in Denmark. ( 29432727 )
2018
28
Why now? Delayed drug-induced pancreatitis due to dapsone for dermatitis herpetiformis. ( 29915658 )
2018
29
Length of stay overestimates severity of post-ERCP pancreatitis: Is it time to revise the consensus definition? ( 29978003 )
2018
30
Management of acute pancreatitis in the first 72 hours. ( 29957661 )
2018
31
Acute pancreatitis: ascaris in the pancreatic duct. ( 29452432 )
2018
32
Infected necrotising pancreatitis: antibiotic administration remains the first step - Authors' reply. ( 29976468 )
2018
33
Comparison of clinical characteristics of radiological forms of autoimmune pancreatitis. ( 29843984 )
2018
34
Focal Autoimmune Pancreatitis Mimicking Pancreatic Cancer on FDG PET/CT Imaging. ( 29189377 )
2018
35
Intraductal tubulopapillary neoplasm of the pancreas presenting as recurrent acute pancreatitis: A case report. ( 29906691 )
2018
36
Cav 1.2 and Cav 2.2 expression is regulated by different endogenous ghrelin levels in pancreatic acinar cells during acute pancreatitis. ( 29436604 )
2018
37
Therapeutic effect of Bifidobacterium combined with early enteral nutrition in the treatment of severe acute pancreatitis: a pilot study. ( 29949178 )
2018
38
Trimethoprim-sulfamethoxazole induces acute pancreatitis associated with drug-specific cytotoxic T lymphocytes. ( 29940316 )
2018
39
Pediatric case of generalized pustular psoriasis developing acute pancreatitis. ( 29655246 )
2018
40
Pathophysiology and nursing management of acute pancreatitis. ( 29952150 )
2018
41
Myths and realities about alcohol and smoking in chronic pancreatitis. ( 29965868 )
2018
42
Response to the Letter by Poddighe et al. regarding our manuscript &amp;quot;Basophils activated via TLR signaling may contribute to pathophysiology of type 1 autoimmune pancreatitis&amp;quot;. ( 29693194 )
2018
43
Successful management of necrotizing pancreatitis in mixed malaria and review of literature. ( 29930900 )
2018
44
Safe and Effective Triglyceride-Lowering Therapy for Hypertriglyceridemia Associated Pancreatitis: Insulin Mono-therapy in a Non-Diabetic Patient. ( 29439301 )
2018
45
Comparison of diagnostic performance between CT and MRI in differentiating non-diffuse-type autoimmune pancreatitis from pancreatic ductal adenocarcinoma. ( 29948075 )
2018
46
Conservative management of acute calculous cholecystitis complicated by pancreatitis in an elderly woman: A case report. ( 29924043 )
2018
47
Monitoring and predicting disease activity in autoimmune pancreatitis with the M-ANNHEIM-AiP-Activity-Score. ( 29158146 )
2018
48
Protective effect of methylsulfonylmethane in caerulein-induced acute pancreatitis and associated lung injury in mice. ( 29971769 )
2018
49
Recommendations for Diagnosis and Management of Autoimmune Pancreatitis in Childhood: Consensus from INSPPIRE. ( 29746340 )
2018
50
Colopancreatic Fistula: An Uncommon Complication of Recurrent Acute Pancreatitis. ( 29785309 )
2018
Sources

Variations for Pancreatitis

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ClinVar genetic disease variations for Pancreatitis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 TMEM67 NM_153704.5(TMEM67): c.1843T> C (p.Cys615Arg) single nucleotide variant Pathogenic/Likely pathogenic rs201893408 GRCh37 Chromosome 8, 94808198: 94808198
2 TMEM67 NM_153704.5(TMEM67): c.1843T> C (p.Cys615Arg) single nucleotide variant Pathogenic/Likely pathogenic rs201893408 GRCh38 Chromosome 8, 93795970: 93795970
3 CFTR NM_000492.3(CFTR): c.1523T> G (p.Phe508Cys) single nucleotide variant Conflicting interpretations of pathogenicity rs74571530 GRCh37 Chromosome 7, 117199648: 117199648
4 CFTR NM_000492.3(CFTR): c.1523T> G (p.Phe508Cys) single nucleotide variant Conflicting interpretations of pathogenicity rs74571530 GRCh38 Chromosome 7, 117559594: 117559594
5 CFTR NM_000492.3(CFTR): c.2991G> C (p.Leu997Phe) single nucleotide variant risk factor rs1800111 GRCh37 Chromosome 7, 117250575: 117250575
6 CFTR NM_000492.3(CFTR): c.2991G> C (p.Leu997Phe) single nucleotide variant risk factor rs1800111 GRCh38 Chromosome 7, 117610521: 117610521
7 TMEM67 NM_153704.5(TMEM67): c.1321C> T (p.Arg441Cys) single nucleotide variant Pathogenic/Likely pathogenic rs752362727 GRCh38 Chromosome 8, 93786255: 93786255
8 TMEM67 NM_153704.5(TMEM67): c.1321C> T (p.Arg441Cys) single nucleotide variant Pathogenic/Likely pathogenic rs752362727 GRCh37 Chromosome 8, 94798483: 94798483

Copy number variations for Pancreatitis from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 194974 5 147184338 147191453 Deletion SPINK1 Pancreatitis
2 220321 7 137300000 142800000 Triplication PRSS1 Pancreatitis
3 220322 7 137300000 142800000 Triplication PRSS2 Pancreatitis
4 221070 7 142136892 142140501 Triplication PRSS1 Pancreatitis
5 221298 7 142800000 147500000 Triplication PRSS1 Pancreatitis
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Expression for Pancreatitis

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Search GEO for disease gene expression data for Pancreatitis.
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GO Terms for Pancreatitis

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Cellular components related to Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.83 APOC2 CCK CPA1 CPB1 CTRC LPL
2 extracellular space GO:0005615 9.47 APOC2 CCK CPA1 CPB1 LPL PLA2G2A
3 very-low-density lipoprotein particle GO:0034361 9.26 APOC2 LPL
4 chylomicron GO:0042627 9.16 APOC2 LPL

Biological processes related to Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.8 CPA1 CPB1 CTRC PRSS1 PRSS2 TMPRSS15
2 sperm capacitation GO:0048240 9.48 CFTR SPINK1
3 cobalamin metabolic process GO:0009235 9.46 CTRC PRSS1
4 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.43 LPL PLA2G2A
5 antimicrobial humoral response GO:0019730 9.43 PLA2G2A PRSS2 REG3A
6 very-low-density lipoprotein particle remodeling GO:0034372 9.4 APOC2 LPL
7 chylomicron remodeling GO:0034371 9.37 APOC2 LPL
8 lipid catabolic process GO:0016042 9.26 APOC2 LPL PLA2G2A PNLIP
9 cell wall disruption in other organism GO:0044278 9.16 REG1A REG3A
10 digestion GO:0007586 8.92 CCK PRSS1 PRSS2 SST

Molecular functions related to Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.62 CTRC PRSS1 PRSS2 TMPRSS15
2 hormone activity GO:0005179 9.54 CCK SCT SST
3 serine-type peptidase activity GO:0008236 9.46 CTRC PRSS1 PRSS2 TMPRSS15
4 triglyceride lipase activity GO:0004806 9.43 LPL PNLIP
5 peptidase activity GO:0008233 9.43 CPA1 CPB1 CTRC PRSS1 PRSS2 TMPRSS15
6 peptidoglycan binding GO:0042834 9.4 REG1A REG3A
7 hydrolase activity GO:0016787 9.32 CFTR CPA1 CPB1 CTRC LPL PLA2G2A
8 oligosaccharide binding GO:0070492 9.26 REG1A REG3A
Sources

Sources for Pancreatitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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