MCID: PNC044
MIFTS: 61

Pancreatitis

Categories: Bone diseases, Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Pancreatitis

MalaCards integrated aliases for Pancreatitis:

Name: Pancreatitis 12 24 29 55 6 43 44 15 40 17 72

Classifications:



External Ids:

Disease Ontology 12 DOID:4989
MeSH 44 D010195
NCIt 50 C3306
SNOMED-CT 68 75694006
ICD10 33 K85.9
UMLS 72 C0030305

Summaries for Pancreatitis

MedlinePlus : 43 The pancreas is a large gland behind the stomach and close to the first part of the small intestine. It secretes digestive juices into the small intestine through a tube called the pancreatic duct. The pancreas also releases the hormones insulin and glucagon into the bloodstream. Pancreatitis is inflammation of the pancreas. It happens when digestive enzymes start digesting the pancreas itself. Pancreatitis can be acute or chronic. Either form is serious and can lead to complications. Acute pancreatitis occurs suddenly and usually goes away in a few days with treatment. It is often caused by gallstones. Common symptoms are severe pain in the upper abdomen, nausea, and vomiting. Treatment is usually a few days in the hospital for intravenous (IV) fluids, antibiotics, and medicines to relieve pain. Chronic pancreatitis does not heal or improve. It gets worse over time and leads to permanent damage. The most common cause is heavy alcohol use. Other causes include cystic fibrosis and other inherited disorders, high levels of calcium or fats in the blood, some medicines, and autoimmune conditions. Symptoms include nausea, vomiting, weight loss, and oily stools. Treatment may also be a few days in the hospital for intravenous (IV) fluids, medicines to relieve pain, and nutritional support. After that, you may need to start taking enzymes and eat a special diet. It is also important to not smoke or drink alcohol. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Pancreatitis is related to pancreatic agenesis 1 and tropical calcific pancreatitis, and has symptoms including nausea and vomiting, constipation and abdominal pain. An important gene associated with Pancreatitis is TMEM67 (Transmembrane Protein 67), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and Pancreatic secretion. The drugs Somatostatin and Tramadol have been mentioned in the context of this disorder. Affiliated tissues include pancreas, testes and liver, and related phenotype is no effect.

Wikipedia : 75 Pancreatitis is a condition characterized by inflammation of the pancreas. The pancreas is a large organ... more...

GeneReviews: NBK190101

Related Diseases for Pancreatitis

Diseases in the Pancreatitis family:

Pancreatitis, Hereditary Autoimmune Pancreatitis
Acute Pancreatitis Autoimmune Pancreatitis Type 2
Autoimmune Pancreatitis Type 1 Recurrent Acute Pancreatitis

Diseases related to Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2437)
# Related Disease Score Top Affiliating Genes
1 pancreatic agenesis 1 34.6 SPINK1 SCT PNLIP CFTR
2 tropical calcific pancreatitis 34.5 SPINK1 REG1A PRSS2 PRSS1 CTRC
3 pancreatic cholera 34.3 SST SCT CCK
4 pancreatitis, hereditary 34.3 SPINK1 PRSS2 PRSS1 CTRC CPA1 CFTR
5 exocrine pancreatic insufficiency 34.2 SPINK1 SCT PNLIP CFTR CCK
6 pancreatic steatorrhea 34.2 SCT PRSS1 PNLIP CCK
7 vipoma 34.0 SST SCT
8 glucagonoma 33.9 SST SCT
9 pancreatic cancer 33.8 SST SPINK1 SCT PRSS1 CCK
10 recurrent acute pancreatitis 33.7 SPINK1 SCT PRSS1 LPL CTRC CFTR
11 alcoholic pancreatitis 33.5 SPINK1 SCT PRSS1 LPL CFTR CCK
12 cystic fibrosis 33.1 SPINK1 REG3A PRSS1 PNLIP CFTR
13 biliary dyskinesia 33.0 SCT CCK
14 familial lipoprotein lipase deficiency 32.9 PNLIP LPL APOC2
15 duodenal atresia 32.8 SCT CFTR
16 insulinomatosis and diabetes mellitus 32.7 SST SCT
17 multiple endocrine neoplasia, type i 32.6 SST SCT CASR
18 apolipoprotein c-ii deficiency 32.5 LPL APOC2
19 pancreas disease 32.1 SST SPINK1 SCT REG3A PRSS1 PNLIP
20 acute pancreatitis 31.7 VMP1 TMPRSS15 SST SPINK1 SCT REG3A
21 duodenal ulcer 31.5 SST SCT CCK
22 diarrhea 31.4 TMPRSS15 SST CFTR CCK
23 gastrointestinal system disease 31.0 SST SCT CCK
24 postcholecystectomy syndrome 30.7 SST CCK
25 steatorrhea 30.6 TMPRSS15 SST SCT PNLIP CFTR CCK
26 duodenogastric reflux 30.6 SST SCT CCK
27 linitis plastica 30.4 PRSS2 PRSS1
28 duodenal gastrinoma 30.3 SST SCT CCK
29 dumping syndrome 30.2 SST SCT
30 hyperlipoproteinemia, type v 29.6 LPL APOC2
31 pancreatic neuroendocrine tumor 12.8
32 pancreatic lipase deficiency 12.7
33 pancreatic ductal adenocarcinoma 12.7
34 autoimmune pancreatitis 12.6
35 pancreatic ductal carcinoma 12.6
36 melanoma-pancreatic cancer syndrome 12.6
37 pancreatic adenocarcinoma 12.5
38 neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 12.5
39 exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis 12.5
40 pancreatic agenesis 2 12.5
41 renal-hepatic-pancreatic dysplasia 12.5
42 pancreatic cancer 1 12.4
43 pancreatic cancer 4 12.4
44 pancreatic cancer 3 12.4
45 pancreatic agenesis 12.4
46 pancreatic cancer 2 12.4
47 pancreatic and cerebellar agenesis 12.4
48 pancreatic acinar cell adenocarcinoma 12.4
49 holoprosencephaly 12 with or without pancreatic agenesis 12.4
50 renal-hepatic-pancreatic dysplasia 1 12.4

Graphical network of the top 20 diseases related to Pancreatitis:



Diseases related to Pancreatitis

Symptoms & Phenotypes for Pancreatitis

UMLS symptoms related to Pancreatitis:


nausea and vomiting, constipation, abdominal pain, diarrhea, icterus, dyspepsia, heartburn, gastrointestinal gas

GenomeRNAi Phenotypes related to Pancreatitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 APOC2 CASR CCK CFTR CPA1 CPB1

Drugs & Therapeutics for Pancreatitis

Drugs for Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 523)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Somatostatin Approved, Investigational Phase 4 38916-34-6, 51110-01-1 53481605
2
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
3
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
4
Resveratrol Approved, Experimental, Investigational Phase 4 501-36-0 445154
5
Cefoperazone Approved, Investigational Phase 4 62893-19-0 44185
6
Nefopam Approved, Investigational Phase 4 13669-70-0
7
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
8 Pinaverium Approved Phase 4 59995-65-2
9
Meropenem Approved, Investigational Phase 4 119478-56-7, 96036-03-2 64778 441130
10
Cilastatin Approved, Investigational Phase 4 82009-34-5 5280454 6435415
11
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
12
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
13
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
14
Secretin Approved Phase 4 108153-74-8
15
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 441411 12560
16
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
17
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
18
Morphine Approved, Investigational Phase 4 57-27-2 5288826
19
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
20
Ceftazidime Approved Phase 4 78439-06-2, 72558-82-8 5481173
21
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
22
Metronidazole Approved Phase 4 443-48-1 4173
23
Liraglutide Approved Phase 4 204656-20-2 44147092
24
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
25
Thrombin Approved, Investigational Phase 4
26
Ritonavir Approved, Investigational Phase 4 155213-67-5 392622
27
Leflunomide Approved, Investigational Phase 4 75706-12-6 3899
28
Polyestradiol phosphate Approved Phase 4 28014-46-2
29
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
30
Etomidate Approved Phase 4 33125-97-2 36339 667484
31
Meperidine Approved Phase 4 57-42-1 4058
32
Anidulafungin Approved, Investigational Phase 4 166663-25-8 166548
33
Glycolic acid Approved, Investigational Phase 4 79-14-1 757
34
Darunavir Approved Phase 4 206361-99-1, 635728-49-3 213039
35
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
36
Lopinavir Approved Phase 4 192725-17-0 92727
37 Hydrotalcite Approved, Experimental, Investigational Phase 4 12304-65-3
38
Aluminum hydroxide Approved, Investigational Phase 4 21645-51-2
39
Sucralfate Approved Phase 4 54182-58-0
40
Magnesium hydroxide Approved, Investigational Phase 4 1309-42-8
41
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
42
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
43
Bezafibrate Approved, Investigational Phase 4 41859-67-0 39042
44
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
45
Glycerol Approved, Investigational Phase 4 56-81-5 753
46
Fosaprepitant Approved Phase 4 172673-20-0 219090
47
Aprepitant Approved, Investigational Phase 4 170729-80-3 151165 6918365
48
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
49
Protein C Approved Phase 4
50
Etanercept Approved, Investigational Phase 4 185243-69-0

Interventional clinical trials:

(show top 50) (show all 737)
# Name Status NCT ID Phase Drugs
1 Epinephrine Sprayed on the Papilla for the Prevention of Post-ERCP Pancreatitis Unknown status NCT02839356 Phase 4 epinephrine;normal saline
2 Comparative Study About the Impact of Two Oil Emulsions, One of Them Formulated With MCT, LCT, Olive Oil and Omega 3 Fatty Acids Versus Another One Formulated With MCT and LCT, Administered Intravenously on Severe Acute Pancreatitis Clinical Evolution Unknown status NCT01376817 Phase 4 Fat emulsion with MCT, LCT, olive oil and omega 3 fatty acids;Fat emulsion with MCT and LCT
3 Dexmedetomidine Hydrochloride in the Prevention of Organ Failure Following Unknown status NCT02691598 Phase 4 Infusion
4 Oral Resveratrol Before ERCP Redused Overall Pancreatitis in Patients Undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP): A Multi-center, Single-blinded, Randomized Controlled Trial Unknown status NCT02947932 Phase 4 Resveratrol;Indomethacin
5 Effect Observation Study of COX-2 Inhibitor to Prevent Post-ERCP Pancreatitis Unknown status NCT02964403 Phase 4 Cox-2;Indomethacin
6 Escalade or Deseacalade Antibiotic Use in Severe Acute Pancreatitis Unknown status NCT01992198 Phase 4 cefoperazone + metronidazole;Somatostatin;Meropenem
7 Pancreatitis CytoSorbents (CytoSorb®) Inflammatory Cytokine Removal: A Prospective Study. Unknown status NCT03082469 Phase 4
8 A MULTICENTER, RANDOMIZED, CONTROLLED STUDY OF EPIDURAL ANALGESIA FOR SEVERE ACUTE PANCREATITIS Unknown status NCT02126332 Phase 4
9 Prophylactic Pancreatic Duct Stent Placement After Endoscopic Snare Papillectomy of Duodenal Major Papillary Tumors; Prospective, Randomized, Controlled Study Unknown status NCT01737463 Phase 4
10 The Effect of Application of Fibrinogen/Thrombin-coated Collagen Patch (TachoSil®) in Pancreaticojejunostomy for Prevention of Pancreatic Fistula After Pancreatoduodenectomy Unknown status NCT03269955 Phase 4 Fibrinogen/thrombin-coated collagen patch
11 Application of Pinaverium Bromide in the Treatment of Patients With Post-cholecystectomy Sphincter of Oddi Dysfunction (SOD): A Randomized, Controlled and Multicenter Clinical Study Unknown status NCT02833103 Phase 4 Danshu Capsules;Pinaverium Bromide
12 DOLCE Study: Day-care Versus Overnight-stay Laparoscopic Cholecystectomy Randomized, Controlled Trial Unknown status NCT01052727 Phase 4
13 Dose Related Decrease in Triglycerides in Patients With Hypertriglyceridemia and Treated With Lovaza. Unknown status NCT00934219 Phase 4 Omega-3-Acid Ethyl Esters
14 An Open Pilot Study to Evaluate the Efficacy and Safety, Tolerability of Raltegravir(RAL)in Treatment-experienced HIV-1 Infected Adult Chinese Patients Unknown status NCT01201239 Phase 4 raltegravir
15 Evaluation of the Digestive and Metabolic Utilisation of Dietary Protein in Patients With Chronic Pancreatitis Completed NCT00957151 Phase 4 Creon
16 Randomized Controlled Trial on Sterile Fluid Collections Management in Acute Pancreatitis Completed NCT00786929 Phase 4 Conservative treatment
17 Evaluation of Pancreatic Tissue Penetration of Meronem® in the Prophylaxis of Septic Complications in Severe Pancreatitis Completed NCT00318994 Phase 4 Meropenem
18 Imipenem Prophylaxis of Infectious Complications in Patients With Acute Pancreatitis Completed NCT02897206 Phase 4 Imipenem;Placebo
19 Timing of Indomethacin Administration for the Prevention of Post-ERCP Pancreatitis (PEP) Completed NCT02111707 Phase 4 Rectal indomethacin 100mg one time before or after ERCP
20 A Prospective Study of Celiac Block Technique: One Injection or Two? Completed NCT00583479 Phase 4
21 Double-blind Randomized Study to Determine the Efficacy of Intramuscular Vitamin D3 Supplementation in Tropical Calcific Pancreatitis Completed NCT00956839 Phase 4 Vitamin D3 (Cholecalciferol)
22 Assess the Effect of Erythromycin on the Rate of Success in Placement of a Self-propelled Feeding Tube Completed NCT00999232 Phase 4 Erythromycin;Placebo
23 A Multicentre, Randomised, Double-blind, Placebo-controlled, Study on the Use of Prophylactic Meropenem Therapy in Subjects With Severe Acute Necrotizing Pancreatitis Completed NCT00061438 Phase 4 meropenem
24 A Prospective Randomised Trial of 0.025 Wire Guided Cannulation Versus Current Practice 0.035 Wire Guided Cannulation Completed NCT01408264 Phase 4
25 The Impact of Early Enteral Nutrition on the Clinical Outcomes of Severe Acute Pancreatitis Patients: A Randomized Control Trial Completed NCT00995098 Phase 4
26 Diclophenac Potassium Versus Ceftazidime for Reduction of Post ERCP Pancreatitis in Average Risk Patients-double Blind, Randomised Controlled Trial Completed NCT01784445 Phase 4 Ceftazidime
27 Enteral Nutrition for Treatment of Acute Pancreatitis - a Prospective, Randomized Clinical Trial Completed NCT01965873 Phase 4
28 APCAP - Activated Protein C in Severe Acute Pancreatitis: A Double-blind Randomized Human Pilot Trial Completed NCT01017107 Phase 4 Activated protein C
29 Dexmedetomidine vs Placebo in ERCP Sedation.A Randomized Pilot Study Completed NCT01070680 Phase 4 Precedex;sodium chlorid 0,9%
30 A Double-Blind, Randomized, Placebo Controlled Intervention Study to Assess the Impact of Sitagliptin 100 mg/Day for 1 Year on Insulin Independence Following Pancreatectomy and Autoislet Transplantation Completed NCT01186562 Phase 4 Sitagliptin;Placebo
31 Nutritional and Metabolic Evaluation of a Tube Feeding Immune Enhancing Diet in ICU Patients Completed NCT00560157 Phase 4
32 The Correlations Between Early Enteral Nutrition and Intra-abdominal Pressure in Severe Acute Pancreatitis Completed NCT01507766 Phase 4 early enteral nutrition;Delayed enteral nutrition
33 Enzyme Substitution in Exocrine Pancreatic Insufficiency; Self Administration Against a Fixed Dose Regimen Completed NCT01430234 Phase 4 Panzytrat 25.000 FIP-E units of Lipase
34 Covered Versus Uncovered Metal Stents for Management of Distal Malignant Biliary Obstruction? Results of a Randomized Prospective Study. Completed NCT00280709 Phase 4
35 DGT Versus TPS in Patients With Initial PD Cannulation by Chance; Prospective Randomized Multi-center Study Completed NCT01744847 Phase 4
36 Studie Naar De Effectiviteit Van Ursodeoxycholzuur Ter Preventie Van Galsteen-Gerelateerde Klachten Bij patiënten in Afwachting Van Een Cholecystectomie Completed NCT00161083 Phase 4 ursodeoxycholic acid
37 Beijing Chao-Yang Hospital, Capital Medical University Completed NCT03297879 Phase 4 Exenatide or metformin hydrochloride
38 Pilot Study for the Evaluation of the Safety and the Feasibility of Treatment Simplification to Atazanavir/Ritonavir + Lamivudine in Patients Stably Treated With Two NRTIs + Atazanavir/Ritonavir With Optimal Virologic Response. Completed NCT00885482 Phase 4 Lamiduvine (Epivir);Atazanavir (Reyataz);Ritonavir (Norvir)
39 A Study of Safety and Efficacy of Leflunomide for Maintenance of Remission in IgG4 Related Disease Completed NCT02703194 Phase 4 Prednisone;Leflunomide
40 Etomidate With Meperidine vs Midazolam With Meperidine for Sedation During Endodscopic Retrograde Cholangiopancreatogram (ERCP) Completed NCT02027311 Phase 4 Etomidate;Midazolam;Meperidine
41 A Pilot Study for the Use of Biomarkers and Early Treatment of Invasive Candidiasis in ICU Patients Completed NCT01734525 Phase 4 Anidulafungin
42 Use of Polyethylene Glycolic Acid or Tachocomb to Prevent Pancreatic Fistula Following Distal Pancreatectomy: Prospective Multicenter Randomized Study Completed NCT01550406 Phase 4
43 A Randomised, Double Blind Cross-over Study of Serial MRCP Following Morphine-neostigmine and Secretin Provocation in Healthy Volunteers Completed NCT01134848 Phase 4 Morphine;Neostigmine;0.9% saline;Secretin;0.9% saline
44 Evaluation of Safety and Efficacy of Raltegravir/Darunavir Combination in Antiretroviral-Naive Patients Completed NCT00677300 Phase 4 Raltegravir;Darunavir;Ritonavir;Tenofovir/Emtricitabine
45 A Phase IV, Randomized, Double-blind, Placebo-controlled, Parallel-group Trial to Assess the Effect of 12-week Treatment With the Glucagon-like Peptide-1 Receptor Agonist (GLP-1RA) Liraglutide or Dipeptidyl Peptidase-4 Inhibitor (DPP-4i) Sitagliptin on the Cardiovascular, Renal and Gastrointestinal System in Insulin-naïve Patients With Type 2 Diabetes (T2DM). Completed NCT01744236 Phase 4 Liraglutide;Sitagliptin;Exenatide;Liraglutide placebo;Sitagliptin placebo;Exenatide placebo;L-NMMA
46 Exploratory, Cross-sectional Study to Compare the Virologic Efficacy in Cerebrospinal Fluid (CSF) and Neurocognitive State in Patients Infected by HIV-1 Long-term Treatment (> 3 Years) With Lopinavir / Ritonavir Monotherapy Completed NCT01116817 Phase 4
47 A Comparison of Effectiveness of Oral Sucrolfate, Alginate and Hydrotalcide in Dispeptic Pain Treatment: Randomized Trial Completed NCT03635372 Phase 4 Alginate;Sucralfate;Hydrotalcite
48 Effect of Early Nutritional Therapy on Frailty, Functional Outcomes and Recovery of Undernourished Medical Inpatients Trial: The EFFORT Trial Completed NCT02517476 Phase 4
49 To Study the Effects of Lipid Emulsion on Hemodynamics in Organophosphate Compound Poisoning Completed NCT03564574 Phase 4
50 Randomised and Prospective Clinical Study to Evaluate the Efficacy and Safety of Lopinavir/Ritonavir Monotherapy Versus Darunavir/Ritonavir Monotherapies as Simplification Switching Strategies of PI/NNRTI-Triple Therapy Based-Regimens Completed NCT00994344 Phase 4 Darunavir/ritonavir;Lopinavir/ritonavir

Search NIH Clinical Center for Pancreatitis

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Hyoscyamine
Propantheline
Propantheline Bromide

Cochrane evidence based reviews: pancreatitis

Genetic Tests for Pancreatitis

Genetic tests related to Pancreatitis:

# Genetic test Affiliating Genes
1 Pancreatitis 29

Anatomical Context for Pancreatitis

MalaCards organs/tissues related to Pancreatitis:

41
Pancreas, Testes, Liver, Lung, Colon, Kidney, Bone

Publications for Pancreatitis

Articles related to Pancreatitis:

(show top 50) (show all 30199)
# Title Authors PMID Year
1
The natural history of hereditary pancreatitis: a national series. 9 38 4
18755888 2009
2
Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis. 9 38 4
18172691 2008
3
Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis. 9 38 4
18059268 2008
4
Diabetes mellitus in Tropical Chronic Pancreatitis Is Not Just a Secondary Type of Diabetes. 9 38 4
15258409 2004
5
SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis. 9 38 4
10982753 2000
6
Outcomes from different minimally invasive approaches for infected necrotizing pancreatitis. 38 17
31192974 2019
7
Total pancreatectomy and islet autotransplantation in chronic pancreatitis: recommendations from PancreasFest. 38 4
24555976 2014
8
Pancreatitis-diabetes-pancreatic cancer: summary of an NIDDK-NCI workshop. 38 4
24152948 2013
9
Variants in CPA1 are strongly associated with early onset chronic pancreatitis. 38 4
23955596 2013
10
Detection, evaluation and treatment of diabetes mellitus in chronic pancreatitis: recommendations from PancreasFest 2012. 38 4
23890130 2013
11
CFTR, SPINK1, CTRC and PRSS1 variants in chronic pancreatitis: is the role of mutated CFTR overestimated? 38 4
22427236 2013
12
Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus. 38 4
23100216 2013
13
Endoscopic therapy is effective for patients with chronic pancreatitis. 38 4
22245964 2012
14
Whole exome sequencing identifies multiple, complex etiologies in an idiopathic hereditary pancreatitis kindred. 38 4
22572128 2012
15
Genetics of pancreatitis: an update for clinicians and genetic counselors. 38 4
22314809 2012
16
Drug-induced pancreatitis. 38 4
22314811 2012
17
Oxidative stress in chronic pancreatitis: pathophysiological relevance and management. 38 4
21902596 2011
18
Genetics of pancreatitis. 38 4
21844754 2011
19
Quality of life improves for pediatric patients after total pancreatectomy and islet autotransplant for chronic pancreatitis. 38 4
21683160 2011
20
Imaging of acute pancreatitis. 38 4
21785045 2011
21
High incidence of PRSS1 and SPINK1 mutations in Korean children with acute recurrent and chronic pancreatitis. 38 4
21415673 2011
22
Correlation of histopathology, islet yield, and islet graft function after islet autotransplantation in chronic pancreatitis. 38 4
21404456 2011
23
Use and perceived effectiveness of non-analgesic medical therapies for chronic pancreatitis in the United States. 38 4
21083584 2011
24
Therapeutic implications of oxidative stress in acute and chronic pancreatitis. 38 4
20543682 2010
25
The role of alcohol and smoking in pancreatitis. 38 4
20125091 2010
26
Outcomes of interventional ERCP in hereditary pancreatitis. 38 4
19713862 2010
27
Alcohol consumption, cigarette smoking, and the risk of recurrent acute and chronic pancreatitis. 38 4
19506173 2009
28
A randomized controlled trial of antioxidant supplementation for pain relief in patients with chronic pancreatitis. 38 4
18952082 2009
29
Assessment of chronic pancreatitis: utility of diffusion-weighted MR imaging with secretin enhancement. 38 4
19001148 2009
30
Hereditary pancreatitis caused by a double gain-of-function trypsinogen mutation. 38 4
18461367 2008
31
Risk of pancreatic adenocarcinoma in patients with hereditary pancreatitis: a national exhaustive series. 38 4
18184119 2008
32
Copy number variations in chronic pancreatitis. 38 4
19287144 2008
33
Trypsinogen copy number mutations in patients with idiopathic chronic pancreatitis. 38 4
18063422 2008
34
Hereditary pancreatitis amlodipine trial: a pilot study of a calcium-channel blocker in hereditary pancreatitis. 38 4
18090235 2007
35
Genetic counseling for nonsyndromic pancreatitis. 38 4
17533082 2007
36
Pain in chronic pancreatitis and pancreatic cancer. 38 4
17533083 2007
37
13C-mixed triglyceride breath test to assess oral enzyme substitution therapy in patients with chronic pancreatitis. 38 4
17445754 2007
38
Yoga: a tool for improving the quality of life in chronic pancreatitis. 38 4
17230607 2007
39
Practice guidelines in acute pancreatitis. 38 4
17032204 2006
40
Cigarette smoking accelerates progression of alcoholic chronic pancreatitis. 38 4
15753536 2005
41
Genetic counseling for hereditary pancreatitis--the role of molecular genetics testing for the cationic trypsinogen gene, cystic fibrosis and serine protease inhibitor Kazal type 1. 9 4
15528021 2004
42
Cigarette smoking as a risk factor for pancreatic cancer in patients with hereditary pancreatitis. 38 4
11448279 2001
43
Chronic pancreatitis: diagnosis, classification, and new genetic developments. 38 4
11179244 2001
44
Pancreatitis induced by environmental toxins. 38 4
11138962 2001
45
Antioxidant treatment in hereditary pancreatitis. A pilot study on three young patients. 38 4
11303976 2001
46
Genetic testing for hereditary pancreatitis: guidelines for indications, counselling, consent and privacy issues. 38 4
12120217 2001
47
Pancreatic cancer in hereditary pancreatitis: consensus guidelines for prevention, screening and treatment. 38 4
12120218 2001
48
Early prediction of severity in acute pancreatitis by urinary trypsinogen activation peptide: a multicentre study. 38 4
10859041 2000
49
Hereditary pancreatitis: new insights, new directions. 38 4
11030605 1999
50
Fecal pancreatic elastase 1 is inaccurate in the diagnosis of chronic pancreatitis. 38 4
8884841 1996

Variations for Pancreatitis

ClinVar genetic disease variations for Pancreatitis:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 TMEM67 NM_153704.5(TMEM67): c.1321C> T (p.Arg441Cys) single nucleotide variant Pathogenic/Likely pathogenic rs752362727 8:94798483-94798483 8:93786255-93786255
2 TMEM67 NM_153704.5(TMEM67): c.1843T> C (p.Cys615Arg) single nucleotide variant Pathogenic/Likely pathogenic rs201893408 8:94808198-94808198 8:93795970-93795970
3 CFTR NM_000492.3(CFTR): c.1523T> G (p.Phe508Cys) single nucleotide variant Conflicting interpretations of pathogenicity rs74571530 7:117199648-117199648 7:117559594-117559594
4 CFTR NM_000492.3(CFTR): c.2991G> C (p.Leu997Phe) single nucleotide variant Conflicting interpretations of pathogenicity rs1800111 7:117250575-117250575 7:117610521-117610521

Copy number variations for Pancreatitis from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 194974 5 147184338 147191453 Deletion SPINK1 Pancreatitis
2 220321 7 137300000 142800000 Triplication PRSS1 Pancreatitis
3 220322 7 137300000 142800000 Triplication PRSS2 Pancreatitis
4 221070 7 142136892 142140501 Triplication PRSS1 Pancreatitis
5 221298 7 142800000 147500000 Triplication PRSS1 Pancreatitis

Expression for Pancreatitis

Search GEO for disease gene expression data for Pancreatitis.

GO Terms for Pancreatitis

Cellular components related to Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.83 SST SPINK1 SCT REG3A REG1A PRSS2
2 extracellular space GO:0005615 9.47 SST SPINK1 SCT REG3A REG1A PRSS2
3 very-low-density lipoprotein particle GO:0034361 9.26 LPL APOC2
4 chylomicron GO:0042627 9.16 LPL APOC2

Biological processes related to Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.8 TMPRSS15 PRSS2 PRSS1 CTRC CPB1 CPA1
2 sperm capacitation GO:0048240 9.48 SPINK1 CFTR
3 cobalamin metabolic process GO:0009235 9.46 PRSS1 CTRC
4 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.43 PLA2G2A LPL
5 antimicrobial humoral response GO:0019730 9.43 REG3A PRSS2 PLA2G2A
6 very-low-density lipoprotein particle remodeling GO:0034372 9.4 LPL APOC2
7 chylomicron remodeling GO:0034371 9.37 LPL APOC2
8 lipid catabolic process GO:0016042 9.26 PNLIP PLA2G2A LPL APOC2
9 cell wall disruption in other organism GO:0044278 9.16 REG3A REG1A
10 digestion GO:0007586 8.92 SST PRSS2 PRSS1 CCK

Molecular functions related to Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.62 TMPRSS15 PRSS2 PRSS1 CTRC
2 hormone activity GO:0005179 9.54 SST SCT CCK
3 serine-type peptidase activity GO:0008236 9.46 TMPRSS15 PRSS2 PRSS1 CTRC
4 triglyceride lipase activity GO:0004806 9.43 PNLIP LPL
5 peptidase activity GO:0008233 9.43 TMPRSS15 PRSS2 PRSS1 CTRC CPB1 CPA1
6 peptidoglycan binding GO:0042834 9.4 REG3A REG1A
7 hydrolase activity GO:0016787 9.28 TMPRSS15 PRSS2 PRSS1 PNLIP PLA2G2A LPL
8 oligosaccharide binding GO:0070492 9.26 REG3A REG1A

Sources for Pancreatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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