Pancytopenia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PNC001 MIFTS: 51	Pancytopenia Categories: Blood diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Pancytopenia

MalaCards integrated aliases for Pancytopenia:

Name: Pancytopenia ¹² ²⁹ ⁵⁵ ⁴⁴ ¹⁵ ⁷³

Classifications:

MalaCards categories:
Anatomical: Blood diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:12450

ICD10 ³³ D61.81

ICD9CM ³⁵ 284.1

MeSH ⁴⁴ D010198

NCIt ⁵⁰ C34889 C80693

UMLS ⁷³ C0030312

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Summaries for Pancytopenia

Disease Ontology : ¹² An anemia that is characterized by a reduction in the number of red blood cells, white blood cells, and platelets.

MalaCards based summary : Pancytopenia is related to fanconi anemia, complementation group a and dyskeratosis congenita. An important gene associated with Pancytopenia is SAMD9L (Sterile Alpha Motif Domain Containing 9 Like), and among its related pathways/superpathways are PI3K-Akt signaling pathway and JAK-STAT signaling pathway (KEGG). The drugs Benzocaine and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and liver, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : ⁷⁶ Pancytopenia is a medical condition in which there is a reduction in the number of red and white blood... more...

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Related Diseases for Pancytopenia

Diseases related to Pancytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 379)

#	Related Disease	Score	Top Affiliating Genes
1	fanconi anemia, complementation group a	32.5	DHFR DKC1 IL3 LIG4 THPO
2	dyskeratosis congenita	32.2	CSF2 CSF3 DKC1 LIG4 TERT
3	amegakaryocytic thrombocytopenia, congenital	31.9	IL3 MPL THPO
4	diamond-blackfan anemia	30.7	CSF2 EPO IL3 MPL THPO
5	aplastic anemia	30.3	CD55 CSF1 CSF2 CSF3 DKC1 EPO
6	hypersplenism	30.0	CSF2 EPO THPO
7	thrombocytopenia	29.9	CSF3 MPL THPO
8	neutropenia	29.6	CSF2 CSF3 IL3 TPMT
9	myeloma, multiple	29.6	CSF2 CSF3 EPO LIG4
10	myelofibrosis	29.6	CSF3 EPO IL3 MPL THPO
11	malaria	29.4	CD55 CSF2 CSF3 DHFR EPO TCN2
12	granulocytopenia	29.2	CSF2 CSF3 IL3
13	cyclic neutropenia	29.2	CSF2 CSF3 IL3
14	deficiency anemia	29.2	CSF3 EPO IL3 THPO
15	refractory anemia	29.2	EPO IL3 MPL
16	severe congenital neutropenia	29.2	CSF2 CSF3 IL3
17	leukemia, acute myeloid	28.9	CSF2 CSF3 IL3 MPL SAMD9L TERT
18	polycythemia	28.9	EPO IL3 MPL THPO
19	polycythemia vera	28.9	EPO IL3 MPL THPO
20	myelodysplastic syndrome	28.7	CD55 CSF1 CSF2 CSF3 EPO IL3
21	thrombocytosis	28.7	CSF2 EPO IL3 MPL THPO
22	leukemia, chronic myeloid	28.5	CSF2 CSF3 EPO IL3 MPL THPO
23	ataxia-pancytopenia syndrome	12.5
24	samd9l-related ataxia-pancytopenia syndrome	12.2
25	pancytopenia and occlusive vascular disease	12.0
26	dyskeratosis congenita, x-linked	11.5
27	sackey sakati aur syndrome	11.5
28	fanconi anemia, complementation group c	11.3
29	fanconi anemia, complementation group d2	11.3
30	fanconi anemia, complementation group b	11.3
31	hemophagocytic lymphohistiocytosis	11.2
32	fanconi-like syndrome	11.2
33	radioulnar synostosis with amegakaryocytic thrombocytopenia 2	11.0
34	bone marrow failure syndrome 3	11.0
35	cerebroretinal microangiopathy with calcifications and cysts 2	11.0
36	bone marrow failure syndrome 2	11.0
37	immunodeficiency, common variable, 13	11.0
38	evans' syndrome	11.0
39	osteopetrosis, autosomal dominant 2	10.9
40	gaucher disease, type iii	10.9
41	methylmalonyl-coa epimerase deficiency	10.9
42	osteopetrosis, autosomal recessive 1	10.9
43	osteopetrosis, autosomal recessive 2	10.9
44	osteopetrosis, autosomal recessive 5	10.9
45	osteopetrosis, autosomal recessive 3	10.9
46	transcobalamin ii deficiency	10.9
47	lymphoproliferative syndrome, x-linked, 2	10.9
48	lymphoproliferative syndrome, x-linked, 1	10.9
49	hemophagocytic lymphohistiocytosis, familial, 2	10.9
50	radioulnar synostosis with amegakaryocytic thrombocytopenia 1	10.9

Graphical network of the top 20 diseases related to Pancytopenia:

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Symptoms & Phenotypes for Pancytopenia

MGI Mouse Phenotypes related to Pancytopenia:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10.21	CD55 CSF1 CSF2 CSF3 DHFR DKC1
2	homeostasis/metabolism	MP:0005376	10.13	CSF1 CSF2 DHFR DKC1 EPO LIG4
3	immune system	MP:0005387	10.07	CD55 CSF1 CSF2 CSF3 DHFR DKC1
4	integument	MP:0010771	9.7	CSF1 CSF2 CSF3 DHFR DKC1 EPO
5	mortality/aging	MP:0010768	9.7	CSF1 CSF2 DHFR DKC1 EPO LIG4
6	neoplasm	MP:0002006	9.1	CSF2 DKC1 LIG4 MGMT SAMD9L TERT

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Drugs & Therapeutics for Pancytopenia

Drugs for Pancytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 226)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Benzocaine

Approved, Investigational

Phase 4,Phase 2,Not Applicable

94-09-7, 1994-09-7

2337

tannic acid

Approved

Phase 4,Phase 2,Not Applicable

Lenograstim

Approved, Investigational

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

135968-09-1

Prednisone

Approved, Vet_approved

Phase 4,Phase 2,Phase 1

53-03-2

5865

Busulfan

Approved, Investigational

Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable

55-98-1

2478

Fludarabine

Approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

75607-67-9, 21679-14-1

30751

Oprelvekin

Approved, Investigational

Phase 4

145941-26-0

Peginterferon alfa-2a

Approved, Investigational

Phase 4

198153-51-4

5360545

Ribavirin

Approved

Phase 4

36791-04-5

37542

Pantoprazole

Approved

Phase 4

102625-70-7

4679

Cilostazol

Approved, Investigational

Phase 4

73963-72-1

2754

Clopidogrel

Approved

Phase 4

113665-84-2, 120202-66-6

60606

Ticlopidine

Approved

Phase 4

55142-85-3

5472

Dopamine

Approved

Phase 4

51-61-6, 62-31-7

681

Haloperidol

Approved

Phase 4

52-86-8

3559

Treosulfan

Investigational

Phase 4,Phase 2

299-75-2

9296

Immunosuppressive Agents

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

Cyclosporins

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antiviral Agents

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

Immunologic Factors

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

Antimetabolites

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

Anti-Infective Agents

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

Antilymphocyte Serum

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Protective Agents

Phase 4,Phase 2,Phase 1

Antineoplastic Agents, Alkylating

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

Alkylating Agents

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

decanoic acid

Phase 4,Phase 1,Phase 2

Interferon-alpha

Phase 4

interferons

Phase 4

Anti-Ulcer Agents

Phase 4

Antacids

Phase 4

Gastrointestinal Agents

Phase 4,Phase 2,Phase 1,Not Applicable

Proton Pump Inhibitors

Phase 4

Peripheral Nervous System Agents

Phase 4,Phase 2,Phase 1,Not Applicable

Neuroprotective Agents

Phase 4,Phase 2,Phase 1

Autonomic Agents

Phase 4,Phase 2,Phase 1

Antiemetics

Phase 4,Phase 2,Phase 1

Fibrinolytic Agents

Phase 4

Cytochrome P-450 CYP2C19 Inhibitors

Phase 4

Phosphodiesterase Inhibitors

Phase 4

Vasodilator Agents

Phase 4

Anti-Asthmatic Agents

Phase 4

Phosphodiesterase 3 Inhibitors

Phase 4

Platelet Aggregation Inhibitors

Phase 4

Respiratory System Agents

Phase 4

Bronchodilator Agents

Phase 4

Purinergic P2Y Receptor Antagonists

Phase 4

Neurotransmitter Agents

Phase 4

Purinergic P2 Receptor Antagonists

Phase 4

Cytochrome P-450 Enzyme Inhibitors

Phase 4,Phase 1

Interventional clinical trials:

(show top 50) (show all 183)

#	Name	Status	NCT ID	Phase	Drugs
1	Different Doses of Anti-thymocyte Globin to Treat Child Severe Aplastic Anemia	Unknown status	NCT01997372	Phase 4	ATG
2	Effect of rhIL-11 in Patients With Thrombocytopenia for Childhood ALL	Completed	NCT02314273	Phase 4	rhIL-11
3	A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) Plus COPEGUS (Ribavirin) in Patients With Chronic Hepatitis C (CHC) Genotype 1 and Human Immunodeficiency Virus-1 (HIV-1) Co-infection	Completed	NCT00353418	Phase 4	Peginterferon alfa-2a;Ribavirin;Ribavirin
4	Stress Ulcer Prophylaxis in the Intensive Care Unit	Completed	NCT02467621	Phase 4	Pantoprazole
5	Eltrombopag in Children With Idiopathic Aplastic Anemia	Recruiting	NCT03243656	Phase 4	Eltrombopag
6	Diabetic Artery Obstruction: is it Possible to Reduce Ischemic Events With Cilostazol?	Recruiting	NCT02983214	Phase 4	Clopidogrel;Cilostazol
7	ALL SCTped FORUM - Pharmacogenomic Study (add-on Study)	Recruiting	NCT02670564	Phase 4
8	Agents Intervening Against Delirium in Intensive Care Unit	Recruiting	NCT03392376	Phase 4	Haloperidol Injection
9	The Impact of Red Cell Age on Product Utilization in the Chronically Transfused Outpatient Population	Unknown status	NCT02393508	Phase 3
10	Risk-Adapted Allogeneic Stem Cell Transplantation For Mixed Donor Chimerism In Patients With Non-Malignant Diseases	Unknown status	NCT01019876	Phase 2, Phase 3	Fludarabine;Cyclophosphamide;Cyclophosphamide 40;Cyclophosphamide 30
11	Erythropoietin (EPO) and Granulocyte-Colony Stimulating Factor (G-CSF) for Low-Risk Myelodysplastic Syndromes (MDS)	Unknown status	NCT00234143	Phase 2, Phase 3	Darbepoetin
12	Comparison of Cy-Atg vs Flu-Atg for the Conditioning Therapy in Allo-HCT for Adult Aplastic Anemia	Unknown status	NCT01145976	Phase 3	Cy-ATG;Flu-ATG
13	Stem Cell Transplant for Bone Marrow Failure Syndromes	Completed	NCT00176878	Phase 2, Phase 3	Fludarabine monophosphate;Busulfan
14	Comparison of Cy-Atg Vs Cy-Flu-Atg for the Conditioning Therapy in Allo-HCT	Completed	NCT00774527	Phase 3	Cyclophosphamide-fludarabine-anti thymocyte globulin
15	Cyclosporine Eye Drops in Preventing Graft-Versus-Host Disease of the Eye in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer or Bone Marrow Failure Disorder	Completed	NCT00755040	Phase 3	cyclosporine ophthalmic emulsion
16	Multi-Center Trial of Anti-Thymocyte Globulin in Treatment of Aplastic Anemia and Other Hematologic Disorders	Completed	NCT00000597	Phase 3	antilymphocyte serum;nandrolone
17	Eculizumab to Treat Paroxysmal Nocturnal Hemoglobinuria	Completed	NCT00098280	Phase 3	Eculizumab
18	Maribavir Versus Oral Ganciclovir For The Prevention of Cytomegalovirus (CMV) Disease in Liver Transplant Recipients	Completed	NCT00497796	Phase 3	maribavir;ganciclovir
19	A Study of MK-3415, MK-6072, and MK-3415A in Participants Receiving Antibiotic Therapy for Clostridium Difficile Infection (MK-3415A-001)	Completed	NCT01241552	Phase 3	SOC
20	A Study of MK-6072 and MK-3415A in Participants Receiving Antibiotic Therapy for Clostridium Difficile Infection (MK-3415A-002)	Completed	NCT01513239	Phase 3	SOC
21	Peripheral Blood Allogenic Stem Cell Transplantation Using Non-anti Thymocyte Globulin Regimens in Severe Aplastic Anemia Patients	Not yet recruiting	NCT03295058	Phase 2, Phase 3	Non ATG Conditioning regimen;GVHD Prophylaxis;ATG conditioning regimen
22	A Study Evaluating Epoetin Alfa 40,000 IU (International Units) Every Week or 80,000 IU Every Week Compared to Placebo in Patients With Low or Intermediate-1 Risk Myelodysplastic Syndromes at Risk for Transfusion	Terminated	NCT00695396	Phase 3	Placebo;Epoetin alfa;Placebo;Epoetin alfa
23	Safety and Efficacy of Levamisole Combined With Cyclosporine A in Patients With Subclinical Paroxysmal Nocturnal Hemoglobinuria and PNH in the Setting of Another Bone Marrow Failure Syndromes(PNH-2013)	Unknown status	NCT01760096	Phase 2	Levamisole+cyclosporin A+Glucocorticoids;cyclosporin A+Glucocorticoids;Glucocorticoids
24	Limiting Chemotherapy Side Effects by Using Moxa	Unknown status	NCT02781155	Phase 1, Phase 2
25	Nandrolone Decanoate in the Treatment of Telomeropathies	Unknown status	NCT02055456	Phase 1, Phase 2	Nandrolone Decanoate
26	Eltrombopag for Enhancing Platelet Engraftment in Adult Patients Undergoing Cord Blood Transplantation	Unknown status	NCT01757145	Phase 2	Eltrombopag
27	A Single-Arm Phase 2 Study With Optimized Standard Protocol for Severe Aplastic Anemia	Unknown status	NCT02203396	Phase 2	rabbit ATG, Cyclosporine, Levamisole
28	Clinical Phase II Trial to Evaluate CD34+ Cells Mobilization and Collection in Patients With Fanconi Anemia for Subsequent Transduction With a Lentiviral Vector Carring FANCA Gene. FANCOSTEM-1	Unknown status	NCT02931071	Phase 2	filgrastim;plerixafor
29	Prospective Study of Mylotarg and G-CSF in Acute Myeloid Leukemia Treatment	Unknown status	NCT01698879	Phase 2	Mylotarg
30	Safety and Efficacy of Levamisole Combined With Cyclosporine A in Patients With Classic Paroxysmal Nocturnal Hemoglobinuria	Unknown status	NCT01642979	Phase 2	Levamisole+cyclosporin A+Glucocorticoids;cyclosporin A+Glucocorticoids;Glucocorticoids
31	Rabbit Antithymocyte Globulin Versus Campath-1H for Treating Severe Aplastic Anemia	Completed	NCT00065260	Phase 2	Campath-1H;r-ATG;CsA
32	Donor Stem Cell Transplant After Busulfan, Fludarabine, Methylprednisolone, and Antithymocyte Globulin in Treating Patients With Bone Marrow Failure Syndrome	Completed	NCT00731328	Phase 2
33	Allogeneic Mixed Chimerism Stem Cell Transplant Using Campath for Hemoglobinopathies & Bone Marrow Failure Syndromes	Completed	NCT00004143	Phase 2	Campath, Chemo and/or TBI Allo SCT
34	Three Immunosuppressive Treatment Regimens for Severe Aplastic Anemia	Completed	NCT00260689	Phase 2	Cyclosporine;Alemtuzumab
35	Cyclophosphamide Plus Cyclosporine in Treatment-Naive Severe Aplastic Anemia	Completed	NCT01193283	Phase 1, Phase 2	Cyclophosphamide;Cyclosporine
36	Phase II Pilot Study of Granulocyte Colony-Stimulating Factor for Inherited Bone Marrow Failure Syndromes	Completed	NCT00004787	Phase 2	filgrastim
37	A Pilot Study of Fludarabine Plus Cyclophosphamide in Refractory Severe Aplastic Anemia	Completed	NCT01187017	Phase 1, Phase 2	Cyclophosphamide;Fludarabine
38	Reduced Intensity Conditioning Using CD3+/CD19+ Depletion for Non Malignant Transplantable Diseases	Completed	NCT02277639	Phase 2
39	Improving Immunosuppressive Treatment for Patients With Severe Aplastic Anemia	Completed	NCT00061360	Phase 2	cyclosporine;Rapamune;ATG
40	Chemotherapy, Radiation Therapy, and Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer	Completed	NCT00003270	Phase 2	busulfan;cyclophosphamide;cyclosporine;methylprednisolone
41	Bone Marrow Transplant Plus Cyclophosphamide and Total-Body Irradiation in Treating Patients With Hematologic Cancer	Completed	NCT00002809	Phase 2	cyclophosphamide;methotrexate;tacrolimus
42	Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer or Other Hematologic or Metabolic Diseases	Completed	NCT00003662	Phase 2	busulfan;cyclophosphamide;cyclosporine;melphalan;methylprednisolone
43	Bortezomib to Treat Significant Complication of HSCT	Completed	NCT01929980	Phase 2	Bortezomib
44	Danazol for Genetic Bone Marrow and Lung Disorders	Completed	NCT01441037	Phase 1, Phase 2	Danazol
45	Mobilization and Collection of Peripheral Blood Stem Cells in Patients With Fanconi Anemia Using G-CSF and AMD3100	Completed	NCT00479115	Phase 1, Phase 2	AMD3100
46	Rituximab to Treat Moderate Aplastic Anemia, Pure Red Cell Aplasia, or Diamond Blackfan Anemia	Completed	NCT00229619	Phase 2	Rituximab
47	Doxercalciferol in Treating Patients With Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia	Completed	NCT00052832	Phase 2
48	High-Dose Immunosuppression and Autologous Transplantation for Multiple Sclerosis (HALT MS) Study	Completed	NCT00288626	Phase 2	Granulocyte-colony stimulating factor (G-CSF) and prednisone;Carmustine, etoposide, cytarabine, and melphalan (BEAM)
49	Antithymocyte Globulin and Cyclosporine to Treat Myelodysplasia	Completed	NCT00005937	Phase 2	Antithymocyte globulin;Cyclosporine
50	Study of the Efficacy and Safety of Lenalidomide in Combination With Cyclosporine A in Patients With Myelodysplastic Syndromes	Completed	NCT00840827	Phase 2	lenalidomide;cyclosporine A

Search NIH Clinical Center for Pancytopenia

Cochrane evidence based reviews: pancytopenia

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Genetic Tests for Pancytopenia

Genetic tests related to Pancytopenia:

#	Genetic test	Affiliating Genes
1	Pancytopenia ²⁹

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Anatomical Context for Pancytopenia

MalaCards organs/tissues related to Pancytopenia:

⁴¹

Bone, Bone Marrow, Liver, T Cells, Kidney, Myeloid, B Cells

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Publications for Pancytopenia

Articles related to Pancytopenia:

(show top 50) (show all 1057)

#	Title	Authors	Year
1	Fever with pancytopenia: unusual presentation of extrapulmonary tuberculosis: a case report. ( 29506574 )	Dalugama C....Gawarammana I.B.	2018
2	Visceral leishmaniasis presenting with pancytopenia and circulating blastlike lymphocytes. ( 29930152 )	Assaf N.P....Chakhachiro Z.I.	2018
3	Ecthyma Gangrenosum: Vulvar Ulcers, Pseudomonas and Pancytopenia, A Case Report of an 18- Month-Old Female. ( 29885367 )	Todd N....Fleming N.	2018
4	Approach to pancytopenia: Diagnostic algorithm for clinical hematologists. ( 29555368 )	Gnanaraj J....Hashmi S.K.	2018
5	Anorexia nervosa-associated pancytopenia mimicking idiopathic aplastic anemia: a case report. ( 29801443 )	Takeshima M....Shimizu T.	2018
6	Pancytopenia in a young girl with skin lesions. ( 29380733 )	Bhavya S.K....Rakul N.	2018
7	Diagnosis of GATA2 haplo-insufficiency in a young woman prompted by pancytopenia with deficiencies of B-cell and dendritic cell development. ( 29588856 )	Sanyi A....Waller E.K.	2018
8	Fetal Hydrops Secondary to in utero Pancytopenia. ( 29972823 )	Berman D.R....Treadwell M.C.	2018
9	Nivolumab-induced severe pancytopenia in a patient with lung adenocarcinoma. ( 29656748 )	Tokumo K....Hattori N.	2018
10	Methotrexate-induced pancytopenia in a patient with ectopic pregnancy. ( 29593825 )	Shao S.C....Lai E.C.	2018
11	Severe pancytopenia and splenomegaly associated with felty's syndrome, both fully responsive solely to corticosteroids. ( 29531729 )	Liatsos G.D....Dourakis S.	2018
12	SAMD9 and SAMD9L in inherited predisposition to ataxia, pancytopenia, and myeloid malignancies. ( 29535429 )	Davidsson J....Cammenga J.	2018
13	Canine pancytopenia in the Mediterranean - Authors' reply. ( 29726020 )	Frezoulis P.S....Mylonakis M.E.	2018
14	CD41 immune staining of micromegakaryocytes improves the diagnosis of myelodysplastic syndrome and differentiation from pancytopenia. ( 29353154 )	Huang J....Zheng M.	2018
15	Fatal pancytopenia due to albendazole treatment for strongyloidiasis. ( 29942764 )		2018
16	Systemic lupus erythematosus presenting to haematology with pancytopenia and features of macrophage activation syndrome. ( 29467122 )		2018
17	Pancytopenia in an adult patient with thiamine-responsive megaloblastic anaemia. ( 29903777 )		2018
18	The Simplest Explanation: Pancytopenia. ( 29649461 )		2018
19	Levetiracetam Adverse Drug Reaction: Pancytopenia. ( 29899787 )		2018
20	Corrigendum to 'CD41 immune staining of micromegakaryocytes improves the diagnosis of myelodysplastic syndrome and differentiation from pancytopenia' [leukemia research. 2018; 66: 15-19]. ( 29673488 )		2018
21	Pancytopenia and Myelodysplastic Changes in Aceruloplasminemia: A Case with a Novel Pathogenic Variant in the Ceruloplasmin Gene. ( 29434149 )		2018
22	Pancytopenia and megaloblastic erythropoiesis reveal a novel GIF mutation. ( 29368379 )		2018
23	Probable fidaxomicin-induced pancytopenia. ( 29626003 )		2018
24	Lamotrigine-induced pancytopenia in bipolar disorder. ( 30033033 )	Chang CF...Chung KH	2018
25	Newly diagnosed AIDS with neurosyphilis, Kaposi sarcoma, pancytopenia, oropharyngeal candidiasis, and pseudomonal pneumonia: We shouldn't be seeing this anymore. ( 30101071 )	Yunina DS...Hecht M	2018
26	Pancytopenia: a rare complication of Graves' disease. ( 29525760 )	Garla VV...Yanes-Cardozo LL	2018
27	Unusual cause of infant pancytopenia: granulomatous bone marrow lesion with disseminated histoplasmosis. ( 29519931 )	Li W...Sharma M	2018
28	A rare and serious cause of pancytopenia in a patient with systemic lupus erythematosus: haemophagocytic lymphohistiocytosis. ( 30262544 )	Almuwaqqat Z...Bashtawi Y	2018
29	Unexplained pancytopenia in acute myeloid leukemia treatment. ( 30147892 )	Ezekwudo D...Kuriakose P	2018
30	Answer to Photo Quiz: Pancytopenia in a young girl with skin lesions. ( 29380734 )		2018
31	Reversible pancytopenia caused by severe copper deficiency in a patient with Wilson disease. ( 29954304 )	Mohamed M...Sharma A	2018
32	Azathioprine-induced pancytopenia with normal TPMT activity presenting with HSV oral ulcers. ( 30002211 )	Jensen CH...Catalanotti JS	2018
33	A Rare Cause of Pancytopenia in an Exclusively Breastfed Infant. ( 30028821 )	Bobb-Semple AA...Wistinghausen B	2018
34	Linezolid-induced pancytopenia. ( 30054325 )	Leader R...Carter P	2018
35	How should we manage low-dose methotrexate-induced pancytopenia in patients with rheumatoid arthritis? ( 30056523 )	Cansu D?...Korkmaz C	2018
36	Graves Disease Causing Pancytopenia: Case Report and Literature Review. ( 30083058 )	Pincet L...Gorostidi F	2018
37	Vitamin B12 deficiency presenting with hyperpigmentation and pancytopenia. ( 30112325 )	Rao VR	2018
38	Bovine Neonatal Pancytopenia-Associated Alloantibodies Recognize Individual Bovine Leukocyte Antigen 1 Alleles. ( 30154800 )	Kasonta R...Bastian M	2018
39	Case 28-2018: A 39-Year-Old Man with Epistaxis, Pain and Erythema of the Forearm, and Pancytopenia. ( 30207921 )	Iyasere CA...Siegele BJ	2018
40	Novel 1.3 Mb germline duplication in chromosome 8q21.11 by microarray comparative genomic hybridization plus single nucleotide polymorphism analysis in an adult patient with pancytopenia and urinary bladder complications. ( 30349704 )	Reyes Barron C...Iqbal MA	2018
41	Renal failure and progressive pancytopenia. ( 30488885 )	Yeo JH...Islam A	2018
42	Azathioprine-Induced Pancytopenia and Septic Complications: A Probable Cause of Death. ( 28874083 )	Panda B.K....Diwan A.	2017
43	Unusual case of splenomegaly and pancytopenia in a returned traveller. ( 29105271 )	Alcheikh A....Bryant C.	2017
44	Smear Campaign: Misattribution of Pancytopenia to a Tick-Borne Illness. ( 29273895 )	Lee J....Yialamas M.A.	2017
45	Screening novel autoantigens targeted by serum IgG autoantibodies in immunorelated pancytopenia by SEREX. ( 28687989 )	Hao S....Shao Z.	2017
46	A Howling Cause of Pancytopenia. ( 29069118 )	Casciato A....Davis A.M.	2017
47	Fever and Pancytopenia in a Liver Transplant Recipient: Going Against the Rules of Occam's Razor. ( 28706972 )	Lum L.H.W....Davis R.J.	2017
48	IVIG-Associated Maternal Pancytopenia during Treatment for Neonatal Alloimmune Thrombocytopenia. ( 28970962 )	Herrmann A....Samelson R.	2017
49	Successful haploidentical BMT with post-transplant cyclophosphamide for refractory autoimmune pancytopenia after cord blood transplant in pediatric myelodysplastic syndrome. ( 28067878 )	Shima H....Shimada H.	2017
50	Mutations in EFL1, an SBDS partner, are associated with infantile pancytopenia, exocrine pancreatic insufficiency and skeletal anomalies in aShwachman-Diamond like syndrome. ( 28331068 )	Stepensky P....Elpeleg O.	2017

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Genes for Pancytopenia

Genes related to Pancytopenia (0 elite genes):

(show all 17)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	SAMD9L	Sterile Alpha Motif Domain Containing 9 Like	Protein Coding	49.27	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
2	TPMT	Thiopurine S-Methyltransferase	Protein Coding	30.46	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	11037857 12172211 12454589 (more) 16995868 18520612 12477776
3	EPO	Erythropoietin	Protein Coding	29.29	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	1625496 8244908 17118765 (more) 10081639 9028164 9019832 8701705 9469507 9669693 1545564
4	DKC1	Dyskerin Pseudouridine Synthase 1	Protein Coding	28.94	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	11491307
5	TERT	Telomerase Reverse Transcriptase	Protein Coding	28.26	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
6	CSF2	Colony Stimulating Factor 2	Protein Coding	27.84	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	7680523 8283365
7	DHFR	Dihydrofolate Reductase	Protein Coding	27.27	Novoseek inferred ⁵⁵ GeneCards inferred via : Disorders Publications (show sections)	2353761
8	CSF1	Colony Stimulating Factor 1	Protein Coding	25.33	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	1625496 8460579 10081639
9	MPL	MPL Proto-Oncogene, Thrombopoietin Receptor	Protein Coding	23.43	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	20125166 16470591 15958695 (more) 11133753
10	CSF3	Colony Stimulating Factor 3	Protein Coding	23.32	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	1384817 17039083 11680980 (more) 9535034 17118765 18541787 1378668 7545637 8767533 9154449 20094735 7670408 7683451 9293906 7680523 11361215 9669693 9028164 7519041 20190483 10081639 9092691 7536347 12858207 7504385 12609794 17505274
11	THPO	Thrombopoietin	Protein Coding	23.31	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	11895799 9207438 12694260 (more) 10530413 19630808 9293906
12	TCN2	Transcobalamin 2	Protein Coding	22.44	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	2309761
13	MGMT	O-6-Methylguanine-DNA Methyltransferase	Protein Coding	22.36	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	19037596 8552605
14	SH2D1A	SH2 Domain Containing 1A	Protein Coding	21.99	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
15	LIG4	DNA Ligase 4	Protein Coding	21.79	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
16	IL3	Interleukin 3	Protein Coding	21.61	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	8273363 2048562 8292809 (more) 9373197 17312671
17	CD55	CD55 Molecule (Cromer Blood Group)	Protein Coding	21.52	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	15103939

Sources

Variations for Pancytopenia

Sources

Expression for Pancytopenia

Search GEO for disease gene expression data for Pancytopenia.

Sources

Pathways for Pancytopenia

Pathways related to Pancytopenia according to GeneCards Suite gene sharing:

(show all 14)

#	Super pathways	Score	Top Affiliating Genes
1	PI3K-Akt signaling pathway ³⁷ Show member pathways Human papillomavirus infection ³⁷	12.76	CSF1 CSF3 EPO IL3 TERT
2	JAK-STAT signaling pathway (KEGG) ³⁷ Show member pathways Interleukin-19, 20, 22, 24 ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵	12.16	CSF2 CSF3 EPO IL3 MPL THPO
3	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶⁴ Interferon alpha/beta signaling ⁶⁶ Regulation of IFNA signaling ⁶⁶	12.02	DKC1 IL3 TERT THPO
4	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.84	IL3 TERT THPO
5	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.56	CSF1 CSF2 CSF3 EPO IL3 MPL
6	Lung fibrosis ¹	11.43	CSF2 CSF3 TERT
7	Interleukin-10 signaling ⁶⁶	11.27	CSF1 CSF2 CSF3
8	Differentiation Pathway ¹	11.23	CSF1 EPO IL3
9	Hematopoietic Stem Cell Differentiation ¹	11.23	CSF1 CSF2 CSF3 EPO IL3
10	Hematopoietic cell lineage ³⁷	11.15	CD55 CSF1 CSF2 CSF3 EPO IL3
11	Cytokines and Inflammatory Response ¹	11.02	CSF1 CSF2 CSF3 IL3
12	G-protein signaling_RhoB regulation pathway ²²	10.96	CSF1 CSF2 CSF3 IL3
13	G-protein signaling_Rap2B regulation pathway ²²	10.78	CSF1 CSF2 CSF3 IL3 THPO
14	Development of pulmonary dendritic cells and macrophage subsets ¹	10.61	CSF1 CSF2

Sources

GO Terms for Pancytopenia

Cellular components related to Pancytopenia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.7	CSF1 CSF2 CSF3 EPO IL3 TCN2
2	extracellular region	GO:0005576	9.23	CD55 CSF1 CSF2 CSF3 EPO IL3
3	telomerase holoenzyme complex	GO:0005697	8.96	DKC1 TERT

Biological processes related to Pancytopenia according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell proliferation	GO:0008284	9.73	CSF1 CSF2 CSF3 EPO IL3 THPO
2	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.58	CSF2 EPO IL3
3	cytokine-mediated signaling pathway	GO:0019221	9.55	CSF1 CSF2 CSF3 IL3 MPL
4	telomere maintenance via telomerase	GO:0007004	9.49	DKC1 TERT
5	positive regulation of nitric-oxide synthase activity	GO:0051000	9.48	DHFR TERT
6	positive regulation of Ras protein signal transduction	GO:0046579	9.46	CSF1 EPO
7	positive regulation of macrophage derived foam cell differentiation	GO:0010744	9.43	CSF1 CSF2
8	regulation of signaling receptor activity	GO:0010469	9.43	CSF1 CSF2 CSF3 EPO IL3 THPO
9	DNA ligation	GO:0006266	9.37	LIG4 MGMT
10	thrombopoietin-mediated signaling pathway	GO:0038163	9.32	MPL THPO
11	cell proliferation	GO:0008283	9.1	CSF1 DKC1 EPO LIG4 MPL THPO

Molecular functions related to Pancytopenia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	growth factor activity	GO:0008083	9.35	CSF1 CSF2 CSF3 IL3 THPO
2	telomerase RNA binding	GO:0070034	9.26	DKC1 TERT
3	telomerase activity	GO:0003720	9.16	DKC1 TERT
4	cytokine activity	GO:0005125	9.1	CSF1 CSF2 CSF3 EPO IL3 THPO

Sources

Sources for Pancytopenia

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia