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MCID: PNC001
MIFTS: 51

Pancytopenia

Categories: Blood diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Pancytopenia

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MalaCards integrated aliases for Pancytopenia:

Name: Pancytopenia 12 29 55 44 15 73

Classifications:

MalaCards categories:
Anatomical: Blood diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:12450
ICD10 33 D61.81
ICD9CM 35 284.1
MeSH 44 D010198
UMLS 73 C0030312
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Summaries for Pancytopenia

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Disease Ontology : 12 An anemia that is characterized by a reduction in the number of red blood cells, white blood cells, and platelets.

MalaCards based summary : Pancytopenia is related to dyskeratosis congenita and amegakaryocytic thrombocytopenia, congenital. An important gene associated with Pancytopenia is SAMD9L (Sterile Alpha Motif Domain Containing 9 Like), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Regulation of IFNA signaling. The drugs Benzocaine and Lenograstim have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and t cells, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 Pancytopenia is a medical condition in which there is a reduction in the number of red and white blood... more...

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Related Diseases for Pancytopenia

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Diseases related to Pancytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 336)
# Related Disease Score Top Affiliating Genes
1 dyskeratosis congenita 31.7 CSF2 CSF3 DKC1 LIG4 TERT
2 amegakaryocytic thrombocytopenia, congenital 31.2 IL3 MPL THPO
3 splenomegaly 30.4 EPO MPL
4 diamond-blackfan anemia 29.2 CSF2 EPO IL3 MPL THPO
5 myeloma, multiple 29.2 CSF2 CSF3 EPO LIG4
6 severe congenital neutropenia 29.1 CSF2 CSF3 IL3
7 refractory anemia 29.0 EPO IL3 MPL
8 thrombocytopenia 28.8 CSF3 MPL THPO
9 deficiency anemia 28.5 CSF3 EPO IL3 THPO
10 malaria 28.2 CSF2 CSF3 DHFR EPO TCN2
11 neutropenia 28.0 CSF2 CSF3 EPO IL3 THPO
12 myelofibrosis 28.0 CSF3 EPO IL3 MPL THPO
13 polycythemia 27.9 EPO IL3 MPL THPO
14 polycythemia vera 27.9 EPO IL3 MPL THPO
15 aplastic anemia 27.4 CSF1 CSF2 CSF3 DKC1 EPO IL3
16 thrombocytosis 27.3 CSF2 EPO IL3 MPL THPO
17 leukemia, acute myeloid 26.9 CSF2 CSF3 IL3 MPL SAMD9L TERT
18 leukemia, chronic myeloid 26.8 CSF2 CSF3 EPO IL3 MPL THPO
19 myelodysplastic syndrome 26.3 CSF1 CSF2 CSF3 EPO IL3 MPL
20 ataxia-pancytopenia syndrome 12.4
21 samd9l-related ataxia-pancytopenia syndrome 12.0
22 pancytopenia and occlusive vascular disease 11.9
23 fanconi anemia, complementation group a 11.9
24 dyskeratosis congenita, x-linked 11.3
25 fanconi anemia, complementation group c 11.1
26 fanconi anemia, complementation group d2 11.1
27 fanconi anemia, complementation group b 11.1
28 hemophagocytic lymphohistiocytosis 11.1
29 fanconi-like syndrome 11.1
30 sackey sakati aur syndrome 11.0
31 radioulnar synostosis with amegakaryocytic thrombocytopenia 2 10.9
32 bone marrow failure syndrome 3 10.9
33 cerebroretinal microangiopathy with calcifications and cysts 2 10.9
34 bone marrow failure syndrome 2 10.8
35 immunodeficiency, common variable, 13 10.8
36 evans' syndrome 10.8
37 osteopetrosis, autosomal dominant 2 10.7
38 gaucher disease, type iii 10.7
39 methylmalonyl-coa epimerase deficiency 10.7
40 osteopetrosis, autosomal recessive 1 10.7
41 osteopetrosis, autosomal recessive 2 10.7
42 osteopetrosis, autosomal recessive 5 10.7
43 osteopetrosis, autosomal recessive 3 10.7
44 transcobalamin ii deficiency 10.7
45 lymphoproliferative syndrome, x-linked, 2 10.7
46 lymphoproliferative syndrome, x-linked, 1 10.7
47 hemophagocytic lymphohistiocytosis, familial, 2 10.7
48 radioulnar synostosis with amegakaryocytic thrombocytopenia 1 10.7
49 transaldolase deficiency 10.7
50 lig4 syndrome 10.7

Graphical network of the top 20 diseases related to Pancytopenia:



Diseases related to Pancytopenia
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Symptoms & Phenotypes for Pancytopenia

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MGI Mouse Phenotypes related to Pancytopenia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.25 LIG4 CSF2 CSF3 MPL DHFR RAB27A
2 homeostasis/metabolism MP:0005376 10.21 LIG4 CSF2 MGMT MPL DHFR RAB27A
3 immune system MP:0005387 10.13 LIG4 CSF2 CSF3 MPL DHFR RAB27A
4 mortality/aging MP:0010768 9.9 EPO CSF1 LIG4 CSF2 MGMT MPL
5 integument MP:0010771 9.86 EPO CSF1 CSF2 CSF3 DHFR RAB27A
6 neoplasm MP:0002006 9.43 LIG4 CSF2 MGMT DKC1 TERT SAMD9L
7 respiratory system MP:0005388 9.17 EPO CSF1 CSF2 MGMT RAB27A DKC1
Sources

Drugs & Therapeutics for Pancytopenia

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Drugs for Pancytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 229)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved, Investigational Phase 4,Phase 2 1994-09-7, 94-09-7 2337
2
Lenograstim Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 135968-09-1
3
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 1 53-03-2 5865
4
Busulfan Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 55-98-1 2478
5
Fludarabine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 21679-14-1, 75607-67-9 30751
6
Oprelvekin Approved, Investigational Phase 4 145941-26-0
7
Peginterferon alfa-2a Approved, Investigational Phase 4 198153-51-4 5360545
8
Ribavirin Approved Phase 4 36791-04-5 37542
9
Pantoprazole Approved Phase 4 102625-70-7 4679
10
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
11
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
12
Ticlopidine Approved Phase 4 55142-85-3 5472
13
Menthol Approved Phase 4,Not Applicable 2216-51-5 16666
14
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
15
Haloperidol Approved Phase 4 52-86-8 3559
16 tannic acid Approved, Nutraceutical Phase 4,Phase 2
17
Treosulfan Investigational Phase 4,Phase 2 299-75-2 9296
18 Cyclosporins Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 Immunosuppressive Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
20 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
21 Antimetabolites Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
22 Antiviral Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
23 Protective Agents Phase 4,Phase 2,Phase 1
24 Alkylating Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
25 Antineoplastic Agents, Alkylating Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
26 decanoic acid Phase 4,Phase 1,Phase 2
27 Antilymphocyte Serum Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Interferon-alpha Phase 4
29 interferons Phase 4
30 Antacids Phase 4
31 Anti-Ulcer Agents Phase 4
32 Gastrointestinal Agents Phase 4,Phase 2,Phase 1,Not Applicable
33 Proton Pump Inhibitors Phase 4
34 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
35 Neuroprotective Agents Phase 4,Phase 2,Phase 1
36 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
37 Respiratory System Agents Phase 4,Phase 3
38 Antiemetics Phase 4,Phase 2,Phase 1
39 Anti-Asthmatic Agents Phase 4
40 Bronchodilator Agents Phase 4
41 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 1
42 Fibrinolytic Agents Phase 4
43 Neurotransmitter Agents Phase 4
44 Phosphodiesterase 3 Inhibitors Phase 4
45 Phosphodiesterase Inhibitors Phase 4
46 Platelet Aggregation Inhibitors Phase 4
47 Purinergic P2 Receptor Antagonists Phase 4
48 Purinergic P2Y Receptor Antagonists Phase 4
49 Vasodilator Agents Phase 4
50 Antipsychotic Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 176)
# Name Status NCT ID Phase Drugs
1 Different Doses of Anti-thymocyte Globin to Treat Child Severe Aplastic Anemia Unknown status NCT01997372 Phase 4 ATG
2 Effect of rhIL-11 in Patients With Thrombocytopenia for Childhood ALL Completed NCT02314273 Phase 4 rhIL-11
3 A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) Plus COPEGUS (Ribavirin) in Patients With Chronic Hepatitis C (CHC) Genotype 1 and Human Immunodeficiency Virus-1 (HIV-1) Co-infection Completed NCT00353418 Phase 4 Peginterferon alfa-2a;Ribavirin;Ribavirin
4 Stress Ulcer Prophylaxis in the Intensive Care Unit Completed NCT02467621 Phase 4 Pantoprazole
5 Diabetic Artery Obstruction: is it Possible to Reduce Ischemic Events With Cilostazol? Recruiting NCT02983214 Phase 4 Clopidogrel;Cilostazol
6 ALL SCTped FORUM - Pharmacogenomic Study (add-on Study) Recruiting NCT02670564 Phase 4
7 Agents Intervening Against Delirium in Intensive Care Unit Recruiting NCT03392376 Phase 4 Haloperidol Injection
8 Eltrombopag in Children With Idiopathic Aplastic Anemia Not yet recruiting NCT03243656 Phase 4 Eltrombopag
9 The Impact of Red Cell Age on Product Utilization in the Chronically Transfused Outpatient Population Unknown status NCT02393508 Phase 3
10 Risk-Adapted Allogeneic Stem Cell Transplantation For Mixed Donor Chimerism In Patients With Non-Malignant Diseases Unknown status NCT01019876 Phase 2, Phase 3 Fludarabine;Cyclophosphamide;Cyclophosphamide 40;Cyclophosphamide 30
11 Erythropoietin (EPO) and Granulocyte-Colony Stimulating Factor (G-CSF) for Low-Risk Myelodysplastic Syndromes (MDS) Unknown status NCT00234143 Phase 2, Phase 3 Darbepoetin
12 Comparison of Cy-Atg vs Flu-Atg for the Conditioning Therapy in Allo-HCT for Adult Aplastic Anemia Unknown status NCT01145976 Phase 3 Cy-ATG;Flu-ATG
13 Stem Cell Transplant for Bone Marrow Failure Syndromes Completed NCT00176878 Phase 2, Phase 3 Fludarabine monophosphate;Busulfan
14 Comparison of Cy-Atg Vs Cy-Flu-Atg for the Conditioning Therapy in Allo-HCT Completed NCT00774527 Phase 3 Cyclophosphamide-fludarabine-anti thymocyte globulin
15 Cyclosporine Eye Drops in Preventing Graft-Versus-Host Disease of the Eye in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer or Bone Marrow Failure Disorder Completed NCT00755040 Phase 3 cyclosporine ophthalmic emulsion
16 Multi-Center Trial of Anti-Thymocyte Globulin in Treatment of Aplastic Anemia and Other Hematologic Disorders Completed NCT00000597 Phase 3 antilymphocyte serum;nandrolone
17 Eculizumab to Treat Paroxysmal Nocturnal Hemoglobinuria Completed NCT00098280 Phase 3 Eculizumab
18 Maribavir Versus Oral Ganciclovir For The Prevention of Cytomegalovirus (CMV) Disease in Liver Transplant Recipients Completed NCT00497796 Phase 3 maribavir;ganciclovir
19 A Study of MK-3415, MK-6072, and MK-3415A in Participants Receiving Antibiotic Therapy for Clostridium Difficile Infection (MK-3415A-001) Completed NCT01241552 Phase 3 SOC
20 A Study of MK-6072 and MK-3415A in Participants Receiving Antibiotic Therapy for Clostridium Difficile Infection (MK-3415A-002) Completed NCT01513239 Phase 3 SOC
21 A Study Evaluating Epoetin Alfa 40,000 IU (International Units) Every Week or 80,000 IU Every Week Compared to Placebo in Patients With Low or Intermediate-1 Risk Myelodysplastic Syndromes at Risk for Transfusion Terminated NCT00695396 Phase 3 Placebo;Epoetin alfa;Placebo;Epoetin alfa
22 Safety and Efficacy of Levamisole Combined With Cyclosporine A in Patients With Subclinical Paroxysmal Nocturnal Hemoglobinuria and PNH in the Setting of Another Bone Marrow Failure Syndromes(PNH-2013) Unknown status NCT01760096 Phase 2 Levamisole+cyclosporin A+Glucocorticoids;cyclosporin A+Glucocorticoids;Glucocorticoids
23 Limiting Chemotherapy Side Effects by Using Moxa Unknown status NCT02781155 Phase 1, Phase 2
24 Nandrolone Decanoate in the Treatment of Telomeropathies Unknown status NCT02055456 Phase 1, Phase 2 Nandrolone Decanoate
25 Eltrombopag for Enhancing Platelet Engraftment in Adult Patients Undergoing Cord Blood Transplantation Unknown status NCT01757145 Phase 2 Eltrombopag
26 A Single-Arm Phase 2 Study With Optimized Standard Protocol for Severe Aplastic Anemia Unknown status NCT02203396 Phase 2 rabbit ATG, Cyclosporine, Levamisole
27 Safety and Efficacy of Levamisole Combined With Cyclosporine A in Patients With Classic Paroxysmal Nocturnal Hemoglobinuria Unknown status NCT01642979 Phase 2 Levamisole+cyclosporin A+Glucocorticoids;cyclosporin A+Glucocorticoids;Glucocorticoids
28 Rabbit Antithymocyte Globulin Versus Campath-1H for Treating Severe Aplastic Anemia Completed NCT00065260 Phase 2 Campath-1H;r-ATG;CsA
29 Donor Stem Cell Transplant After Busulfan, Fludarabine, Methylprednisolone, and Antithymocyte Globulin in Treating Patients With Bone Marrow Failure Syndrome Completed NCT00731328 Phase 2
30 Allogeneic Mixed Chimerism Stem Cell Transplant Using Campath for Hemoglobinopathies & Bone Marrow Failure Syndromes Completed NCT00004143 Phase 2 Campath, Chemo and/or TBI Allo SCT
31 Three Immunosuppressive Treatment Regimens for Severe Aplastic Anemia Completed NCT00260689 Phase 2 Cyclosporine;Alemtuzumab
32 Cyclophosphamide Plus Cyclosporine in Treatment-Naive Severe Aplastic Anemia Completed NCT01193283 Phase 1, Phase 2 Cyclophosphamide;Cyclosporine
33 Phase II Pilot Study of Granulocyte Colony-Stimulating Factor for Inherited Bone Marrow Failure Syndromes Completed NCT00004787 Phase 2 filgrastim
34 A Pilot Study of Fludarabine Plus Cyclophosphamide in Refractory Severe Aplastic Anemia Completed NCT01187017 Phase 1, Phase 2 Cyclophosphamide;Fludarabine
35 Reduced Intensity Conditioning Using CD3+/CD19+ Depletion for Non Malignant Transplantable Diseases Completed NCT02277639 Phase 2
36 Improving Immunosuppressive Treatment for Patients With Severe Aplastic Anemia Completed NCT00061360 Phase 2 Sirolimus (Rapamune)
37 Chemotherapy, Radiation Therapy, and Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003270 Phase 2 busulfan;cyclophosphamide;cyclosporine;methylprednisolone
38 Bone Marrow Transplant Plus Cyclophosphamide and Total-Body Irradiation in Treating Patients With Hematologic Cancer Completed NCT00002809 Phase 2 cyclophosphamide;methotrexate;tacrolimus
39 Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer or Other Hematologic or Metabolic Diseases Completed NCT00003662 Phase 2 busulfan;cyclophosphamide;cyclosporine;melphalan;methylprednisolone
40 Bortezomib to Treat Significant Complication of HSCT Completed NCT01929980 Phase 2 Bortezomib
41 Danazol for Genetic Bone Marrow and Lung Disorders Completed NCT01441037 Phase 1, Phase 2 Danazol
42 Mobilization and Collection of Peripheral Blood Stem Cells in Patients With Fanconi Anemia Using G-CSF and AMD3100 Completed NCT00479115 Phase 1, Phase 2 AMD3100
43 Rituximab to Treat Moderate Aplastic Anemia, Pure Red Cell Aplasia, or Diamond Blackfan Anemia Completed NCT00229619 Phase 2 Rituximab
44 Doxercalciferol in Treating Patients With Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia Completed NCT00052832 Phase 2
45 High-Dose Immunosuppression and Autologous Transplantation for Multiple Sclerosis (HALT MS) Study Completed NCT00288626 Phase 2 Granulocyte-colony stimulating factor (G-CSF) and prednisone;Carmustine, etoposide, cytarabine, and melphalan (BEAM)
46 Antithymocyte Globulin and Cyclosporine to Treat Myelodysplasia Completed NCT00005937 Phase 2 Antithymocyte globulin;Cyclosporine
47 Study of the Efficacy and Safety of Lenalidomide in Combination With Cyclosporine A in Patients With Myelodysplastic Syndromes Completed NCT00840827 Phase 2 lenalidomide;cyclosporine A
48 Comparing Three Different Combination Chemotherapy Regimens in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia Completed NCT00634244 Phase 2 alvocidib;mitoxantrone hydrochloride;carboplatin;cytarabine;sirolimus;etoposide;topotecan hydrochloride
49 Horse ATG/CsA in Aplastic Anemia Patients Unresponsive to or With a Suboptimal Response to Rabbit ATG/CsA Treatment Completed NCT00944749 Phase 2 h-ATG (ATGAM );Cyclosporine (Gengraf )
50 Mobilization of Stem Cells With G-CSF for Collection From Patients With Diamond-Blackfan Anemia Completed NCT00011505 Phase 2 G-CSF

Search NIH Clinical Center for Pancytopenia

Cochrane evidence based reviews: pancytopenia

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Genetic Tests for Pancytopenia

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Genetic tests related to Pancytopenia:

# Genetic test Affiliating Genes
1 Pancytopenia 29
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Anatomical Context for Pancytopenia

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MalaCards organs/tissues related to Pancytopenia:

41
Bone, Bone Marrow, T Cells, Myeloid, Liver, Lung, B Cells
Sources

Publications for Pancytopenia

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Articles related to Pancytopenia:

(show top 50) (show all 733)
# Title Authors Year
1
Fever with pancytopenia: unusual presentation of extrapulmonary tuberculosis: a case report. ( 29506574 )
2018
2
Visceral leishmaniasis presenting with pancytopenia and circulating blastlike lymphocytes. ( 29930152 )
2018
3
Ecthyma Gangrenosum: Vulvar Ulcers, Pseudomonas and Pancytopenia, A Case Report of an 18- Month-Old Female. ( 29885367 )
2018
4
Approach to pancytopenia: Diagnostic algorithm for clinical hematologists. ( 29555368 )
2018
5
Anorexia nervosa-associated pancytopenia mimicking idiopathic aplastic anemia: a case report. ( 29801443 )
2018
6
Pancytopenia in a young girl with skin lesions. ( 29380733 )
2018
7
Diagnosis of GATA2 haplo-insufficiency in a young woman prompted by pancytopenia with deficiencies of B-cell and dendritic cell development. ( 29588856 )
2018
8
Fetal Hydrops Secondary to in utero Pancytopenia. ( 29972823 )
2018
9
Nivolumab-induced severe pancytopenia in a patient with lung adenocarcinoma. ( 29656748 )
2018
10
Methotrexate-induced pancytopenia in a patient with ectopic pregnancy. ( 29593825 )
2018
11
Severe pancytopenia and splenomegaly associated with felty's syndrome, both fully responsive solely to corticosteroids. ( 29531729 )
2018
12
SAMD9 and SAMD9L in inherited predisposition to ataxia, pancytopenia, and myeloid malignancies. ( 29535429 )
2018
13
Canine pancytopenia in the Mediterranean - Authors' reply. ( 29726020 )
2018
14
CD41 immune staining of micromegakaryocytes improves the diagnosis of myelodysplastic syndrome and differentiation from pancytopenia. ( 29353154 )
2018
15
Fatal pancytopenia due to albendazole treatment for strongyloidiasis. ( 29942764 )
2018
16
Systemic lupus erythematosus presenting to haematology with pancytopenia and features of macrophage activation syndrome. ( 29467122 )
2018
17
Pancytopenia in an adult patient with thiamine-responsive megaloblastic anaemia. ( 29903777 )
2018
18
The Simplest Explanation: Pancytopenia. ( 29649461 )
2018
19
Levetiracetam Adverse Drug Reaction: Pancytopenia. ( 29899787 )
2018
20
Corrigendum to 'CD41 immune staining of micromegakaryocytes improves the diagnosis of myelodysplastic syndrome and differentiation from pancytopenia' [leukemia research. 2018; 66: 15-19]. ( 29673488 )
2018
21
Pancytopenia and Myelodysplastic Changes in Aceruloplasminemia: A Case with a Novel Pathogenic Variant in the Ceruloplasmin Gene. ( 29434149 )
2018
22
Pancytopenia and megaloblastic erythropoiesis reveal a novel GIF mutation. ( 29368379 )
2018
23
Probable fidaxomicin-induced pancytopenia. ( 29626003 )
2018
24
Answer to Photo Quiz: Pancytopenia in a young girl with skin lesions. ( 29380734 )
2018
25
Reversible pancytopenia caused by severe copper deficiency in a patient with Wilson disease. ( 29954304 )
2018
26
Azathioprine-Induced Pancytopenia and Septic Complications: A Probable Cause of Death. ( 28874083 )
2017
27
Unusual case of splenomegaly and pancytopenia in a returned traveller. ( 29105271 )
2017
28
Smear Campaign: Misattribution of Pancytopenia to a Tick-Borne Illness. ( 29273895 )
2017
29
Screening novel autoantigens targeted by serum IgG autoantibodies in immunorelated pancytopenia by SEREX. ( 28687989 )
2017
30
A Howling Cause of Pancytopenia. ( 29069118 )
2017
31
Fever and Pancytopenia in a Liver Transplant Recipient: Going Against the Rules of Occam's Razor. ( 28706972 )
2017
32
IVIG-Associated Maternal Pancytopenia during Treatment for Neonatal Alloimmune Thrombocytopenia. ( 28970962 )
2017
33
Successful haploidentical BMT with post-transplant cyclophosphamide for refractory autoimmune pancytopenia after cord blood transplant in pediatric myelodysplastic syndrome. ( 28067878 )
2017
34
Mutations in EFL1, an SBDS partner, are associated with infantile pancytopenia, exocrine pancreatic insufficiency and skeletal anomalies in aShwachman-Diamond like syndrome. ( 28331068 )
2017
35
Pembrolizumab-Induced Pancytopenia: A Case Report. ( 28746020 )
2017
36
Case 20-2017 - A 48-Year-Old Man with Weight Loss, Confusion, Skin Lesions, and Pancytopenia. ( 28657866 )
2017
37
A Young Woman With an Erythematous Rash, Fever, Tachycardia, and Pancytopenia. ( 28654467 )
2017
38
Pancytopenia and Fever of Unknown Origin in a 12-Year-Old Boy. ( 29073781 )
2017
39
Plasmablastic light chain myeloma presenting as pancytopenia: An unusual presentation. ( 29916426 )
2017
40
Case report: patient with unexplained high fever and pancytopenia. ( 28521652 )
2017
41
Suspected immune-mediated neutropenia and corticosteroid responsive pancytopenia in a Portuguese water dog. ( 28042161 )
2017
42
Clinicohematological Study of Pancytopenia in a Tertiary Care Hospital of Western Region of Nepal. ( 29255313 )
2017
43
Herd-level animal management factors associated with the occurrence of bovine neonatal pancytopenia in calves in a multi-country study. ( 28678850 )
2017
44
Chilblain lupus and steroid-responsive pancytopenia precede monosomy 7-linked AML as manifestation of rasopathy. ( 28802089 )
2017
45
The risks of using allogeneic cell lines for vaccine production: the example of Bovine Neonatal Pancytopenia. ( 27744721 )
2017
46
Mixed Malarial Infection with Pancytopenia in a Child with Acute Lymphoblastic Leukemia: An Unusual Presentation. ( 28469349 )
2017
47
Pancytopenia and Hypothyroidism in a Patient With Leukemic Infiltration of the Thyroid as the First Presentation of Acute Lymphoblastic Leukemia. ( 28562510 )
2017
48
Hypocobalaminaemia as a cause of bone marrow failure and pancytopenia in a cat. ( 28444757 )
2017
49
Gene expression signature for early prediction of late occurring pancytopenia in irradiated baboons. ( 28236054 )
2017
50
Case report: An HIV+ patient presenting with pancytopenia, hepatic failure, and coagulopathy; a rare small cell liver carcinoma with diffuse splenic and bone marrow metastasis diagnosed at autopsy. ( 28935394 )
2017
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Variations for Pancytopenia

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Expression for Pancytopenia

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Search GEO for disease gene expression data for Pancytopenia.
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Pathways for Pancytopenia

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Pathways related to Pancytopenia according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
PI3K-Akt signaling pathway 37
Show member pathways
 12.7 CSF1 CSF3 EPO IL3 TERT
2
Regulation of IFNA signaling 66
Show member pathways
 12.39 CSF2 CSF3 EPO IL3 MPL THPO
3
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.79 IL3 TERT THPO
4
Hematopoietic cell lineage 37
11.42 CSF1 CSF2 CSF3 EPO IL3 THPO
5
Lung fibrosis 1
11.41 CSF2 CSF3 TERT
6
Interleukin-10 signaling 66
11.27 CSF1 CSF2 CSF3
7
Differentiation Pathway 1
11.23 CSF1 EPO IL3
8
Hematopoietic Stem Cell Differentiation 1
11.23 CSF1 CSF2 CSF3 EPO IL3
9
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.23 CSF1 CSF2 CSF3 EPO IL3 MPL
10
Cytokines and Inflammatory Response 1
11.03 CSF1 CSF2 CSF3 IL3
11
Development of pulmonary dendritic cells and macrophage subsets 1
10.57 CSF1 CSF2
Sources

GO Terms for Pancytopenia

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Cellular components related to Pancytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 CSF1 CSF2 CSF3 EPO IL3 TCN2
2 extracellular region GO:0005576 9.23 CSF1 CSF2 CSF3 EPO IL3 RAB27A
3 telomerase holoenzyme complex GO:0005697 9.16 DKC1 TERT

Biological processes related to Pancytopenia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.83 CSF1 CSF2 CSF3 EPO IL3
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.58 CSF2 EPO IL3
3 cytokine-mediated signaling pathway GO:0019221 9.55 CSF1 CSF2 CSF3 IL3 MPL
4 telomere maintenance via telomerase GO:0007004 9.54 DKC1 TERT
5 positive regulation of Ras protein signal transduction GO:0046579 9.52 CSF1 EPO
6 positive regulation of nitric-oxide synthase activity GO:0051000 9.51 DHFR TERT
7 positive regulation of DNA replication GO:0045740 9.5 CSF2 EPO IL3
8 macrophage differentiation GO:0030225 9.49 CSF1 CSF3
9 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.48 CSF1 CSF2
10 DNA ligation GO:0006266 9.46 LIG4 MGMT
11 regulation of signaling receptor activity GO:0010469 9.43 CSF1 CSF2 CSF3 EPO IL3 THPO
12 neutrophil differentiation GO:0030223 9.37 CSF2 CSF3
13 thrombopoietin-mediated signaling pathway GO:0038163 9.26 MPL THPO
14 cell proliferation GO:0008283 9.1 CSF1 DKC1 EPO LIG4 MPL THPO

Molecular functions related to Pancytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.35 CSF1 CSF2 CSF3 IL3 THPO
2 telomerase RNA binding GO:0070034 9.26 DKC1 TERT
3 telomerase activity GO:0003720 9.16 DKC1 TERT
4 cytokine activity GO:0005125 9.1 CSF1 CSF2 CSF3 EPO IL3 THPO
Sources

Sources for Pancytopenia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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