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PANIC
MCID: PNC025
MIFTS: 56

Panic Disorder (PANIC)

Categories: Mental diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Panic Disorder

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MalaCards integrated aliases for Panic Disorder:

Name: Panic Disorder 12 76 37 55 43 44 15 73
Panic Anxiety Syndrome 12
Panic Disorder 1 73
Panic 55

Classifications:

MalaCards categories:
Anatomical: Mental diseases Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:594
ICD10 33 F41.0
MeSH 44 D016584
NCIt 50 C34890
KEGG 37 H01664
Sources

Summaries for Panic Disorder

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MedlinePlus : 43 Panic disorder is a type of anxiety disorder. It causes panic attacks, which are sudden feelings of terror when there is no real danger. You may feel as if you are losing control. You may also have physical symptoms, such as Fast heartbeat Chest or stomach pain Breathing difficulty Weakness or dizziness Sweating Feeling hot or a cold chill Tingly or numb hands Panic attacks can happen anytime, anywhere, and without warning. You may live in fear of another attack and may avoid places where you have had an attack. For some people, fear takes over their lives and they cannot leave their homes. Panic disorder is more common in women than men. It usually starts when people are young adults. Sometimes it starts when a person is under a lot of stress. Most people get better with treatment. Therapy can show you how to recognize and change your thinking patterns before they lead to panic. Medicines can also help. NIH: National Institute of Mental Health

MalaCards based summary : Panic Disorder, also known as panic anxiety syndrome, is related to panic disorder 1 and anxiety. An important gene associated with Panic Disorder is MIR22 (MicroRNA 22), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Serotonergic synapse. The drugs Paroxetine and Valproic Acid have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and testes, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : 12 An anxiety disorder that is characterized by unexpected and repeated episodes of intense fear accompanied by physical symptoms that may include chest pain, heart palpitations, shortness of breath, dizziness, or abdominal distress.

Wikipedia : 76 Panic disorder is an anxiety disorder characterized by reoccurring unexpected panic attacks. Panic... more...

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Related Diseases for Panic Disorder

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Diseases in the Panic Disorder family:

Panic Disorder 1 Panic Disorder 2
Panic Disorder 3

Diseases related to Panic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 202)
# Related Disease Score Top Affiliating Genes
1 panic disorder 1 34.5 COMT PAND1
2 anxiety 32.2 CCKBR COMT CRH HTR1A HTR2A HTR3A
3 agoraphobia 31.8 CCKBR HTR1A MAOA PTK7 SLC6A2 SLC6A4
4 phobic disorder 31.8 COMT HTR1A MAOA PTK7 SLC6A4
5 depression 31.4 CRH HTR1A HTR2A MAOA SLC6A4 TPH2
6 social phobia 31.2 CCK HTR1A HTR3A MAOA SLC6A4
7 personality disorder 31.0 COMT HTR1A HTR2A MAOA SLC6A4
8 alexithymia 30.9 COMT HTR1A SLC6A4
9 generalized anxiety disorder 30.9 COMT HTR1A HTR2A HTR3A MAOA SLC6A2
10 obsessive-compulsive disorder 30.8 COMT CRH HTR1A HTR2A HTR3A MAOA
11 major depressive disorder 30.7 COMT CRH HTR1A HTR2A HTR3A MAOA
12 irritable bowel syndrome 30.6 CCK CRH HTR3A SLC6A4
13 dysthymic disorder 30.5 HTR2A MAOA SLC6A4
14 endogenous depression 30.5 CRH HTR1A HTR2A MAOA SLC6A4
15 phobia, specific 30.4 COMT MAOA
16 post-traumatic stress disorder 30.4 COMT CRH HTR2A MAOA SLC6A4
17 eating disorder 30.4 CCK COMT CRH SLC6A4
18 borderline personality disorder 30.1 COMT HTR1A HTR2A MAOA SLC6A4 TPH2
19 atypical depressive disorder 30.1 CRH HTR2A MAOA SLC6A4
20 conduct disorder 30.1 COMT MAOA SLC6A4
21 bipolar disorder 30.0 COMT CRH DAOA-AS1 HTR1A HTR2A HTR3A
22 mood disorder 30.0 COMT CRH HTR1A HTR2A MAOA SLC6A2
23 tobacco addiction 30.0 COMT HTR2A MAOA SLC6A4
24 bipolar i disorder 30.0 COMT HTR1A HTR2A SLC6A4
25 cocaine abuse 30.0 HTR3A SLC6A2 SLC6A4
26 premature ejaculation 30.0 COMT HTR1A HTR3A SLC6A4
27 avoidant personality disorder 29.9 MAOA SLC6A4
28 bulimia nervosa 29.9 CCK COMT HTR2A HTR3A SLC6A4
29 dyspepsia 29.9 CCK CCKAR HTR1A HTR3A SLC6A4
30 schizoaffective disorder 29.9 COMT HTR2A SLC6A4
31 schizophrenia 29.8 CCK CCKAR COMT DAOA-AS1 HTR1A HTR2A
32 fibromyalgia 29.8 COMT CRH HTR2A HTR3A SLC6A4 TSPO
33 attention deficit-hyperactivity disorder 29.7 COMT HTR1A HTR2A MAOA SLC6A2 SLC6A4
34 psychotic disorder 29.7 COMT HTR1A HTR2A HTR3A SLC6A4
35 mental depression 29.7 COMT CRH HTR1A HTR2A MAOA SLC6A2
36 sudden infant death syndrome 29.6 HTR1A HTR2A HTR3A MAOA SLC6A4 TPH2
37 alcohol dependence 29.6 CCK COMT HTR1A HTR2A HTR3A MAOA
38 panic disorder 3 12.4
39 panic disorder 2 12.3
40 dystonia 11, myoclonic 11.0
41 cancerophobia 11.0
42 autoimmune encephalitis 11.0
43 misophonia 11.0
44 orthostatic intolerance 10.4
45 schizoid personality disorder 10.3 HTR1A HTR2A
46 kleptomania 10.3 HTR1A MAOA SLC6A4
47 separation anxiety disorder 10.3
48 pathological gambling 10.3 HTR2A MAOA SLC6A4
49 hypoactive sexual desire disorder 10.3 HTR1A HTR2A
50 antisocial personality disorder 10.3 COMT MAOA SLC6A4

Graphical network of the top 20 diseases related to Panic Disorder:



Diseases related to Panic Disorder
Sources

Symptoms & Phenotypes for Panic Disorder

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GenomeRNAi Phenotypes related to Panic Disorder according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.28 HTR1A HTR3A SLC6A4
2 Decreased viability GR00381-A-3 9.28 HTR1A HTR3A SLC6A4
3 Decreased viability GR00402-S-2 9.28 HTR1A HTR3A SLC6A4

MGI Mouse Phenotypes related to Panic Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.18 CCK CCKAR CCKBR COMT CRH HTR1A
2 cardiovascular system MP:0005385 9.97 CCKBR COMT HTR1A MAOA PTK7 SLC6A2
3 homeostasis/metabolism MP:0005376 9.93 CCK CCKAR CCKBR COMT CRH HTR1A
4 endocrine/exocrine gland MP:0005379 9.91 CCK CCKAR CCKBR COMT CRH HTR2A
5 nervous system MP:0003631 9.73 CCK CCKAR CCKBR COMT CRH HTR1A
6 renal/urinary system MP:0005367 9.17 CCK CCKAR CCKBR COMT CRH HTR3A
Sources

Drugs & Therapeutics for Panic Disorder

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Drugs for Panic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 195)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paroxetine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 61869-08-7 43815
2
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
3
Dopamine Approved Phase 4,Phase 3,Phase 2,Not Applicable 51-61-6, 62-31-7 681
4
Norepinephrine Approved Phase 4,Phase 3,Not Applicable 51-41-2 439260
5
Citalopram Approved Phase 4,Phase 1,Not Applicable 59729-33-8 2771
6
Sertraline Approved Phase 4,Phase 2,Phase 3,Phase 1 79617-96-2 68617
7
Vortioxetine Approved, Investigational Phase 4 508233-74-7 9966051
8
Clonazepam Approved, Illicit Phase 4,Phase 2,Phase 3 1622-61-3 2802
9
Alprazolam Approved, Illicit, Investigational Phase 4,Phase 2,Phase 1 28981-97-7 2118
10
Clozapine Approved Phase 4 5786-21-0 2818
11
Risperidone Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 106266-06-2 5073
12
Ziprasidone Approved Phase 4 146939-27-7 60854
13
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
14
Ethanol Approved Phase 4,Phase 2,Phase 3,Not Applicable 64-17-5 702
15
Suvorexant Approved, Investigational Phase 4 1030377-33-3
16
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
17
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
18
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
19 Cytochrome P-450 CYP2D6 Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
20 Serotonin Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
21 Antidepressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
24 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
25 Antidepressive Agents, Second-Generation Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
26 Serotonin Uptake Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
27 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
28 Quetiapine Fumarate Phase 4,Not Applicable 111974-72-2
29 GABA Agents Phase 4,Phase 2,Phase 3,Phase 1
30 Anticonvulsants Phase 4,Phase 2,Phase 3
31 Antimanic Agents Phase 4
32 Tranquilizing Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
33 Antipsychotic Agents Phase 4,Phase 3,Phase 2,Not Applicable
34 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
35 Duloxetine Hydrochloride Phase 4
36 Dopamine Agents Phase 4,Phase 3,Phase 2,Not Applicable
37 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4,Phase 3,Not Applicable
38 Analgesics Phase 4,Not Applicable
39 Peripheral Nervous System Agents Phase 4,Phase 1,Not Applicable,Early Phase 1
40 Parasympatholytics Phase 4,Phase 1,Not Applicable
41 Antiparkinson Agents Phase 4,Phase 1,Not Applicable
42 Cholinergic Antagonists Phase 4,Phase 1,Not Applicable
43 Cholinergic Agents Phase 4,Phase 1,Not Applicable,Early Phase 1
44 Muscarinic Antagonists Phase 4,Phase 1,Not Applicable
45 Autonomic Agents Phase 4,Phase 1,Not Applicable,Early Phase 1
46 Anti-Anxiety Agents Phase 4,Phase 2,Phase 1,Not Applicable
47 Serotonin Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
48 Serotonin 5-HT1 Receptor Agonists Phase 4
49 Serotonin 5-HT3 Receptor Antagonists Phase 4
50 GABA Modulators Phase 4,Phase 2,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 277)
# Name Status NCT ID Phase Drugs
1 Costs of Lost Productive Time Among Korean Workers With Panic Disorder and Effect of Treatment With Paroxetine Controlled Release Unknown status NCT00492414 Phase 4 Paroxetine CR
2 Quetiapine SR and Divalproex Sodium ER in the Treatment of Anxiety in Bipolar Disorder With Panic Disorder and/or GAD Unknown status NCT00579280 Phase 4 quetiapine SR;divalproex sodium ER;placebo
3 The Efficacy and Tolerability of Duloxetine for the Treatment of Panic Disorder Completed NCT00438971 Phase 4 Duloxetine
4 A Study of Quetiapine SR (Seroquel SR) to Treat SSRI-Resistant, Comorbid Panic Disorder Patients Completed NCT00619892 Phase 4 quetiapine XR;placebo
5 A Study Of Sertraline Compared With Paroxetine In The Treatment Of Panic Disorder Completed NCT00677352 Phase 4 sertraline;Paroxetine
6 Paroxetine vs Placebo Combined With Aerobic Exercise or Relaxation in Panic Disorder Completed NCT00540098 Phase 4 paroxetine + aerobic exercise;Paroxetine + relaxation;Placebo + aerobic exercise;Placebo + relaxation
7 Escitalopram Trial for Irritable Bowel Syndrome (IBS) Patients With Panic Disorder Completed NCT01551225 Phase 4 Escitalopram
8 Changes of Cerebral Glucose Metabolism After 12 Weeks of Paroxetine Treatment in Panic Disorder Completed NCT00767754 Phase 4 Paxil CR
9 Changes of Cerebral Glucose Metabolism and After 12 Weeks of Escitalpram Treatment in Panic Disorder Completed NCT00767871 Phase 4 Lexapro
10 A 10-Week, Open-Label, Flexible Dose Adaptive Study Evaluating the Efficacy of Vortioxetine in Subjects With Panic Disorder Completed NCT02395510 Phase 4 Vortioxetine
11 Long Term Treatment of Panic Disorder With Clonazepam or Paroxetine Completed NCT02852577 Phase 4 Clonazepam;Paroxetine
12 Efficacy of Aerobic Exercise Added to Alprazolam in Panic Disorder Treatment Completed NCT00803400 Phase 4 Alprazolam;Alprazolam + Aerobic exercise
13 Evaluation of Clonazepam and Paroxetine for Panic Disorder With Depression Completed NCT00031317 Phase 4 Paroxetine;Clozapine
14 Trial to Compare Time to Response in the Symptoms of Anxiety to Concomitant Treatment With Niravamâ„¢ and an SSRI or SNRI to Treatment With an SSRI or SNRI Alone in Subjects With Generalized Anxiety Disorder or Panic Disorder Completed NCT00266409 Phase 4 Niravam;SSRI/SNRI
15 A Study of Sertraline and Early Alprazolam XR Administration Versus Sertraline Only in Panic Disorder Patients Completed NCT00198094 Phase 4 Sertraline and Alprazolam XR
16 A Study of Risperidone Monotherapy in Bipolar Anxiety Completed NCT00167479 Phase 4 risperidone (Risperdal)
17 Ziprasidone in Bipolar Disorder With Comorbid Lifetime Panic or Generalized Anxiety Disorder(GAD) Completed NCT01172652 Phase 4 Ziprasidone;Placebo
18 Aripiprazole for the Treatment of Refractory Anxiety Completed NCT00438386 Phase 4 Aripiprazole
19 The Effects of Treatment With Sertraline for Noncardiac Chest Pain Completed NCT01114100 Phase 4 sertraline;placebo
20 A Collaborative Care Program to Improve Treatment of Depression and Anxiety Disorders in Cardiac Patients Completed NCT01201967 Phase 4
21 Primary Care Intervention Strategy for Anxiety Disorders Completed NCT00347269 Phase 4 Psychotropic medication optimization
22 A Double Blind, Randomized Placebo Controlled Study of the Efficacy, Safety and of Quetiapine Fumarate (Seroquel®) as Potentiation SSRI's, and SNRI's Treatment in Major Depression With Anxiety Completed NCT00229645 Phase 4 Quetiapine Fumarate (Seroquel®)
23 Paroxetine - Controlled Release in the Treatment of Irritable Bowel Syndrome (IBS) Completed NCT00610909 Phase 4 Paroxetine CR;Placebo
24 Trial of Seroquel SR for Alcohol Dependence and Comorbid Anxiety Completed NCT00352469 Phase 4 Seroquel XR
25 Non Cardiac Chest Pain and Benign Palpitations Completed NCT00623454 Phase 4
26 Cognitive Behavioral Therapy Versus Sertraline in the Treatment of Post-Traumatic Stress Disorder Completed NCT00391430 Phase 4 Sertraline
27 Treatments for Anxiety: Meditation and Escitalopram Recruiting NCT03522844 Phase 4 Escitalopram
28 The Role of Orexin in Human Panic Disorder Active, not recruiting NCT02593682 Phase 4 suvorexant;placebo
29 Ketamine Infusion for Adolescent Depression and Anxiety Active, not recruiting NCT02579928 Phase 4 Ketamine;Midazolam
30 A Study to Evaluate the Benefit of Octagam 5%® in Subjects With Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) Active, not recruiting NCT03348618 Phase 4
31 A 14 Week, Randomized, Placebo-Controlled Cross-Over Study of Methylphenidate Hydrochloride Controlled Release Capsules in Adult ADHD With and Without Anxiety Disorder Comorbidity Not yet recruiting NCT03785223 Phase 4 Methylphenidate Hydrochloride Controlled-Release Capsules;Placebo Capsule
32 Guanfacine Extended Release and Mindfulness Skills Therapy Not yet recruiting NCT03258476 Phase 4 Guanfacine Extended Release;Placebo
33 A Study to Evaluate the Use of Extended Release Alprazolam in the Treatment of Adolescents With Panic Disorder Terminated NCT00635531 Phase 4 alprazolam XR
34 A Study to Assess the Long-Term Use of Alprazolam Extended Release (XL) in the Treatment of Adolescents With Panic Disorder Terminated NCT00635076 Phase 4 alprazolam XR
35 A Study To Assess the Safety of Extended Release Alprazolam for the Treatment of Adolescents With Panic Disorder or Anxiety With Panic Attacks Terminated NCT00634790 Phase 4 alprazolam XR
36 Sertraline in Generalized Social Phobia With Co-Occurring Anxiety and Mood Disorders Terminated NCT00182533 Phase 4 Sertraline;Placebo
37 Mechanisms of Panic Disorders Treatment Unknown status NCT01323556 Phase 2, Phase 3
38 Study Comparing Venlafaxine vs. Paroxetine in Panic Disorder Completed NCT00195598 Phase 3 VENLAFAXINE;Paroxetine
39 Psychodynamic Therapy for Treating Panic Disorder Completed NCT00128388 Phase 2, Phase 3
40 Therapies for Treatment-Resistant Panic Disorder Symptoms Completed NCT00118417 Phase 2, Phase 3 Clonazepam;Sertraline
41 Internet-Versus Group-Administered Cognitive Behavior Therapy for Panic Disorder Completed NCT00845260 Phase 3
42 Treatment of Panic Disorder: Long Term Strategies Completed NCT00000368 Phase 3 Paroxetine or other medication - algorithm used
43 Comparison of Psychotherapy Programs to Treat Panic Disorder Completed NCT00353470 Phase 3
44 Levetiracetam Treatment of Panic Disorder and Lactate-Induced Panic Attacks Completed NCT00279617 Phase 3 levetiracetam
45 Study Evaluating Venlafaxine ER in Patients With Panic Disorder Completed NCT00044772 Phase 3 Venlafaxine ER
46 Study Evaluating Venlafaxine ER in Adults With Panic Disorder Completed NCT00038896 Phase 3 Venlafaxine ER
47 Treatment of Social Phobia and Panic Disorder in Adults Completed NCT00619138 Phase 3
48 Improving Quality of Primary Care for Patients With Anxiety and/or Panic Disorders Completed NCT00102427 Phase 2, Phase 3
49 Telephone-Based Care Management Program for Individuals With Anxiety Disorders Completed NCT00158327 Phase 3
50 Online Treatments for Mood and Anxiety Disorders in Primary Care Completed NCT01482806 Phase 2, Phase 3

Search NIH Clinical Center for Panic Disorder

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: panic disorder

Sources

Genetic Tests for Panic Disorder

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Anatomical Context for Panic Disorder

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MalaCards organs/tissues related to Panic Disorder:

41
Heart, Brain, Testes, Cortex, Amygdala, Pituitary, Thyroid
Sources

Publications for Panic Disorder

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Articles related to Panic Disorder:

(show top 50) (show all 1654)
# Title Authors Year
1
The Experience Sampling Method-Evaluation of treatment effect of escitalopram in IBS with comorbid panic disorder. ( 30460734 )
2019
2
Cue and context conditioning to respiratory threat: Effects of suffocation fear and implications for the etiology of panic disorder. ( 29330006 )
2018
3
Dismantling cognitive-behaviour therapy for panic disorder: a systematic review and component network meta-analysis. ( 29368665 )
2018
4
Reappraising Preclinical Models of Separation Anxiety Disorder, Panic Disorder, and CO<sub>2</sub> Sensitivity: Implications for Methodology and Translation into New Treatments. ( 29696603 )
2018
5
Respiratory subtype of panic disorder: Can serum phosphate levels be a possible outcome to group cognitive-behavior therapy? ( 29680728 )
2018
6
Auricular Chromotherapy in the Treatment of Psychologic Trauma, Phobias, and Panic Disorder. ( 29937969 )
2018
7
The effect of panic disorder versus anxiety sensitivity on event-related potentials during anticipation of threat. ( 29291580 )
2018
8
Social Support and Symptom Severity Among Patients With Obsessive-Compulsive Disorder or Panic Disorder With Agoraphobia: A Systematic Review. ( 29899808 )
2018
9
Is panic disorder a disorder of physical fitness? A heuristic proposal. ( 29623195 )
2018
10
The differences between patients with panic disorder and healthy controls in psychophysiological stress profile. ( 29445280 )
2018
11
Predictors of Broad Dimensions of Psychopathology among Patients with Panic Disorder after Cognitive-Behavioral Therapy. ( 29721499 )
2018
12
Effect of high-frequency repetitive transcranial magnetic stimulation (rTMS) in patients with comorbid panic disorder and major depression. ( 29737182 )
2018
13
Koro in panic disorder: Beyond a culture bound phenomena. ( 29447990 )
2018
14
Differential electrophysiological correlates of panic disorder in non-pulsatile tinnitus. ( 29773153 )
2018
15
A Brief Interview to Detect Panic Attacks and Panic Disorder in Emergency Department Patients with Cardiopulmonary Complaints. ( 29320381 )
2018
16
Is 472G/A catechol-O-methyl-transferase gene polymorphism related to panic disorder?: Erratum. ( 29957743 )
2018
17
The relationship between impulsivity and panic disorder-agoraphobia: The role of affective temperament. ( 29649673 )
2018
18
Prevalence and treatment of panic disorder in bipolar disorder: systematic review and meta-analysis. ( 29636354 )
2018
19
Stress hormone response to the DEX-CRH test and its relation to psychotherapy outcome in panic disorder patients with and without agoraphobia. ( 29391399 )
2018
20
Stress-induced pro- and anti-inflammatory cytokine concentrations in panic disorder patients. ( 29754003 )
2018
21
Antidepressants versus placebo for panic disorder in adults. ( 29620793 )
2018
22
Predictors of etiological beliefs about panic disorder and impact of beliefs on treatment outcomes. ( 29635142 )
2018
23
Can Religious Coping and Depressive Symptoms Predict Clinical Outcome and Quality of Life in Panic Disorder? A Brazilian Longitudinal Study. ( 29905662 )
2018
24
Cardiorespiratory concerns shape brain responses during automatic panic-related scene processing in patients with panic disorder. ( 29252163 )
2018
25
Changes in perceived centrality of anxious events following cognitive behavioral therapy for social anxiety disorder and panic disorder. ( 29425950 )
2018
26
Whole-exome sequencing and gene-based rare variant association tests suggest that PLA2G4E might be a risk gene for panic disorder. ( 29391400 )
2018
27
Cytokine alterations in panic disorder: A systematic review. ( 29241050 )
2018
28
An open-label, flexible dose adaptive study evaluating the efficacy of vortioxetine in subjects with panic disorder. ( 29760763 )
2018
29
The neural markers of MRI to differentiate depression and panic disorder. ( 29705713 )
2018
30
Running for extinction? Aerobic exercise as an augmentation of exposure therapy in panic disorder with agoraphobia. ( 29539585 )
2018
31
Varenicline-Induced Panic Disorder in a Previously Healthy Patient. ( 29363353 )
2018
32
Internet-based treatment for panic disorder: A three-arm randomized controlled trial comparing guided (via real-time video sessions) with unguided self-help treatment and a waitlist control. PAXPD study results. ( 29625834 )
2018
33
Risks and benefits of medications for panic disorder: a comparison of SSRIs and benzodiazepines. ( 29357714 )
2018
34
Pretreatment Cardiac Vagal Tone Predicts Dropout from and Residual Symptoms after Exposure Therapy in Patients with Panic Disorder and Agoraphobia. ( 29533952 )
2018
35
Association between apolipoprotein E genotypes and panic disorder in Turkish population. ( 29888635 )
2018
36
Predictors of remission from panic disorder, agoraphobia and specific phobia in outpatients receiving exposure therapy: The importance of positive mental health. ( 29981937 )
2018
37
Integration of EMDR and CBT Techniques in Treatment of Panic Disorder with Agoraphobia - A Case Report. ( 30095822 )
2018
38
Suicidal ideation in primary care patients suffering from panic disorder with or without agoraphobia. ( 30249220 )
2018
39
Effects of Cognitive Behavioral Therapy on Neural Processing of Agoraphobia-Specific Stimuli in Panic Disorder and Agoraphobia. ( 30269148 )
2018
40
The impact of depressive comorbidity on neural plasticity following cognitive-behavioral therapy in panic disorder with agoraphobia. ( 30428445 )
2018
41
Commentary on RANZCP clinical practice guidelines for the treatment of panic disorder, social anxiety disorder and generalised anxiety disorder. ( 30511582 )
2018
42
Will the RANZCP clinical practice guidelines for the treatment of anxiety disorders assist in making adequate treatment decisions for panic disorder? ( 30518224 )
2018
43
Duration of untreated illness in a cross-diagnostic sample of obsessive-compulsive disorder, panic disorder, and social anxiety disorder. ( 30419984 )
2018
44
Clinical and Neurofunctional Substrates of Cognitive Behavioral Therapy on Secondary Social Anxiety Disorder in Primary Panic Disorder: A Longitudinal fMRI Study. ( 30368504 )
2018
45
The BDNF Val66Met gene polymorphism is associated with increased alexithymic and anticipatory anxiety in patients with panic disorder. ( 30269521 )
2018
46
Impaired discriminative fear conditioning during later training trials differentiates generalized anxiety disorder, but not panic disorder, from healthy control participants. ( 30005181 )
2018
47
Predictors of benzodiazepine use in a transdiagnostic sample of panic disorder, social anxiety disorder, and obsessive-compulsive disorder patients. ( 29475102 )
2018
48
Twelve-Month Outcomes Following Successful Panic-Focused Psychodynamic Psychotherapy, Cognitive-Behavioral Therapy, or Applied Relaxation Training for Panic Disorder. ( 30256548 )
2018
49
Cognitive-behavioral therapy effects on alerting network activity and effective connectivity in panic disorder. ( 30288559 )
2018
50
A Novel Bio-Psychosocial-Behavioral Treatment Model of Panic Disorder. ( 30301303 )
2018
Sources

Variations for Panic Disorder

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Expression for Panic Disorder

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Search GEO for disease gene expression data for Panic Disorder.
Sources

Pathways for Panic Disorder

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Pathways related to Panic Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.85 HTR1A HTR2A HTR3A MAOA SLC6A4 TPH2
2
Serotonergic synapse 37
11.49 HTR1A HTR2A HTR3A MAOA SLC6A4 TPH2
3
Clomipramine Pathway, Pharmacokinetics 61
Show member pathways
 11.4 COMT SLC6A2 SLC6A4
4
Monoamine Transport 1
Show member pathways
 11.19 MAOA SLC6A2 SLC6A4 TPH2
5
Neurotransmitter Clearance In The Synaptic Cleft 66
Show member pathways
 10.91 COMT MAOA SLC6A4
6
Biogenic Amine Synthesis 1
Show member pathways
 10.82 COMT MAOA
7
noradrenaline and adrenaline degradation 1
Show member pathways
 10.63 COMT MAOA
8
Dopamine metabolism 1
10.58 COMT MAOA
9
Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics 61
10.55 HTR1A HTR2A HTR3A MAOA SLC6A4 TPH2
10
Cell-type Dependent Selectivity of CCK2R Signaling 1
10.52 CCK CCKBR
Sources

GO Terms for Panic Disorder

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Cellular components related to Panic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.7 CCKAR HTR1A HTR2A HTR3A PTK7 SLC6A2
2 axon GO:0030424 9.56 CCK COMT HTR2A HTR3A
3 integral component of presynaptic membrane GO:0099056 9.13 HTR2A HTR3A SLC6A4
4 integral component of postsynaptic membrane GO:0099055 8.8 HTR2A HTR3A SLC6A4

Biological processes related to Panic Disorder according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.98 CCK CCKBR CRH HTR1A HTR2A
2 chemical synaptic transmission GO:0007268 9.77 CRH HTR1A HTR2A HTR3A SLC6A2
3 memory GO:0007613 9.74 CCK HTR2A SLC6A4
4 response to estrogen GO:0043627 9.67 COMT CRH TPH2
5 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.63 CCKAR CCKBR HTR2A
6 response to drug GO:0042493 9.63 COMT CRH HTR2A SLC6A2 SLC6A4 TSPO
7 adrenal gland development GO:0030325 9.6 CRH TSPO
8 vasoconstriction GO:0042310 9.59 HTR1A SLC6A4
9 catecholamine metabolic process GO:0006584 9.56 COMT MAOA
10 neurotransmitter catabolic process GO:0042135 9.55 COMT MAOA
11 behavior GO:0007610 9.54 HTR1A HTR2A
12 monoamine transport GO:0015844 9.52 SLC6A2 SLC6A4
13 positive regulation of mitochondrial depolarization GO:0051901 9.51 CCK TSPO
14 dopamine catabolic process GO:0042420 9.48 COMT MAOA
15 positive regulation of behavioral fear response GO:2000987 9.43 CCK CRH
16 regulation of hormone secretion GO:0046883 9.4 CCKAR HTR1A
17 cholecystokinin signaling pathway GO:0038188 9.32 CCKAR CCKBR
18 regulation of serotonin secretion GO:0014062 9.26 CRH HTR1A
19 serotonin receptor signaling pathway GO:0007210 9.13 HTR1A HTR2A HTR3A
20 response to pain GO:0048265 8.92 COMT CRH SLC6A2 TSPO
21 signal transduction GO:0007165 10.18 CCK CCKAR CCKBR CRH HTR1A HTR2A

Molecular functions related to Panic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neurotransmitter:sodium symporter activity GO:0005328 9.26 SLC6A2 SLC6A4
2 monoamine transmembrane transporter activity GO:0008504 9.16 SLC6A2 SLC6A4
3 cholecystokinin receptor activity GO:0004951 8.96 CCKAR CCKBR
4 serotonin binding GO:0051378 8.92 HTR1A HTR2A HTR3A SLC6A4
Sources

Sources for Panic Disorder

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
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46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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