PAND1
MCID: PNC122
MIFTS: 19

Panic Disorder 1 (PAND1)

Categories: Mental diseases, Neuronal diseases, Respiratory diseases

Aliases & Classifications for Panic Disorder 1

MalaCards integrated aliases for Panic Disorder 1:

Name: Panic Disorder 1 57 29 39 70
Panic Disorder Syndrome 1 57 13
Panic Disorder Susceptibility Locus, Chromosome 13q-Related 57
Pand1 57

Characteristics:

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
? autosomal dominant form


HPO:

31
panic disorder 1:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM® 57 167870
MedGen 41 C1868649
SNOMED-CT via HPO 68 263681008 48694002
UMLS 70 C1868649

Summaries for Panic Disorder 1

OMIM® : 57 The DSM-IV (American Psychiatric Association, 1994) defines panic disorder as the spontaneous, unexpected occurrence of panic attacks followed by persistent concern, worry, and anxiety about having additional panic attacks. Panic attacks are defined as a discrete period of intense fear or discomfort in which at least 4 of 13 symptom criteria are met that develop abruptly and reach a peak within 10 minutes. Some of these criteria include cardiac palpitations, sweating, feelings of choking, fear of losing control, and fear of dying. Panic disorder is divided into panic disorder with or without accompanying agoraphobia. However, agoraphobia can also occur without panic disorder, and panic attacks can occur in the absence of panic disorder. Comorbidity with depressive and addictive disorders is frequent. Barlow et al. (1994) and Smoller and Tsuang (1998) noted that because the diagnostic criteria remain purely clinical, the nosology of anxiety disorders, such as panic disorder, is controversial and evolving. Therefore, it is difficult to do genetic studies because of the difficulty in delineating overlapping phenotypes within the broader context of anxiety disorders. For example, there may be overlap of panic with specific phobias, variable expressivity of panic and anxiety or depression, or phenocopies within a family. The terms 'anxiety neurosis' and 'phobic neurosis' were used in the past (before the DSM-III in 1980) to encompass all of these disorders. Smoller and Tsuang (1998) suggested that dimensional personality traits, such as shyness, behavioral inhibition, and neuroticism (see 607834), could be used to define an anxiety phenotype. Schumacher et al. (2011) provided a review of the genetics of panic disorder. They noted that there is high (80%) comorbidity with other psychiatric disorders, including agoraphobia, mood disorders, substance abuse, and other anxiety disorders. Associated personality traits include anxiety sensitivity, behavioral inhibition, neuroticism, and harm avoidance. Women are more susceptible to development of the disorder, which has an average age of onset at 23.6 years. (167870) (Updated 05-Apr-2021)

MalaCards based summary : Panic Disorder 1, also known as panic disorder syndrome 1, is related to panic disorder and anxiety. An important gene associated with Panic Disorder 1 is COMT (Catechol-O-Methyltransferase). Related phenotype is anxiety.

Related Diseases for Panic Disorder 1

Diseases in the Panic Disorder family:

Panic Disorder 1 Panic Disorder 2
Panic Disorder 3

Diseases related to Panic Disorder 1 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 panic disorder 31.1 PAND1 COMT
2 anxiety 11.0

Symptoms & Phenotypes for Panic Disorder 1

Human phenotypes related to Panic Disorder 1:

31
# Description HPO Frequency HPO Source Accession
1 anxiety 31 HP:0000739

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
Neuro:
panic disorder (anxiety neurosis)

Clinical features from OMIM®:

167870 (Updated 05-Apr-2021)

Drugs & Therapeutics for Panic Disorder 1

Search Clinical Trials , NIH Clinical Center for Panic Disorder 1

Genetic Tests for Panic Disorder 1

Genetic tests related to Panic Disorder 1:

# Genetic test Affiliating Genes
1 Panic Disorder 1 29 COMT

Anatomical Context for Panic Disorder 1

Publications for Panic Disorder 1

Articles related to Panic Disorder 1:

(show all 39)
# Title Authors PMID Year
1
The genetics of panic disorder. 57
21493958 2011
2
A key role for orexin in panic anxiety. 57
20037593 2010
3
Familial clustering of major depression and anxiety disorders in Australian and Dutch twins and siblings. 57
16354503 2005
4
Failure to detect DUP25 in lymphoblastoid cells derived from patients with panic disorder and control individuals representing European and American populations. 57
15054397 2004
5
No evidence for DUP25 in patients with panic disorder using a quantitative real-time PCR approach. 57
14513359 2003
6
Bayesian analysis of a previously published genome screen for panic disorder reveals new and compelling evidence for linkage to chromosome 7. 57
12898582 2003
7
Further genetic evidence for a panic disorder syndrome mapping to chromosome 13q. 57
12604791 2003
8
Failure to find DUP25 in patients with anxiety disorders, in control individuals, or in previously reported positive control cell lines. 57
12548501 2003
9
Catechol O-methyltransferase genetic polymorphism in panic disorder. 57
12359690 2002
10
Evidence for a susceptibility locus for panic disorder near the catechol-O-methyltransferase gene on chromosome 22. 57
11950461 2002
11
A polymorphic genomic duplication on human chromosome 15 is a susceptibility factor for panic and phobic disorders. 57
11509185 2001
12
Genomewide survey of panic disorder. 57
11424978 2001
13
Potential panic disorder syndrome: clinical and genetic linkage evidence. 57
10686548 2000
14
Panic and phobic anxiety: defining phenotypes for genetic studies. 57
9734536 1998
15
No association between anxiety disorders and catechol-O-methyltransferase polymorphism. 57
9754693 1998
16
Results of a genome-wide genetic screen for panic disorder. 57
9613853 1998
17
Familial aggregation and phenomenology of 'early'-onset (at or before age 20 years) panic disorder. 57
9075468 1997
18
Panic attacks: a twin study. 57
9061805 1997
19
A twin study of DSM-III-R anxiety disorders. 57
8213211 1993
20
A family study of panic disorder. 57
3569877 1987
21
Relationship between panic disorder and agoraphobia. A family study. 57
3954542 1986
22
Genetic factors in anxiety disorders. 57
6625857 1983
23
A genetic study of panic disorder pedigrees. 57
7424907 1980
24
The familial prevalence of anxiety neurosis. 57
686969 1978
25
The high familial prevalence of neurocirculatory asthenia (anxiety neurosis, effort syndrome). 57
14902758 1951
26
A comprehensive model of predictors of suicide attempt in individuals with panic disorder: Results from a national 3-year prospective study. 61
33129137 2020
27
Panic disorder and agoraphobia: A direct comparison of their multivariate comorbidity patterns. 61
26480214 2016
28
Screening for anxiety disorders in patients with coronary artery disease. 61
23497087 2013
29
Opposing breathing therapies for panic disorder: a randomized controlled trial of lowering vs raising end-tidal P(CO₂). 61
22901344 2012
30
CBT, SSRI or both are similarly effective for panic disorder 1-year post-treatment. 61
21036987 2010
31
Cognitive style, alprazolam plasma levels, and treatment response in panic disorder. 61
17960759 2008
32
What is the threshold for symptomatic response and remission for major depressive disorder, panic disorder, social anxiety disorder, and generalized anxiety disorder? 61
17017830 2006
33
Outcomes of late-life anxiety disorders during 32 weeks of citalopram treatment. 61
16649835 2006
34
A 28-year-old woman with panic disorder, 1 year later. 61
12132981 2002
35
Panic disorder and social phobia: effects of comorbidity on familial transmission. 61
9160619 1996
36
Norplant-associated major depression and panic disorder. 61
7989280 1994
37
[Clinical and epidemiologic study of "generalized anxiety" in general practice]. 61
8050376 1994
38
Lessons to be learned from long-term treatment of affective disorders: potential utility in panic disorder. 61
1995597 1991
39
Imipramine in panic disorder. 1. Clinical response and pharmacological changes. 61
22282120 1991

Variations for Panic Disorder 1

Expression for Panic Disorder 1

Search GEO for disease gene expression data for Panic Disorder 1.

Pathways for Panic Disorder 1

GO Terms for Panic Disorder 1

Sources for Panic Disorder 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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