MCID: PNC122
MIFTS: 14

Panic Disorder 1

Categories: Mental diseases

Aliases & Classifications for Panic Disorder 1

MalaCards integrated aliases for Panic Disorder 1:

Name: Panic Disorder 1 57 29 40 73
Panic Disorder Syndrome 1 57 13
Panic Disorder Susceptibility Locus, Chromosome 13q-Related 57
Pand1 57

Characteristics:

OMIM:

57
Inheritance:
? autosomal dominant form


Classifications:



External Ids:

OMIM 57 167870
MedGen 42 C1868649
SNOMED-CT via HPO 69 48694002
UMLS 73 C1868649

Summaries for Panic Disorder 1

OMIM : 57 The DSM-IV (American Psychiatric Association, 1994) defines panic disorder as the spontaneous, unexpected occurrence of panic attacks followed by persistent concern, worry, and anxiety about having additional panic attacks. Panic attacks are defined as a discrete period of intense fear or discomfort in which at least 4 of 13 symptom criteria are met that develop abruptly and reach a peak within 10 minutes. Some of these criteria include cardiac palpitations, sweating, feelings of choking, fear of losing control, and fear of dying. Panic disorder is divided into panic disorder with or without accompanying agoraphobia. However, agoraphobia can also occur without panic disorder, and panic attacks can occur in the absence of panic disorder. Comorbidity with depressive and addictive disorders is frequent. Barlow et al. (1994) and Smoller and Tsuang (1998) noted that because the diagnostic criteria remain purely clinical, the nosology of anxiety disorders, such as panic disorder, is controversial and evolving. Therefore, it is difficult to do genetic studies because of the difficulty in delineating overlapping phenotypes within the broader context of anxiety disorders. For example, there may be overlap of panic with specific phobias, variable expressivity of panic and anxiety or depression, or phenocopies within a family. The terms 'anxiety neurosis' and 'phobic neurosis' were used in the past (before the DSM-III in 1980) to encompass all of these disorders. Smoller and Tsuang (1998) suggested that dimensional personality traits, such as shyness, behavioral inhibition, and neuroticism (see 607834), could be used to define an anxiety phenotype. Schumacher et al. (2011) provided a review of the genetics of panic disorder. They noted that there is high (80%) comorbidity with other psychiatric disorders, including agoraphobia, mood disorders, substance abuse, and other anxiety disorders. Associated personality traits include anxiety sensitivity, behavioral inhibition, neuroticism, and harm avoidance. Women are more susceptible to development of the disorder, which has an average age of onset at 23.6 years. (167870)

MalaCards based summary : Panic Disorder 1, also known as panic disorder syndrome 1, is related to panic disorder. An important gene associated with Panic Disorder 1 is COMT (Catechol-O-Methyltransferase). Related phenotype is anxiety.

Related Diseases for Panic Disorder 1

Diseases in the Panic Disorder family:

Panic Disorder 1 Panic Disorder 2
Panic Disorder 3

Diseases related to Panic Disorder 1 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 panic disorder 30.6 COMT PAND1

Symptoms & Phenotypes for Panic Disorder 1

Symptoms via clinical synopsis from OMIM:

57
Neuro:
panic disorder (anxiety neurosis)


Clinical features from OMIM:

167870

Human phenotypes related to Panic Disorder 1:

32
# Description HPO Frequency HPO Source Accession
1 anxiety 32 HP:0000739

Drugs & Therapeutics for Panic Disorder 1

Search Clinical Trials , NIH Clinical Center for Panic Disorder 1

Genetic Tests for Panic Disorder 1

Genetic tests related to Panic Disorder 1:

# Genetic test Affiliating Genes
1 Panic Disorder 1 29 COMT

Anatomical Context for Panic Disorder 1

Publications for Panic Disorder 1

Variations for Panic Disorder 1

Expression for Panic Disorder 1

Search GEO for disease gene expression data for Panic Disorder 1.

Pathways for Panic Disorder 1

GO Terms for Panic Disorder 1

Sources for Panic Disorder 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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