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MCID: PNN001
MIFTS: 49

Panniculitis

Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Panniculitis

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MalaCards integrated aliases for Panniculitis:

Name: Panniculitis 12 77 30 56 45 15 17 74

Classifications:

MalaCards categories:
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:1526
ICD9CM 36 729.3 729.30
MeSH 45 D015434
NCIt 51 C112112
SNOMED-CT 69 22125009
ICD10 34 M79.3
UMLS 74 C0030326
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Summaries for Panniculitis

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MalaCards based summary : Panniculitis is related to peripheral t-cell lymphoma and cutaneous t cell lymphoma, and has symptoms including pruritus, myalgia and exanthema. An important gene associated with Panniculitis is OTULIN (OTU Deubiquitinase With Linear Linkage Specificity), and among its related pathways/superpathways are Apoptosis and survival Caspase cascade and NF-kappaB Signaling. The drugs Prednisone and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and neutrophil, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 77 Panniculitis is a group of diseases whose hallmark is inflammation of subcutaneous adipose tissue (the... more...

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Related Diseases for Panniculitis

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Diseases related to Panniculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 360)
# Related Disease Score Top Affiliating Genes
1 peripheral t-cell lymphoma 29.9 GZMB NCAM1 TIA1
2 cutaneous t cell lymphoma 29.6 GZMB IFNG TIA1
3 hemophagocytic lymphohistiocytosis 29.6 FAS GZMB IFNG
4 bronchiolitis obliterans 29.2 GZMB IFNG
5 alopecia areata 29.1 GZMB IFNG
6 graft-versus-host disease 29.0 FAS GZMB IFNG
7 nodular nonsuppurative panniculitis 12.8
8 t-cell lymphoma, subcutaneous panniculitis-like 12.7
9 autoinflammation, panniculitis, and dermatosis syndrome 12.5
10 lupus erythematosus panniculitis 12.4
11 cytophagic histiocytic panniculitis 12.3
12 infantile onset panniculitis with uveitis and systemic granulomatosis 12.2
13 panniculitis-induced localized lipodystrophy 12.0
14 localized lipodystrophy 12.0
15 lipodermatosclerosis 11.9
16 proteasome-associated autoinflammatory syndrome 1 11.9
17 alpha-1-antitrypsin deficiency 11.6
18 igg4-related mesenteritis 11.6
19 peritonitis 11.5
20 acquired generalized lipodystrophy 11.4
21 proteasome-associated autoinflammatory syndrome 3 11.2
22 autoimmune lymphoproliferative syndrome 11.0
23 erythema nodosum, idiopathic 11.0
24 lymphoma 10.8
25 lupus erythematosus 10.6
26 pancreatitis 10.5
27 dermatomyositis 10.4
28 lichen sclerosus et atrophicus 10.3 GZMB TIA1
29 lymphomatoid granulomatosis 10.3 GZMB TIA1
30 viral esophagitis 10.3 GZMB TIA1
31 systemic lupus erythematosus 10.3
32 primary cutaneous anaplastic large cell lymphoma 10.3 GZMB TIA1
33 vasculitis 10.3
34 composite lymphoma 10.3 GZMB TIA1
35 hepatosplenic t-cell lymphoma 10.3 GZMB TIA1
36 choriocarcinoma of the testis 10.3 GZMB TIA1
37 fasciitis 10.3
38 lethal midline granuloma 10.3 NCAM1 TIA1
39 giardiasis 10.3 GZMB TIA1
40 arthritis 10.3
41 infiltrating lipoma 10.3 GZMB TIA1
42 necrotizing sialometaplasia 10.3 GZMB TIA1
43 dermatitis 10.3
44 rhinoscleroma 10.3 NCAM1 SERPINA1
45 t-cell large granular lymphocyte leukemia 10.2 GZMB NCAM1
46 cystadenofibroma 10.2 NCAM1 SERPINA1
47 angioimmunoblastic t-cell lymphoma 10.2 GZMB TIA1
48 lymphatic system cancer 10.2 NCAM1 TIA1
49 lung lymphoma 10.2 GZMB NCAM1
50 multiple sclerosis 10.2

Graphical network of the top 20 diseases related to Panniculitis:



Diseases related to Panniculitis
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Symptoms & Phenotypes for Panniculitis

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UMLS symptoms related to Panniculitis:


pruritus, myalgia, exanthema, decreased adipose tissue, other musculoskeletal symptoms referable to limbs, pain in limb, integumentary system signs and symptoms

GenomeRNAi Phenotypes related to Panniculitis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.64 FAS GZMB NAV3 PSMB8 TIA1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.64 FAS GZMB NAV3 PSMB8 TIA1 BTK

MGI Mouse Phenotypes related to Panniculitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.17 BTK FAS HAVCR2 IFNG OTULIN PSMB8
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Drugs & Therapeutics for Panniculitis

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Drugs for Panniculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 89)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
2
Ifosfamide Approved Phase 4 3778-73-2 3690
3
Etoposide Approved Phase 4 33419-42-0 36462
4
Vincristine Approved, Investigational Phase 4 2068-78-2, 57-22-7 5978
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
6
Epirubicin Approved Phase 4 56420-45-2 41867
7
Cyclophosphamide Approved, Investigational Phase 4,Not Applicable 50-18-0, 6055-19-2 2907
8
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
9
Cisplatin Approved Phase 4 15663-27-1 2767 441203 84093
10
Gemcitabine Approved Phase 4,Phase 1,Phase 2 95058-81-4 60750
11
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
12
Testosterone enanthate Approved Phase 4 315-37-7 9416
13
Methyltestosterone Approved Phase 4 58-18-4 6010
14
Testosterone Approved, Experimental, Investigational Phase 4 58-22-0, 481-30-1 10204 6013
15
leucovorin Approved Phase 4,Phase 1,Phase 2 58-05-9 143 6006
16
Mechlorethamine Approved, Investigational Phase 4 51-75-2 4033
17
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
18
Doxorubicin Approved, Investigational Phase 4 23214-92-8 31703
19
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 59-30-3 6037
20
Pirarubicin Investigational Phase 4 72496-41-4
21
Doxil Approved June 1999 Phase 4 31703
22 Hormones Phase 4,Phase 2,Not Applicable
23 Anti-Bacterial Agents Phase 4,Phase 1
24 Antimitotic Agents Phase 4
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
26 Alkylating Agents Phase 4,Not Applicable
27 Topoisomerase Inhibitors Phase 4
28 Antineoplastic Agents, Hormonal Phase 4
29 Immunosuppressive Agents Phase 4,Phase 1,Phase 2,Not Applicable
30 Antirheumatic Agents Phase 4,Phase 1,Not Applicable
31 Anti-Inflammatory Agents Phase 4
32 glucocorticoids Phase 4
33 Etoposide phosphate Phase 4
34 Immunologic Factors Phase 4,Phase 1,Phase 2,Not Applicable
35 Antibiotics, Antitubercular Phase 4,Phase 1
36 BB 1101 Phase 4
37 Antineoplastic Agents, Phytogenic Phase 4
38 Hormone Antagonists Phase 4
39
Isophosphamide mustard Phase 4 0
40 Antineoplastic Agents, Alkylating Phase 4,Not Applicable
41 Testosterone 17 beta-cypionate Phase 4
42 Androgens Phase 4
43 Anabolic Agents Phase 4
44 Insulin, Globin Zinc Phase 4
45 insulin Phase 4
46 Vitamin B Complex Phase 4,Phase 1,Phase 2
47 Folate Phase 4,Phase 1,Phase 2
48 Vitamin B9 Phase 4,Phase 1,Phase 2
49 Antimetabolites, Antineoplastic Phase 4,Phase 1,Phase 2
50 Antimetabolites Phase 4,Phase 1,Phase 2

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 CEOP/IVE/GDP Compared With CEOP as the First-line Therapy for Newly Diagnosed Adult Patients With PTCL Unknown status NCT02533700 Phase 4 CEOP/IVE/GDP chemotherapy regimen;CEOP chemotherapy regimen for 6 cycles
2 Testosterone Replacement in Metabolic Syndrome and Inflammation Completed NCT01123278 Phase 4 Testosterone;Placebo
3 CTOP/ITE/MTX Compared With CHOP as the First-line Therapy for Newly Diagnosed Young Patients With T Cell Lymphoma Active, not recruiting NCT01746992 Phase 4 Cyclophosphamide 750mg/m2;Vincristine 1.4mg/m2;Doxorubicin 50mg/m2;prednisone 60mg/m2;ifosfamide 2000mg/m2;pirarubicin 50mg/m2;pirarubicin 25mg/m2;Etoposide phosphate 100mg/m2;methotrexate 1500mg/m2
4 Effectiveness and Safety of Autologous ADRC for Treatment of Degenerative Damage of Knee Articular Cartilage Completed NCT02219113 Phase 1, Phase 2
5 Study of Pralatrexate & Gemcitabine With B12 & Folic Acid to Treat Relapsed/Refractory Lymphoproliferative Malignancies Completed NCT00481871 Phase 1, Phase 2 Pralatrexate Injection;Gemcitabine Hydrochloride
6 A Phase II Study to Evaluate Safety and Efficacy of ALX-0061 in Subjects With Systemic Lupus Erythematosus Completed NCT02437890 Phase 2
7 Effectiveness and Safety of Autologous ADRC for Treatment of Anterior Cruciate Ligament Partial Rupture Enrolling by invitation NCT02469792 Phase 1, Phase 2
8 Autologous Stromal Vascular Fraction of Cells for Treatment of Knee Articular Cartilage Dystrophy Enrolling by invitation NCT02827851 Phase 2
9 Vitamin D Status, Disease Specific and Quality of Life Outcomes in Patients With Cutaneous Lupus Terminated NCT01498406 Phase 2
10 Phase 1 Trial of Siplizumab and Dose-Adjusted EPOCH-Rituximab in T- and NK-Cell Lymphomas Active, not recruiting NCT01445535 Phase 1 EPOCH
11 Everolimus and Bortezomib in Treating Patients With Relapsed or Refractory Lymphoma Terminated NCT00671112 Phase 1 Bortezomib;Everolimus
12 Inflammation and Oxidative Stress of Adipose Tissue in Sleep Apnea Syndrome Unknown status NCT01196845 Not Applicable
13 Mesenteric Panniculitis : Review of Consecutive Abdominal MDCT Examinations With a Matched-pair Analysis Completed NCT03316001
14 Characterization of Transient Alterations of Cutaneous Sensory Nerve Function by Cryolipolysis Completed NCT01673113 Not Applicable
15 Diet Induced Weight Loss to Reduce Inflammation in Obese Women Completed NCT01699906 Not Applicable
16 GENETIC SUSCEPTIBILITY FACTOR AS A PREDICTOR OF TYPE 2 DIABETES REMISSION AND WEIGHT LOSS AFTER BARIATRIC SURGERY Completed NCT02405949
17 Cyclophosphamide in the Treatment of Associated Acquired Lipodystrophy Syndrome With Type 1 Diabetes Recruiting NCT03936829 Not Applicable Cyclophosphamide
18 T-Cell Project: Prospective Collection of Data in Patients With Peripheral T-Cell Lymphoma Recruiting NCT01142674
19 Leipzig Adipose Tissue Childhood Cohort Recruiting NCT02208141
20 Cholecalciferol in Improving Survival in Patients With Newly Diagnosed Cancer With Vitamin D Insufficiency Recruiting NCT01787409 Not Applicable
21 Study of the Efficacy of 532nm Laser and 1064 nm Laser in the Treatment of Cutaneous Lupus Erythematous Versus Topical Corticosteroids Alone Recruiting NCT03639857 Not Applicable Topical corticosteroid
22 Salvia Hispanica Seed in Reducing Risk of Disease Recurrence in Patients With Non-Hodgkin Lymphoma Active, not recruiting NCT02652715 Not Applicable
23 Prospective Study of Functional and Quality of Life Outcomes in Panniculectomy Patients Terminated NCT01464658 Not Applicable

Search NIH Clinical Center for Panniculitis

Cochrane evidence based reviews: panniculitis

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Genetic Tests for Panniculitis

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Genetic tests related to Panniculitis:

# Genetic test Affiliating Genes
1 Panniculitis 30
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Anatomical Context for Panniculitis

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MalaCards organs/tissues related to Panniculitis:

42
T Cells, Skin, Neutrophil, B Cells, Bone, Pancreas, Myeloid
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Publications for Panniculitis

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Articles related to Panniculitis:

(show top 50) (show all 1594)
# Title Authors Year
1
Distinctive lupus panniculitis of scalp with linear alopecia along Blaschko's lines: a review of the literature. ( 30074627 )
2019
2
Polymyositis with antisynthetase syndrome presented with lobular panniculitis: A case report. ( 30656025 )
2019
3
Pembrolizumab-induced sarcoid granulomatous panniculitis and bullous pemphigoid in a single patient. ( 30997084 )
2019
4
Sterile Pyogranulomatous Dermatitis and Panniculitis. ( 30390792 )
2019
5
Extensive Persistent Panniculitis in the Context of Dermatomyositis. ( 30998572 )
2019
6
A case of extramedullary hematopoiesis presenting as hemorrhagic panniculitis and evolving in acute myeloid leukemia. ( 31095750 )
2019
7
Pancreatic panniculitis in active systemic lupus erythematosus. ( 31081550 )
2019
8
Histoplasma panniculitis in a patient with systemic lupus erythematosus. ( 30726473 )
2019
9
Panniculitis in childhood-onset systemic lupus erythematosus: a multicentric cohort study. ( 30658703 )
2019
10
Subcutaneous Panniculitis-Like T-Cell Lymphoma With Granulomas as the Predominant Feature. ( 30908292 )
2019
11
Subcutaneous panniculitis-like T-cell lymphoma in a 25-year-old male patient with sickle cell disease. ( 30944066 )
2019
12
Epidemiology of primary cutaneous gamma/delta T-cell lymphoma and subcutaneous panniculitis-like T-cell lymphoma in the United States from 2006-2015: A Surveillance, Epidemiology, and End Results-18 analysis. ( 30951189 )
2019
13
Cutaneous mantle cell lymphoma histomorphologically mimicking subcutaneous panniculitis-like T-cell lymphoma: Case report. ( 30957249 )
2019
14
Successful treatment of a rare subcutaneous panniculitis-like T-cell lymphoma: An unusual case report and literature review. ( 30884048 )
2019
15
Frequent germline mutations of HAVCR2 in sporadic subcutaneous panniculitis-like T-cell lymphoma. ( 30792187 )
2019
16
Treatment of Facial Lipoatrophy Secondary to Subcutaneous Panniculitis-Like T-Cell Lymphoma. ( 30829756 )
2019
17
Pediatric Subcutaneous Panniculitis-like T-Cell Lymphoma With Hemophagocytosis Showing Complete Resolution With the BFM90 Protocol: Case Report and Review of Literature. ( 30730380 )
2019
18
Clinicopathologic, immunophenotypic, and molecular analysis of subcutaneous panniculitis-like T-cell lymphoma: A retrospective study in a tertiary care center. ( 30350476 )
2019
19
Panniculitis and vitiligo occurring during BRAF and MEK inhibitors combination in advanced melanoma patients: Potential predictive role of treatment efficacy. ( 30939167 )
2019
20
Pancreatitis panniculitis polyarthritis syndrome with multiple bone infarcts. ( 30351366 )
2019
21
Herpes infection: from skin to panniculitis involvement. ( 28895377 )
2019
22
Vemurafenib-induced histiocytoid neutrophilic panniculitis simulating myeloid leukaemia cutis. ( 30426827 )
2019
23
Author Correction: Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome. ( 30429576 )
2019
24
Equestrian cold panniculitis in a cold-storage-room worker. ( 30628122 )
2019
25
Familial lupus panniculitis: two cases, same diagnosis, what evolution? ( 30636398 )
2019
26
Post-erysipela panniculitis ossificans of the lower leg treated with pentoxifylline. ( 30638288 )
2019
27
Mesenteric panniculitis: comparison of computed tomography findings in patients with and without malignancy. ( 30643446 )
2019
28
A case of erythema nodosum-like panniculitis induced by nivolumab in a patient with oesophageal cancer. ( 30656640 )
2019
29
Neutrophilic Panniculitis in a child with MYSM1 deficiency. ( 30746751 )
2019
30
The mesenteric panniculitis: a truly idiopathic disease? ( 30759974 )
2019
31
Panniculitis with an unusual diagnosis. ( 30932212 )
2019
32
Pancreatic panniculitis with polyarthritis (PPP syndrome). ( 30994265 )
2019
33
A case of mesenteric panniculitis associated with metastatic poorly differentiated cancer of unknown primary site. ( 31001427 )
2019
34
Factitial Panniculitis Associated With Cosmetic Filler. ( 31054609 )
2019
35
Pretibial Panniculitis Ossificans-A Rare but Significant Diagnosis. ( 31079981 )
2019
36
Eosinophilic panniculitis associated with toxocariasis in a child. ( 31090841 )
2019
37
Pancreatic panniculitis as a presentation symptom of acinar cell carcinoma. ( 29527901 )
2018
38
Pancreatic acinar cell carcinoma-induced panniculitis. ( 30128347 )
2018
39
Geometric alopecia associated with lupus erythematosus panniculitis of the scalp: a case series of nine Korean patients. ( 29619994 )
2018
40
Alpha-1 antitrypsin deficiency panniculitis: clinical and pathologic characteristics of 10 cases. ( 29707779 )
2018
41
Cutaneous Manifestation of Alpha-1 Antitrypsin Deficiency: A Case of Panniculitis. ( 30078886 )
2018
42
Pancreatic panniculitis as the initial presentation of intrahepatic cholangiocarcinoma. ( 30023419 )
2018
43
Lobular panniculitis associated with chikungunya fever: A case report. ( 30406015 )
2018
44
Cytophagic Histiocytic Panniculitis Associated with Myelodysplastic Syndrome. ( 30226527 )
2018
45
Analysis of Bacterial and Fungal Nucleic Acid in Canine Sterile Granulomatous and Pyogranulomatous Dermatitis and Panniculitis. ( 29145794 )
2018
46
Dermatomyositis panniculitis: a clinicopathological and immunohistochemical study of 18 cases. ( 29524269 )
2018
47
Panniculitis associated with amyopathic dermatomyositis. ( 29641712 )
2018
48
Panniculitis, A Rare Presentation of Onset and Exacerbation of Juvenile Dermatomyositis: A Case Report and Literature Review. ( 30632528 )
2018
49
Composite cutaneous lymphoma of diffuse large B-cell lymphoma-leg type and subcutaneous panniculitis-like T-cell lymphoma. ( 29851123 )
2018
50
Hashimoto's encephalopathy in a patient with septal panniculitis: a case report. ( 30570247 )
2018
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Variations for Panniculitis

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Expression for Panniculitis

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Search GEO for disease gene expression data for Panniculitis.
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Pathways for Panniculitis

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Pathways related to Panniculitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Apoptosis and survival Caspase cascade 23
Show member pathways
 11.76 FAS GZMB PSMB8
2
NF-kappaB Signaling 4
11.74 BTK FAS GZMB HAVCR2 IFNG NCAM1
3
Apoptosis and Autophagy 4
11.6 FAS GZMB TIA1
4
Photodynamic therapy-induced AP-1 survival signaling. 1
11.08 FAS IFNG
5
Innate Lymphoid Cell Differentiation Pathways 66
11.03 GZMB IFNG NCAM1
6
African trypanosomiasis 38
10.82 FAS IFNG
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GO Terms for Panniculitis

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Cellular components related to Panniculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immunological synapse GO:0001772 8.62 GZMB HAVCR2

Biological processes related to Panniculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.5 BTK HAVCR2 IFNG
2 immune system process GO:0002376 9.46 BTK HAVCR2 OTULIN PSMB8
3 extrinsic apoptotic signaling pathway GO:0097191 9.26 FAS IFNG
4 apoptotic process GO:0006915 9.02 BTK FAS GZMB IFNG TIA1
5 negative regulation of interleukin-2 production GO:0032703 8.96 HAVCR2 NAV3
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Sources for Panniculitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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