MCID: PNN001
MIFTS: 52

Panniculitis

Categories: Muscle diseases, Skin diseases

Aliases & Classifications for Panniculitis

MalaCards integrated aliases for Panniculitis:

Name: Panniculitis 12 77 30 56 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:1526
ICD9CM 36 729.3 729.30
MeSH 45 D015434
NCIt 51 C112112
SNOMED-CT 69 22125009
ICD10 34 M79.3
UMLS 74 C0030326

Summaries for Panniculitis

MalaCards based summary : Panniculitis is related to subcutaneous panniculitis-like t-cell lymphoma and peripheral t-cell lymphoma, and has symptoms including pruritus, myalgia and exanthema. An important gene associated with Panniculitis is OTULIN (OTU Deubiquitinase With Linear Linkage Specificity), and among its related pathways/superpathways are Signaling by GPCR and Antigen processing-Cross presentation. The drugs Vincristine and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and neutrophil, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 77 Panniculitis is a group of diseases whose hallmark is inflammation of subcutaneous adipose tissue (the... more...

Related Diseases for Panniculitis

Diseases related to Panniculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 334)
# Related Disease Score Top Affiliating Genes
1 subcutaneous panniculitis-like t-cell lymphoma 33.6 GZMB NAV3 NCAM1 TIA1
2 peripheral t-cell lymphoma 29.8 GZMB NCAM1 TIA1
3 b-cell lymphomas 29.7 BTK FAS TIA1
4 cutaneous t cell lymphoma 29.6 GZMB IFNG TIA1
5 hemophagocytic lymphohistiocytosis 29.6 FAS GZMB IFNG
6 graft-versus-host disease 28.9 FAS GZMB IFNG
7 nodular nonsuppurative panniculitis 12.8
8 lupus erythematosus panniculitis 12.5
9 autoinflammation, panniculitis, and dermatosis syndrome 12.4
10 cytophagic histiocytic panniculitis 12.3
11 infantile onset panniculitis with uveitis and systemic granulomatosis 12.1
12 panniculitis-induced localized lipodystrophy 12.0
13 localized lipodystrophy 11.9
14 lipodermatosclerosis 11.9
15 proteasome-associated autoinflammatory syndrome 1 11.8
16 alpha-1-antitrypsin deficiency 11.6
17 igg4-related mesenteritis 11.6
18 peritonitis 11.5
19 acquired generalized lipodystrophy 11.3
20 proteasome-associated autoinflammatory syndrome 3 11.2
21 autoimmune lymphoproliferative syndrome 11.0
22 erythema nodosum, idiopathic 11.0
23 lymphoma 10.8
24 lupus erythematosus 10.6
25 pancreatitis 10.5
26 dermatomyositis 10.4
27 systemic lupus erythematosus 10.3
28 vasculitis 10.3
29 lichen sclerosus et atrophicus 10.3 GZMB TIA1
30 lymphomatoid granulomatosis 10.3 GZMB TIA1
31 viral esophagitis 10.3 GZMB TIA1
32 primary cutaneous anaplastic large cell lymphoma 10.3 GZMB TIA1
33 fasciitis 10.3
34 composite lymphoma 10.3 GZMB TIA1
35 hepatosplenic t-cell lymphoma 10.3 GZMB TIA1
36 arthritis 10.3
37 choriocarcinoma of the testis 10.3 GZMB TIA1
38 giardiasis 10.3 GZMB TIA1
39 lethal midline granuloma 10.3 NCAM1 TIA1
40 dermatitis 10.3
41 infiltrating lipoma 10.2 GZMB TIA1
42 necrotizing sialometaplasia 10.2 GZMB TIA1
43 cardiac sarcoidosis 10.2 PSMB8 PSMB9
44 rhinoscleroma 10.2 NCAM1 SERPINA1
45 t-cell large granular lymphocyte leukemia 10.2 GZMB NCAM1
46 angioimmunoblastic t-cell lymphoma 10.2 GZMB TIA1
47 multiple sclerosis 10.2
48 alopecia 10.2
49 acinar cell carcinoma 10.2
50 cystadenofibroma 10.2 NCAM1 SERPINA1

Graphical network of the top 20 diseases related to Panniculitis:



Diseases related to Panniculitis

Symptoms & Phenotypes for Panniculitis

UMLS symptoms related to Panniculitis:


pruritus, myalgia, exanthema, decreased adipose tissue, other musculoskeletal symptoms referable to limbs, pain in limb, integumentary system signs and symptoms

GenomeRNAi Phenotypes related to Panniculitis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.72 FAS GZMB NAV3 PSMB8 PSMB9 TIA1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.72 FAS GZMB NAV3 PSMB8 PSMB9 TIA1

MGI Mouse Phenotypes related to Panniculitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.5 BTK FAS IFNG OTULIN PSMB8 PSMB9
2 neoplasm MP:0002006 9.02 BTK FAS IFNG PSMB8 PSMB9

Drugs & Therapeutics for Panniculitis

Drugs for Panniculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 89)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 4 2068-78-2, 57-22-7 5978
2
Ifosfamide Approved Phase 4 3778-73-2 3690
3
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
4
Epirubicin Approved Phase 4 56420-45-2 41867
5
Cyclophosphamide Approved, Investigational Phase 4 6055-19-2, 50-18-0 2907
6
Cisplatin Approved Phase 4 15663-27-1 441203 84093 2767
7
Etoposide Approved Phase 4 33419-42-0 36462
8
Gemcitabine Approved Phase 4,Phase 1,Phase 2 95058-81-4 60750
9
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
10
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
11
Methyltestosterone Approved Phase 4 58-18-4 6010
12
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
13
Testosterone Approved, Experimental, Investigational Phase 4 58-22-0, 481-30-1 6013 10204
14
Testosterone enanthate Approved Phase 4 315-37-7 9416
15
leucovorin Approved Phase 4,Phase 1,Phase 2 58-05-9 6006 143
16
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
17
Mechlorethamine Approved, Investigational Phase 4 51-75-2 4033
18
Doxorubicin Approved, Investigational Phase 4 23214-92-8 31703
19
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 59-30-3 6037
20
Pirarubicin Investigational Phase 4 72496-41-4
21
Doxil Approved June 1999 Phase 4 31703
22
Isophosphamide mustard Phase 4 0
23 Anti-Bacterial Agents Phase 4,Phase 1
24 Anti-Inflammatory Agents Phase 4
25 Antineoplastic Agents, Alkylating Phase 4
26 Etoposide phosphate Phase 4
27 Hormones Phase 4,Phase 2,Not Applicable
28 BB 1101 Phase 4
29 Immunosuppressive Agents Phase 4,Phase 1,Phase 2
30 Antineoplastic Agents, Hormonal Phase 4
31 Hormone Antagonists Phase 4
32 Immunologic Factors Phase 4,Phase 1,Phase 2
33 Topoisomerase Inhibitors Phase 4
34 Alkylating Agents Phase 4
35 Antibiotics, Antitubercular Phase 4,Phase 1
36 Antimitotic Agents Phase 4
37 Antineoplastic Agents, Phytogenic Phase 4
38 Antirheumatic Agents Phase 4,Phase 1
39 glucocorticoids Phase 4
40 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
41 Testosterone 17 beta-cypionate Phase 4
42 insulin Phase 4
43 Anabolic Agents Phase 4
44 Insulin, Globin Zinc Phase 4
45 Androgens Phase 4
46 Vitamin B Complex Phase 4,Phase 1,Phase 2
47 Antimetabolites Phase 4,Phase 1,Phase 2
48 Antimetabolites, Antineoplastic Phase 4,Phase 1,Phase 2
49 Vitamin B9 Phase 4,Phase 1,Phase 2
50 Folate Phase 4,Phase 1,Phase 2

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 CEOP/IVE/GDP Compared With CEOP as the First-line Therapy for Newly Diagnosed Adult Patients With PTCL Unknown status NCT02533700 Phase 4 CEOP/IVE/GDP chemotherapy regimen;CEOP chemotherapy regimen for 6 cycles
2 Testosterone Replacement in Metabolic Syndrome and Inflammation Completed NCT01123278 Phase 4 Testosterone;Placebo
3 CTOP/ITE/MTX Compared With CHOP as the First-line Therapy for Newly Diagnosed Young Patients With T Cell Lymphoma Active, not recruiting NCT01746992 Phase 4 Cyclophosphamide 750mg/m2;Vincristine 1.4mg/m2;Doxorubicin 50mg/m2;prednisone 60mg/m2;ifosfamide 2000mg/m2;pirarubicin 50mg/m2;pirarubicin 25mg/m2;Etoposide phosphate 100mg/m2;methotrexate 1500mg/m2
4 Effectiveness and Safety of Autologous ADRC for Treatment of Degenerative Damage of Knee Articular Cartilage Completed NCT02219113 Phase 1, Phase 2
5 Study of Pralatrexate & Gemcitabine With B12 & Folic Acid to Treat Relapsed/Refractory Lymphoproliferative Malignancies Completed NCT00481871 Phase 1, Phase 2 Pralatrexate Injection;Gemcitabine Hydrochloride
6 A Phase II Study to Evaluate Safety and Efficacy of ALX-0061 in Subjects With Systemic Lupus Erythematosus Completed NCT02437890 Phase 2
7 Effectiveness and Safety of Autologous ADRC for Treatment of Anterior Cruciate Ligament Partial Rupture Enrolling by invitation NCT02469792 Phase 1, Phase 2
8 Autologous Stromal Vascular Fraction of Cells for Treatment of Knee Articular Cartilage Dystrophy Enrolling by invitation NCT02827851 Phase 2
9 Vitamin D Status, Disease Specific and Quality of Life Outcomes in Patients With Cutaneous Lupus Terminated NCT01498406 Phase 2
10 Phase 1 Trial of Siplizumab and Dose-Adjusted EPOCH-Rituximab in T- and NK-Cell Lymphomas Active, not recruiting NCT01445535 Phase 1 EPOCH
11 Everolimus and Bortezomib in Treating Patients With Relapsed or Refractory Lymphoma Terminated NCT00671112 Phase 1 Bortezomib;Everolimus
12 Inflammation and Oxidative Stress of Adipose Tissue in Sleep Apnea Syndrome Unknown status NCT01196845 Not Applicable
13 Mesenteric Panniculitis : Review of Consecutive Abdominal MDCT Examinations With a Matched-pair Analysis Completed NCT03316001
14 Characterization of Transient Alterations of Cutaneous Sensory Nerve Function by Cryolipolysis Completed NCT01673113 Not Applicable
15 Diet Induced Weight Loss to Reduce Inflammation in Obese Women Completed NCT01699906 Not Applicable
16 GENETIC SUSCEPTIBILITY FACTOR AS A PREDICTOR OF TYPE 2 DIABETES REMISSION AND WEIGHT LOSS AFTER BARIATRIC SURGERY Completed NCT02405949
17 T-Cell Project: Prospective Collection of Data in Patients With Peripheral T-Cell Lymphoma Recruiting NCT01142674
18 Leipzig Adipose Tissue Childhood Cohort Recruiting NCT02208141
19 Cholecalciferol in Improving Survival in Patients With Newly Diagnosed Cancer With Vitamin D Insufficiency Recruiting NCT01787409 Not Applicable
20 Study of the Efficacy of 532nm Laser and 1064 nm Laser in the Treatment of Cutaneous Lupus Erythematous Versus Topical Corticosteroids Alone Recruiting NCT03639857 Not Applicable Topical corticosteroid
21 Salvia Hispanica Seed in Reducing Risk of Disease Recurrence in Patients With Non-Hodgkin Lymphoma Active, not recruiting NCT02652715 Not Applicable
22 Prospective Study of Functional and Quality of Life Outcomes in Panniculectomy Patients Terminated NCT01464658 Not Applicable

Search NIH Clinical Center for Panniculitis

Cochrane evidence based reviews: panniculitis

Genetic Tests for Panniculitis

Genetic tests related to Panniculitis:

# Genetic test Affiliating Genes
1 Panniculitis 30

Anatomical Context for Panniculitis

MalaCards organs/tissues related to Panniculitis:

42
T Cells, Skin, Neutrophil, Breast, Pancreas, Bone, Liver

Publications for Panniculitis

Articles related to Panniculitis:

(show top 50) (show all 1583)
# Title Authors Year
1
Polymyositis with antisynthetase syndrome presented with lobular panniculitis: A case report. ( 30656025 )
2019
2
Sterile Pyogranulomatous Dermatitis and Panniculitis. ( 30390792 )
2019
3
Hematopoietic stem cell transplantation for subcutaneous panniculitis-like T-cell lymphoma: single center experience in an Asian population. ( 30547418 )
2019
4
Histoplasma panniculitis in a patient with systemic lupus erythematosus. ( 30726473 )
2019
5
Panniculitis in childhood-onset systemic lupus erythematosus: a multicentric cohort study. ( 30658703 )
2019
6
Subcutaneous Panniculitis-Like T-Cell Lymphoma With Granulomas as the Predominant Feature. ( 30908292 )
2019
7
Successful treatment of a rare subcutaneous panniculitis-like T-cell lymphoma: An unusual case report and literature review. ( 30884048 )
2019
8
Frequent germline mutations of HAVCR2 in sporadic subcutaneous panniculitis-like T-cell lymphoma. ( 30792187 )
2019
9
Treatment of Facial Lipoatrophy Secondary to Subcutaneous Panniculitis-Like T-Cell Lymphoma. ( 30829756 )
2019
10
Pediatric Subcutaneous Panniculitis-like T-Cell Lymphoma With Hemophagocytosis Showing Complete Resolution With the BFM90 Protocol: Case Report and Review of Literature. ( 30730380 )
2019
11
Cytophagic Histiocytic Panniculitis Associated with Myelodysplastic Syndrome. ( 30226527 )
2019
12
Pancreatitis panniculitis polyarthritis syndrome with multiple bone infarcts. ( 30351366 )
2019
13
The mesenteric panniculitis: a truly idiopathic disease? ( 30759974 )
2019
14
Vemurafenib-induced histiocytoid neutrophilic panniculitis simulating myeloid leukaemia cutis. ( 30426827 )
2019
15
Equestrian cold panniculitis in a cold-storage-room worker. ( 30628122 )
2019
16
Familial lupus panniculitis: two cases, same diagnosis, what evolution? ( 30636398 )
2019
17
Post-erysipela panniculitis ossificans of the lower leg treated with pentoxifylline. ( 30638288 )
2019
18
Mesenteric panniculitis: comparison of computed tomography findings in patients with and without malignancy. ( 30643446 )
2019
19
A case of erythema nodosum-like panniculitis induced by nivolumab in a patient with oesophageal cancer. ( 30656640 )
2019
20
Neutrophilic Panniculitis in a child with MYSM1 deficiency. ( 30746751 )
2019
21
Livedo Racemosa, Reticulated Ulcerations, Panniculitis and Violaceous Plaques in a 46-year-old Woman. ( 29441299 )
2018
22
Septolobular panniculitis in disseminated Lyme borreliosis. ( 29293267 )
2018
23
Pancreatic panniculitis: the "bright" side of the moon in solid cancer patients. ( 29301491 )
2018
24
Inherited Immunodeficiency: A New Association With Early-Onset Childhood Panniculitis. ( 29610179 )
2018
25
Panniculitis associated with amyopathic dermatomyositis. ( 29641712 )
2018
26
Composite cutaneous lymphoma of diffuse large B-cell lymphoma-leg type and subcutaneous panniculitis-like T-cell lymphoma. ( 29851123 )
2018
27
Analysis of Bacterial and Fungal Nucleic Acid in Canine Sterile Granulomatous and Pyogranulomatous Dermatitis and Panniculitis. ( 29145794 )
2018
28
Diffuse granulomatous panniculitis associated with anti PD-1 antibody therapy. ( 29296642 )
2018
29
Ultrasound of pancreatic panniculitis. ( 29736975 )
2018
30
Spontaneous Resolution of Idiopathic Panniculitis: Role of <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Diagnosis and follow-up. ( 29962727 )
2018
31
Alpha-1 antitrypsin deficiency panniculitis: clinical and pathologic characteristics of 10 cases. ( 29707779 )
2018
32
Subcutaneous Panniculitis-Like T-Cell Lymphoma Versus Lupus Erythematosus Panniculitis: Distinction by Means of the Periadipocytic Cell Proliferation Index. ( 29742552 )
2018
33
Recurrent lupus profundus-like panniculitis associated with streptococcal throat infections in an immunocompetent child. ( 29693070 )
2018
34
Lupus erythematosus panniculitis in a 10-year-old female child with severe systemic lupus erythematosus: A case report. ( 29504978 )
2018
35
Cold Panniculitis After Ice Therapy for Supraventricular Tachycardia. ( 29698337 )
2018
36
Pancreatic panniculitis: A case series from a tertiary university hospital in Spain. ( 29741276 )
2018
37
Mesenteric Panniculitis Presenting as Fever of Unknown Etiology in a Patient with History of Abdominal Surgery. ( 29670775 )
2018
38
A Case of Refractory Subcutaneous Panniculitis-like T-cell Lymphoma with Bone Marrow and Lung Involvement Treated Successfully with Oral Etoposide. ( 29881869 )
2018
39
Chronic pancreatitis with multiple pseudocysts and pancreatic panniculitis: A case report. ( 29851820 )
2018
40
Intravascular large B-cell lymphoma presenting as panniculitis clinically: a case report. ( 29568849 )
2018
41
Pancreatic panniculitis as a presentation symptom of acinar cell carcinoma. ( 29527901 )
2018
42
Cold panniculitis: Adverse cutaneous effect of whole-body cryotherapy. ( 29693065 )
2018
43
Breast panniculitis with liquefactive fat necrosis: A case report. ( 29904432 )
2018
44
An Autopsy Case of Mesenteric Panniculitis with Massive Pleural Effusions. ( 29298971 )
2018
45
Geometric alopecia associated with lupus erythematosus panniculitis of the scalp: a case series of nine Korean patients. ( 29619994 )
2018
46
Mesenteric Panniculitis-First Case Series After Bariatric Surgery. ( 29313276 )
2018
47
Evaluation of mesenteric panniculitis with computed tomography: benign condition or paraneoplastic syndrome? ( 29914254 )
2018
48
The coexistence of lupus erythematosus panniculitis and subcutaneous panniculitis-like T-cell lymphoma in the same patient. ( 29892661 )
2018
49
A case of deadly panniculitis. ( 29970609 )
2018
50
Panniculitis Due to Atypical Mycobacteria After Mesotherapy. ( 29859618 )
2018

Variations for Panniculitis

Expression for Panniculitis

Search GEO for disease gene expression data for Panniculitis.

Pathways for Panniculitis

GO Terms for Panniculitis

Cellular components related to Panniculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.86 BTK FAS GZMB NCAM1 OTULIN PSMB8
2 proteasome core complex GO:0005839 9.16 PSMB8 PSMB9
3 proteasome core complex, beta-subunit complex GO:0019774 8.96 PSMB8 PSMB9
4 spermatoproteasome complex GO:1990111 8.62 PSMB8 PSMB9

Biological processes related to Panniculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.67 GZMB OTULIN PSMB8 PSMB9
2 immune system process GO:0002376 9.46 BTK OTULIN PSMB8 PSMB9
3 extrinsic apoptotic signaling pathway GO:0097191 9.32 FAS IFNG
4 proteasomal protein catabolic process GO:0010498 9.26 PSMB8 PSMB9
5 apoptotic process GO:0006915 9.02 BTK FAS GZMB IFNG TIA1
6 proteasomal ubiquitin-independent protein catabolic process GO:0010499 8.96 PSMB8 PSMB9

Molecular functions related to Panniculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.26 GZMB OTULIN PSMB8 PSMB9
2 threonine-type endopeptidase activity GO:0004298 8.62 PSMB8 PSMB9

Sources for Panniculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
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45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
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55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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