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MCID: PNN001
MIFTS: 49

Panniculitis

Categories: Skin diseases, Muscle diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Panniculitis

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MalaCards integrated aliases for Panniculitis:

Name: Panniculitis 12 76 29 55 44 15 73

Classifications:

MalaCards categories:
Anatomical: Skin diseases Muscle diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:1526
ICD10 33 M79.3
ICD9CM 35 729.3 729.30
MeSH 44 D015434
NCIt 50 C112112
UMLS 73 C0030326
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Summaries for Panniculitis

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MalaCards based summary : Panniculitis is related to subcutaneous panniculitis-like t-cell lymphoma and peripheral t-cell lymphoma, and has symptoms including exanthema, other musculoskeletal symptoms referable to limbs and pain in limb. An important gene associated with Panniculitis is OTULIN (OTU Deubiquitinase With Linear Linkage Specificity), and among its related pathways/superpathways are NF-kappaB Signaling and IL-2 Signaling Pathway. The drugs Cisplatin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and neutrophil, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 76 Panniculitis is a group of diseases whose hallmark is inflammation of subcutaneous adipose tissue (the... more...

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Related Diseases for Panniculitis

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Diseases related to Panniculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 285)
# Related Disease Score Top Affiliating Genes
1 subcutaneous panniculitis-like t-cell lymphoma 32.1 GZMB MYC NAV3 NCAM1 TIA1
2 peripheral t-cell lymphoma 29.8 GZMB NCAM1 TIA1
3 cutaneous t cell lymphoma 29.1 GZMB IFNG TIA1
4 hemophagocytic lymphohistiocytosis 28.7 FAS GZMB IFNG
5 b-cell lymphomas 28.4 BTK FAS MYC TIA1
6 lymphoma, non-hodgkin, familial 28.3 FAS GZMB MYC
7 nodular nonsuppurative panniculitis 12.6
8 lupus erythematosus panniculitis 12.3
9 autoinflammation, panniculitis, and dermatosis syndrome 12.3
10 cytophagic histiocytic panniculitis 12.1
11 infantile onset panniculitis with uveitis and systemic granulomatosis 12.0
12 lipodermatosclerosis 11.9
13 panniculitis-induced localized lipodystrophy 11.8
14 localized lipodystrophy 11.8
15 autoinflammation, lipodystrophy, and dermatosis syndrome 11.7
16 alpha-1-antitrypsin deficiency 11.4
17 igg4-related mesenteritis 11.3
18 peritonitis 11.3
19 acquired generalized lipodystrophy 11.2
20 autoimmune lymphoproliferative syndrome 10.9
21 erythema nodosum, idiopathic 10.9
22 lichen sclerosus et atrophicus 10.7 GZMB TIA1
23 lymphomatoid granulomatosis 10.7 GZMB TIA1
24 viral esophagitis 10.7 GZMB TIA1
25 primary cutaneous anaplastic large cell lymphoma 10.7 GZMB TIA1
26 natural killer cell leukemia 10.7 GZMB TIA1
27 composite lymphoma 10.6 GZMB TIA1
28 lymphoma 10.6
29 hepatosplenic t-cell lymphoma 10.6 GZMB TIA1
30 choriocarcinoma of the testis 10.6 GZMB TIA1
31 giardiasis 10.6 GZMB TIA1
32 infiltrating lipoma 10.6 GZMB TIA1
33 lethal midline granuloma 10.6 NCAM1 TIA1
34 necrotizing sialometaplasia 10.5 GZMB TIA1
35 rhinoscleroma 10.5 NCAM1 SERPINA1
36 t-cell large granular lymphocyte leukemia 10.5 GZMB NCAM1
37 lymphatic system cancer 10.5 MYC TIA1
38 pancreatitis 10.5
39 lupus erythematosus 10.4
40 cystadenofibroma 10.4 NCAM1 SERPINA1
41 fibrosarcoma of bone 10.3 MYC SERPINA1
42 plasma cell neoplasm 10.3 MYC NCAM1
43 plasma protein metabolism disease 10.3 BTK SERPINA1
44 acute necrotizing encephalitis 10.3 GZMB IFNG
45 lung lymphoma 10.3 GZMB NCAM1
46 orbit lymphoma 10.2 GZMB NCAM1 TIA1
47 parasitic ichthyosporea infectious disease 10.2 NCAM1 SERPINA1 TIA1
48 rhinosporidiosis 10.2 NCAM1 SERPINA1 TIA1
49 erythema multiforme 10.1 GZMB IFNG
50 dermatomyositis 10.1

Graphical network of the top 20 diseases related to Panniculitis:



Diseases related to Panniculitis
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Symptoms & Phenotypes for Panniculitis

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UMLS symptoms related to Panniculitis:


exanthema, other musculoskeletal symptoms referable to limbs, pain in limb, pruritus, myalgia, integumentary system signs and symptoms, decreased adipose tissue

GenomeRNAi Phenotypes related to Panniculitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.66 FAS GZMB NAV3 PSMB8 TIA1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.66 BTK FAS GZMB MYC NAV3 PSMB8

MGI Mouse Phenotypes related to Panniculitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.5 BTK FAS IFNG MYC OTULIN PSMB8
2 neoplasm MP:0002006 9.02 BTK FAS IFNG MYC PSMB8
Sources

Drugs & Therapeutics for Panniculitis

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Drugs for Panniculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 82)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 4 15663-27-1 84093 441203 2767
2
Cyclophosphamide Approved, Investigational Phase 4 50-18-0, 6055-19-2 2907
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
4
Epirubicin Approved Phase 4 56420-45-2 41867
5
Etoposide Approved Phase 4 33419-42-0 36462
6
Gemcitabine Approved Phase 4,Phase 1,Phase 2 95058-81-4 60750
7
Ifosfamide Approved Phase 4 3778-73-2 3690
8
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
9
Vincristine Approved, Investigational Phase 4 2068-78-2, 57-22-7 5978
10
Methyltestosterone Approved Phase 4 58-18-4 6010
11
Testosterone Approved, Investigational Phase 4 58-22-0 6013
12
Testosterone enanthate Approved Phase 4 315-37-7 9416
13
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
14
Doxorubicin Approved, Investigational Phase 4 23214-92-8 31703
15
Mechlorethamine Approved, Investigational Phase 4 51-75-2 4033
16
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
17
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 59-30-3 6037
18
leucovorin Approved, Nutraceutical Phase 4,Phase 1,Phase 2 58-05-9 143 6006
19
Doxil Approved June 1999 Phase 4 31703
20
Pirarubicin Investigational Phase 4 72496-41-4
21 Alkylating Agents Phase 4
22 Anti-Bacterial Agents Phase 4,Phase 1
23 Antibiotics, Antitubercular Phase 4,Phase 1
24 Anti-Inflammatory Agents Phase 4
25 Antimitotic Agents Phase 4
26 Antineoplastic Agents, Alkylating Phase 4
27 Antineoplastic Agents, Hormonal Phase 4
28 Antineoplastic Agents, Phytogenic Phase 4
29 Antirheumatic Agents Phase 4,Phase 1
30 BB 1101 Phase 4
31 Dexamethasone acetate Phase 4 1177-87-3
32 Etoposide phosphate Phase 4
33 glucocorticoids Phase 4
34 Hormone Antagonists Phase 4
35 Hormones Phase 4
36 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
37 Immunosuppressive Agents Phase 4,Phase 1,Phase 2
38
Isophosphamide mustard Phase 4 0
39 Topoisomerase Inhibitors Phase 4
40 Anabolic Agents Phase 4
41 Androgens Phase 4
42 insulin Phase 4
43 Insulin, Globin Zinc Phase 4
44 Testosterone 17 beta-cypionate Phase 4
45 Antimetabolites Phase 4,Phase 1,Phase 2
46 Antimetabolites, Antineoplastic Phase 4,Phase 1,Phase 2
47 Folic Acid Antagonists Phase 4,Phase 1,Phase 2
48 Vitamin B Complex Phase 4,Phase 1,Phase 2
49 Dermatologic Agents Phase 4
50 Nucleic Acid Synthesis Inhibitors Phase 4

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 CEOP/IVE/GDP Compared With CEOP as the First-line Therapy for Newly Diagnosed Adult Patients With PTCL Unknown status NCT02533700 Phase 4 CEOP/IVE/GDP chemotherapy regimen;CEOP chemotherapy regimen for 6 cycles
2 Testosterone Replacement in Metabolic Syndrome and Inflammation Completed NCT01123278 Phase 4 Testosterone;Placebo
3 CTOP/ITE/MTX Compared With CHOP as the First-line Therapy for Newly Diagnosed Young Patients With T Cell Lymphoma Active, not recruiting NCT01746992 Phase 4 Cyclophosphamide 750mg/m2;Vincristine 1.4mg/m2;Doxorubicin 50mg/m2;prednisone 60mg/m2;ifosfamide 2000mg/m2;pirarubicin 50mg/m2;pirarubicin 25mg/m2;Etoposide phosphate 100mg/m2;methotrexate 1500mg/m2
4 Effectiveness and Safety of Autologous ADRC for Treatment of Degenerative Damage of Knee Articular Cartilage Completed NCT02219113 Phase 1, Phase 2
5 Study of Pralatrexate & Gemcitabine With B12 & Folic Acid to Treat Relapsed/Refractory Lymphoproliferative Malignancies Completed NCT00481871 Phase 1, Phase 2 Pralatrexate Injection;Gemcitabine Hydrochloride
6 Effectiveness and Safety of Autologous ADRC for Treatment of Anterior Cruciate Ligament Partial Rupture Enrolling by invitation NCT02469792 Phase 1, Phase 2
7 Autologous Stromal Vascular Fraction of Cells for Treatment of Knee Articular Cartilage Dystrophy Enrolling by invitation NCT02827851 Phase 2
8 Vitamin D Status, Disease Specific and Quality of Life Outcomes in Patients With Cutaneous Lupus Terminated NCT01498406 Phase 2
9 Phase 1 Trial of Siplizumab and Dose-Adjusted EPOCH-Rituximab in T- and NK-Cell Lymphomas Active, not recruiting NCT01445535 Phase 1 EPOCH
10 Everolimus and Bortezomib in Treating Patients With Relapsed or Refractory Lymphoma Terminated NCT00671112 Phase 1 Bortezomib;Everolimus
11 Inflammation and Oxidative Stress of Adipose Tissue in Sleep Apnea Syndrome Unknown status NCT01196845 Not Applicable
12 Mesenteric Panniculitis : Review of Consecutive Abdominal MDCT Examinations With a Matched-pair Analysis Completed NCT03316001
13 Characterization of Transient Alterations of Cutaneous Sensory Nerve Function by Cryolipolysis Completed NCT01673113 Not Applicable
14 Diet Induced Weight Loss to Reduce Inflammation in Obese Women Completed NCT01699906 Not Applicable
15 GENETIC SUSCEPTIBILITY FACTOR AS A PREDICTOR OF TYPE 2 DIABETES REMISSION AND WEIGHT LOSS AFTER BARIATRIC SURGERY Completed NCT02405949
16 T-Cell Project: Prospective Collection of Data in Patients With Peripheral T-Cell Lymphoma Recruiting NCT01142674
17 Leipzig Adipose Tissue Childhood Cohort Recruiting NCT02208141
18 Salvia Hispanica Seed in Reducing Risk of Disease Recurrence in Patients With Non-Hodgkin Lymphoma Recruiting NCT02652715 Not Applicable
19 Cholecalciferol in Improving Survival in Patients With Newly Diagnosed Cancer With Vitamin D Insufficiency Recruiting NCT01787409 Not Applicable
20 Prospective Study of Functional and Quality of Life Outcomes in Panniculectomy Patients Terminated NCT01464658 Not Applicable

Search NIH Clinical Center for Panniculitis

Cochrane evidence based reviews: panniculitis

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Genetic Tests for Panniculitis

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Genetic tests related to Panniculitis:

# Genetic test Affiliating Genes
1 Panniculitis 29
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Anatomical Context for Panniculitis

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MalaCards organs/tissues related to Panniculitis:

41
T Cells, Skin, Neutrophil, Pancreas, Bone, Liver, B Cells
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Publications for Panniculitis

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Articles related to Panniculitis:

(show top 50) (show all 877)
# Title Authors Year
1
Livedo Racemosa, Reticulated Ulcerations, Panniculitis and Violaceous Plaques in a 46-year-old Woman. ( 29441299 )
2018
2
Septolobular panniculitis in disseminated Lyme borreliosis. ( 29293267 )
2018
3
Pancreatic panniculitis: the "bright" side of the moon in solid cancer patients. ( 29301491 )
2018
4
Inherited Immunodeficiency: A New Association With Early-Onset Childhood Panniculitis. ( 29610179 )
2018
5
Panniculitis associated with amyopathic dermatomyositis. ( 29641712 )
2018
6
Composite cutaneous lymphoma of diffuse large B-cell lymphoma-leg type and subcutaneous panniculitis-like T-cell lymphoma. ( 29851123 )
2018
7
Analysis of Bacterial and Fungal Nucleic Acid in Canine Sterile Granulomatous and Pyogranulomatous Dermatitis and Panniculitis. ( 29145794 )
2018
8
Diffuse granulomatous panniculitis associated with anti PD-1 antibody therapy. ( 29296642 )
2018
9
Ultrasound of pancreatic panniculitis. ( 29736975 )
2018
10
Spontaneous Resolution of Idiopathic Panniculitis: Role of <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Diagnosis and follow-up. ( 29962727 )
2018
11
Alpha-1 antitrypsin deficiency panniculitis: clinical and pathologic characteristics of 10 cases. ( 29707779 )
2018
12
Subcutaneous Panniculitis-Like T-Cell Lymphoma Versus Lupus Erythematosus Panniculitis: Distinction by Means of the Periadipocytic Cell Proliferation Index. ( 29742552 )
2018
13
Recurrent lupus profundus-like panniculitis associated with streptococcal throat infections in an immunocompetent child. ( 29693070 )
2018
14
Lupus erythematosus panniculitis in a 10-year-old female child with severe systemic lupus erythematosus: A case report. ( 29504978 )
2018
15
Cold Panniculitis After Ice Therapy for Supraventricular Tachycardia. ( 29698337 )
2018
16
Pancreatic panniculitis: A case series from a tertiary university hospital in Spain. ( 29741276 )
2018
17
Mesenteric Panniculitis Presenting as Fever of Unknown Etiology in a Patient with History of Abdominal Surgery. ( 29670775 )
2018
18
A Case of Refractory Subcutaneous Panniculitis-like T-cell Lymphoma with Bone Marrow and Lung Involvement Treated Successfully with Oral Etoposide. ( 29881869 )
2018
19
Chronic pancreatitis with multiple pseudocysts and pancreatic panniculitis: A case report. ( 29851820 )
2018
20
Intravascular large B-cell lymphoma presenting as panniculitis clinically: a case report. ( 29568849 )
2018
21
Pancreatic panniculitis as a presentation symptom of acinar cell carcinoma. ( 29527901 )
2018
22
Cold panniculitis: Adverse cutaneous effect of whole-body cryotherapy. ( 29693065 )
2018
23
Breast panniculitis with liquefactive fat necrosis: A case report. ( 29904432 )
2018
24
An Autopsy Case of Mesenteric Panniculitis with Massive Pleural Effusions. ( 29298971 )
2018
25
Geometric alopecia associated with lupus erythematosus panniculitis of the scalp: a case series of nine Korean patients. ( 29619994 )
2018
26
Mesenteric Panniculitis-First Case Series After Bariatric Surgery. ( 29313276 )
2018
27
Evaluation of mesenteric panniculitis with computed tomography: benign condition or paraneoplastic syndrome? ( 29914254 )
2018
28
The coexistence of lupus erythematosus panniculitis and subcutaneous panniculitis-like T-cell lymphoma in the same patient. ( 29892661 )
2018
29
A case of deadly panniculitis. ( 29970609 )
2018
30
Panniculitis Due to Atypical Mycobacteria After Mesotherapy. ( 29859618 )
2018
31
Mesenteric panniculitis. ( 28870885 )
2017
32
Self-limiting Ibrutinib-Induced Neutrophilic Panniculitis. ( 28953011 )
2017
33
Pancreatitis, panniculitis, and polyarthritis (PPP) syndrome: MRI features of intraosseous fat necrosis involving the feet and knees. ( 27928580 )
2017
34
An Atypical Presentation of Chronic Atrophic Gastritis: Hemolytic Anemia and Mesenteric Panniculitis. ( 28758037 )
2017
35
Clinical characteristics, differential diagnosis, and treatment outcome of subcutaneous panniculitis-like T-cell lymphoma: a literature review of published Japanese cases. ( 28120776 )
2017
36
Subcutaneous Panniculitis-Like T-Cell Lymphoma Presenting as a Local Inflammation of a Thigh in an 8-Month-Old Child. ( 29085769 )
2017
37
Erythema Nodosum-Like Panniculitis as a False-Positive 18F-FDG PET/CT in Advanced Melanoma Treated With Dabrafenib and Trametinib. ( 27775948 )
2017
38
Subcutaneous panniculitis-like T-cell lymphoma with haemophagocytic syndrome during tocilizumab therapy for juvenile idiopathic arthritis. ( 28079502 )
2017
39
Immunohistochemistry reveals an increased proportion of MYC-positive cells in subcutaneous panniculitis-like T-cell lymphoma compared with lupus panniculitis. ( 28800143 )
2017
40
Exenatide-Induced Panniculitis: Utility of the Acid-Fast Stain to Identify Injected Microspheres. ( 28700374 )
2017
41
Anti-tumour necrosis factor I+-induced lupus erythematosus panniculitis. ( 28045205 )
2017
42
An uncommon cause of panniculitis. ( 29230861 )
2017
43
Panniculitis in the setting of dermato/rheumatologic diseases. ( 29249125 )
2017
44
Successful treatment of hydroxyurea-associated panniculitis and vasculitis with low-dose methotrexate. ( 28932785 )
2017
45
Erythema nodosum-like panniculitis mimicking disease recurrence: A novel toxicity from immune checkpoint blockade therapy. Report of two patients. ( 28901560 )
2017
46
An Unexpected Etiology of Pancreatic Panniculitis: A Case Report. ( 29082362 )
2017
47
Pancreatic Panniculitis. ( 28766564 )
2017
48
Duplex Doppler Sonographic Assessment of the Superior Mesenteric Artery in Patients With Mesenteric Panniculitis. ( 28731594 )
2017
49
Pancreatic acinar cell carcinoma presenting with panniculitis, successfully treated with FOLFIRINOX: A case report. ( 28588779 )
2017
50
Pancreatic Panniculitis and Polyarthritis. ( 28844095 )
2017
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Variations for Panniculitis

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Expression for Panniculitis

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Search GEO for disease gene expression data for Panniculitis.
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Pathways for Panniculitis

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Pathways related to Panniculitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
NF-kappaB Signaling 4
11.68 BTK FAS GZMB IFNG NCAM1 OTULIN
2
IL-2 Signaling Pathway 1
Show member pathways
 11.62 BTK IFNG MYC
3
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.56 MYC NCAM1 SERPINA1
4
Apoptosis and Autophagy 4
11.52 FAS GZMB MYC TIA1
5
Innate Lymphoid Cell Differentiation Pathways 65
11.23 GZMB IFNG NCAM1
6
African trypanosomiasis 37
10.95 FAS IFNG
7
IL-10 Pathway 64
10.91 MYC TIA1
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GO Terms for Panniculitis

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Biological processes related to Panniculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.02 BTK FAS GZMB IFNG TIA1
2 extrinsic apoptotic signaling pathway GO:0097191 8.96 FAS IFNG
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Sources for Panniculitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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