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MCID: PNN001
MIFTS: 52

Panniculitis

Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Panniculitis

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MalaCards integrated aliases for Panniculitis:

Name: Panniculitis 12 73 29 54 44 15 17 70

Classifications:

MalaCards categories:
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:1526
ICD9CM 34 729.30
MeSH 44 D015434
NCIt 50 C112112
SNOMED-CT 67 268122002
ICD10 32 M79.3
UMLS 70 C0030326
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Summaries for Panniculitis

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Disease Ontology : 12 A skin disease that is characterized by inflammation of subcutaneous adipose tissue.

MalaCards based summary : Panniculitis is related to t-cell lymphoma, subcutaneous panniculitis-like and proteasome-associated autoinflammatory syndrome 1, and has symptoms including myalgia, pruritus and exanthema. An important gene associated with Panniculitis is HAVCR2 (Hepatitis A Virus Cellular Receptor 2), and among its related pathways/superpathways are Signaling by GPCR and Innate Immune System. The drugs Doxorubicin and Levoleucovorin have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and pancreas, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Increased viability with MLN4924 (a NAE inhibitor)

Wikipedia : 73 Panniculitis is a group of diseases whose hallmark is inflammation of subcutaneous adipose tissue (the... more...

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Related Diseases for Panniculitis

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Diseases related to Panniculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 673)
# Related Disease Score Top Affiliating Genes
1 t-cell lymphoma, subcutaneous panniculitis-like 33.0 TIA1 HAVCR2 GZMB
2 proteasome-associated autoinflammatory syndrome 1 32.6 PSMB8 PSMB4 IFNG
3 proteasome-associated autoinflammatory syndrome 3 31.9 PSMB9 PSMB4
4 autoimmune lymphoproliferative syndrome 31.2 IL2RA FASLG FAS CD8A
5 exanthem 30.7 IFNG CSF3 CD8A
6 lymphoma, hodgkin, classic 30.6 TIA1 IL2RA GZMB CSF3
7 pancytopenia 30.5 NCAM1 IL2RA IFNG CSF3 CD8A
8 hemophagocytic lymphohistiocytosis 30.5 IL2RA IFNG HAVCR2 GZMB FAS
9 peripheral t-cell lymphoma 30.4 TIA1 NCAM1 GZMB CD8A
10 cutaneous t cell lymphoma 30.4 TIA1 IL2RA IFNG GZMB FAS
11 dermatitis 30.3 PSMB9 IFNG GZMB CD8A
12 lymphoma 30.2 TIA1 MYC IL2RA HAVCR2 GZMB FAS
13 nakajo syndrome 30.2 PSMB8 PSMB4
14 b-cell lymphoma 30.2 TIA1 MYC FAS CASP3 BTK
15 alopecia areata 30.0 IL2RA IFNG GZMB FASLG
16 lymphomatoid granulomatosis 30.0 TIA1 GZMB
17 syphilis 30.0 IFNG FAS CD8A
18 soft tissue sarcoma 30.0 IFNG CSF3
19 autoimmune disease 30.0 PSMB9 IL2RA IFNG HAVCR2 FASLG FAS
20 systemic lupus erythematosus 30.0 PSMB9 PSMB8 IL2RA IFNG HAVCR2 FASLG
21 pulmonary emphysema 30.0 SERPINA1 IFNG CASP3
22 lymphoproliferative syndrome 30.0 TIA1 IL2RA FASLG FAS
23 mature t-cell and nk-cell lymphoma 29.9 TIA1 NCAM1 MYC GZMB CD8A
24 graft-versus-host disease 29.9 IFNG GZMB FASLG FAS
25 polyarticular juvenile idiopathic arthritis 29.9 IFNG BTK
26 chronic graft versus host disease 29.8 IL2RA IFNG
27 hepatitis a 29.8 SERPINA1 IFNG HAVCR2
28 angioimmunoblastic t-cell lymphoma 29.8 TIA1 IL2RA GZMB
29 lichen sclerosus et atrophicus 29.8 TIA1 GZMB CD8A
30 mantle cell lymphoma 29.8 MYC CSF3 CASP3 BTK
31 lymphadenitis 29.7 IL2RA IFNG FASLG FAS CASP3
32 mycosis fungoides 29.7 TIA1 NCAM1 IL2RA IFNG GZMB
33 lymphopenia 29.7 IL2RA IFNG FASLG FAS BTK
34 toxic oil syndrome 29.6 IL2RA IFNG
35 acute graft versus host disease 29.6 IL2RA IFNG FASLG CSF3
36 leukemia, acute lymphoblastic 29.6 NCAM1 MYC CSF3 CD8A CASP3 BTK
37 trypanosomiasis 29.5 IFNG FASLG FAS CSF3
38 viral hepatitis 29.5 SERPINA1 IFNG FASLG FAS
39 hemolytic anemia 29.5 IL2RA IFNG FASLG FAS CSF3
40 leukemia, chronic myeloid 29.5 MYC GZMB CSF3 CASP3 BRAF
41 sjogren syndrome 29.5 IL2RA FASLG FAS
42 peripheral nervous system disease 29.5 NCAM1 MYC IFNG CSF3 CD8A CASP3
43 immune deficiency disease 29.4 IL2RA IFNG FASLG FAS CD8A BTK
44 aplastic anemia 29.4 IL2RA IFNG HAVCR2 FASLG FAS CSF3
45 myeloma, multiple 29.3 NCAM1 MYC CSF3 CD8A CASP3 BTK
46 hashimoto thyroiditis 29.3 IL2RA IFNG FASLG FAS BRAF
47 leukemia, acute myeloid 29.2 NCAM1 MYC HAVCR2 FASLG CSF3 CD8A
48 common variable immunodeficiency 29.2 SERPINA1 IL2RA IFNG GZMB FAS BTK
49 t-cell lymphoblastic leukemia/lymphoma 29.2 MYC IL2RA FASLG FAS CASP3
50 thrombocytopenia 29.2 PSMB9 IFNG HAVCR2 GZMB FASLG FAS

Graphical network of the top 20 diseases related to Panniculitis:



Diseases related to Panniculitis
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Symptoms & Phenotypes for Panniculitis

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UMLS symptoms related to Panniculitis:


myalgia; pruritus; exanthema; decreased adipose tissue; other musculoskeletal symptoms referable to limbs; pain in limb; integumentary system signs and symptoms

GenomeRNAi Phenotypes related to Panniculitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-1 9.97 TIA1
2 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-2 9.97 BRAF BTK CASP3 FAS FASLG GZMB
3 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.97 BRAF
4 Reduced mammosphere formation GR00396-S 9.56 BRAF CSF3 FAS FASLG IL2RA MYC
5 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.47 CASP3 FAS GZMB IL2RA NAV3 PSMB8
6 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.47 CASP3 FAS GZMB IL2RA NAV3 PSMB8

MGI Mouse Phenotypes related to Panniculitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.27 BRAF BTK CASP3 CD8A CSF3 FAS
2 immune system MP:0005387 10.2 BRAF BTK CASP3 CD8A CSF3 FAS
3 cellular MP:0005384 10.17 BRAF BTK CASP3 CD8A FAS FASLG
4 digestive/alimentary MP:0005381 10.01 BRAF BTK CASP3 FAS FASLG IFNG
5 mortality/aging MP:0010768 10 BRAF BTK CASP3 CD8A FAS FASLG
6 integument MP:0010771 9.91 BRAF BTK CASP3 CD8A CSF3 FAS
7 neoplasm MP:0002006 9.56 BRAF BTK FAS FASLG IFNG MYC
8 renal/urinary system MP:0005367 9.23 BRAF CASP3 CD8A CSF3 FAS FASLG
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Drugs & Therapeutics for Panniculitis

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Drugs for Panniculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 4 23214-92-8 31703
2
Levoleucovorin Approved, Investigational Phase 4 68538-85-2 149436
3
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
4
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
5
Pirarubicin Investigational Phase 4 72496-41-4
6 Antirheumatic Agents Phase 4
7 Immunosuppressive Agents Phase 4
8 Alkylating Agents Phase 4
9
Liposomal doxorubicin Phase 4 31703
10 Tubulin Modulators Phase 4
11 Antimitotic Agents Phase 4
12 Antibiotics, Antitubercular Phase 4
13 Hormone Antagonists Phase 4
14 glucocorticoids Phase 4
15 Antineoplastic Agents, Hormonal Phase 4
16 Anti-Bacterial Agents Phase 4
17 Anti-Inflammatory Agents Phase 4
18 Folic Acid Antagonists Phase 4
19 Vitamin B9 Phase 4
20 Folate Phase 4
21 Vitamin B Complex Phase 4
22 Antimetabolites Phase 4
23 Dermatologic Agents Phase 4
24
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
25
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
26
Etoposide Approved Phase 2 33419-42-0 36462
27
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
28
Ifosfamide Approved Phase 2 3778-73-2 3690
29
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
30
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
31
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
32
Gemcitabine Approved Phase 2 95058-81-4 60750
33
Pembrolizumab Approved Phase 2 1374853-91-4
34 10-deazaaminopterin Phase 1, Phase 2
35 Etoposide phosphate Phase 2
36
Isophosphamide mustard Phase 2 100427
37 Immunologic Factors Phase 2
38 Antineoplastic Agents, Immunological Phase 2
39 Immunoglobulins Phase 2
40 Immunoconjugates Phase 2
41 Immunoglobulins, Intravenous Phase 2
42 Antibodies Phase 2
43 Antibodies, Monoclonal Phase 2
44
rituximab Approved Phase 1 174722-31-7 10201696
45
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
46
Vitamin D3 Approved, Nutraceutical 67-97-0 6221 5280795
47 Hormones
48 Micronutrients
49 Trace Elements
50 Nutrients

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 An Open-label,Multicenter Randomised Study of CTOP/ITE/MTX Compared With CHOP as the First-line Therapy for the New Diagnosed Young Patients With T Cell Non-hodgkin Lymphoma Unknown status NCT01746992 Phase 4 Cyclophosphamide 750mg/m2;Vincristine 1.4mg/m2;Doxorubicin 50mg/m2;prednisone 60mg/m2;ifosfamide 2000mg/m2;pirarubicin 50mg/m2;pirarubicin 25mg/m2;Etoposide phosphate 100mg/m2;methotrexate 1500mg/m2
2 A Phase 1/2 Study of Pembrolizumab Plus Pralatrexate for Treatment of Relapsed or Refractory Peripheral T-Cell Lymphomas Recruiting NCT03598998 Phase 1, Phase 2 Pralatrexate
3 CEOP/IVE/GDP Compared With CEOP as the First-line Therapy for Newly Diagnosed Adult Patients With Peripheral T-cell Lymphoma (PTCL) Active, not recruiting NCT02533700 Phase 2 CEOP/IVE/GDP chemotherapy regimen;CEOP chemotherapy regimen for 6 cycles
4 Phase II Study of Brentuximab Vedotin in Combination With Pembrolizumab in Patients With Recurrent Systemic Peripheral T-Cell Lymphoma (PTCL) Not yet recruiting NCT04795869 Phase 2 Brentuximab Vedotin
5 Phase 1 Trial of Siplizumab and Dose-Adjusted EPOCH-Rituximab (DA-EPOCH-R) in T and NK-Cell Lymphomas Active, not recruiting NCT01445535 Phase 1 Etoposide;Prednisone;Vincristine;Cyclophosphamide;Doxorubicin
6 Mesenteric Panniculitis : Review of Consecutive Abdominal MDCT Examinations With a Matched-pair Analysis Completed NCT03316001
7 Prospective Collection of Data in Pts With Peripheral T-Cell Lymphoma: PTCL,NOS;AITL; Extranodal NK/T-cell;Enteropathy-type; Hepatosplenic γ-δ; Subcutaneous Panniculitis-like; ALCL,Primary Systemic Type. By the Intl. T-Cell Lymphoma Project Completed NCT01142674
8 A Pilot Feasibility Trial of the Tolerability of Oral Salvia Hispanica and Its Effect on Blood Fatty Acids and Stool Microbiome in Patients With Treated Non-Hodgkin Lymphoma Completed NCT02652715
9 Cyclophosphamide in the Treatment of Panniculitis Associated Acquired Lipodystrophy Syndrome With Type 1 Diabetes Recruiting NCT03936829 Cyclophosphamide
10 Effect of Vitamin D Replacement on Tumor Response and Survival Parameters for Vitamin D Insufficient Patients With Cancer Recruiting NCT01787409
11 Inflammation and Oxidative Stress of Adipose Tissue in Obese and Non-obese Patients Having Sleep Apnea Syndrome Active, not recruiting NCT01196845
12 Prospective Study of Functional and Quality of Life Outcomes in Panniculectomy Patients Terminated NCT01464658

Search NIH Clinical Center for Panniculitis

Cochrane evidence based reviews: panniculitis

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Genetic Tests for Panniculitis

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Genetic tests related to Panniculitis:

# Genetic test Affiliating Genes
1 Panniculitis 29
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Anatomical Context for Panniculitis

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MalaCards organs/tissues related to Panniculitis:

40
Skin, Breast, Pancreas, Bone, Liver, Kidney, Myeloid
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Publications for Panniculitis

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Articles related to Panniculitis:

(show top 50) (show all 3303)
# Title Authors PMID Year
1
New Findings in PiZZ alpha1-antitrypsin deficiency-related panniculitis. Demonstration of skin polymers and high dosing requirements of intravenous augmentation therapy. 61 54
19218787 2009
2
Alpha1-antitrypsin deficiency: incidence and implications. 61 54
16327507 2005
3
A review of alpha-1 antitrypsin deficiency. 61 54
17136953 2005
4
A review of alpha-1 antitrypsin deficiency. 61 54
16088434 2005
5
Alpha-1-antitrypsin associated panniculitis: the MS variant. 61 54
15389208 2004
6
Nasal-type natural killer cell lymphoma preceded by benign panniculitis arising in an asymptomatic HTLV-1 carrier. 61 54
12956685 2003
7
alpha 1-antitrypsin deficiency-associated panniculitis: resolution with intravenous alpha 1-antitrypsin administration and liver transplantation. 61 54
9039946 1997
8
Clinical characteristics, treatment, and outcome of pancreatitis, panniculitis, and polyarthritis syndrome: a case-based review. 61
32776311 2021
9
Ulcerative versus non-ulcerative panniculitis: is it time for a novel clinical approach to panniculitis? 61
33040341 2021
10
A rare finding from a colonoscopy and laparoscopy of a patient with mesenteric panniculitis mimicking cancerous peritonitis. 61
33189724 2021
11
Panniculitis in a Woman With Opportunistic Pulmonary Coinfection by Pneumocystis jirovecii and Cryptococcus neoformans: 18F-FDG PET/CT Revealing the Infection and Assessing Treatment Response. 61
33315665 2021
12
Unraveling subcutaneous panniculitis-like T-cell lymphoma: An association between subcutaneous panniculitis-like T-cell lymphoma, autoimmune lymphoproliferative syndrome, and familial hemophagocytic lymphohistiocytosis. 61
32894575 2021
13
Dermatologic sequelae of breast cancer: From disease, surgery, and radiation. 61
33226140 2021
14
Panniculitis in a patient with metastatic renal cell carcinoma on a tyrosine kinase inhibitor. 61
33290313 2021
15
A Case Report and Anesthetic Considerations in Subcutaneous Fat Necrosis of the Newborn. 61
33684082 2021
16
Injection Reactions after Administration of Sustained-release Meloxicam to BALB/cJ, C57BL/6J, and Crl:CD1(ICR) Mice. 61
33402233 2021
17
Severe hypercalcemia and acute renal failure in an infant with subcutaneous fat necrosis. 61
33715600 2021
18
Pancreatitis, Panniculitis, and Polyarthritis Syndrome Detected on 99mTc-MDP Bone Scan. 61
33323733 2021
19
Hemophagocytic lymphohistiocytosis associated with primary cutaneous gamma-delta T-cell lymphoma presenting with subcutaneous panniculitis in a 12-year-old girl. 61
33788397 2021
20
Lupus erythematosus: Significance of dermatologic findings. 61
33483145 2021
21
Painless Panniculitis upon the Treatment of Clinically Amyopathic Dermatomyositis with Anti-MDA5 Antibody. 61
33678748 2021
22
A rare case of penetration related to ischemic duodenitis after ventricular assist device implantation for dilated cardiomyopathy. 61
33763820 2021
23
A case of systemic lupus erythematosus with marked ascites due to idiopathic non-cirrhotic portal hypertension. 61
33783333 2021
24
Erythema Nodosum: A Practical Approach and Diagnostic Algorithm. 61
33683567 2021
25
Pancreatitis, panniculitis, and polyarthritis syndrome complicated with terminal pancreatic adenocarcinoma managed with intra-articular knee aspiration, intra-articular lidocaine and corticosteroid injection, and decompression of panniculitis: A case report. 61
33717781 2021
26
Ponatinib-associated panniculitis: Case report and review of the literature. 61
33756173 2021
27
Viral panniculitis in a patient with disseminated opportunistic Enterovirus infection. 61
33277938 2021
28
Treatment considerations in case of subcutaneous panniculitis like T cell lymphoma with hemophagocytic syndrome. 61
33404186 2021
29
Subcutaneous panniculitis-like T-cell lymphoma invading central nervous system in long-term clinical remission with lenalidomide: A case report. 61
33748238 2021
30
A Very Rare Case of Mass-Like Mesenteric Fat Necrosis in a Patient with Antiphospholipid Syndrome. 61
33791401 2021
31
Laparoscopic hybrid pancreaticoduodenectomy: Initial single center experience. 61
33649262 2021
32
Cutaneous Histoplasmosis in HIV Seronegative Patients: A Clinicopathological Analysis. 61
33626536 2021
33
Investigating the presence of neutrophil extracellular traps in septal and lobular cutaneous panniculitides. 61
33580883 2021
34
Hemophagocytic Lymphohistiocytosis Associated with Disseminated Nontuberculous Mycobacterial Infection in a Patient with Mesenteric Panniculitis. 61
33658450 2021
35
Pyogranulomatous panniculitis in a domestic cat associated with Pseudomonas luteola infection. 61
32991013 2021
36
Mesenteric panniculitis and abdominal pain: A casual association? Retrospective case series analysis. 61
33545236 2021
37
Lobular panniculitis associated with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. 61
32840874 2021
38
Subcutaneous Panniculitis-like T-Cell Lymphoma Without Erythema and Subcutaneous Tumors. 61
33642912 2021
39
[Research Progression of Subcutaneous Panniculitis-like T-Cell Lymphoma--Review]. 61
33554838 2021
40
Pancreatic panniculitis in a patient with pancreatic adenosquamous carcinoma. 61
33124679 2021
41
Fatal case of pancreatic panniculitis caused by occult neuroendocrine tumor in the corresponding organ: A case report and review of the published work. 61
33073392 2021
42
Methicillin-resistant Staphylococcus aureus (MRSA) panniculitis in a patient undergoing stem cell mobilisation. 61
33563686 2021
43
Pelvic panniculitis mimicking abscess in a patient with systemic lupus erythematosus. 61
33655318 2021
44
Abatacept-Induced Panniculitis With Necrobiosis Lipoidica-Like Features in a Patient With Rheumatoid Arthritis. 61
33777549 2021
45
A Review of the Dermatological Complications of Giant Cell Arteritis. 61
33790612 2021
46
Cutaneous Coinfection of Cytomegalovirus and Mycobacterium chelonae Accelerated by Immunosuppression. 61
33564484 2021
47
Inflammation and infarction of adipose tissue: implications in bariatric surgery. 61
32969263 2021
48
Lobular panniculitis of the thigh as the only cutaneous manifestation of reactivation of Chagas disease in a renal transplant patient: a case report. 61
33759915 2021
49
Erythema induratum of Bazin in a 10-year-old boy. 61
33006145 2021
50
Intravenous Immune Globulin (IVIG) Therapy After Unsuccessful Treatment with Corticosteroid and Cyclosporine A in Pfeifer-Weber-Christian Disease: A Case Report. 61
33390586 2021
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Variations for Panniculitis

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Expression for Panniculitis

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Search GEO for disease gene expression data for Panniculitis.
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Pathways for Panniculitis

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Pathways related to Panniculitis according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Signaling by GPCR 65
Show member pathways
 14.11 TIA1 PSMB9 PSMB8 PSMB4 OTULIN NCAM1
2
Innate Immune System 65
Show member pathways
 13.79 SERPINA1 PSMB9 PSMB8 PSMB4 NCAM1 MYC
3
PEDF Induced Signaling 63
Show member pathways
 13.65 MYC IL2RA IFNG FASLG FAS CSF3
4
TGF-Beta Pathway 63
Show member pathways
 13.52 PSMB9 PSMB8 PSMB4 MYC IL2RA IFNG
5
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.15 MYC IFNG FASLG FAS CASP3 BTK
6
Cytokine Signaling in Immune system 65
Show member pathways
 13.04 PSMB9 PSMB8 PSMB4 NCAM1 MYC IL2RA
7
PI3K-Akt signaling pathway 36
Show member pathways
 12.95 MYC IL2RA FASLG FAS CSF3 CASP3
8
Pathways in cancer 36
12.81 MYC IL2RA IFNG FASLG FAS CASP3
9
Allograft rejection 36 1
Show member pathways
 12.78 IL2RA IFNG GZMB FASLG FAS CD8A
10
IL-2 Pathway 63
Show member pathways
 12.76 MYC IL2RA IFNG BTK BRAF
11
Measles 36
Show member pathways
 12.76 MYC IL2RA IFNG FASLG FAS CASP3
12
MAPK signaling pathway 36 1
12.73 MYC FASLG FAS CASP3 BRAF
13
Apoptosis Modulation and Signaling 1
Show member pathways
 12.67 MYC GZMB FASLG FAS CASP3
14
Chks in Checkpoint Regulation 63
Show member pathways
 12.63 PSMB9 PSMB8 PSMB4 MYC FASLG FAS
15
4-1BB Pathway 63
Show member pathways
 12.61 IFNG FASLG FAS CASP3 BRAF
16
Immune response Role of DAP12 receptors in NK cells 23
Show member pathways
 12.48 IFNG GZMB FASLG FAS CASP3 BRAF
17
Antigen processing-Cross presentation 65
Show member pathways
 12.42 PSMB9 PSMB8 PSMB4 CD8A BTK
18
WNT Signaling 63
12.39 PSMB9 PSMB8 PSMB4 MYC
19
JAK-STAT signaling pathway 36
Show member pathways
 12.38 MYC IL2RA IFNG CSF3
20
Proteoglycans in cancer 36
12.27 MYC FASLG FAS CASP3 BRAF
21
Dimerization of procaspase-8 65
Show member pathways
 12.26 FASLG FAS CASP3 BTK
22
p53 Signaling 63
Show member pathways
 12.22 PSMB4 FASLG FAS CASP3
23
Apoptosis and survival Caspase cascade 23
Show member pathways
 12.16 GZMB FASLG FAS CASP3
24
Colorectal Cancer Metastasis 63
12.15 MYC IFNG CASP3 BRAF
25
Apoptosis and Autophagy 4
12.15 TIA1 MYC GZMB FASLG FAS CASP3
26
Presenilin-Mediated Signaling 63
12.06 PSMB9 PSMB8 PSMB4 CASP3
27
IL-2 Signaling Pathway 1
Show member pathways
 12.01 MYC IL2RA IFNG BTK
28
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.92 NCAM1 IL2RA IFNG CSF3 CD8A
29
IL12-mediated signaling events 1
Show member pathways
 11.88 IL2RA IFNG GZMB FASLG CD8A
30
NF-kappaB Signaling 4
11.88 PSMB8 OTULIN NCAM1 IL2RA IFNG HAVCR2
31
Hematopoietic cell lineage 36
11.86 IL2RA CSF3 CD8A
32
Nanomaterial induced apoptosis 1
Show member pathways
 11.77 FASLG FAS CASP3
33
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.73 IL2RA IFNG FASLG CASP3
34
Dendritic Cells Developmental Lineage Pathway 64
11.72 NCAM1 IFNG CD8A
35
Platinum drug resistance 36
11.71 FASLG FAS CASP3
36
Innate Lymphoid Cell Differentiation Pathways 64
11.67 NCAM1 IL2RA IFNG GZMB CD8A
37
IL2 signaling events mediated by PI3K 1
Show member pathways
 11.66 MYC IL2RA FASLG
38
Photodynamic therapy-induced AP-1 survival signaling. 1
11.52 IFNG FASLG FAS
39
Hepatitis C and Hepatocellular Carcinoma 1
11.52 MYC FASLG CASP3
40
Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway 1
11.47 MYC IL2RA BTK
41
African trypanosomiasis 36
11.34 IFNG FASLG FAS
42
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.22 IL2RA IFNG GZMB FASLG CD8A BRAF
43
IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
Show member pathways
 11.21 IL2RA IFNG GZMB FASLG FAS
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GO Terms for Panniculitis

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Cellular components related to Panniculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.71 FASLG FAS CASP3 BTK
2 external side of plasma membrane GO:0009897 9.65 NCAM1 IL2RA FASLG FAS CD8A
3 proteasome complex GO:0000502 9.54 PSMB9 PSMB8 PSMB4
4 death-inducing signaling complex GO:0031264 9.32 FAS CASP3
5 spermatoproteasome complex GO:1990111 9.16 PSMB9 PSMB8
6 proteasome core complex GO:0005839 9.13 PSMB9 PSMB8 PSMB4
7 proteasome core complex, beta-subunit complex GO:0019774 8.8 PSMB9 PSMB8 PSMB4

Biological processes related to Panniculitis according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.97 PSMB9 PSMB8 PSMB4 OTULIN GZMB CASP3
2 immune system process GO:0002376 9.95 PSMB9 PSMB8 OTULIN IL2RA HAVCR2 CD8A
3 protein deubiquitination GO:0016579 9.92 PSMB9 PSMB8 PSMB4 MYC
4 immune response GO:0006955 9.91 IL2RA IFNG FASLG FAS CSF3 CD8A
5 cytokine-mediated signaling pathway GO:0019221 9.85 MYC IL2RA FASLG CSF3 CASP3
6 T cell receptor signaling pathway GO:0050852 9.84 PSMB9 PSMB8 PSMB4 BRAF
7 Fc-epsilon receptor signaling pathway GO:0038095 9.83 PSMB9 PSMB8 PSMB4 BTK
8 interleukin-1-mediated signaling pathway GO:0070498 9.81 PSMB9 PSMB8 PSMB4
9 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 9.8 PSMB9 PSMB8 PSMB4
10 Wnt signaling pathway, planar cell polarity pathway GO:0060071 9.79 PSMB9 PSMB8 PSMB4
11 anaphase-promoting complex-dependent catabolic process GO:0031145 9.79 PSMB9 PSMB8 PSMB4
12 regulation of mitotic cell cycle phase transition GO:1901990 9.78 PSMB9 PSMB8 PSMB4
13 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.77 PSMB9 PSMB8 PSMB4
14 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 9.77 PSMB9 PSMB8 PSMB4
15 NIK/NF-kappaB signaling GO:0038061 9.76 PSMB9 PSMB8 PSMB4
16 regulation of hematopoietic stem cell differentiation GO:1902036 9.75 PSMB9 PSMB8 PSMB4
17 negative regulation of G2/M transition of mitotic cell cycle GO:0010972 9.73 PSMB9 PSMB8 PSMB4
18 regulation of cellular amino acid metabolic process GO:0006521 9.69 PSMB9 PSMB8 PSMB4
19 extrinsic apoptotic signaling pathway GO:0097191 9.65 IFNG FASLG FAS
20 apoptotic signaling pathway GO:0097190 9.62 FASLG FAS CASP3 BTK
21 necroptotic signaling pathway GO:0097527 9.57 FASLG FAS
22 proteolysis involved in cellular protein catabolic process GO:0051603 9.56 PSMB9 PSMB8 PSMB4 GZMB
23 apoptotic process GO:0006915 9.56 TIA1 IL2RA IFNG GZMB FASLG FAS
24 activation-induced cell death of T cells GO:0006924 9.55 IL2RA FAS
25 tumor necrosis factor-mediated signaling pathway GO:0033209 9.55 PSMB9 PSMB8 PSMB4 FASLG FAS
26 proteasomal ubiquitin-independent protein catabolic process GO:0010499 9.54 PSMB9 PSMB8 PSMB4
27 MAPK cascade GO:0000165 9.17 PSMB9 PSMB8 PSMB4 NCAM1 MYC IL2RA

Molecular functions related to Panniculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.16 TIA1 SERPINA1 PSMB9 PSMB8 PSMB4 OTULIN
2 endopeptidase activity GO:0004175 9.43 PSMB9 PSMB8 PSMB4
3 peptidase activity GO:0008233 9.43 PSMB9 PSMB8 PSMB4 OTULIN GZMB CASP3
4 threonine-type endopeptidase activity GO:0004298 8.8 PSMB9 PSMB8 PSMB4
Sources

Sources for Panniculitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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