Panniculitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PNN001 MIFTS: 52	Panniculitis Categories: Muscle diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Panniculitis

MalaCards integrated aliases for Panniculitis:

Name: Panniculitis ¹² ⁷⁷ ³⁰ ⁵⁶ ⁴⁵ ¹⁵ ¹⁷ ⁷⁴

Classifications:

MalaCards categories:
Anatomical: Skin diseases Muscle diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Diseases of the musculoskeletal system and connective tissue

Other soft tissue disorders

Other soft tissue disorders, not elsewhere classified

Panniculitis, unspecified

External Ids:

Disease Ontology ¹² DOID:1526

ICD9CM ³⁶ 729.3 729.30

MeSH ⁴⁵ D015434

NCIt ⁵¹ C112112

SNOMED-CT ⁶⁹ 22125009

ICD10 ³⁴ M79.3

EFO ¹⁷ EFO_1000746

UMLS ⁷⁴ C0030326

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Summaries for Panniculitis

MalaCards based summary : Panniculitis is related to subcutaneous panniculitis-like t-cell lymphoma and peripheral t-cell lymphoma, and has symptoms including pruritus, myalgia and exanthema. An important gene associated with Panniculitis is OTULIN (OTU Deubiquitinase With Linear Linkage Specificity), and among its related pathways/superpathways are Signaling by GPCR and Antigen processing-Cross presentation. The drugs Vincristine and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and neutrophil, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : ⁷⁷ Panniculitis is a group of diseases whose hallmark is inflammation of subcutaneous adipose tissue (the... more...

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Related Diseases for Panniculitis

Diseases related to Panniculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 334)

#	Related Disease	Score	Top Affiliating Genes
1	subcutaneous panniculitis-like t-cell lymphoma	33.6	GZMB NAV3 NCAM1 TIA1
2	peripheral t-cell lymphoma	29.8	GZMB NCAM1 TIA1
3	b-cell lymphomas	29.7	BTK FAS TIA1
4	cutaneous t cell lymphoma	29.6	GZMB IFNG TIA1
5	hemophagocytic lymphohistiocytosis	29.6	FAS GZMB IFNG
6	graft-versus-host disease	28.9	FAS GZMB IFNG
7	nodular nonsuppurative panniculitis	12.8
8	lupus erythematosus panniculitis	12.5
9	autoinflammation, panniculitis, and dermatosis syndrome	12.4
10	cytophagic histiocytic panniculitis	12.3
11	infantile onset panniculitis with uveitis and systemic granulomatosis	12.1
12	panniculitis-induced localized lipodystrophy	12.0
13	localized lipodystrophy	11.9
14	lipodermatosclerosis	11.9
15	proteasome-associated autoinflammatory syndrome 1	11.8
16	alpha-1-antitrypsin deficiency	11.6
17	igg4-related mesenteritis	11.6
18	peritonitis	11.5
19	acquired generalized lipodystrophy	11.3
20	proteasome-associated autoinflammatory syndrome 3	11.2
21	autoimmune lymphoproliferative syndrome	11.0
22	erythema nodosum, idiopathic	11.0
23	lymphoma	10.8
24	lupus erythematosus	10.6
25	pancreatitis	10.5
26	dermatomyositis	10.4
27	systemic lupus erythematosus	10.3
28	vasculitis	10.3
29	lichen sclerosus et atrophicus	10.3	GZMB TIA1
30	lymphomatoid granulomatosis	10.3	GZMB TIA1
31	viral esophagitis	10.3	GZMB TIA1
32	primary cutaneous anaplastic large cell lymphoma	10.3	GZMB TIA1
33	fasciitis	10.3
34	composite lymphoma	10.3	GZMB TIA1
35	hepatosplenic t-cell lymphoma	10.3	GZMB TIA1
36	arthritis	10.3
37	choriocarcinoma of the testis	10.3	GZMB TIA1
38	giardiasis	10.3	GZMB TIA1
39	lethal midline granuloma	10.3	NCAM1 TIA1
40	dermatitis	10.3
41	infiltrating lipoma	10.2	GZMB TIA1
42	necrotizing sialometaplasia	10.2	GZMB TIA1
43	cardiac sarcoidosis	10.2	PSMB8 PSMB9
44	rhinoscleroma	10.2	NCAM1 SERPINA1
45	t-cell large granular lymphocyte leukemia	10.2	GZMB NCAM1
46	angioimmunoblastic t-cell lymphoma	10.2	GZMB TIA1
47	multiple sclerosis	10.2
48	alopecia	10.2
49	acinar cell carcinoma	10.2
50	cystadenofibroma	10.2	NCAM1 SERPINA1

Graphical network of the top 20 diseases related to Panniculitis:

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Symptoms & Phenotypes for Panniculitis

UMLS symptoms related to Panniculitis:

pruritus, myalgia, exanthema, decreased adipose tissue, other musculoskeletal symptoms referable to limbs, pain in limb, integumentary system signs and symptoms

GenomeRNAi Phenotypes related to Panniculitis according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-1	9.72	FAS GZMB NAV3 PSMB8 PSMB9 TIA1
2	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-2	9.72	FAS GZMB NAV3 PSMB8 PSMB9 TIA1

MGI Mouse Phenotypes related to Panniculitis:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.5	BTK FAS IFNG OTULIN PSMB8 PSMB9
2	neoplasm	MP:0002006	9.02	BTK FAS IFNG PSMB8 PSMB9

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Drugs & Therapeutics for Panniculitis

Drugs for Panniculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 89)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Vincristine

Approved, Investigational

Phase 4

2068-78-2, 57-22-7

5978

Ifosfamide

Approved

Phase 4

3778-73-2

3690

Prednisone

Approved, Vet_approved

Phase 4

53-03-2

5865

Epirubicin

Approved

Phase 4

56420-45-2

41867

Cyclophosphamide

Approved, Investigational

Phase 4

6055-19-2, 50-18-0

2907

Cisplatin

Approved

Phase 4

15663-27-1

441203 84093 2767

Etoposide

Approved

Phase 4

33419-42-0

36462

Gemcitabine

Approved

Phase 4,Phase 1,Phase 2

95058-81-4

60750

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 4

1177-87-3

Dexamethasone

Approved, Investigational, Vet_approved

Phase 4

50-02-2

5743

Methyltestosterone

Approved

Phase 4

58-18-4

6010

Testosterone undecanoate

Approved, Investigational

Phase 4

5949-44-0

Testosterone

Approved, Experimental, Investigational

Phase 4

58-22-0, 481-30-1

6013 10204

Testosterone enanthate

Approved

Phase 4

315-37-7

9416

leucovorin

Approved

Phase 4,Phase 1,Phase 2

58-05-9

6006 143

Methotrexate

Approved

Phase 4

1959-05-2, 59-05-2

126941

Mechlorethamine

Approved, Investigational

Phase 4

51-75-2

4033

Doxorubicin

Approved, Investigational

Phase 4

23214-92-8

31703

Folic Acid

Approved, Nutraceutical, Vet_approved

Phase 4,Phase 1,Phase 2

59-30-3

6037

Pirarubicin

Investigational

Phase 4

72496-41-4

Doxil

Approved June 1999

Phase 4

31703

Isophosphamide mustard

Phase 4

Anti-Bacterial Agents

Phase 4,Phase 1

Anti-Inflammatory Agents

Phase 4

Antineoplastic Agents, Alkylating

Phase 4

Etoposide phosphate

Phase 4

Hormones

Phase 4,Phase 2,Not Applicable

BB 1101

Phase 4

Immunosuppressive Agents

Phase 4,Phase 1,Phase 2

Antineoplastic Agents, Hormonal

Phase 4

Hormone Antagonists

Phase 4

Immunologic Factors

Phase 4,Phase 1,Phase 2

Topoisomerase Inhibitors

Phase 4

Alkylating Agents

Phase 4

Antibiotics, Antitubercular

Phase 4,Phase 1

Antimitotic Agents

Phase 4

Antineoplastic Agents, Phytogenic

Phase 4

Antirheumatic Agents

Phase 4,Phase 1

glucocorticoids

Phase 4

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4

Testosterone 17 beta-cypionate

Phase 4

insulin

Phase 4

Anabolic Agents

Phase 4

Insulin, Globin Zinc

Phase 4

Androgens

Phase 4

Vitamin B Complex

Phase 4,Phase 1,Phase 2

Antimetabolites

Phase 4,Phase 1,Phase 2

Antimetabolites, Antineoplastic

Phase 4,Phase 1,Phase 2

Vitamin B9

Phase 4,Phase 1,Phase 2

Folate

Phase 4,Phase 1,Phase 2

Interventional clinical trials:

(show all 22)

#	Name	Status	NCT ID	Phase	Drugs
1	CEOP/IVE/GDP Compared With CEOP as the First-line Therapy for Newly Diagnosed Adult Patients With PTCL	Unknown status	NCT02533700	Phase 4	CEOP/IVE/GDP chemotherapy regimen;CEOP chemotherapy regimen for 6 cycles
2	Testosterone Replacement in Metabolic Syndrome and Inflammation	Completed	NCT01123278	Phase 4	Testosterone;Placebo
3	CTOP/ITE/MTX Compared With CHOP as the First-line Therapy for Newly Diagnosed Young Patients With T Cell Lymphoma	Active, not recruiting	NCT01746992	Phase 4	Cyclophosphamide 750mg/m2;Vincristine 1.4mg/m2;Doxorubicin 50mg/m2;prednisone 60mg/m2;ifosfamide 2000mg/m2;pirarubicin 50mg/m2;pirarubicin 25mg/m2;Etoposide phosphate 100mg/m2;methotrexate 1500mg/m2
4	Effectiveness and Safety of Autologous ADRC for Treatment of Degenerative Damage of Knee Articular Cartilage	Completed	NCT02219113	Phase 1, Phase 2
5	Study of Pralatrexate & Gemcitabine With B12 & Folic Acid to Treat Relapsed/Refractory Lymphoproliferative Malignancies	Completed	NCT00481871	Phase 1, Phase 2	Pralatrexate Injection;Gemcitabine Hydrochloride
6	A Phase II Study to Evaluate Safety and Efficacy of ALX-0061 in Subjects With Systemic Lupus Erythematosus	Completed	NCT02437890	Phase 2
7	Effectiveness and Safety of Autologous ADRC for Treatment of Anterior Cruciate Ligament Partial Rupture	Enrolling by invitation	NCT02469792	Phase 1, Phase 2
8	Autologous Stromal Vascular Fraction of Cells for Treatment of Knee Articular Cartilage Dystrophy	Enrolling by invitation	NCT02827851	Phase 2
9	Vitamin D Status, Disease Specific and Quality of Life Outcomes in Patients With Cutaneous Lupus	Terminated	NCT01498406	Phase 2
10	Phase 1 Trial of Siplizumab and Dose-Adjusted EPOCH-Rituximab in T- and NK-Cell Lymphomas	Active, not recruiting	NCT01445535	Phase 1	EPOCH
11	Everolimus and Bortezomib in Treating Patients With Relapsed or Refractory Lymphoma	Terminated	NCT00671112	Phase 1	Bortezomib;Everolimus
12	Inflammation and Oxidative Stress of Adipose Tissue in Sleep Apnea Syndrome	Unknown status	NCT01196845	Not Applicable
13	Mesenteric Panniculitis : Review of Consecutive Abdominal MDCT Examinations With a Matched-pair Analysis	Completed	NCT03316001
14	Characterization of Transient Alterations of Cutaneous Sensory Nerve Function by Cryolipolysis	Completed	NCT01673113	Not Applicable
15	Diet Induced Weight Loss to Reduce Inflammation in Obese Women	Completed	NCT01699906	Not Applicable
16	GENETIC SUSCEPTIBILITY FACTOR AS A PREDICTOR OF TYPE 2 DIABETES REMISSION AND WEIGHT LOSS AFTER BARIATRIC SURGERY	Completed	NCT02405949
17	T-Cell Project: Prospective Collection of Data in Patients With Peripheral T-Cell Lymphoma	Recruiting	NCT01142674
18	Leipzig Adipose Tissue Childhood Cohort	Recruiting	NCT02208141
19	Cholecalciferol in Improving Survival in Patients With Newly Diagnosed Cancer With Vitamin D Insufficiency	Recruiting	NCT01787409	Not Applicable
20	Study of the Efficacy of 532nm Laser and 1064 nm Laser in the Treatment of Cutaneous Lupus Erythematous Versus Topical Corticosteroids Alone	Recruiting	NCT03639857	Not Applicable	Topical corticosteroid
21	Salvia Hispanica Seed in Reducing Risk of Disease Recurrence in Patients With Non-Hodgkin Lymphoma	Active, not recruiting	NCT02652715	Not Applicable
22	Prospective Study of Functional and Quality of Life Outcomes in Panniculectomy Patients	Terminated	NCT01464658	Not Applicable

Search NIH Clinical Center for Panniculitis

Cochrane evidence based reviews: panniculitis

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Genetic Tests for Panniculitis

Genetic tests related to Panniculitis:

#	Genetic test	Affiliating Genes
1	Panniculitis ³⁰

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Anatomical Context for Panniculitis

MalaCards organs/tissues related to Panniculitis:

⁴²

T Cells, Skin, Neutrophil, Breast, Pancreas, Bone, Liver

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Publications for Panniculitis

Articles related to Panniculitis:

(show top 50) (show all 1583)

#	Title	Authors	Year
1	Polymyositis with antisynthetase syndrome presented with lobular panniculitis: A case report. ( 30656025 )	Rungcharunthanakul A...Sampattavanich N	2019
2	Sterile Pyogranulomatous Dermatitis and Panniculitis. ( 30390792 )	Schissler J	2019
3	Hematopoietic stem cell transplantation for subcutaneous panniculitis-like T-cell lymphoma: single center experience in an Asian population. ( 30547418 )	Lin TA...Gau JP	2019
4	Histoplasma panniculitis in a patient with systemic lupus erythematosus. ( 30726473 )	Flores-Bozo LR...Soto-Ram?rez LE	2019
5	Panniculitis in childhood-onset systemic lupus erythematosus: a multicentric cohort study. ( 30658703 )	Verdier M...Silva CA	2019
6	Subcutaneous Panniculitis-Like T-Cell Lymphoma With Granulomas as the Predominant Feature. ( 30908292 )	Lee C...Lazova R	2019
7	Successful treatment of a rare subcutaneous panniculitis-like T-cell lymphoma: An unusual case report and literature review. ( 30884048 )	Xu L...Sun X	2019
8	Frequent germline mutations of HAVCR2 in sporadic subcutaneous panniculitis-like T-cell lymphoma. ( 30792187 )	Polprasert C...Makishima H	2019
9	Treatment of Facial Lipoatrophy Secondary to Subcutaneous Panniculitis-Like T-Cell Lymphoma. ( 30829756 )	Yan BY...Rossi AM	2019
10	Pediatric Subcutaneous Panniculitis-like T-Cell Lymphoma With Hemophagocytosis Showing Complete Resolution With the BFM90 Protocol: Case Report and Review of Literature. ( 30730380 )	Singh S...John MJ	2019
11	Cytophagic Histiocytic Panniculitis Associated with Myelodysplastic Syndrome. ( 30226527 )	Kimura R...Yamamoto O	2019
12	Pancreatitis panniculitis polyarthritis syndrome with multiple bone infarcts. ( 30351366 )	Agarwal S...Vikram N	2019
13	The mesenteric panniculitis: a truly idiopathic disease? ( 30759974 )	Buragina G...Magenta Biasina A	2019
14	Vemurafenib-induced histiocytoid neutrophilic panniculitis simulating myeloid leukaemia cutis. ( 30426827 )	Richarz NA...Fern?ndez-Figueras MT	2019
15	Equestrian cold panniculitis in a cold-storage-room worker. ( 30628122 )	Adachi A...Akiyama M	2019
16	Familial lupus panniculitis: two cases, same diagnosis, what evolution? ( 30636398 )	Molinelli E...Offidani A	2019
17	Post-erysipela panniculitis ossificans of the lower leg treated with pentoxifylline. ( 30638288 )	Michelerio A...Vassallo C	2019
18	Mesenteric panniculitis: comparison of computed tomography findings in patients with and without malignancy. ( 30643446 )	Al-Omari MH...Elheis M	2019
19	A case of erythema nodosum-like panniculitis induced by nivolumab in a patient with oesophageal cancer. ( 30656640 )	Choi ME...Lee WJ	2019
20	Neutrophilic Panniculitis in a child with MYSM1 deficiency. ( 30746751 )	Nanda A...Adekile AD	2019
21	Livedo Racemosa, Reticulated Ulcerations, Panniculitis and Violaceous Plaques in a 46-year-old Woman. ( 29441299 )	AgullA^ A....Yanguas I.	2018
22	Septolobular panniculitis in disseminated Lyme borreliosis. ( 29293267 )	Dittmer M.R....Liu V.	2018
23	Pancreatic panniculitis: the &quot;bright&quot; side of the moon in solid cancer patients. ( 29301491 )	Guanziroli E....Marzano A.V.	2018
24	Inherited Immunodeficiency: A New Association With Early-Onset Childhood Panniculitis. ( 29610179 )	Bader-Meunier B....Bodemer C.	2018
25	Panniculitis associated with amyopathic dermatomyositis. ( 29641712 )	Azevedo P.O....Pinto C.A.L.	2018
26	Composite cutaneous lymphoma of diffuse large B-cell lymphoma-leg type and subcutaneous panniculitis-like T-cell lymphoma. ( 29851123 )	Szablewski V....Joujoux J.M.	2018
27	Analysis of Bacterial and Fungal Nucleic Acid in Canine Sterile Granulomatous and Pyogranulomatous Dermatitis and Panniculitis. ( 29145794 )	Rosa F.B....Hoffmann A.R.	2018
28	Diffuse granulomatous panniculitis associated with anti PD-1 antibody therapy. ( 29296642 )	Jiang B....Kim K.B.	2018
29	Ultrasound of pancreatic panniculitis. ( 29736975 )	Martinez-Mera C....Roustan GullA^n G.	2018
30	Spontaneous Resolution of Idiopathic Panniculitis: Role of <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Diagnosis and follow-up. ( 29962727 )	Verma P....Asopa R.V.	2018
31	Alpha-1 antitrypsin deficiency panniculitis: clinical and pathologic characteristics of 10 cases. ( 29707779 )	Johnson E.F....Gibson L.E.	2018
32	Subcutaneous Panniculitis-Like T-Cell Lymphoma Versus Lupus Erythematosus Panniculitis: Distinction by Means of the Periadipocytic Cell Proliferation Index. ( 29742552 )	Sitthinamsuwan P....McCalmont T.H.	2018
33	Recurrent lupus profundus-like panniculitis associated with streptococcal throat infections in an immunocompetent child. ( 29693070 )	Min M.S....Levitt J.	2018
34	Lupus erythematosus panniculitis in a 10-year-old female child with severe systemic lupus erythematosus: A case report. ( 29504978 )	Zhang R....Yi Z.	2018
35	Cold Panniculitis After Ice Therapy for Supraventricular Tachycardia. ( 29698337 )	Malia L....Laurich V.M.	2018
36	Pancreatic panniculitis: A case series from a tertiary university hospital in Spain. ( 29741276 )	FernA!ndez-Sartorio C....MascarA^ J.M.	2018
37	Mesenteric Panniculitis Presenting as Fever of Unknown Etiology in a Patient with History of Abdominal Surgery. ( 29670775 )	Irwin C.P....Mount G.	2018
38	A Case of Refractory Subcutaneous Panniculitis-like T-cell Lymphoma with Bone Marrow and Lung Involvement Treated Successfully with Oral Etoposide. ( 29881869 )	Saito A....Fujimoto M.	2018
39	Chronic pancreatitis with multiple pseudocysts and pancreatic panniculitis: A case report. ( 29851820 )	Gu Y....Qian Z.	2018
40	Intravascular large B-cell lymphoma presenting as panniculitis clinically: a case report. ( 29568849 )	Phoon Y.W....Lee H.Y.	2018
41	Pancreatic panniculitis as a presentation symptom of acinar cell carcinoma. ( 29527901 )	de Frutos Rosa D....Guirado Koch C.	2018
42	Cold panniculitis: Adverse cutaneous effect of whole-body cryotherapy. ( 29693065 )	Greenwald E....Liebman T.N.	2018
43	Breast panniculitis with liquefactive fat necrosis: A case report. ( 29904432 )	Zhang Y....Lu Y.	2018
44	An Autopsy Case of Mesenteric Panniculitis with Massive Pleural Effusions. ( 29298971 )	Kobayashi H....Suzuki T.	2018
45	Geometric alopecia associated with lupus erythematosus panniculitis of the scalp: a case series of nine Korean patients. ( 29619994 )	Park S.K....Park J.	2018
46	Mesenteric Panniculitis-First Case Series After Bariatric Surgery. ( 29313276 )	Nasta A.M....Goel R.	2018
47	Evaluation of mesenteric panniculitis with computed tomography: benign condition or paraneoplastic syndrome? ( 29914254 )	KA1peli A....DanA+A9an G.	2018
48	The coexistence of lupus erythematosus panniculitis and subcutaneous panniculitis-like T-cell lymphoma in the same patient. ( 29892661 )	Wu X....Ko C.	2018
49	A case of deadly panniculitis. ( 29970609 )	Yuson C....Hissaria P.	2018
50	Panniculitis Due to Atypical Mycobacteria After Mesotherapy. ( 29859618 )	GarcA-a-Harana C....de Troya-MartA-n M.	2018

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Genes for Panniculitis

Genes related to Panniculitis (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	OTULIN	OTU Deubiquitinase With Linear Linkage Specificity	Protein Coding	33.09	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Variants (show sections)
2	TIA1	TIA1 Cytotoxic Granule Associated RNA Binding Protein	Protein Coding	31.94	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	12956685
3	SERPINA1	Serpin Family A Member 1	Protein Coding	31.7	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	15389208 9039946 19218787 (more) 16327507 16088434 17136953
4	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	23.36	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	GZMB	Granzyme B	Protein Coding	23.34	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	PSMB8	Proteasome Subunit Beta 8	Protein Coding	21.71	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	NAV3	Neuron Navigator 3	Protein Coding	20.64	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	IFNG	Interferon Gamma	Protein Coding	20.18	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	FAS	Fas Cell Surface Death Receptor	Protein Coding	19.93	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	BTK	Bruton Tyrosine Kinase	Protein Coding	19.62	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	PSMB9	Proteasome Subunit Beta 9	Protein Coding	17.42	GeneCards inferred via : Disorders (show sections)

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Variations for Panniculitis

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Expression for Panniculitis

Search GEO for disease gene expression data for Panniculitis.

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Pathways for Panniculitis

Pathways related to Panniculitis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Signaling by GPCR ⁶⁷ Show member pathways GPCR downstream signaling ⁶⁷ Signal Transduction ⁶⁷	13.7	BTK FAS GZMB NCAM1 OTULIN PSMB8
2	Antigen processing-Cross presentation ⁶⁷ Show member pathways Cross-presentation of particulate exogenous antigens (phagosomes) ⁶⁷ Endosomal/Vacuolar pathway ⁶⁷ ER-Phagosome pathway ⁶⁷ Immune response Antigen presentation by MHC class I ²³	12.06	BTK PSMB8 PSMB9
3	Apoptosis and Autophagy ⁴	11.7	FAS GZMB TIA1
4	NF-kappaB Signaling ⁴	11.68	BTK FAS GZMB IFNG NCAM1 OTULIN
5	Apoptosis and survival Caspase cascade ²³ Show member pathways Apoptosis and survival FAS signaling cascades ²³ Breakdown of the nuclear lamina ⁶⁷ Caspase cascade in apoptosis ¹ Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation ¹ FasL/ CD95L signaling ⁶⁷ Influenza A virus infection ¹	11.52	FAS GZMB PSMB8 PSMB9
6	Innate Lymphoid Cell Differentiation Pathways ⁶⁶	11.23	GZMB IFNG NCAM1
7	Type II interferon signaling (IFNG) ¹	10.94	IFNG PSMB9
8	African trypanosomiasis ³⁸	10.89	FAS IFNG

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GO Terms for Panniculitis

Cellular components related to Panniculitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:0005829	9.86	BTK FAS GZMB NCAM1 OTULIN PSMB8
2	proteasome core complex	GO:0005839	9.16	PSMB8 PSMB9
3	proteasome core complex, beta-subunit complex	GO:0019774	8.96	PSMB8 PSMB9
4	spermatoproteasome complex	GO:1990111	8.62	PSMB8 PSMB9

Biological processes related to Panniculitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	proteolysis	GO:0006508	9.67	GZMB OTULIN PSMB8 PSMB9
2	immune system process	GO:0002376	9.46	BTK OTULIN PSMB8 PSMB9
3	extrinsic apoptotic signaling pathway	GO:0097191	9.32	FAS IFNG
4	proteasomal protein catabolic process	GO:0010498	9.26	PSMB8 PSMB9
5	apoptotic process	GO:0006915	9.02	BTK FAS GZMB IFNG TIA1
6	proteasomal ubiquitin-independent protein catabolic process	GO:0010499	8.96	PSMB8 PSMB9

Molecular functions related to Panniculitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	peptidase activity	GO:0008233	9.26	GZMB OTULIN PSMB8 PSMB9
2	threonine-type endopeptidase activity	GO:0004298	8.62	PSMB8 PSMB9

Sources

Sources for Panniculitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

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⁶⁶ R&D Systems

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⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

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⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia