Aliases & Classifications for Panniculitis

MalaCards integrated aliases for Panniculitis:

Name: Panniculitis 12 74 29 54 44 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1526
ICD9CM 34 729.30
MeSH 44 D015434
NCIt 50 C112112
SNOMED-CT 67 268122002
ICD10 32 M79.3
UMLS 71 C0030326

Summaries for Panniculitis

Disease Ontology : 12 A skin disease that is characterized by inflammation of subcutaneous adipose tissue.

MalaCards based summary : Panniculitis is related to t-cell lymphoma, subcutaneous panniculitis-like and proteasome-associated autoinflammatory syndrome 1, and has symptoms including myalgia, pruritus and exanthema. An important gene associated with Panniculitis is HAVCR2 (Hepatitis A Virus Cellular Receptor 2), and among its related pathways/superpathways are Signaling by GPCR and Innate Immune System. The drugs Doxorubicin and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and pancreas, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Increased viability with MLN4924 (a NAE inhibitor)

Wikipedia : 74 Panniculitis is a group of diseases whose hallmark is inflammation of subcutaneous adipose tissue (the... more...

Related Diseases for Panniculitis

Diseases related to Panniculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 650)
# Related Disease Score Top Affiliating Genes
1 t-cell lymphoma, subcutaneous panniculitis-like 32.9 TRG TIA1 HAVCR2 GZMB
2 proteasome-associated autoinflammatory syndrome 1 32.5 PSMB8 PSMB4 IFNG
3 cytophagic histiocytic panniculitis 32.5 TRG CSF3
4 proteasome-associated autoinflammatory syndrome 3 31.9 PSMB9 PSMB4
5 pancytopenia 30.8 NCAM1 IL2RA IFNG CSF3
6 lymphoma, hodgkin, classic 30.6 TIA1 IL2RA GZMB CSF3
7 hemophagocytic lymphohistiocytosis 30.4 IL2RA IFNG HAVCR2 GZMB FAS
8 anaplastic large cell lymphoma 30.4 TIA1 IL2RA GZMB
9 lymphoma 30.4 TIA1 MYC HAVCR2 GZMB FAS CSF3
10 cutaneous t cell lymphoma 30.3 TIA1 IL2RA IFNG GZMB FAS
11 mature t-cell and nk-cell lymphoma 30.2 TIA1 NCAM1 MYC GZMB
12 nakajo syndrome 30.2 PSMB8 PSMB4
13 b-cell lymphoma 30.1 TIA1 MYC FAS CASP3 BTK
14 lymphomatoid granulomatosis 30.0 TIA1 GZMB
15 soft tissue sarcoma 30.0 IFNG CSF3
16 lichen sclerosus et atrophicus 30.0 TIA1 GZMB
17 alopecia areata 30.0 IL2RA IFNG GZMB FASLG
18 pulmonary emphysema 30.0 SERPINA1 IFNG CASP3
19 lymphoproliferative syndrome 29.9 TIA1 IL2RA FASLG FAS
20 autoimmune disease 29.9 PSMB9 IL2RA IFNG HAVCR2 FASLG FAS
21 polyarticular juvenile idiopathic arthritis 29.9 IFNG BTK
22 systemic lupus erythematosus 29.9 PSMB9 PSMB8 IL2RA IFNG HAVCR2 FASLG
23 graft-versus-host disease 29.9 IFNG GZMB FASLG FAS
24 pediatric lymphoma 29.9 TIA1 NCAM1 MYC
25 hepatitis a 29.8 SERPINA1 IFNG HAVCR2
26 angioimmunoblastic t-cell lymphoma 29.8 TIA1 IL2RA GZMB
27 chronic graft versus host disease 29.8 IL2RA IFNG
28 mantle cell lymphoma 29.8 MYC CSF3 CASP3 BTK
29 peripheral nervous system disease 29.7 NCAM1 MYC IFNG CSF3 CASP3
30 leukemia, acute lymphoblastic 29.7 TRG MYC CSF3 CASP3 BTK
31 immune deficiency disease 29.7 IL2RA IFNG FASLG FAS BTK
32 toxic oil syndrome 29.6 IL2RA IFNG
33 lymphadenitis 29.6 IL2RA IFNG FASLG FAS CASP3
34 lymphopenia 29.6 IL2RA IFNG FASLG FAS BTK
35 mycosis fungoides 29.6 TRG TIA1 NCAM1 IL2RA IFNG GZMB
36 acute graft versus host disease 29.5 IL2RA IFNG FASLG CSF3
37 myeloma, multiple 29.5 NCAM1 MYC CSF3 CASP3 BTK BRAF
38 viral hepatitis 29.5 SERPINA1 IFNG FASLG FAS
39 trypanosomiasis 29.5 IFNG FASLG FAS CSF3
40 leukemia, acute myeloid 29.5 NCAM1 MYC HAVCR2 FASLG CSF3 CASP3
41 leukemia, chronic myeloid 29.4 MYC GZMB CSF3 CASP3 BRAF
42 sjogren syndrome 29.4 IL2RA FASLG FAS
43 aplastic anemia 29.4 IL2RA IFNG HAVCR2 FASLG FAS CSF3
44 celiac disease 1 29.3 TIA1 SERPINA1 NCAM1 IL2RA IFNG GZMB
45 lymphoma, non-hodgkin, familial 29.3 NCAM1 MYC IL2RA GZMB FAS CSF3
46 myelodysplastic syndrome 29.2 MYC IFNG HAVCR2 GZMB FASLG FAS
47 thrombocytopenia 29.2 IFNG HAVCR2 GZMB FASLG FAS CSF3
48 common variable immunodeficiency 29.2 SERPINA1 IL2RA IFNG GZMB FAS BTK
49 hashimoto thyroiditis 29.2 IL2RA IFNG FASLG FAS BRAF
50 sezary's disease 29.1 TIA1 NCAM1 NAV3 MYC IL2RA IFNG

Graphical network of the top 20 diseases related to Panniculitis:



Diseases related to Panniculitis

Symptoms & Phenotypes for Panniculitis

UMLS symptoms related to Panniculitis:


myalgia, pruritus, exanthema, decreased adipose tissue, other musculoskeletal symptoms referable to limbs, pain in limb, integumentary system signs and symptoms

GenomeRNAi Phenotypes related to Panniculitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-1 9.97 TIA1
2 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-2 9.97 BRAF BTK CASP3 FAS FASLG GZMB
3 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.97 BRAF
4 Reduced mammosphere formation GR00396-S 9.56 BRAF CSF3 FAS FASLG IL2RA MYC
5 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.47 CASP3 FAS GZMB IL2RA NAV3 PSMB8
6 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.47 CASP3 FAS GZMB IL2RA NAV3 PSMB8

MGI Mouse Phenotypes related to Panniculitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.13 BRAF BTK CASP3 CSF3 FAS FASLG
2 immune system MP:0005387 10 BRAF BTK CASP3 CSF3 FAS FASLG
3 digestive/alimentary MP:0005381 9.92 BRAF BTK CASP3 FAS FASLG IFNG
4 mortality/aging MP:0010768 9.77 BRAF BTK CASP3 FAS FASLG HAVCR2
5 neoplasm MP:0002006 9.23 BRAF BTK FAS FASLG IFNG MYC

Drugs & Therapeutics for Panniculitis

Drugs for Panniculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 4 23214-92-8 31703
2
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
3
Pirarubicin Investigational Phase 4 72496-41-4
4 Immunosuppressive Agents Phase 4
5 Immunologic Factors Phase 4
6 Antirheumatic Agents Phase 4
7 Alkylating Agents Phase 4
8 Antibiotics, Antitubercular Phase 4
9 Anti-Inflammatory Agents Phase 4
10 Hormone Antagonists Phase 4
11 Antimitotic Agents Phase 4
12 Antineoplastic Agents, Hormonal Phase 4
13 Tubulin Modulators Phase 4
14 glucocorticoids Phase 4
15
Liposomal doxorubicin Phase 4 31703
16 Anti-Bacterial Agents Phase 4
17 Antimetabolites Phase 4
18 Dermatologic Agents Phase 4
19
Levoleucovorin Approved, Investigational Phase 1, Phase 2 68538-85-2 149436
20
Pembrolizumab Approved Phase 1, Phase 2 1374853-91-4
21
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
22
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
23
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
24
Etoposide Approved Phase 2 33419-42-0 36462
25
Ifosfamide Approved Phase 2 3778-73-2 3690
26
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
27
Gemcitabine Approved Phase 2 95058-81-4 60750
28
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
29
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
30
Folic acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
31 Antineoplastic Agents, Immunological Phase 1, Phase 2
32 Folic Acid Antagonists Phase 1, Phase 2
33 Vitamin B Complex Phase 1, Phase 2
34 Vitamin B9 Phase 1, Phase 2
35 Folate Phase 1, Phase 2
36 10-deazaaminopterin Phase 1, Phase 2
37 Etoposide phosphate Phase 2
38
Isophosphamide mustard Phase 2 100427
39
rituximab Approved Phase 1 174722-31-7 10201696
40
Vitamin D3 Approved, Nutraceutical 67-97-0 6221 5280795
41
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
42 Hormones
43 Nutrients
44 Micronutrients
45 Trace Elements
46 Vitamins
47 Calcium, Dietary
48 Calciferol
49 Trientine
50
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 An Open-label,Multicenter Randomised Study of CTOP/ITE/MTX Compared With CHOP as the First-line Therapy for the New Diagnosed Young Patients With T Cell Non-hodgkin Lymphoma Unknown status NCT01746992 Phase 4 Cyclophosphamide 750mg/m2;Vincristine 1.4mg/m2;Doxorubicin 50mg/m2;prednisone 60mg/m2;ifosfamide 2000mg/m2;pirarubicin 50mg/m2;pirarubicin 25mg/m2;Etoposide phosphate 100mg/m2;methotrexate 1500mg/m2
2 A Phase 1/2 Study of Pembrolizumab Plus Pralatrexate for Treatment of Relapsed or Refractory Peripheral T-Cell Lymphomas Recruiting NCT03598998 Phase 1, Phase 2 Pralatrexate
3 CEOP/IVE/GDP Compared With CEOP as the First-line Therapy for Newly Diagnosed Adult Patients With Peripheral T-cell Lymphoma (PTCL) Active, not recruiting NCT02533700 Phase 2 CEOP/IVE/GDP chemotherapy regimen;CEOP chemotherapy regimen for 6 cycles
4 Phase 1 Trial of Siplizumab and Dose-Adjusted EPOCH-Rituximab (DA-EPOCH-R) in T and NK-Cell Lymphomas Active, not recruiting NCT01445535 Phase 1 Etoposide;Prednisone;Vincristine;Cyclophosphamide;Doxorubicin
5 Mesenteric Panniculitis : Review of Consecutive Abdominal MDCT Examinations With a Matched-pair Analysis Completed NCT03316001
6 Prospective Collection of Data in Pts With Peripheral T-Cell Lymphoma: PTCL,NOS;AITL; Extranodal NK/T-cell;Enteropathy-type; Hepatosplenic γ-δ; Subcutaneous Panniculitis-like; ALCL,Primary Systemic Type. By the Intl. T-Cell Lymphoma Project Completed NCT01142674
7 A Pilot Feasibility Trial of the Tolerability of Oral Salvia Hispanica and Its Effect on Blood Fatty Acids and Stool Microbiome in Patients With Treated Non-Hodgkin Lymphoma Completed NCT02652715
8 Cyclophosphamide in the Treatment of Panniculitis Associated Acquired Lipodystrophy Syndrome With Type 1 Diabetes Recruiting NCT03936829 Cyclophosphamide
9 Effect of Vitamin D Replacement on Tumor Response and Survival Parameters for Vitamin D Insufficient Patients With Cancer Recruiting NCT01787409
10 Inflammation and Oxidative Stress of Adipose Tissue in Obese and Non-obese Patients Having Sleep Apnea Syndrome Active, not recruiting NCT01196845
11 Prospective Study of Functional and Quality of Life Outcomes in Panniculectomy Patients Terminated NCT01464658

Search NIH Clinical Center for Panniculitis

Cochrane evidence based reviews: panniculitis

Genetic Tests for Panniculitis

Genetic tests related to Panniculitis:

# Genetic test Affiliating Genes
1 Panniculitis 29

Anatomical Context for Panniculitis

MalaCards organs/tissues related to Panniculitis:

40
Skin, Breast, Pancreas, Colon, Kidney, Myeloid, Bone Marrow

Publications for Panniculitis

Articles related to Panniculitis:

(show top 50) (show all 3266)
# Title Authors PMID Year
1
New Findings in PiZZ alpha1-antitrypsin deficiency-related panniculitis. Demonstration of skin polymers and high dosing requirements of intravenous augmentation therapy. 61 54
19218787 2009
2
Alpha1-antitrypsin deficiency: incidence and implications. 54 61
16327507 2005
3
A review of alpha-1 antitrypsin deficiency. 54 61
17136953 2005
4
A review of alpha-1 antitrypsin deficiency. 61 54
16088434 2005
5
Alpha-1-antitrypsin associated panniculitis: the MS variant. 61 54
15389208 2004
6
Nasal-type natural killer cell lymphoma preceded by benign panniculitis arising in an asymptomatic HTLV-1 carrier. 54 61
12956685 2003
7
alpha 1-antitrypsin deficiency-associated panniculitis: resolution with intravenous alpha 1-antitrypsin administration and liver transplantation. 61 54
9039946 1997
8
Pancreatitis, Panniculitis, and Polyarthritis Syndrome Detected on 99mTc-MDP Bone Scan. 61
33323733 2021
9
[Research Progression of Subcutaneous Panniculitis-like T-Cell Lymphoma--Review]. 61
33554838 2021
10
Methicillin-resistant Staphylococcus aureus (MRSA) panniculitis in a patient undergoing stem cell mobilisation. 61
33563686 2021
11
Pancreatic panniculitis in a patient with pancreatic adenosquamous carcinoma. 61
33124679 2021
12
Mesenteric panniculitis and abdominal pain: A casual association? Retrospective case series analysis. 61
33545236 2021
13
Pyogranulomatous panniculitis in a domestic cat associated with Pseudomonas luteola infection. 61
32991013 2021
14
Investigating the presence of neutrophil extracellular traps in septal and lobular cutaneous panniculitides. 61
33580883 2021
15
Lobular panniculitis associated with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. 61
32840874 2021
16
Patient and parent perspectives on transition from paediatric to adult healthcare in rheumatic diseases: an interview study. 61
33397662 2021
17
A Rare Case of Subcutaneous Panniculitis-Like T Cell Lymphoma with Hemophagocytic Lymphohistiocytosis Mimicking Cellulitis. 61
33428607 2021
18
Subcutaneous Panniculitis-like T-Cell Lymphoma With Hemophagocytic Lymphohistiocytosis Syndrome in Children and Its Essential Role of HAVCR2 Gene Mutation Analysis. 61
33003142 2021
19
Treatment considerations in case of subcutaneous panniculitis like T cell lymphoma with hemophagocytic syndrome. 61
33404186 2021
20
Venetoclax-induced panniculitis in an acute myeloid leukemia patient. 61
33439305 2021
21
Alpha-1 Antitrypsin Deficiency Associated Panniculitis. 61
33516773 2021
22
GATA2 mutation with recurrent hemophagocytic lymphohistiocytosis and panniculitis: a case report. 61
33410496 2021
23
Lupus erythematosus: Significance of dermatologic findings. 61
33483145 2021
24
A case report and literature review of cutaneous intravascular large B-cell lymphoma presenting clinically as panniculitis: a difficult diagnosis, but a good prognosis. 61
33261907 2021
25
Ultrasonography for assessing the disease activity of sclerodermoid lupus erythematosus panniculitis. 61
33580941 2021
26
Dasatinib-induced panniculitis in a patient with chronic myeloid leukaemia. 61
33495146 2021
27
Panniculitis as the first clinical manifestation of MPO-positive ANCA-associated vasculitis. 61
33497034 2021
28
Cutaneous mucormycosis mimicking pancreatic panniculitis. 61
33470453 2021
29
Intravenous Immune Globulin (IVIG) Therapy After Unsuccessful Treatment with Corticosteroid and Cyclosporine A in Pfeifer-Weber-Christian Disease: A Case Report. 61
33390586 2021
30
Response: Cutaneous manifestations of anti-neutrophil cytoplasmic antibody-associated vasculitis. 61
33497001 2021
31
Cutaneous Coinfection of Cytomegalovirus and Mycobacterium chelonae Accelerated by Immunosuppression. 61
33564484 2021
32
Inflammation and infarction of adipose tissue: implications in bariatric surgery. 61
32969263 2021
33
Complete response to romidepsin as monotherapy in treatment-resistant subcutaneous panniculitis-like T-cell lymphoma. 61
33294555 2020
34
Neutrophilic dermatosis: a new skin manifestation and novel pathogenic variant in a rare autoinflammatory disease. 61
33332575 2020
35
Viral panniculitis in a patient with disseminated opportunistic Enterovirus infection. 61
33277938 2020
36
Panniculitis in a patient with metastatic renal cell carcinoma on a tyrosine kinase inhibitor. 61
33290313 2020
37
Dermatological Toxicities of Bruton's Tyrosine Kinase Inhibitors. 61
32613545 2020
38
Pembrolizumab-Induced Sarcoid-Like Reaction in a Patient With Lung Cancer. 61
33409108 2020
39
Ulcerative necrobiosis lipoidica with granulomatous vasculitis mimicking sclerosing panniculitis in a patient with sarcoidosis. 61
32614071 2020
40
Recognizing the Ultrasound Patterns of Mesenteric Panniculitis. 61
33394995 2020
41
Panniculitis in a Woman With Opportunistic Pulmonary Coinfection by Pneumocystis jirovecii and Cryptococcus neoformans: 18F-FDG PET/CT Revealing the Infection and Assessing Treatment Response. 61
33315665 2020
42
Mesenteric Panniculitis, A Rare Entity Causing Intestinal Obstruction. 61
33295212 2020
43
[Panniculitis during BRAF inhibitor and/or MEK inhibitor therapy: A new case report and literature review]. 61
32948319 2020
44
Symmetrical Panniculitis in a Patient With Dermatomyositis: An Unusual Onset. 61
31651642 2020
45
Rare complication of endoscopic band ligation for colonic diverticular bleeding. 61
33319068 2020
46
Not only fat: omental infarction and its mimics in children. Clinical and ultrasound findings: a pictorial review. 61
32623635 2020
47
Cutaneous side effects in a cohort of patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: General description and further characterization, correlation with photoexposition and study of hypopigmentation as treatment's prognostic factor. 61
33073453 2020
48
Subcutaneous fat necrosis of the newborn: clinical and histopathological review and use of cutaneous ultrasound Necrosis grasa subcutánea del recién nacido: revisión clínica e histopatológica y utilidad de la ecografía cutánea. 61
33342185 2020
49
Dermatologic sequelae of breast cancer: From disease, surgery, and radiation. 61
33226140 2020
50
Disseminated panniculitis with subcutaneous abscesses and fat necrosis associated with alpha-1 antitrypsin deficiency. 61
32657012 2020

Variations for Panniculitis

Expression for Panniculitis

Search GEO for disease gene expression data for Panniculitis.

Pathways for Panniculitis

Pathways related to Panniculitis according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.08 TIA1 PSMB9 PSMB8 PSMB4 OTULIN NCAM1
2
Show member pathways
13.84 SERPINA1 PSMB9 PSMB8 PSMB4 NCAM1 MYC
3
Show member pathways
13.64 MYC IL2RA IFNG FASLG FAS CSF3
4
Show member pathways
13.51 PSMB9 PSMB8 PSMB4 MYC IL2RA IFNG
5
Show member pathways
12.98 MYC IFNG FASLG FAS CASP3 BTK
6
Show member pathways
12.95 MYC IL2RA FASLG FAS CSF3 CASP3
7
Show member pathways
12.84 PSMB9 PSMB8 PSMB4 NCAM1 MYC IL2RA
8
Show member pathways
12.79 IL2RA IFNG GZMB FASLG FAS CASP3
9 12.75 MYC IL2RA IFNG FASLG FAS CASP3
10 12.73 MYC FASLG FAS CASP3 BRAF
11
Show member pathways
12.69 MYC IL2RA IFNG FASLG FAS CASP3
12
Show member pathways
12.67 MYC GZMB FASLG FAS CASP3
13
Show member pathways
12.61 IFNG FASLG FAS CASP3 BRAF
14
Show member pathways
12.52 PSMB9 PSMB8 PSMB4 MYC FASLG FAS
15
Show member pathways
12.43 PSMB9 PSMB8 PSMB4 BTK
16
Show member pathways
12.41 IFNG GZMB FASLG FAS CASP3 BRAF
17 12.38 PSMB9 PSMB8 PSMB4 MYC
18
Show member pathways
12.37 MYC IL2RA IFNG CSF3
19
Show member pathways
12.26 FASLG FAS CASP3 BTK
20 12.23 MYC FASLG FAS CASP3 BRAF
21
Show member pathways
12.21 PSMB4 FASLG FAS CASP3
22
Show member pathways
12.16 GZMB FASLG FAS CASP3
23 12.14 MYC IFNG CASP3 BRAF
24 12.07 TIA1 MYC GZMB FASLG FAS CASP3
25 12.06 PSMB9 PSMB8 PSMB4 CASP3
26
Show member pathways
12.01 MYC IL2RA IFNG BTK
27 11.94 NCAM1 IL2RA IFNG CSF3
28
Show member pathways
11.91 IL2RA IFNG GZMB FASLG
29 11.84 PSMB8 OTULIN NCAM1 IL2RA IFNG HAVCR2
30
Show member pathways
11.77 FASLG FAS CASP3
31 11.71 FASLG FAS CASP3
32 11.71 NCAM1 IL2RA IFNG GZMB
33
Show member pathways
11.68 IL2RA IFNG FASLG CASP3
34
Show member pathways
11.66 MYC IL2RA FASLG
35 11.52 IFNG FASLG FAS
36 11.51 MYC FASLG CASP3
37 11.47 MYC IL2RA BTK
38
Show member pathways
11.44 IL2RA IFNG GZMB FASLG BRAF
39 11.34 IFNG FASLG FAS
40
Show member pathways
11.11 IL2RA IFNG GZMB FASLG FAS

GO Terms for Panniculitis

Cellular components related to Panniculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.67 FASLG FAS CASP3 BTK
2 proteasome complex GO:0000502 9.5 PSMB9 PSMB8 PSMB4
3 death-inducing signaling complex GO:0031264 9.26 FAS CASP3
4 spermatoproteasome complex GO:1990111 9.16 PSMB9 PSMB8
5 proteasome core complex GO:0005839 9.13 PSMB9 PSMB8 PSMB4
6 proteasome core complex, beta-subunit complex GO:0019774 8.8 PSMB9 PSMB8 PSMB4

Biological processes related to Panniculitis according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 10.05 PSMB9 PSMB8 OTULIN IL2RA HAVCR2 BTK
2 immune response GO:0006955 10 IL2RA IFNG FASLG FAS CSF3
3 proteolysis GO:0006508 9.93 PSMB9 PSMB8 PSMB4 OTULIN GZMB CASP3
4 protein deubiquitination GO:0016579 9.92 PSMB9 PSMB8 PSMB4 MYC
5 interleukin-1-mediated signaling pathway GO:0070498 9.81 PSMB9 PSMB8 PSMB4
6 T cell receptor signaling pathway GO:0050852 9.81 PSMB9 PSMB8 PSMB4 BRAF
7 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 9.8 PSMB9 PSMB8 PSMB4
8 Fc-epsilon receptor signaling pathway GO:0038095 9.8 PSMB9 PSMB8 PSMB4 BTK
9 cytokine-mediated signaling pathway GO:0019221 9.8 MYC IL2RA FASLG CSF3 CASP3
10 Wnt signaling pathway, planar cell polarity pathway GO:0060071 9.79 PSMB9 PSMB8 PSMB4
11 anaphase-promoting complex-dependent catabolic process GO:0031145 9.79 PSMB9 PSMB8 PSMB4
12 regulation of mitotic cell cycle phase transition GO:1901990 9.78 PSMB9 PSMB8 PSMB4
13 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.77 PSMB9 PSMB8 PSMB4
14 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 9.76 PSMB9 PSMB8 PSMB4
15 NIK/NF-kappaB signaling GO:0038061 9.74 PSMB9 PSMB8 PSMB4
16 regulation of hematopoietic stem cell differentiation GO:1902036 9.73 PSMB9 PSMB8 PSMB4
17 negative regulation of G2/M transition of mitotic cell cycle GO:0010972 9.71 PSMB9 PSMB8 PSMB4
18 regulation of cellular amino acid metabolic process GO:0006521 9.65 PSMB9 PSMB8 PSMB4
19 macrophage activation involved in immune response GO:0002281 9.64 IFNG HAVCR2
20 apoptotic signaling pathway GO:0097190 9.62 FASLG FAS CASP3 BTK
21 extrinsic apoptotic signaling pathway GO:0097191 9.61 IFNG FASLG FAS
22 proteolysis involved in cellular protein catabolic process GO:0051603 9.56 PSMB9 PSMB8 PSMB4 GZMB
23 apoptotic process GO:0006915 9.56 TIA1 IL2RA IFNG GZMB FASLG FAS
24 necroptotic signaling pathway GO:0097527 9.55 FASLG FAS
25 tumor necrosis factor-mediated signaling pathway GO:0033209 9.55 PSMB9 PSMB8 PSMB4 FASLG FAS
26 proteasomal ubiquitin-independent protein catabolic process GO:0010499 9.54 PSMB9 PSMB8 PSMB4
27 activation-induced cell death of T cells GO:0006924 9.52 IL2RA FAS
28 MAPK cascade GO:0000165 9.17 PSMB9 PSMB8 PSMB4 NCAM1 MYC IL2RA

Molecular functions related to Panniculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.13 TIA1 SERPINA1 PSMB9 PSMB8 PSMB4 OTULIN
2 endopeptidase activity GO:0004175 9.43 PSMB9 PSMB8 PSMB4
3 peptidase activity GO:0008233 9.43 PSMB9 PSMB8 PSMB4 OTULIN GZMB CASP3
4 threonine-type endopeptidase activity GO:0004298 8.8 PSMB9 PSMB8 PSMB4

Sources for Panniculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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