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MCID: PNN001
MIFTS: 51

Panniculitis

Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Panniculitis

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MalaCards integrated aliases for Panniculitis:

Name: Panniculitis 12 74 29 54 43 15 17 71

Classifications:

MalaCards categories:
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:1526
ICD9CM 34 729.30
MeSH 43 D015434
NCIt 49 C112112
SNOMED-CT 67 22125009
ICD10 32 M79.3
UMLS 71 C0030326
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Summaries for Panniculitis

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MalaCards based summary : Panniculitis is related to t-cell lymphoma, subcutaneous panniculitis-like and proteasome-associated autoinflammatory syndrome 1, and has symptoms including pruritus, myalgia and exanthema. An important gene associated with Panniculitis is HAVCR2 (Hepatitis A Virus Cellular Receptor 2), and among its related pathways/superpathways are Signaling by GPCR and Innate Immune System. The drugs Doxorubicin and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and neutrophil, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Increased viability with MLN4924 (a NAE inhibitor)

Wikipedia : 74 Panniculitis is a group of diseases whose hallmark is inflammation of subcutaneous adipose tissue (the... more...

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Related Diseases for Panniculitis

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Diseases related to Panniculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 677)
# Related Disease Score Top Affiliating Genes
1 t-cell lymphoma, subcutaneous panniculitis-like 34.2 TNFRSF8 TIA1 HAVCR2 GZMB
2 proteasome-associated autoinflammatory syndrome 1 33.6 PSMB8 PSMB4 IFNG
3 proteasome-associated autoinflammatory syndrome 3 32.5 PSMB9 PSMB4
4 autoimmune lymphoproliferative syndrome 31.0 GZMB FASLG FAS CD8A
5 hemophagocytic lymphohistiocytosis 30.5 IFNG HAVCR2 GZMB FAS
6 exanthem 30.3 IFNG CSF3 CD8A
7 lymphomatoid granulomatosis 30.2 TIA1 GZMB
8 lymphoma, hodgkin, classic 30.2 TNFRSF8 TIA1 GZMB CSF3
9 histiocytosis 30.1 TNFRSF8 IFNG BRAF
10 pancytopenia 30.1 NCAM1 IFNG CSF3 CD8A
11 soft tissue sarcoma 30.1 IFNG CSF3
12 autoimmune disease 30.0 PSMB9 IFNG HAVCR2 FASLG FAS
13 polyarticular juvenile idiopathic arthritis 30.0 IFNG BTK
14 pulmonary emphysema 29.8 SERPINA1 IFNG CASP3
15 cutaneous t cell lymphoma 29.8 TNFRSF8 TIA1 IFNG GZMB FAS
16 graft-versus-host disease 29.7 IFNG GZMB FASLG FAS
17 acute graft versus host disease 29.7 IFNG FASLG CSF3
18 composite lymphoma 29.6 TNFRSF8 TIA1 GZMB
19 lymphopenia 29.6 IFNG FASLG FAS BTK
20 angioimmunoblastic t-cell lymphoma 29.5 TNFRSF8 TIA1 GZMB
21 mantle cell lymphoma 29.5 MYC CSF3 CASP3 BTK
22 syphilis 29.5 IFNG FAS CD8A
23 lymphadenitis 29.5 IFNG FASLG FAS CASP3
24 lichen sclerosus et atrophicus 29.4 TIA1 GZMB CD8A
25 viral hepatitis 29.3 SERPINA1 IFNG FASLG FAS
26 pediatric lymphoma 29.3 TNFRSF8 TIA1 NCAM1 MYC
27 bacterial infectious disease 29.3 IFNG CSF3 CD8A BTK
28 aplastic anemia 29.3 IFNG HAVCR2 FASLG FAS CSF3
29 peripheral t-cell lymphoma 29.2 TNFRSF8 TIA1 NCAM1 GZMB CD8A
30 diffuse large b-cell lymphoma 29.2 TNFRSF8 MYC CSF3 BTK
31 mycosis fungoides 29.2 TNFRSF8 TIA1 NCAM1 IFNG GZMB
32 b-cell lymphoma 29.1 TNFRSF8 TIA1 MYC FAS CASP3 BTK
33 hashimoto thyroiditis 29.0 IFNG FASLG FAS BRAF
34 immune deficiency disease 29.0 TNFRSF8 IFNG FASLG FAS BTK
35 lymphoma 29.0 TNFRSF8 TIA1 MYC HAVCR2 GZMB FAS
36 peripheral nervous system disease 29.0 IFNG CSF3 CD8A CASP3
37 thrombocytopenia 28.7 PSMB9 IFNG HAVCR2 GZMB FASLG FAS
38 acute promyelocytic leukemia 28.7 NCAM1 MYC FAS CSF3 CASP3
39 gastric adenocarcinoma 28.6 MYC IFNG FASLG FAS CASP3 BRAF
40 pneumonia 28.6 SERPINA1 IFNG CSF3 CD8A
41 asthma 28.5 SERPINA1 IFNG HAVCR2 GZMB FASLG FAS
42 celiac disease 1 28.5 TIA1 SERPINA1 NCAM1 IFNG GZMB CD8A
43 common variable immunodeficiency 28.5 TNFRSF8 SERPINA1 IFNG GZMB FAS BTK
44 renal cell carcinoma, nonpapillary 28.4 PSMB9 PSMB8 IFNG FASLG FAS BRAF
45 leukemia, acute lymphoblastic 28.4 MYC CSF3 CD8A CASP3 BTK
46 leukemia, chronic myeloid 28.4 MYC GZMB CSF3 CD8A CASP3
47 t-cell lymphoblastic leukemia/lymphoma 28.4 TNFRSF8 MYC FASLG FAS CASP3
48 mycobacterium tuberculosis 1 28.3 TNFRSF8 SERPINA1 IFNG GZMB CD8A
49 lung cancer susceptibility 3 27.7 SERPINA1 MYC FAS CD8A CASP3 BRAF
50 sezary's disease 27.6 TNFRSF8 TIA1 NCAM1 NAV3 MYC IFNG

Graphical network of the top 20 diseases related to Panniculitis:



Diseases related to Panniculitis
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Symptoms & Phenotypes for Panniculitis

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UMLS symptoms related to Panniculitis:


pruritus, myalgia, exanthema, decreased adipose tissue, other musculoskeletal symptoms referable to limbs, pain in limb, integumentary system signs and symptoms

GenomeRNAi Phenotypes related to Panniculitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-1 9.93 TIA1
2 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-2 9.93 BRAF BTK CASP3 FAS FASLG GZMB
3 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.93 BRAF
4 Reduced mammosphere formation GR00396-S 9.5 BRAF CSF3 FAS FASLG MYC NCAM1
5 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.4 CASP3 FAS GZMB NAV3 PSMB8 PSMB9
6 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.4 CASP3 FAS GZMB NAV3 PSMB8 PSMB9

MGI Mouse Phenotypes related to Panniculitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.24 BRAF BTK CASP3 CD8A CSF3 FAS
2 immune system MP:0005387 10.2 BRAF BTK CASP3 CD8A CSF3 FAS
3 cellular MP:0005384 10.14 BRAF BTK CASP3 CD8A FAS FASLG
4 mortality/aging MP:0010768 9.97 BRAF BTK CASP3 CD8A FAS FASLG
5 integument MP:0010771 9.91 BRAF BTK CASP3 CD8A CSF3 FAS
6 neoplasm MP:0002006 9.56 BRAF BTK FAS FASLG IFNG MYC
7 renal/urinary system MP:0005367 9.23 BRAF CASP3 CD8A CSF3 FAS FASLG
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Drugs & Therapeutics for Panniculitis

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Drugs for Panniculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 4 23214-92-8 31703
2
Methotrexate Approved Phase 4 59-05-2, 1959-05-2 126941
3
Pirarubicin Investigational Phase 4 72496-41-4
4 Alkylating Agents Phase 4
5 Antineoplastic Agents, Hormonal Phase 4
6 Tubulin Modulators Phase 4
7 Hormone Antagonists Phase 4
8
Liposomal doxorubicin Phase 4 31703
9 Anti-Bacterial Agents Phase 4
10 glucocorticoids Phase 4
11 Dermatologic Agents Phase 4
12 Antibiotics, Antitubercular Phase 4
13 Anti-Inflammatory Agents Phase 4
14 Antimitotic Agents Phase 4
15
Methylcobalamin Approved, Investigational Phase 1, Phase 2 13422-55-4
16
Hydroxocobalamin Approved Phase 1, Phase 2 13422-51-0 15589840 11953898
17
leucovorin Approved Phase 1, Phase 2 58-05-9 6006 143
18
Pembrolizumab Approved Phase 1, Phase 2 1374853-91-4
19
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
20
Vincristine Approved, Investigational Phase 2 57-22-7, 2068-78-2 5978
21
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
22
Ifosfamide Approved Phase 2 3778-73-2 3690
23
Etoposide Approved Phase 2 33419-42-0 36462
24
Gemcitabine Approved Phase 2 95058-81-4 60750
25
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
26
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
27
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
28
Cyanocobalamin Approved, Nutraceutical Phase 1, Phase 2 68-19-9 44176380
29
Folic acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
30
Cobalamin Experimental Phase 1, Phase 2 13408-78-1 6857388
31
tipifarnib Investigational Phase 2 192185-72-1 159324
32 Antimetabolites Phase 1, Phase 2
33 Trace Elements Phase 1, Phase 2
34 Micronutrients Phase 1, Phase 2
35 Vitamins Phase 1, Phase 2
36 Nutrients Phase 1, Phase 2
37 Vitamin B 12 Phase 1, Phase 2
38 Hematinics Phase 1, Phase 2
39 Anti-Infective Agents Phase 1, Phase 2
40 Antiviral Agents Phase 1, Phase 2
41 Vitamin B12 Phase 1, Phase 2
42 Folic Acid Antagonists Phase 1, Phase 2
43 Vitamin B Complex Phase 1, Phase 2
44 Folate Phase 1, Phase 2
45 Vitamin B9 Phase 1, Phase 2
46 10-deazaaminopterin Phase 1, Phase 2
47 Etoposide phosphate Phase 2
48
Isophosphamide mustard Phase 2 0
49
rituximab Approved Phase 1 174722-31-7 10201696
50
Everolimus Approved Phase 1 159351-69-6 70789204 6442177

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 An Open-label,Multicenter Randomised Study of CTOP/ITE/MTX Compared With CHOP as the First-line Therapy for the New Diagnosed Young Patients With T Cell Non-hodgkin Lymphoma Unknown status NCT01746992 Phase 4 Cyclophosphamide 750mg/m2;Vincristine 1.4mg/m2;Doxorubicin 50mg/m2;prednisone 60mg/m2;ifosfamide 2000mg/m2;pirarubicin 50mg/m2;pirarubicin 25mg/m2;Etoposide phosphate 100mg/m2;methotrexate 1500mg/m2
2 A Phase 1/2a Open-label Study of Pralatrexate and Gemcitabine With Vitamin B12 and Folic Acid Supplementation in Patients With Relapsed or Refractory Lymphoproliferative Malignancies Completed NCT00481871 Phase 1, Phase 2 Pralatrexate Injection;Gemcitabine Hydrochloride
3 An Open Label Phase II Study of Tipifarnib in Subjects With Relapsed or Refractory Peripheral T-Cell Lymphoma Recruiting NCT02464228 Phase 2 Tipifarnib
4 A Phase 1/2 Study of Pembrolizumab Plus Pralatrexate for Treatment of Relapsed or Refractory Peripheral T-Cell Lymphomas Recruiting NCT03598998 Phase 1, Phase 2 Pralatrexate
5 CEOP/IVE/GDP Compared With CEOP as the First-line Therapy for Newly Diagnosed Adult Patients With Peripheral T-cell Lymphoma (PTCL) Active, not recruiting NCT02533700 Phase 2 CEOP/IVE/GDP chemotherapy regimen;CEOP chemotherapy regimen for 6 cycles
6 Phase 1 Trial of Siplizumab and Dose-Adjusted EPOCH-Rituximab (DA-EPOCH-R) in T and NK-Cell Lymphomas Active, not recruiting NCT01445535 Phase 1 EPOCH
7 A Phase 1 Trial of the Combination of Everolimus (RAD001) and Bortezomib (VELCADE) for Relapsed or Refractory Lymphoma Terminated NCT00671112 Phase 1 Bortezomib;Everolimus
8 Mesenteric Panniculitis : Review of Consecutive Abdominal MDCT Examinations With a Matched-pair Analysis Completed NCT03316001
9 A Pilot Feasibility Trial of the Tolerability of Oral Salvia Hispanica and Its Effect on Blood Fatty Acids and Stool Microbiome in Patients With Treated Non-Hodgkin Lymphoma Completed NCT02652715
10 Characterization of Transient Alterations of Cutaneous Sensory Nerve Function by Cryolipolysis Completed NCT01673113
11 Prospective Collection of Data in Pts With Peripheral T-Cell Lymphoma: PTCL,NOS;AITL; Extranodal NK/T-cell;Enteropathy-type; Hepatosplenic γ-δ; Subcutaneous Panniculitis-like; ALCL,Primary Systemic Type. By the Intl. T-Cell Lymphoma Project Completed NCT01142674
12 Cyclophosphamide in the Treatment of Panniculitis Associated Acquired Lipodystrophy Syndrome With Type 1 Diabetes Recruiting NCT03936829 Cyclophosphamide
13 Effect of Vitamin D Replacement on Tumor Response and Survival Parameters for Vitamin D Insufficient Patients With Cancer Recruiting NCT01787409
14 Inflammation and Oxidative Stress of Adipose Tissue in Obese and Non-obese Patients Having Sleep Apnea Syndrome Active, not recruiting NCT01196845
15 Prospective Study of Functional and Quality of Life Outcomes in Panniculectomy Patients Terminated NCT01464658

Search NIH Clinical Center for Panniculitis

Cochrane evidence based reviews: panniculitis

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Genetic Tests for Panniculitis

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Genetic tests related to Panniculitis:

# Genetic test Affiliating Genes
1 Panniculitis 29
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Anatomical Context for Panniculitis

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MalaCards organs/tissues related to Panniculitis:

40
T Cells, Skin, Neutrophil, Breast, Pancreas, Nk Cells, Colon
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Publications for Panniculitis

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Articles related to Panniculitis:

(show top 50) (show all 3168)
# Title Authors PMID Year
1
New Findings in PiZZ alpha1-antitrypsin deficiency-related panniculitis. Demonstration of skin polymers and high dosing requirements of intravenous augmentation therapy. 61 54
19218787 2009
2
Alpha1-antitrypsin deficiency: incidence and implications. 54 61
16327507 2005
3
A review of alpha-1 antitrypsin deficiency. 61 54
17136953 2005
4
A review of alpha-1 antitrypsin deficiency. 61 54
16088434 2005
5
Alpha-1-antitrypsin associated panniculitis: the MS variant. 54 61
15389208 2004
6
Nasal-type natural killer cell lymphoma preceded by benign panniculitis arising in an asymptomatic HTLV-1 carrier. 54 61
12956685 2003
7
alpha 1-antitrypsin deficiency-associated panniculitis: resolution with intravenous alpha 1-antitrypsin administration and liver transplantation. 54 61
9039946 1997
8
Rare non-Hodgkin lymphoma of childhood and adolescence: A consensus diagnostic and therapeutic approach to pediatric-type follicular lymphoma, marginal zone lymphoma, and nonanaplastic peripheral T-cell lymphoma. 61
32452165 2020
9
Mesenteric panniculitis mimicking early recurrence at end-of-treatment evaluation in malignant lymphoma: Differentiation by active surveillance with F-18 FDG PET/CT imaging. 61
32426085 2020
10
Pancreatic panniculitis as an initial manifestation of locally advanced pancreatic cancer. 61
32249093 2020
11
Cutaneous leishmaniasis: a pathological study of 360 cases with special emphasis on the contribution of immunohistochemistry and polymerase chain reaction to diagnosis. 61
32578232 2020
12
TIM-3 deficiency presenting with two clonally unrelated episodes of mesenteric and subcutaneous panniculitis-like T-cell lymphoma and hemophagocytic lymphohistiocytosis. 61
32285995 2020
13
Panniculitis-Like Presentation of Extracavitary Primary Effusion Lymphoma. 61
31592862 2020
14
Painful Panniculitis and Polyarthritis in Pancreatic Adenocarcinoma: A Case Report. 61
32496359 2020
15
Intraosseous Medullary Fat Necrosis on 99mTc-MDP Bone Scan of Patient With Acute Pancreatitis. 61
32332310 2020
16
Tuberculous peritonitis; The effectiveness of diagnostic laparoscopy and the perioperative infectious prevention: A case report. 61
32563096 2020
17
Treatment of Facial Lipoatrophy Secondary to Subcutaneous Panniculitis-Like T-Cell Lymphoma. 61
30829756 2020
18
Second primary malignancies in subcutaneous panniculitis-like T-cell lymphoma: a national database study. 61
32359183 2020
19
Erythema Nodosum, Early Stage-A Subcutaneous Variant of Leukocytoclastic Vasculitis? Clinicopathological Correlation in a Series of 13 Patients. 61
31436577 2020
20
Panniculitis as main clinical manifestation of alpha-1 antitrypsin deficiency revealing a SerpinA1 gene mutation. 61
32430912 2020
21
The epidemiology of subcutaneous panniculitis-like alpha-beta T-cell lymphoma in New Zealand. 61
31868922 2020
22
Panniculitis following baricitinib initiation for treatment of rheumatoid arthritis. 61
32461123 2020
23
Eosinophilic Panniculitis Associated With COVID-19. 61
32450058 2020
24
Dermatologic Sequelae Associated with Radiation Therapy. 61
32410134 2020
25
Emerging Zoonotic Diseases in Ferrets. 61
32327037 2020
26
Lesser Omental Panniculitis. 61
32461523 2020
27
Nodular panniculitis in a cat with high alpha tocopherol concentration in serum. 61
32421260 2020
28
Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases. 61
31874111 2020
29
Efficacy of ruxolitinib in subcutaneous panniculitis-like T-cell lymphoma and hemophagocytic lymphohistiocytosis. 61
32271897 2020
30
Lesser omental panniculitis: a possible cause of acute abdomen. 61
31440908 2020
31
TAFRO Syndrome Presenting with Retroperitoneal Panniculitis-like Computed Tomography Findings at Disease Onset. 61
31839656 2020
32
A rare case of a patient with PPP syndrome presenting pancreatic pseudocysts, panniculitis, and symptoms of polyarthritis. A radicular cyst of the upper jaw could be another manifestation of the syndrome. 61
32274023 2020
33
Under the skin: Ixodes ticks in the subcutaneous tissue of red foxes (Vulpes vulpes) from Germany. 61
32312296 2020
34
HAVCR2 mutations are associated with severe hemophagocytic syndrome in subcutaneous panniculitis-like T-cell lymphoma. 61
32005988 2020
35
Lipoatrophic panniculitis in an adolescent. 61
32198786 2020
36
A retrospective review of cutaneous lymphoma in Botswana. 61
31647120 2020
37
Sterile traumatic panniculitis in a captive Brent goose. 61
32100641 2020
38
Imaging of idiopathic nonsuppurative nodular panniculitis of breast. 61
31538369 2020
39
Panniculitis with an unusual diagnosis. 61
30932212 2020
40
Panniculitis as an Initial Presentation of Dermatomyositis: A Case Report. 61
32347826 2020
41
Activated-cytotoxic TCRαβ+CD4+ peripheral T-cell lymphoma with hypodermal localization: Case report of a lymphoproliferative disorder probably evolved from the CD4+ cytotoxic T-cell subpopulation. 61
31595546 2020
42
Draft Genome Sequence of a Mycobacterium porcinum Strain Isolated from a Pet Cat with Atypical Mycobacterial Panniculitis. 61
32165379 2020
43
Subcutaneous mixed lobular and septal panniculitis with numerous eosinophils associated with autologous fat grafting: Expanding the differential diagnosis of eosinophilic panniculitis. 61
31774571 2020
44
Intralesional overlap syndrome: Sclerodermic lupus panniculitis and sclerodermic discoid lupus erythematosus. 61
32083161 2020
45
Neutrophilic panniculitis arising from hematogenous spread of methicillin-resistant Staphylococcus aureus. 61
32124476 2020
46
Early-onset granulomatous arthritis, uveitis and skin rash: characterization of skin involvement in Blau syndrome. 61
31541486 2020
47
Erythema nodosum induced by oral isotretinoin in a patient with condylomata acuminata. 61
32239897 2020
48
Mesenteric panniculitis in a patient with new onset dermatomyositis. 61
32014990 2020
49
Pralatrexate for refractory or recurrent subcutaneous panniculitis-like T-cell lymphoma with hemophagocytic syndrome. 61
31319088 2020
50
Subcutaneous Panniculitis-Like T Cell Lymphoma: Approach to Differential Diagnosis on Cytology. 61
31580741 2020
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Variations for Panniculitis

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Expression for Panniculitis

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Search GEO for disease gene expression data for Panniculitis.
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Pathways for Panniculitis

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Pathways related to Panniculitis according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Signaling by GPCR 65
Show member pathways
 14.13 TIA1 PSMB9 PSMB8 PSMB4 OTULIN NCAM1
2
Innate Immune System 65
Show member pathways
 13.72 TNFRSF8 SERPINA1 PSMB9 PSMB8 PSMB4 NCAM1
3
PEDF Induced Signaling 63
Show member pathways
 13.64 TNFRSF8 MYC IFNG FASLG FAS CSF3
4
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 12.94 MYC IFNG FASLG FAS CASP3 BTK
5
Cytokine Signaling in Immune system 65
Show member pathways
 12.84 TNFRSF8 PSMB9 PSMB8 PSMB4 NCAM1 MYC
6
Pathways in cancer 36
12.78 MYC IFNG FASLG FAS CASP3 BRAF
7
Allograft rejection 1 36
Show member pathways
 12.77 IFNG GZMB FASLG FAS CD8A CASP3
8
MAPK signaling pathway 36 1
12.72 MYC FASLG FAS CASP3 BRAF
9
Measles 36
Show member pathways
 12.72 MYC IFNG FASLG FAS CASP3 BTK
10
Apoptosis Modulation and Signaling 1
Show member pathways
 12.66 MYC GZMB FASLG FAS CASP3
11
Apoptotic execution phase 65
Show member pathways
 12.64 PSMB9 PSMB8 PSMB4 GZMB FASLG FAS
12
4-1BB Pathway 63
Show member pathways
 12.6 IFNG FASLG FAS CASP3 BRAF
13
Chks in Checkpoint Regulation 63
Show member pathways
 12.55 PSMB9 PSMB8 PSMB4 MYC FASLG FAS
14
Antigen processing-Cross presentation 65
Show member pathways
 12.41 PSMB9 PSMB8 PSMB4 CD8A BTK
15
Immune response Role of DAP12 receptors in NK cells 22
Show member pathways
 12.41 IFNG GZMB FASLG FAS CASP3 BRAF
16
WNT Signaling 63
12.37 PSMB9 PSMB8 PSMB4 MYC
17
CASP8 activity is inhibited 65
Show member pathways
 12.25 FASLG FAS CASP3 BTK
18
p53 Signaling 63
Show member pathways
 12.2 PSMB4 FASLG FAS CASP3
19
Proteoglycans in cancer 36
12.2 MYC FASLG FAS CASP3 BRAF
20
Apoptosis and survival Caspase cascade 22
Show member pathways
 12.15 GZMB FASLG FAS CASP3
21
Colorectal Cancer Metastasis 63
12.13 MYC IFNG CASP3 BRAF
22
Apoptosis and Autophagy 4
12.07 TIA1 MYC GZMB FASLG FAS CASP3
23
Presenilin-Mediated Signaling 63
12.05 PSMB9 PSMB8 PSMB4 CASP3
24
Hematopoietic Stem Cells and Lineage-specific Markers 64
11.92 NCAM1 IFNG CSF3 CD8A
25
IL12-mediated signaling events 1
Show member pathways
 11.88 IFNG GZMB FASLG CD8A
26
NF-kappaB Signaling 4
11.88 TNFRSF8 PSMB8 OTULIN NCAM1 IFNG HAVCR2
27
Nanomaterial induced apoptosis 1
Show member pathways
 11.76 FASLG FAS CASP3
28
TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions 64
Show member pathways
 11.76 TNFRSF8 FASLG FAS
29
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.72 IFNG FASLG CASP3
30
Dendritic Cells Developmental Lineage Pathway 64
11.7 NCAM1 IFNG CD8A
31
Platinum drug resistance 36
11.69 FASLG FAS CASP3
32
Innate Lymphoid Cells Differentiation 64
11.68 NCAM1 IFNG GZMB CD8A
33
Photodynamic therapy-induced AP-1 survival signaling. 1
11.51 IFNG FASLG FAS
34
Hepatitis C and Hepatocellular Carcinoma 1
11.51 MYC FASLG CASP3
35
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.34 IFNG GZMB FASLG CD8A BRAF
36
African trypanosomiasis 36
11.33 IFNG FASLG FAS
37
IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types 64
Show member pathways
 11.23 IFNG GZMB FASLG FAS
Sources

GO Terms for Panniculitis

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Cellular components related to Panniculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.67 FASLG FAS CASP3 BTK
2 proteasome complex GO:0000502 9.5 PSMB9 PSMB8 PSMB4
3 death-inducing signaling complex GO:0031264 9.26 FAS CASP3
4 spermatoproteasome complex GO:1990111 9.16 PSMB9 PSMB8
5 proteasome core complex GO:0005839 9.13 PSMB9 PSMB8 PSMB4
6 proteasome core complex, beta-subunit complex GO:0019774 8.8 PSMB9 PSMB8 PSMB4

Biological processes related to Panniculitis according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 10.03 PSMB9 PSMB8 OTULIN HAVCR2 CD8A BTK
2 immune response GO:0006955 10 IFNG FASLG FAS CSF3 CD8A
3 protein deubiquitination GO:0016579 9.93 PSMB9 PSMB8 PSMB4 MYC
4 proteolysis GO:0006508 9.91 PSMB9 PSMB8 PSMB4 OTULIN GZMB CASP3
5 interleukin-1-mediated signaling pathway GO:0070498 9.81 PSMB9 PSMB8 PSMB4
6 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 9.81 PSMB9 PSMB8 PSMB4
7 T cell receptor signaling pathway GO:0050852 9.81 PSMB9 PSMB8 PSMB4 BRAF
8 Fc-epsilon receptor signaling pathway GO:0038095 9.8 PSMB9 PSMB8 PSMB4 BTK
9 apoptotic process GO:0006915 9.8 TIA1 IFNG GZMB FASLG FAS CASP3
10 Wnt signaling pathway, planar cell polarity pathway GO:0060071 9.79 PSMB9 PSMB8 PSMB4
11 anaphase-promoting complex-dependent catabolic process GO:0031145 9.79 PSMB9 PSMB8 PSMB4
12 regulation of mitotic cell cycle phase transition GO:1901990 9.78 PSMB9 PSMB8 PSMB4
13 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.77 PSMB9 PSMB8 PSMB4
14 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 9.76 PSMB9 PSMB8 PSMB4
15 NIK/NF-kappaB signaling GO:0038061 9.75 PSMB9 PSMB8 PSMB4
16 regulation of hematopoietic stem cell differentiation GO:1902036 9.74 PSMB9 PSMB8 PSMB4
17 negative regulation of G2/M transition of mitotic cell cycle GO:0010972 9.71 PSMB9 PSMB8 PSMB4
18 proteolysis involved in cellular protein catabolic process GO:0051603 9.7 PSMB9 PSMB8 PSMB4
19 regulation of cellular amino acid metabolic process GO:0006521 9.65 PSMB9 PSMB8 PSMB4
20 negative regulation of interleukin-2 production GO:0032703 9.64 NAV3 HAVCR2
21 macrophage activation involved in immune response GO:0002281 9.62 IFNG HAVCR2
22 extrinsic apoptotic signaling pathway GO:0097191 9.58 IFNG FASLG FAS
23 necroptotic signaling pathway GO:0097527 9.55 FASLG FAS
24 proteasomal protein catabolic process GO:0010498 9.54 PSMB9 PSMB8 PSMB4
25 proteasomal ubiquitin-independent protein catabolic process GO:0010499 9.5 PSMB9 PSMB8 PSMB4
26 positive regulation of cellular respiration GO:1901857 9.46 MYC IFNG
27 apoptotic signaling pathway GO:0097190 9.46 FASLG FAS CASP3 BTK
28 MAPK cascade GO:0000165 9.43 PSMB9 PSMB8 PSMB4 NCAM1 MYC BRAF
29 tumor necrosis factor-mediated signaling pathway GO:0033209 9.1 TNFRSF8 PSMB9 PSMB8 PSMB4 FASLG FAS

Molecular functions related to Panniculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.93 TNFRSF8 TIA1 SERPINA1 PSMB9 PSMB8 PSMB4
2 peptidase activity GO:0008233 9.63 PSMB9 PSMB8 PSMB4 OTULIN GZMB CASP3
3 endopeptidase activity GO:0004175 9.43 PSMB9 PSMB8 PSMB4
4 threonine-type endopeptidase activity GO:0004298 8.8 PSMB9 PSMB8 PSMB4
Sources

Sources for Panniculitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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