MCID: PNV001
MIFTS: 51

Panuveitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Panuveitis

MalaCards integrated aliases for Panuveitis:

Name: Panuveitis 12 53 55 44 15 73
Diffuse Uveitis 12 53
Inflammation of the Whole Uveal Tract 53
Total Uveitis 53

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:12030
ICD10 33 H44.11
ICD9CM 35 360.12
MeSH 44 D015864
NCIt 50 C84989
SNOMED-CT 68 75614007
UMLS 73 C0030343

Summaries for Panuveitis

NIH Rare Diseases : 53 Panuveitis is inflammation of all layers of the uvea of the eye, which includes the iris, ciliary body, and choroid. These make up the middle layer of the eye. The condition can also affect the lens, retina, optic nerve, and vitreous, causing reduced vision or blindness. Signs and symptoms may include eye redness and pain; blurring; light sensitivity; decreased vision; and seeing floaters. It can last for a short time or can occur chronically. Severe cases may recur many times. In many cases the specific cause is unknown, but in some cases it occurs in association with other eye conditions, or with another condition or infection that also affects other body parts. Early treatment is needed and may include eye drops to reduce inflammation and pain; and/or oral medications or injections in severe cases.

MalaCards based summary : Panuveitis, also known as diffuse uveitis, is related to vogt-koyanagi-harada disease and multifocal choroiditis. An important gene associated with Panuveitis is UACA (Uveal Autoantigen With Coiled-Coil Domains And Ankyrin Repeats), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and t cells, and related phenotypes are endocrine/exocrine gland and renal/urinary system

Related Diseases for Panuveitis

Diseases in the Panuveitis family:

Infectious Panuveitis

Diseases related to Panuveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 276)
# Related Disease Score Top Affiliating Genes
1 vogt-koyanagi-harada disease 31.5 HLA-A HLA-B HLA-DQB1 HLA-DRB1 IL10 IL17A
2 multifocal choroiditis 31.1 IL10 TNF
3 choroiditis 31.1 IL10 TNF
4 posterior uveitis 30.6 RBP3 SAG TNF
5 punctate inner choroidopathy 30.5 IL10 TNF
6 intermediate uveitis 30.5 HLA-B IL10 TNF
7 vasculitis 30.1 HLA-B TNF TNFRSF1B
8 uveitis 30.1 HLA-B IL10 IL17A RBP3 SAG TNF
9 chorioretinitis 30.1 MRAP RBP3 SAG
10 pulmonary tuberculosis 30.0 HLA-DRB1 IL10 TNF
11 acquired immunodeficiency syndrome 29.9 HLA-B IL10 TNF
12 neurosyphilis 29.8 IL10 IL17A
13 whipple disease 29.8 HLA-DQB1 HLA-DRB1 MRAP
14 multiple sclerosis 29.7 HLA-DQB1 HLA-DRB1 IL10 IL17A TNF
15 arthritis 29.6 HLA-DQB1 HLA-DRB1 IL10 IL17A TNF TNFRSF1B
16 histoplasmosis 29.6 HLA-A HLA-B HLA-DRB1
17 leishmaniasis 29.5 HLA-DQB1 HLA-DRB1 IL10 IL17A TNF
18 anterior uveitis 29.4 HLA-A HLA-B TNF
19 psoriasis 29.4 IL10 IL17A TNF TNFRSF1B
20 herpes zoster 29.4 HLA-A HLA-B IL10
21 rubella 28.9 HLA-A HLA-B HLA-DQB1 HLA-DRB1 IL10 TNF
22 graft-versus-host disease 28.9 HLA-A HLA-B HLA-DQB1 HLA-DRB1 IL10 TNF
23 idiopathic panuveitis 12.2
24 infectious panuveitis 12.2
25 trachoma 10.3 IL10 TNF
26 clonorchiasis 10.3 IL10 TNF
27 mucocutaneous leishmaniasis 10.3 IL10 TNF
28 chronic graft versus host disease 10.3 IL10 TNF
29 cardiac sarcoidosis 10.3 HLA-DQB1 TNF
30 actinic prurigo 10.3 HLA-DRB1 TNF
31 sympathetic ophthalmia 10.3 HLA-DRB1 TNF
32 rheumatoid vasculitis 10.3 HLA-DRB1 TNF
33 discoid lupus erythematosus 10.3 HLA-DRB1 IL10
34 diffuse infiltrative lymphocytosis syndrome 10.3 MRAP TNF
35 diarrhea 1, secretory chloride, congenital 10.3 IL10 MRAP
36 lichen sclerosus 10.3 HLA-DQB1 HLA-DRB1
37 pediatric multiple sclerosis 10.3 HLA-DQB1 HLA-DRB1
38 tropical endomyocardial fibrosis 10.3 IL10 TNF
39 endomyocardial fibrosis 10.3 IL10 TNF
40 limbic encephalitis with lgi1 antibodies 10.3 HLA-DQB1 HLA-DRB1
41 juvenile myasthenia gravis 10.2 HLA-DRB1 IL10
42 periodic fever, familial, autosomal dominant 10.2 TNF TNFRSF1B
43 narcolepsy 2 10.2 HLA-DQB1 HLA-DRB1
44 autoimmune polyglandular syndrome type 3 10.2 HLA-DQB1 HLA-DRB1
45 palladium allergic contact dermatitis 10.2 IL10 IL17A
46 nasopharyngitis 10.2 IL17A TNFRSF1B
47 tungiasis 10.2 IL10 TNF
48 hypersomnia 10.2 HLA-DQB1 HLA-DRB1
49 chronic orbital inflammation 10.2 MRAP TNFRSF1B
50 orbital plasma cell granuloma 10.2 MRAP TNFRSF1B

Graphical network of the top 20 diseases related to Panuveitis:



Diseases related to Panuveitis

Symptoms & Phenotypes for Panuveitis

MGI Mouse Phenotypes related to Panuveitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.76 CYP11B1 ERAP1 HLA-DQB1 IL10 IL17A TNF
2 renal/urinary system MP:0005367 9.43 CYP11B1 ERAP1 HLA-DQB1 IL17A TNFRSF1B UACA
3 respiratory system MP:0005388 9.1 HLA-DQB1 IL10 IL17A TNF TNFRSF1B UACA

Drugs & Therapeutics for Panuveitis

Drugs for Panuveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 161)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
3
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 302-25-0
4
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2921-57-5
5
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 67-73-2 6215
6
Mycophenolic acid Approved Phase 4,Phase 3 24280-93-1 446541
7
Azathioprine Approved Phase 4,Phase 2 446-86-6 2265
8
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-05-2, 1959-05-2 126941
9
Infliximab Approved Phase 4,Phase 3,Phase 1,Phase 2 170277-31-3
10
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-02-2 5743
11
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1177-87-3
12
Ganciclovir Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 82410-32-0 3454
13
Chlorambucil Approved Phase 4 305-03-3 2708
14
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2 6055-19-2, 50-18-0 2907
15
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
16
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
17
Travoprost Approved Phase 4 157283-68-6 5282226
18
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
19
Timolol Approved Phase 4 26839-75-8 33624 5478
20
Latanoprost Approved, Investigational Phase 4 130209-82-4 5311221 5282380
21
Certolizumab pegol Approved Phase 4 428863-50-7
22
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2920-86-7
23
Maleic acid Experimental Phase 4 110-16-7 444266
24 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
25 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
26 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
27 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Prednisolone acetate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Neuroprotective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
32 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
33 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
34 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
35 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
37 Methylprednisolone acetate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
38 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
40 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
41 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
42 Cyclosporins Phase 4,Phase 3
43 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
44 Antitubercular Agents Phase 4,Phase 3
45 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
47 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 BB 1101 Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49
protease inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 164)
# Name Status NCT ID Phase Drugs
1 The Efficacy of Methylprednisolone in the Treatment of Patients With Ocular Involvement in Behcet's Disease Unknown status NCT01306955 Phase 4 methylorednisolone
2 Flucinolone Acetonide Implant for Treating Refractory Ocular Behcet's Disease Unknown status NCT00720928 Phase 4 flucinolone acetonide
3 Multicenter Uveitis Steroid Treatment (MUST) Trial Completed NCT00132691 Phase 4 fluocinolone acetonide intraocular implant;oral corticosteroid with immunosuppressive agents as needed
4 Blood-aqueous Barrier Changes After the Use of Timolol and Prostaglandin Analogues Fixed Combination in Pseudophakic Patients With POAG Completed NCT01978015 Phase 4 travoprost and timolol maleate fixed combination;latanoprost and maleate timolol fixed combination;bimatoprost and timolol maleate fixed combination;dextran and hypromellose
5 Saline vs. Lactated Ringers for Emergency Department IV Fluid Resuscitation Completed NCT03133767 Phase 4 Lactated Ringer Solution;Normal Saline 0.9% Infusion Solution Bag
6 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
7 Efficacy and Safety of H.P. Acthar® Gel in Subjects With Severe Noninfectious Intermediate Uveitis, Posterior Uveitis, or Panuveitis NIPPU Recruiting NCT03656692 Phase 4 Acthar
8 Study of the Effectiveness of Ozurdex for the Control of Uveitis Recruiting NCT02049476 Phase 4 Dexamethasone pellet
9 Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis Recruiting NCT02943057 Phase 4 2% guttae ganciclovir
10 Efficacy and Safety of H.P. ACTHAR GEL in Adults With Retinal Vasculitis Active, not recruiting NCT03066869 Phase 4 H.P. ACTHAR GEL
11 A Study to Assess the Effects of Certolizumab Pegol on the Reduction of Anterior Uveitis (AU) Flares in Axial Spondyloarthritis Subjects With a Documented History of AU Active, not recruiting NCT03020992 Phase 4 Certolizumab Pegol
12 Open Label Study of Acthar SQ Gel Injection in Patients With Active Anterior Uveitis Terminated NCT02769702 Phase 4 Acthar
13 To Compare Intravitreal Clindamycin & Dexamethasone With Classic Treatment of Toxoplasmic Retinochoroiditis Unknown status NCT00372294 Phase 3 pyrimethamine-sulfadiazine + prednisolone;Clindamycin+Dexamethasone
14 A Study of the Long-term Safety and Efficacy of Adalimumab in Subjects With Intermediate-, Posterior-, or Pan-uveitis Completed NCT01148225 Phase 3 adalimumab
15 A Study of LX211 in Clinically Quiescent Non-infectious Intermediate, Anterior and Intermediate, Posterior or Pan-Uveitis Completed NCT00404742 Phase 3 Placebo;LX211;LX211;LX211
16 A Study of LX211 in Active Sight Threatening, Non-infectious Intermediate-, Anterior and Intermediate-, Posterior-, or Pan-Uveitis Completed NCT00404612 Phase 3 Placebo;LX211;LX211;LX211
17 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Severe Uveitis Completed NCT00407056 Phase 3 Difluprednate Ophthalmic Emulsion
18 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis Completed NCT00406887 Phase 3 Difluprednate Ophthalmic Emulsion
19 Phase III Study in Refractory Behcet's Disease Completed NCT00995709 Phase 3 AIN457;AIN457;Placebo
20 Efficacy and Safety of Adalimumab in Subjects With Inactive Uveitis Completed NCT01124838 Phase 3 Adalimumab;Prednisone;Placebo
21 A Multi-center Study to Assess the Efficacy and Safety of LX211 in Active Non-infectious Anterior Uveitis Completed NCT00404885 Phase 3 Placebo;LX211;LX211;LX211
22 Efficacy and Safety of Adalimumab in Patients With Active Uveitis Completed NCT01138657 Phase 3 Prednisone;Placebo
23 A Controlled, Multi-center Study of the Utilization and Safety of the MK II Inserter and the Safety of the FAI Insert in Subjects With Non-infectious Uveitis Affecting the Posterior Segment of the Eye Completed NCT02748512 Phase 3 FAI insert
24 Interferon-alpha2a Versus Cyclosporin A for Severe Ocular Behcet`s Disease (INCYTOB) Completed NCT00167583 Phase 3 Cyclosporin A;Interferon-alpha2a
25 Efficacy and Safety of Voclosporin to Treat Active Noninfectious Uveitis Completed NCT01243983 Phase 3 LX211
26 Suprachoroidal Injection of CLS-TA in Subjects Non-infectious Uveitis Completed NCT03097315 Phase 3
27 Suprachoroidal Injection of CLS-TA in Subjects With Macular Edema Associated With Non-infectious Uveitis Completed NCT02595398 Phase 3 4mg CLS-TA Suprachoriodal Injection;Sham Procedure
28 Safety and Efficacy of Fluocinolone Acetonide Intravitreal Implants Completed NCT00407082 Phase 2, Phase 3 fluocinolone acetonide intravitreal implant;Fluocinolone acetonide 2.1mg
29 Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution in Non-Infectious Anterior Uveitis Completed NCT02517619 Phase 3 Dexamethasone Phosphate Ophthalmic Solution;Prednisolone Acetate Ophthalmic (1%)
30 Safety and Efficacy Study of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution to Treat Non-Infectious Anterior Segment Uveitis Completed NCT01505088 Phase 3 40 mg/mL Dexamethasone phosphate ophthalmic solution;Prednisolone Acetate (1%) Eyedrops;100 mM sodium citrate buffer solution;Placebo Eyedrops
31 Safety and Efficacy of Difluprednate 0.05% for the Treatment of Anterior Uveitis Completed NCT01201798 Phase 3 Difluprednate 0.05% ophthalmic emulsion;Prednisolone acetate 1.0% ophthalmic suspension
32 A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Intermediate or Posterior Uveitis Completed NCT00333814 Phase 2, Phase 3 Dexamethasone;dexamethasone;Sham injection
33 Myfortic for the Treatment of Non-infectious Intermediate Uveitis Completed NCT01092533 Phase 3 Myfortic;Decortin
34 A Study to Evaluate Efficacy and Safety of Infliximab in Participant With Moderate-to-Severe Refractory Intestinal Behcet's Disease Completed NCT02505568 Phase 3 Infliximab
35 Clinical Study of TA-650 in Patients With Behcet's Disease (BD) With Special Lesions Completed NCT01532570 Phase 3 TA-650
36 A Study of Adalimumab in Japanese Subjects With Intestinal Behçet's Disease Completed NCT01243671 Phase 3
37 Efficacy of Humira in Behcet Patients With Arthritis Completed NCT01497717 Phase 3 Adalimumab (Humira)
38 Intravitreal Bevacizumab for Inflammatory Neovascular Membranes Completed NCT00407121 Phase 3 Bevacizumab
39 Randomized, Controlled Trial to Test the Efficacy of Interferon Beta in the Treatment of Intermediate Uveitis Completed NCT00344253 Phase 3 Interferon beta;Methotrexate
40 Interferon α2a Versus Cyclosporine for Refractory Behçet`s Disease Uveitis Recruiting NCT03209219 Phase 3 Interferon Alfa-2A;Cyclosporine Pill
41 SOLACE Trial - A Phase 3 Trial in Subjects With Non-infectious Anterior-uveitis. Recruiting NCT03131154 Phase 3 ADX-102 Ophthalmic Solution (0.5%);Vehicle of ADX-102 Ophthalmic Solution
42 Safety and Efficacy Study of a Fluocinolone Acetonide Intravitreal (FAI) Insert in Subjects With Chronic Non-infectious Posterior Uveitis Active, not recruiting NCT02746991 Phase 3 Sham Injection;FAI Insert
43 Safety and Efficacy of an Injectable Fluocinolone Acetonide Intravitreal Insert Active, not recruiting NCT01694186 Phase 3 FAI insert;Sham injection
44 A Phase 3 Randomized, Double-blind Study to Evaluate the Efficacy and Safety of Apremilast (CC-10004) in Subjects With Active Behcet's Disease Active, not recruiting NCT02307513 Phase 3 Apremilast (CC-10004);Placebo
45 Systemic and Topical Antivirals for Control of Cytomegalovirus Anterior Uveitis: Treatment Outcomes Not yet recruiting NCT03586284 Phase 2, Phase 3 Valganciclovir Hydrochloride;Ganciclovir Sodium;Placebo Oral Tablet;Topical placebo
46 Systemic and Topical Antivirals for Control of Cytomegalovirus Anterior Uveitis Not yet recruiting NCT03576898 Phase 2, Phase 3 Topical ganciclovir versus oral valganciclovir versus placebo
47 Induction Therapy With Anti-TNFα vs Cyclophosphamide in Severe Behçet Disease Not yet recruiting NCT03371095 Phase 3 Infliximab;Cyclophosphamide
48 Safety and Efficacy of AIN457 in Patients With Quiescent Non-infectious Uveitis Terminated NCT01032915 Phase 3 Placebo
49 38 Week Extension Study to CAIN457C2303 Terminated NCT01093846 Phase 3 AIN457;AIN457;Placebo AIN457
50 Safety and Efficacy of AIN457 in Patients With Quiescent Non-infectious Uveitis Terminated NCT01090310 Phase 3 AIN457;Placebo

Search NIH Clinical Center for Panuveitis

Cochrane evidence based reviews: panuveitis

Genetic Tests for Panuveitis

Anatomical Context for Panuveitis

MalaCards organs/tissues related to Panuveitis:

41
Eye, Retina, T Cells, Bone, B Cells, Lung, Skin

Publications for Panuveitis

Articles related to Panuveitis:

(show top 50) (show all 240)
# Title Authors Year
1
Spectral optical coherence tomography findings in an elderly patient with syphilitic bilateral chronic panuveitis. ( 29468221 )
2018
2
Seasonal Hyperacute Panuveitis in Nepal: A Review over 40A Years of Surveillance. ( 29543556 )
2018
3
Challenging treatment of bilateral multiple infection panuveitis in HIV/AIDS patients. ( 29977825 )
2018
4
Pseudo-panuveitis masquerade syndrome associated with an orbital and systemic MALT-type B-cell lymphoma. ( 29567022 )
2018
5
Long-term retention rates of adalimumab and infliximab in non-infectious intermediate, posterior, and panuveitis. ( 29611087 )
2018
6
Two cases of cytomegalovirus panuveitis in immunocompetent patients. ( 29780935 )
2018
7
Sarcoidosis presenting as Wallenberg syndrome and panuveitis. ( 29977748 )
2018
8
Progressive Depigmentation in a Patient with Panuveitis and Meningitis. ( 29457006 )
2018
9
Varicella-zoster virus necrotising retinitis, retinal vasculitis and panuveitis following uncomplicated chickenpox in an immunocompetent child. ( 29622711 )
2018
10
Comparative efficacy between adalimumab and infliximab in the treatment of non-infectious intermediate uveitis, posterior uveitis, and panuveitis: a retrospective observational study of 107 patients. ( 30099655 )
2018
11
Severe panuveitis with relapsing polychondritis. ( 30050999 )
2018
12
Topiramate-induced acute angle closure with severe panuveitis: A challenging case report. ( 30127167 )
2018
13
Bilateral Panuveitis and Keratitis as First Presentation of Relapsing Polychondritis. ( 30193073 )
2018
14
Oral corticosteroid exposure and increased risk of related complications in patients with noninfectious intermediate, posterior, or panuveitis: Real-world data analysis. ( 30199301 )
2018
15
The rescue effect of adalimumab in the treatment of refractory pediatric panuveitis complicated with steroid-induced glaucoma. ( 30294530 )
2018
16
Clinical Characteristics and Treatment of 308 Panuveitis Patients over 10 Years: Results from the KKESH Uveitis Survey Study Group. ( 30303435 )
2018
17
Recurrent grade 4 panuveitis with serous retinal detachment related to nivolumab treatment in a patient with metastatic renal cell carcinoma. ( 30311026 )
2018
18
Corticosteroid-Related Adverse Events Systematically Increase with Corticosteroid Dose in Noninfectious Intermediate, Posterior, or Panuveitis: Post Hoc Analyses from the VISUAL-1 and VISUAL-2 Trials. ( 28689898 )
2017
19
Morphometric features on enhanced depth imaging optical coherence tomography scans in idiopathic posterior uveitis or panuveitis. ( 28585111 )
2017
20
Acute hypotony maculopathy following the initiation of a topical aqueous suppressant in a patient with a history of panuveitis without prior filtering surgery. ( 29260088 )
2017
21
Severe panuveitis in neuro-BehAset's disease in Malaysia: a case series. ( 28223848 )
2017
22
A systematic review and economic evaluation of adalimumab and dexamethasone for treating non-infectious intermediate uveitis, posterior uveitis or panuveitis in adults. ( 29183563 )
2017
23
Association Between Long-Lasting Intravitreous Fluocinolone Acetonide Implant vs Systemic Anti-inflammatory Therapy and Visual Acuity at 7 Years Among Patients With Intermediate, Posterior, or Panuveitis. ( 28477440 )
2017
24
Quality-of-Life Outcomes From a Randomized Clinical Trial Comparing Antimetabolites for Intermediate, Posterior, and Panuveitis. ( 28414043 )
2017
25
Re: Jaffe etA al.: Injectable fluocinolone acetonide long-acting implant for noninfectious intermediate uveitis, posterior uveitis, and panuveitis: 2-year results (Ophthalmology. 2016;123:1940-1948). ( 28734339 )
2017
26
Panuveitis simulating ocular BehAset's in cases of chronic myelogenous leukaemia in remission. ( 29170182 )
2017
27
Multiple myeloma masquerading as panuveitis in a middle-aged woman. ( 29308780 )
2017
28
Re: Jaffe etA al.: Injectable fluocinolone acetonide long-acting implant for noninfectious intermediate uveitis, posterior uveitis, and panuveitis: two-year results (Ophthalmology. 2016;123:1940-1948). ( 28335961 )
2017
29
IgG4-related disease presenting as panuveitis without scleral involvement. ( 28243891 )
2017
30
Multifocal Choroiditis and Panuveitis - difficulties in diagnosis and treatment. ( 29516050 )
2017
31
Panuveitis-like reaction following encircling laser retinopexy/cerclage in a 21-year-old male. ( 29038978 )
2017
32
Toxoplasma gondii-Associated Bilateral Panuveitis and Encephalitis after Bone Marrow Transplantation. ( 29156468 )
2017
33
Ocular Autoimmune Systemic Inflammatory Infectious Study - Report 3: Posterior and Panuveitis. ( 28991501 )
2017
34
Enhanced depth imaging optical coherence tomography in patients with different phases of Behcet's panuveitis. ( 28237149 )
2017
35
Effect of Adalimumab on Visual Functioning in Patients With Noninfectious Intermediate Uveitis, Posterior Uveitis, and Panuveitis in the VISUAL-1 and VISUAL-2 Trials. ( 28426849 )
2017
36
Dress syndrome and bilateral panuveitis caused by strontium ranelate. ( 28662886 )
2017
37
Vision-threatening bilateral panuveitis and TRAPS in a child: an uncommon association. ( 29256170 )
2017
38
Choroidal Vascularity Index (CVI)--A Novel Optical Coherence Tomography Parameter for Monitoring Patients with Panuveitis? ( 26751702 )
2016
39
Multiple Sclerosis and Panuveitis: A Rare Association. ( 28360778 )
2016
40
TARANTULA HAIR ASSOCIATED PANUVEITIS TREATED WITH SUSTAINED-RELEASE INTRAVITREAL DEXAMETHASONE IMPLANT. ( 27472515 )
2016
41
Canine panuveitis: a retrospective evaluation of 55 cases (2000-2015). ( 27734587 )
2016
42
Direct and indirect resource use, healthcare costs and work force absence in patients with non-infectious intermediate, posterior or panuveitis. ( 26932535 )
2016
43
Risk of Ocular Complications in Patients with Noninfectious Intermediate Uveitis, Posterior Uveitis, or Panuveitis. ( 26712559 )
2016
44
Long-term Management of Panuveitis and Iris Heterochromia in an Ebola Survivor. ( 27594198 )
2016
45
Idiopathic Orbital Inflammation Presenting with Bilateral Panuveitis. ( 27112170 )
2016
46
A Hemophagocytic Lymphohistiocytosis Patient that Presented With Unilateral Panuveitis. ( 26731243 )
2016
47
Zika Virus Infection in Mice Causes Panuveitis with Shedding of Virus in Tears. ( 27612415 )
2016
48
Dengue Fever-Associated Maculopathy and Panuveitis in Australia. ( 28078150 )
2016
49
A Case of Severe Panuveitis Associated with Psoriasis Vulgaris Successfully Treated with Infliximab. ( 27239187 )
2016
50
GRAFT-VERSUS-HOST DISEASE PANUVEITIS AND BILATERAL SEROUS DETACHMENTS: MULTIMODAL IMAGING ANALYSIS. ( 27571426 )
2016

Variations for Panuveitis

Expression for Panuveitis

Search GEO for disease gene expression data for Panuveitis.

Pathways for Panuveitis

Pathways related to Panuveitis according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.86 ERAP1 HLA-A HLA-B HLA-DQB1 HLA-DRB1 IL10
2
Show member pathways
12.87 HLA-A HLA-B HLA-DQB1 HLA-DRB1 IL10 IL17A
3
Show member pathways
12.66 HLA-A HLA-B HLA-DQB1 HLA-DRB1 TNF
4
Show member pathways
12.48 HLA-DQB1 HLA-DRB1 IL10 TNF TNFRSF1B
5 12.43 IL10 IL17A TNF TNFRSF1B
6
Show member pathways
12.41 HLA-DQB1 HLA-DRB1 IL10 IL17A TNF
7
Show member pathways
12.4 HLA-A HLA-B HLA-DQB1 HLA-DRB1
8
Show member pathways
12.13 HLA-DQB1 HLA-DRB1 IL10 TNF
9 12.13 HLA-A HLA-B HLA-DQB1 HLA-DRB1 TNF
10 12.09 HLA-DQB1 HLA-DRB1 IL10 TNF
11
Show member pathways
12.06 HLA-A HLA-B IL10 IL17A TNF
12 11.99 HLA-A HLA-B HLA-DQB1 HLA-DRB1
13
Show member pathways
11.96 HLA-A HLA-B HLA-DQB1 HLA-DRB1 IL10 IL17A
14 11.95 HLA-A HLA-B HLA-DQB1 HLA-DRB1
15
Show member pathways
11.91 IL10 IL17A TNF
16 11.76 HLA-DQB1 HLA-DRB1 TNF
17 11.76 IL10 IL17A TNF TNFRSF1B
18 11.67 IL10 IL17A TNF
19 11.66 HLA-A HLA-B HLA-DQB1 HLA-DRB1 TNF
20 11.61 IL10 IL17A TNF
21 11.51 HLA-DQB1 HLA-DRB1 IL17A TNF
22 11.49 HLA-DQB1 HLA-DRB1 IL10
23 11.41 IL10 TNF TNFRSF1B
24 11.07 HLA-DRB1 IL10 TNF
25 10.94 ERAP1 HLA-A HLA-B

GO Terms for Panuveitis

Cellular components related to Panuveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II protein complex GO:0042613 9.26 HLA-DQB1 HLA-DRB1
2 ER to Golgi transport vesicle membrane GO:0012507 9.26 HLA-A HLA-B HLA-DQB1 HLA-DRB1
3 MHC class I protein complex GO:0042612 9.16 HLA-A HLA-B
4 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.92 HLA-A HLA-B HLA-DQB1 HLA-DRB1

Biological processes related to Panuveitis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.88 IL10 IL17A TNF TNFRSF1B
2 cytokine-mediated signaling pathway GO:0019221 9.83 IL10 IL17A TNF TNFRSF1B
3 positive regulation of T cell mediated cytotoxicity GO:0001916 9.59 HLA-A HLA-B
4 positive regulation of osteoclast differentiation GO:0045672 9.58 IL17A TNF
5 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.57 TNF TNFRSF1B
6 negative regulation of growth of symbiont in host GO:0044130 9.56 IL10 TNF
7 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.55 IL10 TNF
8 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.54 HLA-DQB1 HLA-DRB1
9 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.51 HLA-A HLA-B
10 endothelial cell apoptotic process GO:0072577 9.49 IL10 TNF
11 antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 9.48 HLA-A HLA-B
12 negative regulation of cytokine secretion involved in immune response GO:0002740 9.46 IL10 TNF
13 interferon-gamma-mediated signaling pathway GO:0060333 9.46 HLA-A HLA-B HLA-DQB1 HLA-DRB1
14 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.43 HLA-DQB1 HLA-DRB1
15 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.43 ERAP1 HLA-A HLA-B
16 protection from natural killer cell mediated cytotoxicity GO:0042270 9.4 HLA-A HLA-B
17 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.37 HLA-DQB1 HLA-DRB1
18 receptor biosynthetic process GO:0032800 9.32 IL10 TNF
19 immune response GO:0006955 9.28 CYP11B1 HLA-A HLA-B HLA-DQB1 HLA-DRB1 IL10
20 antigen processing and presentation GO:0019882 9.26 HLA-A HLA-B HLA-DQB1 HLA-DRB1

Molecular functions related to Panuveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 8.96 HLA-DQB1 HLA-DRB1
2 peptide antigen binding GO:0042605 8.92 HLA-A HLA-B HLA-DQB1 HLA-DRB1

Sources for Panuveitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
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54 NINDS
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57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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