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MCID: PPL018
MIFTS: 49

Papillary Adenocarcinoma

Categories: Cancer diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Papillary Adenocarcinoma

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MalaCards integrated aliases for Papillary Adenocarcinoma:

Name: Papillary Adenocarcinoma 12 15 73
Infiltrating and Papillary Adenocarcinoma 12
Infiltrating Papillary Adenocarcinoma 12
Adenocarcinoma, Papillary 44
Adenocarcinoma Papillary 55

Classifications:

MalaCards categories:
Global: Cancer diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3112
MeSH 44 D000231
NCIt 50 C2853 C7438
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Summaries for Papillary Adenocarcinoma

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Disease Ontology : 12 An adenocarcinoma that derives from epithelial cells originating in glandular tissue, which form complex papillary structures and exhibit compressive, destructive growth that replaces the normal tissue.

MalaCards based summary : Papillary Adenocarcinoma, also known as infiltrating and papillary adenocarcinoma, is related to aggressive digital papillary adenocarcinoma and gastric papillary adenocarcinoma. An important gene associated with Papillary Adenocarcinoma is NKX2-1 (NK2 Homeobox 1), and among its related pathways/superpathways are Development EGFR signaling pathway and Cytoskeletal Signaling. The drugs Bevacizumab and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lung and cervix, and related phenotypes are Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance and cellular

Wikipedia : 76 Papillary adenocarcinoma is a histological form of lung cancer that is diagnosed when the malignant... more...

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Related Diseases for Papillary Adenocarcinoma

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Diseases related to Papillary Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 366)
# Related Disease Score Top Affiliating Genes
1 aggressive digital papillary adenocarcinoma 34.2 CEACAM5 MUC1
2 gastric papillary adenocarcinoma 33.9 ERBB2 TP53
3 renal cell carcinoma, papillary, 1 32.2 ERBB2 KRT7 TP53
4 papillary serous adenocarcinoma 31.1 KRT7 NKX2-1 PGR TP53
5 papillary adenoma 30.4 KRT7 NKX2-1 VIM
6 pulmonary sclerosing hemangioma 30.4 KRT7 NKX2-1
7 sclerosing hemangioma 30.2 KRT7 MUC1 NKX2-1
8 adenocarcinoma 30.1 CDH1 ERBB2 MUC1 TP53
9 thymus adenocarcinoma 30.0 CEACAM5 KRT7
10 pseudo-meigs syndrome 29.7 CDH1 MUC16
11 endometrial adenocarcinoma 28.8 ERBB2 KRT7 PGR TP53
12 squamous cell carcinoma 28.7 CDH1 ERBB2 MUC1 TP53
13 microinvasive gastric cancer 28.4 CDH1 CEACAM5 MUC2
14 transitional cell carcinoma 28.2 CDH1 ERBB2 KRT7 TP53
15 cholecystitis 28.1 CDH1 MUC1 MUC2 TP53
16 ovarian cancer 1 27.1 CDH1 CEACAM5 ERBB2 KRT7 TP53
17 gastric cancer 26.6 CDH1 CEACAM5 ERBB2 MUC2 TP53
18 cystadenocarcinoma 25.4 CEACAM5 ERBB2 KRT7 MUC1 MUC16 MUC2
19 ovarian cancer 25.3 CDH1 ERBB2 KRT7 MUC1 MUC16 MUC2
20 eccrine papillary adenocarcinoma 12.2
21 fallopian tube papillary adenocarcinoma 12.1
22 lung papillary adenocarcinoma 12.1
23 peritoneal serous papillary adenocarcinoma 12.1
24 nasopharyngeal carcinoma 3 11.0
25 malignant peritoneal mesothelioma 10.9 MUC1 VIM
26 papillary tumor of the pineal region 10.9 MUC1 VIM
27 ossifying fibromyxoid tumor 10.8 MUC1 VIM
28 fibrous meningioma 10.8 MUC1 VIM
29 chordoid meningioma 10.8 MUC1 VIM
30 syringocystadenoma papilliferum 10.8 MUC1 VIM
31 middle ear adenoma 10.8 KRT7 MUC1
32 eccrine porocarcinoma 10.8 MUC1 VIM
33 myxopapillary ependymoma 10.8 MUC1 VIM
34 ovarian germ cell teratoma 10.8 KRT7 NKX2-1
35 nephrogenic adenoma 10.8 KRT7 MUC1
36 syringoma 10.8 MUC1 VIM
37 lung acinar adenocarcinoma 10.8 KRT7 NKX2-1
38 small cell carcinoma of the bladder 10.8 KRT7 NKX2-1
39 ovarian germ cell cancer 10.8 KRT7 NKX2-1
40 adenomyoma 10.8 KRT7 MUC1
41 pleomorphic liposarcoma 10.7 MUC1 VIM
42 desmoplastic small round cell tumor 10.7 MUC1 VIM
43 anaplastic ependymoma 10.7 MUC1 VIM
44 bronchiolo-alveolar adenocarcinoma 10.7 KRT7 NKX2-1
45 medulloepithelioma 10.7 KRT7 VIM
46 sarcomatoid mesothelioma 10.7 MUC1 NKX2-1
47 reticulum cell sarcoma 10.7 MUC1 VIM
48 metanephric adenoma 10.7 KRT7 VIM
49 well-differentiated liposarcoma 10.7 KRT7 MUC1
50 lymphangiomatosis 10.7 PGR VIM

Graphical network of the top 20 diseases related to Papillary Adenocarcinoma:



Diseases related to Papillary Adenocarcinoma
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Symptoms & Phenotypes for Papillary Adenocarcinoma

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GenomeRNAi Phenotypes related to Papillary Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 8.92 ERBB2 MST1R MUC1 VIM

MGI Mouse Phenotypes related to Papillary Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.92 TP53 ERBB2 KRT7 VIM MUC2 NKX2-1
2 cardiovascular system MP:0005385 9.91 TP53 ERBB2 VIM MUC2 NKX2-1 PGR
3 homeostasis/metabolism MP:0005376 9.81 TP53 ERBB2 KRT7 VIM MST1R MUC2
4 endocrine/exocrine gland MP:0005379 9.8 TP53 ERBB2 MST1R MUC2 NKX2-1 PGR
5 neoplasm MP:0002006 9.43 MUC2 NKX2-1 PGR CDH1 TP53 ERBB2
6 reproductive system MP:0005389 9.17 ERBB2 VIM MST1R NKX2-1 PGR CDH1
Sources

Drugs & Therapeutics for Papillary Adenocarcinoma

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Drugs for Papillary Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 2 216974-75-3
2
Everolimus Approved Phase 2 159351-69-6 6442177
3
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
4
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
5
nivolumab Approved Phase 2 946414-94-4
6
Letrozole Approved, Investigational Phase 2 112809-51-5 3902
7
Gemcitabine Approved Phase 2 95058-81-4 60750
8
Olaparib Approved Phase 1, Phase 2 763113-22-0 23725625
9
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
10
Cediranib Investigational Phase 1, Phase 2 288383-20-0 9933475
11
Maleic acid Experimental Phase 1, Phase 2 110-16-7 444266
12
Atrasentan Investigational Phase 2 173937-91-2, 195733-43-8 159594
13
Doxil Approved June 1999 Phase 2 31703
14 Angiogenesis Inhibitors Phase 2
15 Angiogenesis Modulating Agents Phase 2
16 Anti-Bacterial Agents Phase 2
17 Antibiotics, Antitubercular Phase 2
18 Antibodies Phase 2
19 Antibodies, Monoclonal Phase 2
20 Antifungal Agents Phase 2
21 Anti-Infective Agents Phase 2
22 Endothelial Growth Factors Phase 2
23 Immunoglobulin G Phase 2
24 Immunoglobulins Phase 2
25 Immunosuppressive Agents Phase 2
26 Liver Extracts Phase 2
27 Mitogens Phase 2
28 Aromatase Inhibitors Phase 2
29 Estrogen Antagonists Phase 2
30 Estrogens Phase 2
31 Hormone Antagonists Phase 2
32 Hormones Phase 2
33 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
34 Steroid Synthesis Inhibitors Phase 2
35 Antimetabolites Phase 2
36 Antimetabolites, Antineoplastic Phase 2
37 Antiviral Agents Phase 2
38 Poly(ADP-ribose) Polymerase Inhibitors Phase 1, Phase 2
39 Protein Kinase Inhibitors Phase 1, Phase 2
40 Endothelin Receptor Antagonists Phase 2
41 taxane Phase 2
42 Topoisomerase Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Temsirolimus and Bevacizumab in Treating Patients With Advanced Endometrial, Ovarian, Liver, Carcinoid, or Islet Cell Cancer Completed NCT01010126 Phase 2 Temsirolimus
2 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2
3 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
4 Everolimus and Letrozole in Treating Patients With Recurrent Hormone Receptor Positive Ovarian, Fallopian Tube, or Primary Peritoneal Cavity Cancer Active, not recruiting NCT02283658 Phase 2 Everolimus;Letrozole
5 Gemcitabine Hydrochloride With or Without WEE1 Inhibitor MK-1775 in Treating Patients With Recurrent Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Active, not recruiting NCT02101775 Phase 2 Adavosertib;Gemcitabine Hydrochloride
6 Cediranib Maleate and Olaparib in Treating Patients With Recurrent Ovarian, Fallopian Tube, or Peritoneal Cancer or Recurrent Triple-Negative Breast Cancer Active, not recruiting NCT01116648 Phase 1, Phase 2 Cediranib Maleate;Olaparib
7 Ph II Atrasentan + DOXIL in Recurrent Ovarian/Fallopian/Peritoneal Serous Papillary Adenocarcinoma Terminated NCT00653328 Phase 2 atrasentan hydrochloride;doxil
8 Research Study in Patients With Advanced Ovarian Epithelial Cancer Withdrawn NCT00053235

Search NIH Clinical Center for Papillary Adenocarcinoma

Cochrane evidence based reviews: adenocarcinoma, papillary

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Genetic Tests for Papillary Adenocarcinoma

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Anatomical Context for Papillary Adenocarcinoma

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MalaCards organs/tissues related to Papillary Adenocarcinoma:

41
Thyroid, Lung, Cervix, Ovary, Liver, Lymph Node, Pancreas
Sources

Publications for Papillary Adenocarcinoma

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Articles related to Papillary Adenocarcinoma:

(show top 50) (show all 366)
# Title Authors Year
1
Papillary Adenocarcinoma in a Gastric Duplication Cyst. ( 29563742 )
2018
2
Endonasal endoscopic nasopharyngectomy for the treatment of nasopharyngeal papillary adenocarcinoma: Report of a rare case. ( 29287881 )
2018
3
Nasopharyngeal Papillary Adenocarcinoma as a Second Head and Neck Malignancy. ( 29923095 )
2018
4
Clinicopathologic Characteristics of Thyroid-like Low-grade Nasopharyngeal Papillary Adenocarcinoma: A Case Report. ( 29494399 )
2018
5
The So-Called Aggressive Digital Papillary Adenocarcinoma Is Epithelial-Myoepithelial Carcinoma. ( 29384814 )
2018
6
Pulmonary papillary adenocarcinoma with<i>Aspergillus versicolor</i>infection in a dog. ( 29234587 )
2018
7
Aggressive Digital Papillary Adenocarcinoma: Population-Based Analysis of Incidence, Demographics, Treatment, and Outcomes. ( 29578881 )
2018
8
Aggressive digital papillary adenocarcinoma: A clinicopathological study of 19 cases. ( 28495496 )
2017
9
Response to: Cutaneous papillary adenocarcinoma in situ. ( 28299799 )
2017
10
Endoscopic submucosal dissection for papillary adenocarcinoma of the stomach: is it really safe? ( 28271420 )
2017
11
Lymphovascular invasion and lymph node metastasis rates in papillary adenocarcinoma of the stomach: implications for endoscopic resection. ( 29280035 )
2017
12
Primary thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: A case report and literature review. ( 29381996 )
2017
13
Aggressive Digital Papillary Adenocarcinoma of the Hand Presenting as a Felon. ( 28421154 )
2017
14
Clinicopathological and molecular stability and methylation analyses of gastric papillary adenocarcinoma. ( 28830689 )
2017
15
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma with squamous differentiation: A novel histological finding. ( 28601658 )
2017
16
Primary papillary adenocarcinoma of the lung: Report of two cases. ( 28474664 )
2017
17
Masson's Tumor Masquerading as a Papillary Adenocarcinoma on Fine Needle Aspiration Cytology: A Case Report. ( 28272657 )
2017
18
Mohs Micrographic Surgery as a Digit-Sparing Treatment for Aggressive Digital Papillary Adenocarcinoma. ( 28291063 )
2017
19
Highly variable clinical feature and course of aggressive digital papillary adenocarcinoma. ( 29194742 )
2017
20
Aggressive digital papillary adenocarcinoma: treatment with Mohs micrographic surgery and an update of the literature. ( 28832985 )
2017
21
An Alpha Fetoprotein Producing Gastric Tumor with Yolk Sac, Hepatoid and Papillary Adenocarcinoma Components. ( 29207718 )
2017
22
Nasopharyngeal papillary adenocarcinoma. ( 29236265 )
2017
23
Cutaneous papillary adenocarcinoma in situ. ( 28164358 )
2017
24
Cronkhite-Canada Syndrome with a Major Duodenal Papillary Adenocarcinoma. ( 28924129 )
2017
25
Clinicopathological Features of Low-Grade Thyroid-Like Nasopharyngeal Papillary Adenocarcinoma. ( 27384157 )
2016
26
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: A case report. ( 28105348 )
2016
27
Low-grade papillary adenocarcinoma of nasopharynx with expression of thyroid transcription factor-1: Case report and review of literature. ( 27721286 )
2016
28
A retrospective review of 11 cases of villoglandular papillary adenocarcinoma of the uterine cervix and a review of the literature. ( 26998142 )
2016
29
Low-grade nasopharyngeal papillary adenocarcinoma: a case report and review of the literature. ( 27274289 )
2016
30
Malignant transformation of alveolar adenoma to papillary adenocarcinoma: a case report. ( 27162700 )
2016
31
Aggressive papillary adenocarcinoma on atypical localization: A unique case report. ( 27428196 )
2016
32
Aggressive Digital Papillary Adenocarcinoma With Multiple Organ Metastases: A Case Report and Review of the Literature. ( 27870729 )
2016
33
Treatment of endolymphatic sac tumour (Papillary adenocarcinoma) of the temporal bone. ( 27330425 )
2016
34
Papillary adenocarcinoma with tentacular processes (with video). ( 27302875 )
2016
35
Villoglandular papillary adenocarcinoma: case report. ( 28293348 )
2016
36
Papillary adnexal neoplasm (Aggressive digital papillary adenocarcinoma) on the ankle of a 15 year old girl: case report and review of literature from a pediatric perspective. ( 27535353 )
2016
37
Role of Radiotherapy in Aggressive Digital Papillary Adenocarcinoma. ( 27098633 )
2016
38
Papillary adenocarcinoma of the renal pelvis with renal calculus: A rare case report. ( 27123287 )
2016
39
An unexpected digital papillary adenocarcinoma of the thumb. ( 27990456 )
2016
40
Metastatic Papillary Adenocarcinoma in a 22-Year-Old: Is Her History of Mayer-Rokitansky-KA1ster-Hauser Syndrome Causative or Incidental? ( 27987200 )
2016
41
Villoglandular papillary adenocarcinoma of the uterine cervix: A report of 4 cases and a review of the literature. ( 26870293 )
2016
42
Aggressive Digital Papillary Adenocarcinoma: Case Report of a Positive Sentinel Lymph Node and Discussion of Utility of Sentinel Lymph Node Biopsy. ( 25954845 )
2015
43
Aggressive Digital Papillary Adenocarcinoma. ( 26576210 )
2015
44
&amp;quot;Apocrine Hidrocystoma and Cystadenoma&amp;quot;-like Tumor of the Digits or Toes: A Potential Diagnostic Pitfall of Digital Papillary Adenocarcinoma. ( 26523544 )
2015
45
Low-grade papillary adenocarcinoma of minor salivary glands in pregnancy. ( 26960505 )
2015
46
Is endoscopic submucosal dissection safe for papillary adenocarcinoma of the stomach? ( 25852280 )
2015
47
Spreading Patterns, Prognostic factors and Treatment Outcomes of Nasopharyngeal Papillary Adenocarcinoma and Salivary Gland-type Carcinomas. ( 26118586 )
2015
48
Right visual loss due to choroidal metastasis of a papillary adenocarcinoma of the lung: a case report. ( 26662155 )
2015
49
Endoscopic ultrasonography-guided drainage of infected intracystic papillary adenocarcinoma of the liver. ( 26412329 )
2015
50
Aggressive digital papillary adenocarcinoma - a rare malignant tumor of the sweat glands: two case reports and a review of the literature. ( 25848311 )
2015
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Variations for Papillary Adenocarcinoma

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Expression for Papillary Adenocarcinoma

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Search GEO for disease gene expression data for Papillary Adenocarcinoma.
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Pathways for Papillary Adenocarcinoma

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Pathways related to Papillary Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Development EGFR signaling pathway 22
Show member pathways
 12.11 CDH1 ERBB2 MUC1 TP53
2
Cytoskeletal Signaling 4
12.05 CDH1 KRT7 MUC1 VIM
3
Gastric cancer 37
Show member pathways
 12.02 CDH1 ERBB2 MUC2 PGR TP53
4
O-linked glycosylation 66
Show member pathways
 11.93 MUC1 MUC16 MUC2
5
Diseases of glycosylation 66
Show member pathways
 11.82 MUC1 MUC16 MUC2
6
Adhesion 4
11.7 CDH1 CEACAM5 MUC1
7
Interleukin-4 and 13 signaling 66
11.64 MUC1 TP53 VIM
8
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) 66
Show member pathways
 11.58 MUC1 MUC16 MUC2
9
Bladder cancer 37 1
11.2 CDH1 ERBB2 TP53
10
TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition 1
10.71 CDH1 VIM
11
a6b1 and a6b4 Integrin signaling 1
10.29 CDH1 ERBB2 MST1R
Sources

GO Terms for Papillary Adenocarcinoma

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Cellular components related to Papillary Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.8 MUC1 MUC16 MUC2

Biological processes related to Papillary Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.56 ERBB2 NKX2-1 TP53 VIM
2 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.16 MUC1 TP53
3 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.13 MUC1 MUC16 MUC2
4 O-glycan processing GO:0016266 8.8 MUC1 MUC16 MUC2

Molecular functions related to Papillary Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.26 MST1R NKX2-1 PGR TP53
2 identical protein binding GO:0042802 9.1 CDH1 CEACAM5 ERBB2 PGR TP53 VIM
Sources

Sources for Papillary Adenocarcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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