MCID: PPL016
MIFTS: 32

Papillary Adenofibroma

Categories: Cancer diseases
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Aliases & Classifications for Papillary Adenofibroma

MalaCards integrated aliases for Papillary Adenofibroma:

Name: Papillary Adenofibroma 11 14 71

Classifications:



External Ids:

Disease Ontology 11 DOID:5479
NCIt 49 C8986
SNOMED-CT 68 2962009
UMLS 71 C1377850

Summaries for Papillary Adenofibroma

Disease Ontology: 11 An adenofibroma that is characterized by finger-like projections on histology.

MalaCards based summary: Papillary Adenofibroma is related to adenofibroma and carcinosarcoma. An important gene associated with Papillary Adenofibroma is SLX4 (SLX4 Structure-Specific Endonuclease Subunit), and among its related pathways/superpathways are Homologous DNA Pairing and Strand Exchange and DNA repair pathways, full network. Affiliated tissues include cervix, uterus and ovary, and related phenotypes are Increased shRNA abundance (Z-score > 2) and homeostasis/metabolism

Related Diseases for Papillary Adenofibroma

Diseases related to Papillary Adenofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 225)
# Related Disease Score Top Affiliating Genes
1 adenofibroma 30.3 WT1 PAX8 NAPSA CALB2 ARID1A
2 carcinosarcoma 29.8 WT1 PTEN PAX8 CDKN2A CALB2
3 mixed cell type cancer 29.3 WT1 PTEN POLE PAX8 CDKN2A CALB2
4 cervical clear cell adenocarcinoma 10.3 NAPSA CDKN2A
5 endometrial mucinous adenocarcinoma 10.3 GNAS CDKN2A
6 vulvar seborrheic keratosis 10.3 PTEN CDKN2A
7 gastritis, familial giant hypertrophic 10.3 TFF2 MUC6
8 solid adenocarcinoma with mucin production 10.3 NAPSA MUC6
9 endometrial squamous cell carcinoma 10.3 PAX8 CDKN2A
10 ovarian endodermal sinus tumor 10.3 PAX8 NAPSA
11 urethral diverticulum 10.3 PAX8 NAPSA
12 ovarian primitive germ cell tumor 10.3 PAX8 NAPSA
13 adenocarcinoma in situ 10.2 NAPSA MUC6 CDKN2A
14 rete testis adenoma 10.2 PAX8 CALB2
15 endometrial clear cell adenocarcinoma 10.2 POLE NAPSA HNF1B
16 rete testis neoplasm 10.2 PAX8 CALB2
17 rete testis adenocarcinoma 10.2 PAX8 CALB2
18 sinonasal undifferentiated carcinoma 10.2 SMARCA4 CDKN2A
19 nephrogenic adenoma of the urethra 10.2 PAX8 CALB2
20 gastrointestinal adenoma 10.2 TFF2 MSH6
21 fallopian tube squamous cell carcinoma 10.2 WT1 CDKN2A
22 respiratory system benign neoplasm 10.2 PTEN NAPSA CDKN2A
23 gallbladder signet ring cell adenocarcinoma 10.2 PAX8 CALB2
24 pleomorphic carcinoma 10.2 NAPSA CALB2
25 uterus perivascular epithelioid cell tumor 10.2 PAX8 CALB2
26 ovarian germ cell teratoma 10.2 PAX8 CALB2
27 cervix endometriosis 10.2 POLE CDKN2A CALB2
28 ovarian serous adenofibroma 10.2 PAX8 CALB2
29 appendix disease 10.2 PAX8 MUC6 GNAS
30 papillary adenoma 10.2 PAX8 NAPSA
31 appendix cancer 10.2 PAX8 MUC6 GNAS
32 large cell carcinoma with rhabdoid phenotype 10.2 SMARCA4 CALB2
33 ovarian wilms' cancer 10.1 WT1 CALB2
34 cervical adenoma malignum 10.1 STK11 MUC6
35 small-cell carcinoma of the ovary of hypercalcemic type 10.1 SMARCA4 ARID1A
36 fallopian tube carcinosarcoma 10.1 WT1 CALB2
37 appendix adenocarcinoma 10.1 MSH6 GNAS
38 lymphohistiocytoid mesothelioma 10.1 PAX8 CDKN2A CALB2
39 ovarian mesodermal adenosarcoma 10.1 WT1 PAX8
40 thymus large cell carcinoma 10.1 SMARCA4 PAX8
41 epididymal neoplasm 10.1 WT1 CALB2
42 malignant biphasic mesothelioma 10.1 WT1 CALB2
43 urethral benign neoplasm 10.1 PAX8 CALB2
44 pancreatic serous cystadenoma 10.1 STK11 MUC6
45 mesenchymal cell neoplasm 10.1
46 hematocele of tunica vaginalis testis 10.1 WT1 CALB2
47 pericardial mesothelioma 10.1 WT1 CALB2
48 ovarian mixed germ cell neoplasm 10.1 WT1 PAX8
49 pulmonary large cell neuroendocrine carcinoma 10.1 STK11 NAPSA
50 pericardium cancer 10.1 WT1 CALB2

Graphical network of the top 20 diseases related to Papillary Adenofibroma:



Diseases related to Papillary Adenofibroma

Symptoms & Phenotypes for Papillary Adenofibroma

GenomeRNAi Phenotypes related to Papillary Adenofibroma according to GeneCards Suite gene sharing:

25 (show all 32)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.9 WT1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.9 NAPSA
3 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.9 MSH2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-119 9.9 HNF1B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.9 WT1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-14 9.9 MSH2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-145 9.9 WT1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.9 MSH2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.9 WT1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.9 ARID1B
11 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.9 PAX8
12 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.9 ARID1A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.9 ARID1A MSH2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.9 ARID1A
15 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.9 NAPSA
16 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.9 ARID1A
17 Increased shRNA abundance (Z-score > 2) GR00366-A-203 9.9 NAPSA
18 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.9 NAPSA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-213 9.9 ARID1A
20 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.9 MSH2 WT1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-26 9.9 NAPSA
22 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.9 WT1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.9 ARID1A WT1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.9 WT1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-5 9.9 HNF1B
26 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.9 NAPSA
27 Increased shRNA abundance (Z-score > 2) GR00366-A-53 9.9 MSH2
28 Increased shRNA abundance (Z-score > 2) GR00366-A-55 9.9 NAPSA
29 Increased shRNA abundance (Z-score > 2) GR00366-A-72 9.9 ARID1B
30 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.9 ARID1A
31 Increased shRNA abundance (Z-score > 2) GR00366-A-77 9.9 NAPSA
32 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.9 WT1

MGI Mouse Phenotypes related to Papillary Adenofibroma:

45 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.45 ARID1A ARID1B CDKN2A FANCA GATA3 GNAS
2 nervous system MP:0003631 10.35 ARID1A ARID1B CALB2 CDKN2A GATA3 GNAS
3 growth/size/body region MP:0005378 10.35 ARID1A ARID1B CDKN2A FANCA GATA3 GNAS
4 neoplasm MP:0002006 10.34 ARID1A CDKN2A FANCA GNAS MSH2 MSH6
5 endocrine/exocrine gland MP:0005379 10.34 ARID1A CDKN2A FANCA GATA3 GNAS HNF1B
6 cellular MP:0005384 10.3 ARID1A CDKN2A FANCA GATA3 GNAS HNF1B
7 immune system MP:0005387 10.28 ARID1A ARID1B CDKN2A GATA3 GNAS HNF1B
8 muscle MP:0005369 10.26 ARID1A ARID1B CDKN2A GATA3 GNAS HNF1B
9 embryo MP:0005380 10.25 ARID1A CDKN2A FANCA GATA3 GNAS HNF1B
10 normal MP:0002873 10.24 ARID1A CALB2 GATA3 GNAS PAX8 PTEN
11 renal/urinary system MP:0005367 10.22 ARID1B GATA3 GNAS HNF1B PAX8 PTEN
12 cardiovascular system MP:0005385 10.21 ARID1A ARID1B CDKN2A FANCA GATA3 GNAS
13 no phenotypic analysis MP:0003012 10.19 ARID1A CDKN2A GATA3 GNAS PAX8 SLX4
14 digestive/alimentary MP:0005381 10.15 CDKN2A GATA3 GNAS HNF1B MSH2 PTEN
15 craniofacial MP:0005382 10.08 ARID1A FANCA GATA3 GNAS PAX8 SLX4
16 reproductive system MP:0005389 10.07 ARID1A ARID1B CDKN2A FANCA GATA3 PAX8
17 skeleton MP:0005390 10.02 ARID1A CDKN2A FANCA GATA3 GNAS PAX8
18 hematopoietic system MP:0005397 10 ARID1A ARID1B CDKN2A FANCA GATA3 GNAS
19 vision/eye MP:0005391 9.96 ARID1A CDKN2A FANCA GATA3 GNAS PAX8
20 mortality/aging MP:0010768 9.86 ARID1A ARID1B CDKN2A FANCA GATA3 GNAS
21 integument MP:0010771 9.32 ARID1B CDKN2A GATA3 GNAS MSH2 MSH6

Drugs & Therapeutics for Papillary Adenofibroma

Search Clinical Trials, NIH Clinical Center for Papillary Adenofibroma

Genetic Tests for Papillary Adenofibroma

Anatomical Context for Papillary Adenofibroma

Organs/tissues related to Papillary Adenofibroma:

MalaCards : Cervix, Uterus, Ovary

Publications for Papillary Adenofibroma

Articles related to Papillary Adenofibroma:

(show all 18)
# Title Authors PMID Year
1
Pitfalls of Frozen Section in Gynecological Pathology: A Case of Ovarian Serous Surface Papillary Adenofibroma Imitating Malignancy. 62
30563377 2019
2
Serous surface papillary adenofibroma of the ovary: impersonator of ovarian malignancy. 62
24484475 2014
3
Unusual presentation of rare case of papillary adenofibroma of cervix in a young woman. 62
22606457 2012
4
Mammary-like gland adenoma of the vulva: review of 46 cases. 62
19404851 2009
5
Papillary adenofibroma of the cervix: a case report. 62
16041681 2005
6
[Endometrial adenofibroma]. 62
11462961 2001
7
Papillary adenofibroma of cervix. 62
10638132 1999
8
Papillary adenofibroma of the uterine cervix. A case report. 62
8927449 1996
9
[The malignant potential of adenofibroma and cystadenofibroma of the ovary and mesovarium. 118 cases including 13 proliferative and 5 carcinomatous]. 62
8463564 1993
10
Papillary adenofibroma of the uterus. Report of a case involved by adenocarcinoma and review of the literature. 62
1595599 1992
11
Papillary adenofibroma of the cervix. An unusual tumour of the cervix. 62
3505509 1987
12
Papillary adenofibroma of the endometrium: case report and review of the literature. 62
6489832 1984
13
Bilateral papillary adenofibroma of the fallopian tube. 62
7468528 1981
14
[Papillary adenofibroma of the uterus: fact or fancy? (author's transl)]]. 62
510899 1979
15
[Papillary polypoid adenofibroma of the uterine body (author's transl)]. 62
422027 1979
16
Adenomyomatosis of endometrium and endocervix-a hamartoma. 62
1155381 1975
17
Papillary adenofibroma of the uterus: a benign mesodermal mixed tumor of Müllerian orgin. 62
4364374 1973
18
Papillary adenofibroma of the uterine cervix. 62
5558981 1971

Variations for Papillary Adenofibroma

Expression for Papillary Adenofibroma

Search GEO for disease gene expression data for Papillary Adenofibroma.

Pathways for Papillary Adenofibroma

Pathways related to Papillary Adenofibroma according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.53 SLX4 POLE MSH6 MSH2 FANCA
2
Show member pathways
12.39 SLX4 POLE MSH6 MSH2 FANCA
3 12.19 SMARCA4 MSH6 MSH2 FANCA CDKN2A
4
Show member pathways
11.98 STK11 SMARCA4 GNAS ARID1A
5
Show member pathways
11.61 SMARCA4 GNAS ARID1B ARID1A
6 11.55 STK11 PTEN CDKN2A
7 11.53 STK11 SMARCA4 PTEN MSH6 MSH2
8
Show member pathways
11.52 SMARCA4 ARID1B ARID1A
9
Show member pathways
11.38 SMARCA4 MSH6 MSH2 FANCA
10 11.16 MSH2 MSH6 PTEN
11 11.12 ARID1A ARID1B SMARCA4
12
Show member pathways
10.46 SMARCA4 CDKN2A ARID1B ARID1A

GO Terms for Papillary Adenofibroma

Cellular components related to Papillary Adenofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 10.59 ARID1A ARID1B CDKN2A FANCA GATA3 HNF1B
2 chromatin GO:0000785 10.32 ARID1A ARID1B FANCA GATA3 HNF1B MSH6
3 SWI/SNF complex GO:0016514 9.93 SMARCA4 ARID1B ARID1A
4 nBAF complex GO:0071565 9.8 SMARCA4 ARID1B ARID1A
5 npBAF complex GO:0071564 9.73 SMARCA4 ARID1B ARID1A
6 MutSalpha complex GO:0032301 9.71 MSH6 MSH2
7 bBAF complex GO:0140092 9.63 SMARCA4 ARID1B ARID1A
8 DNA packaging complex GO:0044815 9.13 SMARCA4 ARID1B ARID1A
9 SWI/SNF superfamily-type complex GO:0070603 8.8 SMARCA4 ARID1B ARID1A

Biological processes related to Papillary Adenofibroma according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 10.19 WT1 PAX8 HNF1B GATA3
2 negative regulation of cell growth GO:0030308 10.16 WT1 STK11 SMARCA4 CDKN2A
3 positive regulation of DNA-templated transcription GO:0045893 10.13 ARID1A ARID1B CDKN2A GATA3 HNF1B PAX8
4 positive regulation of miRNA transcription GO:1902895 10.1 WT1 SMARCA4 GATA3
5 positive regulation of myoblast differentiation GO:0045663 10.08 SMARCA4 ARID1B ARID1A
6 male gonad development GO:0008584 10.08 WT1 MSH2 GATA3 FANCA
7 positive regulation of double-strand break repair GO:2000781 10.06 ARID1A ARID1B SMARCA4
8 regulation of mitotic metaphase/anaphase transition GO:0030071 10 SMARCA4 ARID1B ARID1A
9 cellular response to DNA damage stimulus GO:0006974 10 STK11 SLX4 POLE MSH6 MSH2 FANCA
10 cellular response to gonadotropin stimulus GO:0071371 9.92 WT1 PAX8
11 otic vesicle development GO:0071599 9.92 PAX8 GATA3
12 positive regulation of helicase activity GO:0051096 9.91 MSH6 MSH2
13 pronephros development GO:0048793 9.91 PAX8 HNF1B
14 metanephric S-shaped body morphogenesis GO:0072284 9.88 WT1 PAX8
15 regulation of nucleotide-excision repair GO:2000819 9.88 SMARCA4 ARID1B ARID1A
16 metanephric epithelium development GO:0072207 9.87 WT1 PAX8
17 regulation of G0 to G1 transition GO:0070316 9.85 SMARCA4 ARID1B ARID1A
18 somatic recombination of immunoglobulin gene segments GO:0016447 9.81 MSH2 MSH6
19 positive regulation of thyroid hormone generation GO:2000611 9.8 GATA3 PAX8
20 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.73 HNF1B PAX8
21 maintenance of DNA repeat elements GO:0043570 9.71 MSH6 MSH2
22 positive regulation of cell differentiation GO:0045597 9.7 SMARCA4 GATA3 ARID1B ARID1A
23 regulation of G1/S transition of mitotic cell cycle GO:2000045 9.56 SMARCA4 CDKN2A ARID1B ARID1A
24 mesonephric tubule development GO:0072164 9.55 PAX8 HNF1B
25 nephric duct formation GO:0072179 9.5 HNF1B GATA3
26 positive regulation of T cell differentiation GO:0045582 9.23 SMARCA4 GATA3 ARID1B ARID1A

Molecular functions related to Papillary Adenofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP-dependent activity, acting on DNA GO:0008094 9.73 SMARCA4 MSH6 MSH2
2 MutLalpha complex binding GO:0032405 9.71 MSH6 MSH2
3 oxidized purine DNA binding GO:0032357 9.67 MSH6 MSH2
4 guanine/thymine mispair binding GO:0032137 9.62 MSH6 MSH2
5 DNA binding GO:0003677 9.62 WT1 SMARCA4 SLX4 POLE PAX8 MSH6
6 single guanine insertion binding GO:0032142 9.46 MSH6 MSH2
7 single thymine insertion binding GO:0032143 9.26 MSH2 MSH6

Sources for Papillary Adenofibroma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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