Papillary Adenofibroma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Papillary Adenofibroma

MalaCards integrated aliases for Papillary Adenofibroma:

Name: Papillary Adenofibroma ¹² ¹⁵ ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5479

NCIt ⁴⁹ C8986

SNOMED-CT ⁶⁷ 2962009

UMLS ⁷¹ C1377850

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Summaries for Papillary Adenofibroma

Disease Ontology : ¹² An adenofibroma that is characterized by finger-like projections on histology.

MalaCards based summary : Papillary Adenofibroma is related to adenofibroma and congenital granular cell tumor. An important gene associated with Papillary Adenofibroma is PTEN (Phosphatase And Tensin Homolog), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Platelet Aggregation Inhibitor Pathway, Pharmacodynamics. Affiliated tissues include liver, heart and cervix, and related phenotypes are hematopoietic system and homeostasis/metabolism

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Related Diseases for Papillary Adenofibroma

Diseases related to Papillary Adenofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 193)

#	Related Disease	Score	Top Affiliating Genes
1	adenofibroma	10.6
2	congenital granular cell tumor	10.2	CD34 CD2AP
3	chordoid meningioma	10.2	CD34 CD2AP
4	subungual glomus tumor	10.2	CD34 CD2AP
5	acquired color blindness	10.2	F3 CD2AP
6	vulvar benign neoplasm	10.2	CD34 CD2AP
7	pediatric angiosarcoma	10.2	VWF CD34
8	clear cell meningioma	10.2	CD34 CD2AP
9	heart cancer	10.2	CD34 CD2AP
10	kaposiform hemangioendothelioma	10.1	VWF CD34
11	breast hemangioma	10.1	VWF CD34
12	lymphangiosarcoma	10.1	VWF CD34
13	capillary lymphangioma	10.1	VWF CD34
14	thyroid angiosarcoma	10.1	VWF CD34
15	respiratory system benign neoplasm	10.1	PTEN CD34
16	acquired von willebrand syndrome	10.1	VWF F3
17	grange syndrome	10.1	VWF F3
18	carotid artery thrombosis	10.1	VWF F3
19	angiodysplasia	10.1	VWF F3
20	capillary disease	10.1	VWF CD34
21	central nervous system benign neoplasm	10.1	PTEN CD34
22	capillary hemangioma	10.1	VWF CD34
23	factor xii deficiency	10.1	VWF F3
24	uterine benign neoplasm	10.1	PTEN CD34
25	drug-induced lupus erythematosus	10.1	VWF CD34
26	reproductive organ benign neoplasm	10.1	PTEN CD34
27	hemophilia a	10.1	VWF F3
28	lipomatosis, multiple	10.1	PTEN CD34
29	adenosarcoma	10.1
30	cervical adenofibroma	10.1
31	coronary thrombosis	10.1	VWF F3
32	intermediate coronary syndrome	10.1	VWF F3
33	cardiovascular cancer	10.1	VWF CD34
34	vascular cancer	10.1	VWF CD34
35	retinal vein occlusion	10.0	F3 F2
36	klippel-trenaunay-weber syndrome	10.0	F2 CD2AP
37	thrombasthenia	10.0	F3 F2
38	gastric hemangioma	10.0	F3 F2
39	fournier gangrene	10.0	F3 F2
40	synovial angioma	10.0	F3 F2
41	blue toe syndrome	10.0	F3 F2
42	emphysematous cholecystitis	10.0	F3 F2
43	dic in newborn	10.0	F3 F2
44	femoral neuropathy	10.0	F3 F2
45	lemierre's syndrome	10.0	F3 F2
46	intracranial sinus thrombosis	10.0	F3 F2
47	cerebral sinovenous thrombosis	10.0	F3 F2
48	prothrombin deficiency	10.0	F3 F2
49	hemopericardium	10.0	F3 F2
50	sagittal sinus thrombosis	10.0	F3 F2

Graphical network of the top 20 diseases related to Papillary Adenofibroma:

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Symptoms & Phenotypes for Papillary Adenofibroma

MGI Mouse Phenotypes related to Papillary Adenofibroma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.73	CD2AP CD34 F2 F3 PTEN VWF
2	homeostasis/metabolism	MP:0005376	9.7	AFP CD2AP CD34 F2 F3 PTEN
3	immune system	MP:0005387	9.43	CD2AP CD34 F2 F3 PTEN VWF
4	neoplasm	MP:0002006	8.92	AFP CD34 F3 PTEN

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Drugs & Therapeutics for Papillary Adenofibroma

Search Clinical Trials , NIH Clinical Center for Papillary Adenofibroma

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Genetic Tests for Papillary Adenofibroma

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Anatomical Context for Papillary Adenofibroma

MalaCards organs/tissues related to Papillary Adenofibroma:

⁴⁰

Liver, Heart, Cervix, Uterus, Ovary, Brain, Colon

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Publications for Papillary Adenofibroma

Articles related to Papillary Adenofibroma:

(show all 18)

#	Title	Authors	PMID	Year
1	Pitfalls of Frozen Section in Gynecological Pathology: A Case of Ovarian Serous Surface Papillary Adenofibroma Imitating Malignancy. ⁶¹	Jones AMK...Heller DS	30563377	2019
2	Serous surface papillary adenofibroma of the ovary: impersonator of ovarian malignancy. ⁶¹	Ulker V...Bakir B	24484475	2014
3	Unusual presentation of rare case of papillary adenofibroma of cervix in a young woman. ⁶¹	Navada HM...Jayaprakash CS	22606457	2012
4	Mammary-like gland adenoma of the vulva: review of 46 cases. ⁶¹	Scurry J...Szabo R	19404851	2009
5	Papillary adenofibroma of the cervix: a case report. ⁶¹	Haberal A...Cavusoglu D	16041681	2005
6	[Endometrial adenofibroma]. ⁶¹	Bellil K...Zitouna M	11462961	2001
7	Papillary adenofibroma of cervix. ⁶¹	Mohan H...Mohan P	10638132	1999
8	Papillary adenofibroma of the uterine cervix. A case report. ⁶¹	Fratini D...Cavaliere A	8927449	1996
9	[The malignant potential of adenofibroma and cystadenofibroma of the ovary and mesovarium. 118 cases including 13 proliferative and 5 carcinomatous]. ⁶¹	Randrianjafisamindrakotroka NS...Philippe E	8463564	1993
10	Papillary adenofibroma of the uterus. Report of a case involved by adenocarcinoma and review of the literature. ⁶¹	Miller KN...McClure SP	1595599	1992
11	Papillary adenofibroma of the cervix. An unusual tumour of the cervix. ⁶¹	Candes FP...Saudagar PG	3505509	1987
12	Papillary adenofibroma of the endometrium: case report and review of the literature. ⁶¹	Altaras M...Ben Aderet N	6489832	1984
13	Bilateral papillary adenofibroma of the fallopian tube. ⁶¹	Chen KT	7468528	1981
14	[Papillary adenofibroma of the uterus: fact or fancy? (author's transl)]]. ⁶¹	Cremer H...Korte W	510899	1979
15	[Papillary polypoid adenofibroma of the uterine body (author's transl)]. ⁶¹	Egger H...Paterok E	422027	1979
16	Adenomyomatosis of endometrium and endocervix-a hamartoma. ⁶¹	Silverberg SG	1155381	1975
17	Papillary adenofibroma of the uterus: a benign mesodermal mixed tumor of Müllerian orgin. ⁶¹	Vellios F...Reagen JW	4364374	1973
18	Papillary adenofibroma of the uterine cervix. ⁶¹	Abell MR	5558981	1971

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Genes for Papillary Adenofibroma

Genes related to Papillary Adenofibroma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PTEN	Phosphatase And Tensin Homolog	Protein Coding	4.65	DISEASES inferred ¹⁵
2	CD2AP	CD2 Associated Protein	Protein Coding	4.41	DISEASES inferred ¹⁵
3	VWF	Von Willebrand Factor	Protein Coding	3.81	DISEASES inferred ¹⁵
4	F3	Coagulation Factor III, Tissue Factor	Protein Coding	3.71	DISEASES inferred ¹⁵
5	F2	Coagulation Factor II, Thrombin	Protein Coding	3.56	DISEASES inferred ¹⁵
6	AFP	Alpha Fetoprotein	Protein Coding	3.46	DISEASES inferred ¹⁵
7	CD34	CD34 Molecule	Protein Coding	3.38	DISEASES inferred ¹⁵

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Variations for Papillary Adenofibroma

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Expression for Papillary Adenofibroma

Search GEO for disease gene expression data for Papillary Adenofibroma.

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Pathways for Papillary Adenofibroma

Pathways related to Papillary Adenofibroma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Formation of Fibrin Clot (Clotting Cascade) ⁶⁵ Show member pathways Blood Clotting Cascade ¹ Blood Coagulation Signaling Pathways ⁶⁴ Common Pathway of Fibrin Clot Formation ⁶⁵ Extrinsic Pathway of Fibrin Clot Formation ⁶⁵ Extrinsic Prothrombin Activation Pathway ⁶³ Intrinsic Pathway of Fibrin Clot Formation ⁶⁵	11.33	VWF F3 F2
2	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics ⁶⁰	10.96	VWF F2
3	Complement and coagulation cascades ¹ ³⁶	10.96	VWF F3 F2
4	FOXA2 and FOXA3 transcription factor networks ¹	10.8	F2 AFP

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GO Terms for Papillary Adenofibroma

Cellular components related to Papillary Adenofibroma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	collagen-containing extracellular matrix	GO:0062023	9.13	VWF F3 F2
2	extracellular region	GO:0005576	9.1	VWF PTEN F3 F2 CD34 AFP

Biological processes related to Papillary Adenofibroma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	blood coagulation	GO:0007596	9.33	VWF F3 F2
2	positive regulation of protein localization to nucleus	GO:1900182	9.26	F2 CD2AP
3	blood coagulation, intrinsic pathway	GO:0007597	8.96	VWF F2
4	hemostasis	GO:0007599	8.8	VWF F3 F2

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