MCID: PPL019
MIFTS: 32

Papillary Conjunctivitis

Categories: Neuronal diseases

Aliases & Classifications for Papillary Conjunctivitis

MalaCards integrated aliases for Papillary Conjunctivitis:

Name: Papillary Conjunctivitis 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:2458
NCIt 50 C35616
SNOMED-CT 67 416878008
UMLS 70 C0854165

Summaries for Papillary Conjunctivitis

MalaCards based summary : Papillary Conjunctivitis is related to vernal keratoconjunctivitis and giant papillary conjunctivitis. An important gene associated with Papillary Conjunctivitis is CCL11 (C-C Motif Chemokine Ligand 11), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include eye, skin and t cells, and related phenotype is immune system.

Related Diseases for Papillary Conjunctivitis

Diseases related to Papillary Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 313)
# Related Disease Score Top Affiliating Genes
1 vernal keratoconjunctivitis 30.6 IL4 CCL24 CCL11
2 giant papillary conjunctivitis 30.4 LTF IL7 IL6 IL4 IL11 CXCL9
3 allergic conjunctivitis 30.3 IL4 CXCL8 CCL11
4 blepharitis 30.0 LTF IL4 CXCL8
5 keratitis, hereditary 29.8 IL6 CXCL9 CXCL8
6 conjunctivitis 29.6 IL7 IL6 IL4 CXCL9 CXCL8 CCL24
7 keratoconjunctivitis 29.4 IL6 IL4 CXCL8 CCL24 CCL2 CCL11
8 eye disease 29.3 IL6 IL4 CXCL8 CCL2 CCL11
9 proteasome-associated autoinflammatory syndrome 1 29.1 IL6 IL4 CXCL8 CCL2 CCL11
10 allergic disease 29.0 PRG2 IL6 IL4 CXCL8 CCL24 CCL11
11 vernal conjunctivitis 10.3
12 pemphigoid 10.3 IL4 CCL11
13 chronic asthma 10.3 IL4 CCL11
14 loiasis 10.3 IL4 CCL11
15 trichinosis 10.3 IL4 CCL11
16 eosinophilic gastritis 10.3 CCL24 CCL11
17 sodoku disease 10.3 IL11 CCL11
18 cervicitis 10.3 IL6 CXCL8
19 intrinsic asthma 10.3 IL4 CCL24
20 strongyloidiasis 10.3 IL4 CCL11
21 enterocolitis 10.2 IL6 CXCL8
22 tungiasis 10.2 IL4 CXCL8
23 vulvovaginitis 10.2 CXCL8 CCL11
24 eales disease 10.2 IL6 IL4
25 scabies 10.2 CXCL8 CCL11
26 idiopathic anterior uveitis 10.2 IL6 CXCL8
27 ptosis 10.2
28 streptococcal toxic-shock syndrome 10.2 IL6 CXCL8
29 acute transverse myelitis 10.2 IL6 CXCL8
30 idiopathic nephrotic syndrome 10.2 IL6 IL4
31 osteitis fibrosa 10.2 IL6 IL11
32 epilepsy, familial temporal lobe, 2 10.2 IL6 IL11
33 suppurative periapical periodontitis 10.2 IL6 CXCL8
34 periapical periodontitis 10.2 IL6 CXCL8
35 bacterial conjunctivitis 10.2 IL6 CXCL8
36 tracheitis 10.2 IL6 CXCL8
37 taeniasis 10.2 IL6 IL4
38 autoimmune vasculitis 10.2 IL6 IL4
39 progressive myoclonus epilepsy 8 10.2 IL6 CXCL8
40 atopic keratoconjunctivitis 10.2 PRG2 IL4
41 pyuria 10.2 IL6 CXCL8
42 peptic esophagitis 10.2 IL6 CXCL8
43 recurrent corneal erosion 10.2 IL6 CXCL8
44 opisthorchiasis 10.2 IL4 CXCL8
45 angiostrongyliasis 10.2 IL4 CCL24 CCL11
46 vaginal discharge 10.2 IL6 CXCL8
47 eosinophilic meningitis 10.2 IL4 CCL24 CCL11
48 eosinophilic pneumonia 10.2 IL4 CXCL8 CCL11
49 vaginitis 10.2 IL6 CXCL8
50 esophagitis, eosinophilic, 1 10.2 IL4 CCL24 CCL11

Graphical network of the top 20 diseases related to Papillary Conjunctivitis:



Diseases related to Papillary Conjunctivitis

Symptoms & Phenotypes for Papillary Conjunctivitis

MGI Mouse Phenotypes related to Papillary Conjunctivitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.23 CCL11 CCL2 CCL24 IL4 IL6 IL7

Drugs & Therapeutics for Papillary Conjunctivitis

Search Clinical Trials , NIH Clinical Center for Papillary Conjunctivitis

Genetic Tests for Papillary Conjunctivitis

Anatomical Context for Papillary Conjunctivitis

MalaCards organs/tissues related to Papillary Conjunctivitis:

40
Eye, Skin, T Cells, Neutrophil

Publications for Papillary Conjunctivitis

Articles related to Papillary Conjunctivitis:

(show top 50) (show all 362)
# Title Authors PMID Year
1
CLEAR - Contact lens complications. 61
33775382 2021
2
CLEAR - Effect of contact lens materials and designs on the anatomy and physiology of the eye. 61
33775377 2021
3
Current Knowledge in Allergic Conjunctivitis. 61
33631915 2021
4
Contact lens complications among wearers in Ghana. 61
31784334 2021
5
Adverse event rates in the retrospective cohort study of safety of paediatric soft contact lens wear: the ReCSS study. 61
33179359 2021
6
Ocular allergy test and biomarkers on the ocular surface: Clinical test for evaluating the ocular surface condition in allergic conjunctival diseases. 61
32563624 2020
7
The Presentation and Surgical Treatment of Peribulbar Dermolipomas. 61
33079762 2020
8
The treatment of recurrent conjunctival and corneal intraepithelial neoplasia with interferon alfa-2b and retinoic acid: ~9 years' follow-up on tumor control. 61
32311432 2020
9
Japanese guidelines for allergic conjunctival diseases 2020. 61
33211650 2020
10
Giant papillary conjunctivitis: A review. 61
32339665 2020
11
Thelaziasis as an uncommon cause of giant papillary conjunctivitis. 61
32586115 2020
12
Potential Biomarkers for Allergic Conjunctival Diseases. 61
32097185 2020
13
Chronic Conjunctivitis From a Retained Contact Lens. 61
30724838 2020
14
Floppy eyelid syndrome: A comprehensive review. 61
31593763 2020
15
Tear Inflammatory Molecules in Contact Lens Wearers: A Literature Review. 61
30963963 2020
16
Dupilumab-associated blepharoconjunctivitis. 61
31535057 2019
17
[Floppy eyelid syndrome : A frequently underdiagnosed entity of interdisciplinary importance]. 61
31641846 2019
18
[Application of corticosteroid eye drops for allergic eye diseases in children]. 61
30798620 2019
19
Resolution of recalcitrant chronic papillary conjunctivitis associated with epiphora following punctoplasty and lacrimal stenting. 61
30119793 2018
20
Lax eyelid syndrome (LES), obstructive sleep apnea (OSA), and ocular surface inflammation. 61
29729418 2018
21
Floppy Eyelid Syndrome: An Unfamiliar Entity for Plastic Surgeons. 61
29369905 2018
22
Surgical treatment outcome of medically refractory huge giant papillary conjunctivitis. 61
29260110 2017
23
In vivo confocal microscopic characteristics of microsporidial keratoconjunctivitis in immunocompetent adults. 61
28130350 2017
24
[Characteristics of allergic conjunctivitis with positive skin prick test]. 61
28926887 2017
25
Japanese guidelines for allergic conjunctival diseases 2017. 61
28209324 2017
26
Contact Lenses for Keratoconus- Current Practice. 61
28932340 2017
27
A retrospective analysis of vision correction and safety in keratoconus patients wearing Toris K soft contact lenses. 61
26895272 2016
28
An update on ocular allergy. 61
27490123 2016
29
Allergic manifestations of contact lens wearing. 61
27518840 2016
30
Combined medial canthopexy and lateral tarsal strip for floppy eyelid syndrome. 61
27178516 2016
31
Changes in the Eye Microbiota Associated with Contact Lens Wearing. 61
27006462 2016
32
[Ocular prosthetics. Fitting, daily use and complications]. 61
26160105 2016
33
[. Oсumethyl in the treatment of allergic diseases of eyelids and conjunctiva]. 61
27911431 2016
34
Botulinum toxin injection into the lacrimal gland for treatment of proximal nasolacrimal duct obstructions in children. 61
25427340 2014
35
Treatment of asymmetrical vernal keratoconjunctivitis with supratarsal corticosteroid injection. 61
25410033 2014
36
Compliance study of contact lens wearers in Japan--part 2: evaluation of a subscribed membership system. 61
25162289 2014
37
Risk factors for contact lens-induced papillary conjunctivitis associated with silicone hydrogel contact lens wear. 61
24681609 2014
38
[Giant papillary conjunctivitis]. 61
24799171 2014
39
Pharmacokinetic evaluation of topical calcineurin inhibitors for treatment of allergic conjunctivitis. 61
24490943 2014
40
Floppy eyelid syndrome as an indicator of the presence of glaucoma in patients with obstructive sleep apnea. 61
23807350 2014
41
A case of recalcitrant bacterial conjunctivitis. 61
24555257 2013
42
Allergic conjunctivitis: an update on diagnosis and management. 61
23974684 2013
43
Adverse events during 2 years of daily wear of silicone hydrogels in children. 61
23939292 2013
44
Ocular complications of soft contact lens wearers in a tertiary eye care centre of Nepal. 61
23238170 2013
45
Ocular physiology and comfort in neophyte subjects fitted with daily disposable silicone hydrogel contact lenses. 61
23279732 2013
46
Allergic conjunctivitis: a comprehensive review of the literature. 61
23497516 2013
47
Mechanical complications induced by silicone hydrogel contact lenses. 61
23271473 2013
48
Treatment of conjunctival and corneal epithelial neoplasia with retinoic acid and topical interferon alfa-2b: long-term follow-up. 61
22704834 2012
49
The clinical performance of lenses disposed of daily can vary considerably. 61
22890226 2012
50
Comparison of tacrolimus, fluorometholone, and saline in mild-to-moderate contact lens-induced papillary conjunctivitis. 61
22821643 2012

Variations for Papillary Conjunctivitis

Expression for Papillary Conjunctivitis

Search GEO for disease gene expression data for Papillary Conjunctivitis.

Pathways for Papillary Conjunctivitis

Pathways related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.86 PRG2 LTF IL7 IL6 IL4 IL11
2
Show member pathways
13.54 PRG2 IL7 IL6 IL4 IL11 CXCL9
3
Show member pathways
13.49 IL7 IL6 IL4 IL11 CXCL9 CXCL8
4
Show member pathways
13.39 IL7 IL6 IL4 IL11 CXCL8 CCL24
5
Show member pathways
13.26 PRG2 CXCL9 CXCL8 CCL24 CCL2 CCL11
6
Show member pathways
13.24 IL7 IL6 IL4 IL11 CXCL8 CCL2
7
Show member pathways
13.12 IL7 IL6 IL4 IL11 CXCL9 CXCL8
8
Show member pathways
12.78 CXCL9 CXCL8 CCL24 CCL2 CCL11
9
Show member pathways
12.74 PRG2 IL6 IL4 CXCL9 CXCL8 CCL11
10 12.69 IL7 IL6 IL4 CXCL8
11
Show member pathways
12.68 IL7 IL6 IL4 IL11 CXCL9 CXCL8
12
Show member pathways
12.33 IL7 IL6 IL4 IL11
13
Show member pathways
12.24 IL6 IL4 CXCL8 CCL2 CCL11
14 12.1 IL6 CXCL8 CCL2
15
Show member pathways
12.09 IL6 IL4 IL11 CXCL8 CCL11
16
Show member pathways
12.07 IL6 CXCL9 CXCL8 CCL24 CCL2 CCL11
17 11.96 IL6 CXCL8 CCL2
18 11.96 IL6 IL4 CXCL8 CCL2
19 11.93 IL7 IL6 IL4 IL11
20 11.89 IL6 IL4 CXCL8 CCL2 CCL11
21 11.85 IL7 IL6 IL4 IL11
22 11.81 IL6 CXCL8 CCL2
23 11.81 IL6 IL11 CXCL8 CCL2
24 11.72 IL6 IL4 CXCL8
25 11.49 IL6 CXCL8 CCL2
26 11.45 IL6 CXCL8 CCL11
27 11.45 IL6 IL4 CXCL8 CCL2
28 11.35 IL6 IL4 CXCL8 CCL2 CCL11
29 11.31 IL6 CXCL8 CCL2
30 11.27 IL7 IL6 IL4
31 11.17 IL7 IL6 IL4 IL11
32 10.94 IL6 CXCL8
33 10.93 CCL2 CCL11
34 10.73 IL6 IL4
35 10.23 PRG2 IL7 IL6 IL4 IL11 CXCL9

GO Terms for Papillary Conjunctivitis

Cellular components related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 LTF IL7 IL6 IL4 IL11 CXCL9
2 extracellular region GO:0005576 9.36 PRG2 LTF IL7 IL6 IL4 IL11

Biological processes related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.09 IL7 IL6 IL4 IL11 CXCL9 CXCL8
2 positive regulation of cell proliferation GO:0008284 9.93 IL7 IL6 IL4 IL11
3 negative regulation of apoptotic process GO:0043066 9.92 LTF IL7 IL6 IL4
4 positive regulation of gene expression GO:0010628 9.91 IL7 IL6 IL4 CXCL8
5 inflammatory response GO:0006954 9.88 IL6 CXCL9 CXCL8 CCL24 CCL2 CCL11
6 cellular response to lipopolysaccharide GO:0071222 9.84 IL6 CXCL9 CXCL8 CCL2
7 cellular response to tumor necrosis factor GO:0071356 9.81 CXCL8 CCL24 CCL2 CCL11
8 cytoskeleton organization GO:0007010 9.79 CCL24 CCL2 CCL11
9 cellular response to interleukin-1 GO:0071347 9.78 CXCL8 CCL24 CCL2 CCL11
10 positive regulation of angiogenesis GO:0045766 9.77 CXCL8 CCL24 CCL11
11 chemotaxis GO:0006935 9.77 CXCL9 CXCL8 CCL24 CCL2 CCL11
12 regulation of cell shape GO:0008360 9.76 CCL24 CCL2 CCL11
13 humoral immune response GO:0006959 9.76 LTF IL7 IL6 CCL2
14 cellular response to interferon-gamma GO:0071346 9.73 CCL24 CCL2 CCL11
15 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.72 LTF CXCL9 CXCL8
16 lymphocyte chemotaxis GO:0048247 9.7 CCL24 CCL2 CCL11
17 eosinophil chemotaxis GO:0048245 9.67 CCL24 CCL2 CCL11
18 neutrophil chemotaxis GO:0030593 9.65 CXCL9 CXCL8 CCL24 CCL2 CCL11
19 innate immune response in mucosa GO:0002227 9.63 LTF IL4
20 negative regulation of neurogenesis GO:0050768 9.62 IL6 CCL11
21 monocyte chemotaxis GO:0002548 9.62 IL6 CCL24 CCL2 CCL11
22 positive regulation of T cell differentiation GO:0045582 9.59 IL7 IL4
23 positive regulation of myoblast fusion GO:1901741 9.58 IL4 CXCL9
24 PERK-mediated unfolded protein response GO:0036499 9.57 CXCL8 CCL2
25 chemokine-mediated signaling pathway GO:0070098 9.55 CXCL9 CXCL8 CCL24 CCL2 CCL11
26 cytokine-mediated signaling pathway GO:0019221 9.5 IL7 IL6 IL4 IL11 CXCL8 CCL2
27 immune response GO:0006955 9.28 PRG2 IL7 IL6 IL4 CXCL9 CXCL8

Molecular functions related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.56 IL7 IL6 IL4 IL11
2 cytokine receptor binding GO:0005126 9.4 IL7 IL4
3 CXCR chemokine receptor binding GO:0045236 9.37 CXCL9 CXCL8
4 chemokine activity GO:0008009 9.35 CXCL9 CXCL8 CCL24 CCL2 CCL11
5 CCR chemokine receptor binding GO:0048020 9.33 CCL24 CCL2 CCL11
6 CCR3 chemokine receptor binding GO:0031728 9.32 CCL24 CCL11
7 cytokine activity GO:0005125 9.28 IL7 IL6 IL4 IL11 CXCL9 CXCL8

Sources for Papillary Conjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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