MCID: PPL019
MIFTS: 37

Papillary Conjunctivitis

Categories: Eye diseases

Aliases & Classifications for Papillary Conjunctivitis

MalaCards integrated aliases for Papillary Conjunctivitis:

Name: Papillary Conjunctivitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2458
NCIt 50 C35616
SNOMED-CT 68 416878008
UMLS 73 C0854165

Summaries for Papillary Conjunctivitis

MalaCards based summary : Papillary Conjunctivitis is related to giant papillary conjunctivitis and vernal keratoconjunctivitis. An important gene associated with Papillary Conjunctivitis is CCL11 (C-C Motif Chemokine Ligand 11), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Loteprednol and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye and neutrophil.

Related Diseases for Papillary Conjunctivitis

Diseases related to Papillary Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 giant papillary conjunctivitis 32.3 CCL11 CXCL8 IL11 IL4
2 vernal keratoconjunctivitis 30.5 CCL11 IL4
3 blepharitis 30.3 CCL11 IL4
4 conjunctivitis 29.9 CCL11 CXCL8 IL4 IL6
5 keratoconjunctivitis 29.7 CCL11 CXCL8 IL4
6 blepharoconjunctivitis 10.5 CCL11 IL4
7 angiostrongyliasis 10.5 CCL11 IL4
8 eosinophilic meningitis 10.5 CCL11 IL4
9 gastrointestinal allergy 10.5 CCL11 IL4
10 chronic conjunctivitis 10.5 CCL11 IL4
11 eosinophilic gastritis 10.5 CCL11 IL4
12 kimura disease 10.5 CCL11 IL4
13 folliculitis 10.5 CCL11 IL4
14 conjunctival disease 10.5 CCL11 IL4
15 pulmonary eosinophilia 10.5 CCL11 IL4
16 onchocerciasis 10.5 CCL11 IL4
17 dermatitis herpetiformis 10.5 CCL11 IL4
18 chronic eosinophilic pneumonia 10.5 CCL11 IL6
19 leukocyte disease 10.4 CCL11 IL4
20 myelitis 10.4 CCL11 IL6
21 microscopic colitis 10.4 IL4 IL6
22 primary amebic meningoencephalitis 10.4 IL4 IL6
23 alexithymia 10.4 IL4 IL6
24 eales disease 10.4 IL4 IL6
25 proliferative glomerulonephritis 10.4 IL4 IL6
26 aphthous stomatitis 10.4 IL4 IL6
27 scabies 10.3 CCL11 CXCL8
28 rasmussen encephalitis 10.3 IL4 IL6
29 vulvovaginitis 10.3 CCL11 CXCL8
30 extrinsic cardiomyopathy 10.3 IL4 IL6
31 rheumatic heart disease 10.3 IL4 IL6
32 keratoconjunctivitis sicca 10.3 IL4 IL6
33 paracoccidioidomycosis 10.3 IL4 IL6
34 tungiasis 10.3 CXCL8 IL4
35 spondyloarthropathy 10.3 IL4 IL6
36 joint disorders 10.3 IL11 IL6
37 opisthorchiasis 10.3 CXCL8 IL4
38 parasitic protozoa infectious disease 10.3 IL4 IL6
39 common cold 10.3 CCL11 CXCL8
40 primary bacterial infectious disease 10.2 IL4 IL6
41 recurrent corneal erosion 10.2 CXCL8 IL6
42 bagassosis 10.2 CXCL8 IL6
43 acute transverse myelitis 10.2 CXCL8 IL6
44 streptococcal toxic-shock syndrome 10.2 CXCL8 IL6
45 denture stomatitis 10.2 CXCL8 IL6
46 funisitis 10.2 CXCL8 IL6
47 capillary leak syndrome 10.2 CXCL8 IL6
48 meconium aspiration syndrome 10.2 CXCL8 IL6
49 vaginal disease 10.2 CXCL8 IL6
50 toxoplasmosis 10.2 IL4 IL6

Graphical network of the top 20 diseases related to Papillary Conjunctivitis:



Diseases related to Papillary Conjunctivitis

Symptoms & Phenotypes for Papillary Conjunctivitis

Drugs & Therapeutics for Papillary Conjunctivitis

Drugs for Papillary Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Loteprednol Approved Phase 4 82034-46-6, 129260-79-3 444025 9865442
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4 Anti-Allergic Agents Phase 4
5 Antiemetics Phase 4
6 Anti-Inflammatory Agents Phase 4
7 Antineoplastic Agents, Hormonal Phase 4
8 Autonomic Agents Phase 4
9 Gastrointestinal Agents Phase 4
10 glucocorticoids Phase 4
11 Hormone Antagonists Phase 4
12 Hormones Phase 4
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
14 Methylprednisolone acetate Phase 4
15 Methylprednisolone Hemisuccinate Phase 4
16 Neuroprotective Agents Phase 4
17 Peripheral Nervous System Agents Phase 4
18 Prednisolone acetate Phase 4
19 Prednisolone hemisuccinate Phase 4
20 Prednisolone phosphate Phase 4
21 Protective Agents Phase 4
22 Pharmaceutical Solutions Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study to Evaluate the Safety and Efficacy of Lotemax Ophthalmic Suspension 0.5% Active, not recruiting NCT01437982 Phase 4 Loteprednol Etabonate;Prednisolone Acetate 1% Oph Susp
2 Clinical Performance of a New Daily Disposable Contact Lens Worn in a Neophyte Population. Completed NCT00708032 Not Applicable
3 Perforated Punctal Plugs for Treatment of Papillary Conjunctivitis in Otherwise Healthy Patients Completed NCT02503956 Not Applicable
4 BIOCLEAN FIRST CARE EX in Combination With Biofinity Lens Completed NCT02196766 Not Applicable
5 Clinical Performance of Atypical Contact Lens Powers on Subjects With Astigmatism Completed NCT00697190 Not Applicable
6 The Clinical Performance of the Biofinity Contact Lens (Comfilcon A) With Two Lens Care Systems Completed NCT02510820 Not Applicable
7 Assessment of Daily Disposable Silicone Hydrogel Lens Wear Completed NCT01093625 Not Applicable
8 Daily Disposable Silicone Hydrogel Contact Lens, Stenfilcon A, Clinical Study Completed NCT02637804 Not Applicable
9 Tangible Hydra-PEG: A Promising Solution for Scleral Lens Wearers With Dry Eye Not yet recruiting NCT03417505 Not Applicable

Search NIH Clinical Center for Papillary Conjunctivitis

Genetic Tests for Papillary Conjunctivitis

Anatomical Context for Papillary Conjunctivitis

MalaCards organs/tissues related to Papillary Conjunctivitis:

41
Eye, Neutrophil

Publications for Papillary Conjunctivitis

Articles related to Papillary Conjunctivitis:

(show top 50) (show all 118)
# Title Authors Year
1
Surgical treatment outcome of medically refractory huge giant papillary conjunctivitis. ( 29260110 )
2017
2
Risk factors for contact lens-induced papillary conjunctivitis associated with silicone hydrogel contact lens wear. ( 24681609 )
2014
3
Comparison of tacrolimus, fluorometholone, and saline in mild-to-moderate contact lens-induced papillary conjunctivitis. ( 22821643 )
2012
4
Comparison of olopatadine and fluorometholone in contact lens-induced papillary conjunctivitis. ( 20531202 )
2010
5
Contact lens induced papillary conjunctivitis with silicone hydrogel lenses. ( 19181562 )
2009
6
Tacrolimus ointment 0.03% in the eye for treatment of giant papillary conjunctivitis. ( 18216583 )
2008
7
IgE antibody on worn highly oxygen-permeable silicone hydrogel contact lenses from patients with contact lens-induced papillary conjunctivitis (CLPC). ( 18327049 )
2008
8
Papillary conjunctivitis associated with Kikuchi disease. ( 18724159 )
2008
9
Filtering bleb-induced giant papillary conjunctivitis. ( 17826299 )
2008
10
Giant papillary conjunctivitis. ( 18769199 )
2008
11
Giant papillary conjunctivitis. ( 18282547 )
2008
12
Immunohistochemical findings in prosthesis-associated giant papillary conjunctivitis. ( 17760635 )
2007
13
M cells are involved in pathogenesis of human contact lens-associated giant papillary conjunctivitis. ( 17557145 )
2007
14
Two presentations of contact lens-induced papillary conjunctivitis (CLPC) in hydrogel lens wear: local and general. ( 16432470 )
2006
15
Antibody array-generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis. ( 16767372 )
2006
16
Conjunctival cytology features of giant papillary conjunctivitis associated with ocular prostheses. ( 15677951 )
2005
17
Tear eotaxin levels in giant papillary conjunctivitis associated with ocular prosthesis. ( 14566648 )
2003
18
Contact lens chemistry and giant papillary conjunctivitis. ( 12772728 )
2003
19
Nitric oxide levels in tears of patients with mild forms of papillary conjunctivitis induced by rigid gas-permeable contact lenses. ( 11838991 )
2002
20
General and local contact lens induced papillary conjunctivitis (CLPC). ( 12033982 )
2002
21
Contact lens-induced papillary conjunctivitis is associated with increased albumin deposits on extended wear hydrogel lenses. ( 12614016 )
2002
22
Giant papillary conjunctivitis associated with an ocular prosthesis. ( 12366372 )
2001
23
Delayed tear clearance in contact lens associated papillary conjunctivitis. ( 11462163 )
2001
24
Meibomian gland status and prevalence of giant papillary conjunctivitis in contact lens wearers. ( 15326900 )
2000
25
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study ( 10844086 )
2000
26
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study. ( 10703125 )
1999
27
Role of tear inflammatory mediators in contact lens-associated giant papillary conjunctivitis in soft contact lens wearers. ( 10410873 )
1999
28
Sebaceous carcinoma presenting as a unilateral papillary conjunctivitis. ( 10218701 )
1999
29
Giant papillary conjunctivitis in frequent replacement contact lens wearers: a retrospective study. ( 10444049 )
1999
30
Giant papillary conjunctivitis--a review. ( 10337425 )
1999
31
Effect of lodoxamide on tear leukotriene levels in giant papillary conjunctivitis associated with ocular prosthesis. ( 9785608 )
1998
32
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. ( 9001768 )
1997
33
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. The Loteprednol Etabonate Giant Papillary Conjunctivitis Study Group I. ( 9124242 )
1997
34
Increased numbers of Langerhans cell and expression of HLA-Dr antigen in the giant papilla of patients with giant papillary conjunctivitis. ( 8755197 )
1996
35
Contact lens type, material, and deposits and giant papillary conjunctivitis. ( 7712614 )
1995
36
Effect of extended wear disposable contact lenses on tear LTC4 in giant papillary conjunctivitis. ( 22827277 )
1995
37
Localised giant papillary conjunctivitis secondary to a dermolipoma. ( 7556754 )
1995
38
Tear LTC4 levels in patients with subclinical contact lens related giant papillary conjunctivitis. ( 7586473 )
1995
39
Bilateral giant papillary conjunctivitis related to glaucoma drainage surgery blebs. ( 7995075 )
1994
40
Giant papillary conjunctivitis. ( 7886881 )
1994
41
A rare case of chronic papillary conjunctivitis diagnosed after several years of evolution. Clinical and pathological findings. ( 8044334 )
1993
42
Safety and efficacy of loteprednol etabonate for treatment of papillae in contact lens-associated giant papillary conjunctivitis. ( 8319490 )
1993
43
Causative factors in unilateral giant papillary conjunctivitis. ( 8495560 )
1993
44
Meibomian gland function and giant papillary conjunctivitis. ( 8420369 )
1993
45
Unusual causes of giant papillary conjunctivitis. ( 8458237 )
1993
46
N-acetyl-aspartyl glutamic acid (NAAGA) topical eyedrops in the treatment of giant papillary conjunctivitis (GPC). ( 7910133 )
1993
47
Comparison of the clinical performance of the Acuvue disposable contact lens and CSI lens in patients with giant papillary conjunctivitis. ( 8470716 )
1993
48
Nedocromil sodium in contact-lens-associated papillary conjunctivitis. ( 8253222 )
1993
49
Meibomian gland function and giant papillary conjunctivitis. ( 8420368 )
1993
50
Daily enzyme cleaning for giant papillary conjunctivitis. ( 1498575 )
1992

Variations for Papillary Conjunctivitis

Expression for Papillary Conjunctivitis

Search GEO for disease gene expression data for Papillary Conjunctivitis.

Pathways for Papillary Conjunctivitis

Pathways related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.7 CCL11 CXCL8 IL11 IL4 IL6 IL7
2
Show member pathways
13.54 CCL11 CXCL8 IL11 IL4 IL6 IL7
3
Show member pathways
13.38 CCL11 CXCL8 IL11 IL4 IL6 IL7
4
Show member pathways
13.22 CCL11 CXCL8 IL11 IL4 IL6 IL7
5
Show member pathways
13.12 CCL11 CXCL8 IL11 IL4 IL6 IL7
6
Show member pathways
13.06 CCL11 CXCL8 IL11 IL4 IL6 IL7
7
Show member pathways
13 CCL11 CXCL8 IL11 IL4 IL6 IL7
8
Show member pathways
12.68 CCL11 IL4 IL6 IL7
9
Show member pathways
12.66 CCL11 CXCL8 IL4 IL6
10 12.63 CXCL8 IL4 IL6 IL7
11
Show member pathways
12.54 CXCL8 IL4 IL6
12
Show member pathways
12.32 CXCL8 IL11 IL4 IL6 IL7
13
Show member pathways
12.17 CCL11 CXCL8 IL4 IL6
14 11.85 CXCL8 IL4 IL6
15 11.8 IL11 IL4 IL6 IL7
16
Show member pathways
11.77 CCL11 CXCL8 IL11 IL4 IL6
17 11.76 CCL11 CXCL8 IL4 IL6
18 11.71 CXCL8 IL11 IL6
19 11.67 CXCL8 IL4 IL6
20 11.66 IL11 IL4 IL6 IL7
21 11.58 IL4 IL7
22
Show member pathways
11.56 CXCL8 IL4
23 11.55 CXCL8 IL6
24 11.48 CXCL8 IL6
25 11.47 CCL11 IL4
26
Show member pathways
11.46 CXCL8 IL6
27 11.42 CXCL8 IL4 IL6
28 11.4 CXCL8 IL6
29 11.4 CXCL8 IL6
30 11.4 CCL11 CXCL8 IL6
31 11.36 CXCL8 IL6
32 11.36 CCL11 CXCL8 IL4 IL6
33 11.34 CXCL8 IL6
34 11.32 IL11 IL6
35 11.3 CCL11 IL4
36 11.21 IL4 IL6 IL7
37 11.16 CXCL8 IL6
38
Show member pathways
11.11 CCL11 CXCL8 IL11 IL4 IL6 IL7
39 10.9 CXCL8 IL6
40 10.73 IL11 IL4 IL6 IL7

GO Terms for Papillary Conjunctivitis

Cellular components related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CCL11 CXCL8 IL11 IL4 IL6 IL7
2 extracellular space GO:0005615 9.1 CCL11 CXCL8 IL11 IL4 IL6 IL7

Biological processes related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.67 CCL11 CXCL8 IL6
2 cellular response to interleukin-1 GO:0071347 9.56 CCL11 CXCL8
3 chemokine-mediated signaling pathway GO:0070098 9.55 CCL11 CXCL8
4 immune response GO:0006955 9.55 CCL11 CXCL8 IL4 IL6 IL7
5 B cell differentiation GO:0030183 9.54 IL11 IL4
6 neutrophil chemotaxis GO:0030593 9.52 CCL11 CXCL8
7 positive regulation of T cell proliferation GO:0042102 9.51 IL4 IL6
8 humoral immune response GO:0006959 9.48 IL6 IL7
9 monocyte chemotaxis GO:0002548 9.46 CCL11 IL6
10 positive regulation of B cell proliferation GO:0030890 9.43 IL4 IL7
11 regulation of signaling receptor activity GO:0010469 9.43 CCL11 CXCL8 IL11 IL4 IL6 IL7
12 negative regulation of endothelial cell apoptotic process GO:2000352 9.4 IL11 IL4
13 positive regulation of leukocyte chemotaxis GO:0002690 9.37 CXCL8 IL6
14 positive regulation of chemokine production GO:0032722 9.32 IL6 IL7
15 positive regulation of T cell differentiation GO:0045582 9.26 IL4 IL7
16 cytokine-mediated signaling pathway GO:0019221 9.1 CCL11 CXCL8 IL11 IL4 IL6 IL7

Molecular functions related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.26 CCL11 CXCL8
2 growth factor activity GO:0008083 9.26 IL11 IL4 IL6 IL7
3 cytokine receptor binding GO:0005126 9.16 IL4 IL7
4 cytokine activity GO:0005125 9.1 CCL11 CXCL8 IL11 IL4 IL6 IL7

Sources for Papillary Conjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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