MCID: PPL019
MIFTS: 37

Papillary Conjunctivitis

Categories: Neuronal diseases

Aliases & Classifications for Papillary Conjunctivitis

MalaCards integrated aliases for Papillary Conjunctivitis:

Name: Papillary Conjunctivitis 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:2458
NCIt 49 C35616
SNOMED-CT 67 416878008
UMLS 71 C0854165

Summaries for Papillary Conjunctivitis

MalaCards based summary : Papillary Conjunctivitis is related to giant papillary conjunctivitis and vernal keratoconjunctivitis. An important gene associated with Papillary Conjunctivitis is CCL11 (C-C Motif Chemokine Ligand 11), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Prednisolone phosphate and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and t cells, and related phenotypes are hematopoietic system and immune system

Related Diseases for Papillary Conjunctivitis

Diseases related to Papillary Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 261)
# Related Disease Score Top Affiliating Genes
1 giant papillary conjunctivitis 30.7 PRG2 LTF IL7 IL6 IL4 IL11
2 vernal keratoconjunctivitis 30.6 IL4 CCL24 CCL11
3 allergic conjunctivitis 30.0 IL4 CXCL8 CCL11
4 blepharitis 30.0 LTF IL6 IL4
5 allergic hypersensitivity disease 29.7 IL4 CXCL8 CCL24 CCL11
6 conjunctivitis 29.2 IL7 IL6 IL4 CXCL9 CXCL8 CCL24
7 eye disease 29.1 IL6 IL4 CXCL8 CCL2 CCL11
8 proteasome-associated autoinflammatory syndrome 1 29.0 IL6 IL4 CXCL8 CCL2 CCL11
9 keratoconjunctivitis 28.8 IL6 IL4 CXCL9 CXCL8 CCL24 CCL2
10 eosinophilic gastritis 10.4 CCL24 CCL11
11 sodoku disease 10.3 IL11 CCL11
12 intrinsic asthma 10.3 IL4 CCL24
13 idiopathic anterior uveitis 10.3 IL6 CXCL8
14 streptococcal toxic-shock syndrome 10.3 IL6 CXCL8
15 acute transverse myelitis 10.3 IL6 CXCL8
16 transverse myelitis 10.3 IL6 CXCL8
17 eales disease 10.3 IL6 IL4
18 fuchs' heterochromic uveitis 10.3 IL6 CXCL8
19 vernal conjunctivitis 10.3
20 recurrent corneal erosion 10.3 IL6 CXCL8
21 vulvovaginitis 10.3 CXCL8 CCL11
22 angiostrongyliasis 10.2 IL4 CCL24 CCL11
23 eosinophilic meningitis 10.2 IL4 CCL24 CCL11
24 osteitis fibrosa 10.2 IL6 IL11
25 pyuria 10.2 IL6 CXCL8
26 progressive myoclonus epilepsy 8 10.2 IL6 CXCL8
27 esophagitis, eosinophilic, 1 10.2 IL4 CCL24 CCL11
28 juvenile arthritis 10.2 IL6 CXCL8
29 peptic esophagitis 10.2 IL6 CXCL8
30 dermatitis herpetiformis 10.2 IL4 CXCL8 CCL11
31 periapical periodontitis 10.2 IL6 CXCL8
32 pouchitis 10.2 LTF CXCL8
33 orchitis 10.2 IL6 IL4
34 haemophilus influenzae 10.2 LTF CXCL8
35 dental pulp disease 10.2 IL6 CXCL8
36 scabies 10.2 CXCL8 CCL11
37 parasitic helminthiasis infectious disease 10.2 IL6 IL4 CCL11
38 ptosis 10.2
39 fungal meningitis 10.2 IL6 IL4
40 kimura disease 10.2 IL4 CCL11
41 cardiomyopathy, familial hypertrophic, 20 10.2 IL6 CXCL8
42 myelitis 10.2 IL6 CXCL8 CCL11
43 bullous pemphigoid 10.2 IL4 CXCL8 CCL11
44 vaginal discharge 10.2 IL6 CXCL8
45 cellular leiomyoma 10.1 CCL2 CCL11
46 stomatitis 10.1 IL6 IL4 CXCL8
47 irritant dermatitis 10.1 IL6 IL4 CXCL8
48 lichen disease 10.1 IL6 IL4 CXCL8
49 trichomoniasis 10.1 IL6 CXCL8
50 erythema multiforme 10.1 IL6 IL4 CXCL8

Graphical network of the top 20 diseases related to Papillary Conjunctivitis:



Diseases related to Papillary Conjunctivitis

Symptoms & Phenotypes for Papillary Conjunctivitis

MGI Mouse Phenotypes related to Papillary Conjunctivitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.56 CCL11 CCL24 IL4 IL6 IL7 LAX1
2 immune system MP:0005387 9.28 CCL11 CCL2 CCL24 IL4 IL6 IL7

Drugs & Therapeutics for Papillary Conjunctivitis

Drugs for Papillary Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
4
Loteprednol Approved, Experimental Phase 4 129260-79-3, 82034-46-6 9865442 444025
5
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
6 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
7
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
8 Gastrointestinal Agents Phase 4
9 Hormones Phase 4
10 Methylprednisolone Acetate Phase 4
11 Hormone Antagonists Phase 4
12 Anti-Allergic Agents Phase 4
13 glucocorticoids Phase 4
14 Antineoplastic Agents, Hormonal Phase 4
15 Neuroprotective Agents Phase 4
16 Antiemetics Phase 4
17 Anti-Inflammatory Agents Phase 4
18 Protective Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Post Marketing Surveillance to Evaluate the Safety and Efficacy of Lotemax Ophthalmic Suspension 0.5% Completed NCT01437982 Phase 4 Loteprednol Etabonate;Prednisolone Acetate 1% Oph Susp
2 Comparison Between Nylon and Polyglactin Corneal Suture in Pediatric Cataract Surgery: a Randomized Controlled Clinical Trial Recruiting NCT03812640

Search NIH Clinical Center for Papillary Conjunctivitis

Genetic Tests for Papillary Conjunctivitis

Anatomical Context for Papillary Conjunctivitis

MalaCards organs/tissues related to Papillary Conjunctivitis:

40
Eye, Testes, T Cells, Skin, B Cells, Neutrophil

Publications for Papillary Conjunctivitis

Articles related to Papillary Conjunctivitis:

(show top 50) (show all 355)
# Title Authors PMID Year
1
Giant papillary conjunctivitis: A review. 61
32339665 2020
2
The treatment of recurrent conjunctival and corneal intraepithelial neoplasia with interferon alfa-2b and retinoic acid: ~9 years' follow-up on tumor control. 61
32311432 2020
3
Ocular allergy test and biomarkers on the ocular surface: Clinical test for evaluating the ocular surface condition in allergic conjunctival diseases. 61
32563624 2020
4
Potential Biomarkers for Allergic Conjunctival Diseases. 61
32097185 2020
5
Floppy eyelid syndrome: A comprehensive review. 61
31593763 2020
6
Tear Inflammatory Molecules in Contact Lens Wearers: A Literature Review. 61
30963963 2020
7
Chronic Conjunctivitis From a Retained Contact Lens. 61
30724838 2020
8
Dupilumab-associated blepharoconjunctivitis. 61
31535057 2019
9
Contact lens complications among wearers in Ghana. 61
31784334 2019
10
[Floppy eyelid syndrome : A frequently underdiagnosed entity of interdisciplinary importance]. 61
31641846 2019
11
[Application of corticosteroid eye drops for allergic eye diseases in children]. 61
30798620 2019
12
Resolution of recalcitrant chronic papillary conjunctivitis associated with epiphora following punctoplasty and lacrimal stenting. 61
30119793 2018
13
Lax eyelid syndrome (LES), obstructive sleep apnea (OSA), and ocular surface inflammation. 61
29729418 2018
14
Floppy Eyelid Syndrome: An Unfamiliar Entity for Plastic Surgeons. 61
29369905 2018
15
Surgical treatment outcome of medically refractory huge giant papillary conjunctivitis. 61
29260110 2017
16
[Characteristics of allergic conjunctivitis with positive skin prick test]. 61
28926887 2017
17
In vivo confocal microscopic characteristics of microsporidial keratoconjunctivitis in immunocompetent adults. 61
28130350 2017
18
Japanese guidelines for allergic conjunctival diseases 2017. 61
28209324 2017
19
Contact Lenses for Keratoconus- Current Practice. 61
28932340 2017
20
A retrospective analysis of vision correction and safety in keratoconus patients wearing Toris K soft contact lenses. 61
26895272 2016
21
An update on ocular allergy. 61
27490123 2016
22
Allergic manifestations of contact lens wearing. 61
27518840 2016
23
Combined medial canthopexy and lateral tarsal strip for floppy eyelid syndrome. 61
27178516 2016
24
Changes in the Eye Microbiota Associated with Contact Lens Wearing. 61
27006462 2016
25
[Ocular prosthetics. Fitting, daily use and complications]. 61
26160105 2016
26
[. Oсumethyl in the treatment of allergic diseases of eyelids and conjunctiva]. 61
27911431 2016
27
Botulinum toxin injection into the lacrimal gland for treatment of proximal nasolacrimal duct obstructions in children. 61
25427340 2014
28
Treatment of asymmetrical vernal keratoconjunctivitis with supratarsal corticosteroid injection. 61
25410033 2014
29
Compliance study of contact lens wearers in Japan--part 2: evaluation of a subscribed membership system. 61
25162289 2014
30
[Giant papillary conjunctivitis]. 61
24799171 2014
31
Risk factors for contact lens-induced papillary conjunctivitis associated with silicone hydrogel contact lens wear. 61
24681609 2014
32
Pharmacokinetic evaluation of topical calcineurin inhibitors for treatment of allergic conjunctivitis. 61
24490943 2014
33
Floppy eyelid syndrome as an indicator of the presence of glaucoma in patients with obstructive sleep apnea. 61
23807350 2014
34
A case of recalcitrant bacterial conjunctivitis. 61
24555257 2013
35
Allergic conjunctivitis: an update on diagnosis and management. 61
23974684 2013
36
Adverse events during 2 years of daily wear of silicone hydrogels in children. 61
23939292 2013
37
Ocular complications of soft contact lens wearers in a tertiary eye care centre of Nepal. 61
23238170 2013
38
Ocular physiology and comfort in neophyte subjects fitted with daily disposable silicone hydrogel contact lenses. 61
23279732 2013
39
Allergic conjunctivitis: a comprehensive review of the literature. 61
23497516 2013
40
Mechanical complications induced by silicone hydrogel contact lenses. 61
23271473 2013
41
Treatment of conjunctival and corneal epithelial neoplasia with retinoic acid and topical interferon alfa-2b: long-term follow-up. 61
22704834 2012
42
The clinical performance of lenses disposed of daily can vary considerably. 61
22890226 2012
43
Comparison of tacrolimus, fluorometholone, and saline in mild-to-moderate contact lens-induced papillary conjunctivitis. 61
22821643 2012
44
Diagnostics and new developments in the treatment of ocular allergies. 61
22382607 2012
45
[Evaluation of the efficacy of subjective symptoms, objective findings, and of a total tear IgE detection kit in diagnosis of allergic conjunctival diseases]. 61
22690539 2012
46
[Floppy eyelid syndrome and obstructive sleep apnoea]. 61
22679694 2012
47
Topical interferon alfa-2b for management of ocular surface squamous neoplasia in 23 cases: outcomes based on American Joint Committee on Cancer classification. 61
22332208 2012
48
Advances in corticosteroid therapy for ocular inflammation: loteprednol etabonate. 61
22536546 2012
49
[Follicular conjunctivitis of unknown origin]. 61
22134344 2012
50
Prevalence of contact lens related complications in a tertiary eye centre in India. 61
21795098 2011

Variations for Papillary Conjunctivitis

Expression for Papillary Conjunctivitis

Search GEO for disease gene expression data for Papillary Conjunctivitis.

Pathways for Papillary Conjunctivitis

Pathways related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.87 PRG2 LTF IL7 IL6 IL4 IL11
2
Show member pathways
13.6 PRG2 IL7 IL6 IL4 IL11 CXCL9
3
Show member pathways
13.5 IL7 IL6 IL4 IL11 CXCL9 CXCL8
4
Show member pathways
13.4 IL7 IL6 IL4 IL11 CXCL8 CCL24
5
Show member pathways
13.27 PRG2 CXCL9 CXCL8 CCL24 CCL2 CCL11
6
Show member pathways
13.25 IL7 IL6 IL4 IL11 CXCL8 CCL2
7
Show member pathways
13.12 IL7 IL6 IL4 IL11 CXCL9 CXCL8
8
Show member pathways
12.88 IL7 IL6 IL4 IL11 CXCL9 CXCL8
9
Show member pathways
12.77 CXCL9 CXCL8 CCL24 CCL2 CCL11
10
Show member pathways
12.74 PRG2 IL6 IL4 CXCL9 CXCL8 CCL11
11
Show member pathways
12.34 IL7 IL6 IL4 IL11
12
Show member pathways
12.23 IL6 IL4 CXCL8 CCL2 CCL11
13 12.1 IL6 CXCL8 CCL2
14
Show member pathways
12.09 IL6 IL4 IL11 CXCL8 CCL11
15
Show member pathways
12.07 IL6 CXCL9 CXCL8 CCL24 CCL2 CCL11
16 11.96 IL6 IL4 CXCL8 CCL2
17 11.93 IL7 IL6 IL4 IL11
18 11.91 IL6 CXCL8 CCL2
19 11.86 IL6 IL4 CXCL8 CCL2 CCL11
20 11.84 IL7 IL6 IL4 IL11
21 11.81 IL6 CXCL8 CCL2
22 11.81 IL6 IL11 CXCL8 CCL2
23 11.72 IL6 IL4 CXCL8
24 11.49 IL6 CXCL8 CCL2
25 11.45 IL6 CXCL8 CCL11
26 11.45 IL6 IL4 CXCL8 CCL2
27 11.31 IL6 CXCL8 CCL2
28 11.27 IL7 IL6 IL4
29 11.15 IL6 IL4 CXCL8 CCL2 CCL11
30 11.13 IL7 IL6 IL4 IL11
31 10.94 IL6 CXCL8
32 10.93 CCL2 CCL11
33 10.72 IL6 IL4
34 10.23 PRG2 IL7 IL6 IL4 IL11 CXCL9

GO Terms for Papillary Conjunctivitis

Cellular components related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 LTF IL7 IL6 IL4 IL11 CXCL9
2 extracellular region GO:0005576 9.36 PRG2 LTF IL7 IL6 IL4 IL11

Biological processes related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.11 IL7 IL6 IL4 IL11 CXCL9 CXCL8
2 inflammatory response GO:0006954 9.88 IL6 CXCL9 CXCL8 CCL24 CCL2 CCL11
3 cellular response to lipopolysaccharide GO:0071222 9.84 IL6 CXCL9 CXCL8 CCL2
4 cellular response to tumor necrosis factor GO:0071356 9.81 CXCL8 CCL24 CCL2 CCL11
5 cytoskeleton organization GO:0007010 9.79 CCL24 CCL2 CCL11
6 regulation of cell shape GO:0008360 9.78 CCL24 CCL2 CCL11
7 cellular response to interleukin-1 GO:0071347 9.78 CXCL8 CCL24 CCL2 CCL11
8 positive regulation of angiogenesis GO:0045766 9.77 CXCL8 CCL24 CCL11
9 chemotaxis GO:0006935 9.77 CXCL9 CXCL8 CCL24 CCL2 CCL11
10 cellular response to interferon-gamma GO:0071346 9.73 CCL24 CCL2 CCL11
11 humoral immune response GO:0006959 9.73 LTF IL7 IL6 CCL2
12 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.72 LTF CXCL9 CXCL8
13 lymphocyte chemotaxis GO:0048247 9.7 CCL24 CCL2 CCL11
14 eosinophil chemotaxis GO:0048245 9.67 CCL24 CCL2 CCL11
15 neutrophil chemotaxis GO:0030593 9.65 CXCL9 CXCL8 CCL24 CCL2 CCL11
16 innate immune response in mucosa GO:0002227 9.62 LTF IL4
17 monocyte chemotaxis GO:0002548 9.62 IL6 CCL24 CCL2 CCL11
18 leukocyte chemotaxis GO:0030595 9.61 CXCL9 CXCL8
19 positive regulation of T cell differentiation GO:0045582 9.6 IL7 IL4
20 positive regulation of myoblast fusion GO:1901741 9.58 IL4 CXCL9
21 positive regulation of chemokine production GO:0032722 9.58 IL7 IL6
22 PERK-mediated unfolded protein response GO:0036499 9.57 CXCL8 CCL2
23 chemokine-mediated signaling pathway GO:0070098 9.55 CXCL9 CXCL8 CCL24 CCL2 CCL11
24 cytokine-mediated signaling pathway GO:0019221 9.5 IL7 IL6 IL4 IL11 CXCL8 CCL2
25 immune response GO:0006955 9.32 PRG2 LAX1 IL7 IL6 IL4 CXCL9

Molecular functions related to Papillary Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.56 IL7 IL6 IL4 IL11
2 CXCR chemokine receptor binding GO:0045236 9.37 CXCL9 CXCL8
3 chemokine activity GO:0008009 9.35 CXCL9 CXCL8 CCL24 CCL2 CCL11
4 CCR chemokine receptor binding GO:0048020 9.33 CCL24 CCL2 CCL11
5 CCR3 chemokine receptor binding GO:0031728 9.32 CCL24 CCL11
6 cytokine activity GO:0005125 9.28 IL7 IL6 IL4 IL11 CXCL9 CXCL8

Sources for Papillary Conjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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