MCID: PPL009
MIFTS: 30

Papillary Craniopharyngioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Papillary Craniopharyngioma

MalaCards integrated aliases for Papillary Craniopharyngioma:

Name: Papillary Craniopharyngioma 12 15 17 74
Papillary Rathke's Pouch Tumor 12
Craniopharyngioma, Papillary 12
Craniopharyngioma Papillary 56

Classifications:



External Ids:

Disease Ontology 12 DOID:3847
MeSH 45 D003397
NCIt 51 C4725
UMLS 74 C0431128

Summaries for Papillary Craniopharyngioma

MalaCards based summary : Papillary Craniopharyngioma, also known as papillary rathke's pouch tumor, is related to craniopharyngioma and cystadenoma, and has symptoms including visual disturbance An important gene associated with Papillary Craniopharyngioma is CTNNB1 (Catenin Beta 1), and among its related pathways/superpathways are Glioblastoma Multiforme and Corticotropin-releasing hormone signaling pathway. The drugs Vemurafenib and Protein Kinase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include pituitary and colon.

Related Diseases for Papillary Craniopharyngioma

Diseases related to Papillary Craniopharyngioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 craniopharyngioma 30.7 BRAF CTNNB1 KRT7
2 cystadenoma 10.6
3 colonic benign neoplasm 10.1 BRAF CTNNB1
4 metanephric adenoma 10.1 BRAF KRT7
5 large intestine adenocarcinoma 10.1 CTNNB1 KRT7
6 lung acinar adenocarcinoma 10.1 CTNNB1 KRT7
7 adenomyoma 10.1 CTNNB1 KRT7
8 bladder adenocarcinoma 10.1 CTNNB1 KRT7
9 female reproductive endometrioid cancer 10.1 CTNNB1 KRT7
10 pulmonary sclerosing hemangioma 10.1 CTNNB1 KRT7
11 sclerosing hemangioma 10.1 CTNNB1 KRT7
12 acinar cell carcinoma 10.1 CTNNB1 KRT7
13 cystitis cystica 10.1 CTNNB1 KRT7
14 gastrointestinal system benign neoplasm 10.1 CTNNB1 KRT7
15 papillary carcinoma 10.1 BRAF KRT7
16 rectum adenocarcinoma 10.0 DNAH12 KRT7
17 cell type benign neoplasm 10.0 CTNNB1 KRT7
18 carcinosarcoma 10.0 CTNNB1 KRT7
19 sarcoma, synovial 10.0 CTNNB1 KRT7
20 renal cell carcinoma, papillary, 1 10.0 BRAF KRT7
21 endometrial adenocarcinoma 10.0 CTNNB1 KRT7
22 intrahepatic cholangiocarcinoma 10.0 CTNNB1 KRT7
23 hepatoblastoma 10.0 CTNNB1 KRT7
24 suppression of tumorigenicity 12 10.0 BRAF CTNNB1
25 gastrointestinal system cancer 10.0 CTNNB1 KRT7
26 colorectal adenocarcinoma 9.9 BRAF CTNNB1 KRT7
27 bladder urothelial carcinoma 9.9 BRAF CTNNB1 KRT7
28 cholangiocarcinoma 9.9 BRAF CTNNB1 KRT7
29 transitional cell carcinoma 9.9 BRAF KRT7
30 large intestine cancer 9.8 BRAF CTNNB1 KRT7
31 gastric adenocarcinoma 9.8 BRAF CTNNB1 KRT7
32 lung cancer susceptibility 3 9.8 BRAF CTNNB1 KRT7
33 adrenocortical carcinoma, hereditary 9.8 BRAF CTNNB1
34 endometrial cancer 9.7 BRAF CTNNB1 KRT7
35 adamantinous craniopharyngioma 9.3 CTNNB1 DNAH12 DNAH2 DNAH7

Graphical network of the top 20 diseases related to Papillary Craniopharyngioma:



Diseases related to Papillary Craniopharyngioma

Symptoms & Phenotypes for Papillary Craniopharyngioma

UMLS symptoms related to Papillary Craniopharyngioma:


visual disturbance

Drugs & Therapeutics for Papillary Craniopharyngioma

Drugs for Papillary Craniopharyngioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vemurafenib Approved Phase 2 918504-65-1 23252090 42611257
2 Protein Kinase Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vemurafenib and Cobimetinib in Treating Patients With BRAF V600E Mutation Positive Craniopharyngioma Recruiting NCT03224767 Phase 2 Vemurafenib;Cobimetinib

Search NIH Clinical Center for Papillary Craniopharyngioma

Genetic Tests for Papillary Craniopharyngioma

Anatomical Context for Papillary Craniopharyngioma

MalaCards organs/tissues related to Papillary Craniopharyngioma:

42
Pituitary, Colon

Publications for Papillary Craniopharyngioma

Articles related to Papillary Craniopharyngioma:

(show all 26)
# Title Authors Year
1
Papillary craniopharyngioma in a 4-year-old girl with BRAF V600E mutation: a case report and review of the literature. ( 30069716 )
2019
2
Rathke's Cleft Cyst as Origin of a Pediatric Papillary Craniopharyngioma. ( 29520296 )
2018
3
Recurrent papillary craniopharyngioma with BRAF V600E mutation treated with dabrafenib: case report. ( 29701552 )
2018
4
Recurrent papillary craniopharyngioma with BRAFV600E mutation treated with neoadjuvant-targeted therapy. ( 28918496 )
2017
5
Genomic Alterations of Adamantinomatous and Papillary Craniopharyngioma. ( 28069929 )
2017
6
BRAF-V600E mutant papillary craniopharyngioma dramatically responds to combination BRAF and MEK inhibitors. ( 28425764 )
2017
7
Anorexia-cachexia syndrome-like hypothalamic neuroendocrine dysfunction in a patient with a papillary craniopharyngioma. ( 28469924 )
2017
8
Papillary craniopharyngioma: A clinicopathologic study of a rare entity from a major tertiary care center in Pakistan. ( 28488624 )
2017
9
MAPK pathway control of stem cell proliferation and differentiation in the embryonic pituitary provides insights into the pathogenesis of papillary craniopharyngioma. ( 28506993 )
2017
10
Pronounced response of papillary craniopharyngioma to treatment with vemurafenib, a BRAF inhibitor. ( 26115708 )
2016
11
Dramatic Response of BRAF V600E Mutant Papillary Craniopharyngioma to Targeted Therapy. ( 26498373 )
2016
12
ENDOCRINE TUMORS: BRAF V600E mutations in papillary craniopharyngioma. ( 26563980 )
2016
13
BRAF V600E mutation is a useful marker for differentiating Rathke's cleft cyst with squamous metaplasia from papillary craniopharyngioma. ( 25820214 )
2015
14
Pretreatment diagnosis of suprasellar papillary craniopharyngioma and germ cell tumors of adult patients. ( 25339645 )
2015
15
BRAF V600E mutations are characteristic for papillary craniopharyngioma and may coexist with CTNNB1-mutated adamantinomatous craniopharyngioma. ( 24715106 )
2014
16
Primary isolated cerebellopontine angle papillary craniopharyngioma. ( 22954990 )
2012
17
Intraventricular squamous papillary craniopharyngioma: report of a case with intraoperative imprint cytology. ( 16124175 )
2005
18
Metastatic papillary craniopharyngioma: case study and study of tumor angiogenesis. ( 11916504 )
2002
19
Suprasellar squamous papillary craniopharyngioma: a case report. ( 11394840 )
2001
20
SUPRASELLAR PAPILLARY SQUAMOUS EPITHELIOMA (PAPILLARY CRANIOPHARYNGIOMA): Reply. ( 27407336 )
2001
21
SUPRASELLAR PAPILLARY SQUAMOUS EPITHELIOMA (PAPILLARY CRANIOPHARYNGIOMA). ( 27407338 )
2001
22
SUPRASELLAR PAPILLARY SQUAMOUS EPITHELIOMA (PAPILLARY CRANIOPHARYNGIOMA). ( 28790684 )
2000
23
Regression of a large solid papillary craniopharyngioma following fractionated external radiotherapy. ( 10359146 )
1999
24
Papillary craniopharyngioma: a clinicopathological study of 48 cases. ( 7616262 )
1995
25
Papillary craniopharyngioma of the third ventricle--case report. ( 1283625 )
1992
26
Suprasellar papillary squamous epithelioma ("papillary craniopharyngioma"). ( 6696166 )
1984

Variations for Papillary Craniopharyngioma

Expression for Papillary Craniopharyngioma

Search GEO for disease gene expression data for Papillary Craniopharyngioma.

Pathways for Papillary Craniopharyngioma

Pathways related to Papillary Craniopharyngioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11 BRAF CTNNB1
2 10.59 BRAF CTNNB1

GO Terms for Papillary Craniopharyngioma

Cellular components related to Papillary Craniopharyngioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.88 BRAF CTNNB1 DNAH12 DNAH2 DNAH7 KRT7
2 cytoskeleton GO:0005856 9.67 CTNNB1 DNAH12 DNAH2 DNAH7
3 microtubule GO:0005874 9.5 DNAH12 DNAH2 DNAH7
4 cell projection GO:0042995 9.46 CTNNB1 DNAH12 DNAH2 DNAH7
5 cilium GO:0005929 9.43 DNAH12 DNAH2 DNAH7
6 axonemal dynein complex GO:0005858 8.96 DNAH2 DNAH7
7 dynein complex GO:0030286 8.8 DNAH12 DNAH2 DNAH7

Biological processes related to Papillary Craniopharyngioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 thymus development GO:0048538 9.16 BRAF CTNNB1
2 cilium-dependent cell motility GO:0060285 8.96 DNAH2 DNAH7
3 microtubule-based movement GO:0007018 8.8 DNAH12 DNAH2 DNAH7

Molecular functions related to Papillary Craniopharyngioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.71 BRAF DNAH12 DNAH2 DNAH7
2 dynein intermediate chain binding GO:0045505 9.37 DNAH2 DNAH7
3 dynein light intermediate chain binding GO:0051959 9.32 DNAH2 DNAH7
4 dynein light chain binding GO:0045503 9.26 DNAH2 DNAH7
5 ATP-dependent microtubule motor activity, minus-end-directed GO:0008569 9.16 DNAH2 DNAH7
6 motor activity GO:0003774 9.13 DNAH12 DNAH2 DNAH7
7 microtubule motor activity GO:0003777 8.8 DNAH12 DNAH2 DNAH7

Sources for Papillary Craniopharyngioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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