MCID: PPL013
MIFTS: 30

Papillary Ependymoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Papillary Ependymoma

MalaCards integrated aliases for Papillary Ependymoma:

Name: Papillary Ependymoma 12 6 15 70
Ependymoma Papillary 54

Classifications:



External Ids:

Disease Ontology 12 DOID:5505
MeSH 44 D004806
NCIt 50 C4319
SNOMED-CT 67 112686007
UMLS 70 C0334578

Summaries for Papillary Ependymoma

MalaCards based summary : Papillary Ependymoma, also known as ependymoma papillary, is related to cellular ependymoma and benign ependymoma. An important gene associated with Papillary Ependymoma is MEN1 (Menin 1), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include spinal cord, pineal and brain, and related phenotype is Increased proliferation.

Related Diseases for Papillary Ependymoma

Diseases related to Papillary Ependymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 157)
# Related Disease Score Top Affiliating Genes
1 cellular ependymoma 30.7 SYP S100B NF2 MEN1 GFAP
2 benign ependymoma 30.4 SYP NF2 GFAP
3 pineal gland cancer 29.8 SYP GFAP
4 pineoblastoma 29.8 SYP GFAP
5 rhabdoid meningioma 29.5 SYP NF2 GFAP
6 pineocytoma 29.2 SYP S100B GFAP
7 papilloma of choroid plexus 29.0 TTR SYP S100B GFAP
8 anaplastic ependymoma 28.9 SYP S100B NF2 GFAP
9 hydrocephalus 28.8 TTR SYP S100B GFAP
10 meningioma, familial 28.5 SYP S100B NF2 MEN1 GFAP
11 spinal cord ependymoma 10.2 NF2 MEN1
12 pediatric ependymoma 10.1 NF2 MEN1
13 suprasellar meningioma 10.1 NF2 GFAP
14 amyloid tumor 10.1 TTR NF2
15 frontal convexity meningioma 10.1 NF2 GFAP
16 gastrointestinal neuroendocrine benign tumor 10.1 SYP MEN1
17 gastric neuroendocrine neoplasm 10.1 SYP MEN1
18 pancreatic gastrinoma 10.1 SYP MEN1
19 high grade ependymoma 10.1 NF2 GFAP
20 gastrointestinal neuroendocrine tumor 10.1 SYP MEN1
21 carcinoid tumors, intestinal 10.1 SYP MEN1
22 carcinoid syndrome 10.1 SYP MEN1
23 small intestine benign neoplasm 10.1 SYP MEN1
24 lung meningioma 10.1 SYP NF2
25 pulmonary neuroendocrine tumor 10.1 SYP MEN1
26 orbital cancer 10.0 SYP NF2
27 pancreatic endocrine carcinoma 10.0 SYP MEN1
28 squamous cell papilloma 10.0
29 papilloma 10.0
30 extraventricular neurocytoma 10.0 SYP GFAP
31 desmoplastic infantile ganglioglioma 10.0 SYP GFAP
32 cerebral neuroblastoma 10.0 SYP GFAP
33 thyroid gland medullary carcinoma 10.0 SYP MEN1
34 lung combined type small cell carcinoma 10.0 SYP GFAP
35 cerebellopontine angle primitive neuroectodermal tumor 10.0 SYP GFAP
36 subependymoma 10.0 SYP GFAP
37 chiari malformation 10.0 SYP GFAP
38 pancreatic cystadenoma 10.0 SYP MEN1
39 medullomyoblastoma 10.0 SYP GFAP
40 spinal cord oligodendroglioma 10.0 SYP GFAP
41 endobronchial leiomyoma 10.0 SYP GFAP
42 cauda equina syndrome 10.0 SYP GFAP
43 adrenal cortex disease 10.0 SYP MEN1
44 binswanger's disease 10.0 SYP GFAP
45 adrenal cortical adenoma 10.0 SYP MEN1
46 cerebellum cancer 10.0 SYP GFAP
47 olfactory nerve neoplasm 10.0 SYP GFAP
48 cranial nerve malignant neoplasm 10.0 SYP GFAP
49 cerebellar medulloblastoma 10.0 SYP GFAP
50 gangliocytoma 10.0 SYP GFAP

Graphical network of the top 20 diseases related to Papillary Ependymoma:



Diseases related to Papillary Ependymoma

Symptoms & Phenotypes for Papillary Ependymoma

GenomeRNAi Phenotypes related to Papillary Ependymoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 MEN1 NF2

Drugs & Therapeutics for Papillary Ependymoma

Search Clinical Trials , NIH Clinical Center for Papillary Ependymoma

Genetic Tests for Papillary Ependymoma

Anatomical Context for Papillary Ependymoma

MalaCards organs/tissues related to Papillary Ependymoma:

40
Spinal Cord, Pineal, Brain, Lung, Pituitary, Cortex, Cerebellum

Publications for Papillary Ependymoma

Articles related to Papillary Ependymoma:

(show all 40)
# Title Authors PMID Year
1
Histological spectrum of ependymomas and correlation of p53 and Ki-67 expression with ependymoma grade and subtype. 61 54
15318011 2004
2
Cauda equina tumor with ependymal and paraganglionic differentiation. 61 54
1612583 1992
3
Clinical Image of a Spinal Ependymoma Discovered 8 Years after Initial Misdiagnosis as an Idiopathic Syringomyelia. 61
33022432 2021
4
Posterior fossa ependymoma with preoperative cerebrospinal metastases: a case report with literature review. 61
33300386 2020
5
Molecular characterization of histopathological ependymoma variants. 61
31679042 2020
6
Papillary Ependymoma of the Spinal Cord: A Case Report with Summary of Prior Published Cases. 61
30937039 2019
7
A mixed choroid plexus papilloma and ependymoma. 61
26670168 2016
8
Clinicopathologic study of endolymphatic sac tumor (ELST) and differential diagnosis of papillary tumors located at the cerebellopontine angle. 61
25944396 2015
9
Primary cerebellopontine angle ependymoma with spinal metastasis in an adult patient: A case report. 61
26622745 2015
10
Papillary tumor of the pineal region: Histopathological characterization and review of the literature. 61
24556386 2015
11
Papillary ependymoma of the endometrium. 61
24845054 2014
12
Cytodiagnosis of Sacral Chordoma. 61
26982902 2014
13
Management of low-grade third ventricular ependymomas in adults by endoscopic biopsy followed by gamma knife radiosurgery. 61
24357071 2014
14
Ependymoma with "granular cell" features: report of two cases. 61
22369487 2012
15
Papillary ependymoma of the lateral ventricle: a rare low-grade variant of an uncommon neoplasm in the adult. 61
22295324 2011
16
Melanotic choroid plexus carcinoma of the posterior fossa. 61
21779301 2011
17
Histopathological patterns of papillary tumour of the pineal region. 61
22101951 2011
18
Intramedullary papillary ependymoma with choroid plexus differentiation and cerebrospinal fluid dissemination to the brain. 61
20433266 2010
19
[Choroid plexus carcinoma: a case report]. 61
18804822 2009
20
Papillary ependymoma with unique superficial cortical location: immunohistochemical and ultrastructural studies. A case report. 61
20054788 2009
21
Papillary Ependymoma WHO Grade II of the Aqueduct Treated by Endoscopic Tumor Resection. 61
19724655 2009
22
Clinicopathological features from long-term observation of a papillary tumor of the pineal region (PTPR): a case report. 61
19856220 2009
23
Metastasis of a histologically benign choroid plexus papilloma: case report and review of the literature. 61
17387433 2007
24
[Own experience in surgical treatment of the pineal region and midbrain tumors via the infratentorial approach]. 61
14558493 2003
25
A case of angioglioma composed of astrocytoma with a papillary growth pattern: immunohistochemical and ultrastructural studies. 61
12622143 2002
26
Papillary ependymoma: its differential diagnosis from choroid plexus papilloma. 61
8934397 1996
27
Equine papillary ependymoma. 61
8826009 1996
28
Myxo-papillary ependymoma: an unusual cause of a pelvic mass. 61
7926068 1994
29
Cytologic features of ependymomas in smear preparations. 61
8191821 1994
30
S-antigen immunoreactivity in tumors of the choroid plexus. 61
22823012 1994
31
Choroid plexus papilloma. Report of a case with cytologic differential diagnosis. 61
1312286 1992
32
[Immunohistochemical study for choroid plexus papillomas and ependymomas]. 61
1726244 1991
33
Papillary ependymoma of the cervical spinal cord. 61
2927592 1989
34
Induction of papillary ependymomas and insulinomas in the Syrian golden hamster by BK virus, a human papovavirus. 61
191323 1976
35
[Trabeculary-papillary ependymoma in the sacrococcygeal region]. 61
4466216 1974
36
Subcutaneous myxo-papillary ependymoma of the sacrococcygeal region. 61
5728921 1968
37
[Autopsy case of papillary ependymoma arising from the region of the cauda equina and metastasizing to other organs]. 61
6072043 1967
38
[Myxo-papillary ependymoma of the cauda equina. Clinical and histopathological considerations]. 61
5874553 1965
39
[ENCEPHALITIC SYMPATOMATOLOGY DUE TO PAPILLARY EPENDYMOMA OF THE 3RD VENTRICLE]. 61
14326384 1965
40
[A CASE OF MYXO-PAPILLARY EPENDYMOMA]. 61
14052958 1963

Variations for Papillary Ependymoma

ClinVar genetic disease variations for Papillary Ependymoma:

6 (show all 35)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 MEN1 NM_001370259.2(MEN1):c.696dup (p.Lys233fs) Duplication Pathogenic 487778 rs1555165565 GRCh37: 11:64575111-64575111
GRCh38: 11:64807638-64807639
2 overlap with 76 genes dup(11)(q13.1q13.1) Duplication Likely pathogenic 634998 GRCh37: 11:63533279-65429676
GRCh38:
3 NF2 NM_000268.4(NF2):c.551G>A (p.Trp184Ter) SNV Likely pathogenic 487796 rs1555993293 GRCh37: 22:30051617-30051617
GRCh38: 22:29655628-29655628
4 HSD3B2 NM_000198.4(HSD3B2):c.1004G>A (p.Arg335Gln) SNV Uncertain significance 487802 rs985808078 GRCh37: 1:119965128-119965128
GRCh38: 1:119422505-119422505
5 KREMEN2 NM_172229.3(KREMEN2):c.494G>T (p.Gly165Val) SNV Uncertain significance 487788 rs1210829529 GRCh37: 16:3016650-3016650
GRCh38: 16:2966649-2966649
6 POU3F4 NM_000307.5(POU3F4):c.1013C>T (p.Pro338Leu) SNV Uncertain significance 487785 rs1555984638 GRCh37: X:82764345-82764345
GRCh38: X:83509337-83509337
7 SYNE1 NM_182961.4(SYNE1):c.11097C>G (p.Phe3699Leu) SNV Uncertain significance 487805 rs1554520414 GRCh37: 6:152674554-152674554
GRCh38: 6:152353419-152353419
8 BANP NM_079837.3(BANP):c.575A>G (p.Asn192Ser) SNV Uncertain significance 487782 rs1555586650 GRCh37: 16:88052070-88052070
GRCh38: 16:88018464-88018464
9 SH3TC2 NM_024577.3(SH3TC2):c.3016del (p.Ser1006fs) Deletion Uncertain significance 487808 rs1554121513 GRCh37: 5:148406172-148406172
GRCh38: 5:149026609-149026609
10 SPRY3 NM_005840.2(SPRY3):c.55C>T (p.Arg19Cys) SNV Uncertain significance 487791 rs779201129 GRCh37: Y:59106594-59106594
GRCh38: X:155773926-155773926
11 OTUD5 NM_001136157.2(OTUD5):c.1687C>A (p.Pro563Thr) SNV Uncertain significance 487794 rs1295653938 GRCh37: X:48780465-48780465
GRCh38: X:48923188-48923188
12 GLB1 NM_000404.4(GLB1):c.1903G>C (p.Ala635Pro) SNV Uncertain significance 487803 rs1553604701 GRCh37: 3:33038668-33038668
GRCh38: 3:32997176-32997176
13 HDAC3 NM_003883.4(HDAC3):c.50_55+5del Deletion Uncertain significance 487780 rs1554218152 GRCh37: 5:141016298-141016308
GRCh38: 5:141636731-141636741
14 LETM1 NM_012318.3(LETM1):c.286G>A (p.Val96Met) SNV Uncertain significance 487800 rs753905629 GRCh37: 4:1843382-1843382
GRCh38: 4:1841655-1841655
15 LATS1 NM_004690.4(LATS1):c.2365G>C (p.Asp789His) SNV Uncertain significance 487797 rs750318192 GRCh37: 6:150001239-150001239
GRCh38: 6:149680103-149680103
16 ADGRA2 NM_032777.10(ADGRA2):c.1316_1334del (p.Asn439fs) Deletion Uncertain significance 487806 rs1554525957 GRCh37: 8:37691223-37691241
GRCh38: 8:37833705-37833723
17 SUV39H1 NM_003173.4(SUV39H1):c.415C>T (p.Arg139Cys) SNV Uncertain significance 487783 rs368779259 GRCh37: X:48558731-48558731
GRCh38: X:48700340-48700340
18 SLC39A11 NM_139177.4(SLC39A11):c.595G>T (p.Val199Phe) SNV Uncertain significance 487809 rs745762301 GRCh37: 17:70845779-70845779
GRCh38: 17:72849640-72849640
19 DEPDC5 NM_001242897.2(DEPDC5):c.2705G>A (p.Trp902Ter) SNV Uncertain significance 487789 rs1555900957 GRCh37: 22:32241141-32241141
GRCh38: 22:31845155-31845155
20 PATZ1 NM_014323.3(PATZ1):c.562G>T (p.Asp188Tyr) SNV Uncertain significance 487786 rs1555894069 GRCh37: 22:31741027-31741027
GRCh38: 22:31345041-31345041
21 RET NM_020975.6(RET):c.1202G>A (p.Ser401Asn) SNV Uncertain significance 620604 rs1564493414 GRCh37: 10:43604617-43604617
GRCh38: 10:43109169-43109169
22 MAP4K3 NM_003618.4(MAP4K3):c.899T>C (p.Phe300Ser) SNV Uncertain significance 487798 rs1268580645 GRCh37: 2:39552678-39552678
GRCh38: 2:39325537-39325537
23 KLHL21 NM_014851.4(KLHL21):c.501G>C (p.Glu167Asp) SNV Uncertain significance 487795 rs1292721663 GRCh37: 1:6662377-6662377
GRCh38: 1:6602317-6602317
24 VBP1 NM_003372.7(VBP1):c.331C>A (p.Leu111Met) SNV Uncertain significance 487792 rs1000821034 GRCh37: X:154456711-154456711
GRCh38: X:155228429-155228429
25 TASOR NM_001365635.2(TASOR):c.97G>A (p.Glu33Lys) SNV Uncertain significance 487784 rs1553733337 GRCh37: 3:56716938-56716938
GRCh38: 3:56682910-56682910
26 MT-ND4 NC_012920.1:m.11032delA Deletion Uncertain significance 487804 rs1556423884 GRCh37: MT:11032-11032
GRCh38: MT:11032-11032
27 SETD9 NM_153706.4(SETD9):c.788_796del (p.Ile263_Tyr265del) Deletion Uncertain significance 487781 rs1554039146 GRCh37: 5:56210766-56210774
GRCh38: 5:56914939-56914947
28 TXNRD2 NM_006440.5(TXNRD2):c.1432G>C (p.Ala478Pro) SNV Uncertain significance 487801 rs1555906972 GRCh37: 22:19865626-19865626
GRCh38: 22:19878103-19878103
29 DUSP29 , KAT6B NM_012330.4(KAT6B):c.3827C>T (p.Pro1276Leu) SNV Uncertain significance 487787 rs1554845417 GRCh37: 10:76788409-76788409
GRCh38: 10:75028651-75028651
30 TRPM1 NM_001252024.2(TRPM1):c.283A>C (p.Ile95Leu) SNV Uncertain significance 487810 rs1555424877 GRCh37: 15:31360292-31360292
GRCh38: 15:31068089-31068089
31 CACNG2 NM_006078.4(CACNG2):c.541T>C (p.Tyr181His) SNV Uncertain significance 487807 rs1555892196 GRCh37: 22:36960829-36960829
GRCh38: 22:36564782-36564782
32 NET1 NM_001047160.3(NET1):c.498G>T (p.Glu166Asp) SNV Uncertain significance 487790 rs1554818513 GRCh37: 10:5494455-5494455
GRCh38: 10:5452492-5452492
33 ARHGAP32 NM_014715.4(ARHGAP32):c.3656C>G (p.Thr1219Ser) SNV Uncertain significance 487793 rs749174548 GRCh37: 11:128840363-128840363
GRCh38: 11:128970468-128970468
34 GON4L NM_032292.6(GON4L):c.2455A>G (p.Asn819Asp) SNV Uncertain significance 487779 rs1553200563 GRCh37: 1:155742897-155742897
GRCh38: 1:155773106-155773106
35 TRAF3 NM_003300.4(TRAF3):c.53C>G (p.Pro18Arg) SNV Uncertain significance 487799 rs145456077 GRCh37: 14:103336591-103336591
GRCh38: 14:102870254-102870254

Expression for Papillary Ependymoma

Search GEO for disease gene expression data for Papillary Ependymoma.

Pathways for Papillary Ependymoma

Pathways related to Papillary Ependymoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 SYP S100B NF2 GFAP
2 11.03 SYP S100B GFAP

GO Terms for Papillary Ependymoma

Cellular components related to Papillary Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell body GO:0044297 8.96 NF2 GFAP
2 cleavage furrow GO:0032154 8.62 NF2 MEN1

Molecular functions related to Papillary Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 8.92 TTR SYP S100B GFAP

Sources for Papillary Ependymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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