MCID: PPL013
MIFTS: 29

Papillary Ependymoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Papillary Ependymoma

MalaCards integrated aliases for Papillary Ependymoma:

Name: Papillary Ependymoma 12 15 73
Ependymoma Papillary 55

Classifications:



External Ids:

Disease Ontology 12 DOID:5505
MeSH 44 D004806
NCIt 50 C4319
UMLS 73 C0334578

Summaries for Papillary Ependymoma

MalaCards based summary : Papillary Ependymoma, also known as ependymoma papillary, is related to ependymoma and papilloma of choroid plexus. An important gene associated with Papillary Ependymoma is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways are Neuroscience and Cytoskeleton remodeling Neurofilaments. The drugs Vincristine and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and skin.

Related Diseases for Papillary Ependymoma

Diseases related to Papillary Ependymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 239)
# Related Disease Score Top Affiliating Genes
1 ependymoma 32.1 ENO2 GFAP NES S100B SYP TTR
2 papilloma of choroid plexus 29.9 GFAP S100B SYP TTR
3 obstructive hydrocephalus 10.3 GFAP SYP
4 cerebellopontine angle tumor 10.3 GFAP SYP
5 pilomyxoid astrocytoma 10.3 GFAP SYP
6 syringoma 10.3 GFAP S100B
7 spindle cell rhabdomyosarcoma 10.3 GFAP S100B
8 chordoid glioma 10.3 GFAP S100B
9 ectopic cushing syndrome 10.3 S100B SYP
10 myxopapillary ependymoma 10.3 GFAP S100B
11 supratentorial primitive neuroectodermal tumor 10.3 S100B SYP
12 rosette-forming glioneuronal tumor 10.3 S100B SYP
13 ileum cancer 10.3 ENO2 GFAP
14 seminal vesicle tumor 10.3 KRT18 SYP
15 schneiderian carcinoma 10.3 KRT18 SYP
16 microcystic meningioma 10.3 ENO2 GFAP
17 bone benign neoplasm 10.3 ENO2 SYP
18 connective tissue benign neoplasm 10.3 ENO2 SYP
19 dysgerminoma of ovary 10.3 ENO2 GFAP
20 mixed cell type cancer 10.3 ENO2 SYP
21 glomus tumor 10.3 ENO2 SYP
22 juvenile pilocytic astrocytoma 10.3 ENO2 GFAP
23 mucinous ovarian cystadenoma 10.3 ENO2 SYP
24 rhabdoid cancer 10.3 ENO2 SYP
25 angiomyoma 10.3 ENO2 SYP
26 microglandular adenosis 10.3 KRT18 S100B
27 extraosseous chondrosarcoma 10.3 ENO2 SYP
28 intraocular retinoblastoma 10.3 ENO2 SYP
29 malignant teratoma 10.3 ENO2 SYP
30 spondylosis 10.3 ENO2 S100B
31 endometrial small cell carcinoma 10.3 ENO2 SYP
32 prostate small cell carcinoma 10.3 ENO2 SYP
33 meningeal melanomatosis 10.3 ENO2 SYP
34 desmoplastic small round cell tumor 10.3 ENO2 SYP
35 extraskeletal ewing sarcoma 10.3 ENO2 SYP
36 head injury 10.3 ENO2 S100B
37 purulent endophthalmitis 10.3 SAG SYP
38 retinal hemangioblastoma 10.3 ENO2 KRT18
39 choroid plexus cancer 10.3 GFAP TTR
40 desmoplastic infantile ganglioglioma 10.3 GFAP SYP
41 extraventricular neurocytoma 10.3 GFAP SYP
42 brown-sequard syndrome 10.3 GFAP TTR
43 ganglioneuroblastoma 10.3 ENO2 SYP
44 lung combined type small cell carcinoma 10.2 GFAP SYP
45 immune system organ benign neoplasm 10.2 KRT8 SYP
46 thymus lipoma 10.2 KRT8 SYP
47 atypical choroid plexus papilloma 10.2 KRT8 SYP
48 cancer-associated retinopathy 10.2 ENO2 SAG
49 dysentery 10.2 ENO2 TTR
50 carotid body cancer 10.2 ENO2 SYP

Graphical network of the top 20 diseases related to Papillary Ependymoma:



Diseases related to Papillary Ependymoma

Symptoms & Phenotypes for Papillary Ependymoma

Drugs & Therapeutics for Papillary Ependymoma

Drugs for Papillary Ependymoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
2
Cyclophosphamide Approved, Investigational Phase 3 6055-19-2, 50-18-0 2907
3
Carboplatin Approved Phase 3 41575-94-4 10339178 38904 498142
4
Etoposide Approved Phase 3 33419-42-0 36462
5
Cisplatin Approved Phase 3 15663-27-1 2767 441203 84093
6 Antineoplastic Agents, Alkylating Phase 3
7 Keratolytic Agents Phase 3
8 Alkylating Agents Phase 3
9 Antineoplastic Agents, Phytogenic Phase 3
10 Podophyllotoxin Phase 3 518-28-5
11 Immunologic Factors Phase 3
12 Antirheumatic Agents Phase 3
13 Antimitotic Agents Phase 3
14 Etoposide phosphate Phase 3
15 Topoisomerase Inhibitors Phase 3
16 Immunosuppressive Agents Phase 3
17 Dermatologic Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Maintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Ependymoma Recruiting NCT01096368 Phase 3 Carboplatin;Cisplatin;Cyclophosphamide;Etoposide;Vincristine Sulfate Liposome

Search NIH Clinical Center for Papillary Ependymoma

Genetic Tests for Papillary Ependymoma

Anatomical Context for Papillary Ependymoma

MalaCards organs/tissues related to Papillary Ependymoma:

41
Brain, Lung, Skin, Liver, Ovary, Cervix, Pineal

Publications for Papillary Ependymoma

Articles related to Papillary Ependymoma:

# Title Authors Year
1
Papillary ependymoma of the endometrium. ( 24845054 )
2014
2
Papillary ependymoma of the lateral ventricle: a rare low-grade variant of an uncommon neoplasm in the adult. ( 22295324 )
2011
3
Intramedullary papillary ependymoma with choroid plexus differentiation and cerebrospinal fluid dissemination to the brain. ( 20433266 )
2010
4
Papillary Ependymoma WHO Grade II of the Aqueduct Treated by Endoscopic Tumor Resection. ( 19724655 )
2009
5
Papillary ependymoma with unique superficial cortical location: immunohistochemical and ultrastructural studies. A case report. ( 20054788 )
2009
6
Papillary ependymoma: its differential diagnosis from choroid plexus papilloma. ( 8934397 )
1996
7
Equine papillary ependymoma. ( 8826009 )
1996
8
Myxo-papillary ependymoma: an unusual cause of a pelvic mass. ( 7926068 )
1994
9
Papillary ependymoma of the cervical spinal cord. ( 2927592 )
1989
10
Subcutaneous myxo-papillary ependymoma of the sacrococcygeal region. ( 5728921 )
1968

Variations for Papillary Ependymoma

Expression for Papillary Ependymoma

Search GEO for disease gene expression data for Papillary Ependymoma.

Pathways for Papillary Ependymoma

Pathways related to Papillary Ependymoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.63 ENO2 GFAP RBFOX3 S100B SAG SYP
2
Show member pathways
11.49 GFAP KRT18 KRT8 NES
3 11.15 GFAP NES S100B SYP

GO Terms for Papillary Ependymoma

Cellular components related to Papillary Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament cytoskeleton GO:0045111 9.13 GFAP KRT8 NES
2 intermediate filament GO:0005882 8.92 GFAP KRT18 KRT8 NES

Biological processes related to Papillary Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of neuronal synaptic plasticity GO:0048168 8.96 S100B SYP
2 hepatocyte apoptotic process GO:0097284 8.62 KRT18 KRT8

Molecular functions related to Papillary Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.92 GFAP KRT18 KRT8 NES

Sources for Papillary Ependymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....