MCID: PPL013
MIFTS: 33

Papillary Ependymoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Papillary Ependymoma

MalaCards integrated aliases for Papillary Ependymoma:

Name: Papillary Ependymoma 12 15 74
Ependymoma Papillary 56

Classifications:



External Ids:

Disease Ontology 12 DOID:5505
MeSH 45 D004806
NCIt 51 C4319
UMLS 74 C0334578

Summaries for Papillary Ependymoma

MalaCards based summary : Papillary Ependymoma, also known as ependymoma papillary, is related to ependymoma and benign ependymoma. An important gene associated with Papillary Ependymoma is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways are Neuroscience and Cytoskeleton remodeling Neurofilaments. The drugs Carboplatin and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and pineal.

Related Diseases for Papillary Ependymoma

Diseases related to Papillary Ependymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 238)
# Related Disease Score Top Affiliating Genes
1 ependymoma 31.9 ENO2 GFAP NES S100B SYP TTR
2 benign ependymoma 30.7 ENO2 GFAP RBFOX3 SYP
3 papilloma of choroid plexus 30.0 GFAP S100B SYP TTR
4 obstructive hydrocephalus 10.5 GFAP SYP
5 cerebellopontine angle tumor 10.5 GFAP SYP
6 pilomyxoid astrocytoma 10.5 GFAP SYP
7 syringoma 10.5 GFAP S100B
8 spindle cell rhabdomyosarcoma 10.5 GFAP S100B
9 chordoid glioma 10.5 GFAP S100B
10 ectopic cushing syndrome 10.5 S100B SYP
11 myxopapillary ependymoma 10.5 GFAP S100B
12 supratentorial primitive neuroectodermal tumor 10.4 S100B SYP
13 ileum cancer 10.4 ENO2 GFAP
14 rosette-forming glioneuronal tumor 10.4 S100B SYP
15 seminal vesicle tumor 10.4 KRT18 SYP
16 schneiderian carcinoma 10.4 KRT18 SYP
17 plexiform schwannoma 10.4 ENO2 GFAP
18 bone benign neoplasm 10.4 ENO2 SYP
19 connective tissue benign neoplasm 10.4 ENO2 SYP
20 microcystic meningioma 10.4 ENO2 GFAP
21 mixed cell type cancer 10.4 ENO2 SYP
22 dysgerminoma of ovary 10.4 ENO2 GFAP
23 glomus tumor 10.4 ENO2 SYP
24 mucinous ovarian cystadenoma 10.4 ENO2 SYP
25 juvenile pilocytic astrocytoma 10.4 ENO2 GFAP
26 rhabdoid cancer 10.4 ENO2 SYP
27 angiomyoma 10.4 ENO2 SYP
28 extraosseous chondrosarcoma 10.4 ENO2 SYP
29 intraocular retinoblastoma 10.4 ENO2 SYP
30 microglandular adenosis 10.4 KRT18 S100B
31 malignant teratoma 10.4 ENO2 SYP
32 spondylosis 10.4 ENO2 S100B
33 choroid plexus cancer 10.4 GFAP TTR
34 endometrial small cell carcinoma 10.4 ENO2 SYP
35 meningeal melanomatosis 10.4 ENO2 SYP
36 desmoplastic small round cell tumor 10.4 ENO2 SYP
37 extraskeletal ewing sarcoma 10.4 ENO2 SYP
38 brown-sequard syndrome 10.4 GFAP TTR
39 head injury 10.4 ENO2 S100B
40 retinal hemangioblastoma 10.4 ENO2 KRT18
41 desmoplastic infantile ganglioglioma 10.4 GFAP SYP
42 extraventricular neurocytoma 10.4 GFAP SYP
43 ganglioneuroblastoma 10.4 ENO2 SYP
44 purulent endophthalmitis 10.4 SAG SYP
45 dysentery 10.4 ENO2 TTR
46 lung combined type small cell carcinoma 10.4 GFAP SYP
47 carotid body cancer 10.4 ENO2 SYP
48 malignant sertoli cell tumor 10.3 ENO2 SYP
49 cancer-associated retinopathy 10.3 ENO2 SAG
50 gemistocytic astrocytoma 10.3 GFAP S100B

Graphical network of the top 20 diseases related to Papillary Ependymoma:



Diseases related to Papillary Ependymoma

Symptoms & Phenotypes for Papillary Ependymoma

Drugs & Therapeutics for Papillary Ependymoma

Drugs for Papillary Ependymoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3 41575-94-4 10339178 38904 498142
2
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
3
Etoposide Approved Phase 3 33419-42-0 36462
4
Cisplatin Approved Phase 3 15663-27-1 2767 441203 84093
5
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
6
Emodepside Investigational, Vet_approved Phase 3 155030-63-0
7 Antimitotic Agents Phase 3
8 Antineoplastic Agents, Alkylating Phase 3
9 Immunosuppressive Agents Phase 3
10 Keratolytic Agents Phase 3
11 Dermatologic Agents Phase 3
12 Podophyllotoxin Phase 3 518-28-5
13 Alkylating Agents Phase 3
14 Immunologic Factors Phase 3
15 Antirheumatic Agents Phase 3
16 Etoposide phosphate Phase 3
17 Antineoplastic Agents, Phytogenic Phase 3
18 Topoisomerase Inhibitors Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Maintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Ependymoma Recruiting NCT01096368 Phase 3 Carboplatin;Cisplatin;Cyclophosphamide;Etoposide;Vincristine Sulfate Liposome

Search NIH Clinical Center for Papillary Ependymoma

Genetic Tests for Papillary Ependymoma

Anatomical Context for Papillary Ependymoma

MalaCards organs/tissues related to Papillary Ependymoma:

42
Brain, Skin, Pineal, Spinal Cord, Ovary, Cervix, Bone

Publications for Papillary Ependymoma

Articles related to Papillary Ependymoma:

(show all 11)
# Title Authors Year
1
Papillary Ependymoma of the Spinal Cord: A Case Report with Summary of Prior Published Cases. ( 30937039 )
2019
2
Papillary ependymoma of the endometrium. ( 24845054 )
2014
3
Papillary ependymoma of the lateral ventricle: a rare low-grade variant of an uncommon neoplasm in the adult. ( 22295324 )
2011
4
Intramedullary papillary ependymoma with choroid plexus differentiation and cerebrospinal fluid dissemination to the brain. ( 20433266 )
2010
5
Papillary Ependymoma WHO Grade II of the Aqueduct Treated by Endoscopic Tumor Resection. ( 19724655 )
2009
6
Papillary ependymoma with unique superficial cortical location: immunohistochemical and ultrastructural studies. A case report. ( 20054788 )
2009
7
Equine papillary ependymoma. ( 8826009 )
1996
8
Papillary ependymoma: its differential diagnosis from choroid plexus papilloma. ( 8934397 )
1996
9
Myxo-papillary ependymoma: an unusual cause of a pelvic mass. ( 7926068 )
1994
10
Papillary ependymoma of the cervical spinal cord. ( 2927592 )
1989
11
Subcutaneous myxo-papillary ependymoma of the sacrococcygeal region. ( 5728921 )
1968

Variations for Papillary Ependymoma

Expression for Papillary Ependymoma

Search GEO for disease gene expression data for Papillary Ependymoma.

Pathways for Papillary Ependymoma

Pathways related to Papillary Ependymoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.63 ENO2 GFAP RBFOX3 S100B SAG SYP
2
Show member pathways
11.49 GFAP KRT18 KRT8 NES
3 11.15 GFAP NES S100B SYP

GO Terms for Papillary Ependymoma

Cellular components related to Papillary Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament cytoskeleton GO:0045111 9.13 GFAP KRT8 NES
2 intermediate filament GO:0005882 8.92 GFAP KRT18 KRT8 NES

Biological processes related to Papillary Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of neuronal synaptic plasticity GO:0048168 8.96 S100B SYP
2 hepatocyte apoptotic process GO:0097284 8.62 KRT18 KRT8

Molecular functions related to Papillary Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.8 GFAP KRT18 NES

Sources for Papillary Ependymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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