MCID: PPL017
MIFTS: 34

Papillary Hidradenoma

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Papillary Hidradenoma

MalaCards integrated aliases for Papillary Hidradenoma:

Name: Papillary Hidradenoma 12 15 73
Tubular Sweat Gland Adenomas 44

Classifications:



External Ids:

Disease Ontology 12 DOID:5439
MeSH 44 D000074009
NCIt 50 C4171
SNOMED-CT 68 89791006
UMLS 73 C0334348

Summaries for Papillary Hidradenoma

MalaCards based summary : Papillary Hidradenoma, also known as tubular sweat gland adenomas, is related to hidradenoma and adenocarcinoma. An important gene associated with Papillary Hidradenoma is ANXA11 (Annexin A11), and among its related pathways/superpathways are Tyrosine Kinases / Adaptors and Signaling by ERBB4. Affiliated tissues include skin, lung and ovary, and related phenotypes are cardiovascular system and endocrine/exocrine gland

Wikipedia : 76 A papillary hidradenoma, also hidradenoma papilliferum, is a sharply circumscribed nodule or benign... more...

Related Diseases for Papillary Hidradenoma

Diseases related to Papillary Hidradenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 hidradenoma 31.1 ANXA11 PIK3CA
2 adenocarcinoma 30.0 ERBB4 KIT PIK3CA STK11
3 syringocystadenoma papilliferum 11.2
4 cervical adenoma malignum 10.2 MME STK11
5 cervical mucinous adenocarcinoma 10.2 MME STK11
6 myxoid leiomyosarcoma 10.2 MME PGR
7 uterine body mixed cancer 10.2 PGR PIK3CA
8 cribriform carcinoma 10.2 KIT PGR
9 adenoid basal cell carcinoma 10.2 KIT PGR
10 endometrial squamous cell carcinoma 10.2 AR PGR
11 apocrine adenocarcinoma 10.2 AR PGR
12 cervical carcinosarcoma 10.2 MME PGR
13 aggressive digital papillary adenocarcinoma 10.2 KIT PIK3CA
14 gender identity disorder 10.2 AR PGR
15 corneal abscess 10.2 AR PGR
16 malignant leydig cell tumor 10.2 KIT MME
17 lung adenoid cystic carcinoma 10.2 KIT PIK3CA
18 warthin tumor 10.2 ERBB4 KIT
19 fox-fordyce disease 10.2 KIT PIP
20 ceruminoma 10.2 KIT PIP
21 rete testis adenocarcinoma 10.2 KIT MME
22 endometrial stromal nodule 10.2 MME PGR
23 bartholin's duct cyst 10.2 AR PIP
24 microglandular adenosis 10.2 PGR PIP
25 gastric signet ring cell adenocarcinoma 10.1 PGR PIP
26 mast-cell leukemia 10.1 KIT PIK3CA
27 acneiform dermatitis 10.1 ERBB4 PIK3CA
28 breast adenomyoepithelioma 10.1 MME PIK3CA
29 spermatocele 10.1 MME PGR
30 breast myoepithelial neoplasm 10.1 MME PIK3CA
31 deep angioma 10.1 ANXA2 PGR
32 benign breast phyllodes tumor 10.1 KIT MME PGR
33 leiomyoma 10.1 KIT MME PGR
34 cystic nephroma 10.1 KIT MME PGR
35 perivascular epithelioid cell tumor 10.1 KIT MME PGR
36 intramuscular hemangioma 10.1 ANXA2 PGR
37 adenosarcoma 10.1 KIT MME PGR
38 mixed cell type cancer 10.1 KIT MME PGR
39 breast adenoid cystic carcinoma 10.1 AR KIT PGR
40 peritoneal benign neoplasm 10.1 AR KIT PGR
41 endometrial stromal sarcoma 10.1 KIT MME PGR
42 diffuse peritoneal leiomyomatosis 10.1 AR KIT PGR
43 dermoid cyst 10.1 KIT PGR
44 renal cell carcinoma, papillary, 1 10.1 KIT MME PIK3CA
45 breast benign neoplasm 10.1 MME PGR PIP
46 thoracic benign neoplasm 10.1 MME PGR PIP
47 rete testis neoplasm 10.1 KIT MME
48 cutaneous ganglioneuroma 10.1 KIT S100A6
49 paget disease, extramammary 10.1 AR ERBB4 PIP
50 oncocytic breast carcinoma 10.1 AR PGR PIP

Graphical network of the top 20 diseases related to Papillary Hidradenoma:



Diseases related to Papillary Hidradenoma

Symptoms & Phenotypes for Papillary Hidradenoma

MGI Mouse Phenotypes related to Papillary Hidradenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.06 ANXA2 ANXA6 AR ERBB4 KIT PGR
2 endocrine/exocrine gland MP:0005379 9.97 AR ERBB4 KIT PGR PIK3CA PIP
3 hematopoietic system MP:0005397 9.97 ANXA2 ANXA6 AR CTNNBL1 ERBB4 KIT
4 immune system MP:0005387 9.96 ANXA6 AR CTNNBL1 ERBB4 KIT MME
5 integument MP:0010771 9.76 ANXA6 AR ERBB4 KIT MME PGR
6 muscle MP:0005369 9.5 ANXA6 AR ERBB4 KIT PGR PIK3CA
7 reproductive system MP:0005389 9.23 AR ERBB4 KIT PGR PIK3CA PIP

Drugs & Therapeutics for Papillary Hidradenoma

Search Clinical Trials , NIH Clinical Center for Papillary Hidradenoma

Cochrane evidence based reviews: tubular sweat gland adenomas

Genetic Tests for Papillary Hidradenoma

Anatomical Context for Papillary Hidradenoma

MalaCards organs/tissues related to Papillary Hidradenoma:

41
Skin, Lung, Ovary, Prostate, Testis, Smooth Muscle

Publications for Papillary Hidradenoma

Articles related to Papillary Hidradenoma:

# Title Authors Year
1
Mutations in genes encoding PI3K-AKT and MAPK signaling define anogenital papillary hidradenoma. ( 26493284 )
2015
2
Papillary hidradenoma of the eyelid margin: clinical and immunohistochemical observations further supporting an apocrine rather than an eccrine origin. ( 24661803 )
2014
3
Adenocarcinoma in situ arising in vulvar papillary hidradenoma: report of 2 cases. ( 18580327 )
2008
4
Papillary hidradenoma: immunohistochemical analysis of steroid receptor profile with a focus on apocrine differentiation. ( 10690173 )
1999
5
Fine-needle aspiration diagnosis of a vulvar papillary hidradenoma: a case report. ( 8005045 )
1994
6
Cystic papillary hidradenoma of the vulva: case report and review of the literature. ( 3026933 )
1987
7
Identification of papillary hidradenoma of the vulva by imprint cytology. ( 6254297 )
1980
8
Diagnosis of a papillary hidradenoma of the vulva by simultaneous cytology and colposcopy. ( 219648 )
1979
9
Papillary hidradenoma of the vulva: a clinicopathologic study of 69 cases. ( 4325819 )
1971

Variations for Papillary Hidradenoma

Expression for Papillary Hidradenoma

Search GEO for disease gene expression data for Papillary Hidradenoma.

Pathways for Papillary Hidradenoma

Pathways related to Papillary Hidradenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.6 ANXA2 ERBB4 KIT
2
Show member pathways
11.17 ERBB4 PGR PIK3CA
3 10.41 AR PIK3CA
4 10.28 ANXA2 ANXA6 S100A6

GO Terms for Papillary Hidradenoma

Cellular components related to Papillary Hidradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.56 ANXA11 ANXA2 ANXA6 GAPDH MME PIP
2 vesicle GO:0031982 9.5 ANXA2 GAPDH WDFY2
3 cytoplasm GO:0005737 9.47 ANXA11 ANXA2 ANXA6 AR CTNNBL1 ERBB4
4 collagen-containing extracellular matrix GO:0062023 9.46 ANXA11 ANXA2 ANXA6 S100A6
5 melanosome GO:0042470 9.43 ANXA11 ANXA2 ANXA6

Biological processes related to Papillary Hidradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein autophosphorylation GO:0046777 9.65 ERBB4 KIT STK11
2 positive regulation of protein kinase B signaling GO:0051897 9.63 ERBB4 KIT PIK3CA
3 positive regulation of MAPK cascade GO:0043410 9.54 AR ERBB4 KIT
4 positive regulation of JAK-STAT cascade GO:0046427 9.43 ERBB4 KIT
5 phosphatidylinositol phosphorylation GO:0046854 9.43 ERBB4 KIT PIK3CA
6 vasculature development GO:0001944 9.4 PIK3CA STK11
7 mammary gland alveolus development GO:0060749 9.32 AR ERBB4
8 anoikis GO:0043276 9.16 PIK3CA STK11
9 cellular response to UV-B GO:0071493 8.96 MME STK11
10 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 8.62 AR PGR

Molecular functions related to Papillary Hidradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.67 ANXA6 AR CTNNBL1 PGR
2 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.5 ERBB4 KIT PIK3CA
3 calcium-dependent phospholipid binding GO:0005544 9.43 ANXA11 ANXA2 ANXA6
4 protein kinase activator activity GO:0030295 9.4 PIK3CA STK11
5 S100 protein binding GO:0044548 9.13 ANXA11 ANXA2 S100A6
6 calcium-dependent protein binding GO:0048306 8.92 ANXA11 ANXA2 ANXA6 S100A6
7 protein binding GO:0005515 10.03 ANXA11 ANXA2 ANXA6 AR CTNNBL1 ERBB4

Sources for Papillary Hidradenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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