MCID: PPL017
MIFTS: 36

Papillary Hidradenoma

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Papillary Hidradenoma

MalaCards integrated aliases for Papillary Hidradenoma:

Name: Papillary Hidradenoma 12 15 74
Tubular Sweat Gland Adenomas 45

Classifications:



External Ids:

Disease Ontology 12 DOID:5439
MeSH 45 D000074009
NCIt 51 C4171
SNOMED-CT 69 89791006
UMLS 74 C0334348

Summaries for Papillary Hidradenoma

MalaCards based summary : Papillary Hidradenoma, also known as tubular sweat gland adenomas, is related to adenocarcinoma and syringocystadenoma papilliferum. An important gene associated with Papillary Hidradenoma is ANXA11 (Annexin A11), and among its related pathways/superpathways are ERK Signaling and Akt Signaling. Affiliated tissues include skin, ovary and testis, and related phenotypes are cardiovascular system and muscle

Wikipedia : 77 A papillary hidradenoma, also hidradenoma papilliferum, is a sharply circumscribed nodule or benign... more...

Related Diseases for Papillary Hidradenoma

Diseases related to Papillary Hidradenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 29.9 ERBB4 KIT PIK3CA STK11
2 syringocystadenoma papilliferum 11.3
3 hidradenoma 10.5
4 calcifying aponeurotic fibroma 10.4 ACTC1 PGR
5 bizarre leiomyoma 10.4 ACTC1 PGR
6 baraitser-winter cerebrofrontofacial syndrome 10.4 ACTB ACTG1
7 benign metastasizing leiomyoma 10.4 ACTC1 PGR
8 ovarian fibrothecoma 10.3 ACTC1 KIT
9 cervical adenoma malignum 10.3 MME STK11
10 shrimp allergy 10.3 ACTB GAPDH
11 cervical mucinous adenocarcinoma 10.3 MME STK11
12 adenofibroma 10.3 ACTC1 MME
13 cribriform carcinoma 10.2 KIT PGR
14 adenoid basal cell carcinoma 10.2 KIT PGR
15 oncocytic breast carcinoma 10.2 PGR PIP
16 peritoneal benign neoplasm 10.2 KIT PGR
17 myxoid leiomyosarcoma 10.2 ACTC1 MME PGR
18 uterine body mixed cancer 10.2 PGR PIK3CA
19 aggressive digital papillary adenocarcinoma 10.2 KIT PIK3CA
20 diffuse peritoneal leiomyomatosis 10.2 KIT PGR
21 leiomyosarcoma 10.2 ACTC1 KIT PGR
22 fox-fordyce disease 10.2 KIT PIP
23 ceruminoma 10.2 KIT PIP
24 juvenile nasopharyngeal angiofibroma 10.2 ACTC1 KIT PGR
25 malignant leydig cell tumor 10.2 KIT MME
26 angiomyolipoma 10.2 ACTC1 KIT PGR
27 breast adenoid cystic carcinoma 10.1 KIT PGR
28 deep angioma 10.1 ANXA2 PGR
29 pulmonary vein stenosis 10.1 ACTC1 KIT
30 lung adenoid cystic carcinoma 10.1 KIT PIK3CA
31 benign breast phyllodes tumor 10.1 KIT MME PGR
32 crustacean allergy 10.1 ACTB GAPDH
33 bartholin's gland disease 10.1 PGR PIP
34 cystic nephroma 10.1 KIT MME PGR
35 adenosarcoma 10.1 KIT MME PGR
36 mixed cell type cancer 10.1 KIT MME PGR
37 cutaneous ganglioneuroma 10.1 KIT S100A6
38 breast benign neoplasm 10.1 MME PGR PIP
39 thoracic benign neoplasm 10.1 MME PGR PIP
40 renal cell carcinoma, papillary, 1 10.0 KIT MME PIK3CA
41 adenocarcinoma in situ 10.0
42 dysgerminoma of ovary 10.0 ANXA2 KIT PGR
43 perivascular epithelioid cell tumor 10.0 ACTC1 KIT MME PGR
44 smooth muscle tumor 10.0 ACTC1 KIT MME PGR
45 uterine corpus cancer 10.0 PGR PIK3CA S100A6
46 endometrial stromal sarcoma 10.0 ACTC1 KIT MME PGR
47 leiomyoma 10.0 ACTC1 KIT MME PGR
48 adenoid cystic carcinoma 10.0 ACTC1 KIT PGR PIK3CA
49 rete testis adenocarcinoma 9.9 KIT MME
50 cervical carcinosarcoma 9.9 MME PGR

Graphical network of the top 20 diseases related to Papillary Hidradenoma:



Diseases related to Papillary Hidradenoma

Symptoms & Phenotypes for Papillary Hidradenoma

MGI Mouse Phenotypes related to Papillary Hidradenoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.9 ACTA2 ACTB ACTC1 ANXA2 ANXA6 ERBB4
2 muscle MP:0005369 9.7 ACTA1 ACTA2 ACTB ACTC1 ACTG1 ANXA6
3 reproductive system MP:0005389 9.28 ACTA1 ACTB ERBB4 KIT PGR PIK3CA

Drugs & Therapeutics for Papillary Hidradenoma

Search Clinical Trials , NIH Clinical Center for Papillary Hidradenoma

Cochrane evidence based reviews: tubular sweat gland adenomas

Genetic Tests for Papillary Hidradenoma

Anatomical Context for Papillary Hidradenoma

MalaCards organs/tissues related to Papillary Hidradenoma:

42
Skin, Ovary, Testis, Smooth Muscle

Publications for Papillary Hidradenoma

Articles related to Papillary Hidradenoma:

# Title Authors Year
1
Mutations in genes encoding PI3K-AKT and MAPK signaling define anogenital papillary hidradenoma. ( 26493284 )
2016
2
Papillary hidradenoma of the eyelid margin: clinical and immunohistochemical observations further supporting an apocrine rather than an eccrine origin. ( 24661803 )
2014
3
Adenocarcinoma in situ arising in vulvar papillary hidradenoma: report of 2 cases. ( 18580327 )
2008
4
Papillary hidradenoma: immunohistochemical analysis of steroid receptor profile with a focus on apocrine differentiation. ( 10690173 )
1999
5
Fine-needle aspiration diagnosis of a vulvar papillary hidradenoma: a case report. ( 8005045 )
1994
6
Cystic papillary hidradenoma of the vulva: case report and review of the literature. ( 3026933 )
1987
7
Identification of papillary hidradenoma of the vulva by imprint cytology. ( 6254297 )
1980
8
Diagnosis of a papillary hidradenoma of the vulva by simultaneous cytology and colposcopy. ( 219648 )
1979
9
Papillary hidradenoma of the vulva: a clinicopathologic study of 69 cases. ( 4325819 )
1971

Variations for Papillary Hidradenoma

Expression for Papillary Hidradenoma

Search GEO for disease gene expression data for Papillary Hidradenoma.

Pathways for Papillary Hidradenoma

Pathways related to Papillary Hidradenoma according to GeneCards Suite gene sharing:

(show all 46)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.82 ACTA1 ACTA2 ACTB ACTG1 ACTG2 ERBB4
2
Show member pathways
13.4 ACTA1 ACTA2 ACTB ACTG1 ACTG2 ERBB4
3
Show member pathways
13.27 ACTA1 ACTA2 ACTB ACTG1 ACTG2 KIT
4
Show member pathways
13.25 ACTA1 ACTA2 ACTB ACTG1 ACTG2 ERBB4
5
Show member pathways
13.04 ACTA1 ACTA2 ACTB ACTG1 ACTG2 KIT
6
Show member pathways
13.03 ACTA1 ACTA2 ACTB ACTG1 ACTG2 STK11
7
Show member pathways
12.98 ACTA1 ACTA2 ACTB ACTG1 ACTG2 GAPDH
8
Show member pathways
12.94 ACTA1 ACTA2 ACTB ACTG1 ACTG2 PIK3CA
9
Show member pathways
12.91 ACTA1 ACTA2 ACTB ACTC1 ACTG1 ACTG2
10
Show member pathways
12.87 ACTA1 ACTA2 ACTB ACTG1 ACTG2
11
Show member pathways
12.87 ACTA1 ACTA2 ACTB ACTG1 ACTG2
12
Show member pathways
12.87 ACTA1 ACTA2 ACTB ACTG1 ACTG2 ERBB4
13
Show member pathways
12.74 ACTB ACTG1 KIT PGR PIK3CA
14
Show member pathways
12.65 ACTA1 ACTA2 ACTB ACTC1 ACTG1 ACTG2
15
Show member pathways
12.64 ACTA1 ACTA2 ACTB ACTG1 ACTG2
16
Show member pathways
12.55 ACTA1 ACTA2 ACTB ACTC1 ACTG1 ACTG2
17
Show member pathways
12.54 ACTA1 ACTA2 ACTB ACTC1 ACTG1 ANXA6
18 12.51 ACTA1 ACTA2 ACTB ACTC1 ACTG1 ACTG2
19
Show member pathways
12.44 ACTA1 ACTA2 ACTB ACTG1 ACTG2
20
Show member pathways
12.41 ACTA1 ACTA2 ACTB ACTG1 ACTG2
21
Show member pathways
12.4 ACTA1 ACTA2 ACTB ACTG1 ACTG2
22
Show member pathways
12.39 ACTA1 ACTA2 ACTB ACTG1 ACTG2 PIK3CA
23
Show member pathways
12.3 ACTA1 ACTA2 ACTB ACTG1 ACTG2 ERBB4
24 12.27 ACTB ACTG1 ERBB4 PIK3CA
25
Show member pathways
12.22 ACTA1 ACTA2 ACTB ACTG1 ACTG2 PIK3CA
26 12.09 ACTA1 ACTA2 ACTB ACTG1 ACTG2
27 12 ACTA1 ACTA2 ACTB ACTG1 ACTG2
28 11.96 ACTB ACTG1 PIK3CA
29 11.96 ACTA1 ACTA2 ACTB ACTG1 ACTG2
30
Show member pathways
11.95 ACTA1 ACTA2 ACTB ACTG1 ACTG2
31 11.93 ACTB ACTG1 PIK3CA
32
Show member pathways
11.9 ERBB4 PGR PIK3CA
33 11.77 ACTA1 ACTA2 ACTC1 ACTG1
34 11.73 ACTB ACTG1 PIK3CA
35 11.73 ACTA1 ACTA2 ACTB ACTG1 ACTG2
36 11.65 ACTA1 ACTA2 ACTB ACTG1 ACTG2
37 11.45 ACTA1 ACTA2 ACTB ACTC1 ACTG1 ACTG2
38 11.4 ACTA1 ACTA2 ACTB ACTG1 ACTG2
39 11.39 ACTA1 ACTA2 ACTB ACTG1 ACTG2 ERBB4
40 11.31 ACTA2 ACTG2 ANXA2 ANXA6
41 11.3 ACTA1 ACTA2 ACTB ACTG1 ACTG2
42 11.29 ANXA2 ANXA6 S100A6
43 11.29 ACTA1 ACTA2 ACTB ACTG1 ACTG2 ERBB4
44 11.09 ACTA1 ACTA2 ACTB ACTG1 ACTG2
45 10.7 ACTA1 ACTA2 ACTB ACTC1 ACTG1 ACTG2
46 10.63 ACTA1 ACTA2 ACTB ACTG1 ACTG2

GO Terms for Papillary Hidradenoma

Cellular components related to Papillary Hidradenoma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 focal adhesion GO:0005925 9.91 ACTB ACTC1 ACTG1 ANXA6 MME
2 cytoplasm GO:0005737 9.89 ACTA1 ACTA2 ACTB ACTC1 ACTG1 ACTG2
3 collagen-containing extracellular matrix GO:0062023 9.85 ANXA11 ANXA2 ANXA6 S100A6
4 actin cytoskeleton GO:0015629 9.83 ACTA1 ACTA2 ACTB ACTG1
5 vesicle GO:0031982 9.78 ACTB ANXA2 GAPDH WDFY2
6 melanosome GO:0042470 9.73 ANXA11 ANXA2 ANXA6
7 actin filament GO:0005884 9.71 ACTA1 ACTC1 ACTG1
8 cell body GO:0044297 9.67 ACTA1 ACTA2 ACTC1 ACTG2
9 lamellipodium GO:0030027 9.65 ACTA1 ACTA2 ACTC1 ACTG2 PIK3CA
10 filopodium GO:0030175 9.62 ACTA1 ACTA2 ACTC1 ACTG2
11 blood microparticle GO:0072562 9.55 ACTA1 ACTB ACTC1 ACTG1 ACTG2
12 dense body GO:0097433 9.49 ACTB ACTG1
13 extracellular exosome GO:0070062 9.47 ACTA1 ACTA2 ACTB ACTC1 ACTG1 ACTG2
14 cytosol GO:0005829 10.25 ACTA1 ACTA2 ACTB ACTC1 ACTG1 ACTG2
15 extracellular space GO:0005615 10.11 ACTA1 ACTA2 ACTB ACTC1 ACTG1 ACTG2
16 cytoskeleton GO:0005856 10.03 ACTA1 ACTA2 ACTB ACTC1 ACTG1 ACTG2

Biological processes related to Papillary Hidradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle contraction GO:0006936 9.61 ACTA1 ACTA2 ACTG2
2 cell junction assembly GO:0034329 9.46 ACTB ACTG1
3 positive regulation of gene expression GO:0010628 9.43 ACTA1 ACTA2 ACTC1 ACTG2 KIT PIP
4 skeletal muscle thin filament assembly GO:0030240 9.37 ACTA1 ACTC1
5 retina homeostasis GO:0001895 9.33 ACTB ACTG1 PIP
6 anoikis GO:0043276 9.32 STK11 PIK3CA
7 cellular response to UV-B GO:0071493 9.26 STK11 MME
8 phosphatidylinositol phosphorylation GO:0046854 9.1 PIK3CA
9 mesenchyme migration GO:0090131 8.92 ACTA1 ACTA2 ACTC1 ACTG2

Molecular functions related to Papillary Hidradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.58 ACTA1 ACTB ACTG1
2 calcium-dependent phospholipid binding GO:0005544 9.43 ANXA11 ANXA2 ANXA6
3 S100 protein binding GO:0044548 9.33 ANXA11 ANXA2 S100A6
4 ATP binding GO:0005524 9.32 ACTA1 ACTA2 ACTB ACTC1 ACTG1 ACTG2
5 calcium-dependent protein binding GO:0048306 9.26 ANXA11 ANXA2 ANXA6 S100A6
6 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.02 PIK3CA
7 protein binding GO:0005515 10.27 ACTA1 ACTB ACTG1 ANXA11 ANXA2 ANXA6

Sources for Papillary Hidradenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....