Papillary Squamous Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Papillary Squamous Carcinoma

MalaCards integrated aliases for Papillary Squamous Carcinoma:

Name: Papillary Squamous Carcinoma ¹¹ ¹⁴

Papillary Squamous Cell Carcinoma ⁷¹

Papillary Epidermoid Carcinoma ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:4385

NCIt ⁴⁹ C4102

SNOMED-CT ⁶⁸ 39056008

UMLS ⁷¹ C0334244

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Summaries for Papillary Squamous Carcinoma

Disease Ontology: ¹¹ A squamous cell carcinoma that has papillae, which are characterized either by narrow fibrovascular cores that superficially resemble papillary carcinoma of the urinary tract or by broad cores that contain edematous fibrous stroma with prominent capillaries and stromal inflammation.

MalaCards based summary: Papillary Squamous Carcinoma, also known as papillary squamous cell carcinoma, is related to hemometra and isthmus cancer. An important gene associated with Papillary Squamous Carcinoma is MAPK8IP1 (Mitogen-Activated Protein Kinase 8 Interacting Protein 1), and among its related pathways/superpathways are Validated transcriptional targets of deltaNp63 isoforms and Bladder cancer. The drugs Cisplatin and Nivolumab have been mentioned in the context of this disorder. Affiliated tissues include cervix, and related phenotype is Increased shRNA abundance (Z-score > 2).

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Related Diseases for Papillary Squamous Carcinoma

Diseases related to Papillary Squamous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 332)

#	Related Disease	Score	Top Affiliating Genes
1	hemometra	10.2	MAPK8IP1 INSM1
2	isthmus cancer	10.2	MAPK8IP1 INSM1
3	lymphocele	10.2	MAPK8IP1 INSM1
4	cervical incompetence	10.2	MAPK8IP1 INSM1
5	cervix small cell carcinoma	10.2	SYP MAPK8IP1
6	cervix erosion	10.2	MAPK8IP1 KRT5
7	anal canal squamous cell carcinoma	10.2	MAPK8IP1 KRT5
8	endometrial small cell carcinoma	10.2	SYP MAPK8IP1
9	pulmonary large cell neuroendocrine carcinoma	10.2	SYP INSM1
10	pulmonary neuroendocrine tumor	10.2	SYP INSM1
11	thymus basaloid carcinoma	10.2	SYP KRT5
12	cloacogenic carcinoma	10.2	SYP KRT5
13	squamous cell carcinoma	10.2
14	early invasive cervical adenocarcinoma	10.2	INSM1 CDKN2A
15	cervix endometriosis	10.2	MAPK8IP1 CDKN2A
16	tracheal cancer	10.2	SYP KRT5
17	cervical adenosquamous carcinoma	10.1	MAPK8IP1 CDKN2A
18	prostate signet ring cell adenocarcinoma	10.1	SYP KRT5
19	vulvar eccrine porocarcinoma	10.1	SYP CDKN2A
20	frontal lobe neoplasm	10.1	SYP EGFR
21	esophageal neuroendocrine tumor	10.1	SYP KRT5
22	fallopian tube endometrioid adenocarcinoma	10.1	INSM1 CDKN2A
23	chronic cervicitis	10.1	INSM1 CDKN2A
24	penile urethral cancer	10.1	KRT5 CDKN2A
25	spinal cord oligodendroglioma	10.1	SYP EGFR
26	gallbladder small cell carcinoma	10.1	SYP CDKN2A
27	pancreatoblastoma	10.1	SYP CDKN2A
28	cutaneous ganglioneuroma	10.1	SYP EGFR
29	lymphohistiocytoid mesothelioma	10.1	KRT5 CDKN2A
30	tonsillar pillar cancer	10.1	EGFR CDKN2A
31	breast malignant phyllodes tumor	10.1	KRT5 EGFR
32	pleomorphic xanthoastrocytoma	10.1	SYP CDKN2A
33	sarcomatoid mesothelioma	10.1	KRT5 CDKN2A
34	esophagus verrucous carcinoma	10.1	EGFR CDKN2A
35	acanthoma	10.1	KRT5 CDKN2A
36	synchronous bilateral breast carcinoma	10.1	KRT5 EGFR
37	cellular ependymoma	10.1	SYP EGFR
38	lobular neoplasia	10.0	KRT5 EGFR
39	hypertrophy of breast	10.0	KRT5 EGFR
40	pancreatic cystadenoma	10.0	SYP INSM1
41	idh-wildtype glioblastoma	10.0	EGFR CDKN2A
42	bone squamous cell carcinoma	10.0	EGFR CDKN2A
43	adult malignant schwannoma	10.0	EGFR CDKN2A
44	mixed glioma	10.0	EGFR CDKN2A
45	supratentorial cancer	10.0	SYP CDKN2A
46	inverted papilloma	10.0	KRT5 CDKN2A
47	vulva squamous cell carcinoma	10.0	EGFR CDKN2A
48	laryngeal benign neoplasm	10.0	EGFR CDKN2A
49	pulmonary blastoma	10.0	SYP EGFR
50	hypopharynx cancer	10.0	EGFR CDKN2A

Graphical network of the top 20 diseases related to Papillary Squamous Carcinoma:

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Symptoms & Phenotypes for Papillary Squamous Carcinoma

GenomeRNAi Phenotypes related to Papillary Squamous Carcinoma according to GeneCards Suite gene sharing:

²⁵ (show all 22)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-100	9.7	INSM1
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-121	9.7	EGFR
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-13	9.7	KRT5
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-135	9.7	KRT7
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-143	9.7	KRT5
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-149	9.7	INSM1
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-162	9.7	INSM1
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-17	9.7	KRT5
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-180	9.7	KRT5
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-192	9.7	KRT7
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-200	9.7	KRT5
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-21	9.7	EGFR
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-214	9.7	EGFR
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-43	9.7	EGFR
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-53	9.7	INSM1
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-57	9.7	INSM1
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-68	9.7	KRT7
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-72	9.7	KRT7
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-74	9.7	KRT7
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	9.7	EGFR
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-91	9.7	EGFR KRT5 KRT7
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-93	9.7	INSM1

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Drugs & Therapeutics for Papillary Squamous Carcinoma

Drugs for Papillary Squamous Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Cisplatin

Approved

Phase 2, Phase 3

15663-27-1

2767 5702198 441203

2

Nivolumab

Approved

Phase 2, Phase 3

946414-94-4

3

Immune Checkpoint Inhibitors

Phase 2, Phase 3

4

Antineoplastic Agents, Immunological

Phase 2, Phase 3

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Randomized Phase II/III Trial of De-Intensified Radiation Therapy for Patients With Early-Stage, P16-Positive, Non-Smoking Associated Oropharyngeal Cancer	Recruiting	NCT03952585	Phase 2, Phase 3	Cisplatin

Search NIH Clinical Center for Papillary Squamous Carcinoma

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Genetic Tests for Papillary Squamous Carcinoma

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Anatomical Context for Papillary Squamous Carcinoma

Organs/tissues related to Papillary Squamous Carcinoma:

MalaCards : Cervix

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Publications for Papillary Squamous Carcinoma

Articles related to Papillary Squamous Carcinoma:

#	Title	Authors	PMID	Year
1	Histopathologic risk factors in oral and oropharyngeal squamous cell carcinoma variants: an update with special reference to HPV-related carcinomas. ⁶²	El-Mofty SK	24880454	2014
2	HPV-related squamous cell carcinoma variants in the head and neck. ⁶²	El-Mofty SK	22782224	2012
3	De novo papillary squamous carcinoma of the lacrimal sac. ⁶²	Salib RJ...Afoakwah EO	12753996	2003
4	Papillary squamous carcinoma: will the real one please stand up? ⁶²	Batsakis JG...Suarez P	10640196	2000
5	Papillary immature metaplasia (immature condyloma) of the cervix: a clinicopathologic analysis and comparison with papillary squamous carcinoma. ⁶²	Trivijitsilp P...Crum CP	9635687	1998
6	Results of the radiotherapeutic management of carcinoma of the cervix with emphasis on the influence of histologic classification. ⁶²	Randall ME...Mills SE	3133103	1988
7	Inverting papilloma of the nose: analysis of 48 patients. ⁶²	Smith O...Gullane PJ	3599169	1987

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Genes for Papillary Squamous Carcinoma

Genes related to Papillary Squamous Carcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MAPK8IP1	Mitogen-Activated Protein Kinase 8 Interacting Protein 1	Protein Coding	5.64	DISEASES inferred ¹⁴
2	INSM1	INSM Transcriptional Repressor 1	Protein Coding	5.46	DISEASES inferred ¹⁴
3	SYP	Synaptophysin	Protein Coding	3.84	DISEASES inferred ¹⁴
4	KRT5	Keratin 5	Protein Coding	3.3	DISEASES inferred ¹⁴
5	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	3.3	DISEASES inferred ¹⁴
6	ELN	Elastin	Protein Coding	3.08	DISEASES inferred ¹⁴
7	KRT7	Keratin 7	Protein Coding	3.05	DISEASES inferred ¹⁴
8	EGFR	Epidermal Growth Factor Receptor	Protein Coding	2.83	DISEASES inferred ¹⁴

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Variations for Papillary Squamous Carcinoma

Cosmic variations for Papillary Squamous Carcinoma:

⁸ (show top 50) (show all 5642)

#	Cosmic Mut ID	Gene Symbol	COSMIC Disease Classification (Primary site, Site subtype, Primary histology, Histology subtype)	Mutation CDS	Mutation AA	GRCh38 Location	Conf
1	COSM107899595	TP63	urinary tract,NS,carcinoma,squamous cell carcinoma	c.562A>C	p.K188Q	3:189808509-189808509	7
2	COSM89456209	TP63	urinary tract,NS,carcinoma,squamous cell carcinoma	c.280A>C	p.K94Q	3:189808509-189808509	7
3	COSM90483663	TP63	urinary tract,NS,carcinoma,squamous cell carcinoma	c.562A>C	p.K188Q	3:189808509-189808509	7
4	COSM113477332	TP63	urinary tract,NS,carcinoma,squamous cell carcinoma	c.42+18667A>C	p.?	3:189808509-189808509	7
5	COSM88650776	TP63	urinary tract,NS,carcinoma,squamous cell carcinoma	c.562A>C	p.K188Q	3:189808509-189808509	7
6	COSM98198072	TP63	urinary tract,NS,carcinoma,squamous cell carcinoma	c.280A>C	p.K94Q	3:189808509-189808509	7
7	COSM104666843	TP63	urinary tract,NS,carcinoma,squamous cell carcinoma	c.562A>C	p.K188Q	3:189808509-189808509	7
8	COSM109398849	TP63	urinary tract,NS,carcinoma,squamous cell carcinoma	c.280A>C	p.K94Q	3:189808509-189808509	7
9	COSM98159381	TP63	urinary tract,NS,carcinoma,squamous cell carcinoma	c.562A>C	p.K188Q	3:189808509-189808509	7
10	COSM98183008	TP63	urinary tract,NS,carcinoma,squamous cell carcinoma	c.280A>C	p.K94Q	3:189808509-189808509	7
11	COSM114687375	TP63	urinary tract,NS,carcinoma,squamous cell carcinoma	c.280A>C	p.K94Q	3:189808509-189808509	7
12	COSM122751334	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.308A>G	p.N103S	17:7674259-7674259	7
13	COSM93190467	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.874A>G	p.K292E	17:7673746-7673746	7
14	COSM106053212	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.795G>C	p.L265=	17:7673825-7673825	7
15	COSM144670184	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.694G>A	p.E232K	17:7673809-7673809	7
16	COSM122271260	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.422G>A	p.R141H	17:7673802-7673802	7
17	COSM143373275	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.722G>A	p.R241K	17:7673781-7673781	7
18	COSM87898458	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.853G>A	p.E285K	17:7673767-7673767	7
19	COSM143156898	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.376G>A	p.E126K	17:7673767-7673767	7
20	COSM144325168	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.587A>G	p.N196S	17:7674259-7674259	7
21	COSM121875871	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.461A>G	p.E154G	17:7673763-7673763	7
22	COSM111771867	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.396G>C	p.K132N	17:7675216-7675216	7
23	COSM93184755	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.586C>T	p.R196*	17:7674945-7674945	7
24	COSM106055208	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.637C>T	p.R213*	17:7674894-7674894	7
25	COSM105619860	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.524G>A	p.R175H	17:7675088-7675088	7
26	COSM144028995	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.778G>A	p.E260K	17:7673809-7673809	7
27	COSM144013089	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.785G>A	p.R262H	17:7673802-7673802	7
28	COSM143944174	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.298G>A	p.D100N	17:7674188-7674188	7
29	COSM111776584	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.811G>A	p.E271K	17:7673809-7673809	7
30	COSM144096591	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.-82G>C	p.?	17:7675216-7675216	7
31	COSM142755507	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.688A>T	p.S230C	17:7673815-7673815	7
32	COSM144013682	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.811C>T	p.R271W	17:7673776-7673776	7
33	COSM143943546	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.341G>A	p.R114H	17:7673802-7673802	7
34	COSM143156608	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.47G>A	p.R16H	17:7675088-7675088	7
35	COSM121889671	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.-1G>C	p.?	17:7675216-7675216	7
36	COSM144088618	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.160C>T	p.R54*	17:7674894-7674894	7
37	COSM142571831	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.279G>C	p.K93N	17:7675216-7675216	7
38	COSM105627556	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.782+435A>G	p.?	17:7673746-7673746	7
39	COSM143164052	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.-3G>T	p.?	17:7675137-7675137	7
40	COSM143370575	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.701G>A	p.R234H	17:7673802-7673802	7
41	COSM111758217	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.818G>A	p.R273H	17:7673802-7673802	7
42	COSM106069985	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.811G>A	p.E271K	17:7673809-7673809	7
43	COSM144670704	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.592A>G	p.M198V	17:7674254-7674254	7
44	COSM144650760	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.701G>A	p.R234H	17:7673802-7673802	7
45	COSM105639894	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.704A>G	p.N235S	17:7674259-7674259	7
46	COSM143943820	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.336G>A	p.E112=	17:7673807-7673807	7
47	COSM112255322	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.637C>T	p.R213*	17:7674894-7674894	7
48	COSM121876050	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.326C>T	p.S109F	17:7674241-7674241	7
49	COSM142837327	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.560G>A	p.G187D	17:7674971-7674971	7
50	COSM144093356	TP53	urinary tract,NS,carcinoma,squamous cell carcinoma	c.-3G>T	p.?	17:7675137-7675137	7

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Expression for Papillary Squamous Carcinoma

Search GEO for disease gene expression data for Papillary Squamous Carcinoma.

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Pathways for Papillary Squamous Carcinoma

Pathways related to Papillary Squamous Carcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Validated transcriptional targets of deltaNp63 isoforms ⁶¹	10.63	KRT5 CDKN2A
2	Bladder cancer ⁷⁴	10.23	EGFR CDKN2A

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GO Terms for Papillary Squamous Carcinoma

Biological processes related to Papillary Squamous Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of JNK cascade	GO:0046328	8.92	MAPK8IP1 EGFR

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Sources for Papillary Squamous Carcinoma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: PPL004 MIFTS: 34	Papillary Squamous Carcinoma Categories: Cancer diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
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