MCID: PPL004
MIFTS: 34

Papillary Squamous Carcinoma

Categories: Cancer diseases, Skin diseases
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Aliases & Classifications for Papillary Squamous Carcinoma

MalaCards integrated aliases for Papillary Squamous Carcinoma:

Name: Papillary Squamous Carcinoma 11 14
Papillary Squamous Cell Carcinoma 71
Papillary Epidermoid Carcinoma 11

Classifications:



External Ids:

Disease Ontology 11 DOID:4385
NCIt 49 C4102
SNOMED-CT 68 39056008
UMLS 71 C0334244

Summaries for Papillary Squamous Carcinoma

Disease Ontology: 11 A squamous cell carcinoma that has papillae, which are characterized either by narrow fibrovascular cores that superficially resemble papillary carcinoma of the urinary tract or by broad cores that contain edematous fibrous stroma with prominent capillaries and stromal inflammation.

MalaCards based summary: Papillary Squamous Carcinoma, also known as papillary squamous cell carcinoma, is related to hemometra and isthmus cancer. An important gene associated with Papillary Squamous Carcinoma is MAPK8IP1 (Mitogen-Activated Protein Kinase 8 Interacting Protein 1), and among its related pathways/superpathways are Validated transcriptional targets of deltaNp63 isoforms and Bladder cancer. The drugs Cisplatin and Nivolumab have been mentioned in the context of this disorder. Affiliated tissues include cervix, and related phenotype is Increased shRNA abundance (Z-score > 2).

Related Diseases for Papillary Squamous Carcinoma

Diseases related to Papillary Squamous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 332)
# Related Disease Score Top Affiliating Genes
1 hemometra 10.2 MAPK8IP1 INSM1
2 isthmus cancer 10.2 MAPK8IP1 INSM1
3 lymphocele 10.2 MAPK8IP1 INSM1
4 cervical incompetence 10.2 MAPK8IP1 INSM1
5 cervix small cell carcinoma 10.2 SYP MAPK8IP1
6 cervix erosion 10.2 MAPK8IP1 KRT5
7 anal canal squamous cell carcinoma 10.2 MAPK8IP1 KRT5
8 endometrial small cell carcinoma 10.2 SYP MAPK8IP1
9 pulmonary large cell neuroendocrine carcinoma 10.2 SYP INSM1
10 pulmonary neuroendocrine tumor 10.2 SYP INSM1
11 thymus basaloid carcinoma 10.2 SYP KRT5
12 cloacogenic carcinoma 10.2 SYP KRT5
13 squamous cell carcinoma 10.2
14 early invasive cervical adenocarcinoma 10.2 INSM1 CDKN2A
15 cervix endometriosis 10.2 MAPK8IP1 CDKN2A
16 tracheal cancer 10.2 SYP KRT5
17 cervical adenosquamous carcinoma 10.1 MAPK8IP1 CDKN2A
18 prostate signet ring cell adenocarcinoma 10.1 SYP KRT5
19 vulvar eccrine porocarcinoma 10.1 SYP CDKN2A
20 frontal lobe neoplasm 10.1 SYP EGFR
21 esophageal neuroendocrine tumor 10.1 SYP KRT5
22 fallopian tube endometrioid adenocarcinoma 10.1 INSM1 CDKN2A
23 chronic cervicitis 10.1 INSM1 CDKN2A
24 penile urethral cancer 10.1 KRT5 CDKN2A
25 spinal cord oligodendroglioma 10.1 SYP EGFR
26 gallbladder small cell carcinoma 10.1 SYP CDKN2A
27 pancreatoblastoma 10.1 SYP CDKN2A
28 cutaneous ganglioneuroma 10.1 SYP EGFR
29 lymphohistiocytoid mesothelioma 10.1 KRT5 CDKN2A
30 tonsillar pillar cancer 10.1 EGFR CDKN2A
31 breast malignant phyllodes tumor 10.1 KRT5 EGFR
32 pleomorphic xanthoastrocytoma 10.1 SYP CDKN2A
33 sarcomatoid mesothelioma 10.1 KRT5 CDKN2A
34 esophagus verrucous carcinoma 10.1 EGFR CDKN2A
35 acanthoma 10.1 KRT5 CDKN2A
36 synchronous bilateral breast carcinoma 10.1 KRT5 EGFR
37 cellular ependymoma 10.1 SYP EGFR
38 lobular neoplasia 10.0 KRT5 EGFR
39 hypertrophy of breast 10.0 KRT5 EGFR
40 pancreatic cystadenoma 10.0 SYP INSM1
41 idh-wildtype glioblastoma 10.0 EGFR CDKN2A
42 bone squamous cell carcinoma 10.0 EGFR CDKN2A
43 adult malignant schwannoma 10.0 EGFR CDKN2A
44 mixed glioma 10.0 EGFR CDKN2A
45 supratentorial cancer 10.0 SYP CDKN2A
46 inverted papilloma 10.0 KRT5 CDKN2A
47 vulva squamous cell carcinoma 10.0 EGFR CDKN2A
48 laryngeal benign neoplasm 10.0 EGFR CDKN2A
49 pulmonary blastoma 10.0 SYP EGFR
50 hypopharynx cancer 10.0 EGFR CDKN2A

Graphical network of the top 20 diseases related to Papillary Squamous Carcinoma:



Diseases related to Papillary Squamous Carcinoma

Symptoms & Phenotypes for Papillary Squamous Carcinoma

GenomeRNAi Phenotypes related to Papillary Squamous Carcinoma according to GeneCards Suite gene sharing:

25 (show all 22)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.7 INSM1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.7 EGFR
3 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.7 KRT5
4 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.7 KRT7
5 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.7 KRT5
6 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.7 INSM1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-162 9.7 INSM1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-17 9.7 KRT5
9 Increased shRNA abundance (Z-score > 2) GR00366-A-180 9.7 KRT5
10 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.7 KRT7
11 Increased shRNA abundance (Z-score > 2) GR00366-A-200 9.7 KRT5
12 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.7 EGFR
13 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.7 EGFR
14 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.7 EGFR
15 Increased shRNA abundance (Z-score > 2) GR00366-A-53 9.7 INSM1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.7 INSM1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-68 9.7 KRT7
18 Increased shRNA abundance (Z-score > 2) GR00366-A-72 9.7 KRT7
19 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.7 KRT7
20 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.7 EGFR
21 Increased shRNA abundance (Z-score > 2) GR00366-A-91 9.7 EGFR KRT5 KRT7
22 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.7 INSM1

Drugs & Therapeutics for Papillary Squamous Carcinoma

Drugs for Papillary Squamous Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2, Phase 3 15663-27-1 2767 5702198 441203
2
Nivolumab Approved Phase 2, Phase 3 946414-94-4
3 Immune Checkpoint Inhibitors Phase 2, Phase 3
4 Antineoplastic Agents, Immunological Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Phase II/III Trial of De-Intensified Radiation Therapy for Patients With Early-Stage, P16-Positive, Non-Smoking Associated Oropharyngeal Cancer Recruiting NCT03952585 Phase 2, Phase 3 Cisplatin

Search NIH Clinical Center for Papillary Squamous Carcinoma

Genetic Tests for Papillary Squamous Carcinoma

Anatomical Context for Papillary Squamous Carcinoma

Organs/tissues related to Papillary Squamous Carcinoma:

MalaCards : Cervix

Publications for Papillary Squamous Carcinoma

Articles related to Papillary Squamous Carcinoma:

# Title Authors PMID Year
1
Histopathologic risk factors in oral and oropharyngeal squamous cell carcinoma variants: an update with special reference to HPV-related carcinomas. 62
24880454 2014
2
HPV-related squamous cell carcinoma variants in the head and neck. 62
22782224 2012
3
De novo papillary squamous carcinoma of the lacrimal sac. 62
12753996 2003
4
Papillary squamous carcinoma: will the real one please stand up? 62
10640196 2000
5
Papillary immature metaplasia (immature condyloma) of the cervix: a clinicopathologic analysis and comparison with papillary squamous carcinoma. 62
9635687 1998
6
Results of the radiotherapeutic management of carcinoma of the cervix with emphasis on the influence of histologic classification. 62
3133103 1988
7
Inverting papilloma of the nose: analysis of 48 patients. 62
3599169 1987

Variations for Papillary Squamous Carcinoma

Cosmic variations for Papillary Squamous Carcinoma:

8 (show top 50) (show all 5642)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM107899595 TP63 urinary tract,NS,carcinoma,squamous cell carcinoma c.562A>C p.K188Q 3:189808509-189808509 7
2 COSM89456209 TP63 urinary tract,NS,carcinoma,squamous cell carcinoma c.280A>C p.K94Q 3:189808509-189808509 7
3 COSM90483663 TP63 urinary tract,NS,carcinoma,squamous cell carcinoma c.562A>C p.K188Q 3:189808509-189808509 7
4 COSM113477332 TP63 urinary tract,NS,carcinoma,squamous cell carcinoma c.42+18667A>C p.? 3:189808509-189808509 7
5 COSM88650776 TP63 urinary tract,NS,carcinoma,squamous cell carcinoma c.562A>C p.K188Q 3:189808509-189808509 7
6 COSM98198072 TP63 urinary tract,NS,carcinoma,squamous cell carcinoma c.280A>C p.K94Q 3:189808509-189808509 7
7 COSM104666843 TP63 urinary tract,NS,carcinoma,squamous cell carcinoma c.562A>C p.K188Q 3:189808509-189808509 7
8 COSM109398849 TP63 urinary tract,NS,carcinoma,squamous cell carcinoma c.280A>C p.K94Q 3:189808509-189808509 7
9 COSM98159381 TP63 urinary tract,NS,carcinoma,squamous cell carcinoma c.562A>C p.K188Q 3:189808509-189808509 7
10 COSM98183008 TP63 urinary tract,NS,carcinoma,squamous cell carcinoma c.280A>C p.K94Q 3:189808509-189808509 7
11 COSM114687375 TP63 urinary tract,NS,carcinoma,squamous cell carcinoma c.280A>C p.K94Q 3:189808509-189808509 7
12 COSM122751334 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.308A>G p.N103S 17:7674259-7674259 7
13 COSM93190467 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.874A>G p.K292E 17:7673746-7673746 7
14 COSM106053212 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.795G>C p.L265= 17:7673825-7673825 7
15 COSM144670184 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.694G>A p.E232K 17:7673809-7673809 7
16 COSM122271260 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.422G>A p.R141H 17:7673802-7673802 7
17 COSM143373275 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.722G>A p.R241K 17:7673781-7673781 7
18 COSM87898458 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.853G>A p.E285K 17:7673767-7673767 7
19 COSM143156898 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.376G>A p.E126K 17:7673767-7673767 7
20 COSM144325168 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.587A>G p.N196S 17:7674259-7674259 7
21 COSM121875871 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.461A>G p.E154G 17:7673763-7673763 7
22 COSM111771867 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.396G>C p.K132N 17:7675216-7675216 7
23 COSM93184755 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.586C>T p.R196* 17:7674945-7674945 7
24 COSM106055208 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.637C>T p.R213* 17:7674894-7674894 7
25 COSM105619860 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.524G>A p.R175H 17:7675088-7675088 7
26 COSM144028995 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.778G>A p.E260K 17:7673809-7673809 7
27 COSM144013089 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.785G>A p.R262H 17:7673802-7673802 7
28 COSM143944174 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.298G>A p.D100N 17:7674188-7674188 7
29 COSM111776584 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.811G>A p.E271K 17:7673809-7673809 7
30 COSM144096591 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.-82G>C p.? 17:7675216-7675216 7
31 COSM142755507 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.688A>T p.S230C 17:7673815-7673815 7
32 COSM144013682 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.811C>T p.R271W 17:7673776-7673776 7
33 COSM143943546 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.341G>A p.R114H 17:7673802-7673802 7
34 COSM143156608 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.47G>A p.R16H 17:7675088-7675088 7
35 COSM121889671 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.-1G>C p.? 17:7675216-7675216 7
36 COSM144088618 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.160C>T p.R54* 17:7674894-7674894 7
37 COSM142571831 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.279G>C p.K93N 17:7675216-7675216 7
38 COSM105627556 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.782+435A>G p.? 17:7673746-7673746 7
39 COSM143164052 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.-3G>T p.? 17:7675137-7675137 7
40 COSM143370575 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.701G>A p.R234H 17:7673802-7673802 7
41 COSM111758217 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.818G>A p.R273H 17:7673802-7673802 7
42 COSM106069985 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.811G>A p.E271K 17:7673809-7673809 7
43 COSM144670704 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.592A>G p.M198V 17:7674254-7674254 7
44 COSM144650760 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.701G>A p.R234H 17:7673802-7673802 7
45 COSM105639894 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.704A>G p.N235S 17:7674259-7674259 7
46 COSM143943820 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.336G>A p.E112= 17:7673807-7673807 7
47 COSM112255322 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.637C>T p.R213* 17:7674894-7674894 7
48 COSM121876050 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.326C>T p.S109F 17:7674241-7674241 7
49 COSM142837327 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.560G>A p.G187D 17:7674971-7674971 7
50 COSM144093356 TP53 urinary tract,NS,carcinoma,squamous cell carcinoma c.-3G>T p.? 17:7675137-7675137 7

Expression for Papillary Squamous Carcinoma

Search GEO for disease gene expression data for Papillary Squamous Carcinoma.

Pathways for Papillary Squamous Carcinoma

Pathways related to Papillary Squamous Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.63 KRT5 CDKN2A
2 10.23 EGFR CDKN2A

GO Terms for Papillary Squamous Carcinoma

Biological processes related to Papillary Squamous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of JNK cascade GO:0046328 8.92 MAPK8IP1 EGFR

Sources for Papillary Squamous Carcinoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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