MCID: PPL004
MIFTS: 39

Papillary Squamous Carcinoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Papillary Squamous Carcinoma

MalaCards integrated aliases for Papillary Squamous Carcinoma:

Name: Papillary Squamous Carcinoma 12 15
Papillary Squamous Cell Carcinoma 70
Papillary Epidermoid Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4385
NCIt 50 C4102
SNOMED-CT 67 39056008
UMLS 70 C0334244

Summaries for Papillary Squamous Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that has papillae, which are characterized either by narrow fibrovascular cores that superficially resemble papillary carcinoma of the urinary tract or by broad cores that contain edematous fibrous stroma with prominent capillaries and stromal inflammation.

MalaCards based summary : Papillary Squamous Carcinoma, also known as papillary squamous cell carcinoma, is related to early invasive cervical adenocarcinoma and thymus basaloid carcinoma. An important gene associated with Papillary Squamous Carcinoma is INSM1 (INSM Transcriptional Repressor 1), and among its related pathways/superpathways are Cell adhesion_Cell-matrix glycoconjugates and Photodynamic therapy-induced AP-1 survival signaling.. Affiliated tissues include cervix, tonsil and tongue, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Papillary Squamous Carcinoma

Diseases related to Papillary Squamous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 345)
# Related Disease Score Top Affiliating Genes
1 early invasive cervical adenocarcinoma 10.3 INSM1 CDKN2A
2 thymus basaloid carcinoma 10.3 SYP KRT5
3 esophageal neuroendocrine tumor 10.3 SYP KRT5
4 cloacogenic carcinoma 10.3 SYP KRT5
5 breast papillary carcinoma 10.3 SYP KRT5
6 acanthoma 10.3 KRT5 CDKN2A
7 penile urethral cancer 10.3 KRT5 CDKN2A
8 male urethral cancer 10.3 KRT5 CDKN2A
9 fallopian tube endometrioid adenocarcinoma 10.2 INSM1 CDKN2A
10 ovary neuroendocrine neoplasm 10.2 SYP KRT7
11 gallbladder small cell carcinoma 10.2 SYP KRT7
12 ureter small cell carcinoma 10.2 SYP KRT7
13 rectum neuroendocrine neoplasm 10.2 SYP KRT7
14 middle ear adenoma 10.2 SYP KRT7
15 ureter squamous cell carcinoma 10.2 KRT7 KRT5
16 papillary thymic adenocarcinoma 10.2 SYP CEACAM5
17 gliofibroma 10.2 SYP CDKN2A
18 mucoepidermoid esophageal carcinoma 10.2 KRT5 CEACAM5
19 gastric small cell carcinoma 10.2 SYP CEACAM5
20 jejunal neoplasm 10.2 SYP KRT7
21 ceruminoma 10.2 KRT7 KRT5
22 ovarian large-cell neuroendocrine carcinoma 10.2 SYP KRT7
23 esophageal adenoid cystic carcinoma 10.2 SYP CEACAM5
24 uterus carcinoma in situ 10.2 INSM1 CDKN2A
25 appendix adenocarcinoma 10.2 SYP KRT7
26 subareolar duct papillomatosis 10.2 KRT7 KRT5
27 breast cystic hypersecretory carcinoma 10.2 KRT5 CEACAM5
28 meibomian cyst 10.2 SYP KRT7
29 nipple benign neoplasm 10.2 KRT7 KRT5
30 gallbladder squamous cell carcinoma 10.2 KRT5 CEACAM5
31 cervix uteri carcinoma in situ 10.2 INSM1 CDKN2A
32 thymus adenocarcinoma 10.2 KRT5 CEACAM5
33 ceruminous adenocarcinoma 10.2 KRT7 KRT5
34 myoblastoma 10.2 SYP CEACAM5
35 ureteral benign neoplasm 10.2 SYP KRT7
36 ovarian germ cell teratoma 10.2 SYP KRT7
37 lung clear cell carcinoma 10.2 KRT7 KRT5
38 cervical basaloid squamous cell carcinoma 10.2 KRT7 CDKN2A
39 colon leiomyosarcoma 10.2 KRT5 CEACAM5
40 necrotizing sialometaplasia 10.2 KRT7 KRT5
41 gastric squamous cell carcinoma 10.2 KRT7 KRT5
42 vaginal adenoma 10.2 SYP KRT7
43 parotid gland adenoid cystic carcinoma 10.2 CEACAM5 CDKN2A
44 colon neuroendocrine neoplasm 10.2 SYP CEACAM5
45 vaginal benign neoplasm 10.2 SYP KRT7
46 anal canal paget's disease 10.2 KRT7 CDKN2A
47 squamous cell bile duct carcinoma 10.2 KRT7 KRT5
48 middle ear adenocarcinoma 10.2 KRT7 KRT5
49 breast mucinous carcinoma 10.2 KRT7 KRT5
50 balloon cell malignant melanoma 10.2 KRT7 KRT5

Graphical network of the top 20 diseases related to Papillary Squamous Carcinoma:



Diseases related to Papillary Squamous Carcinoma

Symptoms & Phenotypes for Papillary Squamous Carcinoma

GenomeRNAi Phenotypes related to Papillary Squamous Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-118 9.56 EGFR
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.56 KRT5
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-182 9.56 KRT5
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-190 9.56 EGFR
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-58 9.56 EGFR
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.56 KRT5 KRT7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.56 INSM1
8 Decreased viability with paclitaxel GR00179-A-1 9.02 BCL2L1 EGFR
9 Decreased viability with paclitaxel GR00179-A-2 9.02 BCL2L1
10 Decreased viability with paclitaxel GR00179-A-3 9.02 BCL2L1 EGFR

Drugs & Therapeutics for Papillary Squamous Carcinoma

Search Clinical Trials , NIH Clinical Center for Papillary Squamous Carcinoma

Genetic Tests for Papillary Squamous Carcinoma

Anatomical Context for Papillary Squamous Carcinoma

MalaCards organs/tissues related to Papillary Squamous Carcinoma:

40
Cervix, Tonsil, Tongue, Trachea

Publications for Papillary Squamous Carcinoma

Articles related to Papillary Squamous Carcinoma:

(show top 50) (show all 99)
# Title Authors PMID Year
1
Treatment of canine oral papillary squamous cell carcinoma using definitive-intent radiation as a monotherapy-a case series. 61
32975025 2021
2
Papillary Squamous Cell Carcinoma of the Uterine Cervix: Biopsy Samples Frequently Underrepresent the Presence of Stromal Invasion. 61
33323853 2020
3
Recurrent vaginal intraepithelial neoplasia successfully treated with topical imiquimod: A case report. 61
32754333 2020
4
Pulmonary papillary squamous cell carcinoma: a population-based analysis of incidence, treatment, and prognosis. 61
31737312 2019
5
Verruciform and Condyloma-like Squamous Proliferations in the Anogenital Region. 61
30203987 2019
6
HPV-Related Papillary Lesions of the Oral Mucosa: A Review. 61
30693456 2019
7
Oral carcinoma cuniculatum, an unacquainted variant of oral squamous cell carcinoma: A systematic review. 61
30607347 2018
8
Combined External, Endoscopic, Endonasal-Assisted En Bloc Resection of Malignant Tumors From the Lacrimal Drainage System. 61
29944561 2018
9
HPV-related papillary squamous cell carcinoma of the tonsil during treatment with fingolimod. 61
29734135 2018
10
Unusual Papillary Squamous Cell Carcinoma of the Tip of Tongue Presenting in a Patient Status Post Heart Transplant. 61
29970551 2018
11
Immunohistochemical Characterization of Canine Oral Papillary Squamous Cell Carcinoma. 61
29262763 2018
12
The clinical application of tumor markers in the screening of malignancies and interstitial lung disease of dermatomyositis/polymyositis patients: A retrospective study. 61
29977547 2018
13
Injectable Chemotherapy Downstaged Oral Squamous Cell Carcinoma from Nonresectable to Resectable in a Rescue Dog: Diagnosis, Treatment, and Outcome. 61
30402324 2018
14
Proliferative endophytic lesion of the maxilla: A diagnostic challenge. 61
29491613 2018
15
Papillary squamous cell carcinoma of the palatine tonsil: a rare cancer of the head and neck. 61
28530265 2017
16
Diagnosis and treatment of cervical papillary squamous cell carcinoma with unknown depth of stromal invasion. 61
28504849 2017
17
Squamous cell carcinoma of the upper aerodigestive tract: dysplasia and select variants. 61
28060368 2017
18
Papillary squamous cell carcinoma of the cervix: Two cases and a review of the literature. 61
27790636 2016
19
Papillary Squamous Cell Carcinoma of the Cheek. 61
27228376 2016
20
Exophytic Verrucous Hyperplasia of the Oral Cavity – Application of Standardized Criteria for Diagnosis from a Consensus Report 61
27865210 2016
21
Role of FNA cytology with cell block in the diagnosis of papillary squamous cell carcinoma of the upper aero-digestive tract: case report. 61
25303677 2015
22
Immunohistochemical findings and differential diagnosis of papillary-type cutaneous verrucous carcinoma of the neck: A case report. 61
26788215 2015
23
Laryngeal Papillary Squamous Cell Carcinoma: A Population-Based Analysis of Incidence and Survival. 61
25917664 2015
24
Clinical approaches to treating papillary squamous cell carcinoma of the uterine cervix. 61
25348708 2014
25
PROSE scleral lens: a novel aid for staged eyelid reconstruction. 61
24317103 2014
26
Histopathologic risk factors in oral and oropharyngeal squamous cell carcinoma variants: an update with special reference to HPV-related carcinomas. 61
24880454 2014
27
Squamous cell carcinoma variants of the upper aerodigestive tract: a comprehensive review with a focus on genetic alterations. 61
24878013 2014
28
Cutaneous papillary squamous cell carcinoma. 61
24667669 2014
29
Oral papillary squamous cell carcinoma in twelve dogs. 61
24016780 2014
30
Papillary squamous cell carcinoma of antrum-clear cell variant. 61
24959058 2014
31
Papillary variant of squamous cell carcinoma arising on the gingiva: 61 cases reported from within a larger series of gingival squamous cell carcinoma. 61
23620148 2013
32
Bilateral squamous cell carcinoma of the lacrimal sac. 61
24217491 2013
33
Comparison between p16 INK4A immunohistochemistry and human papillomavirus polymerase chain reaction assay in oral papillary squamous cell carcinoma. 61
23706276 2013
34
Papillary squamous cell carcinoma of the head and neck: clinicopathologic and molecular features with special reference to human papillomavirus. 61
23797720 2013
35
CD44 expression in intraoral salivary ductal papillomas and oral papillary squamous cell carcinoma. 61
23143465 2013
36
Papillary squamous cell carcinoma of the oral mucosa: a clinicopathologic and immunohistochemical study of 12 cases and literature review. 61
22672806 2013
37
Human papillomavirus infection and papillary squamous cell carcinoma in the head and neck region. 61
23065573 2013
38
Papillary squamous cell carcinoma of the trachea associated with human papillomavirus-18 infection. 61
24334586 2013
39
Clinical, histologic, and computed tomographic features of oral papillary squamous cell carcinoma in dogs: 9 cases (2008- 2011). 61
23757821 2013
40
Pigmented viral-associated conjunctival carcinoma. 61
23762697 2013
41
Clinicopathologic features of oral squamous papilloma and papillary squamous cell carcinoma: a study of 197 patients from eastern China. 61
22627075 2012
42
HPV-related squamous cell carcinoma variants in the head and neck. 61
22782224 2012
43
Basaloid squamous cell carcinoma of the penis with papillary features: a clinicopathologic study of 12 cases. 61
22367299 2012
44
Mandibular cuniculatum carcinoma: apropos of 3 cases and literature review. 61
20665733 2012
45
Papillary squamous cell carcinoma of the mandibular gingiva. 61
22977668 2012
46
[Long term results of partial laryngectomies in patients suffering from laryngeal cancer]. 61
22381015 2012
47
Papillary squamous cell carcinoma of the head and neck: a clinicopathologic series. 61
21035908 2011
48
Papillary squamous cell carcinoma of the larynx. 61
21853426 2011
49
[Three cases of primary squamous cell carcinoma in the frontal sinus]. 61
22169549 2011
50
Papillary squamous cell carcinoma of the oral cavity with acantholytic and pseudovascular features. 61
22135728 2011

Variations for Papillary Squamous Carcinoma

Cosmic variations for Papillary Squamous Carcinoma:

9 (show top 50) (show all 5642)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM84510685 ZNF276 urinary tract,upper urinary tract,carcinoma,NS c.*420C>T p.? 16:89738666-89738666 3
2 COSM102034006 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.7070C>T p.T2357M 16:72788464-72788464 3
3 COSM149314765 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.9829C>T p.P3277S 16:72788447-72788447 3
4 COSM87290232 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.9829C>T p.P3277S 16:72788447-72788447 3
5 COSM102022922 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.2903T>A p.I968N 16:72797037-72797037 3
6 COSM87284313 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.6608G>A p.R2203H 16:72796074-72796074 3
7 COSM149282136 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.8029G>A p.E2677K 16:72794653-72794653 3
8 COSM102042654 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.-23-9030G>A p.? 16:72959995-72959995 3
9 COSM149268190 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.5645T>A p.I1882N 16:72797037-72797037 3
10 COSM149297301 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.9812C>T p.T3271M 16:72788464-72788464 3
11 COSM149321603 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.9964C>T p.Q3322* 16:72788312-72788312 3
12 COSM87286411 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.5886G>T p.E1962D 16:72796796-72796796 3
13 COSM102036900 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.2138C>T p.A713V 16:72797802-72797802 3
14 COSM102025882 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.-23-6951C>T p.? 16:72957916-72957916 3
15 COSM149265910 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.8849G>A p.R2950H 16:72793833-72793833 3
16 COSM87273255 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.8849G>A p.R2950H 16:72793833-72793833 3
17 COSM149304877 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.4880C>T p.A1627V 16:72797802-72797802 3
18 COSM87274117 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.308G>A p.R103H 16:72959838-72959838 3
19 COSM87283980 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.9812C>T p.T3271M 16:72788464-72788464 3
20 COSM102028034 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.4168C>T p.Q1390* 16:72795772-72795772 3
21 COSM102031079 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.8084C>T p.S2695F 16:72787450-72787450 3
22 COSM102042631 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.7273G>C p.E2425Q 16:72788261-72788261 3
23 COSM149298321 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.6608G>A p.R2203H 16:72796074-72796074 3
24 COSM87286419 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.4880C>T p.A1627V 16:72797802-72797802 3
25 COSM149319996 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.151G>A p.D51N 16:72959995-72959995 3
26 COSM87274102 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.5645T>A p.I1882N 16:72797037-72797037 3
27 COSM87286936 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.10573G>A p.G3525S 16:72787703-72787703 3
28 COSM149306658 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.10573G>A p.G3525S 16:72787703-72787703 3
29 COSM87281241 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.10826C>T p.S3609F 16:72787450-72787450 3
30 COSM87292033 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.7253C>T p.T2418I 16:72795429-72795429 3
31 COSM102043266 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.7222C>T p.Q2408* 16:72788312-72788312 3
32 COSM102036905 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.2075G>A p.S692N 16:72797865-72797865 3
33 COSM149304885 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.4817G>A p.S1606N 16:72797865-72797865 3
34 COSM149283576 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.6910C>T p.Q2304* 16:72795772-72795772 3
35 COSM149290589 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.10826C>T p.S3609F 16:72787450-72787450 3
36 COSM102034726 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.3866G>A p.R1289H 16:72796074-72796074 3
37 COSM87277269 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.2230C>T p.H744Y 16:72957916-72957916 3
38 COSM102035724 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.-23-9132G>A p.? 16:72960097-72960097 3
39 COSM102022936 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.-23-8873G>A p.? 16:72959838-72959838 3
40 COSM102027521 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.5287G>A p.E1763K 16:72794653-72794653 3
41 COSM87292018 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.10015G>C p.E3339Q 16:72788261-72788261 3
42 COSM102036892 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.3144G>T p.E1048D 16:72796796-72796796 3
43 COSM102037442 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.7831G>A p.G2611S 16:72787703-72787703 3
44 COSM87278976 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.6910C>T p.Q2304* 16:72795772-72795772 3
45 COSM87292630 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.9964C>T p.Q3322* 16:72788312-72788312 3
46 COSM102040500 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.7087C>T p.P2363S 16:72788447-72788447 3
47 COSM149319982 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.7253C>T p.T2418I 16:72795429-72795429 3
48 COSM149304868 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.5886G>T p.E1962D 16:72796796-72796796 3
49 COSM102042649 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.4511C>T p.T1504I 16:72795429-72795429 3
50 COSM149268207 ZFHX3 urinary tract,upper urinary tract,carcinoma,NS c.308G>A p.R103H 16:72959838-72959838 3

Expression for Papillary Squamous Carcinoma

Search GEO for disease gene expression data for Papillary Squamous Carcinoma.

Pathways for Papillary Squamous Carcinoma

Pathways related to Papillary Squamous Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.55 ELN CEACAM5
2 10.51 EGFR CDKN2A BCL2L1

GO Terms for Papillary Squamous Carcinoma

Biological processes related to Papillary Squamous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell cycle arrest GO:0071158 9.16 INSM1 CDKN2A
2 negative regulation of anoikis GO:2000811 8.96 CEACAM5 BCL2L1
3 apoptotic mitochondrial changes GO:0008637 8.62 CDKN2A BCL2L1

Sources for Papillary Squamous Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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