MCID: PPL035
MIFTS: 40

Papillary Thyroid Microcarcinoma

Categories: Cancer diseases

Aliases & Classifications for Papillary Thyroid Microcarcinoma

MalaCards integrated aliases for Papillary Thyroid Microcarcinoma:

Name: Papillary Thyroid Microcarcinoma 57 29 55 73

Classifications:



External Ids:

OMIM 57 603744
MedGen 42 C1709457
UMLS 73 C1709457

Summaries for Papillary Thyroid Microcarcinoma

MalaCards based summary : Papillary Thyroid Microcarcinoma is related to ovarian germ cell teratoma and thyroid cancer, nonmedullary, 1. An important gene associated with Papillary Thyroid Microcarcinoma is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways/superpathways are MAPK signaling pathway and Gastric cancer. The drugs Ethanol and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lymph node and endothelial, and related phenotypes are cellular and cardiovascular system

Description from OMIM: 603744

Related Diseases for Papillary Thyroid Microcarcinoma

Diseases related to Papillary Thyroid Microcarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 ovarian germ cell teratoma 31.1 NKX2-1 TG
2 thyroid cancer, nonmedullary, 1 30.8 BRAF NKX2-1 TG
3 thyroiditis 30.6 CALCA TG TSHR
4 struma ovarii 29.7 BRAF NKX2-1 TG TSHR
5 endemic goiter 29.1 CALCA TG TSHR
6 goiter 29.0 CALCA NKX2-1 TG TSHR
7 hypothyroidism 28.6 CALCA NKX2-1 TG TSHR
8 ovarian germ cell cancer 10.8 NKX2-1 TG
9 spitz nevus 10.7 BRAF MKI67
10 malignant teratoma 10.7 NKX2-1 TG
11 malignant struma ovarii 10.7 NKX2-1 TG
12 hemangioma of lung 10.7 NKX2-1 TP63
13 benign breast phyllodes tumor 10.6 MKI67 TP63
14 ameloblastic carcinoma 10.6 MKI67 TP63
15 newborn respiratory distress syndrome 10.6 BRAF NKX2-1
16 deafness, autosomal recessive 39 10.4 HGF MET
17 deafness, autosomal recessive 97 10.4 HGF MET
18 hidradenocarcinoma 10.4 MKI67 NKX2-1 TP63
19 acral lentiginous melanoma 10.4 BRAF MET
20 benign struma ovarii 10.4 TG TSHR
21 neonatal hypothyroidism 10.4 TG TSHR
22 endometrial squamous cell carcinoma 10.3 HGF MET
23 large cell medulloblastoma 10.3 HGF MET
24 doxorubicin induced cardiomyopathy 10.3 HGF MET
25 cervicitis 10.2
26 craniopharyngioma 10.2 BRAF EPCAM MKI67
27 childhood hepatocellular carcinoma 10.2 EPCAM MET
28 mucoepidermoid thyroid carcinoma 10.2 CALCA TG
29 graves disease 1 10.2 TG TSHR
30 suppurative thyroiditis 10.1 CALCA TG
31 thyroid sarcoma 10.1 CALCA TG
32 athyreosis 10.1 NKX2-1 TG TSHR
33 myxedema 10.1 TG TSHR
34 hypothyroidism, congenital, nongoitrous, 2 10.1 NKX2-1 TG TSHR
35 atypical follicular adenoma 10.1 CALCA TG
36 aging 10.1
37 congenital hypothyroidism 10.1 NKX2-1 TG TSHR
38 toxic diffuse goiter 10.1 TG TSHR
39 necrotizing sialometaplasia 10.1 MKI67 TP63
40 subacute thyroiditis 10.0 TG TSHR
41 acute thyroiditis 10.0 CALCA TG
42 hypoadrenalism 10.0 CALCA TG
43 anaplastic thyroid cancer 10.0 BRAF MET NKX2-1 TG
44 thyroid hormone resistance, generalized, autosomal dominant 9.9
45 adrenocortical carcinoma, hereditary 9.9
46 lymphoma 9.9
47 nodal marginal zone lymphoma 9.9
48 esophagitis 9.9
49 squamous cell carcinoma 9.9
50 teratoma 9.9

Graphical network of the top 20 diseases related to Papillary Thyroid Microcarcinoma:



Diseases related to Papillary Thyroid Microcarcinoma

Symptoms & Phenotypes for Papillary Thyroid Microcarcinoma

Clinical features from OMIM:

603744

MGI Mouse Phenotypes related to Papillary Thyroid Microcarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.02 HGF IDO1 MET NKX2-1 NQO1 TP63
2 cardiovascular system MP:0005385 10.01 BRAF CRKL EPCAM HGF IDO1 MET
3 growth/size/body region MP:0005378 9.96 BRAF CRKL EPCAM HGF MET NKX2-1
4 endocrine/exocrine gland MP:0005379 9.92 BRAF CRKL EPCAM MET NKX2-1 TG
5 hematopoietic system MP:0005397 9.76 BRAF CRKL EPCAM HGF IDO1 NQO1
6 neoplasm MP:0002006 9.5 BRAF CRKL MET NKX2-1 NQO1 TP63
7 no phenotypic analysis MP:0003012 9.1 EPCAM HGF MET MKI67 NKX2-1 TP63

Drugs & Therapeutics for Papillary Thyroid Microcarcinoma

Drugs for Papillary Thyroid Microcarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Not Applicable 64-17-5 702
2
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
3 Central Nervous System Depressants Not Applicable
4 Anesthetics Not Applicable
5 Anti-Infective Agents Not Applicable
6 Anti-Infective Agents, Local Not Applicable

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Prophylactic Central Lymph Node Dissection in Papillary Thyroid Microcarcinoma Completed NCT00795782 Phase 3
2 Extent of Central Lymph Node Dissection in Papillary Thyroid Microcarcinoma Recruiting NCT01149161 Phase 2, Phase 3
3 Percutaneous Ethanol Injection for Primary Papillary Thyroid Microcarcinoma Unknown status NCT01974284 Not Applicable percutaneous ethanol ablation
4 Genetic Expression Alteration Affect on Lateral Neck Node Metastasis of Thyroid Papillary Microcarcinoma : Microarray Analysis Unknown status NCT01384669
5 Long-term Outcomes of Total Thyroidectomy Versus Less Than Total Thyroidectomy for Papillary Thyroid Microcarcinoma Completed NCT01648569
6 Active Surveillance of Papillary Thyroid Microcarcinoma Recruiting NCT02609685 Not Applicable
7 Active Surveillance of Papillary Thyroid Microcarcinoma Recruiting NCT02952612
8 Active Surveillance on Papillary Thyroid Microcarcinoma Recruiting NCT02938702
9 A Multicenter Trial of PLA vs. Surgery for Treating PTMC Recruiting NCT03377829 Not Applicable
10 Evaluation of Central Compartment Dissection Without Thyroidectomy Recruiting NCT03454464 Not Applicable
11 Radiofrequency Ablation of Low Risk Papillary Thyroid Microcarcinoma Not yet recruiting NCT03432299 Not Applicable
12 A Trial Comparing USG-HIFU vs AS in Management of Low-risk PTMC Not yet recruiting NCT03327636 Not Applicable
13 Targeted-sequencing of PTC in Different Stages Not yet recruiting NCT03214978

Search NIH Clinical Center for Papillary Thyroid Microcarcinoma

Genetic Tests for Papillary Thyroid Microcarcinoma

Genetic tests related to Papillary Thyroid Microcarcinoma:

# Genetic test Affiliating Genes
1 Papillary Thyroid Microcarcinoma 29

Anatomical Context for Papillary Thyroid Microcarcinoma

MalaCards organs/tissues related to Papillary Thyroid Microcarcinoma:

41
Thyroid, Lymph Node, Endothelial, T Cells

Publications for Papillary Thyroid Microcarcinoma

Articles related to Papillary Thyroid Microcarcinoma:

(show top 50) (show all 111)
# Title Authors Year
1
Interstitial fibrosis in papillary thyroid microcarcinoma and its association with biological behavior. ( 29552130 )
2018
2
Diagnostic value of ultrasound features and sex of fetuses in female patients with papillary thyroid microcarcinoma. ( 29760433 )
2018
3
Clinical predictors of lymph node metastasis and survival rate in papillary thyroid microcarcinoma: analysis of 3607 patients at a single institution. ( 29229118 )
2018
4
Impact of major different variants of papillary thyroid microcarcinoma on the clinicopathological characteristics: the study of 1041 cases. ( 28744725 )
2018
5
The role of diagnostic <sup>131</sup>I-SPECT/TC in patients with papillary thyroid microcarcinoma in long-term follow-up. ( 29496990 )
2018
6
The anteroposterior diameter of nodules in the risk assessment of papillary thyroid microcarcinoma. ( 29517693 )
2018
7
Is advocacy for active surveillance over definitive intervention in papillary thyroid microcarcinoma applicable to European patients? ( 29770318 )
2018
8
Sonographic features of papillary thyroid microcarcinoma predicting high-volume central neck lymph node metastasis. ( 29937168 )
2018
9
Long-term efficacy of ultrasound-guided low power microwave ablation for the treatment of primary papillary thyroid microcarcinoma: a 3-year follow-up study. ( 29427209 )
2018
10
Multifocality is associated with central neck lymph node metastases in papillary thyroid microcarcinoma. ( 29942154 )
2018
11
CORRIGENDUM FOR &amp;quot;High Serum TSH Level Is Associated With Progression of Papillary Thyroid Microcarcinoma During Active Surveillance&amp;quot;. ( 29538759 )
2018
12
Ultrasonography is valuable in evaluation of papillary thyroid microcarcinoma based on 5 mm tumor size. ( 29970683 )
2018
13
Ultrasound-guided percutaneous microwave ablation versus surgery for papillary thyroid microcarcinoma. ( 29637797 )
2018
14
A favorable tumor size to define papillary thyroid microcarcinoma: an analysis of 1176 consecutive cases. ( 29740219 )
2018
15
Nomogram for predicting central lymph node metastasis in papillary thyroid microcarcinoma: A retrospective cohort study of 8668 patients. ( 29803769 )
2018
16
Clinical-pathological Characteristics and Prognostic Factors for Papillary Thyroid Microcarcinoma in the Elderly. ( 29344271 )
2018
17
Clinical analysis of cervical lymph node metastasis risk factors in patients with papillary thyroid microcarcinoma. ( 29876836 )
2018
18
A retrospective study of the clinical features in papillary thyroid microcarcinoma depending on age. ( 29762261 )
2018
19
Papillary thyroid microcarcinoma: characteristics at presentation, and evaluation of clinical and histological features associated with a worse prognosis in a Latin American cohort. ( 29694628 )
2018
20
Active Surveillance of Papillary Thyroid Microcarcinoma: A Mini-Review from Korea (Endocrinol Metab 2017;32:399-406, Tae Yong Kim et al.). ( 29589395 )
2018
21
Improved outcomes for papillary thyroid microcarcinoma care: active surveillance and case volume. ( 29977496 )
2018
22
High Serum TSH Level Is Associated With Progression of Papillary Thyroid Microcarcinoma During Active Surveillance. ( 29211863 )
2018
23
Patients' experiences of diagnosis and management of papillary thyroid microcarcinoma: a qualitative study. ( 29499654 )
2018
24
Papillary thyroid microcarcinoma in super obese patient. ( 29923487 )
2018
25
Study Protocol of Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma (MAeSTro). ( 29947183 )
2018
26
Active Surveillance of Papillary Thyroid Microcarcinoma: A Mini-Review from Korea. ( 29271613 )
2017
27
Lack of Efficacy of Radioiodine Remnant Ablation for Papillary Thyroid Microcarcinoma: Verification Using Inverse Probability of Treatment Weighting. ( 28600731 )
2017
28
Papillary Thyroid Microcarcinoma Arising Within a Mature Ovarian Teratoma: Case Report and Review of the Literature. ( 28615984 )
2017
29
Transoral endoscopic thyroidectomy for papillary thyroid microcarcinoma: initial experience of a single surgeon. ( 28835882 )
2017
30
Independent Risk Factors Predicting Central Lymph Node Metastasis in Papillary Thyroid Microcarcinoma. ( 28351086 )
2017
31
Hashimoto's Thyroiditis is an Important Risk Factor of Papillary Thyroid Microcarcinoma in Younger Adults. ( 28859207 )
2017
32
Clinical and pathologic predictors of central lymph node metastasis in papillary thyroid microcarcinoma: a retrospective cohort study. ( 28884301 )
2017
33
[Factors for lymph node metastasis and survival rate in papillary thyroid microcarcinoma: from a large cohort of 3 607 cases series]. ( 28441803 )
2017
34
Preoperative prediction of papillary thyroid microcarcinoma via multiparameter ultrasound. ( 28194993 )
2017
35
Diagnostic accuracy of ultrasonographic features for lymph node metastasis in papillary thyroid microcarcinoma: a single-center retrospective study. ( 28125992 )
2017
36
2016 Chinese expert consensus and guidelines for the diagnosis and treatment of papillary thyroid microcarcinoma. ( 28948061 )
2017
37
Clinical outcomes after delayed thyroid surgery in patients with papillary thyroid microcarcinoma. ( 28432268 )
2017
38
Papillary thyroid microcarcinoma: decision-making, extent of surgery, and outcomes. ( 28985856 )
2017
39
Risk factors for lymph node metastasis (LNM) in patients with papillary thyroid microcarcinoma (PTMC): role of preoperative ultrasound. ( 28534700 )
2017
40
Cyclin D1, Ret and P27 Expression in Papillary Thyroid Microcarcinoma ( 29120119 )
2017
41
MiR-324-5p assists ultrasonography in predicting lymph node metastasis of unifocal papillary thyroid microcarcinoma without extracapsular spread. ( 29137384 )
2017
42
Contrastive study of two screening criteria for active surveillance in patients with low-risk papillary thyroid microcarcinoma: a retrospective analysis of 1001 patients. ( 29029476 )
2017
43
Radioactive Iodine Ablation Decrease Recurrences in Papillary Thyroid Microcarcinoma with Lateral Lymph Node Metastasis in Chinese Patients. ( 28741199 )
2017
44
Risk factors for predicting central lymph node metastasis in papillary thyroid microcarcinoma (CN0): a study of 273 resections. ( 28975988 )
2017
45
Preoperative predictors of lateral neck lymph node metastasis in papillary thyroid microcarcinoma. ( 28272218 )
2017
46
Partial thyroidectomy for papillary thyroid microcarcinoma: Is completion total thyroidectomy indicated? ( 28506411 )
2017
47
Clinicopathologic Factors and Thyroid Nodule Sonographic Features for Predicting Central Lymph Node Metastasis in Papillary Thyroid Microcarcinoma: A Retrospective Study of 1204 Patients. ( 27794131 )
2016
48
Detection of Tumor Multifocality Is Important for Prediction of Tumor Recurrence in Papillary Thyroid Microcarcinoma: A Retrospective Study and Meta-Analysis. ( 27271109 )
2016
49
Clinicopathological Features and Prognosis of Papillary Thyroid Microcarcinoma for Surgery and Relationships with the BRAFV600E Mutational Status and Expression of Angiogenic Factors. ( 27936049 )
2016
50
Sonographic and Clinical Features of Papillary Thyroid Microcarcinoma Less than or Equal to Five Millimeters: A Retrospective Study. ( 26881783 )
2016

Variations for Papillary Thyroid Microcarcinoma

Expression for Papillary Thyroid Microcarcinoma

Search GEO for disease gene expression data for Papillary Thyroid Microcarcinoma.

Pathways for Papillary Thyroid Microcarcinoma

Pathways related to Papillary Thyroid Microcarcinoma according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1 12.46 BRAF CRKL HGF MET
2
Show member pathways
12.44 BRAF HGF MET NQO1
3
Show member pathways
12.4 BRAF CRKL HGF MET
4 12.38 BRAF CRKL HGF MET NQO1
5
Show member pathways
12.36 BRAF CRKL HGF MET
6
Show member pathways
12.07 BRAF CRKL HGF MET
7 11.7 HGF MET TP63
8 11.05 EPCAM HGF MET TP63
9 10.99 HGF MET
10 10.66 HGF MET TSHR
11 10.6 HGF MET
12 9.93 TG TSHR

GO Terms for Papillary Thyroid Microcarcinoma

Biological processes related to Papillary Thyroid Microcarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.72 BRAF HGF MET NQO1 TP63
2 cell proliferation GO:0008283 9.71 HGF MET MKI67 TP63
3 aging GO:0007568 9.65 CALCA NQO1 TP63
4 anatomical structure formation involved in morphogenesis GO:0048646 9.46 NKX2-1 TP63
5 establishment of skin barrier GO:0061436 9.43 MET TP63
6 pattern specification process GO:0007389 9.43 CRKL NKX2-1 TP63
7 hepatocyte growth factor receptor signaling pathway GO:0048012 9.37 HGF MET
8 animal organ morphogenesis GO:0009887 9.26 BRAF CRKL NKX2-1 TP63
9 negative regulation of hydrogen peroxide-mediated programmed cell death GO:1901299 9.16 HGF MET
10 thyroid gland development GO:0030878 8.8 BRAF NKX2-1 TG

Molecular functions related to Papillary Thyroid Microcarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.17 BRAF CALCA CRKL HGF MET NQO1
2 protein-containing complex binding GO:0044877 9.13 CALCA EPCAM TSHR

Sources for Papillary Thyroid Microcarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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