MCID: PPL035
MIFTS: 39

Papillary Thyroid Microcarcinoma

Categories: Cancer diseases

Aliases & Classifications for Papillary Thyroid Microcarcinoma

MalaCards integrated aliases for Papillary Thyroid Microcarcinoma:

Name: Papillary Thyroid Microcarcinoma 57 29 54 70

Classifications:



External Ids:

OMIM® 57 603744
MedGen 41 C1709457
UMLS 70 C1709457

Summaries for Papillary Thyroid Microcarcinoma

MalaCards based summary : Papillary Thyroid Microcarcinoma is related to thyroid carcinoma and thyroiditis. An important gene associated with Papillary Thyroid Microcarcinoma is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways/superpathways are MAPK signaling pathway and Gastric cancer. The drugs Lidocaine and Parathyroid hormone have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lymph node and breast, and related phenotypes are cellular and growth/size/body region

More information from OMIM: 603744

Related Diseases for Papillary Thyroid Microcarcinoma

Diseases related to Papillary Thyroid Microcarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 147)
# Related Disease Score Top Affiliating Genes
1 thyroid carcinoma 31.6 TSHR TG NKX2-1 CALCA BRAF
2 thyroiditis 31.6 TSHR TG CALCA
3 goiter 31.1 TSHR TG NKX2-1 CALCA
4 hashimoto thyroiditis 31.0 TSHR TG CALCA BRAF
5 hyperthyroidism 30.8 TSHR TG CALCA
6 thyroid gland disease 30.8 TSHR TG NKX2-1 CALCA
7 hypothyroidism 30.8 TSHR TG NKX2-1 CALCA BRAF
8 endemic goiter 30.6 TSHR TG CALCA
9 thyroid gland medullary carcinoma 30.6 TG NKX2-1 CALCA
10 ovarian germ cell teratoma 30.5 TG NKX2-1
11 nodular goiter 30.5 TSHR TG HGF CALCA BRAF
12 multinodular goiter 30.5 TSHR TG NKX2-1 CALCA
13 ovarian germ cell cancer 30.5 TG NKX2-1
14 struma ovarii 30.4 TSHR TG NKX2-1 BRAF
15 thyroid carcinoma, familial medullary 30.4 TG NKX2-1 CALCA BRAF
16 adenoma 30.3 TSHR TG MKI67 BRAF
17 differentiated thyroid carcinoma 30.2 TSHR TG NKX2-1 MET BRAF
18 squamous cell carcinoma 29.8 TP63 MKI67 EPCAM BRAF
19 papillary carcinoma 29.8 TSHR TP63 TG NKX2-1 MET HGF
20 thyroid gland follicular carcinoma 29.5 TSHR TG NKX2-1 MET CALCA BRAF
21 thyroid gland anaplastic carcinoma 29.5 TSHR TG NKX2-1 MET CALCA BRAF
22 follicular adenoma 29.4 TSHR TG NKX2-1 MET HGF CALCA
23 thyroid cancer, nonmedullary, 1 11.0
24 hypoparathyroidism 10.6
25 graves' disease 10.5
26 thyroid tumor 10.5
27 malignant struma ovarii 10.3 TG NKX2-1
28 iodine hypothyroidism 10.3 TSHR TG
29 thyroid gland mucoepidermoid carcinoma 10.3 TG CALCA
30 primary congenital hypothyroidism 10.3 TSHR NKX2-1
31 spindle epithelial tumor with thymus-like differentiation tumor 10.3 TG CALCA
32 thyroid crisis 10.3 TSHR TG
33 isthmus cancer 10.3 TG CALCA
34 toxic diffuse goiter 10.3 TSHR TG
35 substernal goiter 10.3 TG CALCA
36 atypical follicular adenoma 10.3 TG CALCA
37 thyroid sarcoma 10.3 TG CALCA
38 nonencapsulated sclerosing carcinoma 10.3 TG CALCA
39 acute thyroiditis 10.3 TG CALCA
40 body mass index quantitative trait locus 1 10.3
41 b-lymphoblastic leukemia/lymphoma 10.3
42 postsurgical hypothyroidism 10.3
43 pik3ca-related overgrowth syndrome 10.3
44 fetal adenoma 10.3 TG CALCA
45 subacute lymphocytic thyroiditis 10.3 TSHR TG
46 acneiform dermatitis 10.3 CRKL BRAF
47 larynx sarcoma 10.3 NKX2-1 EPCAM
48 epithelial malignant thymoma 10.3 TG CALCA
49 plummer's disease 10.2 TSHR TG
50 uterine corpus sarcoma 10.2 NKX2-1 CALCA

Graphical network of the top 20 diseases related to Papillary Thyroid Microcarcinoma:



Diseases related to Papillary Thyroid Microcarcinoma

Symptoms & Phenotypes for Papillary Thyroid Microcarcinoma

Clinical features from OMIM®:

603744 (Updated 05-Apr-2021)

MGI Mouse Phenotypes related to Papillary Thyroid Microcarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.06 BRAF EPCAM HGF IDO1 MET NKX2-1
2 growth/size/body region MP:0005378 9.96 BRAF CRKL EPCAM HGF MET NKX2-1
3 endocrine/exocrine gland MP:0005379 9.92 BRAF CRKL EPCAM MET NKX2-1 TG
4 digestive/alimentary MP:0005381 9.85 BRAF EPCAM MET NKX2-1 TG TP63
5 limbs/digits/tail MP:0005371 9.63 BRAF CRKL MET TG TP63 TSHR
6 neoplasm MP:0002006 9.5 BRAF CRKL MET NKX2-1 NQO1 TP63
7 no phenotypic analysis MP:0003012 9.1 EPCAM HGF MET MKI67 NKX2-1 TP63

Drugs & Therapeutics for Papillary Thyroid Microcarcinoma

Drugs for Papillary Thyroid Microcarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved 137-58-6 3676
2
Parathyroid hormone Approved, Investigational 9002-64-6
3
Ethanol Approved 64-17-5 702
4 Anesthetics
5 Anti-Infective Agents, Local
6 Anti-Infective Agents

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Prophylactic Central Lymph Node Dissection in Papillary Thyroid Microcarcinoma: A Prospective Randomized Controlled Trial Completed NCT00795782 Phase 3
2 Pilot Study to Evaluate the Safety and Efficacy of Percutaneous Laser Ablation of Thyroid Papillary Microcarcinoma Recruiting NCT04623801 Phase 2
3 Genetic Expression Alteration Affect on Lateral Neck Node Metastasis of Thyroid Papillary Microcarcinoma : Microarray Analysis Completed NCT01384669
4 Proper Extent of Surgery for Papillary Microcarcinoma Completed NCT01648569
5 Radiofrequency Ablation of Low Risk Papillary Thyroid Microcarcinoma: Safety and Efficacy Recruiting NCT03432299
6 A Multicenter, Randomized and Controlled Trial of Radiofrequency Ablation vs. Conventional Surgery as Treatment of Papillary Thyroid Microcarcinoma (PTMC) Recruiting NCT03808779
7 Active Surveillance of Papillary Thyroid Microcarcinoma Recruiting NCT02609685
8 Active Surveillance of Papillary Thyroid Microcarcinoma (PTMC) in Catholic Medical Center Recruiting NCT02952612
9 A Multicenter Prospective Controlled Trial of Laser Ablation Versus Surgery for the Treatment of Papillary Thyroid Microcarcinoma Recruiting NCT03377829
10 Active Surveillance on Papillary Thyroid Microcarcinoma Active, not recruiting NCT02938702
11 What is the Relation of Microbiome to Papillary Thyroid Microcarcinoma Development? Not yet recruiting NCT04376203
12 A Prospective Randomized Trial Comparing Ultrasound-guided High Intensity Focused Ultrasound (HIFU) Ablation With Active Surveillance (AS) in the Management of Low-risk Papillary Thyroid Microcarcinoma (PTMC) Suspended NCT03327636
13 Percutaneous Ethanol Injection for Primary Papillary Thyroid Microcarcinoma Terminated NCT01974284 percutaneous ethanol ablation

Search NIH Clinical Center for Papillary Thyroid Microcarcinoma

Genetic Tests for Papillary Thyroid Microcarcinoma

Genetic tests related to Papillary Thyroid Microcarcinoma:

# Genetic test Affiliating Genes
1 Papillary Thyroid Microcarcinoma 29

Anatomical Context for Papillary Thyroid Microcarcinoma

MalaCards organs/tissues related to Papillary Thyroid Microcarcinoma:

40
Thyroid, Lymph Node, Breast, Bone, Brain, Skeletal Muscle, Skin

Publications for Papillary Thyroid Microcarcinoma

Articles related to Papillary Thyroid Microcarcinoma:

(show top 50) (show all 758)
# Title Authors PMID Year
1
Familial papillary thyroid microcarcinoma: a new clinical entity. 57 61
10030330 1999
2
Papillary thyroid microcarcinoma: a study of 535 cases observed in a 50-year period. 57 61
1455316 1992
3
BRAF mutation in papillary thyroid microcarcinoma: the promise of better risk management. 54 61
19159982 2009
4
Solid cell nests in Hashimoto's thyroiditis sharing features with papillary thyroid microcarcinoma. 61 54
19809803 2009
5
Comparative evaluation of recombinant human thyrotropin-stimulated thyroglobulin levels, 131I whole-body scintigraphy, and neck ultrasonography in the follow-up of patients with papillary thyroid microcarcinoma who have not undergone radioiodine therapy. 61 54
16219716 2006
6
The BRAF mutation is not associated with poor prognostic factors in Korean patients with conventional papillary thyroid microcarcinoma. 54 61
16268813 2005
7
Recurrence-free survival after total thyroidectomy and lobectomy in patients with papillary thyroid microcarcinoma. 61
32651895 2021
8
Bilateral multifocality, a marker for aggressive disease, is not an independent prognostic factor for papillary thyroid microcarcinoma: A propensity score matching analysis. 61
33660317 2021
9
Protocol for a Korean Multicenter Prospective Cohort Study of Active Surveillance or Surgery (KoMPASS) in Papillary Thyroid Microcarcinoma. 61
33752303 2021
10
Position paper from the Japan Thyroid Association task force on the management of low-risk papillary thyroid microcarcinoma (T1aN0M0) in adults. 61
33762511 2021
11
Association between preoperative serum TSH and tumor status in patients with papillary thyroid microcarcinoma. 61
33755880 2021
12
Effect of Initial Treatment Choice on 2-year Quality of Life in Patients with Low-risk Papillary Thyroid Microcarcinoma. 61
33248442 2021
13
Interobserver Reproducibility in Sonographic Measurement of Diameter and Volume of Papillary Thyroid Microcarcinoma. 61
33287640 2021
14
The quality of life in papillary thyroid microcarcinoma patients undergoing lobectomy or total thyroidectomy: A cross-sectional study. 61
33638269 2021
15
[Clinical and ultrasonic features of papillary thyroid microcarcinoma and risk factors for central lymph node metastasis]. 61
33794614 2021
16
Enemy Beyond the Wall: Clinicopathological Features of Intrathyroidal Papillary Thyroid Carcinoma (T1-T3a) That Metastasize to Lymph Nodes Without Extrathyroidal Extension. 61
33650923 2021
17
Minimal extrathyroid extension in papillary micro carcinoma of the thyroid is an independent risk factor for relapse through lymph node and distant metastases. 61
33771902 2021
18
Five-year follow-up results of thermal ablation for low-risk papillary thyroid microcarcinomas: systematic review and meta-analysis. 61
33713168 2021
19
Which is preferred for initial treatment of papillary thyroid cancer, total thyroidectomy or lobotomy? 61
33512778 2021
20
Choosing optimal microcarcinoma patients for active surveillance study (COMPASS) - effectiveness evaluation of a pre-operative clinical framework. 61
33610810 2021
21
Management of sonographically suspicious thyroid nodules 1 cm or smaller and candidacy for active surveillance: Experience of a tertiary center in China. 61
33607263 2021
22
Long-term outcomes of radiofrequency ablation for unifocal low-risk papillary thyroid microcarcinoma: a large cohort study of 414 patients. 61
32813103 2021
23
Active Surveillance for Papillary Thyroid Microcarcinoma in a Population with Restrictive Diagnostic Workup Strategies. 61
33430696 2021
24
Does Multifocal Papillary Thyroid Microcarcinoma With a Total Tumor Diameter >1 cm Indicate Poor Biological Behavior? The Evidence is Insufficient. 61
33547013 2021
25
Marked Decrease Over Time in Conversion Surgery After Active Surveillance of Low-Risk Papillary Thyroid Microcarcinoma. 61
32664805 2021
26
Favorable outcomes of papillary thyroid microcarcinoma concurrent with Graves' disease after radioactive iodine therapy. 61
33551434 2021
27
Comparison of ultrasound guided percutaneous radiofrequency ablation and open thyroidectomy in the treatment of low-risk papillary thyroid microcarcinoma: A propensity score matching study. 61
33579830 2021
28
Indications and Strategy for Active Surveillance of Adult Low-Risk Papillary Thyroid Microcarcinoma: Consensus Statements from the Japan Association of Endocrine Surgery Task Force on Management for Papillary Thyroid Microcarcinoma. 61
33023426 2021
29
Multiple simple cystic metastases in the lateral neck at presentation with papillary thyroid microcarcinoma: A case report. 61
33530180 2021
30
Molecular characterisation and clinical correlation of papillary thyroid microcarcinoma. 61
32621051 2021
31
Letter to the Editor: "US-guided Microwave Ablation of Low-risk Papillary Thyroid Microcarcinoma: Longer-term Results of a Prospective Study". 61
33091130 2021
32
Clinician Be My Guide in Active Surveillance of Papillary Thyroid Microcarcinoma. 61
33237282 2021
33
Diagnostic value of routine ultrasonography combined with ultrasound elastography for papillary thyroid microcarcinoma: A protocol for systematic review and meta-analysis. 61
33530187 2021
34
Application of carbon nanoparticles combined with intraoperative neuromonitoring in papillary thyroid microcarcinoma surgery. 61
33137674 2021
35
YY1-induced up-regulation of FOXE1 is negatively regulated by miR-129-5p and contributes to the progression of papillary thyroid microcarcinoma. 61
33798911 2021
36
A Comparison of the Seventh and Eighth Editions of the AJCC Staging Systems to Predict Recurrence in Papillary Thyroid Microcarcinoma. 61
33521903 2021
37
First bilateral non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) co-occurring with bilateral papillary thyroid microcarcinoma. Case report and literature review. 61
33341424 2021
38
Clinical management of low-risk papillary thyroid microcarcinoma. 61
33435642 2021
39
Triggers of thyroid cancer diagnosis: a systematic review and meta-analysis. 61
33512656 2021
40
Case report and literature review: Horner syndrome subsequent to endoscopic thyroid surgery. 61
33441131 2021
41
Effect of optical energy modulation on the thermal response of biological tissue: computational and experimental validations. 61
33408969 2020
42
A shift to more targeted thyroidectomies increased the detection of thyroid cancer and in particular low-risk papillary tumors in Southwestern Greece the decade 2007 to 2016. 61
33364420 2020
43
The Ongoing Debate Regarding Completion Thyroidectomy Versus Primary Thyroid Surgery for Low and Intermediate Differentiated Thyroid Carcinoma: A Meta-Analysis. 61
33329985 2020
44
Clinical and pathologic predictors of lymph node metastasis in papillary thyroid microcarcinomas. 61
33126150 2020
45
Management of cN0 papillary thyroid microcarcinoma patients according to risk-scoring model for central lymph node metastasis and predictors of recurrence. 61
32557354 2020
46
[Current treatment strategies for papillary thyroid microcarcinoma]. 61
32776249 2020
47
Quality of Life in Patients with Low-Risk Papillary Thyroid Microcarcinoma: Active Surveillance Versus Immediate Surgery. 61
33471737 2020
48
Comparison of Outcomes Following Thyroid Isthmusectomy, Unilateral Thyroid Lobectomy, and Total Thyroidectomy in Patients with Papillary Thyroid Microcarcinoma of the Thyroid Isthmus: A Retrospective Study at a Single Center. 61
33351790 2020
49
Long-Term Follow-Up Results of Ultrasound-Guided Radiofrequency Ablation for Low-Risk Papillary Thyroid Microcarcinoma: More Than 5-Year Follow-Up for 84 Tumors. 61
32375570 2020
50
Effects of Microwave Ablation on Papillary Thyroid Microcarcinoma: A Five-Year Follow-Up Report. 61
32458748 2020

Variations for Papillary Thyroid Microcarcinoma

Expression for Papillary Thyroid Microcarcinoma

Search GEO for disease gene expression data for Papillary Thyroid Microcarcinoma.

Pathways for Papillary Thyroid Microcarcinoma

Pathways related to Papillary Thyroid Microcarcinoma according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1 12.46 MET HGF CRKL BRAF
2
Show member pathways
12.44 NQO1 MET HGF BRAF
3
Show member pathways
12.4 MET HGF CRKL BRAF
4 12.38 NQO1 MET HGF CRKL BRAF
5
Show member pathways
12.36 MET HGF CRKL BRAF
6
Show member pathways
12.18 MET HGF CRKL BRAF
7 11.7 TP63 MET HGF
8 11.05 TP63 MET HGF EPCAM
9 10.99 MET HGF
10 10.66 TSHR MET HGF
11 10.6 MET HGF
12 9.93 TSHR TG

GO Terms for Papillary Thyroid Microcarcinoma

Biological processes related to Papillary Thyroid Microcarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 aging GO:0007568 9.63 TP63 NQO1 CALCA
2 establishment of skin barrier GO:0061436 9.43 TP63 MET
3 pattern specification process GO:0007389 9.43 TP63 NKX2-1 CRKL
4 anatomical structure formation involved in morphogenesis GO:0048646 9.4 TP63 NKX2-1
5 hepatocyte growth factor receptor signaling pathway GO:0048012 9.37 MET HGF
6 cranial skeletal system development GO:1904888 9.32 TP63 CRKL
7 animal organ morphogenesis GO:0009887 9.26 TP63 NKX2-1 CRKL BRAF
8 negative regulation of hydrogen peroxide-mediated programmed cell death GO:1901299 9.16 MET HGF
9 thyroid gland development GO:0030878 8.8 TG NKX2-1 BRAF

Molecular functions related to Papillary Thyroid Microcarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex binding GO:0044877 9.35 TSHR HGF EPCAM CALCA BRAF
2 identical protein binding GO:0042802 9.23 TP63 TG NQO1 MET HGF CRKL

Sources for Papillary Thyroid Microcarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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