MCID: PPL035
MIFTS: 43

Papillary Thyroid Microcarcinoma

Categories: Cancer diseases

Aliases & Classifications for Papillary Thyroid Microcarcinoma

MalaCards integrated aliases for Papillary Thyroid Microcarcinoma:

Name: Papillary Thyroid Microcarcinoma 57 29 55 73

Classifications:



External Ids:

OMIM 57 603744
MedGen 42 C1709457
UMLS 73 C1709457

Summaries for Papillary Thyroid Microcarcinoma

MalaCards based summary : Papillary Thyroid Microcarcinoma is related to thyroiditis and postsurgical hypothyroidism. An important gene associated with Papillary Thyroid Microcarcinoma is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways/superpathways are MAPK signaling pathway and Gastric cancer. The drugs Ethanol and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lymph node and bone, and related phenotypes are cellular and cardiovascular system

Description from OMIM: 603744

Related Diseases for Papillary Thyroid Microcarcinoma

Diseases related to Papillary Thyroid Microcarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 thyroiditis 30.8 CALCA TG TSHR
2 postsurgical hypothyroidism 30.5 TG TSHR
3 ovarian germ cell teratoma 30.5 NKX2-1 TG
4 goiter 30.4 CALCA NKX2-1 TG TSHR
5 endemic goiter 30.3 TG TSHR
6 hypothyroidism 30.3 CALCA NKX2-1 TG TSHR
7 struma ovarii 30.1 BRAF NKX2-1 TG TSHR
8 anaplastic thyroid cancer 30.1 BRAF MET NKX2-1 TG
9 thyroid cancer 30.0 BRAF CALCA MET NKX2-1 TG TSHR
10 thyroid cancer, nonmedullary, 1 10.3
11 mucoepidermoid thyroid carcinoma 10.3 CALCA TG
12 colloid adenoma 10.2 NKX2-1 TG
13 suppurative thyroiditis 10.2 CALCA TG
14 ovarian germ cell cancer 10.2 NKX2-1 TG
15 thyroid sarcoma 10.2 CALCA TG
16 atypical follicular adenoma 10.2 CALCA TG
17 body mass index quantitative trait locus 1 10.2
18 graves' disease 10.2
19 malignant struma ovarii 10.2 NKX2-1 TG
20 acute thyroiditis 10.2 CALCA TG
21 mature teratoma 10.2 BRAF TG
22 lymphoepithelioma-like thymic carcinoma 10.2 EPCAM TG
23 hypoadrenalism 10.2 CALCA TG
24 benign struma ovarii 10.2 TG TSHR
25 amyloid tumor 10.2 CALCA TG
26 neonatal hypothyroidism 10.2 TG TSHR
27 fetal adenoma 10.2 CALCA NKX2-1 TG
28 ovarian cystic teratoma 10.2 CALCA NKX2-1 TG
29 hemangioma of lung 10.1 NKX2-1 TP63
30 thyroid carcinoma, familial medullary 10.1 CALCA NKX2-1 TG
31 acral lentiginous melanoma 10.1 BRAF MET
32 childhood hepatocellular carcinoma 10.1 EPCAM MET
33 deafness, autosomal recessive 39 10.1 HGF MET
34 endocrine gland cancer 10.1 CALCA EPCAM TG
35 graves disease 1 10.1 TG TSHR
36 deafness, autosomal recessive 97 10.1 HGF MET
37 myxedema 10.1 TG TSHR
38 athyreosis 10.1 NKX2-1 TG TSHR
39 epispadias 10.1 CALCA TP63
40 hypothyroidism, congenital, nongoitrous, 2 10.1 NKX2-1 TG TSHR
41 endometrial squamous cell carcinoma 10.1 HGF MET
42 toxic diffuse goiter 10.1 TG TSHR
43 nodular goiter 10.1 CALCA TG TSHR
44 large cell medulloblastoma 10.1 HGF MET
45 nontoxic goiter 10.1 CALCA TG TSHR
46 subacute thyroiditis 10.1 TG TSHR
47 congenital hypothyroidism 10.1 NKX2-1 TG TSHR
48 thyroid hormone resistance, generalized, autosomal dominant 10.1
49 adrenocortical carcinoma, hereditary 10.1
50 lymphoma 10.1

Graphical network of the top 20 diseases related to Papillary Thyroid Microcarcinoma:



Diseases related to Papillary Thyroid Microcarcinoma

Symptoms & Phenotypes for Papillary Thyroid Microcarcinoma

Clinical features from OMIM:

603744

MGI Mouse Phenotypes related to Papillary Thyroid Microcarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.11 BRAF EPCAM HGF IDO1 MET NKX2-1
2 cardiovascular system MP:0005385 10.08 BRAF CRKL EPCAM HGF IDO1 MET
3 growth/size/body region MP:0005378 10.07 BRAF CRKL EPCAM HGF MET NKX2-1
4 endocrine/exocrine gland MP:0005379 10.01 BRAF CRKL EPCAM MET NKX2-1 TG
5 hematopoietic system MP:0005397 9.92 BRAF CRKL EPCAM HGF IDO1 NQO1
6 digestive/alimentary MP:0005381 9.91 BRAF EPCAM MET NKX2-1 TG TP63
7 immune system MP:0005387 9.91 BRAF CRKL EPCAM IDO1 MET NQO1
8 limbs/digits/tail MP:0005371 9.63 BRAF CRKL MET TG TP63 TSHR
9 neoplasm MP:0002006 9.5 BRAF CRKL MET NKX2-1 NQO1 TP63
10 no phenotypic analysis MP:0003012 9.1 EPCAM HGF MET MKI67 NKX2-1 TP63

Drugs & Therapeutics for Papillary Thyroid Microcarcinoma

Drugs for Papillary Thyroid Microcarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Not Applicable 64-17-5 702
2
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
3 Central Nervous System Depressants Not Applicable
4 Anti-Infective Agents Not Applicable
5 Anti-Infective Agents, Local Not Applicable
6 Anesthetics Not Applicable
7 Complement System Proteins Not Applicable

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Prophylactic Central Lymph Node Dissection in Papillary Thyroid Microcarcinoma Completed NCT00795782 Phase 3
2 Extent of Central Lymph Node Dissection in Papillary Thyroid Microcarcinoma Recruiting NCT01149161 Phase 2, Phase 3
3 Percutaneous Ethanol Injection for Primary Papillary Thyroid Microcarcinoma Unknown status NCT01974284 Not Applicable percutaneous ethanol ablation
4 Genetic Expression Alteration Affect on Lateral Neck Node Metastasis of Thyroid Papillary Microcarcinoma : Microarray Analysis Unknown status NCT01384669
5 Active Surveillance of Papillary Thyroid Microcarcinoma Recruiting NCT02609685 Not Applicable
6 A Multicenter Trial of Radiofrequency Ablation vs. Surgery as Treatment of Papillary Thyroid Microcarcinoma. Recruiting NCT03808779 Not Applicable
7 Radiofrequency Ablation of Low Risk Papillary Thyroid Microcarcinoma Not yet recruiting NCT03432299 Not Applicable
8 A Trial Comparing USG-HIFU vs AS in Management of Low-risk PTMC Suspended NCT03327636 Not Applicable
9 Active Surveillance of Papillary Thyroid Microcarcinoma Recruiting NCT02952612
10 Long-term Outcomes of Total Thyroidectomy Versus Less Than Total Thyroidectomy for Papillary Thyroid Microcarcinoma Completed NCT01648569
11 Active Surveillance on Papillary Thyroid Microcarcinoma Recruiting NCT02938702
12 A Multicenter Trial of PLA vs. Surgery for Treating PTMC Recruiting NCT03377829 Not Applicable
13 Evaluation of Central Compartment Dissection Without Thyroidectomy Recruiting NCT03454464 Not Applicable
14 Application of Ultrasonic Gray-scale Ratio in Differentiating Benign From Malignant Thyroid Nodules. Not yet recruiting NCT03700762
15 Targeted-sequencing of PTC in Different Stages Not yet recruiting NCT03214978

Search NIH Clinical Center for Papillary Thyroid Microcarcinoma

Genetic Tests for Papillary Thyroid Microcarcinoma

Genetic tests related to Papillary Thyroid Microcarcinoma:

# Genetic test Affiliating Genes
1 Papillary Thyroid Microcarcinoma 29

Anatomical Context for Papillary Thyroid Microcarcinoma

MalaCards organs/tissues related to Papillary Thyroid Microcarcinoma:

41
Thyroid, Lymph Node, Bone, Skin, Lung, T Cells, Breast

Publications for Papillary Thyroid Microcarcinoma

Articles related to Papillary Thyroid Microcarcinoma:

(show top 50) (show all 367)
# Title Authors Year
1
The BRAFV600E mutation in papillary thyroid microcarcinoma with intermediate-risk to high-risk features: does the mutation have an effect on clinical response to radioiodine therapy? ( 30312216 )
2019
2
Interstitial fibrosis in papillary thyroid microcarcinoma and its association with biological behavior. ( 29552130 )
2018
3
Diagnostic value of ultrasound features and sex of fetuses in female patients with papillary thyroid microcarcinoma. ( 29760433 )
2018
4
Clinical predictors of lymph node metastasis and survival rate in papillary thyroid microcarcinoma: analysis of 3607 patients at a single institution. ( 29229118 )
2018
5
Impact of major different variants of papillary thyroid microcarcinoma on the clinicopathological characteristics: the study of 1041 cases. ( 28744725 )
2018
6
The role of diagnostic <sup>131</sup>I-SPECT/TC in patients with papillary thyroid microcarcinoma in long-term follow-up. ( 29496990 )
2018
7
The anteroposterior diameter of nodules in the risk assessment of papillary thyroid microcarcinoma. ( 29517693 )
2018
8
Is advocacy for active surveillance over definitive intervention in papillary thyroid microcarcinoma applicable to European patients? ( 29770318 )
2018
9
Sonographic features of papillary thyroid microcarcinoma predicting high-volume central neck lymph node metastasis. ( 29937168 )
2018
10
Long-term efficacy of ultrasound-guided low power microwave ablation for the treatment of primary papillary thyroid microcarcinoma: a 3-year follow-up study. ( 29427209 )
2018
11
Multifocality is associated with central neck lymph node metastases in papillary thyroid microcarcinoma. ( 29942154 )
2018
12
CORRIGENDUM FOR &amp;quot;High Serum TSH Level Is Associated With Progression of Papillary Thyroid Microcarcinoma During Active Surveillance&amp;quot;. ( 29538759 )
2018
13
Ultrasonography is valuable in evaluation of papillary thyroid microcarcinoma based on 5 mm tumor size. ( 29970683 )
2018
14
Ultrasound-guided percutaneous microwave ablation versus surgery for papillary thyroid microcarcinoma. ( 29637797 )
2018
15
A favorable tumor size to define papillary thyroid microcarcinoma: an analysis of 1176 consecutive cases. ( 29740219 )
2018
16
Nomogram for predicting central lymph node metastasis in papillary thyroid microcarcinoma: A retrospective cohort study of 8668 patients. ( 29803769 )
2018
17
Clinical-pathological Characteristics and Prognostic Factors for Papillary Thyroid Microcarcinoma in the Elderly. ( 29344271 )
2018
18
Clinical analysis of cervical lymph node metastasis risk factors in patients with papillary thyroid microcarcinoma. ( 29876836 )
2018
19
A retrospective study of the clinical features in papillary thyroid microcarcinoma depending on age. ( 29762261 )
2018
20
Papillary thyroid microcarcinoma: characteristics at presentation, and evaluation of clinical and histological features associated with a worse prognosis in a Latin American cohort. ( 29694628 )
2018
21
Active Surveillance of Papillary Thyroid Microcarcinoma: A Mini-Review from Korea (Endocrinol Metab 2017;32:399-406, Tae Yong Kim et al.). ( 29589395 )
2018
22
Improved outcomes for papillary thyroid microcarcinoma care: active surveillance and case volume. ( 29977496 )
2018
23
High Serum TSH Level Is Associated With Progression of Papillary Thyroid Microcarcinoma During Active Surveillance. ( 29211863 )
2018
24
Patients' experiences of diagnosis and management of papillary thyroid microcarcinoma: a qualitative study. ( 29499654 )
2018
25
Percutaneous Laser Ablation of Unifocal Papillary Thyroid Microcarcinoma: Utility of Conventional Ultrasound and Contrast-Enhanced Ultrasound in Assessing Local Therapeutic Response. ( 29488064 )
2018
26
Papillary thyroid microcarcinoma in super obese patient. ( 29923487 )
2018
27
Study Protocol of Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma (MAeSTro). ( 29947183 )
2018
28
Prophylactic central neck dissection and local recurrence in papillary thyroid microcarcinoma: a meta-analysis. ( 30017872 )
2018
29
Papillary thyroid microcarcinoma (Black Ink). ( 30018751 )
2018
30
Is biopsy enough for papillary thyroid microcarcinoma?: An analysis of the SEER database 2004 to 2013 with propensity score matching. ( 30075609 )
2018
31
Predictive factors of lateral lymph node metastasis in solitary papillary thyroid microcarcinoma without gross extrathyroidal extension. ( 30078501 )
2018
32
Corrigendum: Author's Name Correction. Study Protocol of Multicenter Prospective Cohort Study of Active Surveillance on Papillary Thyroid Microcarcinoma (MAeSTro). ( 30112870 )
2018
33
Treatment efficacy between total thyroidectomy and lobectomy for patients with papillary thyroid microcarcinoma: A systemic review and meta-analysis. ( 30158063 )
2018
34
Author Correction: Diagnostic value of ultrasound features and sex of fetuses in female patients with papillary thyroid microcarcinoma. ( 30177762 )
2018
35
Ultrasonographic features associated with false-negative and false-positive results of extrathyroidal extensions in papillary thyroid microcarcinoma. ( 30178419 )
2018
36
Papillary Thyroid Microcarcinoma: Reclassification to Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP): a Retrospective Clinicopathologic Study. ( 30196478 )
2018
37
Long-term oncologic outcomes of papillary thyroid microcarcinoma according to the presence of clinically apparent lymph node metastasis: a large retrospective analysis of 5,348 patients. ( 30214283 )
2018
38
Active Surveillance of Low-Risk Papillary Thyroid Microcarcinoma: A Multi-Center Cohort Study in Korea. ( 30226447 )
2018
39
Prediction of central lymph node metastasis in papillary thyroid microcarcinoma according to clinicopathologic factors and thyroid nodule sonographic features: a case-control study. ( 30233240 )
2018
40
The learning curve of endoscopic thyroid surgery for papillary thyroid microcarcinoma: CUSUM analysis of a single surgeon's experience. ( 30264276 )
2018
41
RISK FACTORS FOR CENTRAL LYMPH NODE METASTASES IN PATIENTS WITH PAPILLARY THYROID MICROCARCINOMA. ( 30289307 )
2018
42
Comparison of outcomes between hemithyroidectomy alone and hemithyroidectomy with elective unilateral central neck dissection in patients with papillary thyroid microcarcinoma. ( 30302890 )
2018
43
Comparison of the prevalence of incidental and non-incidental papillary thyroid microcarcinoma during 2008-2016: a single-center experience. ( 30305094 )
2018
44
Predictors for central lymph node metastases in CN0 papillary thyroid microcarcinoma (mPTC): A retrospect analysis of 1304 cases. ( 30348606 )
2018
45
Predictive Factors of Lateral Lymph Node Metastasis in Papillary Thyroid Microcarcinoma. ( 30361912 )
2018
46
Comparison of endoscopic thyroidectomy via a modified axillo-breast approach with the conventional breast approach for treatment of unilateral papillary thyroid microcarcinoma. ( 30407297 )
2018
47
Natural history of papillary thyroid microcarcinoma: Kinetic analyses on tumor volume during active surveillance and before presentation. ( 30413323 )
2018
48
Unusual presentation of recurrent papillary thyroid microcarcinoma with neck muscles and skin dissemination. ( 30415409 )
2018
49
Retrospective analysis of prognostic factors in patients of papillary thyroid microcarcinoma. ( 30473750 )
2018
50
Correction to: Unusual presentation of recurrent papillary thyroid microcarcinoma with neck muscles and skin dissemination. ( 30515667 )
2018

Variations for Papillary Thyroid Microcarcinoma

Expression for Papillary Thyroid Microcarcinoma

Search GEO for disease gene expression data for Papillary Thyroid Microcarcinoma.

Pathways for Papillary Thyroid Microcarcinoma

Pathways related to Papillary Thyroid Microcarcinoma according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1 12.46 BRAF CRKL HGF MET
2
Show member pathways
12.44 BRAF HGF MET NQO1
3
Show member pathways
12.4 BRAF CRKL HGF MET
4 12.38 BRAF CRKL HGF MET NQO1
5
Show member pathways
12.36 BRAF CRKL HGF MET
6
Show member pathways
12.07 BRAF CRKL HGF MET
7 11.7 HGF MET TP63
8 11.05 EPCAM HGF MET TP63
9 10.99 HGF MET
10 10.66 HGF MET TSHR
11 10.6 HGF MET
12 9.93 TG TSHR

GO Terms for Papillary Thyroid Microcarcinoma

Biological processes related to Papillary Thyroid Microcarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.67 HGF MET MKI67 TP63
2 aging GO:0007568 9.65 CALCA NQO1 TP63
3 peptidyl-tyrosine phosphorylation GO:0018108 9.63 BRAF HGF MET
4 anatomical structure formation involved in morphogenesis GO:0048646 9.43 NKX2-1 TP63
5 pattern specification process GO:0007389 9.43 CRKL NKX2-1 TP63
6 establishment of skin barrier GO:0061436 9.4 MET TP63
7 hepatocyte growth factor receptor signaling pathway GO:0048012 9.32 HGF MET
8 animal organ morphogenesis GO:0009887 9.26 BRAF CRKL NKX2-1 TP63
9 negative regulation of hydrogen peroxide-mediated programmed cell death GO:1901299 9.16 HGF MET
10 thyroid gland development GO:0030878 8.8 BRAF NKX2-1 TG

Molecular functions related to Papillary Thyroid Microcarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.17 BRAF CALCA CRKL HGF MET NQO1
2 protein tyrosine kinase activity GO:0004713 9.13 BRAF HGF MET

Sources for Papillary Thyroid Microcarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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