MCID: PPL035
MIFTS: 39

Papillary Thyroid Microcarcinoma

Categories: Cancer diseases

Aliases & Classifications for Papillary Thyroid Microcarcinoma

MalaCards integrated aliases for Papillary Thyroid Microcarcinoma:

Name: Papillary Thyroid Microcarcinoma 56 29 54 71

Classifications:



External Ids:

OMIM 56 603744
MedGen 41 C1709457
UMLS 71 C1709457

Summaries for Papillary Thyroid Microcarcinoma

MalaCards based summary : Papillary Thyroid Microcarcinoma is related to thyroid carcinoma and goiter. An important gene associated with Papillary Thyroid Microcarcinoma is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways/superpathways are MAPK signaling pathway and Gastric cancer. The drugs Lidocaine and Parathyroid hormone have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lymph node and breast, and related phenotypes are cellular and cardiovascular system

More information from OMIM: 603744

Related Diseases for Papillary Thyroid Microcarcinoma

Diseases related to Papillary Thyroid Microcarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 thyroid carcinoma 31.4 TSHR TG NKX2-1 CALCA BRAF
2 goiter 30.9 TSHR TG NKX2-1 CALCA
3 thyroiditis 30.9 TSHR TG NKX2-1 CALCA BRAF
4 hashimoto thyroiditis 30.8 TSHR TG CALCA BRAF
5 ovarian germ cell teratoma 30.7 TG NKX2-1
6 hyperthyroidism 30.7 TSHR TG CALCA
7 thyroid lymphoma 30.7 TG CALCA
8 ovarian germ cell cancer 30.6 TG NKX2-1
9 thyroid carcinoma, familial medullary 30.6 TG NKX2-1 CALCA BRAF
10 thyroid gland disease 30.6 TSHR TG NKX2-1 CALCA
11 hypothyroidism 30.5 TSHR TG NKX2-1 CALCA BRAF
12 endemic goiter 30.5 TSHR TG CALCA
13 multinodular goiter 30.4 TSHR TG NKX2-1 CALCA
14 plummer's disease 30.4 TSHR TG
15 nodular goiter 30.3 TSHR TG HGF CALCA BRAF
16 struma ovarii 30.2 TSHR TG NKX2-1 BRAF
17 differentiated thyroid carcinoma 30.1 TSHR TG NKX2-1 MET BRAF
18 thyroid cancer, nonmedullary, 2 30.0 TSHR TG CALCA BRAF
19 adenoma 29.9 TSHR TG MKI67 BRAF
20 papillary carcinoma 29.7 TSHR TG NKX2-1 MET HGF CALCA
21 squamous cell carcinoma 29.5 TP63 MKI67 EPCAM BRAF
22 follicular adenoma 29.4 TSHR TG NKX2-1 MET CALCA BRAF
23 thyroid gland anaplastic carcinoma 29.2 TSHR TG NKX2-1 MET CALCA BRAF
24 thyroid cancer, nonmedullary, 1 11.1
25 hypoparathyroidism 10.6
26 graves' disease 10.5
27 thyroid tumor 10.5
28 thyroid gland mucoepidermoid carcinoma 10.4 TG CALCA
29 malignant struma ovarii 10.4 TG NKX2-1
30 spindle epithelial tumor with thymus-like differentiation tumor 10.4 TG CALCA
31 atypical follicular adenoma 10.4 TG CALCA
32 substernal goiter 10.4 TG CALCA
33 thyroid sarcoma 10.4 TG CALCA
34 isthmus cancer 10.4 TG CALCA
35 fetal adenoma 10.4 TG CALCA
36 nonencapsulated sclerosing carcinoma 10.4 TG CALCA
37 acute thyroiditis 10.4 TG CALCA
38 respiratory distress syndrome in premature infants 10.4 NKX2-1 BRAF
39 ureter small cell carcinoma 10.4 NKX2-1 CALCA
40 larynx sarcoma 10.4 NKX2-1 EPCAM
41 epithelial malignant thymoma 10.4 TG CALCA
42 dendritic cell thymoma 10.4 TG CALCA
43 colon neuroendocrine neoplasm 10.4 NKX2-1 CALCA
44 body mass index quantitative trait locus 1 10.3
45 postsurgical hypothyroidism 10.3
46 thyroid gland medullary carcinoma 10.3
47 peritoneal serous adenocarcinoma 10.3 NKX2-1 EPCAM
48 sclerosing hemangioma 10.3 NKX2-1 CALCA
49 carotid body cancer 10.3 TG NKX2-1 CALCA
50 ectopic thymus 10.3 TG NKX2-1 CALCA

Graphical network of the top 20 diseases related to Papillary Thyroid Microcarcinoma:



Diseases related to Papillary Thyroid Microcarcinoma

Symptoms & Phenotypes for Papillary Thyroid Microcarcinoma

Clinical features from OMIM:

603744

MGI Mouse Phenotypes related to Papillary Thyroid Microcarcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.06 BRAF EPCAM HGF IDO1 MET NKX2-1
2 cardiovascular system MP:0005385 10.03 BRAF CRKL EPCAM HGF IDO1 MET
3 growth/size/body region MP:0005378 9.96 BRAF CRKL EPCAM HGF MET NKX2-1
4 endocrine/exocrine gland MP:0005379 9.92 BRAF CRKL EPCAM MET NKX2-1 TG
5 digestive/alimentary MP:0005381 9.85 BRAF EPCAM MET NKX2-1 TG TP63
6 limbs/digits/tail MP:0005371 9.63 BRAF CRKL MET TG TP63 TSHR
7 neoplasm MP:0002006 9.5 BRAF CRKL MET NKX2-1 NQO1 TP63
8 no phenotypic analysis MP:0003012 9.1 EPCAM HGF MET MKI67 NKX2-1 TP63

Drugs & Therapeutics for Papillary Thyroid Microcarcinoma

Drugs for Papillary Thyroid Microcarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved 137-58-6 3676
2
Parathyroid hormone Approved, Investigational 9002-64-6
3
Ethanol Approved 64-17-5 702
4 Complement System Proteins
5 Anesthetics
6 Anti-Infective Agents, Local
7 Anti-Infective Agents

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Prophylactic Central Lymph Node Dissection in Papillary Thyroid Microcarcinoma: A Prospective Randomized Controlled Trial Completed NCT00795782 Phase 3
2 Predictive Factors of Lymph Node Metastasis in Patients With Papillary Microcarcinoma of the Thyroid Completed NCT04274829
3 Genetic Expression Alteration Affect on Lateral Neck Node Metastasis of Thyroid Papillary Microcarcinoma : Microarray Analysis Completed NCT01384669
4 Proper Extent of Surgery for Papillary Microcarcinoma Completed NCT01648569
5 Radiofrequency Ablation of Low Risk Papillary Thyroid Microcarcinoma: Safety and Efficacy Recruiting NCT03432299
6 Active Surveillance of Papillary Thyroid Microcarcinoma (PTMC) in Catholic Medical Center Recruiting NCT02952612
7 Prospective Active Surveillance Versus Surgery in Thyroid Papillary Microcarcinoma Recruiting NCT04129281
8 Active Surveillance of Papillary Thyroid Microcarcinoma Recruiting NCT02609685
9 To Evaluate the Practicable, Thoroughness and Clinical Value of Bilateral Central Compartment Dissection While Preserve Contrary Thyroid Glands Recruiting NCT03454464
10 A Multicenter, Randomized and Controlled Trial of Radiofrequency Ablation vs. Conventional Surgery as Treatment of Papillary Thyroid Microcarcinoma (PTMC) Recruiting NCT03808779
11 A Multicenter Prospective Controlled Trial of Laser Ablation Versus Surgery for the Treatment of Papillary Thyroid Microcarcinoma Recruiting NCT03377829
12 Study on the Application of Convenient Foot-control Exhaust Method in Endoscopic Thyroidectomy Recruiting NCT03411187
13 Active Surveillance on Papillary Thyroid Microcarcinoma Active, not recruiting NCT02938702
14 What is the Relation of Microbiome to Papillary Thyroid Microcarcinoma Development? Not yet recruiting NCT04376203
15 Application of Ultrasonic Gray-scale Ratio in Differentiating Benign From Malignant Thyroid Nodules. Not yet recruiting NCT03700762
16 A Prospective Randomized Trial Comparing Ultrasound-guided High Intensity Focused Ultrasound (HIFU) Ablation With Active Surveillance (AS) in the Management of Low-risk Papillary Thyroid Microcarcinoma (PTMC) Suspended NCT03327636
17 Percutaneous Ethanol Injection for Primary Papillary Thyroid Microcarcinoma Terminated NCT01974284 percutaneous ethanol ablation

Search NIH Clinical Center for Papillary Thyroid Microcarcinoma

Genetic Tests for Papillary Thyroid Microcarcinoma

Genetic tests related to Papillary Thyroid Microcarcinoma:

# Genetic test Affiliating Genes
1 Papillary Thyroid Microcarcinoma 29

Anatomical Context for Papillary Thyroid Microcarcinoma

MalaCards organs/tissues related to Papillary Thyroid Microcarcinoma:

40
Thyroid, Lymph Node, Breast, Bone, Brain, Lung, Skin

Publications for Papillary Thyroid Microcarcinoma

Articles related to Papillary Thyroid Microcarcinoma:

(show top 50) (show all 674)
# Title Authors PMID Year
1
Familial papillary thyroid microcarcinoma: a new clinical entity. 56 61
10030330 1999
2
Papillary thyroid microcarcinoma: a study of 535 cases observed in a 50-year period. 56 61
1455316 1992
3
BRAF mutation in papillary thyroid microcarcinoma: the promise of better risk management. 54 61
19159982 2009
4
Solid cell nests in Hashimoto's thyroiditis sharing features with papillary thyroid microcarcinoma. 54 61
19809803 2009
5
Comparative evaluation of recombinant human thyrotropin-stimulated thyroglobulin levels, 131I whole-body scintigraphy, and neck ultrasonography in the follow-up of patients with papillary thyroid microcarcinoma who have not undergone radioiodine therapy. 61 54
16219716 2006
6
The BRAF mutation is not associated with poor prognostic factors in Korean patients with conventional papillary thyroid microcarcinoma. 54 61
16268813 2005
7
Predicting factors for central or lateral lymph node metastasis in conventional papillary thyroid microcarcinoma. 61
31818425 2020
8
Management of cN0 papillary thyroid microcarcinoma patients according to risk-scoring model for central lymph node metastasis and predictors of recurrence. 61
32557354 2020
9
Clinicopathologic factors and preoperative ultrasonographic characteristics for predicting central lymph node metastasis in papillary thyroid microcarcinoma: a single center retrospective study. 61
32571753 2020
10
The metastasis rate and high-risk factors for ipsilateral lateral neck lymph node metastasis in patients with papillary thyroid microcarcinoma (cT1aN0). 61
32532680 2020
11
Long-Term Follow-Up Results of Ultrasound-Guided Radiofrequency Ablation for Low-Risk Papillary Thyroid Microcarcinoma: More Than 5-Year Follow-Up for 84 Tumors. 61
32375570 2020
12
US-guided Microwave Ablation of Low-Risk Papillary Thyroid Microcarcinoma: Longer-Term Results of a Prospective Study. 61
32198508 2020
13
"A Prospective Mixed-Methods Study of Decision-Making on Surgery or Active Surveillance for Low-Risk Papillary Thyroid Cancer" by Sawka AM et al. (Thyroid 2020 Apr 8. doi: 10.1089/thy.2019.0592. Online ahead of print). 61
32484054 2020
14
Risk factors of metastatic lymph nodes in papillary thyroid microcarcinoma. Comment on patients selection for the study. 61
32456780 2020
15
What clinical and histological factors should advise the completion of thyroidectomy in patients with papillary thyroid microcarcinoma initially treated with a lobectomy? 61
31623820 2020
16
Efficacy and Safety of Thermal Ablation Techniques for the Treatment of Primary Papillary Thyroid Microcarcinoma: A Systematic Review and Meta-Analysis. 61
31801432 2020
17
Genomic and Transcriptomic Characteristics According to Size of Papillary Thyroid Microcarcinoma. 61
32466217 2020
18
Incidental versus clinical diagnosis of papillary thyroid microcarcinoma. Long-term prognosis. 61
31882257 2020
19
Patients' View on the Management of Papillary Thyroid Microcarcinoma: Active Surveillance or Surgery. 61
31910100 2020
20
Low-risk papillary thyroid microcarcinoma: Optimal management toward a more conservative approach. 61
32189352 2020
21
Effects of MWA on Papillary Thyroid Microcarcinoma: A 5-Year Follow-up Report. 61
32458748 2020
22
Papillary thyroid microcarcinoma: not always indolent. 61
32416927 2020
23
Papillary thyroid microcarcinoma presenting as a metastasis to the brain. 61
32233872 2020
24
Trends in nonoperative management of papillary thyroid microcarcinoma. 61
32189361 2020
25
[Significance of micropapillary histopathological subtype of thyroid carcinoma]. 61
32392929 2020
26
Total tumor diameter: the neglected value in papillary thyroid microcarcinoma. 61
31749082 2020
27
Recurrence following hemithyroidectomy in patients with low- and intermediate-risk papillary thyroid carcinoma. 61
32026467 2020
28
Routine Chest Computed Tomography at Presentation Does Not Identify Distant Metastasis in cT1aN0 Papillary Thyroid Carcinoma. 61
32368954 2020
29
Clinicopathologic characteristics and outcomes of papillary thyroid carcinoma in younger patients. 61
32282744 2020
30
Predicting the factors associated with central lymph node metastasis in clinical node-negative (cN0) papillary thyroid microcarcinoma. 61
31932880 2020
31
Left Supraclavicular Lymph Node Metastasis from Ovarian Cancer Associated with Papillary Thyroid Microcarcinoma, a Confusing Pathology-Essential Role of Functional Imaging. 61
32365823 2020
32
Wolf in Sheep's Clothing: Papillary Thyroid Microcarcinoma in the US. 61
32220437 2020
33
Risk Factors of Metastatic Lymph Nodes in Papillary Thyroid Microcarcinoma. 61
31980154 2020
34
Predictive factors for central lymph node metastases in papillary thyroid microcarcinoma. 61
32368529 2020
35
Impact of prophylactic unilateral central neck dissection needed for patients with papillary thyroid microcarcinoma. 61
32420259 2020
36
A comparison between unifocal papillary thyroid microcarcinoma with noninvasive follicular thyroid neoplasm with papillary-like nuclear features and other patterns: A retrospective clinicopathological study. 61
32317513 2020
37
Comparison of Lobectomy and Total Thyroidectomy in Unilateral Papillary Thyroid Microcarcinoma Patients with Ipsilateral Lateral Lymph Node Metastasis Without Gross Extrathyroidal Extension. 61
32328782 2020
38
Erratum: US-Guided Radiofrequency Ablation for Low-Risk Papillary Thyroid Microcarcinoma: Efficacy and Safety in a Large Population. 61
32193898 2020
39
Unusual case of radioactive iodine induced Graves disease with orbitopathy following total thyroidectomy in a patient with papillary thyroid microcarcinoma. 61
32293702 2020
40
Quality of Life in Patients with Papillary Thyroid Microcarcinoma According to Treatment: Total Thyroidectomy with or without Radioactive Iodine Ablation. 61
32207271 2020
41
Ultrasound-Guided Laser Ablation Versus Microwave Ablation for Patients With Unifocal Papillary Thyroid Microcarcinoma: A Retrospective Study. 61
32216112 2020
42
Papillary thyroid microcarcinoma with minimal extrathyroidal extension. Has it so indolent course to require a less aggressive treatment? 61
32216965 2020
43
Ultrasound-Guided Radiofrequency Ablation Versus Surgery for Low-Risk Papillary Thyroid Microcarcinoma: Results of Over 5 Years' Follow-Up. 61
31910107 2020
44
The contributing factors for lateral neck lymph node metastasis in papillary thyroid microcarcinoma (PTMC). 61
32146654 2020
45
Development and validation of a nomogram for preoperative prediction of cervical lymph node involvement in thyroid microcarcinoma. 61
32170046 2020
46
Skeletal Muscle Metastasis in Papillary Thyroid Microcarcinoma Evaluated by F18-FDG PET/CT. 61
32059570 2020
47
Diagnostic Accuracy of Contrast-Enhanced Ultrasonography in Papillary Thyroid Microcarcinoma Stratified by Size. 61
31703968 2020
48
Randomized trial of prophylactic ipsilateral central lymph node dissection in patients with clinically node negative papillary thyroid microcarcinoma. 61
31664515 2020
49
Survival with Follicular and Hurthle Cell Microcarcinoma Compared to Papillary Thyroid Microcarcinoma: A Population Study of 84,532 Patients. 61
31863140 2020
50
Does the ATA Risk Stratification Apply to Patients with Papillary Thyroid Microcarcinoma? 61
31605172 2020

Variations for Papillary Thyroid Microcarcinoma

Expression for Papillary Thyroid Microcarcinoma

Search GEO for disease gene expression data for Papillary Thyroid Microcarcinoma.

Pathways for Papillary Thyroid Microcarcinoma

Pathways related to Papillary Thyroid Microcarcinoma according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1 12.46 MET HGF CRKL BRAF
2
Show member pathways
12.44 NQO1 MET HGF BRAF
3
Show member pathways
12.4 MET HGF CRKL BRAF
4 12.38 NQO1 MET HGF CRKL BRAF
5
Show member pathways
12.36 MET HGF CRKL BRAF
6
Show member pathways
12.18 MET HGF CRKL BRAF
7 11.7 TP63 MET HGF
8 11.05 TP63 MET HGF EPCAM
9 10.99 MET HGF
10 10.66 TSHR MET HGF
11 10.6 MET HGF
12 9.93 TSHR TG

GO Terms for Papillary Thyroid Microcarcinoma

Biological processes related to Papillary Thyroid Microcarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 aging GO:0007568 9.63 TP63 NQO1 CALCA
2 establishment of skin barrier GO:0061436 9.43 TP63 MET
3 pattern specification process GO:0007389 9.43 TP63 NKX2-1 CRKL
4 anatomical structure formation involved in morphogenesis GO:0048646 9.4 TP63 NKX2-1
5 hepatocyte growth factor receptor signaling pathway GO:0048012 9.37 MET HGF
6 cranial skeletal system development GO:1904888 9.32 TP63 CRKL
7 animal organ morphogenesis GO:0009887 9.26 TP63 NKX2-1 CRKL BRAF
8 negative regulation of hydrogen peroxide-mediated programmed cell death GO:1901299 9.16 MET HGF
9 thyroid gland development GO:0030878 8.8 TG NKX2-1 BRAF

Molecular functions related to Papillary Thyroid Microcarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex binding GO:0044877 9.35 TSHR HGF EPCAM CALCA BRAF
2 identical protein binding GO:0042802 9.23 TP63 TG NQO1 MET HGF CRKL

Sources for Papillary Thyroid Microcarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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