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MCID: PPL021
MIFTS: 49

Papilledema

Categories: Rare diseases, Neuronal diseases, Eye diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Papilledema

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MalaCards integrated aliases for Papilledema:

Name: Papilledema 12 76 53 29 55 15 73
Edema of the Optic Disc 53
Choked Disk 53

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Eye diseases
See all MalaCards categories (disease lists)
ICD10: 33


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Summaries for Papilledema

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NIH Rare Diseases : 53 Papilledema is a condition in which increased pressure in or around the brain (intracranial pressure) causes swelling of the part of the optic nerve inside the eye (optic disc). Symptoms of increased intracranial pressure include headache or nausea and vomiting. Vision problems are not common initially, but may include short flickers of gray vision, blurred or double vision, and decreased field of vision or ability to see colors. Both eyes are usually affected. Papilledema by definition is caused by increased cranial pressure. Diagnosis includes a thorough eye exam by an ophthalmologist. Brain imaging studies (for example CT scan or MRI) are used to find the cause of the increased intracranial pressure. Treatment depends on the cause of the increased pressure but may include medications, surgery and/or weight management.

MalaCards based summary : Papilledema, also known as edema of the optic disc, is related to intracranial hypertension and ischemic optic neuropathy, and has symptoms including edema An important gene associated with Papilledema is TP53 (Tumor Protein P53), and among its related pathways/superpathways is IL1 and megakaryocytes in obesity. The drugs Acetazolamide and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and ovary, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Papilledema (or papilloedema) is optic disc swelling that is caused by increased intracranial pressure... more...

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Related Diseases for Papilledema

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Diseases related to Papilledema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 194)
# Related Disease Score Top Affiliating Genes
1 intracranial hypertension 31.1 APOH F2
2 ischemic optic neuropathy 30.2 APOH F2
3 thrombophilia due to thrombin defect 30.1 APOH F2
4 cerebral sinovenous thrombosis 30.1 APOH F2
5 retinal vascular occlusion 30.0 APOH F2
6 intracranial hypertension, idiopathic 29.1 OGG1 PCLO SEMA6B
7 hydrocephalus 11.3
8 papilloma of choroid plexus 11.1
9 optic papillitis 11.1
10 colloid cysts of third ventricle 10.9
11 anterior cranial fossa meningioma 10.6 F2 TP53
12 spinal cord infarction 10.5 APOH F2
13 livedoid vasculopathy 10.5 APOH F2
14 squamous cell papilloma 10.5 F2 TP53
15 splenic infarction 10.5 APOH F2
16 prothrombin deficiency, congenital 10.5 APOH F2
17 ischemic colitis 10.5 APOH F2
18 sneddon syndrome 10.5 APOH F2
19 retinal artery occlusion 10.5 APOH F2
20 buerger disease 10.5 APOH F2
21 hepatic infarction 10.5 APOH F2
22 thrombophlebitis 10.5 APOH F2
23 prothrombin deficiency 10.5 APOH F2
24 antithrombin iii deficiency 10.5 APOH F2
25 peripheral vertigo 10.5 APOH F2
26 central retinal vein occlusion 10.5 APOH F2
27 branch retinal artery occlusion 10.5 APOH F2
28 portal vein thrombosis 10.4 APOH F2
29 protein s deficiency 10.4 APOH F2
30 placental abruption 10.4 APOH F2
31 infective endocarditis 10.4 APOH F2
32 cholecystitis 10.4 F2 TP53
33 intermittent claudication 10.3 APOH F2
34 barrett's adenocarcinoma 10.3 OGG1 TP53
35 retinal vein occlusion 10.3 APOH F2
36 thrombophilia due to activated protein c resistance 10.3 APOH F2
37 budd-chiari syndrome 10.2 APOH F2
38 streptococcal meningitis 10.2 IL1R1 MYOM2
39 mature b-cell neoplasm 10.1 MYOM2 TP53
40 pseudopapilledema 10.1
41 cerebritis 10.1
42 endocarditis 10.1 APOH F2
43 headache 10.1
44 thrombosis 10.1
45 retinitis 10.1
46 antiphospholipid syndrome 10.0 APOH F2
47 craniosynostosis 10.0
48 cataract 10.0
49 meningitis 9.9
50 pulmonary embolism 9.9 APOH F2

Graphical network of the top 20 diseases related to Papilledema:



Diseases related to Papilledema
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Symptoms & Phenotypes for Papilledema

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UMLS symptoms related to Papilledema:


edema

GenomeRNAi Phenotypes related to Papilledema according to GeneCards Suite gene sharing:

26 (show all 27)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.81 PCLO
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.81 ARSB
3 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.81 ARSB
4 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.81 IL1R1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.81 IL1R1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.81 IL1R1 PCLO ARSB F2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.81 IL1R1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.81 ARSB F2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-133 9.81 F2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.81 F2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.81 F2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.81 PCLO
13 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.81 PCLO
14 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.81 IL1R1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.81 F2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-183 9.81 IL1R1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.81 IL1R1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.81 PCLO
19 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.81 IL1R1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.81 ARSB
21 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.81 ARSB F2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.81 PCLO
23 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.81 ARSB
24 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.81 IL1R1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-90 9.81 PCLO
26 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.81 IL1R1
27 Increased proliferation GR00094-A 8.96 IL1R1 TP53

MGI Mouse Phenotypes related to Papilledema:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.17 ARSB F2 IL1R1 OGG1 PCLO SEMA6B
Sources

Drugs & Therapeutics for Papilledema

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Drugs for Papilledema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 100)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetazolamide Approved, Vet_approved Phase 4,Phase 2,Phase 3 59-66-5 1986
2
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
3
Isotretinoin Approved Phase 4 4759-48-2 5538 5282379
4
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
5
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
6 Anticonvulsants Phase 4,Phase 2,Phase 3
7 Carbonic Anhydrase Inhibitors Phase 4,Phase 2,Phase 3
8 diuretics Phase 4,Phase 2,Phase 3
9 Natriuretic Agents Phase 4,Phase 2,Phase 3
10 Anti-Bacterial Agents Phase 4,Phase 2,Not Applicable
11 Anti-Infective Agents Phase 4,Phase 2
12 Dermatologic Agents Phase 4
13
Acetaminophen Approved Phase 2, Phase 3 103-90-2 1983
14
Aspirin Approved, Vet_approved Phase 2, Phase 3,Not Applicable 50-78-2 2244
15
Codeine Approved, Illicit Phase 2, Phase 3 76-57-3 5284371
16
Guaifenesin Approved, Investigational, Vet_approved Phase 2, Phase 3 93-14-1 3516
17
Ibuprofen Approved Phase 2, Phase 3 15687-27-1 3672
18
Naproxen Approved, Vet_approved Phase 2, Phase 3 22204-53-1 1302 156391
19
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3 50-02-2 5743
20
Warfarin Approved Phase 3 81-81-2 6691 54678486
21
Serine Approved, Nutraceutical Phase 3 56-45-1 5951
22 Analgesics Phase 2, Phase 3,Not Applicable
23 Analgesics, Non-Narcotic Phase 2, Phase 3,Not Applicable
24 Anti-Inflammatory Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
25 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3,Not Applicable
26 Antirheumatic Agents Phase 2, Phase 3,Phase 1,Not Applicable
27 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3,Not Applicable
28 glucocorticoids Phase 2, Phase 3,Phase 1
29 Hormone Antagonists Phase 2, Phase 3,Phase 1
30 Hormones Phase 2, Phase 3,Phase 1
31 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3,Phase 1
32 Analgesics, Opioid Phase 2, Phase 3
33 Antipyretics Phase 2, Phase 3
34 Antitussive Agents Phase 2, Phase 3
35 Central Nervous System Depressants Phase 2, Phase 3
36 Chlorpheniramine, phenylpropanolamine drug combination Phase 2, Phase 3
37 Cyclooxygenase Inhibitors Phase 2, Phase 3
38 Fibrinolytic Agents Phase 2, Phase 3
39 Narcotics Phase 2, Phase 3
40 Platelet Aggregation Inhibitors Phase 2, Phase 3
41 Respiratory System Agents Phase 2, Phase 3
42 Antiemetics Phase 2, Phase 3
43 Antineoplastic Agents, Hormonal Phase 2, Phase 3
44 Autonomic Agents Phase 2, Phase 3
45 BB 1101 Phase 2, Phase 3
46 Dexamethasone acetate Phase 2, Phase 3 1177-87-3
47 Gastrointestinal Agents Phase 2, Phase 3
48 HIV Protease Inhibitors Phase 2, Phase 3,Phase 3
49
protease inhibitors Phase 2, Phase 3,Phase 3
50 Anticoagulants Phase 3,Phase 2

Interventional clinical trials:

(show all 37)
# Name Status NCT ID Phase Drugs
1 ALPI vs Medical Therapy Effects on Optic Nerve Structure & Function Unknown status NCT00485238 Phase 4 Intravenous acetazolamide
2 Pegaptanib for Retinal Edema Secondary to Diabetic Vascular Disease(Preserve) Study Completed NCT01486238 Phase 4 Macugen® pegaptanib sodium
3 Antiacne Medications Pseudotumor Cerebri Recruiting NCT02149615 Phase 4
4 Idiopathic Intracranial Hypertension Treatment Trial Completed NCT01003639 Phase 2, Phase 3 Acetazolamide;Placebo
5 Ozurdex for Macular Edema Post Membrane Peeling Completed NCT01273727 Phase 2, Phase 3 Dexamethasone;dexamethasone
6 The Efficacy and Safety of Dabigatran Etexilate for the Treatment of Cerebral Venous Thrombosis Recruiting NCT03217448 Phase 3 Dabigatran etexilate;Warfarin
7 Surgical Idiopathic Intracranial Hypertension Treatment Trial Not yet recruiting NCT03501966 Phase 3 Acetazolamide
8 Comparison of Intravitreal Bevacizumab and Triamcinolone With Placebo Unknown status NCT01330524 Phase 1, Phase 2 Avastin and Triamcinolone
9 Safety and Effectiveness of 11b-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) to Treat Idiopathic Intracranial Hypertension. Completed NCT02017444 Phase 2 AZD4017
10 Efficacy of Biweekly Ranibizumab (0.5 mg) for Exudative Macular Degeneration Retinal Edema Refractory to Anti-VEGF Recruiting NCT03071055 Phase 2 Ranibizumab Injection [Lucentis]
11 Intravitreal Aflibercept Injection for Radiation Retinopathy Trial Recruiting NCT03085784 Phase 2 Aflibercept
12 Ixazomib Citrate, Lenalidomide, and Dexamethasone in Treating Patients With POEMS Syndrome Recruiting NCT02921893 Phase 2 Dexamethasone;Ixazomib Citrate;Lenalidomide
13 Anakinra to Treat Patients With Neonatal Onset Multisystem Inflammatory Disease Terminated NCT00069329 Phase 1, Phase 2 anakinra
14 Safety Study of Fluconazole in Combination With Flucytosine for the Treatment of Early Cryptococcal Infection Terminated NCT01562132 Phase 2 Flucytosine and fluconazole;Fluconazole
15 Endovascular Stenting Treatment for Patients With Internal Jugular Vein Stenosis Not yet recruiting NCT03373292 Phase 1
16 aICP in Glaucoma and Papilledema Unknown status NCT02410148 Not Applicable
17 OCT Imaging of Papilledema in Pediatric Idiopathic Intracranial Hypertension Unknown status NCT02665858 Not Applicable
18 Prolensa (Bromfenac) 0.07% QD vs. Ilevro (Nepafenac) 0.3% QD for Treatment of Ocular Inflammation Post Cataract Surgery Unknown status NCT01847638 Not Applicable Prolensa (bromfenac 0.07%);Ilevro (nepafenac 0.3%)
19 Assessment of Retinal Nerve Fibre Layer by Optical Coherence Tomography in Uveitis Patients With Papilloedema Completed NCT01170481
20 Digital Ocular Fundus Photography in the Emergency Department: A New Application for Telemedicine? Completed NCT00873613 Not Applicable
21 Vascular Fundus Changes in Patients With High Probability of Chronic Cerebrospinal Venous Insufficiency (CCSVI) Completed NCT01356134
22 Observe the Effectiveness and Safety of Ranibizumab in Real Life Setting Completed NCT01318941 Ranibizumab
23 Cerebral Venous Sinus Thrombosis: Re-exploration of Clinical Assessment Scales Recruiting NCT03273179
24 Measurement of Optic Nerve Sheath Diameter in Children Without the Increased Intracranial Pressure Recruiting NCT03178760
25 An RCT of Bariatric Surgery vs a Community Weight Loss Programme for the Sustained Treatment of IIH Recruiting NCT02124486 Not Applicable
26 Astronaut Vision Issues in a Ground Analog Population: Polycystic Ovary Syndrome Recruiting NCT02896452
27 Studies of the Natural History, Pathogenesis, and Outcome of Autoinflammatory Diseases (NOMID / CAPS, DIRA, CANDLE, SAVI, CRMO, Still's Disease, Behcet's Disease, and Other Undifferentiated Autoinflammatory Diseases) Recruiting NCT00059748
28 Evaluating Raised Intracranial Pressure Using MR Elastography Recruiting NCT03096743 Not Applicable
29 Effectiveness of Multimodal Imaging for the Evaluation of Retinal Oedema And New vesseLs in Diabetic Retinopathy Recruiting NCT03490318
30 Korean Registry of Target Organ Damages in Hypertension Recruiting NCT01861080
31 Stenting of Venous Sinus Stenosis for Medically Refractory Idiopathic Intracranial Hypertension Recruiting NCT02143258 Not Applicable
32 A Single-Center Trial of High Frequency Pegaptanib for Rapid Restoration of VEGF Levels in Diabetic Retinal Edema Available NCT01487044 Macugen (Pegaptanib Sodium)
33 Ocular Point of Care Ultrasound (POCUS) to Detect Optic Disc Swelling in Comparison to Ophthalmologic Examination Not yet recruiting NCT02992262 Not Applicable
34 Operative Procedures vs. Endovascular Neurosurgery for Untreated Pseudotumor Trial Not yet recruiting NCT02513914 Not Applicable
35 Venous Sinus Stenting With the River Stent in IIH Not yet recruiting NCT03556085 Not Applicable
36 Quality and Diagnostic Utility of Mydriatic Fundus Plenoptic Photography Suspended NCT03037268
37 Disc Edema in Patients With Chronic Kidney Disease Withdrawn NCT00769834

Search NIH Clinical Center for Papilledema

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Genetic Tests for Papilledema

About this section

Genetic tests related to Papilledema:

# Genetic test Affiliating Genes
1 Papilledema 29
Sources

Anatomical Context for Papilledema

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MalaCards organs/tissues related to Papilledema:

41
Eye, Brain, Ovary, Spinal Cord, Kidney, Retina, Prostate
Sources

Publications for Papilledema

About this section

Articles related to Papilledema:

(show top 50) (show all 515)
# Title Authors Year
1
Papilledema: Point-of-Care Ultrasound Diagnosis in the Emergency Department. ( 29849246 )
2018
2
Papilledema in Idiopathic Intracranial Hypertension. ( 29399792 )
2018
3
Optic Nerve Head and Macular Optical Coherence Tomography Measurements in Papilledema Compared With Pseudopapilledema. ( 29474199 )
2018
4
Bruch's membrane opening on optical coherence tomography in pediatric papilledema and pseudopapilledema. ( 29535052 )
2018
5
Chronic papilledema in a child with classical tuberous sclerosis. ( 29283138 )
2018
6
Re: Chang etA al.: Accuracy of diagnostic imaging modalities for classifying pediatric eyes as papilledema versus pseudopapilledema (Ophthalmology. 2017;124:1839-1848). ( 29458838 )
2018
7
The Translaminar Pressure Gradient: Papilledema after Trabeculectomy Treated with Optic Nerve Sheath Fenestration. ( 29979338 )
2018
8
Young Man With Severe Bilateral Papilledema. ( 29800986 )
2018
9
Papilledema revisiting after sinus angioplasty of chronic cerebral venous sinus thrombosis. ( 29676328 )
2018
10
Rapid effect of depletive lumbar puncture on papilledema in intracranial hypertension. ( 29903588 )
2018
11
Five-Year-Old Boy With Behavioral Changes and Papilledema. ( 28991098 )
2018
12
Arteriovenous ratio and papilledema based hybrid decision support system for detection and grading of hypertensive retinopathy. ( 29249337 )
2018
13
Syphilis-Related Eye Disease Presenting as Bilateral Papilledema, Retinal Nerve Fiber Layer Hemorrhage, and Anterior Uveitis in a Penicillin-Allergic Patient. ( 29670780 )
2018
14
Headache and Papilledema in Guillain-BarrAc Syndrome. ( 29374500 )
2018
15
Bruch's membrane opening on optical coherence tomography in pediatric papilledema and pseudopapilledema. ( 29535053 )
2018
16
Decision Support System for Detection of Papilledema through Fundus Retinal Images. ( 28283997 )
2017
17
Unexpected papilledema in a young male with Type 1 diabetes. ( 28781853 )
2017
18
"Twin Peaks" Papilledema. ( 28126073 )
2017
19
Relationship between lamina cribrosa displacement and trans-laminar pressure difference in papilledema. ( 28391369 )
2017
20
Factors Influencing the Incidence of Papilledema in Patients with Cerebral Venous Thrombosis. ( 29387676 )
2017
21
Fully automated diagnosis of papilledema through robust extraction of vascular patterns and ocular pathology from fundus photographs. ( 28270999 )
2017
22
Vestibular Schwannoma Presenting with Bilateral Papilledema Without Hydrocephalus: Case Study. ( 29375948 )
2017
23
Optical Coherence Tomography to Differentiate Papilledema from Pseudopapilledema. ( 28819712 )
2017
24
Commentary: The Dilemma of Papilledema in Chiari I Malformation. ( 29272471 )
2017
25
Retrospective analysis of translaminar, demographic, and physiologic parameters in relation to papilledema severity. ( 28237144 )
2017
26
Papilledema in children with hydrocephalus: incidence and associated factors. ( 28387641 )
2017
27
Utility of Intracranial Pressure Monitoring for Diagnosis of Idiopathic Intracranial Hypertension in the Absence of Papilledema. ( 29258930 )
2017
28
The diagnostic challenge of evaluating papilledema in the pediatric patient. ( 29018749 )
2017
29
Complete Resolution of Papilledema in Syndromic Craniosynostosis with Posterior Cranial Vault Distraction. ( 28904587 )
2017
30
Clinical Reasoning: A 57-year-old man with unilateral anosmia, papilledema, and meningismus. ( 28827465 )
2017
31
Sildenafil-related cerebral venous sinus thrombosis and papilledema: a case report of a rare entity. ( 28474148 )
2017
32
Accuracy of Diagnostic Imaging Modalities for Classifying Pediatric Eyes as Papilledema Versus Pseudopapilledema. ( 28732589 )
2017
33
Accuracy of crescent sign on ocular ultrasound in diagnosing papilledema. ( 29026691 )
2017
34
Bruch's membrane opening on optical coherence tomography in pediatric papilledema and pseudopapilledema. ( 29203329 )
2017
35
Papilledema: A Comprehensive Assessment. ( 29204042 )
2017
36
Myhre syndrome with novel findings: bilateral congenital cortical cataract, bilateral papilledema, accessory nipple, and adenoid hypertrophy. ( 28562390 )
2017
37
Orbital Hydatid Cyst Causing Papilledema and Proptosis in an Adult. ( 28323190 )
2017
38
Unilateral Papilledema in Cerebral Venous Sinus Thrombosis. ( 28936083 )
2017
39
Hypoparathyroidism Should Always Be Checked in Papilledema. ( 28694607 )
2017
40
New-Onset Isolated Asymptomatic Papilledema in Two Patients Treated With Recombinant Growth Hormone. ( 28952359 )
2017
41
The efficacy of orbital ultrasonography and magnetic resonance imaging findings with direct measurement of intracranial pressure in distinguishing papilledema from pseudopapilledema. ( 28534259 )
2017
42
Use of A-scan Ultrasound and Optical Coherence Tomography to Differentiate Papilledema From Pseudopapilledema. ( 29120977 )
2017
43
Objective Measures of Visual Function in Papilledema. ( 28451649 )
2016
44
Papilledema secondary to a superior sagittal sinus thrombosis. Mantle cell lymphoma paraneoplastic syndrome. ( 26596713 )
2016
45
Idiopathic Intracranial Hypertension in a Prepubertal Pediatric Japanese Patient Complicated by Severe Papilledema. ( 27065853 )
2016
46
Asymmetric Papilledema in Idiopathic Intracranial Hypertension: Comment. ( 26885711 )
2016
47
Measuring recovery of visual function in children with papilledema using sweep visual evoked potentials. ( 27164429 )
2016
48
Abnormal transcranial Doppler cerebral blood flow velocity and blood pressure profiles in children with syndromic craniosynostosis and papilledema. ( 26857754 )
2016
49
Bilateral papilledema in a child with osteogenesis imperfecta. ( 27833926 )
2016
50
Severe bilateral papilledema in acute lymphoblastic leukemia. ( 26873026 )
2016
Sources

Variations for Papilledema

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Expression for Papilledema

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Search GEO for disease gene expression data for Papilledema.
Sources

Pathways for Papilledema

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Pathways related to Papilledema according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
IL1 and megakaryocytes in obesity 1
10.02 F2 IL1R1
Sources

GO Terms for Papilledema

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Biological processes related to Papilledema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide-excision repair GO:0006289 9.4 OGG1 TP53
2 base-excision repair GO:0006284 9.37 OGG1 TP53
3 positive regulation of reactive oxygen species metabolic process GO:2000379 9.32 F2 TP53
4 blood coagulation, intrinsic pathway GO:0007597 9.26 APOH F2
5 positive regulation of blood coagulation GO:0030194 9.16 APOH F2
6 regulation of blood coagulation GO:0030193 8.96 APOH F2
7 negative regulation of fibrinolysis GO:0051918 8.62 APOH F2

Molecular functions related to Papilledema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 damaged DNA binding GO:0003684 8.62 OGG1 TP53
Sources

Sources for Papilledema

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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