Papilledema disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PPL021 MIFTS: 50	Papilledema Categories: Eye diseases, Neuronal diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Papilledema

MalaCards integrated aliases for Papilledema:

Name: Papilledema ¹¹ ¹⁹ ⁷⁵ ²⁸ ⁵³ ¹⁴ ⁷¹

Edema of the Optic Disc ¹⁹

Choked Disk ¹⁹

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Eye diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Diseases of the eye and adnexa

Disorders of optic nerve and visual pathways

Other disorders of optic [2nd] nerve and visual pathways

Papilloedema, unspecified

External Ids:

Disease Ontology ¹¹ DOID:146

ICD9CM ³⁴ 377.0

MeSH ⁴³ D010211

NCIt ⁴⁹ C3307

SNOMED-CT ⁶⁸ 423341008

ICD10 ³¹ H47.1

UMLS ⁷¹ C0030353

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Summaries for Papilledema

GARD: ¹⁹ Papilledema is a condition in which increased pressure in or around the brain (intracranial pressure) causes swelling of the part of the optic nerve inside the eye (optic disc). Symptoms of increased intracranial pressure include headache or nausea and vomiting. Vision problems are not common initially, but may include short flickers of gray vision, blurred or double vision, and decreased field of vision or ability to see colors. Both eyes are usually affected. Papilledema by definition is caused by increased cranial pressure. Diagnosis includes a thorough eye exam by an ophthalmologist. Brain imaging studies (for example CT scan or MRI) are used to find the cause of the increased intracranial pressure.

MalaCards based summary: Papilledema, also known as edema of the optic disc, is related to optic papillitis and poems syndrome, and has symptoms including edema An important gene associated with Papilledema is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Innate Immune System and Response to elevated platelet cytosolic Ca2+. The drugs Lymecycline and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and endothelial, and related phenotypes are homeostasis/metabolism and nervous system

Wikipedia: ⁷⁵ Papilledema or papilloedema is optic disc swelling that is caused by increased intracranial pressure due... more...

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Related Diseases for Papilledema

Diseases related to Papilledema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1011)

#	Related Disease	Score	Top Affiliating Genes
1	optic papillitis	31.4	NLRP3 MOG CRP AQP4 ACE
2	poems syndrome	31.3	VEGFA MYOM2 IL6
3	hydrocephalus	30.8	VEGFA TP53 SYP SERPINA3 AQP4 ACE
4	thrombophilia due to thrombin defect	30.7	SERPINC1 F3 F2 APOH
5	thrombosis	30.3	SERPINC1 SERPINA3 JAK2 F3 F2 APOH
6	lateral sinus thrombosis	30.3	SERPINC1 F2
7	nonarteritic anterior ischemic optic neuropathy	30.2	VEGFA SERPINC1 MOG F2 CRP AQP4
8	abducens palsy	30.2	SERPINC1 MOG F2 CRP AQP4
9	intracranial hypertension	30.1	SERPINC1 IL6 F3 F2 CRP AQP4
10	cauda equina syndrome	30.1	SYP F3 F2 CRP
11	neuritis	30.0	VEGFA MOG IL6 AQP4
12	communicating hydrocephalus	30.0	SERPINA3 AQP4 ALB
13	optic neuritis	29.9	VEGFA MOG IL6 AQP4
14	arteriovenous malformation	29.9	VEGFA SERPINA3 F3 F2 ALB
15	polycythemia	29.8	VEGFA JAK2 F3 F2 CRP ACE
16	sagittal sinus thrombosis	29.8	SERPINC1 JAK2 F3 F2 CRP APOH
17	antiphospholipid syndrome	29.8	SERPINC1 F3 F2 CRP APOH
18	syphilis	29.8	CRP APOH ALB ACE
19	subdural empyema	29.8	F2 CRP
20	mastoiditis	29.8	SERPINC1 F3 F2 CRP
21	multiple cranial nerve palsy	29.8	CRP ACE
22	neurosarcoidosis	29.7	MOG CRP AQP4 ACE
23	hypertensive retinopathy	29.7	VEGFA CRP ALB ACE
24	macular dystrophy, dominant cystoid	29.7	VEGFA IL6 ACE
25	polyarteritis nodosa	29.7	IL6 CRP APOH
26	choroiditis	29.7	VEGFA CRP ACE
27	brucellosis	29.7	NLRP3 IL6 CRP
28	brain cancer	29.6	VEGFA TP53 SYP STAT3 AQP4
29	cardiomyopathy, familial hypertrophic, 20	29.6	F2 ALB
30	vasculitis	29.6	SERPINA3 IL6 CRP APOH
31	hemangioblastoma	29.6	VEGFA SYP STAT3 JAK2
32	macular retinal edema	29.6	VEGFA IL6 ALB ACE
33	granulomatous angiitis	29.6	CRP ACE
34	hyperhomocysteinemia	29.6	SERPINC1 F2 CRP APOH ALB
35	acute retrobulbar neuritis	29.5	MOG AQP4 ACE
36	neuroretinitis	29.5	VEGFA MOG CRP AQP4 ACE
37	radiculopathy	29.5	IL6 IL1R1 CRP
38	vascular cancer	29.5	VEGFA TP53 SYP SERPINA3
39	chorioretinitis	29.4	VEGFA IL6 CRP ACE
40	osteosclerotic myeloma	29.4	VEGFA MYOM2 IL6
41	pulmonary emphysema	29.4	VEGFA SERPINA3 ALB
42	meningitis	29.3	VEGFA NLRP3 IL6 CRP AQP4 ALB
43	acquired immunodeficiency syndrome	29.3	TP53 IL6 CRP ALB
44	intracranial hypotension	29.3	SERPINC1 F3 F2 CRP ALB
45	hemorrhagic disease	29.3	SERPINC1 F3 F2 CRP ALB
46	castleman disease	29.3	VEGFA MYOM2 IL6 CRP
47	chronic fatigue syndrome	29.3	SERPINA3 IL6 CRP
48	diastolic heart failure	29.3	IL6 CRP ACE
49	posterior uveitis	29.2	VEGFA IL6 ACE
50	middle east respiratory syndrome	29.2	IL6 CRP ACE

Graphical network of the top 20 diseases related to Papilledema:

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Symptoms & Phenotypes for Papilledema

UMLS symptoms related to Papilledema:

edema

GenomeRNAi Phenotypes related to Papilledema according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.2	ACE ALB APOH AQP4 ARSB CRP
2	no effect	GR00402-S-2	10.2	ACE ALB APOH AQP4 CRP F2

MGI Mouse Phenotypes related to Papilledema:

⁴⁵ (show all 21)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.47	ACE ALB APOH AQP4 ARSB CRP
2	nervous system	MP:0003631	10.43	AQP4 ARSB F2 F3 IL1R1 IL6
3	growth/size/body region	MP:0005378	10.37	ACE AQP4 ARSB F2 F3 IL1R1
4	renal/urinary system	MP:0005367	10.32	ACE ALB AQP4 ARSB IL1R1 IL6
5	cellular	MP:0005384	10.32	ACE ALB ARSB F2 F3 IL1R1
6	muscle	MP:0005369	10.31	ALB ARSB F2 F3 IL1R1 IL6
7	immune system	MP:0005387	10.31	ACE ALB AQP4 CRP F2 F3
8	cardiovascular system	MP:0005385	10.3	ACE ALB AQP4 ARSB CRP F2
9	normal	MP:0002873	10.29	ALB F2 F3 IL1R1 JAK2 NLRP3
10	behavior/neurological	MP:0005386	10.28	ACE AQP4 ARSB F2 F3 IL1R1
11	liver/biliary system	MP:0005370	10.26	ACE ALB IL1R1 IL6 JAK2 NLRP3
12	neoplasm	MP:0002006	10.25	ACE ALB F3 IL1R1 IL6 JAK2
13	endocrine/exocrine gland	MP:0005379	10.21	ACE ALB AQP4 F2 IL1R1 IL6
14	adipose tissue	MP:0005375	10.15	ACE ARSB F2 IL1R1 IL6 NLRP3
15	digestive/alimentary	MP:0005381	10.15	ALB AQP4 F2 IL1R1 IL6 NLRP3
16	respiratory system	MP:0005388	10.07	AQP4 ARSB F2 F3 IL1R1 IL6
17	reproductive system	MP:0005389	10.06	ACE AQP4 ARSB F2 IL6 JAK2
18	hematopoietic system	MP:0005397	10.03	ACE AQP4 ARSB F2 F3 IL1R1
19	vision/eye	MP:0005391	10	AQP4 ARSB F3 IL1R1 IL6 MOG
20	mortality/aging	MP:0010768	9.8	ACE ALB APOH AQP4 F2 F3
21	integument	MP:0010771	9.36	F2 F3 IL1R1 IL6 JAK2 MYOM2

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Drugs & Therapeutics for Papilledema

Drugs for Papilledema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Lymecycline

Approved, Investigational

Phase 4

992-21-2

Doxycycline

Approved, Investigational, Vet_approved

Phase 4

564-25-0

54671203

Minocycline

Approved, Investigational

Phase 4

10118-90-8, 13614-98-7

54675783 5281021

Prednisolone phosphate

Approved, Vet_approved

Phase 4

302-25-0

Prednisolone acetate

Approved, Vet_approved

Phase 4

52-21-1

Prednisolone

Approved, Vet_approved

Phase 4

50-24-8

4894 5755

Prednisone

Approved, Vet_approved

Phase 4

53-03-2

5865

Methylprednisolone hemisuccinate

Approved

Phase 4

2921-57-5

1875

Methylprednisolone

Approved, Vet_approved

Phase 4

83-43-2

4159 6741

Ranibizumab

Approved

Phase 4

347396-82-1

Isotretinoin

Approved, Investigational, Nutraceutical

Phase 4

302-79-4, 4759-48-2

5538 444795 5282379

Prednisolone hemisuccinate

Experimental

Phase 4

2920-86-7

4897

Methylprednisolone Acetate

Phase 4

584547

Angiogenesis Inhibitors

Phase 4

Pharmaceutical Solutions

Phase 4

Endothelial Growth Factors

Phase 4

Mitogens

Phase 4

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 2, Phase 3

1177-87-3

3680

Dexamethasone

Approved, Investigational, Vet_approved

Phase 2, Phase 3

50-02-2

3003 5743

Anti-Inflammatory Agents

Phase 2, Phase 3

Hormones

Phase 2, Phase 3

Hormone Antagonists

Phase 2, Phase 3

glucocorticoids

Phase 2, Phase 3

Antineoplastic Agents, Hormonal

Phase 2, Phase 3

Antiemetics

Phase 2, Phase 3

HIV Protease Inhibitors

Phase 2, Phase 3

BB 1101

Phase 2, Phase 3

Gastrointestinal Agents

Phase 2, Phase 3

protease inhibitors

Phase 2, Phase 3

Antirheumatic Agents

Phase 1, Phase 2

Interleukin 1 Receptor Antagonist Protein

Phase 1, Phase 2

Levoleucovorin

Approved, Experimental, Investigational

Phase 1

68538-85-2, 58-05-9, 73951-54-9

149436 6006

Flavin mononucleotide

Approved, Investigational

Phase 1

146-17-8

643976

Mecobalamin

Approved, Investigational

Phase 1

13422-55-4

Folic acid

Approved, Nutraceutical, Vet_approved

Phase 1

59-30-3

6037

Pyridoxine

Approved, Investigational, Nutraceutical, Vet_approved

Phase 1

65-23-6

1054

Pyridoxal phosphate

Approved, Investigational, Nutraceutical

Phase 1

54-47-7

1051

Cyanocobalamin

Approved, Nutraceutical

Phase 1

68-19-9

24892734 16212801 44176380

Vitamin A

Approved, Nutraceutical, Vet_approved

Phase 1

22737-96-8, 68-26-8

5280382 445354

Riboflavin

Approved, Investigational, Nutraceutical, Vet_approved

Phase 1

83-88-5

493570

Cobalamin

Experimental

Phase 1

13408-78-1

6857388

Folate

Phase 1

Vitamins

Phase 1

Vitamin B9

Phase 1

Vitamin B6

Phase 1

Trace Elements

Phase 1

Vitamin B2

Phase 1

Vitamin B12

Phase 1

Vitamin B Complex

Phase 1

Vitamin B 6

Phase 1

Interventional clinical trials:

(show all 23)

#	Name	Status	NCT ID	Phase	Drugs
1	Prospective Open-label Phase IV Trial to Investigate the Frequency of Optic Disc Swelling, Idiopathic Intracranial Hypertension and Dry Eye Symptoms Under Antiacne Medication Treatment	Unknown status	NCT02149615	Phase 4
2	Assessing the Efficacy and Safety fo DEXTENZA, Sustained Release Dexamethasone 0.4 mg Insert(s) When Placed Within the Lower Eye Lid Canaliculus or Both the Upper and Lower Canaliculi for the Treatment of Pain, Inflammation, and Cystoid Macular Edema Following 27 Gauge Vitrectomy With Internal Limiting Membrane Peel for the Treatment of Retinal Edema Associated With Macular Pucker.	Unknown status	NCT04501367	Phase 4	Dexamethasone Intracanalicular Insert, 0.4 mg;Prednisone acetate 1%
3	Treatment of Diabetic Macular Edema (DME) With Intravitreal Anti-vascular Endothelial Growth Factor (Anti-VEGF) and Prompt Versus Deferred Focal Laser During Long-term Follow-up and Identification of Prognostic Retinal Markers	Completed	NCT03590444	Phase 4	Ranibizumab 0.5 MG/0.05 ML Intraocular Solution
4	Pegaptanib for Retinal Edema Secondary to Diabetic Vascular Disease(Preserve) Study	Completed	NCT01486238	Phase 4	Macugen® pegaptanib sodium
5	Ozurdex in Treatment of Macular Edema Post Membrane Peeling	Completed	NCT01273727	Phase 2, Phase 3	Dexamethasone;dexamethasone
6	Efficacy of Biweekly Ranibizumab (0.5 mg) for Exudative Macular Degeneration Retinal Edema Refractory to Anti-VEGF Therapy Comparing Syringe Preparation Time Using Ranibizumab Vial and Pre-filled Syringe	Completed	NCT03071055	Phase 2	Ranibizumab Injection [Lucentis]
7	A Long-Term Outcome Study With the IL-1 Receptor Antagonist Anakinra/Kineret in Patients With Neonatal Onset Multisystem Inflammatory Disease (NOMID/CINCA Syndrome) A Therapeutic Approach to Study the Pathogenesis of This Disease	Terminated	NCT00069329	Phase 1, Phase 2	anakinra
8	Evaluation of the Feasibility, Safety and Efficacy of Venous Stenting for Internal Jugular Vein Stenosis	Unknown status	NCT03373292	Phase 1
9	B-Complex: A Nutraceutical SANS Countermeasure	Recruiting	NCT05366933	Phase 1	Vitamin B-Complex Supplement
10	OCT Imaging of Papilledema in Pediatric Idiopathic Intracranial Hypertension	Unknown status	NCT02665858
11	Non-invasive Absolute Intracranial Pressure (ICP) Measurement in Patients With Open-angle Glaucoma and Papilledema	Unknown status	NCT02410148
12	Cerebral Venous Sinus Thrombosis: Re-exploration of Clinical Assessment	Unknown status	NCT03273179
13	Ocular Point of Care Ultrasound (POCUS) to Detect Optic Disc Swelling in Comparison to Ophthalmologic Examination	Unknown status	NCT02992262
14	Determination of Normal Measures of Optic Nerve Sheath Diameter in Children	Unknown status	NCT03178760
15	Prevalence of Ocular Manifestations in Inflammatory Rheumatic Diseases	Completed	NCT03753893
16	Clinical Outcomes of Prolensa (Bromfenac Ophthalmic Solution) 0.07% QD vs. Ilevro (Nepafenac Ophthalmic Suspension) 0.3% QD for Treatment of Ocular Inflammation Associated With Cataract Surgery	Completed	NCT01847638		Prolensa (bromfenac 0.07%);Ilevro (nepafenac 0.3%)
17	LUMINOUS: Study to Observe the Effectiveness and Safety of Ranibizumab Through Individualized Patient Treatment and Associated Outcomes	Completed	NCT01318941		Ranibizumab
18	Retinal Nerve Fibre Layer in Uveitic Secondary Glaucoma	Completed	NCT01170481
19	Effectiveness of Multimodal Imaging for the Evaluation of Retinal Oedema And New vesseLs in Diabetic Retinopathy	Completed	NCT03490318
20	Precise High Resolution MRI to Increase Accuracy and Gain Confidence to Diagnose Patients With Optic Disc Edema	Recruiting	NCT04448613
21	Investigation of Retinal Pathology in Eye Diseases Using High Resolution Optical Coherence Tomography (High-Res-OCT)	Recruiting	NCT05130385
22	A Single-Center Trial of High Frequency Pegaptanib for Rapid Restoration of VEGF Levels in Diabetic Retinal Edema	Available	NCT01487044		Macugen (Pegaptanib Sodium)
23	Resistant Diabetic Macular Edema and Suprachoroidal Injection	Not yet recruiting	NCT04690608	Early Phase 1	Triamcinolone Acetonide 40Mg/Ml Inj,Susp_#1

Search NIH Clinical Center for Papilledema

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Genetic Tests for Papilledema

Genetic tests related to Papilledema:

#	Genetic test	Affiliating Genes
1	Papilledema ²⁸

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Anatomical Context for Papilledema

Organs/tissues related to Papilledema:

MalaCards : Eye, Brain, Endothelial, Spinal Cord, Pineal, Retina, Lymph Node

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Publications for Papilledema

Articles related to Papilledema:

(show top 50) (show all 3341)

#	Title	Authors	PMID	Year
1	A randomized, double blind, placebo-controlled trial on safety and efficacy of recombinant human insulin-like growth factor-I in children with growth hormone receptor deficiency. ⁵³ ⁶²	Guevara-Aguirre J...Rosenfeld RG	7536209	1995
2	Ophthalmoplegia in Patient With Papilledema. ⁶²	Hwang ES...Frohman L	36255092	2022
3	External-internal cranial expansion to treat patients with craniocerebral disproportion due to post-shunt craniosynostosis: a case series. ⁶²	Habibi Z...Nejat F	36456748	2022
4	Interdisciplinary Protocol for the Management of Vision-Threatening Papilledema. ⁶²	Brady T...Katz BJ	35439211	2022
5	Visual outcomes in idiopathic intracranial hypertension in children. ⁶²	Chiu HH...Wan MJ	34283970	2022
6	Features of Idiopathic Intracranial Hypertension on MRI With MR Elastography: Prospective Comparison With Control Individuals and Assessment of Postintervention Changes. ⁶²	Cogswell PM...Chen JJ	35822642	2022
7	Multimodal imaging in differential diagnosis between papilledema and choroidal neovascularization associated with morning glory syndrome. ⁶²	Cennamo G...Costagliola C	36464666	2022
8	Can Lumbar Puncture Be Safely Deferred in Patients With Mild Presumed Idiopathic Intracranial Hypertension? ⁶²	Vosoughi AR...Micieli JA	34860748	2022
9	[Misleading diagnosis of papilledema]. ⁶²	Vandebroek AC...Rickmann A	35179624	2022
10	Bilateral dural arteriovenous fistula diagnosed with neurovascular ultrasonography. ⁶²	Psychogios K...Tsivgoulis G	36465029	2022
11	Progress and Challenges in Bacterial Meningitis: A Review. ⁶²	Hasbun R	36472590	2022
12	Acute Bilateral Vision Loss Following Unilateral Optic Nerve Sheath Fenestration. ⁶²	Levergood N...Lee HBH	35604378	2022
13	Behavioral, Learning Skills, and Visual Improvement in Crouzon Syndrome Patient Following Late Posterior Vault Distraction Osteogenesis. ⁶²	Raposo-Amaral CE...Ghizoni E	36000757	2022
14	Hyphema and secondary glaucoma as a presenting complaint in a dog with chronic lymphocytic leukemia. ⁶²	Dehghanpir SD...Carter RT	36415701	2022
15	Risk factors for the development of secondary intracranial hypertension in acute cerebral venous thrombosis. ⁶²	Schuchardt F...Harloff A	36445465	2022
16	Longstanding overt ventriculomegaly diagnosed in adolescents, not adults: a pediatric case report. ⁶²	Ohashi E...Abe Y	36427075	2022
17	Venous Sinus Stenting for Low Pressure Gradient Stenoses in Idiopathic Intracranial Hypertension. ⁶²	Inam ME...Chen PR	35960743	2022
18	Expanding the clinical spectrum of idiopathic intracranial hypertension. ⁶²	Chen BS...Britton JOT	36444979	2022
19	Neuroimaging in the diagnosis and treatment of intracranial pressure disorders. ⁶²	Moreno ME...Del Carpio-O'Donovan R	36333629	2022
20	The yield of ophthalmoscopy as a screening tool for intracranial pathology in pediatric headache. ⁶²	Kawar RA...Hashavya S	36401633	2022
21	An overview of peripapillary hyperreflective ovoid mass-like structures. ⁶²	Chapman JJ...Gise R	36094020	2022
22	Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease Presenting as Intracranial Hypertension: A Case Report. ⁶²	Chaudhuri JR...Vallam KK	36261298	2022
23	[Bilateral papilledema as presenting sign of neurocysticercosis]. ⁶²	Koman CE...Kouassi FX	35599057	2022
24	Ocular Findings of Cryptococcal Meningitis in Previously Health Adults. ⁶²	Okeagu CU...Williamson PR	36255081	2022
25	The Clinical Profile of Unilateral and Bilateral Optic Disc Swelling in a Tertiary Center in Northern Malaysia. ⁶²	Abdul Aziz AM...Yaakub A	36415408	2022
26	Cerebrospinal Fluid Shunting for Idiopathic Intracranial Hypertension: A Systematic Review, Meta-Analysis, and Implications for a Modern Management Protocol. ⁶²	Salih M...Ogilvy CS	35916578	2022
27	Idiopathic Intracranial Hypertension and Endoscopic Optic Nerve Sheath Fenestration. ⁶²	Kaur N...Chauhan N	36452828	2022
28	De Novo Presentation of Idiopathic Intracranial Hypertension (IIH) Associated With COVID-19 Infection. ⁶²	Sriuoginys S...Jon Hersir E	36147772	2022
29	Comparison of Idiopathic Intracranial Hypertension Patients With and Without Anemia. ⁶²	Sverdlichenko I...Micieli JA	36255106	2022
30	Stenting versus medical treatment for idiopathic intracranial hypertension: a matched-control study. ⁶²	Raynald...Mo D	36202600	2022
31	Transorbital sonography: A non-invasive bedside screening tool for detection of pseudotumor cerebri syndrome. ⁶²	Korsbak JJ...Jensen RH	35469442	2022
32	Clinical and prognostic importance of craniospinal elastance and pressure volume index in pediatric pseudotumor cerebri syndrome. ⁶²	Yucel G	36190524	2022
33	A clinico-radiological study of deep cerebral venous thrombosis. ⁶²	Kalita J...Kumar S	35462575	2022
34	Multimodal imaging of the course of retinal changes in acute posterior multifocal placoid pigment epitheliopathy with bilateral retinal detachment: a case report. ⁶²	Su G...Cai SJ	36207677	2022
35	Ophthalmological Findings in Youths With a Newly Diagnosed Brain Tumor. ⁶²	Nuijts MA...Imhof SM	36107418	2022
36	Peripapillary hyperreflective ovoid masslike structures in a pediatric population referred for suspected papilledema. ⁶²	Eshun EL...Ditta LC	36189468	2022
37	Lupus Anticoagulant-Hypoprothrombinemia Syndrome and Pseudotumor Cerebri as an Initial Presentation of Systemic Lupus Erythematosus in a 16-Year-Old Male Patient: A Case Report and Literature Review. ⁶²	Omer MH...AlJohani G	36207805	2022
38	Endophthalmitis diagnosis supported by bedside ultrasound. ⁶²	Gong JJ...Desmond-Combs K	36176502	2022
39	[FROM OPTIC NERVE EDEMA TO POLYSOMNOGRAPHY - ANOTHER WAY TO DIAGNOSE OBSTRUCTIVE SLEEP APNEA]. ⁶²	Luski S...Kruger JM	36315213	2022
40	Bilateral papilledema associated with retinal hemorrhagic appearance as earliest sign of spinal cord tumor. ⁶²	Giannuzzi F...Rizzo S	36214152	2022
41	Inappropriate Use of the Term "Papilledema" in the Medical Literature: A Systematic Review of Case Reports across Specialties. ⁶²	Tao B...Micieli JA	36195254	2022
42	The use of OCT to detect signs of intracranial hypertension in patients with sagittal suture synostosis: Reference values and correlations. ⁶²	van de Beeten SDC...Mathijssen IMJ	35972534	2022
43	The Spectrum of Ocular Manifestations in Patients with Waldenström's Macroglobulinemia. ⁶²	Dammacco R...Dammacco F	34270382	2022
44	Early and long-term skull growth after surgical correction for sagittal synostosis in relation to the occurrence of papilledema. ⁶²	van de Beeten SDC...van Veelen MC	36053310	2022
45	Discriminating Between Papilledema and Optic Disc Drusen Using 3D Structural Analysis of the Optic Nerve Head. ⁶²	Girard MJ...Milea D	36175153	2022
46	Giant Colloid Cyst. ⁶²	Alkhaibary A...Khairy S	35803569	2022
47	[Ocular symptoms in cerebellitis caused by COVID-19 : Cerebellitis, a less noticed disease with neuro-ophthalmological findings]. ⁶²	Schmidt D	36169716	2022
48	Acute Headache in Adults: A Diagnostic Approach. ⁶²	Viera AJ...Antono B	36126007	2022
49	Ocular Findings in Children with Headache. ⁶²	Lin LY...Binenbaum G	36125107	2022
50	Meningeal Metastasis Causing Chronic Subdural Hematoma in a Cancer Patient with Bilateral Papilledema and Suspected Cerebral Venous Thrombosis: A Case Report. ⁶²	Pangratz-Daller C...Schwartz C	35453161	2022

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Genes for Papilledema

Genes related to Papilledema (0 elite genes):

(show all 21)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	F2	Coagulation Factor II, Thrombin	Protein Coding	13.73	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
2	JAK2	Janus Kinase 2	Protein Coding	11.92	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
3	APOH	Apolipoprotein H	Protein Coding	11.83	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
4	IL1R1	Interleukin 1 Receptor Type 1	Protein Coding	11.24	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
5	TP53	Tumor Protein P53	Protein Coding	11.22	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
6	ARSB	Arylsulfatase B	Protein Coding	10.82	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
7	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	10.74	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
8	CRP	C-Reactive Protein	Protein Coding	6.42	DISEASES inferred ¹⁴
9	SERPINC1	Serpin Family C Member 1	Protein Coding	6.34	DISEASES inferred ¹⁴
10	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	6.05	DISEASES inferred ¹⁴
11	MYOM2	Myomesin 2	Protein Coding	6.04	DISEASES inferred ¹⁴
12	F3	Coagulation Factor III, Tissue Factor	Protein Coding	5.81	DISEASES inferred ¹⁴
13	AQP4	Aquaporin 4	Protein Coding	5.78	DISEASES inferred ¹⁴
14	NLRP3	NLR Family Pyrin Domain Containing 3	Protein Coding	5.75	DISEASES inferred ¹⁴
15	SERPINA3	Serpin Family A Member 3	Protein Coding	5.7	DISEASES inferred ¹⁴ ¹⁴
16	MOG	Myelin Oligodendrocyte Glycoprotein	Protein Coding	5.63	DISEASES inferred ¹⁴
17	SYP	Synaptophysin	Protein Coding	5.61	DISEASES inferred ¹⁴
18	ACE	Angiotensin I Converting Enzyme	Protein Coding	5.59	DISEASES inferred ¹⁴
19	ALB	Albumin	Protein Coding	5.48	DISEASES inferred ¹⁴
20	IL6	Interleukin 6	Protein Coding	5.44	DISEASES inferred ¹⁴
21	CD4	CD4 Molecule	Protein Coding	5.44	DISEASES inferred ¹⁴

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Variations for Papilledema

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Expression for Papilledema

Search GEO for disease gene expression data for Papilledema.

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Pathways for Papilledema

Pathways related to Papilledema according to GeneCards Suite gene sharing:

(show all 29)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.89	ARSB CRP F2 IL1R1 IL6 JAK2
2	Response to elevated platelet cytosolic Ca2+ ⁶⁶ Show member pathways Disinhibition of SNARE formation ⁶⁶ Hemostasis ⁶⁶ Platelet activation, signaling and aggregation ⁶⁶ Platelet degranulation ⁶⁶	12.97	VEGFA TP53 SERPINC1 SERPINA3 JAK2 F3
3	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.49	TP53 STAT3 JAK2 IL6 F2
4	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) ⁶⁶ Show member pathways Post-translational protein phosphorylation ⁶⁶	12.29	SERPINC1 IL6 F2 ALB
5	Toll Comparative Pathway ⁶⁴ Show member pathways IL-1 Pathway ⁶⁴ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶⁴ TLR-TRIF Pathway ⁶⁴	12.24	TP53 JAK2 IL6 IL1R1
6	Colorectal Cancer Metastasis ⁶⁴	12.09	VEGFA TP53 STAT3 IL6
7	Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers ⁶⁵	11.96	ALB IL6 STAT3 VEGFA
8	Spinal cord injury ⁷⁴	11.87	TP53 IL6 IL1R1 AQP4
9	Visual Cycle in Retinal Rods ⁶⁴	11.8	STAT3 SERPINA3 JAK2 CRP
10	CCL18 signaling pathway ⁷⁴	11.74	VEGFA STAT3 JAK2 IL6
11	Activation of NF-KappaB by PKR ⁶⁴ Show member pathways Canonical NF-kB pathway ⁷⁴ Cellular Transformation by HTLV1 ⁶⁴ Inhibition of PKR ⁶⁶ STING pathway in Kawasaki-like disease and COVID-19 ⁷⁴	11.72	NLRP3 JAK2 F3
12	Neural Stem Cells and Lineage-specific Markers ⁶⁵	11.7	VEGFA SYP MOG
13	Th17 Differentiation ⁶⁵ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.69	STAT3 JAK2 IL6 IL1R1
14	Burn wound healing ⁷⁴	11.67	VEGFA TP53 IL6
15	Th17 cell differentiation pathway ⁷⁴	11.63	STAT3 JAK2 IL6
16	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.59	VEGFA TP53 STAT3 JAK2 IL6
17	IL 10 signaling pathway ⁶⁷	11.57	STAT3 JAK2 IL6
18	SHP2 signaling ⁶¹	11.51	VEGFA JAK2 IL6
19	Interleukin-10 signaling ⁶⁶	11.43	STAT3 IL6 IL1R1
20	Hepatitis C and hepatocellular carcinoma ⁷⁴	11.41	IL6 STAT3 TP53 VEGFA
21	Mitochondrial immune response to SARS-CoV-2 ⁷⁴ Show member pathways SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction ⁷⁴	11.31	NLRP3 IL6 ACE
22	IL6-mediated signaling events ⁶¹	11.28	STAT3 JAK2 IL6 CRP
23	Prostaglandin signaling ⁷⁴	11.12	VEGFA NLRP3 IL6
24	IL1 and megakaryocytes in obesity ⁷⁴	11.03	NLRP3 IL1R1 F2
25	Interleukin-6 family signaling ⁶⁶ Show member pathways IL-6-type cytokine receptor ligand interactions ⁶⁶ Immune response Oncostatin M signaling via JAK-Stat in human cells ²² Interleukin-6 signaling ⁶⁶	10.87	VEGFA STAT3 SERPINA3 JAK2 IL6
26	ncRNAs involved in STAT3 signaling in hepatocellular carcinoma ⁷⁴	10.84	STAT3 JAK2 IL6
27	Development_Leptin signaling via JAK/STAT and MAPK cascades ²² Show member pathways phospho-PLA2 pathway ⁶⁶	10.73	VEGFA STAT3 JAK2 CRP
28	Mammary gland development pathway - Involution (Stage 4 of 4) ⁷⁴	10.63	TP53 STAT3
29	Serotonin receptor 2 and STAT3 signaling ⁷⁴	10.17	STAT3 JAK2

Sources

GO Terms for Papilledema

Cellular components related to Papilledema according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.74	VEGFA SERPINC1 SERPINA3 NLRP3 IL6 IL1R1
2	external side of plasma membrane	GO:0009897	9.7	MOG IL1R1 F3 F2 AQP4 ACE

Biological processes related to Papilledema according to GeneCards Suite gene sharing:

(show all 13)

#	Name	GO ID	Score	Top Affiliating Genes
1	inflammatory response	GO:0006954	10.26	CRP IL1R1 IL6 NLRP3 SERPINA3 STAT3
2	positive regulation of receptor signaling pathway via JAK-STAT	GO:0046427	9.99	JAK2 IL6 F2
3	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	9.97	IL6 JAK2 TP53 VEGFA
4	cytokine-mediated signaling pathway	GO:0019221	9.97	STAT3 JAK2 IL6 IL1R1 F3
5	positive regulation of interleukin-1 beta production	GO:0032731	9.86	STAT3 NLRP3 JAK2 IL6
6	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO:0061419	9.83	VEGFA TP53
7	regulation of vascular endothelial growth factor production	GO:0010574	9.8	IL6 AQP4
8	positive regulation of peptidyl-tyrosine autophosphorylation	GO:1900086	9.73	VEGFA ACE
9	negative regulation of primary miRNA processing	GO:2000635	9.71	STAT3 IL6
10	hemostasis	GO:0007599	9.63	SERPINC1 F3 F2
11	interleukin-6-mediated signaling pathway	GO:0070102	9.63	STAT3 JAK2 IL6
12	regulation of blood coagulation	GO:0030193	9.26	SERPINC1 F2 APOH
13	acute-phase response	GO:0006953	9.23	SERPINA3 IL6 F2 CRP