Papilledema disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: PPL021 MIFTS: 48	Papilledema Categories: Eye diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Papilledema

MalaCards integrated aliases for Papilledema:

Name: Papilledema ¹² ⁷⁶ ⁵³ ²⁹ ⁵⁵ ¹⁵ ⁷³

Edema of the Optic Disc ⁵³

Choked Disk ⁵³

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Eye diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the eye and adnexa

Disorders of optic nerve and visual pathways

Other disorders of optic [2nd] nerve and visual pathways

Papilloedema, unspecified

External Ids:

Disease Ontology ¹² DOID:146

ICD10 ³³ H46.0 H47.1 H47.10

ICD9CM ³⁵ 377.0 377.00 377.31

MeSH ⁴⁴ D010211

NCIt ⁵⁰ C3307

SNOMED-CT ⁶⁸ 73221001

UMLS ⁷³ C0030353

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Summaries for Papilledema

NIH Rare Diseases : ⁵³ Papilledema is a condition in which increased pressure in or around the brain (intracranial pressure) causes swelling of the part of the optic nerve inside the eye (optic disc). Symptoms of increased intracranial pressure include headache or nausea and vomiting. Vision problems are not common initially, but may include short flickers of gray vision, blurred or double vision, and decreased field of vision or ability to see colors. Both eyes are usually affected. Papilledema by definition is caused by increased cranial pressure. Diagnosis includes a thorough eye exam by an ophthalmologist. Brain imaging studies (for example CT scan or MRI) are used to find the cause of the increased intracranial pressure. Treatment depends on the cause of the increased pressure but may include medications, surgery and/or weight management.

MalaCards based summary : Papilledema, also known as edema of the optic disc, is related to intracranial hypertension and ischemic optic neuropathy, and has symptoms including edema An important gene associated with Papilledema is TP53 (Tumor Protein P53), and among its related pathways/superpathways is IL1 and megakaryocytes in obesity. The drugs Acetazolamide and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and spinal cord, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : ⁷⁶ Papilledema (or papilloedema) is optic disc swelling that is caused by increased intracranial pressure... more...

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Related Diseases for Papilledema

Diseases related to Papilledema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 194)

#	Related Disease	Score	Top Affiliating Genes
1	intracranial hypertension	32.5	APOH F2
2	ischemic optic neuropathy	30.2	APOH F2
3	intracranial hypertension, idiopathic	30.2	OGG1 PCLO SEMA6B
4	thrombophilia due to thrombin defect	30.2	APOH F2
5	cerebral sinovenous thrombosis	29.8	APOH F2
6	retinal vascular occlusion	29.8	APOH F2
7	hydrocephalus	11.4
8	papilloma of choroid plexus	11.3
9	optic papillitis	11.3
10	colloid cysts of third ventricle	11.0
11	pseudopapilledema	10.3
12	thrombosis	10.3
13	headache	10.2
14	anterior cranial fossa meningioma	10.2	F2 TP53
15	craniosynostosis	10.2
16	spinal cord infarction	10.2	APOH F2
17	sudden sensorineural hearing loss	10.2	APOH F2
18	prothrombin deficiency, congenital	10.2	APOH F2
19	ischemic colitis	10.2	APOH F2
20	sneddon syndrome	10.2	APOH F2
21	livedoid vasculitis	10.2	APOH F2
22	hepatic infarction	10.2	APOH F2
23	squamous cell papilloma	10.2	F2 TP53
24	thrombophlebitis	10.2	APOH F2
25	antithrombin iii deficiency	10.2	APOH F2
26	peripheral vertigo	10.2	APOH F2
27	buerger disease	10.2	APOH F2
28	central retinal vein occlusion	10.2	APOH F2
29	retinal vein occlusion	10.2	APOH F2
30	branch retinal artery occlusion	10.2	APOH F2
31	retinal artery occlusion	10.2	APOH F2
32	portal vein thrombosis	10.2	APOH F2
33	protein s deficiency	10.1	APOH F2
34	placental abruption	10.1	APOH F2
35	infective endocarditis	10.1	APOH F2
36	endocarditis	10.1	APOH F2
37	cholecystitis	10.1	F2 TP53
38	intermittent claudication	10.1	APOH F2
39	cataract	10.1
40	thrombophilia due to activated protein c resistance	10.1	APOH F2
41	barrett's adenocarcinoma	10.1	OGG1 TP53
42	budd-chiari syndrome	10.1	APOH F2
43	neuropathy	10.1
44	streptococcal meningitis	10.1	IL1R1 MYOM2
45	3-methylglutaconic aciduria, type iii	10.1
46	macular retinal edema	10.1
47	meningitis	10.1
48	mature b-cell neoplasm	10.0	MYOM2 TP53
49	antiphospholipid syndrome	10.0	APOH F2
50	malignant hypertension	10.0

Graphical network of the top 20 diseases related to Papilledema:

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Symptoms & Phenotypes for Papilledema

UMLS symptoms related to Papilledema:

edema

GenomeRNAi Phenotypes related to Papilledema according to GeneCards Suite gene sharing:

²⁶ (show all 26)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-102	9.8	PCLO
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-11	9.8	ARSB
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-110	9.8	ARSB
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-115	9.8	IL1R1
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-122	9.8	ARSB F2 IL1R1 PCLO
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-124	9.8	IL1R1
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-126	9.8	ARSB F2
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-133	9.8	F2
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-146	9.8	F2
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-161	9.8	F2
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-164	9.8	PCLO
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-166	9.8	PCLO
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-168	9.8	IL1R1
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-176	9.8	F2
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-183	9.8	IL1R1
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-198	9.8	IL1R1
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-214	9.8	PCLO
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-25	9.8	IL1R1
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-42	9.8	ARSB
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-43	9.8	ARSB F2
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	9.8	PCLO
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-83	9.8	ARSB
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-9	9.8	IL1R1
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-90	9.8	PCLO
25	Increased shRNA abundance (Z-score > 2)	GR00366-A-99	9.8	IL1R1
26	Increased proliferation	GR00094-A	8.96	IL1R1 TP53

MGI Mouse Phenotypes related to Papilledema:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	9.17	ARSB F2 IL1R1 OGG1 PCLO SEMA6B

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Drugs & Therapeutics for Papilledema

Drugs for Papilledema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 105)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Acetazolamide

Approved, Vet_approved

Phase 4,Phase 2,Phase 3

59-66-5

1986

Bevacizumab

Approved, Investigational

Phase 4,Phase 1,Phase 2

216974-75-3

Ranibizumab

Approved

Phase 4,Phase 2

347396-82-1

459903

Lymecycline

Approved, Investigational

Phase 4

992-21-2

5280963

Minocycline

Approved, Investigational

Phase 4

10118-90-8

5281021

Isotretinoin

Approved

Phase 4

4759-48-2

5538 5282379

Doxycycline

Approved, Investigational, Vet_approved

Phase 4

564-25-0

54671203

diuretics

Phase 4,Phase 2,Phase 3

Carbonic Anhydrase Inhibitors

Phase 4,Phase 2,Phase 3

Anticonvulsants

Phase 4,Phase 2,Phase 3

Natriuretic Agents

Phase 4,Phase 2,Phase 3

Immunologic Factors

Phase 4,Phase 1,Phase 2

Angiogenesis Inhibitors

Phase 4,Phase 1,Phase 2

Angiogenesis Modulating Agents

Phase 4,Phase 1,Phase 2

Endothelial Growth Factors

Phase 4

Mitogens

Phase 4

Pharmaceutical Solutions

Phase 4,Not Applicable

Anti-Bacterial Agents

Phase 4,Phase 2,Not Applicable

Anti-Infective Agents

Phase 4,Phase 2

Dermatologic Agents

Phase 4

Naproxen

Approved, Vet_approved

Phase 2, Phase 3

22204-53-1

1302 156391

Aspirin

Approved, Vet_approved

Phase 2, Phase 3,Not Applicable

50-78-2

2244

Codeine

Approved, Illicit

Phase 2, Phase 3

76-57-3

5284371

Guaifenesin

Approved, Investigational, Vet_approved

Phase 2, Phase 3

93-14-1

3516

Acetaminophen

Approved

Phase 2, Phase 3

103-90-2

1983

Ibuprofen

Approved

Phase 2, Phase 3

15687-27-1

3672

Dexamethasone

Approved, Investigational, Vet_approved

Phase 2, Phase 3

50-02-2

5743

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 2, Phase 3

1177-87-3

Warfarin

Approved

Phase 3

81-81-2

6691 54678486

Serine

Approved, Nutraceutical

Phase 3

56-45-1

5951

Anti-Inflammatory Agents

Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable

glucocorticoids

Phase 2, Phase 3,Phase 1

Hormone Antagonists

Phase 2, Phase 3,Phase 1

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 2, Phase 3,Phase 1

Hormones

Phase 2, Phase 3,Phase 1

Analgesics, Non-Narcotic

Phase 2, Phase 3,Not Applicable

Narcotics

Phase 2, Phase 3

Central Nervous System Depressants

Phase 2, Phase 3

Chlorpheniramine, phenylpropanolamine drug combination

Phase 2, Phase 3

Anti-Inflammatory Agents, Non-Steroidal

Phase 2, Phase 3,Not Applicable

Analgesics

Phase 2, Phase 3,Not Applicable

Cyclooxygenase Inhibitors

Phase 2, Phase 3

Respiratory System Agents

Phase 2, Phase 3

Peripheral Nervous System Agents

Phase 2, Phase 3,Phase 3,Not Applicable

Analgesics, Opioid

Phase 2, Phase 3

Antipyretics

Phase 2, Phase 3

Fibrinolytic Agents

Phase 2, Phase 3

Platelet Aggregation Inhibitors

Phase 2, Phase 3

Antirheumatic Agents

Phase 2, Phase 3,Phase 1,Not Applicable

Antitussive Agents

Phase 2, Phase 3

Interventional clinical trials:

(show all 40)

#	Name	Status	NCT ID	Phase	Drugs
1	ALPI vs Medical Therapy Effects on Optic Nerve Structure & Function	Unknown status	NCT00485238	Phase 4	Intravenous acetazolamide
2	Treatment of Diabetic Macular Edema (DME) With Anti-VEGF and Focal Laser	Completed	NCT03590444	Phase 4	Ranibizumab 0.5 MG/0.05 ML Intraocular Solution
3	Pegaptanib for Retinal Edema Secondary to Diabetic Vascular Disease(Preserve) Study	Completed	NCT01486238	Phase 4	Macugen® pegaptanib sodium
4	Antiacne Medications Pseudotumor Cerebri	Recruiting	NCT02149615	Phase 4
5	Idiopathic Intracranial Hypertension Treatment Trial	Completed	NCT01003639	Phase 2, Phase 3	Acetazolamide;Placebo
6	Ozurdex for Macular Edema Post Membrane Peeling	Completed	NCT01273727	Phase 2, Phase 3	Dexamethasone;dexamethasone
7	Surgical Idiopathic Intracranial Hypertension Treatment Trial	Recruiting	NCT03501966	Phase 3	Acetazolamide
8	The Efficacy and Safety of Dabigatran Etexilate for the Treatment of Cerebral Venous Thrombosis	Recruiting	NCT03217448	Phase 3	Dabigatran etexilate;Warfarin
9	Comparison of Intravitreal Bevacizumab and Triamcinolone With Placebo	Unknown status	NCT01330524	Phase 1, Phase 2	Avastin and Triamcinolone
10	Safety and Effectiveness of 11b-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) to Treat Idiopathic Intracranial Hypertension.	Completed	NCT02017444	Phase 2	AZD4017
11	Efficacy of Biweekly Ranibizumab (0.5 mg) for Exudative Macular Degeneration Retinal Edema Refractory to Anti-VEGF	Recruiting	NCT03071055	Phase 2	Ranibizumab Injection [Lucentis]
12	Intravitreal Aflibercept Injection for Radiation Retinopathy Trial	Recruiting	NCT03085784	Phase 2	Aflibercept
13	Ixazomib Citrate, Lenalidomide, and Dexamethasone in Treating Patients With POEMS Syndrome	Recruiting	NCT02921893	Phase 2	Dexamethasone;Ixazomib Citrate;Lenalidomide
14	Anakinra to Treat Patients With Neonatal Onset Multisystem Inflammatory Disease	Terminated	NCT00069329	Phase 1, Phase 2	anakinra
15	Safety Study of Fluconazole in Combination With Flucytosine for the Treatment of Early Cryptococcal Infection	Terminated	NCT01562132	Phase 2	Flucytosine and fluconazole;Fluconazole
16	Endovascular Stenting Treatment for Patients With Internal Jugular Vein Stenosis	Not yet recruiting	NCT03373292	Phase 1
17	aICP in Glaucoma and Papilledema	Unknown status	NCT02410148	Not Applicable
18	Ocular Point of Care Ultrasound (POCUS) to Detect Optic Disc Swelling in Comparison to Ophthalmologic Examination	Unknown status	NCT02992262	Not Applicable
19	OCT Imaging of Papilledema in Pediatric Idiopathic Intracranial Hypertension	Unknown status	NCT02665858	Not Applicable
20	Assessment of Retinal Nerve Fibre Layer by Optical Coherence Tomography in Uveitis Patients With Papilloedema	Completed	NCT01170481
21	Digital Ocular Fundus Photography in the Emergency Department: A New Application for Telemedicine?	Completed	NCT00873613	Not Applicable
22	Vascular Fundus Changes in Patients With High Probability of Chronic Cerebrospinal Venous Insufficiency (CCSVI)	Completed	NCT01356134
23	Prolensa (Bromfenac) 0.07% QD vs. Ilevro (Nepafenac) 0.3% QD for Treatment of Ocular Inflammation Post Cataract Surgery	Completed	NCT01847638	Not Applicable	Prolensa (bromfenac 0.07%);Ilevro (nepafenac 0.3%)
24	Observe the Effectiveness and Safety of Ranibizumab in Real Life Setting	Completed	NCT01318941		Ranibizumab
25	Cerebral Venous Sinus Thrombosis: Re-exploration of Clinical Assessment Scales	Recruiting	NCT03273179
26	Measurement of Optic Nerve Sheath Diameter in Children Without the Increased Intracranial Pressure	Recruiting	NCT03178760
27	Astronaut Vision Issues in a Ground Analog Population: Polycystic Ovary Syndrome	Recruiting	NCT02896452
28	European Increlex® (Mecasermin [rDNA Origin] Injection) Growth Forum Database - IGFD Registry	Recruiting	NCT00903110		Increlex®
29	Venous Sinus Stenting With the River Stent in IIH	Recruiting	NCT03556085	Not Applicable
30	Studies of the Natural History, Pathogenesis, and Outcome of Autoinflammatory Diseases (NOMID / CAPS, DIRA, CANDLE, SAVI, CRMO, Still's Disease, Behcet's Disease, and Other Undifferentiated Autoinflammatory Diseases)	Recruiting	NCT00059748
31	Evaluating Raised Intracranial Pressure Using MR Elastography	Recruiting	NCT03096743	Not Applicable
32	Effectiveness of Multimodal Imaging for the Evaluation of Retinal Oedema And New vesseLs in Diabetic Retinopathy	Recruiting	NCT03490318
33	Korean Registry of Target Organ Damages in Hypertension	Recruiting	NCT01861080
34	Stenting of Venous Sinus Stenosis for Medically Refractory Idiopathic Intracranial Hypertension	Recruiting	NCT02143258	Not Applicable
35	An RCT of Bariatric Surgery vs a Community Weight Loss Programme for the Sustained Treatment of IIH	Active, not recruiting	NCT02124486	Not Applicable
36	Ocular Manifestations in Rheumatic Diseases	Active, not recruiting	NCT03753893
37	A Single-Center Trial of High Frequency Pegaptanib for Rapid Restoration of VEGF Levels in Diabetic Retinal Edema	Available	NCT01487044		Macugen (Pegaptanib Sodium)
38	Operative Procedures vs. Endovascular Neurosurgery for Untreated Pseudotumor Trial	Not yet recruiting	NCT02513914	Not Applicable
39	Quality and Diagnostic Utility of Mydriatic Fundus Plenoptic Photography	Suspended	NCT03037268
40	Disc Edema in Patients With Chronic Kidney Disease	Withdrawn	NCT00769834

Search NIH Clinical Center for Papilledema

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Genetic Tests for Papilledema

Genetic tests related to Papilledema:

#	Genetic test	Affiliating Genes
1	Papilledema ²⁹

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Anatomical Context for Papilledema

MalaCards organs/tissues related to Papilledema:

⁴¹

Eye, Brain, Spinal Cord, Bone, Prostate, Heart, Bone Marrow

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Publications for Papilledema

Articles related to Papilledema:

(show top 50) (show all 541)

#	Title	Authors	Year
1	Papilledema: Point-of-Care Ultrasound Diagnosis in the Emergency Department. ( 29849246 )	Sinnott J.R....Koboldt T.	2018
2	Papilledema in Idiopathic Intracranial Hypertension. ( 29399792 )	Vgontzas A....Burch R.C.	2018
3	Optic Nerve Head and Macular Optical Coherence Tomography Measurements in Papilledema Compared With Pseudopapilledema. ( 29474199 )	Aghsaei Fard M....Subramanian P.S.	2018
4	Bruch's membrane opening on optical coherence tomography in pediatric papilledema and pseudopapilledema. ( 29535052 )	GarcA-a-Montesinos J....Rebolleda G.	2018
5	Chronic papilledema in a child with classical tuberous sclerosis. ( 29283138 )	Jain K.A....Jain A.B.	2018
6	Re: Chang etA al.: Accuracy of diagnostic imaging modalities for classifying pediatric eyes as papilledema versus pseudopapilledema (Ophthalmology. 2017;124:1839-1848). ( 29458838 )	Lecler A....Gillard P.	2018
7	The Translaminar Pressure Gradient: Papilledema after Trabeculectomy Treated with Optic Nerve Sheath Fenestration. ( 29979338 )	Radke P.M....Sires B.S.	2018
8	Young Man With Severe Bilateral Papilledema. ( 29800986 )	Kothari P....Macintosh P.	2018
9	Papilledema revisiting after sinus angioplasty of chronic cerebral venous sinus thrombosis. ( 29676328 )		2018
10	Rapid effect of depletive lumbar puncture on papilledema in intracranial hypertension. ( 29903588 )		2018
11	Five-Year-Old Boy With Behavioral Changes and Papilledema. ( 28991098 )		2018
12	Arteriovenous ratio and papilledema based hybrid decision support system for detection and grading of hypertensive retinopathy. ( 29249337 )		2018
13	Syphilis-Related Eye Disease Presenting as Bilateral Papilledema, Retinal Nerve Fiber Layer Hemorrhage, and Anterior Uveitis in a Penicillin-Allergic Patient. ( 29670780 )		2018
14	Headache and Papilledema in Guillain-BarrAc Syndrome. ( 29374500 )		2018
15	Multisuture Craniosynostosis and Papilledema in Pycnodysostosis: A Paradox? ( 30394969 )	Thomas GPL...Johnson D	2018
16	Headache Characteristics in Children With Pseudotumor Cerebri Syndrome, Elevated Opening Pressure Without Papilledema, and Normal Opening Pressure: A Retrospective Cohort Study. ( 30137653 )	Hamedani AG...Szperka CL	2018
17	Idiopathic Intracranial Hypertension Without Papilledema (IIHWOP) in Chronic Refractory Headache. ( 29997572 )	Favoni V...Cevoli S	2018
18	Metastatic craniocervical hemangiopericytoma presenting with hydrocephalus and papilledema - Case review. ( 30318074 )	Kweh BTS...Tee JW	2018
19	Neuro-Behcet's disease in a case with papilledema and intracranial hypertension as the initial presentation. ( 30374484 )	Kurna SA...Arsan AK	2018
20	Optical coherence tomography angiography in acute unilateral nonarteritic anterior ischemic optic neuropathy: A comparison with the fellow eye and with eyes with papilledema. ( 30038161 )	Gandhi U...Chhablani PP	2018
21	Early Macular Vessel Density Loss in Acute Ischemic Optic Neuropathy Compared to Papilledema: Implications for Pathogenesis. ( 30271677 )	Fard MA...Subramanian PS	2018
22	Bruch's membrane opening on optical coherence tomography in pediatric papilledema and pseudopapilledema. ( 29535053 )	Fard MA	2018
23	Re: Chang et al.: Accuracy of diagnostic imaging modalities for classifying pediatric eyes as papilledema versus pseudopapilledema (Ophthalmology. 2017;124:1839-1848). ( 30143102 )	Garg A...Chen RW	2018
24	Pediatric Papilledema: Review and a Clinical Care Algorithm. ( 30239361 )	Heidary G	2018
25	Masking of Papilledema by Glaucoma. ( 30532370 )	Venugopal NP...Kummararaj G	2018
26	Cerebral Venous Thrombosis: An Uncommon Cause of Papilledema on Bedside Ocular Ultrasound. ( 30538085 )	Arthur J...McIntosh M	2018
27	Re: Re: The Translaminar Pressure Gradient: Papilledema after Trabeculectomy Treated with Optic Nerve Sheath Fenestration. ( 30540674 )	Radke PM...Sires BS	2018
28	Re: Radke et al - The Translaminar Pressure Gradient - Papilledema After Trabeculectomy Treated With Optic Nerve Sheath Fenestration. ( 30540675 )	Fleischman D	2018
29	Decision Support System for Detection of Papilledema through Fundus Retinal Images. ( 28283997 )	Akbar S....Yasin U.U.	2017
30	Unexpected papilledema in a young male with Type 1 diabetes. ( 28781853 )	Paniagua J.A....Velasco F.	2017
31	&quot;Twin Peaks&quot; Papilledema. ( 28126073 )	Nash D.L....Brodsky M.C.	2017
32	Relationship between lamina cribrosa displacement and trans-laminar pressure difference in papilledema. ( 28391369 )	GarcA-a-Montesinos J....Rebolleda G.	2017
33	Factors Influencing the Incidence of Papilledema in Patients with Cerebral Venous Thrombosis. ( 29387676 )	Saadatnia M....Pirhaji Z.	2017
34	Fully automated diagnosis of papilledema through robust extraction of vascular patterns and ocular pathology from fundus photographs. ( 28270999 )	Fatima K.N....Butt W.H.	2017
35	Vestibular Schwannoma Presenting with Bilateral Papilledema Without Hydrocephalus: Case Study. ( 29375948 )	Candanedo C....Spektor S.	2017
36	Optical Coherence Tomography to Differentiate Papilledema from Pseudopapilledema. ( 28819712 )	Rebolleda G....MuA+oz-Negrete F.J.	2017
37	Commentary: The Dilemma of Papilledema in Chiari I Malformation. ( 29272471 )	Smith V....Lin J.	2017
38	Retrospective analysis of translaminar, demographic, and physiologic parameters in relation to papilledema severity. ( 28237144 )	Fleischman D....Chesnutt D.A.	2017
39	Papilledema in children with hydrocephalus: incidence and associated factors. ( 28387641 )	Lee H.J....Kim S.J.	2017
40	Utility of Intracranial Pressure Monitoring for Diagnosis of Idiopathic Intracranial Hypertension in the Absence of Papilledema. ( 29258930 )	Bridges K.J....Raslan A.M.	2017
41	The diagnostic challenge of evaluating papilledema in the pediatric patient. ( 29018749 )	McCafferty B....Lee M.S.	2017
42	Complete Resolution of Papilledema in Syndromic Craniosynostosis with Posterior Cranial Vault Distraction. ( 28904587 )	Lopresti M....Lam S.	2017
43	Clinical Reasoning: A 57-year-old man with unilateral anosmia, papilledema, and meningismus. ( 28827465 )	Bradshaw M.J....Longmuir R.	2017
44	Sildenafil-related cerebral venous sinus thrombosis and papilledema: a case report of a rare entity. ( 28474148 )	Karti D.T....Celebisoy N.	2017
45	Accuracy of Diagnostic Imaging Modalities for Classifying Pediatric Eyes as Papilledema Versus Pseudopapilledema. ( 28732589 )		2017
46	Accuracy of crescent sign on ocular ultrasound in diagnosing papilledema. ( 29026691 )		2017
47	Bruch's membrane opening on optical coherence tomography in pediatric papilledema and pseudopapilledema. ( 29203329 )		2017
48	Papilledema: A Comprehensive Assessment. ( 29204042 )		2017
49	Myhre syndrome with novel findings: bilateral congenital cortical cataract, bilateral papilledema, accessory nipple, and adenoid hypertrophy. ( 28562390 )		2017
50	Orbital Hydatid Cyst Causing Papilledema and Proptosis in an Adult. ( 28323190 )		2017

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Genes for Papilledema

Genes related to Papilledema (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TP53	Tumor Protein P53	Protein Coding	20.56	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
2	F2	Coagulation Factor II, Thrombin	Protein Coding	20.17	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	APOH	Apolipoprotein H	Protein Coding	16.77	GeneCards inferred via : Publications (show sections)
4	IL1R1	Interleukin 1 Receptor Type 1	Protein Coding	16.77	GeneCards inferred via : Publications (show sections)
5	ARSB	Arylsulfatase B	Protein Coding	16.77	GeneCards inferred via : Publications (show sections)
6	OGG1	8-Oxoguanine DNA Glycosylase	Protein Coding	16.41	DISEASES inferred ¹⁵
7	MYOM2	Myomesin 2	Protein Coding	16.17	DISEASES inferred ¹⁵
8	PCLO	Piccolo Presynaptic Cytomatrix Protein	Protein Coding	15.94	DISEASES inferred ¹⁵
9	SEMA6B	Semaphorin 6B	Protein Coding	15.21	DISEASES inferred ¹⁵

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Variations for Papilledema

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Expression for Papilledema

Search GEO for disease gene expression data for Papilledema.

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Pathways for Papilledema

Pathways related to Papilledema according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	IL1 and megakaryocytes in obesity ¹	10.02	F2 IL1R1

Sources

GO Terms for Papilledema

Biological processes related to Papilledema according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleotide-excision repair	GO:0006289	9.4	OGG1 TP53
2	base-excision repair	GO:0006284	9.37	OGG1 TP53
3	positive regulation of reactive oxygen species metabolic process	GO:2000379	9.32	F2 TP53
4	blood coagulation, intrinsic pathway	GO:0007597	9.26	APOH F2
5	positive regulation of blood coagulation	GO:0030194	9.16	APOH F2
6	regulation of blood coagulation	GO:0030193	8.96	APOH F2
7	negative regulation of fibrinolysis	GO:0051918	8.62	APOH F2

Sources

Sources for Papilledema

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia