CPP
MCID: PPL058
MIFTS: 54

Papilloma of Choroid Plexus (CPP)

Categories: Cancer diseases, Cardiovascular diseases, Eye diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Papilloma of Choroid Plexus

MalaCards integrated aliases for Papilloma of Choroid Plexus:

Name: Papilloma of Choroid Plexus 57 73 20 58 72
Choroid Plexus Papilloma 57 12 20 58 72 36 29 13 6 15 39 17 70
Cpp 57 58 72
Childhood Choroid Plexus Papilloma 12 70
Choroid Plexus Carcinoma 58 70
Papilloma, Choroid Plexus 44
Papilloma Choroid Plexus 54

Characteristics:

Orphanet epidemiological data:

58
papilloma of choroid plexus
Age of onset: All ages;
choroid plexus carcinoma
Inheritance: Autosomal dominant; Prevalence: <1/1000000 (Europe),1-9/1000000 (Europe); Age of onset: Childhood;

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
autosomal dominant


HPO:

31
papilloma of choroid plexus:
Inheritance autosomal dominant inheritance


Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:2626
OMIM® 57 260500
KEGG 36 H01007
MeSH 44 D020288
NCIt 50 C3698 C5800
SNOMED-CT 67 18021007
MESH via Orphanet 45 D020288
ICD10 via Orphanet 33 C71.7 D33.0
UMLS via Orphanet 71 C0205770 C0431109
UMLS 70 C0205770 C0431109 C1332963

Summaries for Papilloma of Choroid Plexus

GARD : 20 Choroid plexus papilloma (CPP) ia a non-cancerous (benign) tumor of the choroid plexus, a network of blood vessels in the brain which surrounds the ventricles and produces the fluid surrounding the brain and spinal cord (cerebrospinal fluid, or CSF). CPPs most commonly occur in children but may occur in adults. Symptoms are generally due to increased secretion of CSF by tumor cells, causing hydrocephalus and subsequent intracranial pressure. Affected individuals may experience headaches, nausea and vomiting, drowsiness, ocular or gaze palsies, optic nerve swelling (papilledema), visual disturbances, and possible blindness. Infants, especially those with a tumor in the third ventricle, can present with hydrocephalus or macrocephaly. Some cases of CPP may result from a mutation in the TP53 gene. Complete tumor removal often cures the condition and may also relieve the hydrocephalus.

MalaCards based summary : Papilloma of Choroid Plexus, also known as choroid plexus papilloma, is related to rhabdoid tumor predisposition syndrome 1 and atypical choroid plexus papilloma, and has symptoms including seizures, vomiting and headache. An important gene associated with Papilloma of Choroid Plexus is TP53 (Tumor Protein P53), and among its related pathways/superpathways are MAPK signaling pathway and Cell cycle. The drugs Methotrexate and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and eye, and related phenotypes are hydrocephalus and choroid plexus papilloma

OMIM® : 57 Choroid plexus tumors are of neuroectodermal origin and range from benign choroid plexus papillomas (CPPs) to malignant choroid carcinomas (CPCs). These rare tumors generally occur in childhood, but have also been reported in adults. Patients typically present with signs and symptoms of increased intracranial pressure including headache, hydrocephalus, papilledema, nausea, vomiting, cranial nerve deficits, gait impairment, and seizures (summary by Safaee et al., 2013). (260500) (Updated 05-Apr-2021)

KEGG : 36 Choroid plexus tumors (CPTs) are rare intraventricular papillary neoplasms of neuroectodermal origin, accounting for less than 1% of all intracranial tumors and 2-4% of pediatric brain tumors. CPTs are categorized by three distinct histologies; choroid plexus papilloma, atypical choroid plexus papilloma, and the malignant choroid plexus carcinoma. Choroid plexus papillomas outnumber choroid plexus carcinomas and are composed of a single layer of cuboidal-to-columnar cells, resting on a basement membrane overlying papillary and vascularized connective tissue.

UniProtKB/Swiss-Prot : 72 Papilloma of choroid plexus: A benign tumor of neuroectodermal origin that generally occurs in childhood, but has also been reported in adults. Although generally found within the ventricular system, choroid plexus papillomas can arise ectopically in the brain parenchyma or disseminate throughout the neuraxis. Patients present with signs and symptoms of increased intracranial pressure including headache, hydrocephalus, papilledema, nausea, vomiting, cranial nerve deficits, gait impairment, and seizures.

Wikipedia : 73 Choroid plexus papilloma, also known as papilloma of the choroid plexus, is a rare benign... more...

Related Diseases for Papilloma of Choroid Plexus

Diseases related to Papilloma of Choroid Plexus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 601)
# Related Disease Score Top Affiliating Genes
1 rhabdoid tumor predisposition syndrome 1 32.5 TP53 SMARCB1
2 atypical choroid plexus papilloma 32.0 KCNJ13 CCDC47 ACP3
3 obstructive hydrocephalus 31.2 SYP GFAP ENO2
4 choroid plexus cancer 30.9 TTR TP53 SYP SMARCB1 KCNJ13 GFAP
5 head injury 30.9 S100B ENO2
6 cellular ependymoma 30.9 SYP S100B MUC1 LINC01194 GFAP
7 papillary ependymoma 30.8 TTR SYP S100B GFAP
8 pleuropulmonary blastoma 30.7 TP53 S100B IGF2
9 chiari malformation 30.6 SYP GFAP
10 secretory meningioma 30.6 SMARCB1 MUC1 KRT7
11 traumatic brain injury 30.5 S100B GFAP ENO2
12 brain injury 30.5 S100B GFAP ENO2
13 giant cell glioblastoma 30.5 TP53 SYP GFAP
14 akinetic mutism 30.4 S100B ENO2
15 li-fraumeni syndrome 30.4 TP53 SMARCB1 IGF2
16 cerebellar medulloblastoma 30.3 SYP GFAP ENO2
17 adrenal cortical carcinoma 30.3 TP53 SYP MUC1 IGF2
18 central neurocytoma 30.3 SYP GFAP ENO2
19 hemangioblastoma 30.3 SYP S100B MUC1 GFAP ENO2
20 dermatofibrosarcoma protuberans 30.3 TP53 S100B ENO2
21 meningioma, familial 30.3 TP53 SYP SMARCB1 S100B MUC1 IGF2
22 neurofibroma 30.2 TP53 SYP S100B MUC1
23 myxopapillary ependymoma 30.2 SYP S100B MUC1 GFAP
24 central nervous system cancer 30.2 TP53 SYP SMARCB1 GFAP
25 rhabdoid cancer 30.2 TP53 SYP SMARCB1 MUC1 IGF2
26 pilocytic astrocytoma 30.2 TP53 SYP S100B GFAP
27 anaplastic ependymoma 30.1 SYP S100B MUC1 GFAP
28 oligodendroglioma 30.1 TP53 SYP S100B GFAP ENO2
29 gliosarcoma 30.0 TP53 S100B GFAP ENO2
30 neurilemmoma 30.0 SMARCB1 S100B MUC1 GFAP ENO2
31 neuroma 30.0 SMARCB1 S100B MUC1 GFAP ENO2
32 ependymoblastoma 29.9 SYP SMARCB1 GFAP ENO2
33 oncocytoma 29.9 SYP MUC1 KRT7
34 papillary carcinoma 29.9 SYP MUC1 KRT7
35 papillary adenocarcinoma 29.9 TP53 MUC1 KRT7
36 cystic teratoma 29.9 TP53 SYP KRT7 GFAP ENO2
37 ewing sarcoma 29.8 TP53 SYP S100B IGF2 ENO2
38 mature teratoma 29.7 TP53 SYP KRT7 ENO2
39 rhabdoid meningioma 29.7 SYP SMARCB1 KCNJ13 GFAP ENO2
40 teratoma 29.7 TP53 SYP SMARCB1 KRT7 GFAP ENO2
41 atypical teratoid rhabdoid tumor 29.6 TP53 SYP SMARCB1 S100B MUC1 IGF2
42 medulloblastoma 29.5 TP53 SYP SMARCB1 S100B LINC01194 IGF2
43 intrahepatic cholangiocarcinoma 29.5 TP53 MUC1 KRT7
44 hydrocephalus 29.5 TTR TP53 SYP SMARCB1 S100B GFAP
45 benign teratoma 29.4 TP53 SYP MUC1 KRT7 ENO2
46 adenoma 29.4 TP53 SYP MUC1 KRT7
47 breast adenocarcinoma 29.2 TP53 SYP KRT7 ENO2
48 rhabdomyosarcoma 28.6 TP53 SYP SMARCB1 S100B KRT7 IGF2
49 rhabdoid tumor predisposition syndrome 2 11.2
50 central precocious puberty 11.1

Graphical network of the top 20 diseases related to Papilloma of Choroid Plexus:



Diseases related to Papilloma of Choroid Plexus

Symptoms & Phenotypes for Papilloma of Choroid Plexus

Human phenotypes related to Papilloma of Choroid Plexus:

58 31 (show all 14)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hydrocephalus 58 31 hallmark (90%) Very frequent (99-80%) HP:0000238
2 choroid plexus papilloma 58 31 hallmark (90%) Very frequent (99-80%) HP:0200022
3 visual impairment 58 31 occasional (7.5%) Occasional (29-5%) HP:0000505
4 hypertonia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001276
5 cognitive impairment 58 31 occasional (7.5%) Occasional (29-5%) HP:0100543
6 hemiplegia/hemiparesis 58 31 occasional (7.5%) Occasional (29-5%) HP:0004374
7 seizure 31 occasional (7.5%) HP:0001250
8 seizures 58 Occasional (29-5%)
9 vomiting 31 HP:0002013
10 neoplasm 58 Occasional (29-5%)
11 abnormality of nervous system morphology 58 Very frequent (99-80%)
12 headache 31 HP:0002315
13 papilledema 31 HP:0001085
14 nausea 31 HP:0002018

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
Neurologic Central Nervous System:
seizures
hydrocephalus
headache
intraventricular choroid plexus papilloma
cranial nerve deficits
more
Head And Neck Eyes:
papilledema

Abdomen Gastrointestinal:
vomiting
nausea

Neoplasia:
malignant transformation of choroid plexus papilloma

Clinical features from OMIM®:

260500 (Updated 05-Apr-2021)

UMLS symptoms related to Papilloma of Choroid Plexus:


seizures; vomiting; headache; nausea

GenomeRNAi Phenotypes related to Papilloma of Choroid Plexus according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 SMARCB1 TP53

Drugs & Therapeutics for Papilloma of Choroid Plexus

Drugs for Papilloma of Choroid Plexus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
2
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
3
Topotecan Approved, Investigational Phase 2 123948-87-8, 119413-54-6 60700
4
Levoleucovorin Approved, Investigational Phase 2 68538-85-2 149436
5
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
6
Etoposide Approved Phase 2 33419-42-0 36462
7
Vinblastine Approved Phase 2 865-21-4 241903 13342
8
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
9
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
10
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
11 Tubulin Modulators Phase 2
12 Alkylating Agents Phase 2
13 Folic Acid Antagonists Phase 2
14 Vitamin B9 Phase 2
15 topoisomerase I inhibitors Phase 2
16 Etoposide phosphate Phase 2
17 Immunosuppressive Agents Phase 2
18 Antirheumatic Agents Phase 2
19 Immunologic Factors Phase 2
20 Vitamin B Complex Phase 2
21
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
22 Antimetabolites Phase 2
23 Antimitotic Agents Phase 2
24 Protein Kinase Inhibitors Phase 2
25 Dermatologic Agents Phase 2
26 Folate Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Risk-Adapted Therapy for Young Children With Embryonal Brain Tumors, Choroid Plexus Carcinoma, High Grade Glioma or Ependymoma Active, not recruiting NCT00602667 Phase 2 Induction Chemotherapy;Low-Risk Therapy;High-Risk Therapy;Intermediate-Risk Therapy
2 Molecular and Histopathologic Characterization of Atypical Teratoid Rhabdoid Tumors, Choroid Plexus Carcinomas, Ependymomas, Medulloblastoma HGNET, CNS Embryonal Tumors and Gliomas of the Pediatric CNS Recruiting NCT00897286

Search NIH Clinical Center for Papilloma of Choroid Plexus

Cochrane evidence based reviews: papilloma, choroid plexus

Genetic Tests for Papilloma of Choroid Plexus

Genetic tests related to Papilloma of Choroid Plexus:

# Genetic test Affiliating Genes
1 Choroid Plexus Papilloma 29 TP53

Anatomical Context for Papilloma of Choroid Plexus

MalaCards organs/tissues related to Papilloma of Choroid Plexus:

40
Brain, Spinal Cord, Eye, Pineal, Bone, Ovary, T Cells

Publications for Papilloma of Choroid Plexus

Articles related to Papilloma of Choroid Plexus:

(show top 50) (show all 715)
# Title Authors PMID Year
1
Investigations on a clinically and functionally unusual and novel germline p53 mutation. 6 57 61
12085209 2002
2
Identification of a novel TP53 germline mutation E285V in a rare case of paediatric adrenocortical carcinoma and choroid plexus carcinoma. 57 6
18762572 2008
3
Choroid plexus papillomas: advances in molecular biology and understanding of tumorigenesis. 61 57
23172371 2013
4
Spectrum of hSNF5/INI1 somatic mutations in human cancer and genotype-phenotype correlations. 57
10556283 1999
5
Familial occurrence of tumours of the choroid plexus. 57
1895322 1991
6
Choroid plexus carcinoma in siblings: a study by light and electron microscopy with Ki-67 immunocytochemistry. 57
2732756 1989
7
[Familial intraventricular papilloma. Angiographic characteristics]. 57
5842429 1965
8
Choroid plexus papilloma with stromal deposition of amyloid and elastic material. 61 54
20462365 2010
9
Identification of novel diagnostic markers for choroid plexus tumors: a microarray-based approach. 54 61
16330944 2006
10
Histological spectrum of ependymomas and correlation of p53 and Ki-67 expression with ependymoma grade and subtype. 54 61
15318011 2004
11
Expression of the simian virus 40 large tumor antigen (Tag) and formation of Tag-p53 and Tag-pRb complexes in human brain tumors. 61 54
10570441 1999
12
Immunohistochemical study of insulin-like growth factor II (IGF-II) and insulin-like growth factor binding protein-2 (IGFBP-2) in choroid plexus papilloma. 54 61
10406004 1999
13
Immunocytochemical detection of insulin-like growth factor II (IGF-II) in choroid plexus papilloma: a possible marker for differential diagnosis. 61 54
10192701 1999
14
Primary choroid plexus papilloma located in the suprasellar region: case report. 61 54
1383866 1992
15
[Immunohistochemical study for choroid plexus papillomas and ependymomas]. 61 54
1726244 1991
16
Intra-fourth-ventricular choroid plexus papilloma miming ependymoma. 61
33763674 2021
17
Pediatric choroid plexus papilloma arising from the cerebellopontine angle: systematic review with illustrative case. 61
32980905 2021
18
Management of choroid plexus tumours: A comprehensive study from a tertiary hospital. 61
33444945 2021
19
Molecular insights into malignant progression of atypical choroid plexus papilloma. 61
33608379 2021
20
Surgical management of choroid plexus papilloma of the cerebellopontine and cerebellomedullary angle: classification and strategy. 61
33629235 2021
21
Synchronous choroid plexus papilloma and Wilms tumor in a girl, disclosing a Li-Fraumeni syndrome. 61
33407742 2021
22
The radiotherapy utilization rate in pediatric tumors: An analysis of 13,305 patients. 61
33039421 2021
23
CSF Rhinorrhea: A Rare Clinical Presentation of Choroid Plexus Papilloma. 61
33572678 2021
24
Pediatric atypical choroid plexus papilloma: Clinical features and diagnosis. 61
33203591 2021
25
Echovirus-30 Infection Alters Host Proteins in Lipid Rafts at the Cerebrospinal Fluid Barrier In Vitro. 61
33321840 2020
26
The genetic landscape of choroid plexus tumors in children and adults. 61
33249490 2020
27
Evaluation of RAPNO criteria in medulloblastoma and other leptomeningeal seeding tumors using MRI and clinical data. 61
32215549 2020
28
Incidental Findings on Brain Magnetic Resonance Imaging (MRI) in Pediatric Endocrine Patients. 61
33471712 2020
29
Localization of ZIP14 and ZIP8 in HIBCPP Cells. 61
32784388 2020
30
Primary papillary epithelial tumour of the sella: expanding the spectrum of TTF-1-positive sellar lesions. 61
32311761 2020
31
Infratentorial choroid plexus tumors in children. 61
32123998 2020
32
Polar Infection of Echovirus-30 Causes Differential Barrier Affection and Gene Regulation at the Blood-Cerebrospinal Fluid Barrier. 61
32872518 2020
33
A Rare Case of Choroid Plexus Papilloma of the Third Ventricle in an Adult. 61
32923188 2020
34
Bevacizumab in progressive disseminated atypical choroid plexus papilloma in adults. 61
32249894 2020
35
Extracerebral choroid plexus papilloma in the pharynx with airway obstruction in a newborn: a case report. 61
32635904 2020
36
Shunt Ascites in a Fourth Ventricular Choroid Plexus Papilloma in a Young Child: An Uncommon Case. 61
33531966 2020
37
Moderate-to-strong expression of FGFR3 and TP53 alterations in a subpopulation of choroid plexus tumors. 61
31660579 2020
38
INCIDENTAL FINDINGS ON BRAIN MAGNETIC RESONANCE IMAGING (MRI) IN PEDIATRIC ENDOCRINE PATIENTS. 61
32576030 2020
39
Epigenetics impacts upon prognosis and clinical management of choroid plexus tumors. 61
32342334 2020
40
Third ventricle choroid plexus papilloma: 2 cases. 61
32123552 2020
41
Choroid plexus papilloma of the third ventricle. A case report. 61
31401052 2020
42
The first pancreatic neuroendocrine tumor in Li-Fraumeni syndrome: a case report. 61
32228502 2020
43
RBL1 (p107) functions as tumor suppressor in glioblastoma and small-cell pancreatic neuroendocrine carcinoma in Xenopus tropicalis. 61
32001819 2020
44
Multiple Sclerosis and the Choroid Plexus: Emerging Concepts of Disease Immunopathophysiology. 61
31780202 2020
45
The Choroid Plexus Is Permissive for a Preactivated Antigen-Experienced Memory B-Cell Subset in Multiple Sclerosis. 61
33574821 2020
46
Hemifacial Spasm Associated with Compression of the Facial Colliculus by a Choroid Plexus Papilloma of the Fourth Ventricle. 61
32316018 2020
47
Maxillary mesenchymal chondrosarcoma leading to a diagnosis of Li-Fraumeni syndrome. 61
31976063 2020
48
Choroid plexus papilloma in extragonadal teratoma with predominantly neurogenic elements: a case report and review of the literature. 61
32558431 2020
49
Choroid plexus papilloma in extragonadal teratoma with predominantly neurogenic elements: a case report and review of the literature. 61
32558433 2020
50
Role of available adjuvant therapies following surgical resection of atypical choroid plexus papilloma-a systematic review and pooled analysis. 61
33305270 2020

Variations for Papilloma of Choroid Plexus

ClinVar genetic disease variations for Papilloma of Choroid Plexus:

6 (show all 16)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 NF2 NM_000268.4(NF2):c.575A>G (p.Tyr192Cys) SNV other 438777 rs1555993319 GRCh37: 22:30051641-30051641
GRCh38: 22:29655652-29655652
2 FOXO3 NM_001455.4(FOXO3):c.583A>T (p.Lys195Ter) SNV other 438763 rs1554209779 GRCh37: 6:108882994-108882994
GRCh38: 6:108561791-108561791
3 NSD1 NM_022455.4(NSD1):c.7147G>T (p.Gly2383Cys) SNV other 438779 rs1554207664 GRCh37: 5:176721516-176721516
GRCh38: 5:177294515-177294515
4 TP53 NM_000546.5(TP53):c.96+1G>T SNV Pathogenic 482212 rs1131691003 GRCh37: 17:7579699-7579699
GRCh38: 17:7676381-7676381
5 TP53 NM_000546.6(TP53):c.524G>A (p.Arg175His) SNV Pathogenic 12374 rs28934578 GRCh37: 17:7578406-7578406
GRCh38: 17:7675088-7675088
6 TP53 NM_000546.5(TP53):c.559+1G>A SNV Pathogenic 428908 rs1131691042 GRCh37: 17:7578370-7578370
GRCh38: 17:7675052-7675052
7 TP53 NM_001276697.2(TP53):c.-3_4dup (p.Ala2fs) Duplication Pathogenic 12380 rs863223301 GRCh37: 17:7578448-7578449
GRCh38: 17:7675130-7675131
8 TP53 NM_000546.5(TP53):c.854A>T (p.Glu285Val) SNV Pathogenic 12384 rs121912667 GRCh37: 17:7577084-7577084
GRCh38: 17:7673766-7673766
9 TP53 NM_000546.6(TP53):c.818G>A (p.Arg273His) SNV Pathogenic 12366 rs28934576 GRCh37: 17:7577120-7577120
GRCh38: 17:7673802-7673802
10 TP53 NM_000546.6(TP53):c.743G>A (p.Arg248Gln) SNV Pathogenic 12356 rs11540652 GRCh37: 17:7577538-7577538
GRCh38: 17:7674220-7674220
11 TP53 NM_000546.6(TP53):c.742C>T (p.Arg248Trp) SNV Pathogenic 12347 rs121912651 GRCh37: 17:7577539-7577539
GRCh38: 17:7674221-7674221
12 TP53 NM_000546.5(TP53):c.799C>T (p.Arg267Trp) SNV Likely pathogenic 141764 rs55832599 GRCh37: 17:7577139-7577139
GRCh38: 17:7673821-7673821
13 TP53 NM_000546.5(TP53):c.760A>G (p.Ile254Val) SNV Uncertain significance 406605 rs746601313 GRCh37: 17:7577521-7577521
GRCh38: 17:7674203-7674203
14 TP53 NM_000546.5(TP53):c.466C>T (p.Arg156Cys) SNV Uncertain significance 127810 rs563378859 GRCh37: 17:7578464-7578464
GRCh38: 17:7675146-7675146
15 TP53 NM_000546.5(TP53):c.461G>A (p.Gly154Asp) SNV Uncertain significance 237950 rs762846821 GRCh37: 17:7578469-7578469
GRCh38: 17:7675151-7675151
16 TP53 NM_000546.6(TP53):c.847C>T (p.Arg283Cys) SNV Uncertain significance 127824 rs149633775 GRCh37: 17:7577091-7577091
GRCh38: 17:7673773-7673773

Expression for Papilloma of Choroid Plexus

Search GEO for disease gene expression data for Papilloma of Choroid Plexus.

Pathways for Papilloma of Choroid Plexus

Pathways related to Papilloma of Choroid Plexus according to KEGG:

36
# Name Kegg Source Accession
1 MAPK signaling pathway hsa04010
2 Cell cycle hsa04110
3 p53 signaling pathway hsa04115
4 Apoptosis hsa04210
5 Wnt signaling pathway hsa04310
6 Neurotrophin signaling pathway hsa04722
7 Pathways in cancer hsa05200

Pathways related to Papilloma of Choroid Plexus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 SYP S100B GFAP ENO2
2 10.7 SYP S100B GFAP

GO Terms for Papilloma of Choroid Plexus

Biological processes related to Papilloma of Choroid Plexus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.32 TP53 MUC1
2 ER overload response GO:0006983 9.26 TP53 CCDC47
3 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003 9.16 TP53 MUC1
4 purine nucleobase metabolic process GO:0006144 8.96 TTR ACP3
5 positive regulation of histone H4 acetylation GO:0090240 8.62 SMARCB1 MUC1

Molecular functions related to Papilloma of Choroid Plexus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 p53 binding GO:0002039 8.8 TP53 SMARCB1 MUC1

Sources for Papilloma of Choroid Plexus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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