Papillomatosis, Confluent and Reticulated (CARP)

Categories: Genetic diseases, Skin diseases

Aliases & Classifications for Papillomatosis, Confluent and Reticulated

MalaCards integrated aliases for Papillomatosis, Confluent and Reticulated:

Name: Papillomatosis, Confluent and Reticulated 56
Papillomatosis, Reticulated and Confluent, of Gougerot and Carteaud 56
Papillomatosis, Familial Cutaneous 56
Carp 56



autosomal dominant

onset in teenage or young adult years
mode of inheritance is unclear
favorable response to treatment with minocycline or azithromycin


papillomatosis, confluent and reticulated:
Inheritance autosomal dominant inheritance


External Ids:

OMIM 56 167900
MedGen 41 C0263385

Summaries for Papillomatosis, Confluent and Reticulated

OMIM : 56 Confluent and reticulated papillomatosis is a dermatologic disorder characterized by onset in the teenage or young adult years of hyperkeratotic 1- to 2-mm papules that increase in size to 4 to 5 mm and coalesce to form a reticular pattern peripherally and a confluent pattern centrally. Early papules can be erythematous and later turn brown. Affected individuals are usually otherwise asymptomatic. The condition is distinct from acanthosis nigricans and tinea versicolor (infection with the yeast Pityrosporum), but can appear similar. Microscopic examination of skin biopsy shows epidermal undulation with hyperkeratosis, squat papillomatosis, and occasional acanthotic downward projections from the bases of the dells between papillomatous areas. Antibacterial agents such as minocycline and azithromycin are effective, perhaps due to their antiinflammatory and immunomodulatory properties (summary by Scheinfeld, 2006). (167900)

MalaCards based summary : Papillomatosis, Confluent and Reticulated, also known as papillomatosis, reticulated and confluent, of gougerot and carteaud, is related to carp allergy and kleefstra syndrome 1. The drugs Immunologic Factors and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include retina, liver and brain, and related phenotype is hyperkeratosis.

Wikipedia : 74 Confluent and reticulated papillomatosis of Gougerot and Carteaud is an uncommon but distinctive... more...

Related Diseases for Papillomatosis, Confluent and Reticulated

Diseases related to Papillomatosis, Confluent and Reticulated via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 255)
# Related Disease Score Top Affiliating Genes
1 carp allergy 12.3
2 kleefstra syndrome 1 11.4
3 cornelia de lange syndrome 1 11.2
4 acromelic frontonasal dysostosis 11.2
5 collins pope syndrome 11.2
6 papilloma 10.9
7 hemorrhagic disease 10.7
8 myxozoa 10.6
9 anoxia 10.6
10 hydrops, lactic acidosis, and sideroblastic anemia 10.4
11 polyploidy 10.4
12 b-cell lymphoma 10.4
13 hypoxia 10.4
14 bacterial infectious disease 10.3
15 cytokine deficiency 10.3
16 insulin-like growth factor i 10.3
17 kidney disease 10.3
18 acute kidney failure 10.3
19 47,xyy 10.3
20 48,xyyy 10.3
21 helix syndrome 10.3
22 rapidly involuting congenital hemangioma 10.3
23 pseudoatrophoderma colli 10.2
24 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.2
25 paragangliomas 3 10.2
26 ectodermal dysplasia-syndactyly syndrome 2 10.2
27 stomatitis 10.2
28 dermatitis 10.2
29 polykaryocytosis inducer 10.2
30 interstitial nephritis 10.2
31 peritonitis 10.2
32 hyperglycemia 10.2
33 posttransplant acute limbic encephalitis 10.2
34 metabolic acidosis 10.1
35 lymphopenia 10.1
36 triiodothyronine receptor auxiliary protein 10.1
37 erysipelas 10.1
38 coccidiosis 10.1
39 skin disease 10.1
40 dentinogenesis imperfecta type 2 10.1
41 tetraploidy 10.1
42 triploidy 10.1
43 arteries, anomalies of 10.0
44 atrial standstill 1 10.0
45 ataxia and polyneuropathy, adult-onset 10.0
46 riboflavin deficiency 10.0
47 hyperlipoproteinemia, type iii 10.0
48 angiosarcoma 10.0
49 rabies 10.0
50 chlamydia 10.0

Graphical network of the top 20 diseases related to Papillomatosis, Confluent and Reticulated:

Diseases related to Papillomatosis, Confluent and Reticulated

Symptoms & Phenotypes for Papillomatosis, Confluent and Reticulated

Human phenotypes related to Papillomatosis, Confluent and Reticulated:

# Description HPO Frequency HPO Source Accession
1 hyperkeratosis 31 HP:0000962

Symptoms via clinical synopsis from OMIM:

Skin Nails Hair Skin Histology:
epidermal undulation
squat papillomatosis
acanthotic downward projections from areas between the papillae

Skin Nails Hair Skin Electron Microscopy:
increased number of transitional cells between the stratum granulosum and stratum corneum

Skin Nails Hair Skin:
papillomatosis, reticular on the periphery, 1 to 2-mm growing to 4-5-mm and coalescing
papillomatosis, confluent centrally, erythematous turning brown later
scaly rash

Clinical features from OMIM:


Drugs & Therapeutics for Papillomatosis, Confluent and Reticulated

Drugs for Papillomatosis, Confluent and Reticulated (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 2
2 Pharmaceutical Solutions Phase 2
3 Cola Phase 1
Benzoyl peroxide Approved 94-36-0 7187
5 Immunoglobulins
6 Antibodies
7 Anti-Bacterial Agents
8 Antibiotics, Antitubercular
9 Anti-Infective Agents

Interventional clinical trials:

# Name Status NCT ID Phase Drugs
1 A Multinational Phase IIb Study to Investigate the Efficacy and Safety of Subcutaneous Immunotherapy With a Modified Fish- Parvalbumin Given in Single Rising and Maintenance Doses to Subjects Allergic to Fish Completed NCT02382718 Phase 2
2 Safety Study of Compression Anastomotic Ring-locking Procedure (CARP) in Patients Undergoing Colonic Resection Completed NCT01451008 Phase 1
3 Clinical Follow-up of Anti-Carbamylated Antibody Status in Rheumatoid Arthritis Patients at 6, 12 and 18 Months Unknown status NCT02958319
4 Diagnostic Value of Antibodies Against Carbamylated Proteins in Psoriatic Arthritis. Completed NCT04173039
5 CSP #411 - The Coronary Artery Revascularization Prophylaxis (CARP) Trial Completed NCT00032370
6 Allergy Against Different Species of Fish in Children and Adolescents Allergic to Fish Completed NCT02365168
7 Hyperbaric Oxygen Therapy for Antibiotic Refractory Pouchitis: a Phase 2A Clinical Trial Not yet recruiting NCT03526796
8 Electrophysiological Correlates of Cognition in Depression Not yet recruiting NCT03998748

Search NIH Clinical Center for Papillomatosis, Confluent and Reticulated

Genetic Tests for Papillomatosis, Confluent and Reticulated

Anatomical Context for Papillomatosis, Confluent and Reticulated

MalaCards organs/tissues related to Papillomatosis, Confluent and Reticulated:

Retina, Liver, Brain, Kidney, Pituitary, Skin, Heart

Publications for Papillomatosis, Confluent and Reticulated

Articles related to Papillomatosis, Confluent and Reticulated:

(show top 50) (show all 9792)
# Title Authors PMID Year
[Two brothers with brown, reticulate hyperpigmentations. Papillomatosis confluens et reticularis (Gougerot-Carteaud): familial occurrence and response to azithromycin]. 56
16827916 2006
Recurrent confluent and reticulate papillomatosis of Gougerot and Carteaud in siblings. 56
12780727 2003
Familial confluent and reticulated papillomatosis. 56
11843664 2002
Familial occurrence of confluent and reticulated papillomatosis. 56
7316560 1981
Familial cutaneous papillomatosis. 56
5835327 1965
Transcriptome analysis revealed changes of multiple genes involved in muscle hardness in grass carp (Ctenopharyngodon idellus) fed with faba bean meal. 61
31968291 2020
Could a freshwater fish be at the root of dystrophic crises in a coastal lagoon? 61
31822402 2020
The effects of Aeromonas hydrophila infection on oxidative stress, nonspecific immunity, autophagy, and apoptosis in the common carp. 61
31875516 2020
Effects of phytic acid and lysozyme on microbial composition and quality of grass carp (Ctenopharyngodon idellus) fillets stored at 4 °C. 61
31703873 2020
Diagnostic performance of 14-3-3η and anti-carbamylated protein antibodies in Rheumatoid Arthritis in Han population of Northern China. 61
31862264 2020
Occurrence of microplastics in the Han River and riverine fish in South Korea. 61
31806294 2020
Characterization and immune function of the interferon-β promoter stimulator-1 in the barbel chub, Squaliobarbus curriculus. 61
31837379 2020
Levels and human health risk assessments of heavy metals in fish tissue obtained from the agricultural heritage rice-fish-farming system in China. 61
31740309 2020
Effects of trichlorfon on oxidative stress, neurotoxicity, and cortisol levels in common carp, Cyprinus carpio L., at different temperatures. 61
31884009 2020
Food waste-based pellets for feeding grass carp (Ctenopharyngodon idellus): Adding baker's yeast and enzymes to enhance growth and immunity. 61
31869610 2020
Diphenyl diselenide dietary supplementation alleviates behavior impairment and brain damage in grass carp (Ctenopharyngodon idella) exposed to methylmercury chloride. 61
31760078 2020
Glycogen synthase kinase-3β (GSK-3β) of grass carp (Ctenopharyngodon idella): Synteny, structure, tissue distribution and expression in oleic acid (OA)-induced adipocytes and hepatocytes. 61
31846691 2020
Protein degradation of black carp (Mylopharyngodon piceus) muscle during cold storage. 61
31648092 2020
Characterization and expression of galectin-3 in grass carp (Ctenopharyngodon idella). 61
31830501 2020
Interactive effects of diclofenac and copper on bioconcentration and multiple biomarkers in crucian carp (Carassius auratus). 61
31677505 2020
Toxicokinetics and bioaccumulation characteristics of bisphenol analogues in common carp (Cyprinus carpio). 61
31954220 2020
Comparative toxicity of nanoparticulate and ionic copper following dietary exposure to common carp (Cyprinus carpio). 61
31794874 2020
Establishment of a brain cell line (FuB-1) from mummichog (Fundulus heteroclitus) and its application to fish virology, immunity and nanoplastics toxicology. 61
31791770 2020
Effects of dietary α-linolenic acid/linoleic acid ratio on growth performance, tissue fatty acid profile, serum metabolites and Δ6 fad and elovl5 gene expression in silver barb (Puntius gonionotus). 61
31802501 2020
Identification, expression profiling and localization of thoc in common carp ovary: Influence of thoc3-siRNA transient silencing. 61
31935505 2020
p38 mitogen-activated protein kinases (MAPKs) are involved in intestinal immune response to bacterial muramyl dipeptide challenge in Ctenopharyngodon idella. 61
31855810 2020
Optimal dietary curcumin improved growth performance, and modulated innate immunity, antioxidant capacity and related genes expression of NF-κB and Nrf2 signaling pathways in grass carp (Ctenopharyngodon idella) after infection with Aeromonas hydrophila. 61
31881329 2020
Anti-foodborne enteritis effect of galantamine potentially via acetylcholine anti-inflammatory pathway in fish. 61
31843701 2020
Embryotoxic and teratogenic profile of tretracycline at environmentally relevant concentrations on Cyprinus carpio. 61
31726589 2020
Occurrence, virulence gene and antimicrobial susceptibility profiles of Arcobacter spp. isolated from catla (Catla catla) in India. 61
32012305 2020
Nutrients Essential for Cognitive Function Are Typical Problem Nutrients in the Diets of Myanmar Primary School Children: Findings of a Linear Programming Analysis. 61
32013580 2020
Diversity of extracellular matrix morphology in vertebrate skeletal muscle. 61
31840868 2020
Binding of aldehydes to myofibrillar proteins as affected by two-step heat treatments. 61
31721226 2020
Magnetite nanoparticles effects on adverse responses of aquatic and terrestrial animal models. 61
31541956 2020
Poly-β-hydroxybutyrate (PHB) in bioflocs alters intestinal microbial community structure, immune-related gene expression and early Cyprinid herpesvirus 2 replication in gibel carp (Carassius auratus gibelio). 61
31846772 2020
Dietary biotin deficiency decreased growth performance and impaired the immune function of the head kidney, spleen and skin in on-growing grass carp (Ctenopharyngodon idella). 61
31857225 2020
The immunoprotective effect of whole-cell lysed inactivated vaccine with SWCNT as a carrier against Aeromonas hydrophila infection in grass carp. 61
31874296 2020
Antagonizing binding of cell cycle and apoptosis regulatory protein 1 (CARP-1) to the NEMO/IKKγ protein enhances the anticancer effect of chemotherapy. 61
32024692 2020
Reply to Comment on "Bioaccumulation of Methyl Siloxanes in Common Carp (Cyprinus carpio) and in an Estuarine Food Web in Northeastern China". 61
31927657 2020
Enzymatic, Non-enzymatatic Antioxidant Levels and Heat Shock Protein Expression as Indicators of Metal Induced Toxicity and Reproductive Modulation in Female Indian Major Carp Cirrhinus cirrhosus. 61
31834424 2020
Dietary supplementation of Geotrichum candidum improves growth, gut microbiota, immune-related gene expression and disease resistance in gibel carp CAS Ⅲ (Carassius auratus gibelio). 61
32035911 2020
Effect of β-1/3,1/6-glucan upon immune responses and bacteria in the gut of healthy common carp (Cyprinus carpio). 61
31782796 2020
Oral delivery of Bacillus subtilis spores expressing Clonorchis sinensis paramyosin protects grass carp from cercaria infection. 61
31912200 2020
Stable Genome Incorporation of Sperm-derived DNA Fragments in Gynogenetic Clone of Gibel Carp. 61
31902020 2020
Effects of microRNA-731 on inflammation and apoptosis by targeting CiGadd45aa in grass carp. 61
31838144 2020
Functional characterization of grass carp (Ctenopharyngodon idella) interleukin-2 in head kidney leukocytes. 61
31883471 2020
Copper Nanoparticles Mitigate the Growth, Immunity, and Oxidation Resistance in Common Carp (Cyprinus carpio). 61
32026341 2020
Grass carp reovirus VP56 represses interferon production by degrading phosphorylated IRF7. 61
32032764 2020
Virus susceptibility of a new cell line derived from the fin of black carp Mylopharyngodon piceus. 61
31755106 2020
Tissue distribution and bioaccumulation of a novel polyfluoroalkyl benzenesulfonate in crucian carp. 61
31881427 2020

Variations for Papillomatosis, Confluent and Reticulated

Expression for Papillomatosis, Confluent and Reticulated

Search GEO for disease gene expression data for Papillomatosis, Confluent and Reticulated.

Pathways for Papillomatosis, Confluent and Reticulated

GO Terms for Papillomatosis, Confluent and Reticulated

Sources for Papillomatosis, Confluent and Reticulated

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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