Papillomatosis, Confluent and Reticulated (CARP)

Categories: Genetic diseases, Skin diseases

Aliases & Classifications for Papillomatosis, Confluent and Reticulated

MalaCards integrated aliases for Papillomatosis, Confluent and Reticulated:

Name: Papillomatosis, Confluent and Reticulated 57
Papillomatosis, Reticulated and Confluent, of Gougerot and Carteaud 57
Papillomatosis, Familial Cutaneous 57
Carp 57



autosomal dominant

onset in teenage or young adult years
mode of inheritance is unclear
favorable response to treatment with minocycline or azithromycin


papillomatosis, confluent and reticulated:
Inheritance autosomal dominant inheritance


External Ids:

OMIM 57 167900
MedGen 42 C0263385

Summaries for Papillomatosis, Confluent and Reticulated

OMIM : 57 Confluent and reticulated papillomatosis is a dermatologic disorder characterized by onset in the teenage or young adult years of hyperkeratotic 1- to 2-mm papules that increase in size to 4 to 5 mm and coalesce to form a reticular pattern peripherally and a confluent pattern centrally. Early papules can be erythematous and later turn brown. Affected individuals are usually otherwise asymptomatic. The condition is distinct from acanthosis nigricans and tinea versicolor (infection with the yeast Pityrosporum), but can appear similar. Microscopic examination of skin biopsy shows epidermal undulation with hyperkeratosis, squat papillomatosis, and occasional acanthotic downward projections from the bases of the dells between papillomatous areas. Antibacterial agents such as minocycline and azithromycin are effective, perhaps due to their antiinflammatory and immunomodulatory properties (summary by Scheinfeld, 2006). (167900)

MalaCards based summary : Papillomatosis, Confluent and Reticulated, also known as papillomatosis, reticulated and confluent, of gougerot and carteaud, is related to carp allergy and cornelia de lange syndrome 1. The drugs Immunologic Factors and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include retina, liver and brain, and related phenotype is hyperkeratosis.

Wikipedia : 75 Confluent and reticulated papillomatosis of Gougerot and Carteaud is an uncommon but distinctive... more...

Related Diseases for Papillomatosis, Confluent and Reticulated

Diseases related to Papillomatosis, Confluent and Reticulated via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 255)
# Related Disease Score Top Affiliating Genes
1 carp allergy 12.3
2 cornelia de lange syndrome 1 11.2
3 acromelic frontonasal dysostosis 11.2
4 kleefstra syndrome 1 11.2
5 collins pope syndrome 11.2
6 papilloma 10.9
7 hemorrhagic disease 10.7
8 myxozoa 10.6
9 anoxia 10.6
10 hydrops, lactic acidosis, and sideroblastic anemia 10.4
11 hypoxia 10.4
12 polyploidy 10.4
13 b-cell lymphoma 10.4
14 bacterial infectious disease 10.3
15 insulin-like growth factor i 10.3
16 kidney disease 10.3
17 cytokine deficiency 10.3
18 rapidly involuting congenital hemangioma 10.3
19 acute kidney failure 10.3
20 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.3
21 47,xyy 10.3
22 ectodermal dysplasia-syndactyly syndrome 2 10.2
23 helix syndrome 10.2
24 stomatitis 10.2
25 48,xyyy 10.2
26 pseudoatrophoderma colli 10.2
27 paragangliomas 3 10.2
28 dermatitis 10.2
29 polykaryocytosis inducer 10.2
30 interstitial nephritis 10.2
31 peritonitis 10.2
32 triiodothyronine receptor auxiliary protein 10.1
33 posttransplant acute limbic encephalitis 10.1
34 metabolic acidosis 10.1
35 hyperglycemia 10.1
36 lymphopenia 10.1
37 hyperlipoproteinemia, type iii 10.1
38 erysipelas 10.1
39 coronary artery anomaly 10.1
40 coccidiosis 10.1
41 skin disease 10.1
42 tetraploidy 10.1
43 triploidy 10.1
44 arteries, anomalies of 10.0
45 atrial standstill 1 10.0
46 ataxia and polyneuropathy, adult-onset 10.0
47 riboflavin deficiency 10.0
48 angiosarcoma 10.0
49 rabies 10.0
50 chlamydia 10.0

Graphical network of the top 20 diseases related to Papillomatosis, Confluent and Reticulated:

Diseases related to Papillomatosis, Confluent and Reticulated

Symptoms & Phenotypes for Papillomatosis, Confluent and Reticulated

Human phenotypes related to Papillomatosis, Confluent and Reticulated:

# Description HPO Frequency HPO Source Accession
1 hyperkeratosis 32 HP:0000962

Symptoms via clinical synopsis from OMIM:

Skin Nails Hair Skin Histology:
epidermal undulation
squat papillomatosis
acanthotic downward projections from areas between the papillae

Skin Nails Hair Skin Electron Microscopy:
increased number of transitional cells between the stratum granulosum and stratum corneum

Skin Nails Hair Skin:
papillomatosis, reticular on the periphery, 1 to 2-mm growing to 4-5-mm and coalescing
papillomatosis, confluent centrally, erythematous turning brown later
scaly rash

Clinical features from OMIM:


Drugs & Therapeutics for Papillomatosis, Confluent and Reticulated

Drugs for Papillomatosis, Confluent and Reticulated (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 2
2 Pharmaceutical Solutions Phase 2
3 Cola Phase 1
4 Antibodies
5 Immunoglobulins
6 Anti-Infective Agents
7 Antibiotics, Antitubercular
8 Anti-Bacterial Agents

Interventional clinical trials:

# Name Status NCT ID Phase Drugs
1 A Multinational Phase IIb Study to Investigate the Efficacy and Safety of Subcutaneous Immunotherapy With a Modified Fish- Parvalbumin Given in Single Rising and Maintenance Doses to Subjects Allergic to Fish Completed NCT02382718 Phase 2
2 Safety Study of Compression Anastomotic Ring-locking Procedure (CARP) in Patients Undergoing Colonic Resection Completed NCT01451008 Phase 1
3 Clinical Follow-up of Anti-Carbamylated Antibody Status in Rheumatoid Arthritis Patients at 6, 12 and 18 Months Unknown status NCT02958319
4 CSP #411 - The Coronary Artery Revascularization Prophylaxis (CARP) Trial Completed NCT00032370
5 Allergy Against Different Species of Fish in Children and Adolescents Allergic to Fish Completed NCT02365168
6 Hyperbaric Oxygen Therapy for Antibiotic Refractory Pouchitis: a Phase 2A Clinical Trial Not yet recruiting NCT03526796
7 Electrophysiological Correlates of Cognition in Depression Not yet recruiting NCT03998748

Search NIH Clinical Center for Papillomatosis, Confluent and Reticulated

Genetic Tests for Papillomatosis, Confluent and Reticulated

Anatomical Context for Papillomatosis, Confluent and Reticulated

MalaCards organs/tissues related to Papillomatosis, Confluent and Reticulated:

Retina, Liver, Brain, Kidney, Pituitary, Skin, Heart

Publications for Papillomatosis, Confluent and Reticulated

Articles related to Papillomatosis, Confluent and Reticulated:

(show top 50) (show all 9462)
# Title Authors PMID Year
[Two brothers with brown, reticulate hyperpigmentations. Papillomatosis confluens et reticularis (Gougerot-Carteaud): familial occurrence and response to azithromycin]. 8
16827916 2006
Recurrent confluent and reticulate papillomatosis of Gougerot and Carteaud in siblings. 8
12780727 2003
Familial confluent and reticulated papillomatosis. 8
11843664 2002
Familial occurrence of confluent and reticulated papillomatosis. 8
7316560 1981
Familial cutaneous papillomatosis. 8
5835327 1965
Biochemical changes induced by dominant bacteria in chill-stored silver carp (Hypophthalmichthys molitrix) and GC-IMS identification of volatile organic compounds. 38
31421785 2019
Antioxidant and cryoprotective effects of hydrolysate from gill protein of bighead carp (Hypophthalmichthys nobilis) in preventing denaturation of frozen surimi. 38
31260976 2019
Black carp IRF5 interacts with TBK1 to trigger cell death following viral infection. 38
31260698 2019
Cloning, functional analysis, and microRNA-induced negative regulation of growth arrest and DNA damage-inducible 45 γ (Gadd45g) in grass carp (Ctenopharyngodon idella). 38
31129273 2019
The cardiotoxicity of the common carp (Cyprinus carpio) exposed to environmentally relevant concentrations of arsenic and subsequently relieved by zinc supplementation. 38
31344536 2019
Role of mannose-binding lectin in regulating monocytes/macrophages functions during Aeromonas hydrophila infection in grass carp, Ctenopharyngodon idella. 38
31173786 2019
Effects of l-arginine and l-histidine on heat-induced aggregation of fish myosin: Bighead carp (Aristichthys nobilis). 38
31174764 2019
Modification of gelatin hydrolysates from grass carp (Ctenopharyngodon idellus) scales by Maillard reaction: Antioxidant activity and volatile compounds. 38
31174797 2019
Stunning stress-induced textural softening in silver carp (Hypophthalmichthys molitrix) fillets and underlying mechanisms. 38
31174791 2019
Phylogeny and expression modulation of interleukin 1 receptors in grass carp (Ctenopharyngodon idella). 38
31145914 2019
Grass carp STK38 regulates IFN I expression by decreasing the phosphorylation level of GSK3β. 38
31175887 2019
Identification of signal pathways for immunotoxicity in the spleen of common carp exposed to chlorpyrifos. 38
31398777 2019
A novel pH-sensing indicator based on bacterial cellulose nanofibers and black carrot anthocyanins for monitoring fish freshness. 38
31320095 2019
Development and application of the analytical method for illicit drugs and metabolites in fish tissues. 38
31185337 2019
Growth performance and immune status in common carp Cyprinus carpio as affected by plant oil-based diets complemented with β-glucan. 38
31195114 2019
Functional characterization of three fish-specific interleukin-23 isoforms as regulators of Th17 signature cytokine expression in grass carp head kidney leukocytes. 38
31202965 2019
Effects of dietary supplementation of three strains of Lactococcus lactis on HIFs genes family expression of the common carp following Aeromonas hydrophila infection. 38
31252044 2019
Supplementation exogenous bile acid improved growth and intestinal immune function associated with NF-κB and TOR signalling pathways in on-growing grass carp (Ctenopharyngodon idella): Enhancement the effect of protein-sparing by dietary lipid. 38
31252043 2019
Effects of bioactive substance from turmeric on growth, skin mucosal immunity and antioxidant factors in common carp, Cyprinus carpio. 38
31265909 2019
Physico-chemical and functional properties of silver carp myosin glycated with konjac oligo-glucomannan: Effects of deacetylation. 38
31006463 2019
Effects of pomegranate peel extract on quality and microbiota composition of bighead carp (Aristichthys nobilis) fillets during chilled storage. 38
31027804 2019
Tissue residue depletion kinetics and withdrawal time estimation of doxycycline in grass carp, Ctenopharyngodon idella, following multiple oral administrations. 38
31220539 2019
Antibacterial activity of erythrocyte from grass carp (Ctenopharyngodon idella) is associated with phagocytosis and reactive oxygen species generation. 38
31176765 2019
Phytic acid disrupted intestinal immune status and suppressed growth performance in on-growing grass carp (Ctenopharyngodon idella). 38
31247320 2019
Grass carp ATG5 and ATG12 promote autophagy but down-regulate the transcriptional expression levels of IFN-I signaling pathway. 38
31252046 2019
Occurrence of Contracaecum bancrofti larvae in fish in the Murray-Darling Basin. 38
30017012 2019
Biochemical and molecular impacts of glyphosate-based herbicide on the gills of common carp. 38
31252126 2019
A role for CXC chemokines and their receptors in stress axis regulation of common carp. 38
31075272 2019
Identification and molecular characterization of peroxiredoxin 2 in grass carp (Ctenopharyngodon idella). 38
31202963 2019
Uptake and depuration of eight fluoroquinolones (FQs) in common carp (Cyprinus carpio). 38
31096125 2019
Functional characterisation of interleukin 34 in grass carp Ctenopharyngodon idella. 38
31146007 2019
Overexpression of CiIKKβ enhances CIK cell viability against ER stress. 38
31276789 2019
Identification of fish CMPK2 as an interferon stimulated gene against SVCV infection. 38
31125665 2019
Recombinant baculovirus BacCarassius-D4ORFs has potential as a live vector vaccine against CyHV-2. 38
31163296 2019
Zebrafish FGFR3 is a negative regulator of RLR pathway to decrease IFN expression. 38
31200068 2019
Isolation and characterization of a novel strain (YH01) of Micropterus salmoides rhabdovirus and expression of its glycoprotein by the baculovirus expression system. 38
31379143 2019
Dietary iron deficiency impaired intestinal immune function of on-growing grass carp under the infection of Aeromonas hydrophila: Regulation of NF-κB and TOR signaling. 38
31408728 2019
An evaluation of mixed plant protein in the diet of Yellow River carp (Cyprinus carpio): growth, body composition, biochemical parameters, and growth hormone/insulin-like growth factor 1. 38
31011873 2019
Effect of soluble soybean polysaccharides on freeze-denaturation and structure of myofibrillar protein of bighead carp surimi with liquid nitrogen freezing. 38
31145952 2019
Selenium deficiency inhibits micRNA-146a to promote ROS-induced inflammation via regulation of the MAPK pathway in the head kidney of carp. 38
31125664 2019
Molecular characterization and functional analysis of interferon regulatory factor 9 (irf9) in common carp Cyprinus carpio: a pivotal molecule in the Ifn response against pathogens. 38
31059592 2019
Effects of high-fat diet on growth performance, lipid accumulation and lipid metabolism-related MicroRNA/gene expression in the liver of grass carp (Ctenopharyngodon idella). 38
31071453 2019
Diphenyl diselenide dietary supplementation protects against methylmercury-chloride-induced immunotoxicity in the head kidney and spleen of grass carp (Ctenopharyngodon idella) via regulation of purinergic signaling and the NLRP3 inflammasome. 38
31028929 2019
Dietary administration of ferula (Ferula asafoetida) powder as a feed additive in diet of koi carp, Cyprinus carpio koi: effects on hemato-immunological parameters, mucosal antibacterial activity, digestive enzymes, and growth performance. 38
31256305 2019
Grass carp (Ctenopharyngodon idella) RSK2 protects cells anti-apoptosis by up-regulating BCL-2. 38
30905684 2019

Variations for Papillomatosis, Confluent and Reticulated

Expression for Papillomatosis, Confluent and Reticulated

Search GEO for disease gene expression data for Papillomatosis, Confluent and Reticulated.

Pathways for Papillomatosis, Confluent and Reticulated

GO Terms for Papillomatosis, Confluent and Reticulated

Sources for Papillomatosis, Confluent and Reticulated

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
71 Tocris
73 UMLS via Orphanet
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