CARP
MCID: PPL052
MIFTS: 34

Papillomatosis, Confluent and Reticulated (CARP)

Categories: Genetic diseases, Skin diseases

Aliases & Classifications for Papillomatosis, Confluent and Reticulated

MalaCards integrated aliases for Papillomatosis, Confluent and Reticulated:

Name: Papillomatosis, Confluent and Reticulated 57
Papillomatosis, Reticulated and Confluent, of Gougerot and Carteaud 57
Papillomatosis, Familial Cutaneous 57
Carp 57

Characteristics:

OMIM®:

57 (Updated 05-Mar-2021)
Inheritance:
autosomal dominant

Miscellaneous:
onset in teenage or young adult years
mode of inheritance is unclear
favorable response to treatment with minocycline or azithromycin


HPO:

31
papillomatosis, confluent and reticulated:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM® 57 167900
MedGen 41 C0263385

Summaries for Papillomatosis, Confluent and Reticulated

OMIM® : 57 Confluent and reticulated papillomatosis is a dermatologic disorder characterized by onset in the teenage or young adult years of hyperkeratotic 1- to 2-mm papules that increase in size to 4 to 5 mm and coalesce to form a reticular pattern peripherally and a confluent pattern centrally. Early papules can be erythematous and later turn brown. Affected individuals are usually otherwise asymptomatic. The condition is distinct from acanthosis nigricans and tinea versicolor (infection with the yeast Pityrosporum), but can appear similar. Microscopic examination of skin biopsy shows epidermal undulation with hyperkeratosis, squat papillomatosis, and occasional acanthotic downward projections from the bases of the dells between papillomatous areas. Antibacterial agents such as minocycline and azithromycin are effective, perhaps due to their antiinflammatory and immunomodulatory properties (summary by Scheinfeld, 2006). (167900) (Updated 05-Mar-2021)

MalaCards based summary : Papillomatosis, Confluent and Reticulated, also known as papillomatosis, reticulated and confluent, of gougerot and carteaud, is related to kleefstra syndrome 1 and carp allergy. The drugs Cola and Benzoyl peroxide have been mentioned in the context of this disorder. Affiliated tissues include retina, liver and kidney, and related phenotype is hyperkeratosis.

Wikipedia : 74 Confluent and reticulated papillomatosis of Gougerot and Carteaud is an uncommon but distinctive... more...

Related Diseases for Papillomatosis, Confluent and Reticulated

Diseases related to Papillomatosis, Confluent and Reticulated via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 241)
# Related Disease Score Top Affiliating Genes
1 kleefstra syndrome 1 11.1
2 carp allergy 11.0
3 cornelia de lange syndrome 1 10.9
4 jacobsen syndrome 10.9
5 acromelic frontonasal dysostosis 10.9
6 collins pope syndrome 10.9
7 hemorrhagic disease 10.6
8 myxozoa 10.6
9 anoxia 10.6
10 hypoxia 10.5
11 b-cell lymphoma 10.3
12 disease by infectious agent 10.3
13 cytokine deficiency 10.3
14 polyploidy 10.3
15 bacterial infectious disease 10.3
16 insulin-like growth factor i 10.3
17 helix syndrome 10.3
18 acute kidney failure 10.2
19 kidney disease 10.2
20 48,xyyy 10.2
21 rheumatoid arthritis 10.2
22 papilloma 10.2
23 ectodermal dysplasia-syndactyly syndrome 2 10.2
24 arthritis 10.2
25 stomatitis 10.2
26 paragangliomas 3 10.2
27 47,xyy 10.1
28 rapidly involuting congenital hemangioma 10.1
29 polykaryocytosis inducer 10.1
30 interstitial nephritis 10.1
31 peritonitis 10.1
32 triiodothyronine receptor auxiliary protein 10.1
33 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
34 telangiectasis 10.1
35 hyperglycemia 10.1
36 dentinogenesis imperfecta type 2 10.1
37 posttransplant acute limbic encephalitis 10.1
38 metabolic acidosis 10.0
39 lymphopenia 10.0
40 lipoprotein quantitative trait locus 10.0
41 erysipelas 10.0
42 hypoglycemia 10.0
43 tetraploidy 10.0
44 arteries, anomalies of 9.9
45 atrial standstill 1 9.9
46 lung cancer 9.9
47 ataxia and polyneuropathy, adult-onset 9.9
48 riboflavin deficiency 9.9
49 angiosarcoma 9.9
50 rabies 9.9

Graphical network of the top 20 diseases related to Papillomatosis, Confluent and Reticulated:



Diseases related to Papillomatosis, Confluent and Reticulated

Symptoms & Phenotypes for Papillomatosis, Confluent and Reticulated

Human phenotypes related to Papillomatosis, Confluent and Reticulated:

31
# Description HPO Frequency HPO Source Accession
1 hyperkeratosis 31 HP:0000962

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Mar-2021)
Skin Nails Hair Skin Histology:
hyperkeratosis
epidermal undulation
squat papillomatosis
acanthotic downward projections from areas between the papillae

Skin Nails Hair Skin Electron Microscopy:
increased number of transitional cells between the stratum granulosum and stratum corneum

Skin Nails Hair Skin:
papillomatosis, reticular on the periphery, 1 to 2-mm growing to 4-5-mm and coalescing
papillomatosis, confluent centrally, erythematous turning brown later
scaly rash

Clinical features from OMIM®:

167900 (Updated 05-Mar-2021)

Drugs & Therapeutics for Papillomatosis, Confluent and Reticulated

Drugs for Papillomatosis, Confluent and Reticulated (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cola Phase 1
2
Benzoyl peroxide Approved 94-36-0 7187
3
Miconazole Approved, Investigational, Vet_approved Early Phase 1 22916-47-8 4189
4
Sirolimus Approved, Investigational Early Phase 1 53123-88-9 5284616 6436030
5
Clotrimazole Approved, Vet_approved Early Phase 1 23593-75-1 2812
6 Immunoglobulins
7 Antibodies
8 Immunologic Factors Early Phase 1
9 Antifungal Agents Early Phase 1
10 Immunosuppressive Agents Early Phase 1
11 Antibiotics, Antitubercular Early Phase 1
12 Anti-Infective Agents Early Phase 1
13 Anti-Bacterial Agents Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety Study of Compression Anastomotic Ring-locking Procedure (CARP) in Patients Undergoing Colonic Resection Completed NCT01451008 Phase 1
2 Diagnostic Value of Antibodies Against Carbamylated Proteins in Psoriatic Arthritis. Completed NCT04173039
3 CSP #411 - The Coronary Artery Revascularization Prophylaxis (CARP) Trial Completed NCT00032370
4 COVID-19 Advanced Respiratory Physiology (CARP) Study Recruiting NCT04668313
5 Cognition, Age, and RaPamycin Effectiveness - DownregulatIon of thE mTor Pathway (CARPE DIEM) Recruiting NCT04200911 Early Phase 1 Rapamune
6 Immersive Multimedia as an Adjunctive Measure for Pain Control in Cancer Patients Recruiting NCT02995434

Search NIH Clinical Center for Papillomatosis, Confluent and Reticulated

Genetic Tests for Papillomatosis, Confluent and Reticulated

Anatomical Context for Papillomatosis, Confluent and Reticulated

MalaCards organs/tissues related to Papillomatosis, Confluent and Reticulated:

40
Retina, Liver, Kidney, Brain, Pituitary, Skin, Heart

Publications for Papillomatosis, Confluent and Reticulated

Articles related to Papillomatosis, Confluent and Reticulated:

(show top 50) (show all 10415)
# Title Authors PMID Year
1
[Two brothers with brown, reticulate hyperpigmentations. Papillomatosis confluens et reticularis (Gougerot-Carteaud): familial occurrence and response to azithromycin]. 57
16827916 2006
2
Recurrent confluent and reticulate papillomatosis of Gougerot and Carteaud in siblings. 57
12780727 2003
3
Familial confluent and reticulated papillomatosis. 57
11843664 2002
4
Familial occurrence of confluent and reticulated papillomatosis. 57
7316560 1981
5
Familial cutaneous papillomatosis. 57
5835327 1965
6
Saltiness perception enhancement of fish meat treated by microwave: The significance of conformational characteristics, water and sodium mobility. 61
33486362 2021
7
Effects of radio frequency heating on water distribution and structural properties of grass carp myofibrillar protein gel. 61
33199125 2021
8
Grass carp (Ctenopharyngodon idellus) Cdc25a down-regulates IFN 1 expression by reducing TBK1 phosphorylation. 61
33460677 2021
9
A strategy of ultrasound-assisted processing to improve the performance of bio-based coating preservation for refrigerated carp fillets (Ctenopharyngodon idellus). 61
33338838 2021
10
IRF1 and IRF2 act as positive regulators in antiviral response of large yellow croaker (Larimichthys crocea) by induction of distinct subgroups of type I IFNs. 61
33444646 2021
11
A new method for determining the denaturation temperature of collagen. 61
33406568 2021
12
Dibutyl phthalate-induced oxidative stress, inflammation and apoptosis in grass carp hepatocytes and the therapeutic use of taxifolin. 61
33131843 2021
13
Purification and identification of novel antioxidant peptides from silver carp muscle hydrolysate after simulated gastrointestinal digestion and transepithelial transport. 61
33191015 2021
14
The structural and ultrastructural organization of the cellular constituents of the trunk kidney of grass carp (Ctenopharyngodon idella). 61
32986903 2021
15
Masculinization in common carp (Cyprinus carpio) by androgen immersion: The interaction effect of hormone concentration and immersion time. 61
32901653 2021
16
Grass carp (Ctenopharyngodon idella) TNK1 modulates JAK-STAT signaling through phosphorylating STAT1. 61
33253749 2021
17
Alteration of lipid metabolism, autophagy, apoptosis and immune response in the liver of common carp (Cyprinus carpio) after long-term exposure to bisphenol A. 61
33493725 2021
18
Grass carp Mre11A activates IFN 1 response by targeting STING to defend against GCRV infection. 61
33129882 2021
19
Environmentally relevant concentration of cypermethrin or/and sulfamethoxazole induce neurotoxicity of grass carp: Involvement of blood-brain barrier, oxidative stress and apoptosis. 61
33127128 2021
20
Histological and immunohistochemical characterization of 17 gonadal tumours in koi carp (Cyprinus carpio koi). 61
33098685 2021
21
CMPK2 of triploid crucian carp is involved in immune defense against bacterial infection. 61
33186560 2021
22
The repertoire of vertebrate STAT transcription factors: Origin and variations in fish. 61
33271121 2021
23
The evolutionary analysis of complement component C5 and the gene co-expression network and putative interaction between C5a and C5a anaphylatoxin receptor (C5AR/CD88) in human and two Cyprinid fish. 61
33290783 2021
24
Gut melatonin: A potent candidate in the diversified journey of melatonin research. 61
33309697 2021
25
Modelling the accumulation of microplastics through food webs with the example Baiyangdian Lake, China. 61
33360469 2021
26
BFRs (PBDEs and HBCDs) in freshwater species from Lake Trasimeno (Italy): The singular case of HBCDs in red swamp crayfish. 61
33213903 2021
27
Digenean trematodes in Hungarian freshwater aquacultures. 61
33364471 2021
28
Seasonal dynamics of the activities of dissolved 137Cs and the 137Cs of fish in a shallow, hypereutrophic lake: Links to bottom-water oxygen concentrations. 61
33246721 2021
29
One step extraction followed by HPLC-ESI-MS/MS for multi-residue analysis of diacylhydrazine insecticides in water, sediment, and aquatic products. 61
33422838 2021
30
Cas12aFDet: A CRISPR/Cas12a-based fluorescence platform for sensitive and specific detection of Listeria monocytogenes serotype 4c. 61
33608071 2021
31
The function of zebrafish gpbar1 in antiviral response and lipid metabolism. 61
33285186 2021
32
Carp edema virus-related mortality in wild adult common carp (cyprinus carpio) in Italy. 61
33591616 2021
33
Establishment of a cell line from swim bladder of the Grass carp (Ctenopharyngodon idellus) for propagation of Grass Carp Reovirus Genotype II. 61
33460745 2021
34
Resolution of confluent and reticulated papillomatosis after bariatric surgery. 61
33164331 2021
35
Immune, inflammatory, autophagic and DNA damage responses to long-term H2O2 exposure in different tissues of common carp (Cyprinus carpio). 61
33248772 2021
36
Protective effects of black seed (Nigella sativa) diet supplementation in common carp (Cyprinus carpio) against immune depression, oxidative stress and metabolism dysfunction induced by glyphosate. 61
33285165 2021
37
The dynamic changes of arsenic biotransformation and bioaccumulation in muscle of freshwater food fish crucian carp during chronic dietborne exposure. 61
33279055 2021
38
Grass carp cGASL negatively regulates interferon activation through autophagic degradation of MAVS. 61
32987012 2021
39
Ecological stoichiometric and stable isotopic responses to microplastics are modified by food conditions in koi carp. 61
33011633 2021
40
The blood and mRNA levels of antioxidant-related factors in common carp (Cyprinus carpio) fed p-Coumaric acid. 61
33128193 2021
41
Uniparental genome elimination in Australian carp gudgeons. 61
33591327 2021
42
Scanning electron microscopy and morphological analysis reveal size-dependent changes in the scale surface ornamentation of tooth-carp Aphaniops hormuzensis (Teleostei; Aphaniidae). 61
33586268 2021
43
Genome-wide identification and characterization of olfactory receptor genes in common carp (Cyprinus carpio). 61
33539942 2021
44
Toxic effect of some heavy metals on hematology and histopathology of major carp (Catla catla). 61
32997242 2021
45
Suppression effect of plant-derived berberine on cyprinid herpesvirus 2 proliferation and its pharmacokinetics in Crucian carp (Carassius auratus gibelio). 61
33359191 2021
46
Retraction notice to "Effluent containing Rubrivivax gelatinosus promoting the yield, digestion system, disease resistance, mTOR and NF-kB signaling pathway, intestinal microbiota and aquaculture water quality of crucian carp" [Fish & Shellfish Immunology 94 (2019) 166-174]. 61
33602575 2021
47
LncRNA-WAS and lncRNA-C8807 interact with miR-142a-3p to regulate the inflammatory response in grass carp. 61
33582280 2021
48
Differential regulation of endoplasmic reticulum stress-induced autophagy and apoptosis in two strains of gibel carp (Carassius gibelio) exposed to acute waterborne cadmium. 61
33373863 2021
49
Gut Escherichia coli expressing Pb2+-adsorption protein reduces lead accumulation in grass carp, Ctenopharyngodon idellus. 61
33592445 2021
50
Assessment of DNA damage induced by endosulfan in grass carp (Ctenopharyngodon idella Valenciennes, 1844). 61
33550553 2021

Variations for Papillomatosis, Confluent and Reticulated

Expression for Papillomatosis, Confluent and Reticulated

Search GEO for disease gene expression data for Papillomatosis, Confluent and Reticulated.

Pathways for Papillomatosis, Confluent and Reticulated

GO Terms for Papillomatosis, Confluent and Reticulated

Sources for Papillomatosis, Confluent and Reticulated

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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