Papillomatosis, Confluent and Reticulated (CARP)

Categories: Genetic diseases, Skin diseases

Aliases & Classifications for Papillomatosis, Confluent and Reticulated

MalaCards integrated aliases for Papillomatosis, Confluent and Reticulated:

Name: Papillomatosis, Confluent and Reticulated 56
Papillomatosis, Reticulated and Confluent, of Gougerot and Carteaud 56
Papillomatosis, Familial Cutaneous 56
Carp 56



autosomal dominant

onset in teenage or young adult years
mode of inheritance is unclear
favorable response to treatment with minocycline or azithromycin


papillomatosis, confluent and reticulated:
Inheritance autosomal dominant inheritance


External Ids:

OMIM 56 167900
MedGen 41 C0263385

Summaries for Papillomatosis, Confluent and Reticulated

OMIM : 56 Confluent and reticulated papillomatosis is a dermatologic disorder characterized by onset in the teenage or young adult years of hyperkeratotic 1- to 2-mm papules that increase in size to 4 to 5 mm and coalesce to form a reticular pattern peripherally and a confluent pattern centrally. Early papules can be erythematous and later turn brown. Affected individuals are usually otherwise asymptomatic. The condition is distinct from acanthosis nigricans and tinea versicolor (infection with the yeast Pityrosporum), but can appear similar. Microscopic examination of skin biopsy shows epidermal undulation with hyperkeratosis, squat papillomatosis, and occasional acanthotic downward projections from the bases of the dells between papillomatous areas. Antibacterial agents such as minocycline and azithromycin are effective, perhaps due to their antiinflammatory and immunomodulatory properties (summary by Scheinfeld, 2006). (167900)

MalaCards based summary : Papillomatosis, Confluent and Reticulated, also known as papillomatosis, reticulated and confluent, of gougerot and carteaud, is related to carp allergy and kleefstra syndrome 1. The drugs Pharmaceutical Solutions and Cola have been mentioned in the context of this disorder. Affiliated tissues include retina, liver and kidney, and related phenotype is hyperkeratosis.

Wikipedia : 74 Confluent and reticulated papillomatosis of Gougerot and Carteaud is an uncommon but distinctive... more...

Related Diseases for Papillomatosis, Confluent and Reticulated

Diseases related to Papillomatosis, Confluent and Reticulated via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 260)
# Related Disease Score Top Affiliating Genes
1 carp allergy 12.3
2 kleefstra syndrome 1 11.4
3 cornelia de lange syndrome 1 11.2
4 jacobsen syndrome 11.2
5 acromelic frontonasal dysostosis 11.2
6 collins pope syndrome 11.2
7 papilloma 10.9
8 hemorrhagic disease 10.7
9 myxozoa 10.6
10 anoxia 10.6
11 b-cell lymphoma 10.4
12 polyploidy 10.4
13 bacterial infectious disease 10.4
14 hypoxia 10.4
15 cytokine deficiency 10.4
16 insulin-like growth factor i 10.3
17 kidney disease 10.3
18 acute kidney failure 10.3
19 47,xyy 10.3
20 stomatitis 10.3
21 48,xyyy 10.3
22 rapidly involuting congenital hemangioma 10.3
23 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.2
24 paragangliomas 3 10.2
25 ectodermal dysplasia-syndactyly syndrome 2 10.2
26 pseudoatrophoderma colli 10.2
27 helix syndrome 10.2
28 dermatitis 10.2
29 polykaryocytosis inducer 10.2
30 interstitial nephritis 10.2
31 peritonitis 10.2
32 hyperglycemia 10.2
33 dentinogenesis imperfecta type 2 10.2
34 posttransplant acute limbic encephalitis 10.2
35 triiodothyronine receptor auxiliary protein 10.1
36 metabolic acidosis 10.1
37 lymphopenia 10.1
38 erysipelas 10.1
39 telangiectasis 10.1
40 coccidiosis 10.1
41 skin disease 10.1
42 tetraploidy 10.1
43 triploidy 10.1
44 arteries, anomalies of 10.0
45 atrial standstill 1 10.0
46 ataxia and polyneuropathy, adult-onset 10.0
47 riboflavin deficiency 10.0
48 hyperlipoproteinemia, type iii 10.0
49 lipoprotein quantitative trait locus 10.0
50 angiosarcoma 10.0

Graphical network of the top 20 diseases related to Papillomatosis, Confluent and Reticulated:

Diseases related to Papillomatosis, Confluent and Reticulated

Symptoms & Phenotypes for Papillomatosis, Confluent and Reticulated

Human phenotypes related to Papillomatosis, Confluent and Reticulated:

# Description HPO Frequency HPO Source Accession
1 hyperkeratosis 31 HP:0000962

Symptoms via clinical synopsis from OMIM:

Skin Nails Hair Skin Histology:
epidermal undulation
squat papillomatosis
acanthotic downward projections from areas between the papillae

Skin Nails Hair Skin Electron Microscopy:
increased number of transitional cells between the stratum granulosum and stratum corneum

Skin Nails Hair Skin:
papillomatosis, reticular on the periphery, 1 to 2-mm growing to 4-5-mm and coalescing
papillomatosis, confluent centrally, erythematous turning brown later
scaly rash

Clinical features from OMIM:


Drugs & Therapeutics for Papillomatosis, Confluent and Reticulated

Drugs for Papillomatosis, Confluent and Reticulated (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 2
2 Cola Phase 1
Benzoyl peroxide Approved 94-36-0 7187
4 Antibodies
5 Immunologic Factors
6 Immunoglobulins
7 Anti-Bacterial Agents
8 Antibiotics, Antitubercular

Interventional clinical trials:

# Name Status NCT ID Phase Drugs
1 A Multinational Phase IIb Study to Investigate the Efficacy and Safety of Subcutaneous Immunotherapy With a Modified Fish- Parvalbumin Given in Single Rising and Maintenance Doses to Subjects Allergic to Fish Completed NCT02382718 Phase 2
2 Safety Study of Compression Anastomotic Ring-locking Procedure (CARP) in Patients Undergoing Colonic Resection Completed NCT01451008 Phase 1
3 Clinical Follow-up of Anti-Carbamylated Antibody Status in Rheumatoid Arthritis Patients at 6, 12 and 18 Months Unknown status NCT02958319
4 Diagnostic Value of Antibodies Against Carbamylated Proteins in Psoriatic Arthritis. Completed NCT04173039
5 CSP #411 - The Coronary Artery Revascularization Prophylaxis (CARP) Trial Completed NCT00032370
6 Allergy Against Different Species of Fish in Children and Adolescents Allergic to Fish Completed NCT02365168
7 Electrophysiological Correlates of Cognition in Depression Recruiting NCT03998748
8 Hyperbaric Oxygen Therapy for Antibiotic Refractory Pouchitis: a Phase 2A Clinical Trial Not yet recruiting NCT03526796

Search NIH Clinical Center for Papillomatosis, Confluent and Reticulated

Genetic Tests for Papillomatosis, Confluent and Reticulated

Anatomical Context for Papillomatosis, Confluent and Reticulated

MalaCards organs/tissues related to Papillomatosis, Confluent and Reticulated:

Retina, Liver, Kidney, Brain, Pituitary, Skin, Heart

Publications for Papillomatosis, Confluent and Reticulated

Articles related to Papillomatosis, Confluent and Reticulated:

(show top 50) (show all 10017)
# Title Authors PMID Year
[Two brothers with brown, reticulate hyperpigmentations. Papillomatosis confluens et reticularis (Gougerot-Carteaud): familial occurrence and response to azithromycin]. 56
16827916 2006
Recurrent confluent and reticulate papillomatosis of Gougerot and Carteaud in siblings. 56
12780727 2003
Familial confluent and reticulated papillomatosis. 56
11843664 2002
Familial occurrence of confluent and reticulated papillomatosis. 56
7316560 1981
Familial cutaneous papillomatosis. 56
5835327 1965
Differentiating wild, lake-farmed and pond-farmed carp using stable isotope and multi-element analysis of fish scales with chemometrics. 61
32480259 2020
The mechanism for improving the flesh quality of grass carp (Ctenopharyngodon idella) following the micro-flowing water treatment using a UPLC-QTOF/MS based metabolomics method. 61
32446027 2020
Splicing variants of grass carp (Ctenopharyngodon idellus) IL-21: Functions in IgM+ B cell proliferation and IgM secretion. 61
32387557 2020
Pattern recognition receptors in grass carp Ctenopharyngodon idella: II. Organization and expression analysis of NOD-like receptors. 61
32418892 2020
A full evaluation of chiral phenylpyrazole pesticide flufiprole and the metabolites to non-target organism in paddy field. 61
32434115 2020
Correlations between microbiota succession and flavor formation during fermentation of Chinese low-salt fermented common carp (Cyprinus carpio L.) inoculated with mixed starter cultures. 61
32336353 2020
Evaluating the potential role of bioactive chemicals on the distribution of invasive Asian carp upstream and downstream from river mile 278 in the Illinois waterway. 61
32470670 2020
FTR67, a member of the fish-specific finTRIM family, triggers IFN pathway and against spring viremia of carp virus. 61
32334126 2020
Molecular characterization and biological function of a tandem-repeat galectin-9 in Qihe crucian carp Carassius auratus. 61
32442500 2020
Grass carp (Ctenopharyngodon idella) PACT induces cell apoptosis and activates NF-кB via PKR. 61
32454210 2020
Black carp TRAFD1 restrains MAVS-mediated antiviral signaling during the innate immune activation. 61
32334128 2020
Do bigheaded carp act as a phosphorus source for phytoplankton in (sub)tropical Chinese reservoirs? 61
32422412 2020
Molecular characterization of yellow catfish (Pelteobagrus fulvidraco) IRF7 suggests involvement in innate immune response. 61
32278862 2020
Mediation of oxidative stress toxicity induced by pyrethroid pesticides in fish. 61
32289527 2020
TAT-tagging of VIP exerts positive allosteric modulation of the PAC1 receptor and enhances VIP neuroprotective effect in the MPTP mouse model of Parkinson's disease. 61
32335135 2020
Reactivation of cyprinid herpesvirus 2 (CyHV-2) in asymptomatic surviving goldfish Carassius auratus (L.) under immunosuppression. 61
32439507 2020
IRF9 promotes apoptosis and innate immunity by inhibiting SIRT1-p53 axis in fish. 61
32439513 2020
The potential benefits of orange peels derived pectin on serum and skin mucus immune parameters, antioxidant defence and growth performance in common carp (Cyprinus carpio). 61
32325217 2020
Effect of Yucca schidigera extract on the growth performance, intestinal antioxidant status, immune response, and tight junctions of mirror carp (Cyprinus carpio). 61
32422190 2020
Dietary phytic acid weakened the antimicrobial activity and aggravated the inflammatory status of head kidney, spleen and skin in on-growing grass carp (Ctenopharyngodon idella). 61
32439508 2020
The comparison of ultrasound-assisted thawing, air thawing and water immersion thawing on the quality of slow/fast freezing bighead carp (Aristichthys nobilis) fillets. 61
32208187 2020
Developing a unidirectionally permeable edible film based on ĸ-carrageenan and gelatin for visually detecting the freshness of grass carp fillets. 61
32507192 2020
Comparison of intracellular trace element distributions in the liver and gills of the invasive freshwater fish species, Prussian carp (Carassius gibelio Bloch, 1782). 61
32388370 2020
Waterborne Cu exposure increased lipid deposition and lipogenesis by affecting Wnt/β-catenin pathway and the β-catenin acetylation levels of grass carp Ctenopharyngodon idella. 61
32244122 2020
Black carp RIPK1 negatively regulates MAVS-mediated antiviral signaling during the innate immune activation. 61
32376280 2020
A fish cytokine related to human IL-3, IL-5, and GM-CSF, induces development of eosinophil/basophil/mast-cell type (EBM) granulocytes. 61
32147469 2020
Combining bivalve (Corbicula fluminea) and filter-feeding fish (Aristichthys nobilis) enhances the bioremediation effect of algae: An outdoor mesocosm study. 61
32330725 2020
The many faces of transferrin: Does genotype modulate immune response? 61
32417431 2020
New invertebrate species as potential CyHV-3 reservoirs: A case study of common carp mortalities in hyperthermal conditions. 61
32449204 2020
Ca2+ plays an antiviral role by increasing p53 expression to achieve protection against spring viraemia of carp virus infection. 61
32408017 2020
Bisphenol A regulates cytochrome P450 1B1 through miR-27b-3p and induces carp lymphocyte oxidative stress leading to apoptosis. 61
32430284 2020
3nLcn2, a teleost lipocalin 2 that possesses antimicrobial activity and inhibits bacterial infection in triploid crucian carp. 61
32283247 2020
Proteomic profiling reveals the differential toxic responses of gills of common carp exposed to nanosilver and silver nitrate. 61
32213387 2020
Hydroxycoumarin efficiently inhibits spring viraemia of carp virus infection in vitro and in vivo. 61
32390373 2020
Studies on the clinical symptoms, virus distribution, and mRNA expression of several antiviral immunity-related genes in grass carp after infection with genotype II grass carp reovirus. 61
32399788 2020
DEHP induces neutrophil extracellular traps formation and apoptosis in carp isolated from carp blood via promotion of ROS burst and autophagy. 61
32179220 2020
Ginsenoside Rg3 inhibits grass carp reovirus replication in grass carp ovarian epithelial cells. 61
32224212 2020
Characterization of the monoclonal antibody specific to the ORF72 protein of koi herpesvirus and cellular distribution analysis of the viral protein. 61
32449196 2020
Diversity of antimicrobial-resistant pathogens from a freshwater ornamental fish farm. 61
31602688 2020
Neurobehavioral, apoptotic, and DNA damaging effects of sub-chronic profenofos exposure on the brain tissue of Cyprinus carpio L.: Antagonistic role of Geranium essential oil. 61
32408004 2020
Evaluation on the antiviral effect of a hydroxycoumarin against infectious hematopoietic necrosis virus infection in vitro and in vivo. 61
32380168 2020
Identification of type I IFNs and their receptors in a cyprinid fish, the topmouth culter Culter alburnus. 61
32387477 2020
Transcriptome analysis provides insights into the antiviral response in the spleen of gibel carp (Carassius auratus gibelio) after poly I: C treatment. 61
32247830 2020
Progesterone affects the transcription of genes in the circadian rhythm signaling and hypothalamic-pituitary-gonadal axes and changes the sex ratio in crucian carp (Carassius auratus). 61
32279014 2020
The dynamic effects of different inorganic arsenic species in crucian carp (Carassius auratus) liver during chronic dietborne exposure: Bioaccumulation, biotransformation and oxidative stress. 61
32335454 2020

Variations for Papillomatosis, Confluent and Reticulated

Expression for Papillomatosis, Confluent and Reticulated

Search GEO for disease gene expression data for Papillomatosis, Confluent and Reticulated.

Pathways for Papillomatosis, Confluent and Reticulated

GO Terms for Papillomatosis, Confluent and Reticulated

Sources for Papillomatosis, Confluent and Reticulated

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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