CARP
MCID: PPL052
MIFTS: 34

Papillomatosis, Confluent and Reticulated (CARP)

Categories: Genetic diseases, Skin diseases

Aliases & Classifications for Papillomatosis, Confluent and Reticulated

MalaCards integrated aliases for Papillomatosis, Confluent and Reticulated:

Name: Papillomatosis, Confluent and Reticulated 57
Papillomatosis, Reticulated and Confluent, of Gougerot and Carteaud 57
Papillomatosis, Familial Cutaneous 57
Carp 57

Characteristics:

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
autosomal dominant

Miscellaneous:
onset in teenage or young adult years
mode of inheritance is unclear
favorable response to treatment with minocycline or azithromycin


HPO:

31
papillomatosis, confluent and reticulated:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM® 57 167900
MedGen 41 C0263385

Summaries for Papillomatosis, Confluent and Reticulated

OMIM® : 57 Confluent and reticulated papillomatosis is a dermatologic disorder characterized by onset in the teenage or young adult years of hyperkeratotic 1- to 2-mm papules that increase in size to 4 to 5 mm and coalesce to form a reticular pattern peripherally and a confluent pattern centrally. Early papules can be erythematous and later turn brown. Affected individuals are usually otherwise asymptomatic. The condition is distinct from acanthosis nigricans and tinea versicolor (infection with the yeast Pityrosporum), but can appear similar. Microscopic examination of skin biopsy shows epidermal undulation with hyperkeratosis, squat papillomatosis, and occasional acanthotic downward projections from the bases of the dells between papillomatous areas. Antibacterial agents such as minocycline and azithromycin are effective, perhaps due to their antiinflammatory and immunomodulatory properties (summary by Scheinfeld, 2006). (167900) (Updated 05-Apr-2021)

MalaCards based summary : Papillomatosis, Confluent and Reticulated, also known as papillomatosis, reticulated and confluent, of gougerot and carteaud, is related to kleefstra syndrome 1 and carp allergy. The drugs Cola and Benzoyl peroxide have been mentioned in the context of this disorder. Affiliated tissues include retina, liver and kidney, and related phenotype is hyperkeratosis.

Wikipedia : 73 Confluent and reticulated papillomatosis of Gougerot and Carteaud is an uncommon but distinctive... more...

Related Diseases for Papillomatosis, Confluent and Reticulated

Diseases related to Papillomatosis, Confluent and Reticulated via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 249)
# Related Disease Score Top Affiliating Genes
1 kleefstra syndrome 1 11.1
2 carp allergy 11.0
3 cornelia de lange syndrome 1 10.9
4 jacobsen syndrome 10.9
5 acromelic frontonasal dysostosis 10.9
6 collins pope syndrome 10.9
7 hemorrhagic disease 10.6
8 myxozoa 10.6
9 anoxia 10.6
10 hypoxia 10.5
11 b-cell lymphoma 10.3
12 disease by infectious agent 10.3
13 cytokine deficiency 10.3
14 polyploidy 10.3
15 bacterial infectious disease 10.3
16 insulin-like growth factor i 10.3
17 helix syndrome 10.3
18 rheumatoid arthritis 10.2
19 acute kidney failure 10.2
20 48,xyyy 10.2
21 kidney disease 10.2
22 papilloma 10.2
23 ectodermal dysplasia-syndactyly syndrome 2 10.2
24 stomatitis 10.2
25 paragangliomas 3 10.2
26 arthritis 10.2
27 47,xyy 10.1
28 polykaryocytosis inducer 10.1
29 rapidly involuting congenital hemangioma 10.1
30 interstitial nephritis 10.1
31 peritonitis 10.1
32 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
33 telangiectasis 10.1
34 hyperglycemia 10.1
35 dentinogenesis imperfecta type 2 10.1
36 posttransplant acute limbic encephalitis 10.1
37 triiodothyronine receptor auxiliary protein 10.0
38 metabolic acidosis 10.0
39 lymphopenia 10.0
40 erysipelas 10.0
41 coccidiosis 10.0
42 hypoglycemia 10.0
43 tetraploidy 10.0
44 arteries, anomalies of 9.9
45 atrial standstill 1 9.9
46 lung cancer 9.9
47 ataxia and polyneuropathy, adult-onset 9.9
48 riboflavin deficiency 9.9
49 lipoprotein quantitative trait locus 9.9
50 angiosarcoma 9.9

Graphical network of the top 20 diseases related to Papillomatosis, Confluent and Reticulated:



Diseases related to Papillomatosis, Confluent and Reticulated

Symptoms & Phenotypes for Papillomatosis, Confluent and Reticulated

Human phenotypes related to Papillomatosis, Confluent and Reticulated:

31
# Description HPO Frequency HPO Source Accession
1 hyperkeratosis 31 HP:0000962

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
Skin Nails Hair Skin Histology:
hyperkeratosis
epidermal undulation
squat papillomatosis
acanthotic downward projections from areas between the papillae

Skin Nails Hair Skin Electron Microscopy:
increased number of transitional cells between the stratum granulosum and stratum corneum

Skin Nails Hair Skin:
papillomatosis, reticular on the periphery, 1 to 2-mm growing to 4-5-mm and coalescing
papillomatosis, confluent centrally, erythematous turning brown later
scaly rash

Clinical features from OMIM®:

167900 (Updated 05-Apr-2021)

Drugs & Therapeutics for Papillomatosis, Confluent and Reticulated

Drugs for Papillomatosis, Confluent and Reticulated (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cola Phase 1
2
Benzoyl peroxide Approved 94-36-0 7187
3
Clotrimazole Approved, Vet_approved Early Phase 1 23593-75-1 2812
4
Miconazole Approved, Investigational, Vet_approved Early Phase 1 22916-47-8 4189
5
Sirolimus Approved, Investigational Early Phase 1 53123-88-9 6436030 5284616
6 Immunoglobulins
7 Antibodies
8 Immunologic Factors Early Phase 1
9 Antibiotics, Antitubercular Early Phase 1
10 Immunosuppressive Agents Early Phase 1
11 Anti-Bacterial Agents Early Phase 1
12 Anti-Infective Agents Early Phase 1
13 Antifungal Agents Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety Study of Compression Anastomotic Ring-locking Procedure (CARP) in Patients Undergoing Colonic Resection Completed NCT01451008 Phase 1
2 Diagnostic Value of Antibodies Against Carbamylated Proteins in Psoriatic Arthritis. Completed NCT04173039
3 CSP #411 - The Coronary Artery Revascularization Prophylaxis (CARP) Trial Completed NCT00032370
4 COVID-19 Advanced Respiratory Physiology (CARP) Study Recruiting NCT04668313
5 Cognition, Age, and RaPamycin Effectiveness - DownregulatIon of thE mTor Pathway (CARPE DIEM) Recruiting NCT04200911 Early Phase 1 Rapamune
6 Immersive Multimedia as an Adjunctive Measure for Pain Control in Cancer Patients Recruiting NCT02995434

Search NIH Clinical Center for Papillomatosis, Confluent and Reticulated

Genetic Tests for Papillomatosis, Confluent and Reticulated

Anatomical Context for Papillomatosis, Confluent and Reticulated

MalaCards organs/tissues related to Papillomatosis, Confluent and Reticulated:

40
Retina, Liver, Kidney, Brain, Pituitary, Skin, Heart

Publications for Papillomatosis, Confluent and Reticulated

Articles related to Papillomatosis, Confluent and Reticulated:

(show top 50) (show all 10517)
# Title Authors PMID Year
1
[Two brothers with brown, reticulate hyperpigmentations. Papillomatosis confluens et reticularis (Gougerot-Carteaud): familial occurrence and response to azithromycin]. 57
16827916 2006
2
Recurrent confluent and reticulate papillomatosis of Gougerot and Carteaud in siblings. 57
12780727 2003
3
Familial confluent and reticulated papillomatosis. 57
11843664 2002
4
Familial occurrence of confluent and reticulated papillomatosis. 57
7316560 1981
5
Familial cutaneous papillomatosis. 57
5835327 1965
6
Effect of MTGase on silver carp myofibrillar protein gelation behavior after peroxidation induced by peroxyl radicals. 61
33556728 2021
7
One- and double-layered furcellaran/carp skin gelatin hydrolysate film system with antioxidant peptide as an innovative packaging for perishable foods products. 61
33647702 2021
8
Modeling acetylcholine esterase inhibition resulting from exposure to a mixture of atrazine and chlorpyrifos using a physiologically-based kinetic model in fish. 61
33582354 2021
9
Saltiness perception enhancement of fish meat treated by microwave: The significance of conformational characteristics, water and sodium mobility. 61
33486362 2021
10
Lipopolysaccharide-induced TNFα factor (LITAF) promotes inflammatory responses and activates apoptosis in zebrafish Danio rerio. 61
33588039 2021
11
IRF1 and IRF2 act as positive regulators in antiviral response of large yellow croaker (Larimichthys crocea) by induction of distinct subgroups of type I IFNs. 61
33444646 2021
12
Gut Escherichia coli expressing Pb2+-adsorption protein reduces lead accumulation in grass carp, Ctenopharyngodon idellus. 61
33592445 2021
13
Grass carp (Ctenopharyngodon idellus) Cdc25a down-regulates IFN 1 expression by reducing TBK1 phosphorylation. 61
33460677 2021
14
A strategy of ultrasound-assisted processing to improve the performance of bio-based coating preservation for refrigerated carp fillets (Ctenopharyngodon idellus). 61
33338838 2021
15
A new method for determining the denaturation temperature of collagen. 61
33406568 2021
16
Survival and malformations rates, oxidative status in early life stages of Cyprinus carpio due to exposure to environmentally realistic concentrations of paracetamol. 61
33454465 2021
17
Effects of radio frequency heating on water distribution and structural properties of grass carp myofibrillar protein gel. 61
33199125 2021
18
Effect of feeding habits of fish on the characteristics of collagenolytic proteases isolated from the visceral waste. 61
33746285 2021
19
Stability of viral haemorrhagic septicaemia virus, infectious hematopoietic necrosis virus and cyprinid herpesvirus 3 in various water samples. 61
33319917 2021
20
Integrated analysis of viral miRNAs, mRNA and protein in the caudal fin cells of C. auratus gibelio with cyprinid herpesvirus 2 infection. 61
33577719 2021
21
Direct and pleiotropic effects of the Masou Salmon Delta-5 Desaturase transgene in F1 channel catfish (Ictalurus punctatus). 61
33792795 2021
22
Big Data acquired by Internet of Things-enabled industrial multichannel wireless sensors networks for active monitoring and control in the smart grid Industry 4.0. 61
33659599 2021
23
Genome-wide identification and characterization of olfactory receptor genes in common carp (Cyprinus carpio). 61
33539942 2021
24
Sediment resuspension drives protist metacommunity structure and assembly in grass carp (Ctenopharyngodonidella) aquaculture ponds. 61
33757250 2021
25
Comparison of metabolic scaling between triploid and diploid common carp. 61
33811547 2021
26
Physiological performance of common carp (Cyprinus carpio, L., 1758) exposed to a sublethal copper/zinc/cadmium mixture. 61
33333321 2021
27
Purification and identification of novel antioxidant peptides from silver carp muscle hydrolysate after simulated gastrointestinal digestion and transepithelial transport. 61
33191015 2021
28
Cardiac ankyrin repeat protein contributes to dilated cardiomyopathy and heart failure. 61
33734499 2021
29
Carp edema virus and immune response in carp (Cyprinus carpio): Current knowledge. 61
33460151 2021
30
Whole genome sequencing of silver carp (Hypophthalmichthys molitrix) and bighead carp (Hypophthalmichthys nobilis) provide novel insights into their evolution and speciation. 61
33191666 2021
31
Cadmium-induced Oxidative Stress and Immunosuppression Mediated Mitochondrial Apoptosis via JNK-FoxO3a-PUMA pathway in Common Carp (Cyprinus carpio L.) Gills. 61
33631492 2021
32
Assessment bioaccumulation factor (BAF) of methyl siloxanes in crucian carp (Carassius auratus) around a siloxane production factory. 61
33582413 2021
33
The effects of cryopreservation and cold storage on sperm subpopulation structure of common carp (Cyprinus carpio L.). 61
33450240 2021
34
Environmentally relevant concentration of sulfamethoxazole-induced oxidative stress-cascaded damages in the intestine of grass carp and the therapeutic application of exogenous lycopene. 61
33540255 2021
35
Retraction notice to "Effluent containing Rubrivivax gelatinosus promoting the yield, digestion system, disease resistance, mTOR and NF-kB signaling pathway, intestinal microbiota and aquaculture water quality of crucian carp" [Fish & Shellfish Immunology 94 (2019) 166-174]. 61
33602575 2021
36
Black carp TRADD suppresses MAVS/IFN signaling during the innate immune activation. 61
33513437 2021
37
In vitro metabolic kinetics of cresyl diphenyl phosphate (CDP) in liver microsomes of crucian carp (Carassius carassius). 61
33529897 2021
38
Quality characteristics of fortified silver carp surimi with soluble dietary fiber: Effect of apple pectin and konjac glucomannan. 61
33548317 2021
39
Identification, expression and pro-inflammatory effect of interleukin-17 N in common carp (Cyprinus carpio L.). 61
33387658 2021
40
Saikosaponin a attenuates lead-induced kidney injury through activating Nrf2 signaling pathway. 61
33278595 2021
41
Dibutyl phthalate-induced oxidative stress, inflammation and apoptosis in grass carp hepatocytes and the therapeutic use of taxifolin. 61
33131843 2021
42
LncRNA-WAS and lncRNA-C8807 interact with miR-142a-3p to regulate the inflammatory response in grass carp. 61
33582280 2021
43
Broad-Spectrum Robust Direct Bactericidal Activity of Fish IFNφ1 Reveals an Antimicrobial Peptide-like Function for Type I IFNs in Vertebrates. 61
33568398 2021
44
Cas12aFDet: A CRISPR/Cas12a-based fluorescence platform for sensitive and specific detection of Listeria monocytogenes serotype 4c. 61
33608071 2021
45
Replication of heterologous glycoprotein-expressing chimeric recombinant snakehead rhabdoviruses (rSHRVs) and viral hemorrhagic septicemia viruses (rVHSVs) at different temperatures. 61
33727091 2021
46
Spatial and temporal variations in stable isotope values (δ13C and δ15N) of the primary and secondary consumers along the southern coastline of the Caspian Sea. 61
33485017 2021
47
The Infuence of Salicin on Rheological and Film-Forming Properties of Collagen. 61
33809811 2021
48
14-Membered resorcylic acid lactone derivatives with their anti-inflammatory from the fungus Aspergillus sp. ZJ-65. 61
33766742 2021
49
Development of an android app for estimating the water quality parameters in fish pond. 61
33651289 2021
50
The repertoire of vertebrate STAT transcription factors: Origin and variations in fish. 61
33271121 2021

Variations for Papillomatosis, Confluent and Reticulated

Expression for Papillomatosis, Confluent and Reticulated

Search GEO for disease gene expression data for Papillomatosis, Confluent and Reticulated.

Pathways for Papillomatosis, Confluent and Reticulated

GO Terms for Papillomatosis, Confluent and Reticulated

Sources for Papillomatosis, Confluent and Reticulated

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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