MCID: PPL026
MIFTS: 24

Papular Mucinosis

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Papular Mucinosis

MalaCards integrated aliases for Papular Mucinosis:

Name: Papular Mucinosis 20 58
Localized Lichen Myxedematosus 20 58
Lichen Myxedematosus 20 58
Lichen Myxoedematosus 20
Scleromyxedema 70

Characteristics:

Orphanet epidemiological data:

58
lichen myxedematosus
Age of onset: Adult,Infancy;

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

ICD10 via Orphanet 33 L98.5
UMLS via Orphanet 71 C0263390
UMLS 70 C0263390

Summaries for Papular Mucinosis

GARD : 20 Papular mucinosis is a rare skin disorder characterized by deposits of mucin in the skin. The terms "papular mucinosis" and "lichen myxoedematosus" are generally used interchangeably to describe the occurrence of this condition as a localized and less severe form, while the term scleromyxoedema refers to a generalized, more severe form. Signs and symptoms of the condition include the presence of small, firm, waxy papules on the skin that are confined to a few sites on the body. Affected individuals are typically otherwise healthy. The cause of the condition is unknown, but it is commonly associated with monoclonal gammopathy. It has also been reported in association with bone marrow cancers as well HIV infection, hepatitis C, exposure to toxic oil and contaminated L-tryptophan. Localized papular mucinosis typically does not require therapy, but topical corticosteroids and oral isotretinoin may help to reduce hardening of the skin.

MalaCards based summary : Papular Mucinosis, also known as localized lichen myxedematosus, is related to acral persistent papular mucinosis and scleromyxedema. An important gene associated with Papular Mucinosis is F13A1 (Coagulation Factor XIII A Chain). Affiliated tissues include skin and bone marrow.

Wikipedia : 73 Papular mucinosis (also known as Scleromyxedema, "Generalized lichen myxedematosus," and "Sclerodermoid... more...

Related Diseases for Papular Mucinosis

Diseases in the Papular Mucinosis family:

Papular Mucinosis of Infancy

Diseases related to Papular Mucinosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 acral persistent papular mucinosis 11.6
2 scleromyxedema 11.5
3 self-healing papular mucinosis 11.5
4 papular mucinosis of infancy 11.5
5 nodular lichen myxedematosus 11.5
6 localized lichen myxedematosus with mixed features of different subtypes 11.2
7 localized lichen myxedematosus with monoclonal gammopathy or systemic symptoms 11.2
8 systemic scleroderma 10.4
9 scleroderma, familial progressive 10.3
10 myopathy 10.3
11 myxedema 10.2
12 mucinoses 10.2
13 raynaud phenomenon 10.2
14 carpal tunnel syndrome 10.1
15 systemic lupus erythematosus 10.1
16 hypothyroidism 10.1
17 molluscum contagiosum 10.1
18 hypereosinophilic syndrome 10.1
19 scleromyxedema without monoclonal gammopathy 10.1
20 polyneuropathy 10.1
21 toxoplasmosis 10.1
22 hashimoto thyroiditis 10.0
23 myositis 10.0
24 hepatitis c virus 10.0
25 metabolic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 10.0
26 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.0
27 panniculitis 10.0
28 urticaria 10.0
29 angioedema 10.0
30 hepatitis c 10.0
31 viral hepatitis 10.0
32 plasmacytoma 10.0
33 thyroiditis 10.0
34 monoclonal gammopathy of uncertain significance 10.0
35 acroosteolysis 10.0
36 macroglossia 10.0
37 immune deficiency disease 10.0
38 mycosis fungoides 10.0
39 myeloma, multiple 10.0
40 ocular motor apraxia 10.0
41 leptin deficiency or dysfunction 10.0
42 myopathy, scapulohumeroperoneal 10.0
43 exanthem 10.0
44 bone resorption disease 10.0
45 chronic myelomonocytic leukemia 10.0
46 myxofibrosarcoma 10.0
47 polymyositis 10.0
48 dermatomyositis 10.0
49 multicentric reticulohistiocytosis 10.0
50 plica syndrome 10.0

Graphical network of the top 20 diseases related to Papular Mucinosis:



Diseases related to Papular Mucinosis

Symptoms & Phenotypes for Papular Mucinosis

Drugs & Therapeutics for Papular Mucinosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Investigating Hyaluronidase in Treating Oral Microstomia in Patients With Sclerosing Skin Disease Withdrawn NCT04656704 Early Phase 1 hyaluronidase injected intradermally

Search NIH Clinical Center for Papular Mucinosis

Genetic Tests for Papular Mucinosis

Anatomical Context for Papular Mucinosis

MalaCards organs/tissues related to Papular Mucinosis:

40
Skin, Bone Marrow

Publications for Papular Mucinosis

Articles related to Papular Mucinosis:

(show top 50) (show all 172)
# Title Authors PMID Year
1
An atypical presentation of discrete papular mucinosis in the genitalia mimicking a molluscum contagiosum infection. 61
33054946 2020
2
A case report and differential diagnosis of pruritic pretibial skin lesions. 61
32975304 2020
3
Lichen Myxedematosus: Case Report and Review of Literature. 61
32550685 2020
4
A rare case of acral persistent papular mucinosis. 61
32128185 2020
5
Scleroderma with Acro-Osteolysis and Papular Mucinosis Resembling Multicentric Reticulohistiocytosis. 61
32789122 2020
6
Scleromyxedema in a patient with thyroid disease: an atypical case or a case for revised criteria? 61
32074156 2020
7
Localized Lichen Myxedematosus With Plasma Cell Light Chain Restriction: Is It the Exception or the Rule? 61
30601206 2019
8
Acral persistent papular mucinosis with pruritic skin lesions. 61
30156641 2018
9
Acral persistent papular mucinosis with pruritic skin lesions. 61
33293141 2018
10
Papular mucinosis, or localized lichen myxedematosis (LM) (discrete papular type). 61
29447654 2017
11
Scleromyxoedema in a dog. 61
28439995 2017
12
Cutaneous mucinosis in a patient taking ustekinumab for palmoplantar psoriasis. 61
28329515 2017
13
Localized lichen myxedematosus in childhood: what is the accurate diagnosis? 61
27667483 2017
14
Papular mucinosis with monotypic plasma cells in a child. 61
27358105 2017
15
Acral persistent papular mucinosis (APPM): Dermoscopy of an uncommon disease. 61
28087015 2017
16
Atypical discrete papular lichen myxedematosus associated with monoclonal gammopathy: report of four cases and review of the literature. 61
27422288 2016
17
Case for diagnosis. Lichen myxedematosus. 61
28099617 2016
18
Acral papular mucinosis: a new case of this rare entity. 61
28300913 2016
19
Acral Persistent Papular Mucinosis with Partial Response to Tacrolimus Ointment. 61
27489445 2016
20
[Atypical scleromyxedema with a granulomatous histological pattern and delayed sclerosis]. 61
26969478 2016
21
Treatment of acral persistent papular mucinosis using an Erbium-YAG laser. 61
25952726 2015
22
Scleromyxedema (papular mucinosis) with dermato-neuro syndrome: a rare, potentially fatal complication. 61
26051450 2015
23
Papular mucinosis associated with monoclonal gammopathy of unknown significance. 61
25751354 2015
24
Papular mucinosis of the breast after radiation therapy. 61
25370988 2014
25
A mimic of self-healing juvenile cutaneous mucinosis? 61
25233809 2014
26
Bilateral madarosis due to papular mucinosis. 61
25201851 2014
27
Localized cutaneous mucinosis associated with multiple myeloma: a rare presentation. 61
25071283 2014
28
Adult variant of self-healing papular mucinosis in a patient treated with interferon α2a. 61
24685873 2014
29
Acral persistent papular mucinosis: is it an under-diagnosed disease? 61
24656271 2014
30
A case of localized papular mucinosis showing excellent response to cyclophosphamide. 61
24700950 2014
31
Scleromyxedema: a case report and review of the literature. 61
23874293 2013
32
[Facial papules and pneumothoraces. Birt-Hogg-Dubé syndrome]. 61
23052100 2012
33
The combination of bortezomib and dexamethasone is an efficient therapy for relapsed/refractory scleromyxedema: a rare disease with new clinical insights. 61
22404151 2012
34
Atypical case of discrete papular mucinosis involving acral and nuchal regions in an adult. 61
22313743 2012
35
An interstitial granulomatous pattern in localized lichen myxedematosus with associated monoclonal gammopathy. 61
22235972 2012
36
[Atypical papular mucinosis with initial histological findings evocative of granuloma annulare]. 61
22225745 2012
37
Treatment of acral persistent papular mucinosis with electrocoagulation. 61
21781629 2011
38
Acral persistent papular mucinosis: a case report and literature review. 61
21122068 2011
39
Localized papular mucinosis with IgA nephropathy: a case report. 61
21576580 2011
40
Widespread papules in a patient with human immunodeficiency virus. Papular mucinosis (PM) in association with HIV infection. 61
20831608 2010
41
Quantification of mast cells and blood vessels in the skin of patients with cutaneous mucinosis. 61
20442641 2010
42
[Papular mucinosis associated with hypothyroidism]. 61
20464094 2010
43
Adult self-healing papular mucinosis on genital skin. 61
19817766 2009
44
Folliculitis, follicular mucinosis, and papular mucinosis as a presentation of chronic myelomonocytic leukemia. 61
19624994 2009
45
Papular Mucinosis Associated with Systemic Lupus Erythematosus. 61
27303200 2008
46
Spontaneous resolution of facial papular mucinosis in a transplant patient. 61
18638226 2008
47
Papular mucinosis (discrete papular lichen myxedematosus). 61
18627750 2008
48
Treatment of localized lichen myxedematosus of discrete type with tacrolimus ointment. 61
18280368 2008
49
Reactive pseudotumoural papular mucinosis: a new clinicopathological presentation? 61
18211426 2008
50
Resolution of papular mucinosis in a person with HIV infection. 61
17717886 2007

Variations for Papular Mucinosis

Expression for Papular Mucinosis

Search GEO for disease gene expression data for Papular Mucinosis.

Pathways for Papular Mucinosis

GO Terms for Papular Mucinosis

Sources for Papular Mucinosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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