MCID: PRC051
MIFTS: 29

Paracetamol Poisoning

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Paracetamol Poisoning

MalaCards integrated aliases for Paracetamol Poisoning:

Name: Paracetamol Poisoning 58
Acetaminophen Poisoning 58

Classifications:



External Ids:

Orphanet 58 ORPHA464458

Summaries for Paracetamol Poisoning

MalaCards based summary : Paracetamol Poisoning, also known as acetaminophen poisoning, is related to acute liver failure and hepatic encephalopathy. An important gene associated with Paracetamol Poisoning is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. The drugs Ondansetron and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include liver, monocytes and endothelial.

Wikipedia : 73 Paracetamol poisoning, also known as acetaminophen poisoning, is caused by excessive use of the... more...

Related Diseases for Paracetamol Poisoning

Diseases related to Paracetamol Poisoning via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 acute liver failure 30.7 GC F2
2 hepatic encephalopathy 30.5 GC F2
3 disseminated intravascular coagulation 29.5 F5 F2
4 hepatic coma 10.4
5 acute kidney failure 10.4
6 metabolic acidosis 10.3
7 liver disease 10.3
8 alcohol dependence 10.1
9 ocular motor apraxia 10.1
10 acute kidney tubular necrosis 10.1
11 alcohol use disorder 10.1
12 pancreatitis 10.1
13 kidney disease 10.1
14 myocarditis 10.1
15 toxic myocarditis 10.1
16 encephalopathy 10.1
17 pancytopenia 10.0
18 48,xyyy 10.0
19 analbuminemia 10.0 GC F2
20 neural tube defects 9.9
21 cystic fibrosis 9.9
22 factor vii deficiency 9.9
23 ventricular fibrillation, paroxysmal familial, 1 9.9
24 exanthem 9.9
25 spina bifida occulta 9.9
26 non-alcoholic fatty liver disease 9.9
27 methemoglobinemia 9.9
28 cholestasis 9.9
29 angioedema 9.9
30 acute pancreatitis 9.9
31 cleft lip 9.9
32 hypoglycemia 9.9
33 cleft lip/palate 9.9
34 arteries, anomalies of 9.9
35 cardiac conduction defect 9.9
36 cyanosis, transient neonatal 9.9
37 metabolic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 9.9
38 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 9.9
39 lipoprotein quantitative trait locus 9.9
40 periventricular leukomalacia 9.9
41 urticaria 9.9
42 thrombocytopenia 9.9
43 pericarditis 9.9
44 anuria 9.9
45 lactic acidosis 9.9
46 hyperglycemia 9.9
47 congestive heart failure 9.9
48 hyperthyroidism 9.9
49 fatty liver disease 9.9
50 47,xyy 9.9

Graphical network of the top 20 diseases related to Paracetamol Poisoning:



Diseases related to Paracetamol Poisoning

Symptoms & Phenotypes for Paracetamol Poisoning

Drugs & Therapeutics for Paracetamol Poisoning

Drugs for Paracetamol Poisoning (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ondansetron Approved Phase 4 99614-02-5 4595
2 Neurotransmitter Agents Phase 4
3 Gastrointestinal Agents Phase 4
4 Psychotropic Drugs Phase 4
5 Antiemetics Phase 4
6 Dermatologic Agents Phase 4
7 Antipsychotic Agents Phase 4
8 Anti-Anxiety Agents Phase 4
9 Emetics Phase 4
10
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
11
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
12
Acetaminophen Approved Phase 2 103-90-2 1983
13
Cysteine Approved, Nutraceutical Phase 2 52-90-4 5862
14 Respiratory System Agents Phase 2
15 Anti-Infective Agents Phase 2
16 Expectorants Phase 2
17 Protective Agents Phase 2
18 Antidotes Phase 2
19 Antiviral Agents Phase 2
20 Antioxidants Phase 2
21 N-monoacetylcystine Phase 2
22 Liver Extracts Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomised Trial to Assess the Effectiveness of Pre-treatment With Ondansetron at Reducing Nausea and Vomiting in Patients Treated With Either the Conventional Regimen or a Modified Regimen of Acetylcysteine for Paracetamol Poisoning Completed NCT01050270 Phase 4 Ondansetron;acetylcysteine;acetylcysteine
2 A Prospective Randomized Controlled Trial of Adjunctive N-acetylcysteine (NAC) in Adult Patients With Pulmonary Tuberculosis: a Sub-study of TB Sequel Recruiting NCT03702738 Phase 2 N-acetyl cysteine
3 The Markers and Paracetamol Poisoning Study 2 - Early Diagnosis of Drug-induced Liver Injury Using Point of Care Detection of microRNA Recruiting NCT03497104

Search NIH Clinical Center for Paracetamol Poisoning

Genetic Tests for Paracetamol Poisoning

Anatomical Context for Paracetamol Poisoning

MalaCards organs/tissues related to Paracetamol Poisoning:

40
Liver, Monocytes, Endothelial, Bone Marrow, Colon, Myeloid

Publications for Paracetamol Poisoning

Articles related to Paracetamol Poisoning:

(show top 50) (show all 698)
# Title Authors PMID Year
1
N-acetyl cysteine co-treatment abates perfluorooctanoic acid-induced reproductive toxicity in male rats. 61
33724529 2021
2
Acetaminophen poisoning: reclaiming the definition of recovery. 61
32400217 2021
3
An insight on safety, efficacy, and molecular docking study reports of N-acetylcysteine and its compound formulations. 61
33638319 2021
4
Predicting mortality from acetaminophen poisoning shortly after hospital presentation. 61
33507553 2021
5
Paracetamol overdose in the newborn and infant: a life-threatening event. 61
33388821 2021
6
Metabolic and mitochondrial treatments for severe paracetamol poisoning: a systematic review. 61
32762579 2020
7
The Multifaceted Therapeutic Role of N-Acetylcysteine (NAC) in Disorders Characterized by Oxidative Stress. 61
33380301 2020
8
Management of pharmaceutical and recreational drug poisoning. 61
33226502 2020
9
The Clinical Value of Routine Acetaminophen Level Screening in Pediatric Patients Presenting to the Emergency Department. 61
33236552 2020
10
The Clinical Value of Routine Acetaminophen Level Screening in Pediatric Patients Presenting to the Emergency Department. 61
32954693 2020
11
Late Diagnosis of Paracetamol Poisoning is Always Lethal in Young Adult. 61
32703356 2020
12
Fatal acetaminophen poisoning with hepatic microvesicular steatosis in a child after repeated administration of therapeutic doses. 61
32229318 2020
13
Systematic Review of Methemoglobinemia in Acetaminophen Poisoning. 61
32428237 2020
14
Electronic intravenous N-acetyl cysteine ordering tool: A retrospective review. 61
31668008 2020
15
Early acetaminophen-protein adducts predict hepatotoxicity following overdose (ATOM-5). 61
31760072 2020
16
Use of fomepizole, n-acetylcysteine, and hemodialysis for massive acetaminophen overdose. 61
31785980 2020
17
Myeloid cells in liver and bone marrow acquire a functionally distinct inflammatory phenotype during obesity-related steatohepatitis. 61
31076404 2020
18
Updated guidelines for the management of paracetamol poisoning in Australia and New Zealand. 61
31786822 2020
19
The MicroRNA-based Liquid Biopsy Improves Early Assessment of Lethal Acetaminophen Poisoning: A Case Report. 61
32086430 2020
20
A Novel MicroRNA Signature for Cholestatic Drugs in Human Hepatocytes and Its Translation into Novel Circulating Biomarkers for Drug-Induced Liver Injury Patients. 61
31198949 2020
21
Fomepizole as an Adjunctive Treatment in Severe Acetaminophen Toxicity. 61
31785979 2020
22
Acute paracetamol poisonings received at the Oran University Hospital. 61
32983905 2020
23
Acetaminophen Oxidation and Inflammatory Markers - A Review of Hepatic Molecular Mechanisms and Preclinical Studies. 61
32386489 2020
24
Acute Liver Failure of unclear cause? Acetaminophen-protein adducts make the diagnosis. 61
33778331 2020
25
Acetaminophen poisoning-induced heart injury: a case-based review. 61
31713183 2019
26
Cost Savings and Efficacy in Management of Paracetamol Poisoning in a 23-hours Emergency Department Observation Unit: A Comparison to Inpatient Care. 61
31819842 2019
27
[Diagnostics and treatment of selected clinically relevant, acute drug intoxications]. 61
31578621 2019
28
Paracetamol poisoning-related hospital admissions and deaths in Australia, 2004-2017. 61
31389025 2019
29
Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use. 61
31341611 2019
30
[Improved and harmonised laboratory analysis of paracetamol provides safer assessment of poisoning cases]. 61
31361324 2019
31
MicroRNA from a 12-h versus 20-h acetylcysteine infusion for paracetamol overdose. 61
30838890 2019
32
Safety and Efficacy of the SNAP 12-hour Acetylcysteine Regimen for the Treatment of Paracetamol Overdose. 61
31317129 2019
33
A Case Report of Massive Acetaminophen Poisoning Treated with a Novel "Triple Therapy": N-Acetylcysteine, 4-Methylpyrazole, and Hemodialysis. 61
30956824 2019
34
Presentations Related to Acute Paracetamol Intoxication in an Urban Emergency Department in Switzerland. 61
31885923 2019
35
An evaluation of the role of mixing techniques in the observed variation in acetylcysteine infusion concentrations. 61
30362143 2019
36
First aid interventions by laypeople for acute oral poisoning. 61
30565220 2018
37
Performance of an emergency department observation unit protocol in reducing length of stay for acetaminophen overdose: a retrospective study. 61
31179941 2018
38
Retrospective study of paracetamol poisoning in children aged zero to six years found no cases of liver injury. 61
29577416 2018
39
Pattern of Paracetamol Poisoning: Influence on Outcome and Complications. 61
30274302 2018
40
Acetaminophen Poisoning: A Case Based Approach. 61
32995209 2018
41
Acetaminophen Poisoning May Increase Coronary Artery Disease Risk: A Nationwide Cohort Study. 61
29302859 2018
42
TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence. 61
30111642 2018
43
Pediatric oral formulation of dendrimer-N-acetyl-l-cysteine conjugates for the treatment of neuroinflammation. 61
29680280 2018
44
Fewer adverse effects with a modified two-bag acetylcysteine protocol in paracetamol overdose. 61
29219630 2018
45
Anaphylactoid Reactions to Intravenous N-Acetylcysteine during Treatment for Acetaminophen Poisoning. 61
29423816 2018
46
Efficient diagnosis and treatment of acute paracetamol poisoning: cost-effectiveness analysis of approaches based on a hospital toxicovigilance program. 61
29687671 2018
47
Improving Interpretation of New and Old Serum Biomarkers of Drug-Induced Liver Injury Through Mechanistic Modeling. 61
29700994 2018
48
Correction to: Anaphylactoid Reactions to Intravenous N-Acetylcysteine during Treatment for Acetaminophen Poisoning. 61
29532341 2018
49
Acetaminophen Poisoning. 61
29858299 2018
50
Increased risk of congestive heart failure in patients with acetaminophen poisoning: A nationwide cohort study. 61
29327353 2018

Variations for Paracetamol Poisoning

Expression for Paracetamol Poisoning

Search GEO for disease gene expression data for Paracetamol Poisoning.

Pathways for Paracetamol Poisoning

Pathways related to Paracetamol Poisoning according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.16 F5 F2
2 10.78 F5 F2

GO Terms for Paracetamol Poisoning

Cellular components related to Paracetamol Poisoning according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.33 GC F5 F2
2 endoplasmic reticulum lumen GO:0005788 8.96 F5 F2
3 blood microparticle GO:0072562 8.62 GC F2

Biological processes related to Paracetamol Poisoning according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.26 F5 F2
2 blood coagulation GO:0007596 9.16 F5 F2
3 ER to Golgi vesicle-mediated transport GO:0006888 8.96 F5 F2
4 hemostasis GO:0007599 8.62 F5 F2

Sources for Paracetamol Poisoning

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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