MCID: PRC051
MIFTS: 30

Paracetamol Poisoning

Categories: Rare diseases

Aliases & Classifications for Paracetamol Poisoning

MalaCards integrated aliases for Paracetamol Poisoning:

Name: Paracetamol Poisoning 59
Acetaminophen Poisoning 59

Classifications:



External Ids:

Orphanet 59 ORPHA464458

Summaries for Paracetamol Poisoning

MalaCards based summary : Paracetamol Poisoning, also known as acetaminophen poisoning, is related to hepatitis and analbuminemia. An important gene associated with Paracetamol Poisoning is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. The drugs Acetaminophen and Ondansetron have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and heart.

Wikipedia : 76 Paracetamol poisoning, also known as acetaminophen poisoning, is caused by excessive use of the... more...

Related Diseases for Paracetamol Poisoning

Diseases related to Paracetamol Poisoning via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 hepatitis 10.1
2 analbuminemia 10.1 F2 GC
3 myocarditis 10.0
4 toxic myocarditis 10.0
5 hepatic encephalopathy 9.9 F2 GC
6 factor vii deficiency 9.8
7 aging 9.8
8 hepatic coma 9.8
9 spinal cord infarction 9.8 F2 F5
10 livedoid vasculopathy 9.8 F2 F5
11 sudden sensorineural hearing loss 9.8 F2 F5
12 cerebral sinovenous thrombosis 9.8 F2 F5
13 hemoglobin e disease 9.8 F2 F5
14 prothrombin deficiency, congenital 9.8 F2 F5
15 sagittal sinus thrombosis 9.8 F2 F5
16 ischemic colitis 9.8 F2 F5
17 cryptogenic cirrhosis 9.8 F2 F5
18 factor viii deficiency 9.8 F2 F5
19 sneddon syndrome 9.8 F2 F5
20 porencephaly 9.8 F2 F5
21 retinal artery occlusion 9.8 F2 F5
22 retinal vascular occlusion 9.8 F2 F5
23 thrombophlebitis 9.8 F2 F5
24 prothrombin deficiency 9.8 F2 F5
25 antithrombin iii deficiency 9.7 F2 F5
26 post-thrombotic syndrome 9.7 F2 F5
27 peripheral vertigo 9.7 F2 F5
28 central retinal vein occlusion 9.7 F2 F5
29 scott syndrome 9.7 F2 F5
30 portal vein thrombosis 9.7 F2 F5
31 patent foramen ovale 9.7 F2 F5
32 arteritic anterior ischemic optic neuropathy 9.7 F2 F5
33 dysfibrinogenemia 9.7 F2 F5
34 protein s deficiency 9.7 F2 F5
35 severe hemophilia a 9.7 F2 F5
36 vein disease 9.7 F2 F5
37 placental abruption 9.7 F2 F5
38 thrombasthenia 9.7 F2 F5
39 protein c deficiency 9.7 F2 F5
40 ischemic optic neuropathy 9.7 F2 F5
41 intracranial hypertension 9.7 F2 F5
42 retinal vein occlusion 9.7 F2 F5
43 blood coagulation disease 9.7 F2 F5
44 thrombophilia due to activated protein c resistance 9.7 F2 F5
45 factor x deficiency 9.7 F2 F5
46 nonarteritic anterior ischemic optic neuropathy 9.6 F2 F5
47 afibrinogenemia 9.6 F2 F5
48 von willebrand's disease 9.6 F2 F5
49 factor v deficiency 9.6 F2 F5
50 thrombophilia due to thrombin defect 9.6 F2 F5

Graphical network of the top 20 diseases related to Paracetamol Poisoning:



Diseases related to Paracetamol Poisoning

Symptoms & Phenotypes for Paracetamol Poisoning

Drugs & Therapeutics for Paracetamol Poisoning

Drugs for Paracetamol Poisoning (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 103-90-2 1983
2
Ondansetron Approved Phase 4 99614-02-5 4595
3
Acetylcysteine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 616-91-1 12035
4
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
5 Analgesics Phase 4,Phase 3,Phase 2,Not Applicable
6 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Not Applicable
7 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
8 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
9 Antipyretics Phase 4,Phase 3,Phase 2,Not Applicable
10 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
11 Respiratory System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
12 Central Nervous System Depressants Phase 4
13 Serotonin Agents Phase 4
14 Serotonin Antagonists Phase 4
15 Gastrointestinal Agents Phase 4
16 Neurotransmitter Agents Phase 4
17 N-monoacetylcystine Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18 Dermatologic Agents Phase 4
19 Tranquilizing Agents Phase 4
20 Anti-Anxiety Agents Phase 4
21 Emetics Phase 4
22 Expectorants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Antidotes Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
24 Antiemetics Phase 4
25 Antioxidants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
26 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
27 Antipruritics Phase 4
28 Antipsychotic Agents Phase 4
29 Psychotropic Drugs Phase 4
30 Autonomic Agents Phase 4
31 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3
32 Antibiotics, Antitubercular Phase 4,Phase 2
33
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
34 cysteine Nutraceutical Phase 4
35
Formaldehyde Approved, Vet_approved Phase 2, Phase 3 50-00-0 712
36 Pharmaceutical Solutions Phase 2, Phase 3,Phase 1
37 Liver Extracts Phase 3,Phase 2,Not Applicable
38 Antitubercular Agents Phase 2, Phase 3
39 dipyrone Phase 3
40
Phenylacetic acid Approved Phase 2 103-82-2 999
41
Isoniazid Approved, Investigational Phase 2 54-85-3 3767
42
Rifampicin Approved Phase 2 13292-46-1 5458213 5381226
43
Ethambutol Approved Phase 2 74-55-5 3279 14052
44
Pyrazinamide Approved, Investigational Phase 2 98-96-4 1046
45
Ornithine Approved, Nutraceutical Phase 2 70-26-8, 3184-13-2 6262
46 Antimetabolites Phase 2
47 Antimetabolites, Antineoplastic Phase 2
48 Cytochrome P-450 CYP3A Inducers Phase 2
49 Nucleic Acid Synthesis Inhibitors Phase 2
50 Hypolipidemic Agents Phase 2

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 Scottish and Newcastle Anti-emetic Pre-treatment for Paracetamol Poisoning Study (SNAP) Completed NCT01050270 Phase 4 Ondansetron;acetylcysteine;acetylcysteine
2 Protective Effects of Propylene Glycol in Daily Acetaminophen Dosing Completed NCT02322879 Phase 4 First Treatment Period;Second Treatment Period
3 A Pilot Study Investigating the Efficacy of Minocycline and N-Acetyl Cysteine for Bipolar Depression Recruiting NCT02719392 Phase 4 Minocycline
4 N-acetylcysteine in Non-Acetaminophen Pediatric Acute Liver Failure Completed NCT00248625 Phase 3 N-acetylcysteine;Placebo
5 A Trial Of Intravenous N-Acetylcysteine In The Management Of Antituberculous Drug-Induced Hepatitis Recruiting NCT02182167 Phase 2, Phase 3 IV N-acetylcysteine (NAC);Water
6 13C-Methacetin Breath Test for the Prediction of Outcome in in ALI or ALF Recruiting NCT02786836 Phase 2, Phase 3 13C-Methacetin
7 Paracetamol Toxicity in Septic Patients Suspended NCT01182974 Phase 3 paracetamol;dypirone
8 High-Dose N-Acetylcysteine in Cardiac Surgery Completed NCT00332631 Phase 2 N-acetylcysteine;Placebo
9 N-acetylcysteine in Intra-amniotic Infection/Inflammation Completed NCT00397735 Phase 1, Phase 2 N-acetylcysteine or placebo
10 Safety Study of Ornithine Phenylacetate to Treat Patients With Acute Liver Failure Completed NCT01548690 Phase 2 Ornithine phenylacetate
11 RIPE vs RIPE Plus N-acetylcysteine in Patients With HIV/TB Co-infection Recruiting NCT03281226 Phase 2 RIPE (2m) and RI (4m);RIPE+NAC (2m) and RI (4m)
12 A Study to Evaluate the Pharmacokinetics of Acetaminophen and Its Toxic Metabolites With 2 Formulations (Panadol and SafeTynadol) in Healthy Volunteers Completed NCT03451487 Phase 1 Panadol®;SafeTynadol®
13 Attempted Suicide With Acetaminophen Among 8-18 Year-old Children / Adolescents in Denmark Unknown status NCT01981213
14 Micro RNA-122 and the Clinical Course of Patients With Chronic Hepatitis C Unknown status NCT00980161
15 Adduct Dipstick for Diagnosis of Acetaminophen Toxicity Completed NCT01575847
16 Treatment of Acetaminophen Toxicity With N-acetylcysteine Completed NCT00725179
17 Treatment of APAP Toxicity With IV and Oral NAC 2008-2011 Completed NCT01465542
18 Cytokines Polymorphisms and Acetaminophen Toxicity Completed NCT00166608
19 Effect on Acetaminophen Metabolism by Liquid Formulations Completed NCT01246713 Not Applicable Acetaminophen liquid formulation;Acetaminophen solid formulation
20 N-acetylcysteine in Liver Transplantation Completed NCT00736541 Not Applicable N-acetylcysteine
21 A Multi-Center Group to Study Acute Liver Failure in Children Completed NCT00986648
22 Paracetamol Metabolism Research in Postoperative Hepatic Surgery Recruiting NCT03297073 Not Applicable paracetamol
23 Acetaminophen Biomarkers Enrolling by invitation NCT01005173
24 The Markers and Paracetamol Poisoning Study 2 Not yet recruiting NCT03497104

Search NIH Clinical Center for Paracetamol Poisoning

Genetic Tests for Paracetamol Poisoning

Anatomical Context for Paracetamol Poisoning

MalaCards organs/tissues related to Paracetamol Poisoning:

41
Liver, Testes, Heart

Publications for Paracetamol Poisoning

Articles related to Paracetamol Poisoning:

(show all 45)
# Title Authors Year
1
Increased risk of congestive heart failure in patients with acetaminophen poisoning: A nationwide cohort study. ( 29327353 )
2018
2
Retrospective study of paracetamol poisoning in children aged zero to six years found no cases of liver injury. ( 29577416 )
2018
3
Efficient diagnosis and treatment of acute paracetamol poisoning: cost-effectiveness analysis of approaches based on a hospital toxicovigilance program. ( 29687671 )
2018
4
Risk prediction of hepatotoxicity in paracetamol poisoning. ( 28447858 )
2017
5
Haemodialysis in acute paracetamol poisoning. ( 28096230 )
2017
6
Pharmacokinetic modelling of modified acetylcysteine infusion regimens used in the treatment of paracetamol poisoning. ( 28624886 )
2017
7
Increased availability of paracetamol in Sweden and incidence of paracetamol poisoning: using laboratory data to increase validity of a population-based registry study. ( 28083980 )
2017
8
The standard treatment protocol for paracetamol poisoning may be inadequate following overdose with modified release formulation: a pharmacokinetic and clinical analysis of 53 cases. ( 28644049 )
2017
9
Treatments for paracetamol poisoning. ( 27193197 )
2016
10
The 100 most influential publications in paracetamol poisoning treatment: a bibliometric analysis of human studies. ( 27652107 )
2016
11
A prospective observational study of a novel 2-phase infusion protocol for the administration of acetylcysteine in paracetamol poisoning. ( 26691690 )
2016
12
Simplification of the standard three-bag intravenous acetylcysteine regimen for paracetamol poisoning results in a lower incidence of adverse drug reactions. ( 26594846 )
2016
13
Intentional and accidental paracetamol poisoning in childhood - a retrospective analysis. ( 25897106 )
2015
14
Summary statement: new guidelines for the management of paracetamol poisoning in Australia and New Zealand. ( 26852051 )
2015
15
Disproportionate effect on child admissions of the change in Medicines and Healthcare Products Regulatory Agency guidance for management of paracetamol poisoning: an analysis of hospital admissions for paracetamol overdose in England and Scotland. ( 26353969 )
2015
16
Can AST/ALT ratio indicate recovery after acute paracetamol poisoning? The authors reply. ( 25815859 )
2015
17
Can AST/ALT ratio indicate recovery after acute paracetamol poisoning? ( 25652258 )
2015
18
Paracetamol poisoning: beyond the nomogram. ( 26099917 )
2015
19
Paracetamol poisoning in adolescents in an Australian setting: not quite adults. ( 25752743 )
2015
20
Changing the Management of Paracetamol Poisoning. ( 26233473 )
2015
21
Assessing the Effect of Leptin on Liver Damage in Case of Hepatic Injury Associated with Paracetamol Poisoning. ( 26697061 )
2015
22
Management of acute paracetamol poisoning. ( 26493077 )
2015
23
Limitations of AST/ALT ratio in paracetamol poisoning. ( 25811936 )
2015
24
Correction: New guidelines for the management of paracetamol poisoning in Australia and New Zealand. ( 26465689 )
2015
25
Effect of the UK's revised paracetamol poisoning management guidelines on admissions, adverse reactions and costs of treatment. ( 24666324 )
2014
26
Impact of reducing the threshold for acetylcysteine treatment in acute paracetamol poisoning: the recent United Kingdom experience. ( 25200454 )
2014
27
Paracetamol poisoning in the UK: a meeting report from Pharmacology 2013. ( 24524593 )
2014
28
Understanding lactic acidosis in paracetamol (acetaminophen) poisoning. ( 21143497 )
2011
29
Association between gastrointestinal manifestations following acetaminophen poisoning and outcome in 291 acetaminophen poisoning patients. ( 20333776 )
2010
30
Renal injury at first presentation as a predictor for poor outcome in severe paracetamol poisoning referred to a liver transplant unit. ( 18958458 )
2009
31
Paracetamol (acetaminophen) poisoning. ( 19450343 )
2007
32
[Effect of N-acetylcysteine on prothrombin index in patients with uncomplicated paracetamol poisoning]. ( 15518006 )
2004
33
[Liver albumin dialysis--application in acetaminophen poisoning]. ( 15521608 )
2004
34
Prothrombin time prolongation in paracetamol poisoning: a relevant marker of hepatic failure? ( 14686484 )
2003
35
Fulminant hepatic failure secondary to acetaminophen poisoning: a systematic review and meta-analysis of prognostic criteria determining the need for liver transplantation. ( 12545033 )
2003
36
Paracetamol poisoning unmasking factor VII deficiency. ( 11943961 )
2002
37
N-acetylcysteine for paracetamol poisoning: effect on prothrombin. ( 12387954 )
2002
38
Effect of acetylcysteine on prothrombin index in paracetamol poisoning without hepatocellular injury. ( 12387966 )
2002
39
Pancytopenia, hyperglycemia, shock, coma, rhabdomyolysis, and pancreatitis associated with acetaminophen poisoning. ( 11757993 )
2001
40
[Gc-globulin in paracetamol poisoning]. ( 8966827 )
1996
41
Factor V and factor VIII:V ratio as prognostic indicators in paracetamol poisoning. ( 7651041 )
1995
42
Toxic myocarditis in paracetamol poisoning. ( 3122934 )
1988
43
Paracetamol (acetaminophen) poisoning resulting in acute renal failure without hepatic coma. ( 3173602 )
1988
44
Toxic myocarditis in paracetamol poisoning. ( 3120894 )
1987
45
Letter: Risk of hepatic coma in paracetamol poisoning. ( 53523 )
1975

Variations for Paracetamol Poisoning

Expression for Paracetamol Poisoning

Search GEO for disease gene expression data for Paracetamol Poisoning.

Pathways for Paracetamol Poisoning

GO Terms for Paracetamol Poisoning

Cellular components related to Paracetamol Poisoning according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.16 F2 F5
2 extracellular space GO:0005615 9.13 F2 F5 GC
3 blood microparticle GO:0072562 8.62 F2 GC

Biological processes related to Paracetamol Poisoning according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.26 F2 F5
2 blood coagulation GO:0007596 9.16 F2 F5
3 ER to Golgi vesicle-mediated transport GO:0006888 8.96 F2 F5
4 hemostasis GO:0007599 8.62 F2 F5

Sources for Paracetamol Poisoning

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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