MCID: PRC051
MIFTS: 34

Paracetamol Poisoning

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Paracetamol Poisoning

MalaCards integrated aliases for Paracetamol Poisoning:

Name: Paracetamol Poisoning 59
Acetaminophen Poisoning 59

Classifications:



External Ids:

Orphanet 59 ORPHA464458

Summaries for Paracetamol Poisoning

MalaCards based summary : Paracetamol Poisoning, also known as acetaminophen poisoning, is related to coronary artery anomaly and acute liver failure. An important gene associated with Paracetamol Poisoning is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. The drugs Acetaminophen and Acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and skin.

Wikipedia : 76 Paracetamol poisoning, also known as acetaminophen poisoning, is caused by excessive use of the... more...

Related Diseases for Paracetamol Poisoning

Diseases related to Paracetamol Poisoning via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 coronary artery anomaly 29.5 F2 F5
2 acute liver failure 29.5 F2 F5 GC
3 asthma 10.2
4 metabolic acidosis 10.2
5 myocarditis 10.1
6 toxic myocarditis 10.1
7 infantile liver failure syndrome 1 10.1
8 analbuminemia 10.0 F2 GC
9 hepatic encephalopathy 10.0 F2 GC
10 cystic fibrosis 9.9
11 factor vii deficiency 9.9
12 hepatic coma 9.9
13 acute pancreatitis 9.9
14 pancreatitis 9.9
15 spinal cord infarction 9.9 F2 F5
16 sudden sensorineural hearing loss 9.9 F2 F5
17 cerebral sinovenous thrombosis 9.9 F2 F5
18 thrombosis 9.9 F2 F5
19 hemoglobin e disease 9.9 F2 F5
20 prothrombin deficiency, congenital 9.9 F2 F5
21 sagittal sinus thrombosis 9.9 F2 F5
22 cryptogenic cirrhosis 9.9 F2 F5
23 ischemic colitis 9.9 F2 F5
24 factor viii deficiency 9.9 F2 F5
25 porencephaly 9.9 F2 F5
26 retinal vascular occlusion 9.9 F2 F5
27 thrombophlebitis 9.9 F2 F5
28 gastroschisis 9.9 F2 F5
29 antithrombin iii deficiency 9.9 F2 F5
30 post-thrombotic syndrome 9.9 F2 F5
31 peripheral vertigo 9.9 F2 F5
32 central retinal vein occlusion 9.9 F2 F5
33 retinal vein occlusion 9.9 F2 F5
34 blood protein disease 9.9 F2 F5
35 retinal artery occlusion 9.9 F2 F5
36 portal vein thrombosis 9.9 F2 F5
37 pulmonary artery disease 9.9 F2 F5
38 dysfibrinogenemia 9.9 F2 F5
39 arteritic anterior ischemic optic neuropathy 9.9 F2 F5
40 arteries, anomalies of 9.9
41 congestive heart failure 9.9
42 pancytopenia 9.9
43 lactic acidosis 9.9
44 hyperglycemia 9.9
45 ischemic optic neuropathy 9.9 F2 F5
46 protein s deficiency 9.9 F2 F5
47 placental abruption 9.9 F2 F5
48 thrombasthenia 9.9 F2 F5
49 protein c deficiency 9.9 F2 F5
50 vein disease 9.9 F2 F5

Graphical network of the top 20 diseases related to Paracetamol Poisoning:



Diseases related to Paracetamol Poisoning

Symptoms & Phenotypes for Paracetamol Poisoning

Drugs & Therapeutics for Paracetamol Poisoning

Drugs for Paracetamol Poisoning (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 103-90-2 1983
2
Acetylcysteine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 616-91-1 12035
3
Ondansetron Approved Phase 4 99614-02-5 4595
4
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
5 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
6 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
7 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
8 Antipyretics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
9 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
10 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
11 Antidotes Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
12 Emetics Phase 4
13 Serotonin Agents Phase 4
14 Antipsychotic Agents Phase 4
15 Antiemetics Phase 4
16 Antipruritics Phase 4
17 Serotonin Antagonists Phase 4
18 Gastrointestinal Agents Phase 4
19 Antioxidants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
20 Expectorants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
21 N-monoacetylcystine Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Anti-Anxiety Agents Phase 4
23 Tranquilizing Agents Phase 4
24 Free Radical Scavengers Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
25 Respiratory System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
26 Psychotropic Drugs Phase 4
27 Central Nervous System Depressants Phase 4
28 Neurotransmitter Agents Phase 4
29 Autonomic Agents Phase 4
30 Dermatologic Agents Phase 4
31 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
32 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3
33 Antibiotics, Antitubercular Phase 4,Phase 2
34 cysteine Phase 4
35
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
36
Formaldehyde Approved, Vet_approved Phase 2, Phase 3 50-00-0 712
37 Liver Extracts Phase 3,Phase 2,Phase 1,Not Applicable
38 Pharmaceutical Solutions Phase 2, Phase 3,Phase 1
39 Antitubercular Agents Phase 2, Phase 3
40 dipyrone Phase 3
41
Phenylacetic acid Approved Phase 2 103-82-2 999
42
Isoniazid Approved, Investigational Phase 2 54-85-3 3767
43
Pyrazinamide Approved, Investigational Phase 2 98-96-4 1046
44
Rifampicin Approved Phase 2 13292-46-1 5458213 5381226
45
Ethambutol Approved Phase 2 74-55-5 3279 14052
46
Ornithine Approved, Nutraceutical Phase 2 3184-13-2, 70-26-8 6262
47 Antimetabolites Phase 2
48 Antimetabolites, Antineoplastic Phase 2
49 Lipid Regulating Agents Phase 2
50 Cytochrome P-450 CYP3A Inducers Phase 2

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Scottish and Newcastle Anti-emetic Pre-treatment for Paracetamol Poisoning Study (SNAP) Completed NCT01050270 Phase 4 Ondansetron;acetylcysteine;acetylcysteine
2 Protective Effects of Propylene Glycol in Daily Acetaminophen Dosing Completed NCT02322879 Phase 4 First Treatment Period;Second Treatment Period
3 A Pilot Study Investigating the Efficacy of Minocycline and N-Acetyl Cysteine for Bipolar Depression Recruiting NCT02719392 Phase 4 Minocycline
4 N-acetylcysteine in Non-Acetaminophen Pediatric Acute Liver Failure Completed NCT00248625 Phase 3 N-acetylcysteine;Placebo
5 A Trial Of Intravenous N-Acetylcysteine In The Management Of Antituberculous Drug-Induced Hepatitis Recruiting NCT02182167 Phase 2, Phase 3 IV N-acetylcysteine (NAC);Water
6 13C-Methacetin Breath Test for the Prediction of Outcome in in ALI or ALF Recruiting NCT02786836 Phase 2, Phase 3 13C-Methacetin
7 Paracetamol Toxicity in Septic Patients Suspended NCT01182974 Phase 3 paracetamol;dypirone
8 High-Dose N-Acetylcysteine in Cardiac Surgery Completed NCT00332631 Phase 2 N-acetylcysteine;Placebo
9 N-acetylcysteine in Intra-amniotic Infection/Inflammation Completed NCT00397735 Phase 1, Phase 2 N-acetylcysteine or placebo
10 Safety Study of Ornithine Phenylacetate to Treat Patients With Acute Liver Failure/Severe Acute Liver Injury Completed NCT01548690 Phase 2 Ornithine Phenylacetate
11 RIPE vs RIPE Plus N-acetylcysteine in Patients With HIV/TB Co-infection Recruiting NCT03281226 Phase 2 RIPE (2m) and RI (4m);RIPE+NAC (2m) and RI (4m)
12 A Study to Evaluate the Pharmacokinetics of Acetaminophen and Its Toxic Metabolites With 2 Formulations (Panadol and SafeTynadol) in Healthy Volunteers Completed NCT03451487 Phase 1 Panadol®;SafeTynadol®
13 Attempted Suicide With Acetaminophen Among 8-18 Year-old Children / Adolescents in Denmark Unknown status NCT01981213
14 Micro RNA-122 and the Clinical Course of Patients With Chronic Hepatitis C Unknown status NCT00980161
15 Adduct Dipstick for Diagnosis of Acetaminophen Toxicity Completed NCT01575847
16 Treatment of Acetaminophen Toxicity With N-acetylcysteine Completed NCT00725179
17 Treatment of APAP Toxicity With IV and Oral NAC 2008-2011 Completed NCT01465542
18 Cytokines Polymorphisms and Acetaminophen Toxicity Completed NCT00166608
19 Effect on Acetaminophen Metabolism by Liquid Formulations Completed NCT01246713 Not Applicable Acetaminophen liquid formulation;Acetaminophen solid formulation
20 N-acetylcysteine in Liver Transplantation Completed NCT00736541 Not Applicable N-acetylcysteine
21 A Multi-Center Group to Study Acute Liver Failure in Children Completed NCT00986648
22 The Markers and Paracetamol Poisoning Study 2 Recruiting NCT03497104
23 APAP Hepatotoxicity After Therapeutic Doses Recruiting NCT03602274
24 Paracetamol Metabolism Research in Postoperative Hepatic Surgery Recruiting NCT03297073 Not Applicable paracetamol
25 Acetaminophen Biomarkers Enrolling by invitation NCT01005173

Search NIH Clinical Center for Paracetamol Poisoning

Genetic Tests for Paracetamol Poisoning

Anatomical Context for Paracetamol Poisoning

MalaCards organs/tissues related to Paracetamol Poisoning:

41
Liver, Kidney, Skin, Heart, Testes, Colon, Spinal Cord

Publications for Paracetamol Poisoning

Articles related to Paracetamol Poisoning:

(show top 50) (show all 352)
# Title Authors Year
1
In response to: "Pharmacokinetic modelling of modified acetylcysteine infusion regimens used in the treatment of paracetamol poisoning". ( 29159489 )
2018
2
Increased risk of congestive heart failure in patients with acetaminophen poisoning: A nationwide cohort study. ( 29327353 )
2018
3
Retrospective study of paracetamol poisoning in children aged zero to six years found no cases of liver injury. ( 29577416 )
2018
4
The standard treatment protocol for paracetamol poisoning may be inadequate following overdose with modified release formulation: a pharmacokinetic and clinical analysis of 53 cases. ( 28644049 )
2018
5
Efficient diagnosis and treatment of acute paracetamol poisoning: cost-effectiveness analysis of approaches based on a hospital toxicovigilance program. ( 29687671 )
2018
6
Pattern of Paracetamol Poisoning: Influence on Outcome and Complications. ( 30274302 )
2018
7
Acetaminophen Poisoning May Increase Coronary Artery Disease Risk: A Nationwide Cohort Study. ( 29302859 )
2018
8
Long-term mortality of acetaminophen poisoning: a nationwide population-based cohort study with 10-year follow-up in Taiwan. ( 29310687 )
2018
9
Anaphylactoid Reactions to Intravenous N-Acetylcysteine during Treatment for Acetaminophen Poisoning. ( 29423816 )
2018
10
Correction to: Anaphylactoid Reactions to Intravenous N-Acetylcysteine during Treatment for Acetaminophen Poisoning. ( 29532341 )
2018
11
Acetaminophen Poisoning. ( 29858299 )
2018
12
Risk prediction of hepatotoxicity in paracetamol poisoning. ( 28447858 )
2017
13
Haemodialysis in acute paracetamol poisoning. ( 28096230 )
2017
14
Pharmacokinetic modelling of modified acetylcysteine infusion regimens used in the treatment of paracetamol poisoning. ( 28624886 )
2017
15
Increased availability of paracetamol in Sweden and incidence of paracetamol poisoning: using laboratory data to increase validity of a population-based registry study. ( 28083980 )
2017
16
Novel Regimens in the Treatment of Paracetamol (Acetaminophen) Poisoning. ( 29322714 )
2017
17
Treatments for paracetamol poisoning. ( 27193197 )
2016
18
The 100 most influential publications in paracetamol poisoning treatment: a bibliometric analysis of human studies. ( 27652107 )
2016
19
A prospective observational study of a novel 2-phase infusion protocol for the administration of acetylcysteine in paracetamol poisoning. ( 26691690 )
2016
20
Simplification of the standard three-bag intravenous acetylcysteine regimen for paracetamol poisoning results in a lower incidence of adverse drug reactions. ( 26594846 )
2016
21
Hepatotoxicity in Obese Versus Nonobese Patients With Acetaminophen Poisoning Who Are Treated With Intravenous N-Acetylcysteine. ( 24263163 )
2016
22
Intentional and accidental paracetamol poisoning in childhood - a retrospective analysis. ( 25897106 )
2015
23
Summary statement: new guidelines for the management of paracetamol poisoning in Australia and New Zealand. ( 26852051 )
2015
24
Disproportionate effect on child admissions of the change in Medicines and Healthcare Products Regulatory Agency guidance for management of paracetamol poisoning: an analysis of hospital admissions for paracetamol overdose in England and Scotland. ( 26353969 )
2015
25
Can AST/ALT ratio indicate recovery after acute paracetamol poisoning? The authors reply. ( 25815859 )
2015
26
Can AST/ALT ratio indicate recovery after acute paracetamol poisoning? ( 25652258 )
2015
27
Paracetamol poisoning: beyond the nomogram. ( 26099917 )
2015
28
Paracetamol poisoning in adolescents in an Australian setting: not quite adults. ( 25752743 )
2015
29
Changing the Management of Paracetamol Poisoning. ( 26233473 )
2015
30
Assessing the Effect of Leptin on Liver Damage in Case of Hepatic Injury Associated with Paracetamol Poisoning. ( 26697061 )
2015
31
Management of acute paracetamol poisoning. ( 26493077 )
2015
32
Limitations of AST/ALT ratio in paracetamol poisoning. ( 25811936 )
2015
33
Correction: New guidelines for the management of paracetamol poisoning in Australia and New Zealand. ( 26465689 )
2015
34
Acute Liver Failure Due to Acetaminophen Poisoning in Patients With Prior Weight Loss Surgery: A Case Series. ( 25551211 )
2015
35
Epidemiology, management and outcome of paracetamol poisoning in an inner city emergency department. ( 24099830 )
2015
36
Worldwide research productivity of paracetamol (acetaminophen) poisoning: a bibliometric analysis (2003-2012). ( 24758786 )
2015
37
N-acetylcysteine overdose after acetaminophen poisoning. ( 25767408 )
2015
38
Aminotriazole alleviates acetaminophen poisoning via downregulating P450 2E1 and suppressing inflammation. ( 25884831 )
2015
39
Challenges with AST/ALT ratio in acetaminophen poisoning--the authors reply. ( 25994369 )
2015
40
Acetaminophen Poisoning and Risk of Acute Pancreatitis: A Population-Based Cohort Study. ( 26200631 )
2015
41
Challenges with AST/ALT ratio in acetaminophen poisoning. ( 26216665 )
2015
42
Paracetamol (acetaminophen) poisoning. ( 26479248 )
2015
43
Effect of the UK's revised paracetamol poisoning management guidelines on admissions, adverse reactions and costs of treatment. ( 24666324 )
2014
44
Impact of reducing the threshold for acetylcysteine treatment in acute paracetamol poisoning: the recent United Kingdom experience. ( 25200454 )
2014
45
Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial. ( 24290406 )
2014
46
Paracetamol poisoning in the UK: a meeting report from Pharmacology 2013. ( 24524593 )
2014
47
A single-arm clinical trial of a 48-hour intravenous N-acetylcysteine protocol for treatment of acetaminophen poisoning. ( 24708414 )
2014
48
Liver transplantation in case of acetaminophen poisoning: importance of assessment of the colon if arterial lactate increases despite appropriate care. ( 25022235 )
2014
49
Extracorporeal treatment for acetaminophen poisoning: recommendations from the EXTRIP workgroup. ( 25133498 )
2014
50
Introduction of an N-acetylcysteine weight-based dosing chart reduces prescription errors in the treatment of paracetamol poisoning. ( 23379449 )
2013

Variations for Paracetamol Poisoning

Expression for Paracetamol Poisoning

Search GEO for disease gene expression data for Paracetamol Poisoning.

Pathways for Paracetamol Poisoning

GO Terms for Paracetamol Poisoning

Cellular components related to Paracetamol Poisoning according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.16 F2 F5
2 extracellular space GO:0005615 9.13 F2 F5 GC
3 blood microparticle GO:0072562 8.62 F2 GC

Biological processes related to Paracetamol Poisoning according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.26 F2 F5
2 ER to Golgi vesicle-mediated transport GO:0006888 9.16 F2 F5
3 blood coagulation GO:0007596 8.96 F2 F5
4 hemostasis GO:0007599 8.62 F2 F5

Sources for Paracetamol Poisoning

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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