MCID: PRC002
MIFTS: 58

Paracoccidioidomycosis

Categories: Rare diseases, Infectious diseases, Bone diseases, Respiratory diseases, Immune diseases

Aliases & Classifications for Paracoccidioidomycosis

MalaCards integrated aliases for Paracoccidioidomycosis:

Name: Paracoccidioidomycosis 12 76 53 59 55 44 15 73
Mucocutaneous-Lymphangitic Paracoccidioidomycosis 12
Lutz-Splendore-Almeida Disease 53
South American Blastomycosis 53
Paracoccidioidal Granuloma 53
Paracoccidioidal Mycosis 12
Lobo Disease 53
Lobomycosis 73
Pcm 53

Characteristics:

Orphanet epidemiological data:

59
paracoccidioidomycosis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:12662
ICD10 33 B41 B41.9
ICD9CM 35 116.1
MeSH 44 D010229
NCIt 50 C34891
Orphanet 59 ORPHA73260
ICD10 via Orphanet 34 B41.8 B41.9 B41.0 more
MESH via Orphanet 45 D010229
UMLS via Orphanet 74 C0030409
UMLS 73 C0030409

Summaries for Paracoccidioidomycosis

Disease Ontology : 12 A primary systemic mycosis that results in systemic fungal infection located in mucosa, located in lymph nodes, located in bone, located in skin or located in lungs, has material basis in Paracoccidioides brasiliensis.

MalaCards based summary : Paracoccidioidomycosis, also known as mucocutaneous-lymphangitic paracoccidioidomycosis, is related to laryngitis and osteomyelitis. An important gene associated with Paracoccidioidomycosis is IL10 (Interleukin 10), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include mucosa, lymph nodes and bone, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 Paracoccidioidomycosis (PCM) (also known as \"Brazilian blastomycosis\", \"South American... more...

Related Diseases for Paracoccidioidomycosis

Diseases related to Paracoccidioidomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 379)
# Related Disease Score Top Affiliating Genes
1 laryngitis 30.2 IL6 TNF
2 osteomyelitis 29.9 IFNG IL6 TNF
3 gingivitis 29.8 IL4 IL6 TNF
4 lung disease 29.6 IL10 IL5 TLR2 TNF
5 crohn's disease 29.2 IL10 IL6 TLR4 TNF
6 peritonitis 29.0 IL10 IL6 TLR2 TNF
7 penicilliosis 29.0 CD86 TLR2 TLR4 TNF
8 prostatitis 28.7 IL10 IL2 IL6 TNF
9 arthritis 28.4 IFNG IL10 IL18 IL6 TNF
10 acquired immunodeficiency syndrome 28.3 IFNG IL10 IL2 IL6 TNF
11 schistosomiasis 27.7 IFNG IL10 IL2 IL4 IL5 TNF
12 pneumonia 27.5 IL10 IL5 IL6 TLR2 TLR4 TNF
13 pulmonary tuberculosis 27.1 IFNG IL10 IL18 IL2 IL4 TLR2
14 periodontitis 27.0 IFNG IL10 IL4 IL6 TLR2 TLR4
15 multiple sclerosis 24.8 CD86 CTLA4 CXCL10 IFNG IL10 IL2
16 systemic lupus erythematosus 24.5 CD86 CTLA4 CXCL10 IFNG IL10 IL18
17 rheumatoid arthritis 23.4 CD86 CTLA4 IFNG IL10 IL18 IL2
18 punctate inner choroidopathy 10.9 IL10 TNF
19 microscopic polyangiitis 10.9 IL10 TNF
20 multifocal choroiditis 10.9 IL10 TNF
21 transient hypogammaglobulinemia 10.8 IL10 TNF
22 staphylococcal toxic shock syndrome 10.8 IFNG TNF
23 sporotrichosis 10.8 IFNG IL10
24 mycoplasmal pneumonia 10.8 IFNG IL4
25 trichosporonosis 10.8 IFNG TNF
26 choroiditis 10.8 IL10 TNF
27 chronic beryllium disease 10.8 IFNG TNF
28 autoimmune pancreatitis 10.8 CTLA4 TNF
29 immunoglobulin a deficiency 1 10.8 IL10 IL4
30 eosinophilic fasciitis 10.7 IFNG IL5
31 idiopathic achalasia 10.7 IL10 TNF
32 retinitis pigmentosa 22 10.7 IL10 IL4
33 trichuriasis 10.7 IL10 TNF
34 necatoriasis 10.7 IL10 IL5
35 penicillin allergy 10.7 IFNG IL4
36 mucocutaneous leishmaniasis 10.7 IL10 TNF
37 aseptic meningitis 10.6 IFNG IL10 TNF
38 tropical endomyocardial fibrosis 10.6 IL10 IL4 TNF
39 cardiac sarcoidosis 10.6 IL5 TNF
40 severe hemophilia a 10.6 CTLA4 IL10 TNF
41 tungiasis 10.6 IL10 IL4 TNF
42 endomyocardial fibrosis 10.6 IL10 IL4 TNF
43 chronic graft versus host disease 10.6 IFNG IL10
44 hyperlucent lung 10.6 IFNG IL10 IL4
45 cough variant asthma 10.6 IL4 IL5
46 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.6 CTLA4 IFNG IL10
47 peanut allergy 10.6 CXCL10 IFNG IL10
48 baylisascariasis 10.6 IFNG IL10 IL4
49 rheumatic disease 10.6 IFNG IL10 TNF
50 primary peritoneal carcinoma 10.6 CXCL10 IFNG IL10

Graphical network of the top 20 diseases related to Paracoccidioidomycosis:



Diseases related to Paracoccidioidomycosis

Symptoms & Phenotypes for Paracoccidioidomycosis

MGI Mouse Phenotypes related to Paracoccidioidomycosis:

46 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.34 IL10 CXCL10 IFNG CD86 CTLA4 IL2
2 homeostasis/metabolism MP:0005376 10.32 CTLA4 CXCL10 IL10 CD86 IFNG IL4
3 cellular MP:0005384 10.31 CXCL10 IL10 CD86 IFNG IL4 IL2
4 immune system MP:0005387 10.31 CTLA4 IL10 CXCL10 IFNG CD86 IL2
5 digestive/alimentary MP:0005381 10.3 IL10 IFNG CTLA4 IL2 IL5 IL4
6 behavior/neurological MP:0005386 10.28 IFNG CD86 IL18 IL10 IL2 IL6
7 cardiovascular system MP:0005385 10.27 CTLA4 CXCL10 IL10 IFNG IL18 IL2
8 growth/size/body region MP:0005378 10.24 IFNG IL4 IL18 IL10 IL2 IL6
9 endocrine/exocrine gland MP:0005379 10.2 CTLA4 CD86 IFNG IL4 IL10 IL2
10 mortality/aging MP:0010768 10.17 IFNG CTLA4 CXCL10 IL4 IL18 IL10
11 liver/biliary system MP:0005370 10.16 CTLA4 IL10 IFNG IL2 IL5 IL4
12 integument MP:0010771 10.13 CTLA4 IL10 IFNG IL18 IL4 IL6
13 nervous system MP:0003631 10.02 IFNG CXCL10 CD86 IL4 IL18 IL10
14 muscle MP:0005369 10.01 IL10 CD86 IFNG IL18 IL6 TLR4
15 neoplasm MP:0002006 9.97 IL10 IFNG IL2 TLR4 IL5 TLR2
16 reproductive system MP:0005389 9.86 IFNG IL4 IL10 IL2 IL6 IL5
17 respiratory system MP:0005388 9.85 CTLA4 IL10 IFNG IL2 IL5 IL4
18 skeleton MP:0005390 9.56 IFNG CTLA4 IL4 IL10 IL6 TLR2
19 vision/eye MP:0005391 9.23 IFNG IL18 IL4 IL10 IL2 IL6

Drugs & Therapeutics for Paracoccidioidomycosis

Search Clinical Trials , NIH Clinical Center for Paracoccidioidomycosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: paracoccidioidomycosis

Genetic Tests for Paracoccidioidomycosis

Anatomical Context for Paracoccidioidomycosis

The Foundational Model of Anatomy Ontology organs/tissues related to Paracoccidioidomycosis:

19
Mucosa, Lymph Nodes, Bone, Skin Or

MalaCards organs/tissues related to Paracoccidioidomycosis:

41
Bone, Lung, Skin, Lymph Node, T Cells, Testes, Monocytes

Publications for Paracoccidioidomycosis

Articles related to Paracoccidioidomycosis:

(show top 50) (show all 647)
# Title Authors Year
1
Pulmonary paracoccidioidomycosis associated with the use of natalizumab in multiple sclerosis. ( 29649930 )
2018
2
Intestinal paracoccidioidomycosis resembling Crohn's disease in a teenager: a case report. ( 29706133 )
2018
3
Case Report: Misleading Serological Diagnosis of Paracoccidioidomycosis in a Young Patient with the Acute Form Disease:<i>Paracoccidioides brasiliensis</i>or<i>Paracoccidioides lutzii</i>? ( 29405111 )
2018
4
67Ga Scintigraphy for Assessment of Disease Severity and Treatment Response in Patients With Paracoccidioidomycosis. ( 29517539 )
2018
5
Paracoccidioidomycosis due to Paracoccidioides brasiliensis S1 plus HIV co-infection. ( 29412355 )
2018
6
Diagnosis and Treatment of Paracoccidioidomycosis in the Maxillofacial Region: A Report of 5 Cases. ( 29850333 )
2018
7
Paracoccidioidomycosis diagnosed in bone marrow biopsy: indicative of fungemia and unfavorable prognois. ( 29944929 )
2018
8
Paracoccidioidomycosis simulating Crohn's disease. ( 29746902 )
2018
9
Unusual Intestinal Involvement by Paracoccidioidomycosis Diagnosed After Oral Manifestation. ( 29453699 )
2018
10
Paracoccidioidomycosis: Detection of Paracoccidioides brasiliensisA' genome in biological samples by quantitative chain reaction polymerase (qPCR). ( 29803846 )
2018
11
Geographical evaluation of Neuroparacoccidioidomycosis and Paracoccidioidomycosis in Southern Brazil. ( 29663530 )
2018
12
Scrotal swelling in a farmworker with paracoccidioidomycosis. ( 29551333 )
2018
13
Emergence of acute/subacute infant-juvenile paracoccidioidomycosis in Northeast Argentina: Effect of climatic and anthropogenic changes? ( 29346653 )
2018
14
A case of paracoccidioidomycosis due to<i>Paracoccidioides lutzii</i>presenting sarcoid-like form. ( 29159027 )
2018
15
Imaging paracoccidioidomycosis: A pictorial review from head to toe. ( 29685479 )
2018
16
Sarcoid-Like Paracoccidioidomycosis in a Female Urban Dweller: Reviewing a Rare Clinical Condition in Brazil. ( 29737451 )
2018
17
Estrogen Receptor-I+ Correlates with Higher Fungal Cell Number in Oral Paracoccidioidomycosis in Women. ( 29796757 )
2018
18
A multicentre study of oral paracoccidioidomycosis: analysis of 320 cases and literature review. ( 29949225 )
2018
19
Disseminated paracoccidioidomycosis prediagnosticated as neoplasm: An important challenge in diagnosis using rt-PCR. ( 29071205 )
2018
20
Pulmonary paracoccidioidomycosis: a case report of reactivation in a patient receiving biological therapy. ( 29768566 )
2018
21
Potential of the association of dodecyl gallate with nanostructured lipid system as a treatment for paracoccidioidomycosis: In vitro and in vivo efficacy and toxicity. ( 29883792 )
2018
22
67Ga Scintigraphy for Assessment of Disease Severity and Treatment Response in Patients With Paracoccidioidomycosis: Erratum. ( 29688954 )
2018
23
Notch Signaling is Required for Dendritic Cell Maturation and T Cell Expansion in Paracoccidioidomycosis. ( 29911286 )
2018
24
Chronic Multifocal Paracoccidioidomycosis: Pulmonary and Cutaneous Involvement. ( 29793811 )
2018
25
Itraconazole in combination with neutrophil depletion reduces the expression of genes related to pulmonary fibrosis in an experimental model of paracoccidioidomycosis. ( 29420794 )
2017
26
Th1-Inducing Agents in Prophylaxis and Therapy for Paracoccidioidomycosis. ( 28584990 )
2017
27
Acute Paracoccidioidomycosis in a 40-Year-Old Man: A Case Report and Literature Review. ( 28900882 )
2017
28
Paracoccidioidomycosis: level of pulmonary sequelae in high resolution computed tomography images from patients of two endemic regions of Brazil. ( 28811998 )
2017
29
Therapeutic treatment with scFv-PLGA nanoparticles decreases pulmonary fungal load in a murine model of paracoccidioidomycosis. ( 28951317 )
2017
30
Bone marrow-derived mesenchymal stem cells transplantation alters the course of experimental paracoccidioidomycosis by exacerbating the chronic pulmonary inflammatory response. ( 29253200 )
2017
31
Paracoccidioidomycosis with sarcoid-like lesions:a diagnostic challenge. ( 28562770 )
2017
32
DNAhsp65 Vaccine as Therapy against Paracoccidioidomycosis. ( 28584985 )
2017
33
Hypereosinophilia Secondary to Disseminated Paracoccidioidomycosis. ( 29042530 )
2017
34
Paracoccidioidomycosis: Epidemiological and Clinical Aspects in 546 Cases Studied in the State of EspA-rito Santo, Brazil. ( 28749757 )
2017
35
New Trends in Paracoccidioidomycosis Epidemiology. ( 29371520 )
2017
36
Paracoccidioidomycosis ceti in an Atlantic bottlenose dolphin (Tursiops truncatus), Brazil. ( 29205896 )
2017
37
Altered distribution of peripheral blood dendritic cell subsets in patients with pulmonary paracoccidioidomycosis. ( 28606816 )
2017
38
Impaired anti-fibrotic effect of bone marrow-derived mesenchymal stem cell in a mouse model of pulmonary paracoccidioidomycosis. ( 29040281 )
2017
39
Ophthalmic Paracoccidioidomycosis. ( 29187269 )
2017
40
Hepatic Disease with Portal Hypertension and Acute Juvenile Paracoccidioidomycosis: A Report of Two Cases and Literature Review. ( 28577123 )
2017
41
Spontaneous pneumothorax in paracoccidioidomycosis patients from an endemic area in Midwestern Brazil. ( 27687259 )
2017
42
Peptide Vaccine Against Paracoccidioidomycosis. ( 28584987 )
2017
43
Brazilian guidelines for the clinical management of paracoccidioidomycosis. ( 28746570 )
2017
44
Voice disorders in residual paracoccidioidomycosis in upper airways and digestive tract. ( 28583268 )
2017
45
Oral paracoccidioidomycosis in a single-center retrospective analysis from a Brazilian southeastern population. ( 29153538 )
2017
46
Th17-Inducing Cytokines IL-6 and IL-23 Are Crucial for Granuloma Formation during Experimental Paracoccidioidomycosis. ( 28871251 )
2017
47
Standardization and Prevalence of the Booster Phenomenon: Evaluation Using a Two-Step Skin Test with 43A kDa Glycoprotein in Individuals from an Endemic Region of Paracoccidioidomycosis. ( 28646277 )
2017
48
NOD-Like Receptor P3 Inflammasome Controls Protective Th1/Th17 Immunity against Pulmonary Paracoccidioidomycosis. ( 28740491 )
2017
49
Increased peripheral blood TCD4+ counts and serum SP-D levels in patients with chronic paracoccidioidomycosis, during and after antifungal therapy. ( 29091134 )
2017
50
Autopsy and biopsy study of paracoccidioidomycosis and neuroparacoccidioidomycosis with and without HIV co-infection. ( 29274088 )
2017

Variations for Paracoccidioidomycosis

Expression for Paracoccidioidomycosis

Search GEO for disease gene expression data for Paracoccidioidomycosis.

Pathways for Paracoccidioidomycosis

Pathways related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 CD86 CTLA4 CXCL10 IFNG IL10 IL18
2
Show member pathways
13.82 CXCL10 IL10 IL18 IL2 IL4 IL5
3
Show member pathways
13.71 CXCL10 IFNG IL10 IL18 IL2 IL4
4
Show member pathways
13.54 IFNG IL10 IL18 IL2 IL4 IL5
5
Show member pathways
13.49 CXCL10 IL10 IL18 IL2 IL4 IL5
6
Show member pathways
13.44 CD86 CXCL10 IFNG IL10 IL18 IL2
7
Show member pathways
13.35 CXCL10 IL10 IL18 IL2 IL4 IL5
8
Show member pathways
13.06 CD86 CXCL10 IFNG IL10 IL18 IL2
9
Show member pathways
13.02 IL2 IL4 IL6 TLR2 TLR4 TNF
10
Show member pathways
12.92 CD86 CTLA4 IFNG IL10 IL18 IL2
11
Show member pathways
12.89 CXCL10 IFNG IL18 IL2 IL4 IL6
12 12.86 IFNG IL2 IL4 IL5 IL6
13
Show member pathways
12.86 IFNG IL2 IL4 TLR2 TLR4 TNF
14
Show member pathways
12.84 CXCL10 IFNG IL18 IL6 TLR4 TNF
15
Show member pathways
12.76 IFNG IL10 IL18 IL2 IL4 IL5
16
Show member pathways
12.74 IL2 IL6 TLR2 TLR4 TNF
17
Show member pathways
12.69 IFNG IL10 IL18 IL2 IL6 TNF
18 12.69 CTLA4 CXCL10 IFNG IL10 IL2 IL4
19
Show member pathways
12.63 CD86 IL6 TLR2 TLR4 TNF
20
Show member pathways
12.55 CTLA4 IFNG IL10 IL2 IL4 IL5
21
Show member pathways
12.52 IFNG IL2 IL4 TNF
22
Show member pathways
12.49 CXCL10 IFNG IL4 IL5 IL6 TLR2
23
Show member pathways
12.42 IFNG IL2 IL4 IL6 TNF
24
Show member pathways
12.4 IFNG IL10 IL4 TLR2 TLR4 TNF
25 12.4 IFNG IL10 IL18 IL6 TLR2 TLR4
26
Show member pathways
12.38 IFNG IL10 IL18 IL2 IL4 IL5
27
Show member pathways
12.33 CXCL10 IFNG IL4 IL6 TLR2 TLR4
28
Show member pathways
12.32 IFNG IL6 TLR4 TNF
29
Show member pathways
12.31 IL6 TLR2 TLR4 TNF
30 12.3 IFNG IL6 TLR2 TLR4 TNF
31
Show member pathways
12.28 IL18 IL6 TLR2 TNF
32
Show member pathways
12.27 IL10 IL2 IL6 TNF
33
Show member pathways
12.22 IFNG IL10 IL18 IL2 IL4 IL5
34 12.15 CXCL10 IFNG IL2 IL4 IL6 TLR4
35 12.12 IL10 IL18 IL4 IL6 TNF
36
Show member pathways
12.11 IL2 IL5 TLR2 TLR4
37
Show member pathways
12.08 CD86 IFNG IL10 IL18 IL2 IL6
38
Show member pathways
12.07 IFNG IL18 IL2 IL4
39 12.07 IFNG IL10 IL6 TLR2 TLR4 TNF
40 12.07 CD86 IFNG IL10 IL2 IL4 IL5
41 11.99 IL4 IL5 IL6 TNF
42 11.97 IFNG IL10 IL2 IL6
43 11.97 IFNG IL2 IL4 IL5 IL6
44 11.95 CXCL10 IL6 TNF
45 11.94 IFNG IL18 IL6 TLR4
46
Show member pathways
11.94 CTLA4 IFNG IL2 IL4 IL5 TNF
47 11.92 IFNG IL6 TLR4
48 11.92 IFNG IL10 IL2 IL6 TNF
49 11.89 IL18 IL2 TLR4
50 11.88 IL10 IL6 TLR4 TNF

GO Terms for Paracoccidioidomycosis

Cellular components related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 CXCL10 IFNG IL10 IL18 IL2 IL4
2 external side of plasma membrane GO:0009897 9.35 CD86 CTLA4 CXCL10 TLR4 TNF
3 extracellular space GO:0005615 9.28 CXCL10 IFNG IL10 IL18 IL2 IL4

Biological processes related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.97 CXCL10 IL10 TLR2 TLR4
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.94 IL6 TLR2 TLR4 TNF
3 positive regulation of DNA binding transcription factor activity GO:0051091 9.92 IL10 IL5 IL6 TNF
4 response to virus GO:0009615 9.9 CXCL10 IFNG TNF
5 defense response to Gram-positive bacterium GO:0050830 9.9 IL6 TLR2 TNF
6 positive regulation of inflammatory response GO:0050729 9.88 IL18 IL2 TLR2 TLR4
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.88 IFNG IL18 IL2 IL6
8 response to glucocorticoid GO:0051384 9.86 IL10 IL6 TNF
9 positive regulation of T cell proliferation GO:0042102 9.86 CD86 IL2 IL4 IL6
10 inflammatory response GO:0006954 9.86 CXCL10 IL10 IL18 IL5 IL6 TLR2
11 humoral immune response GO:0006959 9.85 IFNG IL6 TNF
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.85 IL18 IL6 TNF
13 positive regulation of interleukin-6 production GO:0032755 9.84 IL6 TLR2 TLR4 TNF
14 positive regulation of nitric oxide biosynthetic process GO:0045429 9.83 IFNG TLR4 TNF
15 negative regulation of T cell proliferation GO:0042130 9.83 CD86 CTLA4 IL10
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.83 IL18 TLR2 TLR4 TNF
17 positive regulation of interleukin-8 production GO:0032757 9.81 TLR2 TLR4 TNF
18 positive regulation of interferon-gamma production GO:0032729 9.81 IL18 IL2 TLR4 TNF
19 regulation of signaling receptor activity GO:0010469 9.81 CXCL10 IFNG IL10 IL18 IL2 IL4
20 negative regulation of interleukin-6 production GO:0032715 9.8 IL10 TLR4 TNF
21 cellular response to lipopolysaccharide GO:0071222 9.8 CD86 CXCL10 IL10 IL6 TLR4 TNF
22 positive regulation of interleukin-12 production GO:0032735 9.79 IFNG TLR2 TLR4
23 negative regulation of myoblast differentiation GO:0045662 9.78 CXCL10 IL18 TNF
24 positive regulation of B cell proliferation GO:0030890 9.78 IL2 IL4 IL5 TLR4
25 regulation of regulatory T cell differentiation GO:0045589 9.77 CTLA4 IFNG IL2
26 natural killer cell activation GO:0030101 9.74 IL18 IL2
27 positive regulation of osteoclast differentiation GO:0045672 9.74 IFNG TNF
28 positive regulation of T cell differentiation GO:0045582 9.74 IL2 IL4
29 negative regulation of B cell proliferation GO:0030889 9.74 CTLA4 IL10
30 positive regulation of immunoglobulin secretion GO:0051024 9.74 IL2 IL5 IL6
31 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.73 IFNG TNF
32 positive regulation of macrophage activation GO:0043032 9.73 IL10 TLR4
33 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.73 TLR2 TLR4
34 negative regulation of growth of symbiont in host GO:0044130 9.73 IL10 TNF
35 response to molecule of bacterial origin GO:0002237 9.73 IL10 TLR2
36 lipopolysaccharide-mediated signaling pathway GO:0031663 9.73 IL18 TLR2 TLR4 TNF
37 positive regulation of interleukin-17 production GO:0032740 9.72 IL18 IL2
38 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.72 IL10 TNF
39 interferon-gamma production GO:0032609 9.72 IL18 TLR4
40 I-kappaB phosphorylation GO:0007252 9.72 TLR2 TLR4
41 positive regulation of podosome assembly GO:0071803 9.71 IL5 TNF
42 regulation of cytokine secretion GO:0050707 9.71 TLR2 TLR4
43 cellular response to lipoteichoic acid GO:0071223 9.71 TLR2 TLR4
44 negative regulation of interleukin-17 production GO:0032700 9.71 IFNG TLR4
45 T-helper 1 type immune response GO:0042088 9.71 IL18 TLR4
46 negative regulation of lipid storage GO:0010888 9.7 IL6 TNF
47 positive regulation of isotype switching to IgG isotypes GO:0048304 9.7 IL2 IL4
48 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.69 TLR4 TNF
49 endothelial cell apoptotic process GO:0072577 9.69 IL10 TNF
50 positive regulation of T-helper 2 cell differentiation GO:0045630 9.68 CD86 IL18

Molecular functions related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.35 IL10 IL2 IL4 IL5 IL6
2 cytokine activity GO:0005125 9.28 CXCL10 IFNG IL10 IL18 IL2 IL4
3 lipopolysaccharide receptor activity GO:0001875 9.16 TLR2 TLR4
4 protein binding GO:0005515 10.07 CD86 CTLA4 CXCL10 IFNG IL10 IL18

Sources for Paracoccidioidomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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