PCM
MCID: PRC002
MIFTS: 54

Paracoccidioidomycosis (PCM)

Categories: Bone diseases, Infectious diseases, Rare diseases, Respiratory diseases, Skin diseases
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Aliases & Classifications for Paracoccidioidomycosis

MalaCards integrated aliases for Paracoccidioidomycosis:

Name: Paracoccidioidomycosis 11 19 58 75 53 43 14 16 71 31 33
Mucocutaneous-Lymphangitic Paracoccidioidomycosis 11
Paracoccidioides Brasiliensis Infection 33
South American Blastomyces Infection 33
Paracoccidioidomycosis Unspecified 33
Lutz-Splendore-Almeida Disease 19
South American Blastomycosis 19
Paracoccidioidal Granuloma 19
Paracoccidioidal Mycosis 11
Brazilian Blastomycosis 33
Brazilian Blastomycotic 33
Lobo Disease 19
Lutz Disease 33
Lobomycosis 71
Pcm 19

Characteristics:


Age Of Onset:

All ages 58

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 11 DOID:12662
ICD9CM 34 116.1
MeSH 43 D010229
NCIt 49 C34891
SNOMED-CT 68 59925007
ICD10 31 B41 B41.9
MESH via Orphanet 44 D010229
ICD10 via Orphanet 32 B41.0 B41.7 B41.8 more
UMLS via Orphanet 72 C0030409
Orphanet 58 ORPHA73260
UMLS 71 C0030409 C0152066

Summaries for Paracoccidioidomycosis

GARD: 19 A rare mycosis characterized by an acute form mostly occurring in children and young adults presenting with fever, weight loss, lymph node enlargement, hepatosplenomegaly, and bone marrow dysfunction, versus a chronic form which usually involves the lungs and mucosae of the upper respiratory tract, skin, lymph nodes, and adrenal glands, but may affect any part of the body. The most common sequelae are chronic respiratory insufficiency and Addison's disease. The infectious agent, Paracoccidioides brasiliensis, is a fungus limited to Latin America.

MalaCards based summary: Paracoccidioidomycosis, also known as mucocutaneous-lymphangitic paracoccidioidomycosis, is related to histoplasmosis and cryptococcosis. An important gene associated with Paracoccidioidomycosis is IL10 (Interleukin 10), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include mucosa, lymph nodes and bone, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and homeostasis/metabolism

Orphanet: 58 A rare mycosis characterized by an acute form mostly occurring in children and young adults presenting with fever, weight loss, lymph node enlargement, hepatosplenomegaly, and bone marrow dysfunction, versus a chronic form which usually involves the lungs and mucosae of the upper respiratory tract, skin, lymph nodes, and adrenal glands, but may affect any part of the body. The most common sequelae are chronic respiratory insufficiency and Addison's disease. The infectious agent, Paracoccidioides brasiliensis, is a fungus limited to Latin America.

Disease Ontology: 11 A primary systemic mycosis that results in systemic fungal infection located in mucosa, located in lymph nodes, located in bone, located in skin or located in lungs, has material basis in Paracoccidioides brasiliensis.

Wikipedia: 75 Paracoccidioidomycosis (PCM), also known as South American blastomycosis, is a fungal infection that can... more...

Related Diseases for Paracoccidioidomycosis

Diseases related to Paracoccidioidomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 928)
# Related Disease Score Top Affiliating Genes
1 histoplasmosis 31.0 TNF IL12RB1 IFNG
2 cryptococcosis 30.7 TNF IL4 IL10 IFNG
3 sporotrichosis 30.7 TNF IL10 IFNG
4 actinomycosis 30.3 TNF IL10 ALB
5 human immunodeficiency virus type 1 30.1 IL2 IL10 IFNG CXCL10 CD209
6 hypereosinophilic syndrome 30.1 IL5 IL4 IL2 IL10 IFNG CXCL8
7 histiocytosis 30.1 TNF IL4 IFNG
8 extrinsic allergic alveolitis 30.1 TNF IL18 CXCL8 CD28
9 choroiditis 30.0 TNF IL10 IFNG
10 radiculopathy 30.0 IL6 IL5 IL10 CXCL9 CXCL8
11 macs syndrome 30.0 TNF IL12RB1 IL10 IFNG
12 anthracosis 30.0 TNF IL6 CXCL8
13 chronic beryllium disease 29.9 IL18 IFNG
14 acquired immunodeficiency syndrome 29.9 TNF IL6 IL2 IL10 IFNG ALB
15 haemophilus influenzae 29.9 TNF TLR2 CXCL8
16 alcohol use disorder 29.9 TNF TLR4 IL6 ALB
17 strongyloidiasis 29.9 IL5 IL4 IL10 IFNG
18 pneumoconiosis 29.8 TNF IL6 IL10 CXCL8
19 mucormycosis 29.8 TNF IL6 IL10 IFNG
20 lymph node tuberculosis 29.8 TNF IFNG ALB
21 hypopyon 29.8 TNF IL6 IL10
22 fatty liver disease 29.8 TNF TLR4 IL6 IL10
23 aortitis 29.8 TNF IL6 IFNG
24 adult respiratory distress syndrome 29.8 TNF IL6 IL10 CXCL8
25 inflammatory bowel disease 1 29.7 TNF TLR4 TLR2 IL6 IL10
26 intracranial hypertension 29.7 TNF IL6 ALB
27 penicilliosis 29.7 IL12RB1 IFNG
28 myelitis 29.7 TNF IL6 IL10 CXCL8
29 progressive multifocal leukoencephalopathy 29.7 TNF IL2 CTLA4
30 mucocutaneous leishmaniasis 29.6 TNF IL5 IL4 IL2 IL10
31 syphilis 29.6 TNF TLR2 CD209 ALB
32 silicosis 29.6 TNF TLR4 IL4 IL18 IL10 CXCL8
33 myositis 29.6 TNF IL6 IFNG CXCL10
34 hydrocephalus 29.6 TNF TLR4 IL10 IFNG
35 varicose veins 29.6 TNF IL6 CXCL8
36 neuromyelitis optica 29.5 IL6 IL5 IL4 CXCL10
37 retinal detachment 29.5 TNF IL6 IL10 IFNG CXCL8 CXCL10
38 serum amyloid a amyloidosis 29.5 TNF IL6 ALB
39 pulmonary emphysema 29.5 IL18 IFNG CXCL8 ALB
40 headache 29.5 TNF IL2 CXCL8 ALB
41 vasculitis 29.5 TNF IL6 IL10 CXCL8 CTLA4
42 bacterial meningitis 29.5 TNF TLR4 TLR2 IL10 CXCL8
43 intermittent claudication 29.5 IL6 IL10 ALB
44 meningoencephalitis 29.5 TNF IL6 IL10 CXCL10 ALB
45 interstitial lung disease 29.5 TNF IL6 IL4 IL18 IL10 IFNG
46 intestinal obstruction 29.5 TNF IL6 ALB
47 urinary tract obstruction 29.5 TNF IL6 ALB
48 erysipelas 29.4 TNF IL6 IL2
49 bowel dysfunction 29.4 TNF IL6 IL10 ALB
50 substance abuse 29.4 TNF TLR4 IL6 ALB

Graphical network of the top 20 diseases related to Paracoccidioidomycosis:



Diseases related to Paracoccidioidomycosis

Symptoms & Phenotypes for Paracoccidioidomycosis

GenomeRNAi Phenotypes related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.15 ALB CD209 CD28 CD86 CTLA4 CXCL10
2 no effect GR00402-S-2 10.15 ALB CD209 CD28 CD86 CTLA4 CXCL10
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 CD28 CXCL8 IL10 IL18 MYD88 TNF
4 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 CD28 CXCL8 IL10 IL18 IL2 MYD88

MGI Mouse Phenotypes related to Paracoccidioidomycosis:

45 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.47 ALB CD209 CD28 CD86 CTLA4 CXCL10
2 immune system MP:0005387 10.35 ALB CD209 CD28 CD86 CTLA4 CXCL10
3 nervous system MP:0003631 10.33 CD28 CD86 CXCL10 IFNG IL10 IL18
4 digestive/alimentary MP:0005381 10.33 ALB CD209 CD28 CTLA4 IFNG IL10
5 cellular MP:0005384 10.31 ALB CD209 CD28 CD86 CXCL10 IFNG
6 neoplasm MP:0002006 10.3 ALB CD28 IFNG IL10 IL2 IL5
7 liver/biliary system MP:0005370 10.3 ALB CTLA4 IFNG IL10 IL2 IL4
8 endocrine/exocrine gland MP:0005379 10.26 ALB CD28 CD86 CTLA4 IFNG IL10
9 muscle MP:0005369 10.19 ALB CD86 IFNG IL10 IL18 IL6
10 cardiovascular system MP:0005385 10.18 ALB CTLA4 CXCL10 IFNG IL10 IL18
11 adipose tissue MP:0005375 10.11 CD209 IL12RB1 IL18 IL6 MYD88 TLR2
12 hematopoietic system MP:0005397 10.11 CD209 CD28 CD86 CTLA4 CXCL10 CXCL9
13 respiratory system MP:0005388 10.06 CTLA4 IFNG IL10 IL2 IL4 IL5
14 vision/eye MP:0005391 10 CD28 IFNG IL10 IL12RB1 IL18 IL2
15 mortality/aging MP:0010768 9.83 ALB CD209 CTLA4 CXCL10 CXCL9 IFNG
16 integument MP:0010771 9.4 CD28 CTLA4 IFNG IL10 IL12RB1 IL18

Drugs & Therapeutics for Paracoccidioidomycosis

Search Clinical Trials, NIH Clinical Center for Paracoccidioidomycosis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Itraconazole
Ketoconazole

Cochrane evidence based reviews: paracoccidioidomycosis

Genetic Tests for Paracoccidioidomycosis

Anatomical Context for Paracoccidioidomycosis

Organs/tissues related to Paracoccidioidomycosis:

FMA: Mucosa, Lymph Nodes, Bone, Skin, Lungs
MalaCards : Lymph Node, Bone Marrow, Skin, Bone, Spleen, Liver, T Cells

Publications for Paracoccidioidomycosis

Articles related to Paracoccidioidomycosis:

(show top 50) (show all 2204)
# Title Authors PMID Year
1
Role of TLR2 and TLR4 in human neutrophil functions against Paracoccidioides brasiliensis. 53 62
20384861 2010
2
Altered expression of the costimulatory molecules CD80, CD86, CD152, PD-1 and ICOS on T-cells from paracoccidioidomycosis patients: lack of correlation with T-cell hyporesponsiveness. 53 62
18757242 2008
3
Serum interleukin-18 and soluble tumour necrosis factor receptor 2 are associated with disease severity in patients with paracoccidioidomycosis. 53 62
17302897 2007
4
Kinetics of IFN-gamma, TNF-alpha, IL-10 and IL-4 production by mononuclear cells stimulated with gp43 peptides, in patients cured of paracoccidioidomycosis. 53 62
17568881 2007
5
Interleukin-10 and tumor necrosis factor-alpha single nucleotide gene polymorphism frequency in paracoccidioidomycosis. 53 62
17145373 2006
6
Cytokines released from blood monocytes and expressed in mucocutaneous lesions of patients with paracoccidioidomycosis evaluated before and during trimethoprim-sulfamethoxazole treatment. 53 62
16536806 2006
7
The role of interleukin-10 in the differential expression of interleukin-12p70 and its beta2 receptor on patients with active or treated paracoccidioidomycosis and healthy infected subjects. 53 62
15596413 2005
8
Modulation of CD28 and CD86 expression in patients with paracoccidioidomycosis in different periods of treatment. 53 62
15541043 2004
9
Proteomic identification, nucleotide sequence, heterologous expression and immunological reactivity of the triosephosphate isomerase of Paracoccidioides brasiliensis. 53 62
15310465 2004
10
Fas-Fas ligand (CD95-CD95L) and cytotoxic T lymphocyte antigen-4 engagement mediate T cell unresponsiveness in patients with paracoccidioidomycosis. 53 62
12717632 2003
11
Dendritic cells and pattern of cytokines in paracoccidioidomycosis skin lesions. 53 62
12652191 2003
12
Heterologous expression, purification, and immunological reactivity of a recombinant HSP60 from Paracoccidioides brasiliensis. 53 62
11874881 2002
13
Molecular cloning, characterization and expression of the heat shock protein 60 gene from the human pathogenic fungus Paracoccidioides brasiliensis. 53 62
12054056 2001
14
High serum interleukin-10 and tumor necrosis factor alpha levels in chronic paracoccidioidomycosis. 53 62
11527826 2001
15
Imbalance of IL-2, IFN-gamma and IL-10 secretion in the immunosuppression associated with human paracoccidioidomycosis. 53 62
11237434 2001
16
The Impact of Paracoccidioides spp Infection on Central Nervous System Cell Junctional Complexes. 62
35922705 2022
17
Virtual screening and repurposing of approved drugs targeting homoserine dehydrogenase from Paracoccidioides brasiliensis. 62
36323986 2022
18
Using infrared spectroscopy of serum and chemometrics for diagnosis of paracoccidioidomycosis. 62
36113324 2022
19
A lateral flow assay for the immunodiagnosis of human cat-transmitted sporotrichosis. 62
35943444 2022
20
Severe paracoccidioidomycosis, with a fatal outcome and incidence related to an environmental event. 62
36253243 2022
21
Kidney impairment in a child with acute-subacute paracoccidioidomycosis: Answers. 62
36214887 2022
22
Kidney impairment in a child with acute-subacute paracoccidioidomycosis: Questions. 62
36214885 2022
23
Paracoccidioidomycosis: What We Know and What Is New in Epidemiology, Diagnosis, and Treatment. 62
36294662 2022
24
[Oral paracoccidiodomycosis in an immunocompetent woman: a case report and literature review]. 62
36154729 2022
25
Systematic review of neuroparacoccidioidomycosis: The contribution of neuroimaging. 62
36062632 2022
26
Combined Silymarin and Cotrimoxazole Therapy Attenuates Pulmonary Fibrosis in Experimental Paracoccidioidomycosis. 62
36294575 2022
27
Paracoccidioidomycosis screening diagnosis by FTIR spectroscopy and multivariate analysis. 62
35598713 2022
28
Paracoccidioidomycosis: Current Status and Future Trends. 62
36074014 2022
29
Immunologic Diagnosis of Endemic Mycoses. 62
36294558 2022
30
Head and neck manifestations of paracoccidioidomycosis: A retrospective study of histopathologically diagnosed cases in two medical centers in southern Brazil. 62
35580434 2022
31
Proteomic alterations in Paracoccidioides brasiliensis caused by exposure to curcumin. 62
35835316 2022
32
Performance of Two Commercial Assays for the Detection of Serum Aspergillus Galactomannan in Non-Neutropenic Patients. 62
35887496 2022
33
Paracoccidioidomycosis in people living with HIV/AIDS: A historical retrospective cohort study in a national reference center for infectious diseases, Rio de Janeiro, Brazil. 62
35704666 2022
34
Phototherapies as an adjuvant treatment for oral paracoccidioidomycosis. 62
35183781 2022
35
PbGP43 Genotyping Using Paraffin-Embedded Biopsies of Human Paracoccidioidomycosis Reveals a Genetically Distinct Lineage in the Paracoccidioides brasiliensis Complex. 62
34870754 2022
36
Clinical and Eco-Epidemiological Aspects of a Novel Hyperendemic Area of Paracoccidioidomycosis in the Tocantins-Araguaia Basin (Northern Brazil), Caused by Paracoccidioides sp. 62
35628757 2022
37
The Multifaceted Role of Mating Type of the Fungus and Sex of the Host in Studies of Fungal Infections in Humans. 62
35628717 2022
38
Compulsory notification of paracoccidioidomycosis: A 14-year retrospective study of the disease in the state of Paraná, Brazil. 62
34936142 2022
39
Lobomycosis and paracoccidioidomycosis meet again. 62
35283022 2022
40
Mixed infection by Cryptococcus neoformans and Cryptococcus gattii and coinfection with paracoccidioidomycosis in PLHIV. 62
35256962 2022
41
Paracoccidioidomycosis Simulating Eyelid Carcinoma. 62
35429963 2022
42
Photodynamic therapy in the treatment of oral lesions caused by paracoccidiomycosis. 62
34823032 2022
43
Biochemical characterization and analysis of gene expression of an α-mannosidase secreted by Paracoccidioides brasiliensis. 62
35076076 2022
44
Intestinal Paracoccidioidomycosis: Case report and literature review. 62
35121286 2022
45
Pulmonary and cerebral paracoccidioidomycosis. 62
36134863 2022
46
Disseminated paracoccidioidomycosis associated with lymph node tuberculosis in a non immunocompromised child. 62
35663608 2022
47
A scoping study of pulmonary paracoccidioidomycosis: severity classification based on radiographic and tomographic evaluation. 62
36465893 2022
48
Chronic exposure to cigarette smoke transiently worsens the disease course in a mouse model of pulmonary paracoccidioidomycosis. 62
36383893 2022
49
Disseminated paracoccidioidomycosis with skull and mandible involvement in a heart transplant recipient. 62
35674557 2022
50
Paracoccidioidomycosis with sarcoid-like cutaneous lesion: A clinicopathological challenge. 62
35923859 2022

Variations for Paracoccidioidomycosis

Expression for Paracoccidioidomycosis

Search GEO for disease gene expression data for Paracoccidioidomycosis.

Pathways for Paracoccidioidomycosis

Pathways related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.07 TNF TLR4 TLR2 MYD88 IL6 IL5
2
Show member pathways
13.96 TNF IL6 IL5 IL4 IL2 IL18
3 13.87 TNF MYD88 IL6 IL5 IL2 CXCL9
4
Show member pathways
13.79 TNF TLR4 IL6 IL5 IL4 IL2
5
Show member pathways
13.67 TNF IL6 IL5 IL4 IL2 IL18
6
Show member pathways
13.55 IFNG IL2 IL4 IL6 MYD88 TLR2
7
Show member pathways
13.5 CD86 CXCL10 CXCL8 IFNG IL10 IL12RB1
8
Show member pathways
13.5 TNF TLR4 TLR2 MYD88 IL6 IL5
9
Show member pathways
13.48 CD28 CXCL10 CXCL8 CXCL9 IL10 IL12RB1
10
Show member pathways
12.96 CD209 CD28 CD86 CXCL10 CXCL8 CXCL9
11
Show member pathways
12.84 TNF TLR4 TLR2 MYD88 IL6 IL2
12
Show member pathways
12.84 TNF IL6 IL5 IL4 IL2 IL18
13
Show member pathways
12.8 TNF TLR2 MYD88 IL6 IL18 CXCL8
14
Show member pathways
12.79 TNF IL6 IL2 IL18 IL12RB1 IL10
15 12.76 CD28 CTLA4 CXCL10 IFNG IL10 IL2
16
Show member pathways
12.72 TNF TLR4 TLR2 MYD88 IL6 IL18
17
Show member pathways
12.65 TNF TLR4 TLR2 MYD88 IL6 IL4
18
Show member pathways
12.5 TLR4 IFNG CXCL8 CXCL10
19
Show member pathways
12.5 CXCL8 IFNG IL6 MYD88 TLR4 TNF
20
Show member pathways
12.47 MYD88 IL6 IL18 CXCL10
21
Show member pathways
12.42 TNF TLR2 IL6 CXCL8 CXCL10
22 12.35 TNF TLR4 TLR2 IL6 IFNG
23
Show member pathways
12.34 IL2 CTLA4 CD86 CD28
24
Show member pathways
12.28 TNF IL4 IL2 IFNG
25
Show member pathways
12.28 IL2 IL12RB1 CD86 CD28
26 12.27 TNF IL6 IL4 IL10 IFNG
27 12.26 TNF IL6 IL10 CXCL8
28 12.23 TNF TLR4 IL6 IL4 IL2 IFNG
29 12.18 TNF IL6 IL4 IL18 IL10 CXCL8
30
Show member pathways
12.16 IL4 IL2 IL18 IL12RB1 IFNG
31
Show member pathways
12.13 IL2 IL5 TLR2 TLR4
32
Show member pathways
12.08 CXCL8 IL12RB1 IL6 MYD88 TLR4
33
Show member pathways
12.08 CD28 CD86 CTLA4 IFNG IL10 IL12RB1
34
Show member pathways
12.07 TLR4 TLR2 IL6 IL4 IL12RB1 IFNG
35
Show member pathways
12.06 TNF TLR4 TLR2 IL6 IL2 IL18
36 12.02 IL6 IL5 IL4 IL2 IFNG CXCL8
37 12 TLR4 IL2 IL18 CXCL8
38 12 TNF IL6 IL2 IL10 IFNG CD209
39 12 TNF TLR4 IL6 IL4 IL2 IL10
40 12 IFNG IL10 IL12RB1 IL18 IL2 IL4
41 11.97 TNF TLR4 MYD88 IL6 CXCL8
42 11.97 TLR4 IL6 IL2 IL10 IFNG
43 11.97 IL6 IL5 IL4 IL2 IL10 IFNG
44 11.97 TNF IL5 IL4 IL2 IL10 IFNG
45
Show member pathways
11.95 CTLA4 CXCL8 IFNG IL2 IL4 IL5
46 11.92 TNF TLR4 MYD88 IL6 IL10 CXCL8
47 11.89 CXCL8 IL4 IL5 IL6 TNF
48
Show member pathways
11.89 CXCL8 IFNG IL2 IL6 TNF
49 11.88 TNF TLR4 MYD88 IL6 IL10
50
Show member pathways
11.88 TLR2 IL6 IL5 IL4 IL2 IL18

GO Terms for Paracoccidioidomycosis

Cellular components related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.27 ALB CD209 CXCL10 CXCL8 CXCL9 IFNG
2 extracellular space GO:0005615 10.03 ALB CXCL10 CXCL8 CXCL9 IFNG IL10
3 external side of plasma membrane GO:0009897 9.58 TNF TLR4 IL12RB1 CXCL9 CXCL10 CTLA4
4 protein complex involved in cell adhesion GO:0098636 9.56 CTLA4 CD28

Biological processes related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.67 TNF TLR4 TLR2 IL6 IL4 IL2
2 positive regulation of cell population proliferation GO:0008284 10.5 IL6 IL5 IL4 IL2 IFNG CXCL10
3 negative regulation of apoptotic process GO:0043066 10.5 ALB CD28 IL10 IL2 IL4 IL6
4 signal transduction GO:0007165 10.5 CXCL10 CXCL8 CXCL9 IFNG IL10 IL12RB1
5 defense response to virus GO:0051607 10.4 CXCL10 CXCL9 IFNG IL6 MYD88 TLR2
6 positive regulation of gene expression GO:0010628 10.38 CD28 CXCL8 IFNG IL18 IL4 IL6
7 defense response to Gram-positive bacterium GO:0050830 10.36 TNF TLR2 MYD88 IL6 IL18
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.36 IL18 IL6 MYD88 TLR2 TLR4 TNF
9 positive regulation of tumor necrosis factor production GO:0032760 10.34 IFNG IL6 MYD88 TLR2 TLR4
10 positive regulation of DNA-binding transcription factor activity GO:0051091 10.33 TNF IL6 IL5 IL10
11 positive regulation of inflammatory response GO:0050729 10.33 TNF TLR4 TLR2 IL2 IL18 IFNG
12 positive regulation of type II interferon production GO:0032729 10.32 IL12RB1 IL18 IL2 TLR4 TNF
13 cellular response to type II interferon GO:0071346 10.31 TNF TLR4 TLR2 IL12RB1
14 positive regulation of interleukin-6 production GO:0032755 10.3 IFNG IL6 MYD88 TLR2 TLR4 TNF
15 inflammatory response GO:0006954 10.3 CXCL10 CXCL8 CXCL9 IL18 IL5 IL6
16 positive regulation of cytokine production GO:0001819 10.28 TNF IL10 IFNG CD28
17 positive regulation of NIK/NF-kappaB signaling GO:1901224 10.28 CD86 IL18 TLR2 TLR4 TNF
18 humoral immune response GO:0006959 10.27 TNF IL6 IFNG CD28
19 positive regulation of interleukin-8 production GO:0032757 10.27 TNF TLR4 TLR2 MYD88 IL6
20 positive regulation of interleukin-1 beta production GO:0032731 10.27 TNF TLR4 MYD88 IL6 IFNG
21 positive regulation of B cell proliferation GO:0030890 10.26 TLR4 IL5 IL4 IL2
22 positive regulation of smooth muscle cell proliferation GO:0048661 10.26 IL18 IL6 MYD88 TLR4 TNF
23 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.23 TNF IL6 IL5 IL10
24 immune system process GO:0002376 10.22 TLR4 TLR2 MYD88 IL2 CTLA4 CD86
25 negative regulation of T cell proliferation GO:0042130 10.21 IL10 CTLA4 CD86
26 positive regulation of interleukin-12 production GO:0032735 10.21 TLR4 TLR2 IFNG
27 microglial cell activation GO:0001774 10.21 IFNG IL4 TLR2 TNF
28 positive regulation of cytokine production involved in inflammatory response GO:1900017 10.21 IL6 MYD88 TLR4 TNF
29 positive regulation of interleukin-10 production GO:0032733 10.21 TLR4 TLR2 IL6 IL4 CD28
30 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 10.21 IFNG IL18 IL2 IL4 IL6 TNF
31 positive regulation of nitric oxide biosynthetic process GO:0045429 10.2 TNF TLR4 IFNG
32 response to virus GO:0009615 10.2 TNF MYD88 IFNG CXCL10
33 positive regulation of interleukin-17 production GO:0032740 10.2 MYD88 IL6 IL2 IL18
34 liver regeneration GO:0097421 10.19 TNF IL6 IL10
35 lipopolysaccharide-mediated signaling pathway GO:0031663 10.19 TNF TLR4 TLR2 MYD88 IL18
36 positive regulation of activated T cell proliferation GO:0042104 10.18 IL2 IL18 IL12RB1
37 negative regulation of myoblast differentiation GO:0045662 10.18 TNF IL18 CXCL10
38 MyD88-dependent toll-like receptor signaling pathway GO:0002755 10.16 TLR4 TLR2 MYD88
39 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 10.16 TLR4 TLR2 IFNG
40 positive regulation of immunoglobulin production GO:0002639 10.16 IL6 IL5 IL2 IL10 CD86
41 response to lipopolysaccharide GO:0032496 10.14 TNF TLR4 TLR2 MYD88 IL10 CXCL10
42 positive regulation of MHC class II biosynthetic process GO:0045348 10.14 TLR4 IL4 IL10 IFNG
43 defense response GO:0006952 10.12 TNF CXCL9 CXCL8 CXCL10
44 positive regulation of neuroinflammatory response GO:0150078 10.12 TNF IL6 IL18
45 positive regulation of isotype switching to IgG isotypes GO:0048304 10.12 IL4 IL2 CD28
46 positive regulation of T cell proliferation GO:0042102 10.11 IL6 IL4 IL2 CD86 CD28 CD209
47 type 2 immune response GO:0042092 10.1 IL4 IL18 IL10
48 cellular response to lipopolysaccharide GO:0071222 10.09 TNF TLR4 MYD88 IL6 IL10 CXCL9
49 response to molecule of bacterial origin GO:0002237 10.05 TLR2 IL10 CXCL8
50 positive regulation of oxidative stress-induced neuron death GO:1903223 10.04 TNF TLR4

Molecular functions related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.85 IL6 IL5 IL4 IL2 IL10
2 Toll-like receptor binding GO:0035325 9.67 TLR2 MYD88
3 CXCR3 chemokine receptor binding GO:0048248 9.62 CXCL9 CXCL10
4 cytokine activity GO:0005125 9.62 TNF IL6 IL5 IL4 IL2 IL18
5 lipopolysaccharide immune receptor activity GO:0001875 9.56 TLR4 TLR2
6 CXCR chemokine receptor binding GO:0045236 9.43 CXCL10 CXCL8 CXCL9

Sources for Paracoccidioidomycosis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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