PCM
MCID: PRC002
MIFTS: 61

Paracoccidioidomycosis (PCM)

Categories: Bone diseases, Immune diseases, Infectious diseases, Rare diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Paracoccidioidomycosis

MalaCards integrated aliases for Paracoccidioidomycosis:

Name: Paracoccidioidomycosis 12 76 53 59 55 44 15 73
Mucocutaneous-Lymphangitic Paracoccidioidomycosis 12
Lutz-Splendore-Almeida Disease 53
South American Blastomycosis 53
Paracoccidioidal Granuloma 53
Paracoccidioidal Mycosis 12
Lobo Disease 53
Lobomycosis 73
Pcm 53

Characteristics:

Orphanet epidemiological data:

59
paracoccidioidomycosis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:12662
ICD10 33 B41 B41.9
ICD9CM 35 116.1
MeSH 44 D010229
NCIt 50 C34891
SNOMED-CT 68 36866003 59925007
Orphanet 59 ORPHA73260
ICD10 via Orphanet 34 B41.8 B41.9 B41.0 more
MESH via Orphanet 45 D010229
UMLS via Orphanet 74 C0030409

Summaries for Paracoccidioidomycosis

Disease Ontology : 12 A primary systemic mycosis that results in systemic fungal infection located in mucosa, located in lymph nodes, located in bone, located in skin or located in lungs, has material basis in Paracoccidioides brasiliensis.

MalaCards based summary : Paracoccidioidomycosis, also known as mucocutaneous-lymphangitic paracoccidioidomycosis, is related to mucocutaneous leishmaniasis and coccidioidomycosis. An important gene associated with Paracoccidioidomycosis is IL10 (Interleukin 10), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include skin, lung and bone, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 Paracoccidioidomycosis (PCM) (also known as "Brazilian blastomycosis", "South American blastomycosis",... more...

Related Diseases for Paracoccidioidomycosis

Diseases related to Paracoccidioidomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 400)
# Related Disease Score Top Affiliating Genes
1 mucocutaneous leishmaniasis 30.1 IL10 TNF
2 coccidioidomycosis 30.0 IL10 TLR4
3 sarcoidosis 1 29.9 IFNG IL2 TNF
4 acquired immunodeficiency syndrome 29.8 IFNG IL10 IL2 IL6 TNF
5 osteomyelitis 29.8 IFNG IL10 IL6 TNF
6 pulmonary tuberculosis 29.7 IFNG IL10 IL2 IL4 TLR2 TNF
7 arthritis 29.6 IFNG IL10 IL6 TNF
8 human immunodeficiency virus infectious disease 29.5 IFNG IL10 IL2 IL6 TNF
9 penicilliosis 29.5 CD86 TLR2 TLR4 TNF
10 lung disease 29.3 CXCL10 IL10 IL5 IL6 TLR2 TNF
11 viral infectious disease 29.3 CXCL10 IFNG IL10 IL2 IL4 IL6
12 schistosomiasis 29.3 IFNG IL10 IL2 IL4 IL5 TNF
13 pneumonia 29.0 IL10 IL5 IL6 TLR2 TLR4 TNF
14 aspergillosis 29.0 IFNG IL10 IL4 IL5 TLR2 TLR4
15 leishmaniasis 28.4 IFNG IL10 IL2 IL4 IL5 IL6
16 multiple sclerosis 28.4 CD86 CTLA4 CXCL10 IFNG IL10 IL2
17 rheumatoid arthritis 28.2 CD86 CTLA4 IFNG IL10 IL2 IL4
18 systemic lupus erythematosus 28.0 CD86 CTLA4 CXCL10 IFNG IL10 IL2
19 blastomycosis 10.5
20 choroiditis 10.3 IL10 TNF
21 trichuriasis 10.3 IL10 TNF
22 transient hypogammaglobulinemia 10.3 IL10 TNF
23 sporotrichosis 10.3 IFNG IL10
24 trichosporonosis 10.3 IFNG TNF
25 microscopic polyangiitis 10.3 IL10 TNF
26 multifocal choroiditis 10.3 IL10 TNF
27 idiopathic achalasia 10.3 IL10 TNF
28 punctate inner choroidopathy 10.3 IL10 TNF
29 pericardial tuberculosis 10.3 IFNG IL10
30 miliary tuberculosis 10.3 IFNG TNF
31 staphylococcal toxic shock syndrome 10.3 IFNG TNF
32 chronic beryllium disease 10.3 IFNG TNF
33 retinitis pigmentosa 22 10.3 IL10 IL4
34 histoplasmosis 10.3
35 beta-lactam allergy 10.3 IL10 IL4
36 asymptomatic neurosyphilis 10.3 CXCL10 IFNG
37 opisthorchiasis 10.3 IL4 TNF
38 crustacean allergy 10.3 IFNG IL4
39 necatoriasis 10.3 IL10 IL5
40 eosinophilic fasciitis 10.3 IFNG IL5
41 strongyloidiasis 10.3 IFNG IL5
42 eosinophilia-myalgia syndrome 10.3 IFNG IL5
43 type 1 diabetes mellitus 13 10.3 CD86 CTLA4
44 inflammatory bowel disease 4 10.3 IL4 IL5
45 cough variant asthma 10.3 IL4 IL5
46 egg allergy 10.2 IL4 IL5
47 intrinsic asthma 10.2 IL4 IL5
48 trichinosis 10.2 IL4 IL5
49 congenital cytomegalovirus 10.2 TLR2 TNF
50 haemophilus influenzae 10.2 TLR2 TNF

Graphical network of the top 20 diseases related to Paracoccidioidomycosis:



Diseases related to Paracoccidioidomycosis

Symptoms & Phenotypes for Paracoccidioidomycosis

MGI Mouse Phenotypes related to Paracoccidioidomycosis:

46 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.36 CD86 CTLA4 CXCL10 IFNG IL10 IL2
2 homeostasis/metabolism MP:0005376 10.35 CD86 CTLA4 CXCL10 IFNG IL10 IL2
3 immune system MP:0005387 10.34 CD86 CTLA4 CXCL10 IFNG IL10 IL2
4 cellular MP:0005384 10.32 CD86 CXCL10 IFNG IL10 IL2 IL4
5 digestive/alimentary MP:0005381 10.32 CTLA4 IFNG IL10 IL2 IL4 IL5
6 behavior/neurological MP:0005386 10.3 CD86 IFNG IL10 IL2 IL5 IL6
7 cardiovascular system MP:0005385 10.29 CTLA4 CXCL10 IFNG IL10 IL2 IL6
8 endocrine/exocrine gland MP:0005379 10.27 CD86 CTLA4 IFNG IL10 IL2 IL4
9 growth/size/body region MP:0005378 10.26 IFNG IL10 IL2 IL4 IL5 IL6
10 mortality/aging MP:0010768 10.22 CTLA4 CXCL10 IFNG IL10 IL2 IL4
11 liver/biliary system MP:0005370 10.19 CTLA4 IFNG IL10 IL2 IL4 IL5
12 integument MP:0010771 10.11 CTLA4 IFNG IL10 IL4 IL6 TLR2
13 nervous system MP:0003631 10.1 CD86 CXCL10 IFNG IL10 IL4 IL6
14 neoplasm MP:0002006 10.09 IFNG IL10 IL2 IL5 IL6 MYD88
15 muscle MP:0005369 10 CD86 IFNG IL10 IL6 TLR2 TLR4
16 reproductive system MP:0005389 9.91 IFNG IL10 IL2 IL4 IL5 IL6
17 respiratory system MP:0005388 9.9 CTLA4 IFNG IL10 IL2 IL4 IL5
18 no phenotypic analysis MP:0003012 9.85 IFNG IL10 IL2 IL4 MYD88 TNF
19 renal/urinary system MP:0005367 9.8 IFNG IL4 IL6 MYD88 TLR2 TLR4
20 skeleton MP:0005390 9.61 CTLA4 IFNG IL10 IL4 IL6 MYD88
21 vision/eye MP:0005391 9.23 IFNG IL10 IL2 IL4 IL6 MYD88

Drugs & Therapeutics for Paracoccidioidomycosis

Search Clinical Trials , NIH Clinical Center for Paracoccidioidomycosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: paracoccidioidomycosis

Genetic Tests for Paracoccidioidomycosis

Anatomical Context for Paracoccidioidomycosis

MalaCards organs/tissues related to Paracoccidioidomycosis:

41
Skin, Lung, Bone, Lymph Node, Testes, T Cells, Prostate

The Foundational Model of Anatomy Ontology organs/tissues related to Paracoccidioidomycosis:

19
Skin Or, Bone, Mucosa, Lymph Nodes

Publications for Paracoccidioidomycosis

Articles related to Paracoccidioidomycosis:

(show top 50) (show all 888)
# Title Authors Year
1
Pulmonary paracoccidioidomycosis associated with the use of natalizumab in multiple sclerosis. ( 29649930 )
2018
2
Intestinal paracoccidioidomycosis resembling Crohn's disease in a teenager: a case report. ( 29706133 )
2018
3
Case Report: Misleading Serological Diagnosis of Paracoccidioidomycosis in a Young Patient with the Acute Form Disease:<i>Paracoccidioides brasiliensis</i>or<i>Paracoccidioides lutzii</i>? ( 29405111 )
2018
4
67Ga Scintigraphy for Assessment of Disease Severity and Treatment Response in Patients With Paracoccidioidomycosis. ( 29517539 )
2018
5
Paracoccidioidomycosis due to Paracoccidioides brasiliensis S1 plus HIV co-infection. ( 29412355 )
2018
6
Diagnosis and Treatment of Paracoccidioidomycosis in the Maxillofacial Region: A Report of 5 Cases. ( 29850333 )
2018
7
Paracoccidioidomycosis diagnosed in bone marrow biopsy: indicative of fungemia and unfavorable prognois. ( 29944929 )
2018
8
Paracoccidioidomycosis simulating Crohn's disease. ( 29746902 )
2018
9
Unusual Intestinal Involvement by Paracoccidioidomycosis Diagnosed After Oral Manifestation. ( 29453699 )
2018
10
Paracoccidioidomycosis: Detection of Paracoccidioides brasiliensisA' genome in biological samples by quantitative chain reaction polymerase (qPCR). ( 29803846 )
2018
11
Geographical evaluation of Neuroparacoccidioidomycosis and Paracoccidioidomycosis in Southern Brazil. ( 29663530 )
2018
12
Scrotal swelling in a farmworker with paracoccidioidomycosis. ( 29551333 )
2018
13
Emergence of acute/subacute infant-juvenile paracoccidioidomycosis in Northeast Argentina: Effect of climatic and anthropogenic changes? ( 29346653 )
2018
14
A case of paracoccidioidomycosis due to<i>Paracoccidioides lutzii</i>presenting sarcoid-like form. ( 29159027 )
2018
15
Imaging paracoccidioidomycosis: A pictorial review from head to toe. ( 29685479 )
2018
16
Sarcoid-Like Paracoccidioidomycosis in a Female Urban Dweller: Reviewing a Rare Clinical Condition in Brazil. ( 29737451 )
2018
17
Estrogen Receptor-I+ Correlates with Higher Fungal Cell Number in Oral Paracoccidioidomycosis in Women. ( 29796757 )
2018
18
A multicentre study of oral paracoccidioidomycosis: analysis of 320 cases and literature review. ( 29949225 )
2018
19
Disseminated paracoccidioidomycosis prediagnosticated as neoplasm: An important challenge in diagnosis using rt-PCR. ( 29071205 )
2018
20
Pulmonary paracoccidioidomycosis: a case report of reactivation in a patient receiving biological therapy. ( 29768566 )
2018
21
Potential of the association of dodecyl gallate with nanostructured lipid system as a treatment for paracoccidioidomycosis: In vitro and in vivo efficacy and toxicity. ( 29883792 )
2018
22
67Ga Scintigraphy for Assessment of Disease Severity and Treatment Response in Patients With Paracoccidioidomycosis: Erratum. ( 29688954 )
2018
23
Notch Signaling is Required for Dendritic Cell Maturation and T Cell Expansion in Paracoccidioidomycosis. ( 29911286 )
2018
24
Differentiation of mucosal lesions in mucocutaneous leishmaniasis and paracoccidioidomycosis. ( 30475920 )
2018
25
Acute paracoccidioidomycosis with duodenal and cutaneous involvement and obstructive jaundice. ( 30148057 )
2018
26
Combination of Histopathology and FT-Raman Spectroscopy for the Study of Experimental Paracoccidioidomycosis in the Spleen. ( 28881447 )
2018
27
Differential production of interleukin-1 family cytokines (IL-1β, IL-18, IL-33 and IL-37) in patients with paracoccidioidomycosis: correlation with clinical form and antifungal therapy. ( 28992214 )
2018
28
Chronic Multifocal Paracoccidioidomycosis: Pulmonary and Cutaneous Involvement. ( 29793811 )
2018
29
Systemic paracoccidioidomycosis involving breast. ( 30033640 )
2018
30
Regulatory T cells in paracoccidioidomycosis. ( 30067137 )
2018
31
Computer-aided identification of novel anti-paracoccidioidomycosis compounds. ( 30311802 )
2018
32
Ceruloplasmin, transferrin and apolipoprotein A-II play important role in treatment's follow-up of paracoccidioidomycosis patients. ( 30359420 )
2018
33
DC-SIGN and VDR polymorphisms are associated with chronic form of paracoccidioidomycosis with oral manifestations. ( 30367528 )
2018
34
Depletion of regulatory T cells in ongoing paracoccidioidomycosis rescues protective Th1/Th17 immunity and prevents fatal disease outcome. ( 30410119 )
2018
35
Paracoccidioidomycosis: characterization of subpopulations of macrophages and cytokines in human mucosal lesions. ( 30418569 )
2018
36
Paracoccidioidomycosis manifested by sarcoidosis-like cutaneous lesions and caused by Paracoccidioides brasiliensis sensu stricto (S1a). ( 30484542 )
2018
37
Itraconazole in combination with neutrophil depletion reduces the expression of genes related to pulmonary fibrosis in an experimental model of paracoccidioidomycosis. ( 29420794 )
2017
38
Th1-Inducing Agents in Prophylaxis and Therapy for Paracoccidioidomycosis. ( 28584990 )
2017
39
Acute Paracoccidioidomycosis in a 40-Year-Old Man: A Case Report and Literature Review. ( 28900882 )
2017
40
Paracoccidioidomycosis: level of pulmonary sequelae in high resolution computed tomography images from patients of two endemic regions of Brazil. ( 28811998 )
2017
41
Therapeutic treatment with scFv-PLGA nanoparticles decreases pulmonary fungal load in a murine model of paracoccidioidomycosis. ( 28951317 )
2017
42
Bone marrow-derived mesenchymal stem cells transplantation alters the course of experimental paracoccidioidomycosis by exacerbating the chronic pulmonary inflammatory response. ( 29253200 )
2017
43
Paracoccidioidomycosis with sarcoid-like lesions:a diagnostic challenge. ( 28562770 )
2017
44
DNAhsp65 Vaccine as Therapy against Paracoccidioidomycosis. ( 28584985 )
2017
45
Hypereosinophilia Secondary to Disseminated Paracoccidioidomycosis. ( 29042530 )
2017
46
Paracoccidioidomycosis: Epidemiological and Clinical Aspects in 546 Cases Studied in the State of EspA-rito Santo, Brazil. ( 28749757 )
2017
47
New Trends in Paracoccidioidomycosis Epidemiology. ( 29371520 )
2017
48
Paracoccidioidomycosis ceti in an Atlantic bottlenose dolphin (Tursiops truncatus), Brazil. ( 29205896 )
2017
49
Altered distribution of peripheral blood dendritic cell subsets in patients with pulmonary paracoccidioidomycosis. ( 28606816 )
2017
50
Impaired anti-fibrotic effect of bone marrow-derived mesenchymal stem cell in a mouse model of pulmonary paracoccidioidomycosis. ( 29040281 )
2017

Variations for Paracoccidioidomycosis

Expression for Paracoccidioidomycosis

Search GEO for disease gene expression data for Paracoccidioidomycosis.

Pathways for Paracoccidioidomycosis

Pathways related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.05 CD86 CTLA4 CXCL10 IFNG IL10 IL2
2
Show member pathways
13.71 CXCL10 IFNG IL10 IL2 IL4 IL5
3
Show member pathways
13.53 IFNG IL10 IL2 IL4 IL5 IL6
4
Show member pathways
13.5 CXCL10 IL10 IL2 IL4 IL5 IL6
5
Show member pathways
13.46 CD86 CXCL10 IFNG IL10 IL2 IL4
6
Show member pathways
13.34 CXCL10 IL10 IL2 IL4 IL5 IL6
7
Show member pathways
13.26 IFNG IL2 IL4 MYD88 TLR2 TLR4
8
Show member pathways
13.1 CD86 IL6 MYD88 TLR2 TLR4 TNF
9
Show member pathways
13.05 IL2 IL4 IL6 TLR2 TLR4 TNF
10
Show member pathways
13.05 CD86 CXCL10 IFNG IL10 IL2 IL6
11
Show member pathways
13 CD86 CTLA4 IFNG IL10 IL2 IL4
12
Show member pathways
12.89 CXCL10 IFNG IL2 IL4 IL6 MYD88
13 12.86 IFNG IL2 IL4 IL5 IL6
14
Show member pathways
12.85 CXCL10 IFNG IL6 MYD88 TLR4 TNF
15
Show member pathways
12.8 IL2 IL6 MYD88 TLR2 TLR4 TNF
16
Show member pathways
12.73 CD86 IFNG IL10 IL2 IL4 TNF
17
Show member pathways
12.66 IFNG IL10 IL2 IL6 TNF
18 12.6 CTLA4 CXCL10 IFNG IL10 IL2 IL4
19
Show member pathways
12.59 MYD88 TLR2 TLR4 TNF
20
Show member pathways
12.55 CTLA4 IFNG IL10 IL2 IL4 IL5
21
Show member pathways
12.53 IFNG IL2 IL4 TNF
22
Show member pathways
12.52 IFNG IL10 IL2 IL4 IL5 IL6
23
Show member pathways
12.5 CXCL10 IFNG IL4 IL5 IL6 TLR2
24
Show member pathways
12.44 IFNG IL2 IL4 IL6 TNF
25
Show member pathways
12.41 IFNG IL6 MYD88 TLR4 TNF
26 12.41 CXCL10 IL6 MYD88 TLR2 TNF
27
Show member pathways
12.41 IFNG IL10 IL2 IL4 IL5 IL6
28
Show member pathways
12.41 IFNG IL10 IL4 MYD88 TLR2 TLR4
29
Show member pathways
12.39 CD86 IFNG IL10 IL2 IL4 IL5
30
Show member pathways
12.38 IL6 MYD88 TLR2 TLR4 TNF
31 12.36 IFNG IL10 IL6 MYD88 TLR2 TLR4
32
Show member pathways
12.33 IL10 IL2 IL6 MYD88 TNF
33 12.31 IFNG IL6 TLR2 TLR4 TNF
34
Show member pathways
12.28 IL6 MYD88 TLR2 TNF
35
Show member pathways
12.22 IFNG IL4 IL6 TLR2 TLR4 TNF
36
Show member pathways
12.22 CXCL10 IFNG IL4 IL6 MYD88 TLR2
37
Show member pathways
12.18 IFNG IL10 IL2 IL4 IL5 IL6
38 12.13 CXCL10 IFNG IL2 IL4 IL6 TLR4
39
Show member pathways
12.12 IL2 IL5 TLR2 TLR4
40 12.08 IL10 IL4 IL6 TNF
41 12.08 IFNG IL10 IL6 TLR2 TLR4 TNF
42
Show member pathways
12.08 CD86 IFNG IL10 IL2 IL6 TLR2
43 12.01 IL4 IL5 IL6 TNF
44
Show member pathways
11.99 IFNG IL2 IL4
45 11.99 CD86 IFNG IL10 IL2 IL4 IL5
46 11.98 IFNG IL2 IL4 IL5 IL6
47 11.97 CXCL10 IL6 TNF
48 11.97 IFNG IL10 IL2 IL6
49 11.96 IFNG IL10 IL2 IL4 IL5 TNF
50 11.96 CD86 CTLA4 IFNG IL6 TLR2 TLR4

GO Terms for Paracoccidioidomycosis

Cellular components related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 CXCL10 IFNG IL10 IL2 IL4 IL5
2 intracellular GO:0005622 9.73 CXCL10 IFNG IL2 IL5 TLR4 TNF
3 extracellular space GO:0005615 9.56 CXCL10 IFNG IL10 IL2 IL4 IL5
4 external side of plasma membrane GO:0009897 9.02 CD86 CTLA4 CXCL10 TLR4 TNF

Biological processes related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.98 IFNG IL4 IL6 MYD88 TLR2 TLR4
2 positive regulation of DNA-binding transcription factor activity GO:0051091 9.93 IL10 IL5 IL6 TNF
3 response to lipopolysaccharide GO:0032496 9.93 CXCL10 IL10 MYD88 TLR2 TLR4
4 response to virus GO:0009615 9.92 CXCL10 IFNG MYD88 TNF
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.92 IL6 MYD88 TLR2 TLR4 TNF
6 defense response to Gram-positive bacterium GO:0050830 9.91 IL6 MYD88 TLR2 TNF
7 positive regulation of JNK cascade GO:0046330 9.9 MYD88 TLR4 TNF
8 positive regulation of inflammatory response GO:0050729 9.89 IL2 TLR2 TLR4 TNF
9 regulation of inflammatory response GO:0050727 9.88 MYD88 TLR4 TNF
10 response to glucocorticoid GO:0051384 9.88 IL10 IL6 TNF
11 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.88 IFNG IL2 IL4 IL6
12 humoral immune response GO:0006959 9.87 IFNG IL6 TNF
13 positive regulation of smooth muscle cell proliferation GO:0048661 9.87 IL6 MYD88 TNF
14 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.86 TLR2 TLR4 TNF
15 positive regulation of tumor necrosis factor production GO:0032760 9.86 MYD88 TLR2 TLR4
16 positive regulation of T cell proliferation GO:0042102 9.86 CD86 IL2 IL4 IL6
17 regulation of signaling receptor activity GO:0010469 9.86 CXCL10 IFNG IL10 IL2 IL4 IL5
18 positive regulation of interferon-gamma production GO:0032729 9.85 IL2 TLR4 TNF
19 positive regulation of nitric oxide biosynthetic process GO:0045429 9.85 IFNG TLR4 TNF
20 negative regulation of T cell proliferation GO:0042130 9.85 CD86 CTLA4 IL10
21 cellular response to lipopolysaccharide GO:0071222 9.85 CD86 CXCL10 IL10 IL6 TLR4 TNF
22 toll-like receptor signaling pathway GO:0002224 9.83 MYD88 TLR2 TLR4
23 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.83 MYD88 TLR2 TLR4
24 negative regulation of interleukin-6 production GO:0032715 9.82 IL10 TLR4 TNF
25 positive regulation of interleukin-12 production GO:0032735 9.81 IFNG TLR2 TLR4
26 positive regulation of B cell proliferation GO:0030890 9.8 IL2 IL4 IL5 TLR4
27 lipopolysaccharide-mediated signaling pathway GO:0031663 9.78 MYD88 TLR2 TLR4 TNF
28 regulation of regulatory T cell differentiation GO:0045589 9.77 CTLA4 IFNG IL2
29 positive regulation of osteoclast differentiation GO:0045672 9.76 IFNG TNF
30 negative regulation of growth of symbiont in host GO:0044130 9.76 IL10 MYD88 TNF
31 positive regulation of interleukin-8 production GO:0032757 9.76 MYD88 TLR2 TLR4 TNF
32 inflammatory response GO:0006954 9.76 CXCL10 IL10 IL5 IL6 MYD88 TLR2
33 positive regulation of T cell differentiation GO:0045582 9.75 IL2 IL4
34 microglial cell activation GO:0001774 9.75 TLR2 TNF
35 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.75 MYD88 TLR4
36 positive regulation of glial cell proliferation GO:0060252 9.75 IL6 TNF
37 positive regulation of macrophage activation GO:0043032 9.75 IL10 TLR4
38 negative regulation of B cell proliferation GO:0030889 9.75 CTLA4 IL10
39 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.75 IFNG TNF
40 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.74 IL10 TNF
41 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.74 TLR2 TLR4
42 positive regulation of interleukin-17 production GO:0032740 9.74 IL2 MYD88
43 regulation of cytokine secretion GO:0050707 9.74 TLR2 TLR4
44 I-kappaB phosphorylation GO:0007252 9.74 TLR2 TLR4
45 negative regulation of interleukin-17 production GO:0032700 9.74 IFNG TLR4
46 positive regulation of podosome assembly GO:0071803 9.74 IL5 TNF
47 positive regulation of immunoglobulin secretion GO:0051024 9.74 IL2 IL5 IL6
48 response to molecule of bacterial origin GO:0002237 9.73 IL10 TLR2
49 cellular response to lipoteichoic acid GO:0071223 9.73 TLR2 TLR4
50 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.73 TLR4 TNF

Molecular functions related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.97 CD86 CTLA4 CXCL10 IFNG IL10 IL2
2 growth factor activity GO:0008083 9.35 IL10 IL2 IL4 IL5 IL6
3 Toll-like receptor binding GO:0035325 9.32 MYD88 TLR2
4 lipopolysaccharide receptor activity GO:0001875 9.26 TLR2 TLR4
5 cytokine activity GO:0005125 9.23 CXCL10 IFNG IL10 IL2 IL4 IL5

Sources for Paracoccidioidomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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