Paracoccidioidomycosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

GARD: ¹⁹ A rare mycosis characterized by an acute form mostly occurring in children and young adults presenting with fever, weight loss, lymph node enlargement, hepatosplenomegaly, and bone marrow dysfunction, versus a chronic form which usually involves the lungs and mucosae of the upper respiratory tract, skin, lymph nodes, and adrenal glands, but may affect any part of the body. The most common sequelae are chronic respiratory insufficiency and Addison's disease. The infectious agent, Paracoccidioides brasiliensis, is a fungus limited to Latin America.

MalaCards based summary: Paracoccidioidomycosis, also known as mucocutaneous-lymphangitic paracoccidioidomycosis, is related to histoplasmosis and cryptococcosis. An important gene associated with Paracoccidioidomycosis is IL10 (Interleukin 10), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include mucosa, lymph nodes and bone, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and homeostasis/metabolism

Orphanet: ⁵⁸ A rare mycosis characterized by an acute form mostly occurring in children and young adults presenting with fever, weight loss, lymph node enlargement, hepatosplenomegaly, and bone marrow dysfunction, versus a chronic form which usually involves the lungs and mucosae of the upper respiratory tract, skin, lymph nodes, and adrenal glands, but may affect any part of the body. The most common sequelae are chronic respiratory insufficiency and Addison's disease. The infectious agent, Paracoccidioides brasiliensis, is a fungus limited to Latin America.

Disease Ontology: ¹¹ A primary systemic mycosis that results in systemic fungal infection located in mucosa, located in lymph nodes, located in bone, located in skin or located in lungs, has material basis in Paracoccidioides brasiliensis.

Wikipedia: ⁷⁵ Paracoccidioidomycosis (PCM), also known as South American blastomycosis, is a fungal infection that can... more...

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Related Diseases for Paracoccidioidomycosis

Diseases related to Paracoccidioidomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 928)

#	Related Disease	Score	Top Affiliating Genes
1	histoplasmosis	31.0	TNF IL12RB1 IFNG
2	cryptococcosis	30.7	TNF IL4 IL10 IFNG
3	sporotrichosis	30.7	TNF IL10 IFNG
4	actinomycosis	30.3	TNF IL10 ALB
5	human immunodeficiency virus type 1	30.1	IL2 IL10 IFNG CXCL10 CD209
6	hypereosinophilic syndrome	30.1	IL5 IL4 IL2 IL10 IFNG CXCL8
7	histiocytosis	30.1	TNF IL4 IFNG
8	extrinsic allergic alveolitis	30.1	TNF IL18 CXCL8 CD28
9	choroiditis	30.0	TNF IL10 IFNG
10	radiculopathy	30.0	IL6 IL5 IL10 CXCL9 CXCL8
11	macs syndrome	30.0	TNF IL12RB1 IL10 IFNG
12	anthracosis	30.0	TNF IL6 CXCL8
13	chronic beryllium disease	29.9	IL18 IFNG
14	acquired immunodeficiency syndrome	29.9	TNF IL6 IL2 IL10 IFNG ALB
15	haemophilus influenzae	29.9	TNF TLR2 CXCL8
16	alcohol use disorder	29.9	TNF TLR4 IL6 ALB
17	strongyloidiasis	29.9	IL5 IL4 IL10 IFNG
18	pneumoconiosis	29.8	TNF IL6 IL10 CXCL8
19	mucormycosis	29.8	TNF IL6 IL10 IFNG
20	lymph node tuberculosis	29.8	TNF IFNG ALB
21	hypopyon	29.8	TNF IL6 IL10
22	fatty liver disease	29.8	TNF TLR4 IL6 IL10
23	aortitis	29.8	TNF IL6 IFNG
24	adult respiratory distress syndrome	29.8	TNF IL6 IL10 CXCL8
25	inflammatory bowel disease 1	29.7	TNF TLR4 TLR2 IL6 IL10
26	intracranial hypertension	29.7	TNF IL6 ALB
27	penicilliosis	29.7	IL12RB1 IFNG
28	myelitis	29.7	TNF IL6 IL10 CXCL8
29	progressive multifocal leukoencephalopathy	29.7	TNF IL2 CTLA4
30	mucocutaneous leishmaniasis	29.6	TNF IL5 IL4 IL2 IL10
31	syphilis	29.6	TNF TLR2 CD209 ALB
32	silicosis	29.6	TNF TLR4 IL4 IL18 IL10 CXCL8
33	myositis	29.6	TNF IL6 IFNG CXCL10
34	hydrocephalus	29.6	TNF TLR4 IL10 IFNG
35	varicose veins	29.6	TNF IL6 CXCL8
36	neuromyelitis optica	29.5	IL6 IL5 IL4 CXCL10
37	retinal detachment	29.5	TNF IL6 IL10 IFNG CXCL8 CXCL10
38	serum amyloid a amyloidosis	29.5	TNF IL6 ALB
39	pulmonary emphysema	29.5	IL18 IFNG CXCL8 ALB
40	headache	29.5	TNF IL2 CXCL8 ALB
41	vasculitis	29.5	TNF IL6 IL10 CXCL8 CTLA4
42	bacterial meningitis	29.5	TNF TLR4 TLR2 IL10 CXCL8
43	intermittent claudication	29.5	IL6 IL10 ALB
44	meningoencephalitis	29.5	TNF IL6 IL10 CXCL10 ALB
45	interstitial lung disease	29.5	TNF IL6 IL4 IL18 IL10 IFNG
46	intestinal obstruction	29.5	TNF IL6 ALB
47	urinary tract obstruction	29.5	TNF IL6 ALB
48	erysipelas	29.4	TNF IL6 IL2
49	bowel dysfunction	29.4	TNF IL6 IL10 ALB
50	substance abuse	29.4	TNF TLR4 IL6 ALB

Graphical network of the top 20 diseases related to Paracoccidioidomycosis:

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Symptoms & Phenotypes for Paracoccidioidomycosis

GenomeRNAi Phenotypes related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.15	ALB CD209 CD28 CD86 CTLA4 CXCL10
2	no effect	GR00402-S-2	10.15	ALB CD209 CD28 CD86 CTLA4 CXCL10
3	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-1	9.77	CD28 CXCL8 IL10 IL18 MYD88 TNF
4	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-2	9.77	CD28 CXCL8 IL10 IL18 IL2 MYD88

MGI Mouse Phenotypes related to Paracoccidioidomycosis:

⁴⁵ (show all 16)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.47	ALB CD209 CD28 CD86 CTLA4 CXCL10
2	immune system	MP:0005387	10.35	ALB CD209 CD28 CD86 CTLA4 CXCL10
3	nervous system	MP:0003631	10.33	CD28 CD86 CXCL10 IFNG IL10 IL18
4	digestive/alimentary	MP:0005381	10.33	ALB CD209 CD28 CTLA4 IFNG IL10
5	cellular	MP:0005384	10.31	ALB CD209 CD28 CD86 CXCL10 IFNG
6	neoplasm	MP:0002006	10.3	ALB CD28 IFNG IL10 IL2 IL5
7	liver/biliary system	MP:0005370	10.3	ALB CTLA4 IFNG IL10 IL2 IL4
8	endocrine/exocrine gland	MP:0005379	10.26	ALB CD28 CD86 CTLA4 IFNG IL10
9	muscle	MP:0005369	10.19	ALB CD86 IFNG IL10 IL18 IL6
10	cardiovascular system	MP:0005385	10.18	ALB CTLA4 CXCL10 IFNG IL10 IL18
11	adipose tissue	MP:0005375	10.11	CD209 IL12RB1 IL18 IL6 MYD88 TLR2
12	hematopoietic system	MP:0005397	10.11	CD209 CD28 CD86 CTLA4 CXCL10 CXCL9
13	respiratory system	MP:0005388	10.06	CTLA4 IFNG IL10 IL2 IL4 IL5
14	vision/eye	MP:0005391	10	CD28 IFNG IL10 IL12RB1 IL18 IL2
15	mortality/aging	MP:0010768	9.83	ALB CD209 CTLA4 CXCL10 CXCL9 IFNG
16	integument	MP:0010771	9.4	CD28 CTLA4 IFNG IL10 IL12RB1 IL18

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Drugs & Therapeutics for Paracoccidioidomycosis

Search Clinical Trials, NIH Clinical Center for Paracoccidioidomycosis

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Itraconazole

Ketoconazole

Cochrane evidence based reviews: paracoccidioidomycosis

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Genetic Tests for Paracoccidioidomycosis

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Anatomical Context for Paracoccidioidomycosis

Organs/tissues related to Paracoccidioidomycosis:

FMA: Mucosa, Lymph Nodes, Bone, Skin, Lungs

MalaCards : Lymph Node, Bone Marrow, Skin, Bone, Spleen, Liver, T Cells

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Publications for Paracoccidioidomycosis

Articles related to Paracoccidioidomycosis:

(show top 50) (show all 2204)

#	Title	Authors	PMID	Year
1	Role of TLR2 and TLR4 in human neutrophil functions against Paracoccidioides brasiliensis. ⁵³ ⁶²	Acorci-Valerio MJ...de Campos Soares AM	20384861	2010
2	Altered expression of the costimulatory molecules CD80, CD86, CD152, PD-1 and ICOS on T-cells from paracoccidioidomycosis patients: lack of correlation with T-cell hyporesponsiveness. ⁵³ ⁶²	Cacere CR...Benard G	18757242	2008
3	Serum interleukin-18 and soluble tumour necrosis factor receptor 2 are associated with disease severity in patients with paracoccidioidomycosis. ⁵³ ⁶²	Corvino CL...Blotta MH	17302897	2007
4	Kinetics of IFN-gamma, TNF-alpha, IL-10 and IL-4 production by mononuclear cells stimulated with gp43 peptides, in patients cured of paracoccidioidomycosis. ⁵³ ⁶²	Sadahiro A...Shikanai-Yasuda MA	17568881	2007
5	Interleukin-10 and tumor necrosis factor-alpha single nucleotide gene polymorphism frequency in paracoccidioidomycosis. ⁵³ ⁶²	Bozzi A...Goes AM	17145373	2006
6	Cytokines released from blood monocytes and expressed in mucocutaneous lesions of patients with paracoccidioidomycosis evaluated before and during trimethoprim-sulfamethoxazole treatment. ⁵³ ⁶²	Parise-Fortes MR...Peracoli MT	16536806	2006
7	The role of interleukin-10 in the differential expression of interleukin-12p70 and its beta2 receptor on patients with active or treated paracoccidioidomycosis and healthy infected subjects. ⁵³ ⁶²	Romano CC...Benard G	15596413	2005
8	Modulation of CD28 and CD86 expression in patients with paracoccidioidomycosis in different periods of treatment. ⁵³ ⁶²	Bozzi A...Goes AM	15541043	2004
9	Proteomic identification, nucleotide sequence, heterologous expression and immunological reactivity of the triosephosphate isomerase of Paracoccidioides brasiliensis. ⁵³ ⁶²	Pereira LA...Soares CM	15310465	2004
10	Fas-Fas ligand (CD95-CD95L) and cytotoxic T lymphocyte antigen-4 engagement mediate T cell unresponsiveness in patients with paracoccidioidomycosis. ⁵³ ⁶²	Campanelli AP...Silva JS	12717632	2003
11	Dendritic cells and pattern of cytokines in paracoccidioidomycosis skin lesions. ⁵³ ⁶²	Pagliari C...Sotto MN	12652191	2003
12	Heterologous expression, purification, and immunological reactivity of a recombinant HSP60 from Paracoccidioides brasiliensis. ⁵³ ⁶²	Cunha DA...Soares CM	11874881	2002
13	Molecular cloning, characterization and expression of the heat shock protein 60 gene from the human pathogenic fungus Paracoccidioides brasiliensis. ⁵³ ⁶²	Izacc SM...Soares CM	12054056	2001
14	High serum interleukin-10 and tumor necrosis factor alpha levels in chronic paracoccidioidomycosis. ⁵³ ⁶²	Fornari MC...Diez RA	11527826	2001
15	Imbalance of IL-2, IFN-gamma and IL-10 secretion in the immunosuppression associated with human paracoccidioidomycosis. ⁵³ ⁶²	Benard G...Duarte AJ	11237434	2001
16	The Impact of Paracoccidioides spp Infection on Central Nervous System Cell Junctional Complexes. ⁶²	de Almeida SM...de Noronha L	35922705	2022
17	Virtual screening and repurposing of approved drugs targeting homoserine dehydrogenase from Paracoccidioides brasiliensis. ⁶²	da Cruz EC...Siqueira AS	36323986	2022
18	Using infrared spectroscopy of serum and chemometrics for diagnosis of paracoccidioidomycosis. ⁶²	Koehler A...Corbellini VA	36113324	2022
19	A lateral flow assay for the immunodiagnosis of human cat-transmitted sporotrichosis. ⁶²	Cognialli R...Queiroz-Telles F	35943444	2022
20	Severe paracoccidioidomycosis, with a fatal outcome and incidence related to an environmental event. ⁶²	Stringuini FA...Martins CJ	36253243	2022
21	Kidney impairment in a child with acute-subacute paracoccidioidomycosis: Answers. ⁶²	das Neves Romaneli MT...Pereira RM	36214887	2022
22	Kidney impairment in a child with acute-subacute paracoccidioidomycosis: Questions. ⁶²	das Neves Romaneli MT...Pereira RM	36214885	2022
23	Paracoccidioidomycosis: What We Know and What Is New in Epidemiology, Diagnosis, and Treatment. ⁶²	Pecanha PM...Goncalves SS	36294662	2022
24	[Oral paracoccidiodomycosis in an immunocompetent woman: a case report and literature review]. ⁶²	Reyes-Correa AJ...Garcia-Ayala E	36154729	2022
25	Systematic review of neuroparacoccidioidomycosis: The contribution of neuroimaging. ⁶²	de Oliveira VF...Silva GD	36062632	2022
26	Combined Silymarin and Cotrimoxazole Therapy Attenuates Pulmonary Fibrosis in Experimental Paracoccidioidomycosis. ⁶²	Resende VQ...Venturini J	36294575	2022
27	Paracoccidioidomycosis screening diagnosis by FTIR spectroscopy and multivariate analysis. ⁶²	de Brito ECA...Cena C	35598713	2022
28	Paracoccidioidomycosis: Current Status and Future Trends. ⁶²	Hahn RC...de Camargo ZP	36074014	2022
29	Immunologic Diagnosis of Endemic Mycoses. ⁶²	Almeida-Paes R...Zancope-Oliveira RM	36294558	2022
30	Head and neck manifestations of paracoccidioidomycosis: A retrospective study of histopathologically diagnosed cases in two medical centers in southern Brazil. ⁶²	Koehler A...Scroferneker ML	35580434	2022
31	Proteomic alterations in Paracoccidioides brasiliensis caused by exposure to curcumin. ⁶²	Rocha OB...Pereira M	35835316	2022
32	Performance of Two Commercial Assays for the Detection of Serum Aspergillus Galactomannan in Non-Neutropenic Patients. ⁶²	Almeida-Paes R...Zancope-Oliveira RM	35887496	2022
33	Paracoccidioidomycosis in people living with HIV/AIDS: A historical retrospective cohort study in a national reference center for infectious diseases, Rio de Janeiro, Brazil. ⁶²	Falcao EM...do Valle ACF	35704666	2022
34	Phototherapies as an adjuvant treatment for oral paracoccidioidomycosis. ⁶²	Guirado MG...Campos L	35183781	2022
35	PbGP43 Genotyping Using Paraffin-Embedded Biopsies of Human Paracoccidioidomycosis Reveals a Genetically Distinct Lineage in the Paracoccidioides brasiliensis Complex. ⁶²	Ricci G...Batista WL	34870754	2022
36	Clinical and Eco-Epidemiological Aspects of a Novel Hyperendemic Area of Paracoccidioidomycosis in the Tocantins-Araguaia Basin (Northern Brazil), Caused by Paracoccidioides sp. ⁶²	Krakhecke-Teixeira AG...Teixeira MM	35628757	2022
37	The Multifaceted Role of Mating Type of the Fungus and Sex of the Host in Studies of Fungal Infections in Humans. ⁶²	Krasevec N	35628717	2022
38	Compulsory notification of paracoccidioidomycosis: A 14-year retrospective study of the disease in the state of Paraná, Brazil. ⁶²	de Suguiura IMS...Ono MA	34936142	2022
39	Lobomycosis and paracoccidioidomycosis meet again. ⁶²	Cabanes FJ	35283022	2022
40	Mixed infection by Cryptococcus neoformans and Cryptococcus gattii and coinfection with paracoccidioidomycosis in PLHIV. ⁶²	de Faria Ferreira M...Trilles L	35256962	2022
41	Paracoccidioidomycosis Simulating Eyelid Carcinoma. ⁶²	Peruzzo J...Procianoy PDC	35429963	2022
42	Photodynamic therapy in the treatment of oral lesions caused by paracoccidiomycosis. ⁶²	Santos DSA...Franco JB	34823032	2022
43	Biochemical characterization and analysis of gene expression of an α-mannosidase secreted by Paracoccidioides brasiliensis. ⁶²	Correa PC...Panunto-Castelo A	35076076	2022
44	Intestinal Paracoccidioidomycosis: Case report and literature review. ⁶²	Giron F...Ortega J	35121286	2022
45	Pulmonary and cerebral paracoccidioidomycosis. ⁶²	Machado MGL...Marchiori E	36134863	2022
46	Disseminated paracoccidioidomycosis associated with lymph node tuberculosis in a non immunocompromised child. ⁶²	Montalvo R...Tunque E	35663608	2022
47	A scoping study of pulmonary paracoccidioidomycosis: severity classification based on radiographic and tomographic evaluation. ⁶²	Ribeiro SM...Mendes RP	36465893	2022
48	Chronic exposure to cigarette smoke transiently worsens the disease course in a mouse model of pulmonary paracoccidioidomycosis. ⁶²	Buccheri R...Benard G	36383893	2022
49	Disseminated paracoccidioidomycosis with skull and mandible involvement in a heart transplant recipient. ⁶²	Pereira FV...Reis F	35674557	2022
50	Paracoccidioidomycosis with sarcoid-like cutaneous lesion: A clinicopathological challenge. ⁶²	Carcano CBM...Ferreira MS	35923859	2022

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Genes for Paracoccidioidomycosis

Genes related to Paracoccidioidomycosis (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	IL10	Interleukin 10	Protein Coding	21.01	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	17145373 16536806 15596413 (more) 11527826 17568881 12652191 11237434 20384861
2	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	17.68	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	18757242 12717632
3	CXCL9	C-X-C Motif Chemokine Ligand 9	Protein Coding	16.57	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	17302897
4	CD28	CD28 Molecule	Protein Coding	15.82	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15541043 18757242
5	CXCL10	C-X-C Motif Chemokine Ligand 10	Protein Coding	15	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	17302897
6	TNF	Tumor Necrosis Factor	Protein Coding	14.43	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
7	IL4	Interleukin 4	Protein Coding	13.92	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
8	TLR2	Toll Like Receptor 2	Protein Coding	13.39	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
9	IFNG	Interferon Gamma	Protein Coding	13.19	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
10	TLR4	Toll Like Receptor 4	Protein Coding	13.03	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
11	IL12RB1	Interleukin 12 Receptor Subunit Beta 1	Protein Coding	12.95	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
12	IL5	Interleukin 5	Protein Coding	12.91	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
13	CD209	CD209 Molecule	Protein Coding	12.59	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
14	IL6	Interleukin 6	Protein Coding	12.55	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
15	CD86	CD86 Molecule	Protein Coding	12.51	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
16	IL2	Interleukin 2	Protein Coding	12.38	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
17	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	12.32	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
18	IL18	Interleukin 18	Protein Coding	12.26	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
19	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	12.25	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
20	ALB	Albumin	Protein Coding	11.98	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)

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Variations for Paracoccidioidomycosis

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Expression for Paracoccidioidomycosis

Search GEO for disease gene expression data for Paracoccidioidomycosis.

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Pathways for Paracoccidioidomycosis

Pathways related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

(show top 50) (show all 91)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	14.07	TNF TLR4 TLR2 MYD88 IL6 IL5
2	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.96	TNF IL6 IL5 IL4 IL2 IL18
3	Signal Transduction ⁶⁶	13.87	TNF MYD88 IL6 IL5 IL2 CXCL9
4	MIF Mediated Glucocorticoid Regulation ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ Overview of proinflammatory and profibrotic mediators ⁷⁴ PEDF Induced Signaling ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.79	TNF TLR4 IL6 IL5 IL4 IL2
5	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.67	TNF IL6 IL5 IL4 IL2 IL18
6	Prolactin Signaling ⁶⁴ Show member pathways Development Prolactin receptor signaling ²² EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ⁷⁴ ErbB Family Pathway ⁶⁴ ErbB signaling pathway ⁷⁴ ErbB2-ErbB3 Heterodimers ⁶⁴ ErbB4 Pathway ⁶⁴ Estrogen-stimulated signaling through PRKCZ ⁶⁶ Glioblastoma Multiforme ⁶⁴ Glioblastoma signaling pathways ⁷⁴ Growth Hormone Signaling ⁶⁴ HMGB1 Pathway ⁶⁴ IL-2 Pathway ⁶⁴ LPS Stimulated MAPK Signaling ⁶⁴ PACAP Signaling ⁶⁴ PI3K Signaling in B-Lymphocyte ⁶⁴ TCA cycle nutrient use and invasiveness of ovarian cancer ⁷⁴ Thrombopoietin Pathway ⁶⁴ TREM1 Pathway ⁶⁴ UVA-Induced MAPK Signaling ⁶⁴ UVB-Induced MAPK Signaling ⁶⁴ UVC-Induced MAPK Signaling ⁶⁴	13.55	IFNG IL2 IL4 IL6 MYD88 TLR2
7	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.5	CD86 CXCL10 CXCL8 IFNG IL10 IL12RB1
8	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.5	TNF TLR4 TLR2 MYD88 IL6 IL5
9	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.48	CD28 CXCL10 CXCL8 CXCL9 IL10 IL12RB1
10	Toll-like receptor signaling pathway ⁷⁴ Show member pathways Hepatitis B infection ⁷⁴ Measles virus infection ⁷⁴ Regulation of toll-like receptor signaling pathway ⁷⁴	12.96	CD209 CD28 CD86 CXCL10 CXCL8 CXCL9
11	NF-KappaB Family Pathway ⁶⁴ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁴	12.84	TNF TLR4 TLR2 MYD88 IL6 IL2
12	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.84	TNF IL6 IL5 IL4 IL2 IL18
13	IL-1 Family Signaling Pathways ⁶⁵ Show member pathways IL1 signaling pathway ⁶⁷ Immune response IL-1 signaling pathway ²² Interleukin-1 (IL-1) structural pathway ⁷⁴ Interleukin-33 signaling ⁶⁶ Interleukin-36 pathway ⁶⁶ Mucin expression in CF via TLRs, EGFR signaling pathways ²² Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁵	12.8	TNF TLR2 MYD88 IL6 IL18 CXCL8
14	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.79	TNF IL6 IL2 IL18 IL12RB1 IL10
15	NF-kappaB Signaling ³	12.76	CD28 CTLA4 CXCL10 IFNG IL10 IL2
16	Toll-Like receptor Signaling Pathways ⁶⁵ Show member pathways Inflammasome Activation Pathways ⁶⁵ Nanomaterial-induced inflammasome activation ⁷⁴ NOD-like Receptor Signaling Pathways ⁶⁵ TLR4 signaling and tolerance ⁷⁴ Toll-Like Receptors Pathway ⁶⁴	12.72	TNF TLR4 TLR2 MYD88 IL6 IL18
17	Bacterial infections in CF airways ²² Show member pathways Altered glycosylation of MUC1 in tumor microenvironment ⁷⁴ IL-1 beta-dependent CFTR expression ²² IL1-mediated signaling events ⁶¹ Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²² NTHi-Induced Signaling ⁶⁴ Signal transduction through IL1R ⁷⁴	12.65	TNF TLR4 TLR2 MYD88 IL6 IL4
18	DDX58/IFIH1-mediated induction of interferon-alpha/beta ⁶⁶ Show member pathways Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway ²² Negative regulators of DDX58/IFIH1 signaling ⁶⁶ NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 ⁶⁶ Novel intracellular components of RIG-I-like receptor pathway ⁷⁴ SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation ⁷⁴ TRAF3-dependent IRF activation pathway ⁶⁶ TRAF6 mediated IRF7 activation ⁶⁶	12.5	TLR4 IFNG CXCL8 CXCL10
19	Toll Comparative Pathway ⁶⁴ Show member pathways IL-1 Pathway ⁶⁴ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶⁴ TLR-TRIF Pathway ⁶⁴	12.5	CXCL8 IFNG IL6 MYD88 TLR4 TNF
20	Cytosolic sensors of pathogen-associated DNA ⁶⁶ Show member pathways Cytosolic DNA-sensing pathway ⁷⁴ DEx/H-box helicases activate type I IFN and inflammatory cytokines production ⁶⁶ IkBA variant leads to EDA-ID ⁶⁶ IRF3 mediated activation of type 1 IFN ⁶⁶ IRF3-mediated induction of type I IFN ⁶⁶ LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production ⁶⁶ Regulation by TREX1 ⁶⁶ Regulation of innate immune responses to cytosolic DNA ⁶⁶ RIP-mediated NFkB activation via ZBP1 ⁶⁶ Selenium micronutrient network ⁷⁴ STAT6-mediated induction of chemokines ⁶⁶ STING mediated induction of host immune responses ⁶⁶ ZBP1(DAI) mediated induction of type I IFNs ⁶⁶	12.47	MYD88 IL6 IL18 CXCL10
21	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ⁶⁷ IL-17 signaling pathway ⁷⁴ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.42	TNF TLR2 IL6 CXCL8 CXCL10
22	Colorectal Cancer Metastasis ⁶⁴	12.35	TNF TLR4 TLR2 IL6 IFNG
23	CD28 Signaling in T-Helper Cell ⁶⁴ Show member pathways ICos-ICosL Pathway in T-Helper Cell ⁶⁴	12.34	IL2 CTLA4 CD86 CD28
24	Immune response CD16 signaling in NK cells ²² Show member pathways Immune response Role of DAP12 receptors in NK cells ²²	12.28	TNF IL4 IL2 IFNG
25	Immune response Antigen presentation by MHC class II ²² Show member pathways G-protein signaling N-RAS regulation pathway ²² IL-22 Pathway ⁶⁴ Immune response IL-22 signaling pathway ²²	12.28	IL2 IL12RB1 CD86 CD28
26	Neuroinflammation and glutamatergic signaling ⁷⁴	12.27	TNF IL6 IL4 IL10 IFNG
27	Sudden infant death syndrome (SIDS) susceptibility pathways ⁷⁴	12.26	TNF IL6 IL10 CXCL8
28	Spinal cord injury ⁷⁴	12.23	TNF TLR4 IL6 IL4 IL2 IFNG
29	Interleukin-4 and Interleukin-13 signaling ⁶⁶	12.18	TNF IL6 IL4 IL18 IL10 CXCL8
30	IL12-mediated signaling events ⁶¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²²	12.16	IL4 IL2 IL18 IL12RB1 IFNG
31	MAPK Pathway ⁷⁰ Show member pathways Toll-like Receptor Pathway ⁷⁰	12.13	IL2 IL5 TLR2 TLR4
32	Cytokine production by Th17 cells in CF (Mouse model) ²² Show member pathways Cytokine production by Th17 cells in CF ²²	12.08	CXCL8 IL12RB1 IL6 MYD88 TLR4
33	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	12.08	CD28 CD86 CTLA4 IFNG IL10 IL12RB1
34	Th17 Differentiation ⁶⁵ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	12.07	TLR4 TLR2 IL6 IL4 IL12RB1 IFNG
35	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	12.06	TNF TLR4 TLR2 IL6 IL2 IL18
36	Glucocorticoid receptor regulatory network ⁶¹	12.02	IL6 IL5 IL4 IL2 IFNG CXCL8
37	Corticotropin-releasing hormone signaling pathway ⁷⁴	12	TLR4 IL2 IL18 CXCL8
38	Dendritic Cells Developmental Lineage Pathway ⁶⁵	12	TNF IL6 IL2 IL10 IFNG CD209
39	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	12	TNF TLR4 IL6 IL4 IL2 IL10
40	Innate Lymphoid Cells Differentiation ⁶⁵	12	IFNG IL10 IL12RB1 IL18 IL2 IL4
41	Burn wound healing ⁷⁴	11.97	TNF TLR4 MYD88 IL6 CXCL8
42	Acute viral myocarditis ⁷⁴	11.97	TLR4 IL6 IL2 IL10 IFNG
43	AP-1 transcription factor network ⁶¹	11.97	IL6 IL5 IL4 IL2 IL10 IFNG
44	Allograft rejection ⁷⁴	11.97	TNF IL5 IL4 IL2 IL10 IFNG
45	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ⁶¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ⁶¹	11.95	CTLA4 CXCL8 IFNG IL2 IL4 IL5
46	miRNAs involvement in the immune response in sepsis ⁷⁴	11.92	TNF TLR4 MYD88 IL6 IL10 CXCL8
47	Lung fibrosis ⁷⁴	11.89	CXCL8 IL4 IL5 IL6 TNF
48	Photodynamic therapy-induced NF-kB survival signaling ⁷⁴ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.89	CXCL8 IFNG IL2 IL6 TNF
49	IL 10 signaling pathway ⁶⁷	11.88	TNF TLR4 MYD88 IL6 IL10
50	Inflammatory bowel disease signaling ⁷⁴ Show member pathways Ulcerative colitis signaling ⁷⁴	11.88	TLR2 IL6 IL5 IL4 IL2 IL18

Sources

GO Terms for Paracoccidioidomycosis

Cellular components related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	10.27	ALB CD209 CXCL10 CXCL8 CXCL9 IFNG
2	extracellular space	GO:0005615	10.03	ALB CXCL10 CXCL8 CXCL9 IFNG IL10
3	external side of plasma membrane	GO:0009897	9.58	TNF TLR4 IL12RB1 CXCL9 CXCL10 CTLA4
4	protein complex involved in cell adhesion	GO:0098636	9.56	CTLA4 CD28

Biological processes related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

(show top 50) (show all 66)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription by RNA polymerase II	GO:0045944	10.67	TNF TLR4 TLR2 IL6 IL4 IL2
2	positive regulation of cell population proliferation	GO:0008284	10.5	IL6 IL5 IL4 IL2 IFNG CXCL10
3	negative regulation of apoptotic process	GO:0043066	10.5	ALB CD28 IL10 IL2 IL4 IL6
4	signal transduction	GO:0007165	10.5	CXCL10 CXCL8 CXCL9 IFNG IL10 IL12RB1
5	defense response to virus	GO:0051607	10.4	CXCL10 CXCL9 IFNG IL6 MYD88 TLR2
6	positive regulation of gene expression	GO:0010628	10.38	CD28 CXCL8 IFNG IL18 IL4 IL6
7	defense response to Gram-positive bacterium	GO:0050830	10.36	TNF TLR2 MYD88 IL6 IL18
8	positive regulation of NF-kappaB transcription factor activity	GO:0051092	10.36	IL18 IL6 MYD88 TLR2 TLR4 TNF
9	positive regulation of tumor necrosis factor production	GO:0032760	10.34	IFNG IL6 MYD88 TLR2 TLR4
10	positive regulation of DNA-binding transcription factor activity	GO:0051091	10.33	TNF IL6 IL5 IL10
11	positive regulation of inflammatory response	GO:0050729	10.33	TNF TLR4 TLR2 IL2 IL18 IFNG
12	positive regulation of type II interferon production	GO:0032729	10.32	IL12RB1 IL18 IL2 TLR4 TNF
13	cellular response to type II interferon	GO:0071346	10.31	TNF TLR4 TLR2 IL12RB1
14	positive regulation of interleukin-6 production	GO:0032755	10.3	IFNG IL6 MYD88 TLR2 TLR4 TNF
15	inflammatory response	GO:0006954	10.3	CXCL10 CXCL8 CXCL9 IL18 IL5 IL6
16	positive regulation of cytokine production	GO:0001819	10.28	TNF IL10 IFNG CD28
17	positive regulation of NIK/NF-kappaB signaling	GO:1901224	10.28	CD86 IL18 TLR2 TLR4 TNF
18	humoral immune response	GO:0006959	10.27	TNF IL6 IFNG CD28
19	positive regulation of interleukin-8 production	GO:0032757	10.27	TNF TLR4 TLR2 MYD88 IL6
20	positive regulation of interleukin-1 beta production	GO:0032731	10.27	TNF TLR4 MYD88 IL6 IFNG
21	positive regulation of B cell proliferation	GO:0030890	10.26	TLR4 IL5 IL4 IL2
22	positive regulation of smooth muscle cell proliferation	GO:0048661	10.26	IL18 IL6 MYD88 TLR4 TNF
23	positive regulation of receptor signaling pathway via JAK-STAT	GO:0046427	10.23	TNF IL6 IL5 IL10
24	immune system process	GO:0002376	10.22	TLR4 TLR2 MYD88 IL2 CTLA4 CD86
25	negative regulation of T cell proliferation	GO:0042130	10.21	IL10 CTLA4 CD86
26	positive regulation of interleukin-12 production	GO:0032735	10.21	TLR4 TLR2 IFNG
27	microglial cell activation	GO:0001774	10.21	IFNG IL4 TLR2 TNF
28	positive regulation of cytokine production involved in inflammatory response	GO:1900017	10.21	IL6 MYD88 TLR4 TNF
29	positive regulation of interleukin-10 production	GO:0032733	10.21	TLR4 TLR2 IL6 IL4 CD28
30	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	10.21	IFNG IL18 IL2 IL4 IL6 TNF
31	positive regulation of nitric oxide biosynthetic process	GO:0045429	10.2	TNF TLR4 IFNG
32	response to virus	GO:0009615	10.2	TNF MYD88 IFNG CXCL10
33	positive regulation of interleukin-17 production	GO:0032740	10.2	MYD88 IL6 IL2 IL18
34	liver regeneration	GO:0097421	10.19	TNF IL6 IL10
35	lipopolysaccharide-mediated signaling pathway	GO:0031663	10.19	TNF TLR4 TLR2 MYD88 IL18
36	positive regulation of activated T cell proliferation	GO:0042104	10.18	IL2 IL18 IL12RB1
37	negative regulation of myoblast differentiation	GO:0045662	10.18	TNF IL18 CXCL10
38	MyD88-dependent toll-like receptor signaling pathway	GO:0002755	10.16	TLR4 TLR2 MYD88
39	positive regulation of nitric-oxide synthase biosynthetic process	GO:0051770	10.16	TLR4 TLR2 IFNG
40	positive regulation of immunoglobulin production	GO:0002639	10.16	IL6 IL5 IL2 IL10 CD86
41	response to lipopolysaccharide	GO:0032496	10.14	TNF TLR4 TLR2 MYD88 IL10 CXCL10
42	positive regulation of MHC class II biosynthetic process	GO:0045348	10.14	TLR4 IL4 IL10 IFNG
43	defense response	GO:0006952	10.12	TNF CXCL9 CXCL8 CXCL10
44	positive regulation of neuroinflammatory response	GO:0150078	10.12	TNF IL6 IL18
45	positive regulation of isotype switching to IgG isotypes	GO:0048304	10.12	IL4 IL2 CD28
46	positive regulation of T cell proliferation	GO:0042102	10.11	IL6 IL4 IL2 CD86 CD28 CD209
47	type 2 immune response	GO:0042092	10.1	IL4 IL18 IL10
48	cellular response to lipopolysaccharide	GO:0071222	10.09	TNF TLR4 MYD88 IL6 IL10 CXCL9
49	response to molecule of bacterial origin	GO:0002237	10.05	TLR2 IL10 CXCL8
50	positive regulation of oxidative stress-induced neuron death	GO:1903223	10.04	TNF TLR4

Molecular functions related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	growth factor activity	GO:0008083	9.85	IL6 IL5 IL4 IL2 IL10
2	Toll-like receptor binding	GO:0035325	9.67	TLR2 MYD88
3	CXCR3 chemokine receptor binding	GO:0048248	9.62	CXCL9 CXCL10
4	cytokine activity	GO:0005125	9.62	TNF IL6 IL5 IL4 IL2 IL18
5	lipopolysaccharide immune receptor activity	GO:0001875	9.56	TLR4 TLR2
6	CXCR chemokine receptor binding	GO:0045236	9.43	CXCL10 CXCL8 CXCL9

Sources

Sources for Paracoccidioidomycosis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

PCM MCID: PRC002 MIFTS: 54	Paracoccidioidomycosis (PCM) Categories: Bone diseases, Infectious diseases, Rare diseases, Respiratory diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
Genes Tissues Related diseases Publications Drugs Expand all tables

Paracoccidioidomycosis (PCM)

Aliases & Classifications for Paracoccidioidomycosis

MalaCards integrated aliases for Paracoccidioidomycosis:

Characteristics:

Age Of Onset:

Classifications:

External Ids:

Summaries for Paracoccidioidomycosis

Related Diseases for Paracoccidioidomycosis

Diseases related to Paracoccidioidomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Paracoccidioidomycosis:

Symptoms & Phenotypes for Paracoccidioidomycosis

GenomeRNAi Phenotypes related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Paracoccidioidomycosis:

Drugs & Therapeutics for Paracoccidioidomycosis

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Cochrane evidence based reviews: paracoccidioidomycosis

Genetic Tests for Paracoccidioidomycosis

Anatomical Context for Paracoccidioidomycosis

Organs/tissues related to Paracoccidioidomycosis:

Publications for Paracoccidioidomycosis

Articles related to Paracoccidioidomycosis:

Genes for Paracoccidioidomycosis

Genes related to Paracoccidioidomycosis (0 elite genes):

Variations for Paracoccidioidomycosis

Expression for Paracoccidioidomycosis

Pathways for Paracoccidioidomycosis

Pathways related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

GO Terms for Paracoccidioidomycosis

Cellular components related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

Biological processes related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

Molecular functions related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

Sources for Paracoccidioidomycosis

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :