PCM
MCID: PRC002
MIFTS: 59

Paracoccidioidomycosis (PCM)

Categories: Bone diseases, Immune diseases, Infectious diseases, Rare diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Paracoccidioidomycosis

MalaCards integrated aliases for Paracoccidioidomycosis:

Name: Paracoccidioidomycosis 12 77 54 60 56 45 15 17 74
Mucocutaneous-Lymphangitic Paracoccidioidomycosis 12
Lutz-Splendore-Almeida Disease 54
South American Blastomycosis 54
Paracoccidioidal Granuloma 54
Paracoccidioidal Mycosis 12
Lobo Disease 54
Lobomycosis 74
Pcm 54

Characteristics:

Orphanet epidemiological data:

60
paracoccidioidomycosis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:12662
ICD9CM 36 116.1
MeSH 45 D010229
NCIt 51 C34891
SNOMED-CT 69 36866003 59925007
ICD10 34 B41 B41.9
MESH via Orphanet 46 D010229
ICD10 via Orphanet 35 B41.0 B41.7 B41.8 more
UMLS via Orphanet 75 C0030409
Orphanet 60 ORPHA73260

Summaries for Paracoccidioidomycosis

Disease Ontology : 12 A primary systemic mycosis that results in systemic fungal infection located in mucosa, located in lymph nodes, located in bone, located in skin or located in lungs, has material basis in Paracoccidioides brasiliensis.

MalaCards based summary : Paracoccidioidomycosis, also known as mucocutaneous-lymphangitic paracoccidioidomycosis, is related to mucocutaneous leishmaniasis and coccidioidomycosis. An important gene associated with Paracoccidioidomycosis is IL10 (Interleukin 10), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include bone, skin and lung, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 77 Paracoccidioidomycosis (PCM) (also known as "Brazilian blastomycosis", "South American blastomycosis",... more...

Related Diseases for Paracoccidioidomycosis

Diseases related to Paracoccidioidomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 370)
# Related Disease Score Top Affiliating Genes
1 mucocutaneous leishmaniasis 30.4 IL10 TNF
2 coccidioidomycosis 30.2 IL10 TLR4
3 acquired immunodeficiency syndrome 30.0 IFNG IL10 IL6 TNF
4 pulmonary tuberculosis 29.9 IFNG IL10 IL4 TLR2 TNF
5 human immunodeficiency virus infectious disease 29.8 IFNG IL10 IL6 TNF
6 osteomyelitis 29.8 IFNG IL10 IL6 TNF
7 arthritis 29.6 IFNG IL10 IL6 TNF
8 schistosomiasis 29.5 IFNG IL10 IL4 IL5 TNF
9 penicilliosis 29.4 CD86 TLR2 TLR4 TNF
10 lung disease 29.1 CXCL10 IL10 IL5 IL6 TLR2 TNF
11 pneumonia 28.7 IL10 IL5 IL6 TLR2 TLR4 TNF
12 leishmaniasis 28.7 IFNG IL10 IL4 IL5 TLR2 TLR4
13 human immunodeficiency virus type 1 28.6 CD209 CXCL10 IFNG IL10 IL6 TNF
14 multiple sclerosis 28.4 CD86 CTLA4 CXCL10 IFNG IL10 IL4
15 aspergillosis 28.0 CD209 IFNG IL10 IL4 IL5 TLR2
16 rheumatoid arthritis 27.9 CD86 CTLA4 IFNG IL10 IL4 IL6
17 systemic lupus erythematosus 27.6 CD86 CTLA4 CXCL10 IFNG IL10 IL4
18 choroiditis 10.5 IL10 TNF
19 trichuriasis 10.5 IL10 TNF
20 transient hypogammaglobulinemia 10.5 IL10 TNF
21 sporotrichosis 10.5 IFNG IL10
22 idiopathic achalasia 10.5 IL10 TNF
23 multifocal choroiditis 10.5 IL10 TNF
24 punctate inner choroidopathy 10.5 IL10 TNF
25 trichosporonosis 10.5 IFNG TNF
26 pericardial tuberculosis 10.5 IFNG IL10
27 blastomycosis 10.5
28 miliary tuberculosis 10.5 IFNG TNF
29 chronic beryllium disease 10.5 IFNG TNF
30 staphylococcal toxic shock syndrome 10.5 IFNG TNF
31 retinitis pigmentosa 22 10.5 IL10 IL4
32 beta-lactam allergy 10.5 IL10 IL4
33 asymptomatic neurosyphilis 10.5 CXCL10 IFNG
34 opisthorchiasis 10.4 IL4 TNF
35 penicillin allergy 10.4 IFNG IL4
36 crustacean allergy 10.4 IFNG IL4
37 necatoriasis 10.4 IL10 IL5
38 eosinophilic fasciitis 10.4 IFNG IL5
39 strongyloidiasis 10.4 IFNG IL5
40 eosinophilia-myalgia syndrome 10.4 IFNG IL5
41 type 1 diabetes mellitus 13 10.4 CD86 CTLA4
42 inflammatory bowel disease 4 10.4 IL4 IL5
43 angiostrongyliasis 10.4 IL4 IL5
44 cough variant asthma 10.4 IL4 IL5
45 egg allergy 10.4 IL4 IL5
46 intrinsic asthma 10.4 IL4 IL5
47 trichinosis 10.4 IL4 IL5
48 congenital cytomegalovirus 10.4 TLR2 TNF
49 haemophilus influenzae 10.4 TLR2 TNF
50 hemophagocytic lymphohistiocytosis 10.3 IFNG IL10 TNF

Graphical network of the top 20 diseases related to Paracoccidioidomycosis:



Diseases related to Paracoccidioidomycosis

Symptoms & Phenotypes for Paracoccidioidomycosis

MGI Mouse Phenotypes related to Paracoccidioidomycosis:

47 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.31 CD86 CTLA4 CXCL10 IFNG IL10 IL4
2 homeostasis/metabolism MP:0005376 10.3 CD86 CTLA4 CXCL10 IFNG IL10 IL4
3 immune system MP:0005387 10.29 CD86 CTLA4 CXCL10 IFNG IL10 IL4
4 cellular MP:0005384 10.27 CD86 CXCL10 IFNG IL10 IL4 IL6
5 digestive/alimentary MP:0005381 10.27 CTLA4 IFNG IL10 IL4 IL5 IL6
6 behavior/neurological MP:0005386 10.24 CD86 IFNG IL10 IL5 IL6 MYD88
7 cardiovascular system MP:0005385 10.24 CTLA4 CXCL10 IFNG IL10 IL6 MYD88
8 endocrine/exocrine gland MP:0005379 10.21 CD86 CTLA4 IFNG IL10 IL4 IL6
9 growth/size/body region MP:0005378 10.2 IFNG IL10 IL4 IL5 IL6 MYD88
10 mortality/aging MP:0010768 10.16 CTLA4 CXCL10 IFNG IL10 IL4 IL6
11 liver/biliary system MP:0005370 10.13 CTLA4 IFNG IL10 IL4 IL5 IL6
12 integument MP:0010771 10.1 CTLA4 IFNG IL10 IL4 IL6 TLR2
13 nervous system MP:0003631 10.07 CD86 CXCL10 IFNG IL10 IL4 IL6
14 neoplasm MP:0002006 10.01 IFNG IL10 IL5 IL6 MYD88 TLR2
15 muscle MP:0005369 9.98 CD86 IFNG IL10 IL6 TLR2 TLR4
16 reproductive system MP:0005389 9.86 IFNG IL10 IL4 IL5 IL6 MYD88
17 respiratory system MP:0005388 9.85 CTLA4 IFNG IL10 IL4 IL5 IL6
18 renal/urinary system MP:0005367 9.8 IFNG IL4 IL6 MYD88 TLR2 TLR4
19 skeleton MP:0005390 9.61 CTLA4 IFNG IL10 IL4 IL6 MYD88
20 vision/eye MP:0005391 9.17 IFNG IL10 IL4 IL6 MYD88 TLR4

Drugs & Therapeutics for Paracoccidioidomycosis

Search Clinical Trials , NIH Clinical Center for Paracoccidioidomycosis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: paracoccidioidomycosis

Genetic Tests for Paracoccidioidomycosis

Anatomical Context for Paracoccidioidomycosis

MalaCards organs/tissues related to Paracoccidioidomycosis:

42
Bone, Skin, Lung, Lymph Node, Testes, T Cells, Monocytes

The Foundational Model of Anatomy Ontology organs/tissues related to Paracoccidioidomycosis:

20
Skin Or, Bone, Mucosa, Lymph Nodes

Publications for Paracoccidioidomycosis

Articles related to Paracoccidioidomycosis:

(show top 50) (show all 913)
# Title Authors Year
1
DC-SIGN and VDR polymorphisms are associated with chronic form of paracoccidioidomycosis with oral manifestations. ( 30367528 )
2019
2
Oral Biopsy for Early Diagnosis of Paracoccidioidomycosis. ( 30656601 )
2019
3
New 4-methoxy-naphthalene derivatives as promisor antifungal agents for paracoccidioidomycosis treatment. ( 30663901 )
2019
4
Paracoccidioidomycosis in the external ear. ( 30868065 )
2019
5
Clinical and microbiological characteristics of paracoccidioidomycosis in patients with AIDS in Buenos Aires, Argentina. ( 30874811 )
2019
6
Pulmonary paracoccidioidomycosis associated with the use of natalizumab in multiple sclerosis. ( 29649930 )
2018
7
Intestinal paracoccidioidomycosis resembling Crohn's disease in a teenager: a case report. ( 29706133 )
2018
8
Case Report: Misleading Serological Diagnosis of Paracoccidioidomycosis in a Young Patient with the Acute Form Disease:<i>Paracoccidioides brasiliensis</i>or<i>Paracoccidioides lutzii</i>? ( 29405111 )
2018
9
67Ga Scintigraphy for Assessment of Disease Severity and Treatment Response in Patients With Paracoccidioidomycosis. ( 29517539 )
2018
10
Paracoccidioidomycosis due to Paracoccidioides brasiliensis S1 plus HIV co-infection. ( 29412355 )
2018
11
Diagnosis and Treatment of Paracoccidioidomycosis in the Maxillofacial Region: A Report of 5 Cases. ( 29850333 )
2018
12
Paracoccidioidomycosis diagnosed in bone marrow biopsy: indicative of fungemia and unfavorable prognois. ( 29944929 )
2018
13
Paracoccidioidomycosis simulating Crohn's disease. ( 29746902 )
2018
14
Unusual Intestinal Involvement by Paracoccidioidomycosis Diagnosed After Oral Manifestation. ( 29453699 )
2018
15
Paracoccidioidomycosis: Detection of Paracoccidioides brasiliensisA' genome in biological samples by quantitative chain reaction polymerase (qPCR). ( 29803846 )
2018
16
Geographical evaluation of Neuroparacoccidioidomycosis and Paracoccidioidomycosis in Southern Brazil. ( 29663530 )
2018
17
Scrotal swelling in a farmworker with paracoccidioidomycosis. ( 29551333 )
2018
18
Emergence of acute/subacute infant-juvenile paracoccidioidomycosis in Northeast Argentina: Effect of climatic and anthropogenic changes? ( 29346653 )
2018
19
A case of paracoccidioidomycosis due to<i>Paracoccidioides lutzii</i>presenting sarcoid-like form. ( 29159027 )
2018
20
Imaging paracoccidioidomycosis: A pictorial review from head to toe. ( 29685479 )
2018
21
Sarcoid-Like Paracoccidioidomycosis in a Female Urban Dweller: Reviewing a Rare Clinical Condition in Brazil. ( 29737451 )
2018
22
Estrogen Receptor-I+ Correlates with Higher Fungal Cell Number in Oral Paracoccidioidomycosis in Women. ( 29796757 )
2018
23
A multicentre study of oral paracoccidioidomycosis: analysis of 320 cases and literature review. ( 29949225 )
2018
24
Disseminated paracoccidioidomycosis prediagnosticated as neoplasm: An important challenge in diagnosis using rt-PCR. ( 29071205 )
2018
25
Pulmonary paracoccidioidomycosis: a case report of reactivation in a patient receiving biological therapy. ( 29768566 )
2018
26
Potential of the association of dodecyl gallate with nanostructured lipid system as a treatment for paracoccidioidomycosis: In vitro and in vivo efficacy and toxicity. ( 29883792 )
2018
27
67Ga Scintigraphy for Assessment of Disease Severity and Treatment Response in Patients With Paracoccidioidomycosis: Erratum. ( 29688954 )
2018
28
Notch Signaling is Required for Dendritic Cell Maturation and T Cell Expansion in Paracoccidioidomycosis. ( 29911286 )
2018
29
Chronic Multifocal Paracoccidioidomycosis: Pulmonary and Cutaneous Involvement. ( 29793811 )
2018
30
Differentiation of mucosal lesions in mucocutaneous leishmaniasis and paracoccidioidomycosis. ( 30475920 )
2018
31
Acute paracoccidioidomycosis with duodenal and cutaneous involvement and obstructive jaundice. ( 30148057 )
2018
32
Combination of Histopathology and FT-Raman Spectroscopy for the Study of Experimental Paracoccidioidomycosis in the Spleen. ( 28881447 )
2018
33
Differential production of interleukin-1 family cytokines (IL-1β, IL-18, IL-33 and IL-37) in patients with paracoccidioidomycosis: correlation with clinical form and antifungal therapy. ( 28992214 )
2018
34
Systemic paracoccidioidomycosis involving breast. ( 30033640 )
2018
35
Regulatory T cells in paracoccidioidomycosis. ( 30067137 )
2018
36
Computer-aided identification of novel anti-paracoccidioidomycosis compounds. ( 30311802 )
2018
37
Ceruloplasmin, transferrin and apolipoprotein A-II play important role in treatment's follow-up of paracoccidioidomycosis patients. ( 30359420 )
2018
38
Depletion of regulatory T cells in ongoing paracoccidioidomycosis rescues protective Th1/Th17 immunity and prevents fatal disease outcome. ( 30410119 )
2018
39
Paracoccidioidomycosis: characterization of subpopulations of macrophages and cytokines in human mucosal lesions. ( 30418569 )
2018
40
Paracoccidioidomycosis manifested by sarcoidosis-like cutaneous lesions and caused by Paracoccidioides brasiliensis sensu stricto (S1a). ( 30484542 )
2018
41
Paracoccidioidomycosis in Immunocompromised Patients: A Literature Review. ( 30587784 )
2018
42
Biliary Paracoccidioidomycosis: An Unusual Infection Simulating Malignant Neoplasm. ( 30596620 )
2018
43
Itraconazole in combination with neutrophil depletion reduces the expression of genes related to pulmonary fibrosis in an experimental model of paracoccidioidomycosis. ( 29420794 )
2017
44
Th1-Inducing Agents in Prophylaxis and Therapy for Paracoccidioidomycosis. ( 28584990 )
2017
45
Acute Paracoccidioidomycosis in a 40-Year-Old Man: A Case Report and Literature Review. ( 28900882 )
2017
46
Paracoccidioidomycosis: level of pulmonary sequelae in high resolution computed tomography images from patients of two endemic regions of Brazil. ( 28811998 )
2017
47
Therapeutic treatment with scFv-PLGA nanoparticles decreases pulmonary fungal load in a murine model of paracoccidioidomycosis. ( 28951317 )
2017
48
Bone marrow-derived mesenchymal stem cells transplantation alters the course of experimental paracoccidioidomycosis by exacerbating the chronic pulmonary inflammatory response. ( 29253200 )
2017
49
Paracoccidioidomycosis with sarcoid-like lesions:a diagnostic challenge. ( 28562770 )
2017
50
DNAhsp65 Vaccine as Therapy against Paracoccidioidomycosis. ( 28584985 )
2017

Variations for Paracoccidioidomycosis

Expression for Paracoccidioidomycosis

Search GEO for disease gene expression data for Paracoccidioidomycosis.

Pathways for Paracoccidioidomycosis

Pathways related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 CD209 CD86 CTLA4 CXCL10 IFNG IL10
2
Show member pathways
13.67 CXCL10 IFNG IL10 IL4 IL5 IL6
3
Show member pathways
13.46 CXCL10 IL10 IL4 IL5 IL6 MYD88
4
Show member pathways
13.42 CD86 CXCL10 IFNG IL10 IL4 IL5
5
Show member pathways
13.41 CD209 CD86 CTLA4 MYD88 TLR2 TLR4
6
Show member pathways
13.28 CXCL10 IL10 IL4 IL5 IL6 TNF
7
Show member pathways
13.26 CD86 CXCL10 IFNG IL10 IL6 MYD88
8
Show member pathways
13.2 IFNG IL4 MYD88 TLR2 TLR4 TNF
9
Show member pathways
12.99 CD86 IL6 MYD88 TLR2 TLR4 TNF
10
Show member pathways
12.97 IL4 IL6 TLR2 TLR4 TNF
11
Show member pathways
12.96 CD86 CTLA4 IFNG IL10 IL4 IL5
12
Show member pathways
12.83 CXCL10 IFNG IL6 MYD88 TLR4 TNF
13
Show member pathways
12.73 IL6 MYD88 TLR2 TLR4 TNF
14
Show member pathways
12.67 CD86 IFNG IL10 IL4 TNF
15 12.63 CTLA4 CXCL10 IFNG IL10 IL4 MYD88
16
Show member pathways
12.63 CD209 CXCL10 IFNG IL4 IL6 MYD88
17
Show member pathways
12.6 CD86 IFNG IL10 IL4 IL5 IL6
18
Show member pathways
12.58 MYD88 TLR2 TLR4 TNF
19
Show member pathways
12.58 IFNG IL10 IL6 TNF
20
Show member pathways
12.54 CTLA4 IFNG IL10 IL4 IL5 IL6
21
Show member pathways
12.47 IFNG IL10 IL4 IL5 IL6
22
Show member pathways
12.43 CXCL10 IFNG IL4 IL5 IL6 TLR2
23
Show member pathways
12.39 IFNG IL6 MYD88 TLR4 TNF
24
Show member pathways
12.36 IFNG IL4 IL6 TNF
25
Show member pathways
12.36 IL6 MYD88 TLR2 TLR4 TNF
26
Show member pathways
12.36 IFNG IL10 IL4 IL5 IL6 TNF
27
Show member pathways
12.34 IFNG IL10 IL4 MYD88 TLR2 TLR4
28
Show member pathways
12.31 CD209 IL10 IL6 MYD88 TNF
29 12.29 IFNG IL6 TLR2 TLR4 TNF
30
Show member pathways
12.26 IL6 MYD88 TLR2 TNF
31 12.22 CD209 IFNG IL10 IL6 MYD88 TLR2
32
Show member pathways
12.18 IFNG IL4 IL6 TLR2 TLR4 TNF
33 12.15 CXCL10 IFNG IL4 IL6 TLR4 TNF
34
Show member pathways
12.14 CD86 IFNG IL10 IL6 TLR2 TLR4
35
Show member pathways
12.14 CXCL10 IFNG IL4 IL6 MYD88 TLR2
36
Show member pathways
12.12 IFNG IL10 IL4 IL5 IL6
37 12.11 CD209 TLR2 TLR4
38 12.07 IL10 IL4 IL6 TNF
39
Show member pathways
12.02 IL5 TLR2 TLR4
40 12.01 IFNG IL10 IL6 TLR2 TLR4 TNF
41 11.99 IL4 IL5 IL6 TNF
42 11.96 CXCL10 IL6 TNF
43 11.95 IFNG IL10 IL4 IL5 TNF
44 11.94 CD86 CTLA4 IFNG IL6 TLR2 TLR4
45 11.93 IFNG IL6 MYD88 TLR4
46 11.92 IFNG IL6 TLR4
47
Show member pathways
11.92 CTLA4 IFNG IL4 IL5 TNF
48 11.92 IL10 IL6 MYD88 TLR4 TNF
49 11.91 IFNG IL4 IL5 IL6
50 11.9 CD209 IFNG IL10 IL6 TNF

GO Terms for Paracoccidioidomycosis

Cellular components related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 CXCL10 IFNG IL10 IL4 IL5 IL6
2 extracellular region GO:0005576 9.56 CD209 CXCL10 IFNG IL10 IL4 IL5
3 cell surface GO:0009986 9.55 CD209 CD86 TLR2 TLR4 TNF
4 external side of plasma membrane GO:0009897 9.1 CD209 CD86 CTLA4 CXCL10 TLR4 TNF

Biological processes related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.98 CXCL10 IFNG IL10 IL4 IL5 IL6
2 positive regulation of gene expression GO:0010628 9.95 IFNG IL4 IL6 MYD88 TLR2 TLR4
3 response to lipopolysaccharide GO:0032496 9.92 CXCL10 IL10 MYD88 TLR2 TLR4
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.91 IL6 MYD88 TLR2 TLR4 TNF
5 positive regulation of JNK cascade GO:0046330 9.89 MYD88 TLR4 TNF
6 positive regulation of inflammatory response GO:0050729 9.89 TLR2 TLR4 TNF
7 positive regulation of DNA-binding transcription factor activity GO:0051091 9.88 IL10 IL5 IL6 TNF
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.87 IFNG IL4 IL6
9 regulation of inflammatory response GO:0050727 9.87 MYD88 TLR4 TNF
10 response to virus GO:0009615 9.87 CXCL10 IFNG MYD88 TNF
11 response to glucocorticoid GO:0051384 9.86 IL10 IL6 TNF
12 defense response to Gram-positive bacterium GO:0050830 9.86 IL6 MYD88 TLR2 TNF
13 humoral immune response GO:0006959 9.85 IFNG IL6 TNF
14 positive regulation of smooth muscle cell proliferation GO:0048661 9.85 IL6 MYD88 TNF
15 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.85 TLR2 TLR4 TNF
16 positive regulation of tumor necrosis factor production GO:0032760 9.84 MYD88 TLR2 TLR4
17 positive regulation of T cell proliferation GO:0042102 9.84 CD209 CD86 IL4 IL6
18 positive regulation of nitric oxide biosynthetic process GO:0045429 9.83 IFNG TLR4 TNF
19 negative regulation of T cell proliferation GO:0042130 9.83 CD86 CTLA4 IL10
20 positive regulation of B cell proliferation GO:0030890 9.81 IL4 IL5 TLR4
21 toll-like receptor signaling pathway GO:0002224 9.81 MYD88 TLR2 TLR4
22 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.8 MYD88 TLR2 TLR4
23 cellular response to lipopolysaccharide GO:0071222 9.8 CD86 CXCL10 IL10 IL6 TLR4 TNF
24 negative regulation of interleukin-6 production GO:0032715 9.78 IL10 TLR4 TNF
25 lipopolysaccharide-mediated signaling pathway GO:0031663 9.78 MYD88 TLR2 TLR4 TNF
26 positive regulation of interleukin-12 production GO:0032735 9.77 IFNG TLR2 TLR4
27 positive regulation of interleukin-8 production GO:0032757 9.76 MYD88 TLR2 TLR4 TNF
28 inflammatory response GO:0006954 9.76 CXCL10 IL10 IL5 IL6 MYD88 TLR2
29 positive regulation of osteoclast differentiation GO:0045672 9.75 IFNG TNF
30 microglial cell activation GO:0001774 9.75 TLR2 TNF
31 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.75 MYD88 TLR4
32 positive regulation of glial cell proliferation GO:0060252 9.74 IL6 TNF
33 positive regulation of macrophage activation GO:0043032 9.74 IL10 TLR4
34 negative regulation of B cell proliferation GO:0030889 9.74 CTLA4 IL10
35 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.74 IFNG TNF
36 regulation of regulatory T cell differentiation GO:0045589 9.74 CTLA4 IFNG
37 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.74 IL10 TNF
38 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.74 TLR2 TLR4
39 regulation of cytokine secretion GO:0050707 9.73 TLR2 TLR4
40 I-kappaB phosphorylation GO:0007252 9.73 TLR2 TLR4
41 negative regulation of interleukin-17 production GO:0032700 9.73 IFNG TLR4
42 positive regulation of immunoglobulin secretion GO:0051024 9.73 IL5 IL6
43 positive regulation of podosome assembly GO:0071803 9.73 IL5 TNF
44 response to molecule of bacterial origin GO:0002237 9.73 IL10 TLR2
45 cellular response to lipoteichoic acid GO:0071223 9.72 TLR2 TLR4
46 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.72 TLR4 TNF
47 negative regulation of lipid storage GO:0010888 9.72 IL6 TNF
48 negative regulation of growth of symbiont in host GO:0044130 9.72 IL10 MYD88 TNF
49 positive regulation of lymphocyte proliferation GO:0050671 9.71 MYD88 TLR4
50 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.71 MYD88 TLR4

Molecular functions related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.97 CD209 CD86 CTLA4 CXCL10 IFNG IL10
2 Toll-like receptor binding GO:0035325 9.32 MYD88 TLR2
3 lipopolysaccharide receptor activity GO:0001875 9.26 TLR2 TLR4
4 growth factor activity GO:0008083 9.26 IL10 IL4 IL5 IL6
5 cytokine activity GO:0005125 9.17 CXCL10 IFNG IL10 IL4 IL5 IL6

Sources for Paracoccidioidomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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