PCM
MCID: PRC002
MIFTS: 53

Paracoccidioidomycosis (PCM)

Categories: Bone diseases, Immune diseases, Infectious diseases, Rare diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Paracoccidioidomycosis

MalaCards integrated aliases for Paracoccidioidomycosis:

Name: Paracoccidioidomycosis 12 73 20 58 54 44 15 17 70 32
Mucocutaneous-Lymphangitic Paracoccidioidomycosis 12
Lutz-Splendore-Almeida Disease 20
South American Blastomycosis 20
Paracoccidioidal Granuloma 20
Paracoccidioidal Mycosis 12
Lobo Disease 20
Lobomycosis 70
Pcm 20

Characteristics:

Orphanet epidemiological data:

58
paracoccidioidomycosis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:12662
ICD9CM 34 116.1
MeSH 44 D010229
NCIt 50 C34891
SNOMED-CT 67 59925007
ICD10 32 B41 B41.9
MESH via Orphanet 45 D010229
ICD10 via Orphanet 33 B41.0 B41.7 B41.8 more
UMLS via Orphanet 71 C0030409
Orphanet 58 ORPHA73260
UMLS 70 C0030409 C0152066

Summaries for Paracoccidioidomycosis

Disease Ontology : 12 A primary systemic mycosis that results in systemic fungal infection located in mucosa, located in lymph nodes, located in bone, located in skin or located in lungs, has material basis in Paracoccidioides brasiliensis.

MalaCards based summary : Paracoccidioidomycosis, also known as mucocutaneous-lymphangitic paracoccidioidomycosis, is related to histoplasmosis and cryptococcosis. An important gene associated with Paracoccidioidomycosis is IL10 (Interleukin 10), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include mucosa, lymph nodes and bone, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : 73 Paracoccidioidomycosis (PCM) is an acute to chronic fungal infection caused by fungi in the genus... more...

Related Diseases for Paracoccidioidomycosis

Diseases related to Paracoccidioidomycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 856)
# Related Disease Score Top Affiliating Genes
1 histoplasmosis 31.1 TNF IL12RB1 IFNG
2 cryptococcosis 30.7 TNF IL4 IL10 IFNG
3 nocardiosis 30.7 TNF IL12RB1 IFNG
4 tuberculous meningitis 30.2 TNF TLR2 CXCL8
5 strongyloidiasis 30.0 IL5 IL4 IFNG
6 systemic scleroderma 30.0 TNF IL6 IL4 IL10 IFNG
7 hypopyon 29.9 TNF IL6 IL10
8 radiculopathy 29.9 IL6 IL5 IL10 CXCL9 CXCL8
9 anthracosis 29.9 TNF IL6 CXCL8
10 hypereosinophilic syndrome 29.9 IL5 IL4 IL2 IL10 IFNG CXCL8
11 skin sarcoidosis 29.8 TNF IL2 IFNG CTLA4
12 spinal cord injury 29.8 TNF IL6 CXCL8
13 blepharitis 29.8 TNF IL4 CXCL8
14 oral tuberculosis 29.8 TNF IL2 IFNG
15 haemophilus influenzae 29.7 TNF TLR2 CXCL8
16 tuberculoid leprosy 29.7 TNF TLR2 IL2 IL10 IFNG
17 hepatitis c 29.7 TNF IL10 IFNG CXCL10
18 adult respiratory distress syndrome 29.7 TNF IL6 IL10 CXCL8
19 neuromyelitis optica 29.6 IL6 IL5 IL4 CXCL10
20 silicosis 29.6 TNF TLR4 IL4 IL10 CXCL8
21 gastric ulcer 29.6 TNF IL6 CXCL8
22 pneumoconiosis 29.6 TNF IL6 IL4 IL10 CXCL8
23 actinomycosis 29.6 TNF IL6 IL4 IL10 ALB
24 erysipelas 29.6 TNF IL6 IL2
25 myelitis 29.6 TNF IL6 IL10 CXCL8
26 varicose veins 29.5 TNF IL6 CXCL8
27 acquired immunodeficiency syndrome 29.5 TNF IL6 IL2 IL10 IFNG ALB
28 lupus erythematosus 29.5 TNF IL10 IFNG CTLA4 CD86 CD28
29 sarcoidosis 1 29.5 TNF IL2 IL12RB1 IFNG CXCL9 CXCL10
30 bone sarcoma 29.5 IL6 IL10 CXCL8 CTLA4
31 mucocutaneous leishmaniasis 29.5 TNF IL5 IL4 IL2 IL10 IFNG
32 rosacea 29.4 TNF TLR2 IL6 CXCL8
33 portal hypertension 29.4 TNF TLR4 CXCL8 ALB
34 intermittent claudication 29.4 IL6 IL10 ALB
35 intestinal obstruction 29.3 TNF IL6 ALB
36 miliary tuberculosis 29.3 TNF IL12RB1 IFNG ALB
37 meningoencephalitis 29.3 TNF IL6 IL10 CXCL10 ALB
38 chorioretinitis 29.3 TNF IL6 IL2 IL10 IFNG
39 osteomyelitis 29.2 TNF TLR4 TLR2 IL6 IL4 IL10
40 pulmonary emphysema 29.2 IFNG CXCL8 ALB
41 retinal detachment 29.2 TNF IL6 IL10 IFNG CXCL8 CXCL10
42 syphilis 29.1 TNF IL6 IFNG CD209 ALB
43 spondyloarthropathy 29.1 TNF IL6 IL4 IL2 IL10 IFNG
44 invasive aspergillosis 29.1 TLR4 TLR2 IL10 IFNG CXCL8 CXCL10
45 focal segmental glomerulosclerosis 29.1 TNF TLR4 IL6 IL10 ALB
46 bronchiolitis obliterans 29.1 TNF TLR4 IL6 IL10 IFNG CXCL8
47 leishmaniasis 29.1 TNF TLR4 TLR2 IL6 IL5 IL4
48 posterior uveitis 29.0 TNF IL6 IL5 IL4 IL2 IFNG
49 extrinsic allergic alveolitis 29.0 IL6 IL10 CXCL8 ALB
50 myositis 29.0 TNF IL6 IL2 IFNG CXCL8

Graphical network of the top 20 diseases related to Paracoccidioidomycosis:



Diseases related to Paracoccidioidomycosis

Symptoms & Phenotypes for Paracoccidioidomycosis

MGI Mouse Phenotypes related to Paracoccidioidomycosis:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.39 ALB CD209 CD28 CD86 CTLA4 CXCL10
2 hematopoietic system MP:0005397 10.38 CD209 CD28 CD86 CTLA4 CXCL10 IFNG
3 cellular MP:0005384 10.34 ALB CD28 CD86 CXCL10 IFNG IL10
4 immune system MP:0005387 10.34 ALB CD28 CD86 CTLA4 CXCL10 IFNG
5 digestive/alimentary MP:0005381 10.32 ALB CD28 CTLA4 IFNG IL10 IL2
6 cardiovascular system MP:0005385 10.28 ALB CTLA4 CXCL10 IFNG IL10 IL2
7 endocrine/exocrine gland MP:0005379 10.27 ALB CD28 CD86 CTLA4 IFNG IL10
8 liver/biliary system MP:0005370 10.15 ALB CTLA4 IFNG IL10 IL2 IL4
9 integument MP:0010771 10.1 CD28 CTLA4 IFNG IL10 IL12RB1 IL4
10 neoplasm MP:0002006 10 ALB CD28 IFNG IL10 IL2 IL5
11 muscle MP:0005369 9.92 ALB CD86 IFNG IL10 IL6 TLR2
12 respiratory system MP:0005388 9.9 CTLA4 IFNG IL10 IL2 IL4 IL5
13 skeleton MP:0005390 9.65 CTLA4 IFNG IL10 IL12RB1 IL4 IL6
14 vision/eye MP:0005391 9.28 CD28 IFNG IL10 IL2 IL4 IL6

Drugs & Therapeutics for Paracoccidioidomycosis

Search Clinical Trials , NIH Clinical Center for Paracoccidioidomycosis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Itraconazole
Ketoconazole

Cochrane evidence based reviews: paracoccidioidomycosis

Genetic Tests for Paracoccidioidomycosis

Anatomical Context for Paracoccidioidomycosis

The Foundational Model of Anatomy Ontology organs/tissues related to Paracoccidioidomycosis:

19
Mucosa, Lymph Nodes, Bone, Skin, Lungs

MalaCards organs/tissues related to Paracoccidioidomycosis:

40
Skin, Bone, T Cells, Bone Marrow, Thyroid, Kidney, Monocytes

Publications for Paracoccidioidomycosis

Articles related to Paracoccidioidomycosis:

(show top 50) (show all 2072)
# Title Authors PMID Year
1
Role of TLR2 and TLR4 in human neutrophil functions against Paracoccidioides brasiliensis. 61 54
20384861 2010
2
Altered expression of the costimulatory molecules CD80, CD86, CD152, PD-1 and ICOS on T-cells from paracoccidioidomycosis patients: lack of correlation with T-cell hyporesponsiveness. 54 61
18757242 2008
3
Serum interleukin-18 and soluble tumour necrosis factor receptor 2 are associated with disease severity in patients with paracoccidioidomycosis. 61 54
17302897 2007
4
Kinetics of IFN-gamma, TNF-alpha, IL-10 and IL-4 production by mononuclear cells stimulated with gp43 peptides, in patients cured of paracoccidioidomycosis. 54 61
17568881 2007
5
Interleukin-10 and tumor necrosis factor-alpha single nucleotide gene polymorphism frequency in paracoccidioidomycosis. 61 54
17145373 2006
6
Cytokines released from blood monocytes and expressed in mucocutaneous lesions of patients with paracoccidioidomycosis evaluated before and during trimethoprim-sulfamethoxazole treatment. 54 61
16536806 2006
7
The role of interleukin-10 in the differential expression of interleukin-12p70 and its beta2 receptor on patients with active or treated paracoccidioidomycosis and healthy infected subjects. 61 54
15596413 2005
8
Modulation of CD28 and CD86 expression in patients with paracoccidioidomycosis in different periods of treatment. 61 54
15541043 2004
9
Proteomic identification, nucleotide sequence, heterologous expression and immunological reactivity of the triosephosphate isomerase of Paracoccidioides brasiliensis. 61 54
15310465 2004
10
Fas-Fas ligand (CD95-CD95L) and cytotoxic T lymphocyte antigen-4 engagement mediate T cell unresponsiveness in patients with paracoccidioidomycosis. 61 54
12717632 2003
11
Dendritic cells and pattern of cytokines in paracoccidioidomycosis skin lesions. 61 54
12652191 2003
12
Heterologous expression, purification, and immunological reactivity of a recombinant HSP60 from Paracoccidioides brasiliensis. 54 61
11874881 2002
13
Molecular cloning, characterization and expression of the heat shock protein 60 gene from the human pathogenic fungus Paracoccidioides brasiliensis. 61 54
12054056 2001
14
High serum interleukin-10 and tumor necrosis factor alpha levels in chronic paracoccidioidomycosis. 61 54
11527826 2001
15
Imbalance of IL-2, IFN-gamma and IL-10 secretion in the immunosuppression associated with human paracoccidioidomycosis. 54 61
11237434 2001
16
Mixed and disseminated paracoccidioidomycosis after liver transplantation: Case report. 61
33717862 2021
17
Disseminated paracoccidioidomycosis in a liver transplant patient. 61
33775484 2021
18
Monocyte-Derived Dendritic Cells Can Revert In Vitro Antigen-Specific Cellular Anergy in Active Human Paracoccidioidomycosis. 61
33802081 2021
19
Scalp paracoccidioidomycosis: A rare and exuberant manifestation. 61
33769750 2021
20
Prevalence of pulmonary mycoses in smear-negative patients with suspected tuberculosis in the Brazilian Amazon. 61
33775537 2021
21
Pathogenesis and Classification of Paracocidioidomycosis: New Insights From Old Good Stuff. 61
33728354 2021
22
Paracoccidioidesbrasiliensis induces IL-32 and is controlled by IL-15/IL-32/vitamin D pathway in vitro. 61
33771629 2021
23
The impact of COVID-19 pandemic on AIDS-related mycoses and fungal neglected tropical diseases: Why should we worry? 61
33561159 2021
24
A single-centre, retrospective study of the incidence of invasive fungal infections during 85 years of autopsy service in Brazil. 61
33597620 2021
25
Oral Paracoccidioidomycosis affecting women: A systematic review. 61
33031605 2021
26
Paracoccidioidomycosis Diagnosed in Europe-A Systematic Literature Review. 61
33672212 2021
27
Paracoccidioidomycosis Protective Immunity. 61
33668671 2021
28
A New Duplex PCR-Assay for the Detection and Identification of Paracoccidioides Species. 61
33652623 2021
29
Updates in Paracoccidioides Biology and Genetic Advances in Fungus Manipulation. 61
33557381 2021
30
Zymosan enhances in vitro phagocyte function and the immune response of mice infected with Paracoccidioides brasiliensis. 61
33550415 2021
31
Transcriptomic profiling identifies novel transcripts, isomorphs, and noncoding RNAs in Paracoccidioides brasiliensis. 61
32692810 2021
32
Paracoccidioimycosis and white individuals: Susceptibility and biogeographic aspects in an important endemic area in Brazil. 61
33561154 2021
33
One Century of Study: What We Learned about Paracoccidioides and How This Pathogen Contributed to Advances in Antifungal Therapy. 61
33540749 2021
34
Chronic mucocutaneous candidiasis associated with paracoccidioidomycosis in a patient with mannose receptor deficiency: First case reported in the literature. 61
33759911 2021
35
IgG reactivity profile to Paracoccidioides spp. antigens in people with asymptomatic Paracoccidioidomycosis. 61
33258768 2021
36
Isolated cutaneous lesions in paracoccidioidomycosis: a suggestive case of acquisition through cutaneous inoculation. 61
33787742 2021
37
Involvement of bone in disseminated paracoccidioidomycosis. 61
33681928 2021
38
Paracoccidioidomycosis of the central nervous system with pulmonary involvement: typical imaging findings. 61
33394382 2021
39
Paracoccidioidomycosis due to Paracoccidioides brasiliensis S1 associated with acquired immunodeficiency syndrome: A case report. 61
33317932 2021
40
Lung CD103+ Dendritic cells of mice infected with Paracoccidioides brasiliensis contribute to Treg differentiation. 61
33359357 2021
41
In Vitro and In Vivo Effect of Peptides Derived from 14-3-3 Paracoccidioides spp. Protein. 61
33451062 2021
42
Paracoccidioides brasiliensis Isolated from Nine-Banded Armadillos (Dasypus novemcinctus) Reveal Population Structure and Admixture in the Amazon Basin. 61
33467393 2021
43
Interacting with Hemoglobin: Paracoccidioides spp. Recruits hsp30 on Its Cell Surface for Enhanced Ability to Use This Iron Source. 61
33401497 2021
44
β2 Integrin-Mediated Susceptibility to Paracoccidioides brasiliensis Experimental Infection in Mice. 61
33796477 2021
45
Gene expression of Paracoccidioides virulence factors after interaction with macrophages and fibroblasts. 61
33787770 2021
46
Diagnosis at different stages of paracoccidioidomycosis with oral manifestation: Report of two cases. 61
32855057 2020
47
Unraveling the susceptibility of paracoccidioidomycosis: Insights towards the pathogen-immune interplay and immunogenetics. 61
33039601 2020
48
Corrigendum to "Prostatic involvement in disseminated paracoccidioidomycosis: An unusual presentation mimicking malignant neoplasm" [Med. Mycol. Case Rep. 28 (2020) 46-48]. 61
33364153 2020
49
Parengyodontium album Isolated from Cutaneous Lesions of a Pacific White-Sided Dolphin (Lagenorhynchus obliquidens) During Treatment for Paracoccidioidomycosis Ceti. 61
32816250 2020
50
Imaging contribution for the diagnosis of disseminated paracoccidioidomycosis. 61
33031940 2020

Variations for Paracoccidioidomycosis

Expression for Paracoccidioidomycosis

Search GEO for disease gene expression data for Paracoccidioidomycosis.

Pathways for Paracoccidioidomycosis

Pathways related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.14 TNF TLR4 TLR2 MYD88 IL6 IL5
2
Show member pathways
13.94 TNF IL6 IL5 IL4 IL2 IL12RB1
3
Show member pathways
13.84 TNF TLR4 IL6 IL5 IL4 IL2
4
Show member pathways
13.64 TNF IL6 IL5 IL4 IL2 IL12RB1
5
Show member pathways
13.55 TNF TLR4 TLR2 MYD88 IL6 IL5
6
Show member pathways
13.53 TNF MYD88 IL6 IL5 IL4 IL2
7
Show member pathways
13.48 TNF IL6 IL5 IL4 IL2 IL12RB1
8
Show member pathways
13.37 TNF TLR4 TLR2 MYD88 IL6 IL2
9
Show member pathways
13.08 TNF TLR4 TLR2 MYD88 IL6 CXCL8
10
Show member pathways
13.07 TNF TLR4 TLR2 IL6 IL4 IL2
11
Show member pathways
13 TNF TLR4 TLR2 MYD88 IL6 IL2
12 12.99 IL6 IL5 IL4 IL2 IL12RB1 IFNG
13
Show member pathways
12.95 TNF TLR4 TLR2 MYD88 IL4 IL2
14
Show member pathways
12.95 TNF IL6 IL5 IL4 IL2 IL10
15
Show member pathways
12.87 TNF TLR4 TLR2 MYD88 IL6 CXCL8
16 12.86 TNF TLR2 MYD88 IL6 IFNG
17
Show member pathways
12.84 TNF IL4 IL2 IL12RB1 IL10 IFNG
18
Show member pathways
12.83 TNF TLR4 TLR2 MYD88 IL6 IL2
19
Show member pathways
12.77 TNF IL6 IL2 IL12RB1 IL10 IFNG
20 12.75 TNF TLR2 MYD88 IL4 IL2 IL10
21
Show member pathways
12.65 TNF MYD88 IFNG CXCL8 CXCL10
22
Show member pathways
12.63 IL6 IL5 IL4 IL2 IL12RB1 IL10
23
Show member pathways
12.6 TNF TLR4 TLR2 MYD88 IL6 CXCL8
24
Show member pathways
12.56 TNF IL6 IL2 IL10 CXCL9 CXCL8
25
Show member pathways
12.56 TNF TLR2 IL6 IL5 IL4 IFNG
26
Show member pathways
12.52 TNF IL6 IL4 IL2 IFNG ALB
27
Show member pathways
12.49 TNF TLR4 MYD88 IL6 IFNG CXCL8
28
Show member pathways
12.48 TNF IL6 IL5 IL4 IL2 IL10
29
Show member pathways
12.48 TNF TLR4 TLR2 MYD88 IL4 IL10
30 12.46 TNF TLR4 MYD88 CXCL8
31
Show member pathways
12.46 TNF TLR4 TLR2 MYD88 IL6 CXCL8
32 12.46 TNF TLR4 TLR2 MYD88 IL6 IL10
33
Show member pathways
12.45 IL2 CTLA4 CD86 CD28
34
Show member pathways
12.41 TNF MYD88 IL6 IL2 IL10 CD209
35 12.39 TNF TLR4 MYD88 IL6 CXCL8
36
Show member pathways
12.38 TNF TLR2 MYD88 IL6 CXCL8
37
Show member pathways
12.35 TNF TLR4 TLR2 MYD88 IL6 IL4
38 12.34 TNF TLR4 TLR2 IL6 IFNG
39 12.31 TNF TLR4 MYD88 IL6 IL2 IL10
40 12.27 TNF IL6 IL10 CXCL8
41
Show member pathways
12.27 TNF TLR4 TLR2 IL6 IL5 IL4
42 12.25 TNF TLR4 IL6 IL4 IL2 IFNG
43 12.17 TNF IL6 IL4 IL10 CXCL8
44 12.16 TNF TLR4 TLR2 IL6 IL10 IFNG
45
Show member pathways
12.15 TLR4 TLR2 IL5 IL2
46
Show member pathways
12.1 IL4 IL2 IL12RB1 IFNG
47
Show member pathways
12.07 TLR4 MYD88 IL6 IL12RB1 CXCL8
48 12.06 TNF TLR4 MYD88 CXCL8
49
Show member pathways
12.06 TLR4 TLR2 IL6 IL4 IL12RB1 IFNG
50 12.05 IL6 IL5 IL4 IL2 IFNG CXCL8

GO Terms for Paracoccidioidomycosis

Cellular components related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.93 TNF IL6 IL5 IL4 IL2 IL10
2 cell surface GO:0009986 9.73 TNF TLR4 TLR2 CD86 CD28 CD209
3 extracellular space GO:0005615 9.7 TNF IL6 IL5 IL4 IL2 IL10
4 protein complex involved in cell adhesion GO:0098636 9.32 CTLA4 CD28
5 external side of plasma membrane GO:0009897 9.28 TNF TLR4 IL12RB1 CXCL9 CXCL10 CTLA4

Biological processes related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.35 TLR4 TLR2 MYD88 IL6 IL5 IL4
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.26 TNF TLR4 TLR2 IL6 IL4 IL2
3 immune system process GO:0002376 10.22 TLR4 TLR2 MYD88 IL2 CTLA4 CD86
4 positive regulation of transcription, DNA-templated GO:0045893 10.21 TNF IL6 IL5 IL4 IL10 CD86
5 positive regulation of cell proliferation GO:0008284 10.18 IL6 IL5 IL4 IL2 IFNG CXCL10
6 negative regulation of apoptotic process GO:0043066 10.17 MYD88 IL6 IL4 IL2 IL10 CD28
7 adaptive immune response GO:0002250 10.15 IL2 IFNG CTLA4 CD86 CD209
8 cell surface receptor signaling pathway GO:0007166 10.1 MYD88 IFNG CXCL10 CD86 CD28
9 positive regulation of gene expression GO:0010628 10.06 TNF TLR4 TLR2 MYD88 IL6 IL4
10 response to lipopolysaccharide GO:0032496 10.05 TLR4 TLR2 MYD88 IL10 CXCL10
11 regulation of cell proliferation GO:0042127 10.04 TNF MYD88 CXCL9 CXCL10
12 defense response to virus GO:0051607 10.04 IL6 IFNG CXCL9 CXCL10
13 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.04 TNF TLR4 TLR2 MYD88 IL6
14 defense response GO:0006952 10.01 TNF CXCL9 CXCL8 CXCL10
15 response to virus GO:0009615 9.99 TNF MYD88 IFNG CXCL10
16 positive regulation of DNA-binding transcription factor activity GO:0051091 9.99 TNF IL6 IL5 IL10
17 defense response to Gram-positive bacterium GO:0050830 9.97 TNF TLR2 MYD88 IL6
18 positive regulation of inflammatory response GO:0050729 9.97 TNF TLR4 TLR2 IL2 IFNG
19 inflammatory response GO:0006954 9.97 TNF TLR4 TLR2 MYD88 IL6 IL5
20 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.96 TNF TLR4 TLR2 CD86
21 positive regulation of interferon-gamma production GO:0032729 9.96 TNF TLR4 IL2 IL12RB1
22 positive regulation of tumor necrosis factor production GO:0032760 9.96 TLR4 TLR2 MYD88 IL6 IFNG
23 positive regulation of JNK cascade GO:0046330 9.94 TNF TLR4 MYD88
24 neutrophil chemotaxis GO:0030593 9.94 CXCL9 CXCL8 CXCL10
25 humoral immune response GO:0006959 9.94 TNF IL6 IFNG CD28
26 negative regulation of tumor necrosis factor production GO:0032720 9.93 TLR4 IL4 IL10
27 regulation of insulin secretion GO:0050796 9.93 TNF IL6 IFNG
28 negative regulation of interleukin-6 production GO:0032715 9.93 TNF TLR4 IL10
29 apoptotic signaling pathway GO:0097190 9.93 TNF TLR4 CD28
30 chemokine-mediated signaling pathway GO:0070098 9.93 CXCL9 CXCL8 CXCL10
31 positive regulation of interleukin-1 beta production GO:0032731 9.93 TNF TLR4 IL6 IFNG
32 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.93 TNF IL6 IL4 IL2 IFNG
33 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.92 CXCL9 CXCL8 CXCL10
34 response to glucocorticoid GO:0051384 9.92 TNF IL6 IL10
35 positive regulation of smooth muscle cell proliferation GO:0048661 9.91 TNF MYD88 IL6
36 positive regulation of interleukin-8 production GO:0032757 9.91 TNF TLR4 TLR2 MYD88 IL6
37 positive regulation of interleukin-6 production GO:0032755 9.91 TNF TLR4 TLR2 MYD88 IL6 IFNG
38 positive regulation of cytokine production GO:0001819 9.9 TNF IL10 IFNG
39 T cell costimulation GO:0031295 9.9 CTLA4 CD86 CD28
40 positive regulation of B cell proliferation GO:0030890 9.9 TLR4 IL5 IL4 IL2
41 interleukin-12-mediated signaling pathway GO:0035722 9.89 IL12RB1 IL10 IFNG
42 toll-like receptor signaling pathway GO:0002224 9.89 TLR4 TLR2 MYD88
43 positive regulation of nitric oxide biosynthetic process GO:0045429 9.89 TNF TLR4 IFNG
44 negative regulation of T cell proliferation GO:0042130 9.89 IL10 CTLA4 CD86
45 positive regulation of JAK-STAT cascade GO:0046427 9.89 TNF IL6 IL5 IL10
46 positive regulation of interleukin-12 production GO:0032735 9.88 TLR4 TLR2 IFNG
47 lipopolysaccharide-mediated signaling pathway GO:0031663 9.88 TNF TLR4 TLR2 MYD88
48 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.87 TLR4 TLR2 MYD88
49 microglial cell activation GO:0001774 9.87 TNF TLR2 IL4 IFNG
50 positive regulation of interleukin-17 production GO:0032740 9.85 MYD88 IL6 IL2

Molecular functions related to Paracoccidioidomycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.23 TNF TLR4 TLR2 MYD88 IL6 IL5
2 chemokine activity GO:0008009 9.58 CXCL9 CXCL8 CXCL10
3 Toll-like receptor binding GO:0035325 9.43 TLR2 MYD88
4 CXCR3 chemokine receptor binding GO:0048248 9.37 CXCL9 CXCL10
5 growth factor activity GO:0008083 9.35 IL6 IL5 IL4 IL2 IL10
6 CXCR chemokine receptor binding GO:0045236 9.33 CXCL9 CXCL8 CXCL10
7 lipopolysaccharide receptor activity GO:0001875 9.32 TLR4 TLR2
8 cytokine activity GO:0005125 9.32 TNF IL6 IL5 IL4 IL2 IL10

Sources for Paracoccidioidomycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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