PGL3
MCID: PRG020
MIFTS: 39
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Paragangliomas 3 (PGL3)
Categories:
Cancer diseases, Ear diseases, Endocrine diseases, Genetic diseases, Rare diseases
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MalaCards integrated aliases for Paragangliomas 3:
Characteristics:OMIM:56
Inheritance:
autosomal dominant
Miscellaneous:
signs and symptoms depend on tumor location and activity see also pgl1 cells of origin are part of the diffuse neuroendocrine system (dnes) adult onset, wide range of age HPO:31Classifications:
MalaCards categories:
Global: Genetic diseases Rare diseases Cancer diseases Anatomical: Ear diseases Endocrine diseases |
UniProtKB/Swiss-Prot :
73
Paragangliomas 3: A neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion. Paragangliomas can develop at various body sites, including the head, neck, thorax and abdomen. Most commonly, they are located in the head and neck region, specifically at the carotid bifurcation, the jugular foramen, the vagal nerve, and in the middle ear.
MalaCards based summary : Paragangliomas 3, also known as pgl3, is related to hereditary paraganglioma-pheochromocytoma syndromes and paragangliomas 4, and has symptoms including aphonia An important gene associated with Paragangliomas 3 is SDHC (Succinate Dehydrogenase Complex Subunit C). Affiliated tissues include prostate, liver and lung, and related phenotypes are cranial nerve paralysis and hyperhidrosis |
Diseases in the Paraganglioma family:
Diseases related to Paragangliomas 3 via text searches within MalaCards or GeneCards Suite gene sharing:
Graphical network of the top 20 diseases related to Paragangliomas 3:![]() |
Human phenotypes related to Paragangliomas 3:31 (show all 16)
Symptoms via clinical synopsis from OMIM:56Clinical features from OMIM:605373UMLS symptoms related to Paragangliomas 3:aphonia MGI Mouse Phenotypes related to Paragangliomas 3:45
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MalaCards organs/tissues related to Paragangliomas 3:40
Prostate,
Liver,
Lung,
Endothelial,
Bone,
Breast,
Smooth Muscle
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Articles related to Paragangliomas 3:(show top 50) (show all 768)
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ClinVar genetic disease variations for Paragangliomas 3:6 (show top 50) (show all 217)
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Search
GEO
for disease gene expression data for Paragangliomas 3.
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