MCID: PRG008
MIFTS: 37

Paragonimiasis

Categories: Gastrointestinal diseases, Immune diseases, Infectious diseases, Liver diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Paragonimiasis

MalaCards integrated aliases for Paragonimiasis:

Name: Paragonimiasis 12 20 54 3 44 15 17 70 32
Paragonimus Westermani Infection 20
Infection by Paragonimus 12
Pulmonary Paragonimiasis 12
Lung Fluke Infection 12
Lung Fluke Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10699
ICD9CM 34 121.2
MeSH 44 D010237
NCIt 50 C84995
SNOMED-CT 67 30369007
ICD10 32 B66.4
UMLS 70 C0030424

Summaries for Paragonimiasis

CDC : 3 Paragonimus is a lung fluke (flatworm) that infects the lungs of humans after eating an infected raw or undercooked crab or crayfish. Less frequent, but more serious cases of paragonimiasis occur when the parasite travels to the central nervous system. Although rare, paragonimiasis has been acquired in the United States, with multiple cases reported from the Midwest. Once the diagnosis is made, effective treatment for paragonimiasis is available from a physician.

MalaCards based summary : Paragonimiasis, also known as paragonimus westermani infection, is related to hypereosinophilic syndrome and schistosomiasis. An important gene associated with Paragonimiasis is IL5 (Interleukin 5), and among its related pathways/superpathways are Allograft rejection and IL-17 Family Signaling Pathways. Affiliated tissues include lung, spleen and liver.

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection by flukes of the genus Paragonimus. In the acute phase, the symptoms are diarrhea, abdominal pain, fever, cough, urticaria, hepatosplenomegaly, pulmonary abnormalities, and eosinophilia. Pulmonary manifestations include cough, expectoration of discolored sputum, hemoptysis, and chest radiographic abnormalities. Various organs like brain, spleen and liver can be infected.

Wikipedia : 73 Paragonimiasis is a food-borne parasitic infection caused by the lung fluke, most commonly Paragonimus... more...

Related Diseases for Paragonimiasis

Diseases related to Paragonimiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 223)
# Related Disease Score Top Affiliating Genes
1 hypereosinophilic syndrome 30.6 RNASE3 IL5 IL13 IGHE CCL17
2 schistosomiasis 30.4 RNASE3 IL5 IL13 IGHE
3 fascioliasis 30.2 MT-CO1 CTSL
4 pneumonia 30.1 IL5 IL13 CCL17
5 bronchiolitis 30.0 RNASE3 IL5 IL13
6 eosinophilic pneumonia 29.9 RNASE3 IL5 IL13 CCL17
7 intestinal schistosomiasis 29.9 MT-CO1 IL5 IL13
8 lung disease 29.9 RNASE3 IL5 IL13 CXCR3
9 eosinophilic meningitis 29.8 IL5 IL13 IGHE
10 chronic eosinophilic pneumonia 29.8 RNASE3 IL5 CXCR3
11 urticaria 29.8 RNASE3 IL5 IL13 IGHE
12 clonorchiasis 29.7 PRSS16 MT-CO1 IGHE CTSL
13 cysticercosis 29.7 MT-CO1 IL5 IGHE CTSL
14 anisakiasis 29.6 TES RNASE3 IGHE
15 onchocerciasis 29.5 RNASE3 IL5 IL13 IGHE
16 proteasome-associated autoinflammatory syndrome 1 29.5 RNASE3 IL5 IL13 IGHE
17 echinococcosis 29.5 RNASE3 MT-CO1 IL5 CCL17
18 pulmonary disease, chronic obstructive 29.4 RNASE3 IL5 IL13 CXCR3
19 strongyloidiasis 29.3 TES MT-CO1 IL5 IL13 IGHE
20 ancylostomiasis 29.2 TES PRSS16 MT-CO1
21 sparganosis 28.9 TES PRSS16 MT-CO1 CTSL
22 toxocariasis 28.9 TES RNASE3 IL5 IL13 IGHE CTSL
23 pneumothorax 10.4
24 pulmonary tuberculosis 10.4
25 schistosoma mansoni infection, susceptibility/ 10.3
26 pemphigoid 10.3 IL5 IL13
27 pleurisy 10.3
28 acute asthma 10.3 RNASE3 IL5
29 loeffler endocarditis 10.3 RNASE3 IL5
30 cytokine deficiency 10.3 IL5 IL13
31 aztreonam allergy 10.3 IL5 IL13
32 cefaclor allergy 10.3 IL5 IL13
33 cefuroxime allergy 10.3 IL5 IL13
34 toxic oil syndrome 10.3 IL5 IGHE
35 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL5 IL13
36 chromium allergic contact dermatitis 10.3 IL5 IL13
37 ceftriaxone allergy 10.3 IL5 IL13
38 respiratory syncytial virus infectious disease 10.3 IL5 IL13
39 mansonelliasis 10.3 IL5 CCL17
40 loeffler syndrome 10.3 IL5 IL13
41 orange allergy 10.2 IL5 IL13
42 loiasis 10.2 IL5 IL13
43 mikulicz disease 10.2 IL5 IL13
44 patulous eustachian tube 10.2 RNASE3 IL5
45 eosinophilic gastritis 10.2 IL5 IL13
46 pemphigoid gestationis 10.2 RNASE3 IL5
47 trichinosis 10.2 IL5 IL13
48 endomyocardial fibrosis 10.2 RNASE3 IL5
49 vernal conjunctivitis 10.2 RNASE3 IGHE
50 nickel allergic contact dermatitis 10.2 IL5 IL13

Graphical network of the top 20 diseases related to Paragonimiasis:



Diseases related to Paragonimiasis

Symptoms & Phenotypes for Paragonimiasis

Drugs & Therapeutics for Paragonimiasis

Search Clinical Trials , NIH Clinical Center for Paragonimiasis

Cochrane evidence based reviews: paragonimiasis

Genetic Tests for Paragonimiasis

Anatomical Context for Paragonimiasis

MalaCards organs/tissues related to Paragonimiasis:

40
Lung, Spleen, Liver, Brain, Skin, Breast, Lymph Node

Publications for Paragonimiasis

Articles related to Paragonimiasis:

(show top 50) (show all 1089)
# Title Authors PMID Year
1
A possible role of TARC in antigen-specific Th2-dominant responses in patients with Paragonimiasis westermani. 61 54
15178895 2004
2
Elevated levels of thymus and activation-regulated chemokine (TARC) in pleural effusion samples from patients infested with Paragonimus westermani. 54 61
12390321 2002
3
Elevated IL-5 levels in pleural fluid of patients with paragonimiasis westermani. 54 61
11168004 2001
4
[A case of paragonimiasis westermani with a high level of interleukin 5 in bronchoalveolar lavage fluid]. 61 54
11244730 2000
5
Immunoglobulin G (IgG) subclass and IgE responses in human paragonimiases caused by three different species. 61 54
9665951 1998
6
Soluble CD23 and IL-5 levels in the serum and culture supernatants of peripheral blood mononuclear cells in a girl with cutaneous paragonimiasis: case report. 61 54
9692002 1998
7
Parasite-specific IgE and IgG levels in the serum and pleural effusion of paragonimiasis westermani patients. 54 61
1636875 1992
8
An outbreak of Paragonimus westermani infection among Cambodian technical intern trainees in Japan, exhibiting various extrapulmonary lesions. 61
33388385 2021
9
Paragonimus westermani metacercariae in two freshwater crab species in Kagoshima Prefecture, Japan, as a possible source of infection in wild boars and sika deer. 61
33473059 2021
10
Analysis of the misdiagnosis of 8 adult cases of paragonimiasis with lung masses as the main manifestation in Xishuangbanna, Yunnan. 61
33741016 2021
11
A case of paragonimiasis inducing bilateral pneumothorax with lung and liver involvement. 61
33779317 2021
12
Incidental diagnosis of paragonimiasis after histopathological examination of cholecystectomy specimen in Nepal: A case report. 61
33664951 2021
13
Endemicity of Paragonimus and paragonimiasis in Sub-Saharan Africa: A systematic review and mapping reveals stability of transmission in endemic foci for a multi-host parasite system. 61
33544705 2021
14
Abdominal paragonimiasis after consumption of wild boar meat. 61
33578009 2021
15
Characterization and localization of antigens for serodiagnosis of human paragonimiasis. 61
33415393 2021
16
Genetic differentiation of Southeast Asian Paragonimus Braun, 1899 (Digenea: Paragonimidae) and genetic variation in the Paragonimus heterotremus complex examined by nuclear DNA sequences. 61
33577999 2021
17
Spectrum of pleuropulmonary paragonimiasis: An analysis of 685 cases diagnosed over 22 years. 61
33017628 2021
18
A retrospective clinical analysis of pediatric paragonimiasis in a Chinese children's hospital from 2011 to 2019. 61
33479468 2021
19
Pleural lump after paragonimiasis treated by thoracoscopy: A case report. 61
33553406 2021
20
Paragonimus heterotremus Chen et Hsia, 1964 (Digenea: Paragonimidae): species identification based on the biological and genetic criteria, and pathology of infection. 61
33068148 2020
21
[Rare infections of the lungs not endemic in Germany]. 61
33162874 2020
22
A Case of Paragonimiasis in a Patient with Wet Cough. 61
32896236 2020
23
Pleuropulmonary Paragonimiasis with Multiple Nodules in the Pleura. 61
32350198 2020
24
Intracranial Pseudoaneurysm Caused by Cerebral Paragonimiasis in Pediatric Patients. 61
32386792 2020
25
Parasitic Infection Misdiagnosed As Bacterial Pneumonia: A Case Report. 61
32827408 2020
26
Comparative genomics and transcriptomics of 4 Paragonimus species provide insights into lung fluke parasitism and pathogenesis. 61
32687148 2020
27
Changing face of paragonimiasis. 61
33747890 2020
28
Identification of suspected paragonimiasis-endemic foci using a questionnaire and detection of Paragonimus ova using the Ziehl-Neelsen technique in Zamboanga Region, the Philippines. 61
32191613 2020
29
Pictorial Review of Thoracic Parasitic Diseases: A Radiologic Guide. 61
31978430 2020
30
First case report of paragonimiasis in a Malaysian man. 61
33612715 2020
31
Development of point-of-care testing tool using immunochromatography for rapid diagnosis of human paragonimiasis. 61
31891708 2020
32
Asymptomatic Human Paragonimiasis among the Karen People in Tak Province, Thailand: A Case Report. 61
32145728 2020
33
Molecular characterization of a Trichinella spiralis elastase-1 and its potential as a diagnostic antigen for trichinellosis. 61
32093735 2020
34
A case of group infections with Paraginimus species in Henan, Central China. 61
31351073 2020
35
Paragonimiasis: Neglected, Re-Emerging or Expanding Frontiers. Lessons from a Case Presenting in Jos, Plateau State. 61
32030717 2020
36
Diagnosis and Treatment of Hemorrhagic Cerebral Paragonimiasis: Three Case Reports and Literature Review. 61
30984986 2020
37
Paragonimiasis: A missed diagnosis from Nepal. 61
33304807 2020
38
[Features of granulomatous inflammation in helminthiasis, mycoses and human protozoal diseases in forensic medical practice]. 61
33180415 2020
39
Intraspinal Paragonimiasis in Children: MRI Findings and Suggestions for Pathogenesis. 61
31727748 2019
40
[Pulmonary paragonimiasis. Pediatric case report]. 61
31758906 2019
41
Reconsideration of Dr. Allen's Report about Hemoptysis Patients from High Prevalence of Archaeoparasitological Paragonimiasis in Korea. 61
31914516 2019
42
Simultaneous Paragonimus infection involving the breast and lung: A case report. 61
31911910 2019
43
Paragonimus and paragonimiasis in Asia: An update. 61
31295431 2019
44
First report of Paragonimus skrjabini miyazakii metacercariae in Geothelphusa dehaani (Sawagani) occurring in Iwate Prefecture, Japan. 61
31189784 2019
45
Harmful Parasitoses on the Russian Southern Far East under Climatic and Demographic Changes. 61
31571077 2019
46
Case Report: Paragonimiasis Presenting with Pericardial Tamponade. 61
31094314 2019
47
Diagnosis and surgical management of pericardial effusion due to paragonimiasis. 61
30930185 2019
48
The eggs of Paragonimiasis westermani in bronchial lavage fluid. 61
30597083 2019
49
Progress on the development of rapid diagnostic tests for foodborne neglected zoonotic helminthiases: A systematic review. 61
30946810 2019
50
[Clinical and imaging features of thirty cases of paragonimiasis westermani]. 61
31184058 2019

Variations for Paragonimiasis

Expression for Paragonimiasis

Search GEO for disease gene expression data for Paragonimiasis.

Pathways for Paragonimiasis

GO Terms for Paragonimiasis

Biological processes related to Paragonimiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemotaxis GO:0006935 9.43 RNASE3 CXCR3 CCL17
2 positive regulation of B cell proliferation GO:0030890 9.37 IL5 IL13
3 positive regulation of release of sequestered calcium ion into cytosol GO:0051281 9.32 IL13 CXCR3
4 inflammatory response GO:0006954 9.26 IL5 IL13 CXCR3 CCL17
5 positive regulation of immunoglobulin production GO:0002639 9.16 IL5 IL13
6 immune response GO:0006955 9.1 IL5 IL13 IGHE CXCR3 CTSL CCL17

Molecular functions related to Paragonimiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 IL5 IL13 CCL17

Sources for Paragonimiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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