PIV3
MCID: PRN029
MIFTS: 34

Parainfluenza Virus Type 3 (PIV3)

Categories: Immune diseases, Rare diseases

Aliases & Classifications for Parainfluenza Virus Type 3

MalaCards integrated aliases for Parainfluenza Virus Type 3:

Name: Parainfluenza Virus Type 3 53
Human Parainfluenza Virus Type 3 53
Piv3 53

Classifications:



Summaries for Parainfluenza Virus Type 3

NIH Rare Diseases : 53 Parainfluenza virus type 3 is one of a group of common viruses known as human parainfluenza viruses (HPIV) that cause a variety of respiratory illnesses. Symptoms usually develop between 2 and 7 days from the time of exposure and typically resolve in 7-10 days. Symptoms may include fever, runny nose, and cough. HPIV-3 can also cause bronchiolitis, bronchitis, and pneumonia. Infants and young children are particularly susceptible to HPIV-3 infections, though older adults and those with a weakened immune system are also at risk for complications. HPIVs are usually spread from an infected person to others through coughing, sneezing, and/or touching. There is currently no vaccine to protect against parainfluenza virus infections. Most HPIV infections resolve on their own and do not require special treatment, though medical intervention may be necessary for severe breathing problems. Most adults have antibodies against parainfluenza but can get repeat infections.

MalaCards based summary : Parainfluenza Virus Type 3, also known as human parainfluenza virus type 3, is related to respiratory syncytial virus infectious disease and newcastle disease. An important gene associated with Parainfluenza Virus Type 3 is ZNF17 (Zinc Finger Protein 17), and among its related pathways/superpathways is Ribosome biogenesis in eukaryotes. The drugs Glutamic Acid and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and t cells, and related phenotypes are Decreased vesicular stomatitis virus (VSV) infection and Decreased vesicular stomatitis virus (VSV) infection

Related Diseases for Parainfluenza Virus Type 3

Graphical network of the top 20 diseases related to Parainfluenza Virus Type 3:



Diseases related to Parainfluenza Virus Type 3

Symptoms & Phenotypes for Parainfluenza Virus Type 3

GenomeRNAi Phenotypes related to Parainfluenza Virus Type 3 according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-1 9.96 EIF3G HSPA9 NOP56 SLC9A3 UTP6
2 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-2 9.96 EIF3G HSPA9 NOP56 SLC9A3 UTP6
3 Decreased human parainfluenza virus type 3 (HPIV3) infection GR00241-A-4 9.65 EIF3G HSPA9 NOP56 SLC9A3 UTP6
4 Decreased lymphocytic choriomeningitis virus (LCMV) infection GR00241-A-3 9.46 EIF3G NOP56 SLC9A3 UTP6
5 Synthetic lethal with Ras GR00018-A-0 8.92 EIF3G HSPA9 NEU1 NOP56

Drugs & Therapeutics for Parainfluenza Virus Type 3

Drugs for Parainfluenza Virus Type 3 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glutamic Acid Approved, Nutraceutical Phase 1, Phase 2 56-86-0 33032
2 Vaccines Phase 1, Phase 2,Phase 2
3 Immunologic Factors Phase 1, Phase 2
4 Krestin Phase 1
5 Adjuvants, Immunologic Phase 1
6 Radiation-Protective Agents Phase 1
7 Antiviral Agents Phase 1
8 Anti-Bacterial Agents Phase 1
9 Antibiotics, Antitubercular Phase 1
10 Anti-Infective Agents Phase 1
11 interferons Phase 1
12 Protective Agents Phase 1
13 Interferon Inducers Phase 1

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 A Study to Evaluate the Safety, Tolerability, Immunogenicity and Vaccine-like Viral Shedding of MEDI-534, Against Respiratory Syncytial Virus (RSV) and Parainfluenza Virus Type 3 (PIV3), in Healthy 6 to <24 Month-old Children and in 2 Month-old Infants Completed NCT00686075 Phase 1, Phase 2
2 A Phase 1/2A Study to Evaluate the Safety, Immunogenicity, and Shedding of MEDI-560 in Infants 1 to < 12 Months of Age Terminated NCT00508651 Phase 1, Phase 2
3 Evaluating the Safety of and Immune Response to a Human Parainfluenza Virus Type 3 Ebola Virus Vaccine (HPIV3-EbovZ GP) in Healthy Adults Completed NCT02564575 Phase 1
4 Evaluating the Safety and Immunogenicity of a Human Parainfluenza Type 3 (HPIV3) Virus Vaccine in Infants and Children Completed NCT01254175 Phase 1
5 Safety of and Immune Response to a Cow/Human Parainfluenza Virus Vaccine (rB/HPIV3) in Healthy Infants, Children, and Adults Completed NCT00366782 Phase 1
6 Study to Evaluate the Safety of MEDI-534 Vaccine Against Respiratory Syncytial Virus (RSV) and Parainfluenza Virus Type 3 (PIV3) in Healthy Children Completed NCT00345670 Phase 1
7 Safety and Tolerability Study to Evaluate MEDI-534 in Children 6 to < 24 Months of Age Completed NCT00493285 Phase 1
8 Safety of and Immune Response to Recombinant Live Attenuated Parainfluenza Type 3 Virus Vaccine in Healthy Infants and Children Completed NCT01021397 Phase 1 rHPIV3cp45;rHPIV3cp45 placebo
9 Safety of and Immune Response to a Human Parainfluenza Virus Vaccine (rHPIV3cp45) in Healthy Infants Completed NCT00308412 Phase 1
10 Evaluating the Live-Attenuated Human Parainfluenza Virus Type 3 Vectored Vaccine Candidate Expressing Ebolavirus Zaire Glycoprotein as the Sole Envelope Glycoprotein Recruiting NCT03462004 Phase 1
11 T-Lymphocytes for Prevention or Treatment of Viral Infections Following Hematopoietic Stem Cell Transplantation Recruiting NCT03180216 Phase 1
12 Safety, Reactogenicity, and Immunogenicity of mRNA-1653 in Healthy Adults Active, not recruiting NCT03392389 Phase 1
13 Study to Evaluate MEDI-534 in Healthy Adults Completed NCT00111878 MEDI-534

Search NIH Clinical Center for Parainfluenza Virus Type 3

Genetic Tests for Parainfluenza Virus Type 3

Anatomical Context for Parainfluenza Virus Type 3

MalaCards organs/tissues related to Parainfluenza Virus Type 3:

41
Lung, Bone, T Cells, Testes, Brain, Kidney, Bone Marrow

Publications for Parainfluenza Virus Type 3

Articles related to Parainfluenza Virus Type 3:

(show top 50) (show all 311)
# Title Authors Year
1
Inclusion bodies of human parainfluenza virus type 3 inhibit antiviral stress granule formation by shielding viral RNAs. ( 29518158 )
2018
2
Analysis of microRNAs Expression Profiles in Madin-Darby Bovine Kidney Cells Infected With Caprine Parainfluenza Virus Type 3. ( 29651410 )
2018
3
Human Parainfluenza Virus Type 3 Matrix Protein Reduces Viral RNA Synthesis of HPIV3 by Regulating Inclusion Body Formation. ( 29534486 )
2018
4
An alanine residue in human parainfluenza virus type 3 phosphoprotein is critical for restricting excessive N<sup>0</sup>-P interaction and maintaining N solubility. ( 29455063 )
2018
5
Inflammasome Antagonism by Human Parainfluenza Virus Type 3 C Protein. ( 29187536 )
2018
6
Functional analysis of amino acids at stalk/head interface of human parainfluenza virus type 3 hemagglutinin-neuraminidase protein in the membrane fusion process. ( 29516315 )
2018
7
A chimeric glycoprotein formulated with a combination adjuvant induces protective immunity against both human respiratory syncytial virus and parainfluenza virus type 3. ( 30071204 )
2018
8
Cellular microRNA bta-miR-222 suppresses caprine parainfluenza virus type 3 replication via downregulation of interferon regulatory factor 2. ( 30269791 )
2018
9
Screening and Identification of ssDNA aptamers against HN protein for detection of bovine parainfluenza virus type 3 antibodies in serum. ( 30381069 )
2018
10
Maternal vaccination with a novel chimeric glycoprotein formulated with a polymer-based adjuvant provides protection from human parainfluenza virus type 3 in newborn lambs. ( 30550799 )
2018
11
Identification of candidate protein markers of Bovine Parainfluenza Virus Type 3 infection using an in vitro model. ( 28619153 )
2017
12
Inclusion Body Fusion of Human Parainfluenza Virus Type 3 Regulated by Acetylated I+-Tubulin Enhances Viral Replication. ( 27881643 )
2017
13
Human parainfluenza virus type 3 infections in hematopoietic stem cell transplantation patients: The mode of nosocomial infections and the prognosis. ( 29279454 )
2017
14
Vaccination with a human parainfluenza virus type 3 chimeric FHN glycoprotein formulated with a combination adjuvant induces protective immunity. ( 29153777 )
2017
15
Development of a blocking ELISA for Caprine parainfluenza virus type 3. ( 28966036 )
2017
16
Cholesterol-rich lipid rafts play a critical role in bovine parainfluenza virus type 3 (BPIV3) infection. ( 28654867 )
2017
17
A single L288I substitution in the fusion protein of bovine parainfluenza virus type 3 enhances virus growth in semi-suitable cell lines. ( 28451903 )
2017
18
The Matrix Protein of Human Parainfluenza Virus Type 3 Induces Mitophagy that Suppresses Interferon Responses. ( 28407488 )
2017
19
Reciprocal complementation of bovine parainfluenza virus type 3 lacking either the membrane or fusion gene. ( 28842134 )
2017
20
Parainfluenza virus type 3 outbreak in a neonatal intensive care unit. ( 29359411 )
2017
21
Complete Genome Sequences of Two Human Parainfluenza Virus Type 3 Isolates Collected in Brazil. ( 29217788 )
2017
22
Genetic analysis of human parainfluenza virus type 3 obtained in Croatia, 2011-2015. ( 28463659 )
2017
23
Exploring inhibitor structural features required to engage the 216-loop of human parainfluenza virus type-3 hemagglutinin-neuraminidase. ( 30108698 )
2017
24
Surveillance, isolation and complete genome sequence of bovine parainfluenza virus type 3 in Egyptian cattle. ( 30255042 )
2017
25
Rapid detection of novel caprine parainfluenza virus type 3 (CPIV3) using a TaqMan-based RT-qPCR. ( 27448824 )
2016
26
Pathogenicity and horizontal transmission studies of caprine parainfluenza virus type 3 JS2013 strain in goats. ( 27374058 )
2016
27
Viral Protein Requirements for Assembly and Release of Human Parainfluenza Virus Type 3 Virus-Like Particles. ( 26960133 )
2016
28
A molecular epidemiological study of human parainfluenza virus type 3 at a tertiary university hospital during 2013-2015 in Catalonia, Spain. ( 27524509 )
2016
29
Identification of Interferon-Stimulated Gene Proteins That Inhibit Human Parainfluenza Virus Type 3. ( 27707917 )
2016
30
A parainfluenza virus type 3 outbreak at a residential aged care facility: The role of microbiologic testing in early identification and antimicrobial stewardship. ( 27665033 )
2016
31
Development and evaluation of two truncated recombinant NP antigen-based indirect ELISAs for detection of bovine parainfluenza virus type 3 antibodies in cattle. ( 26031225 )
2015
32
Interaction of Human Parainfluenza Virus Type 3 Nucleoprotein with Matrix Protein Mediates Internal Viral Protein Assembly. ( 26656716 )
2015
33
The aberrant gene-end transcription signal of the matrix M gene of human parainfluenza virus type 3 downregulates fusion F protein expression and the F-specific antibody response in vivo. ( 25589643 )
2015
34
Human parainfluenza virus type 3 (HPIV3) induces production of IFNI^ and RANTES in human nasal epithelial cells (HNECs). ( 25722655 )
2015
35
Amino acid substitutions contributing to I+2,6-sialic acid linkage binding specificity of human parainfluenza virus type 3 hemagglutinin-neuraminidase. ( 25871520 )
2015
36
Identification of three antigen epitopes on the nucleocapsid protein of the genotype C of bovine parainfluenza virus type 3. ( 25960335 )
2015
37
Mutations in the DI-DII Linker of Human Parainfluenza Virus Type 3 Fusion Protein Result in Diminished Fusion Activity. ( 26305905 )
2015
38
Infection of the upper respiratory tract of hamsters by the bovine parainfluenza virus type 3 BN-1 strain expressing enhanced green fluorescent protein. ( 25543964 )
2015
39
Epidemiology and clinical outcome of lower respiratory tract infections by respiratory syncytial virus or parainfluenza virus type 3 in adults receiving treatment for either acute leukemia or severe aplastic anemia: a retrospective single center study. ( 26204825 )
2015
40
Catalytic mechanism and novel receptor binding sites of human parainfluenza virus type 3 hemagglutinin-neuraminidase (hPIV3 HN). ( 26364554 )
2015
41
Parainfluenza virus type 3 Ab in allogeneic hematopoietic cell transplant recipients: factors influencing post-transplant Ab titers and associated outcomes. ( 24978141 )
2014
42
A leucine residue in the C terminus of human parainfluenza virus type 3 matrix protein is essential for efficient virus-like particle and virion release. ( 25187547 )
2014
43
Chimeric bovine/human parainfluenza virus type 3 expressing respiratory syncytial virus (RSV) F glycoprotein: effect of insert position on expression, replication, immunogenicity, stability, and protection against RSV infection. ( 24478424 )
2014
44
Molecular evolution of the haemagglutinin-neuraminidase gene in human parainfluenza virus type 3 isolates from children with acute respiratory illness in Yamagata prefecture, Japan. ( 24464692 )
2014
45
Wheat germ cell-free system-based production of hemagglutinin-neuraminidase glycoprotein of human parainfluenza virus type 3 for generation and characterization of monoclonal antibody. ( 24860558 )
2014
46
Phosphoprotein of human parainfluenza virus type 3 blocks autophagosome-lysosome fusion to increase virus production. ( 24832451 )
2014
47
Pathogenesis of a genotype C strain of bovine parainfluenza virus type 3 infection in albino guinea pigs. ( 24681303 )
2014
48
Complete genome sequence of the first isolate of genotype C bovine parainfluenza virus type 3 in Japan. ( 25428970 )
2014
49
A novel parainfluenza virus type 3 (PIV3) identified from goat herds with respiratory diseases in eastern China. ( 25236986 )
2014
50
Seasonal patterns of respiratory syncytial virus, influenza A virus, human metapneumovirus, and parainfluenza virus type 3 infections on the basis of virus isolation data between 2004 and 2011 in Yamagata, Japan. ( 23514911 )
2013

Variations for Parainfluenza Virus Type 3

Expression for Parainfluenza Virus Type 3

Search GEO for disease gene expression data for Parainfluenza Virus Type 3.

Pathways for Parainfluenza Virus Type 3

Pathways related to Parainfluenza Virus Type 3 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.64 NOP56 UTP6

GO Terms for Parainfluenza Virus Type 3

Cellular components related to Parainfluenza Virus Type 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 small-subunit processome GO:0032040 8.62 NOP56 UTP6

Molecular functions related to Parainfluenza Virus Type 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 snoRNA binding GO:0030515 8.62 NOP56 UTP6

Sources for Parainfluenza Virus Type 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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