MCID: PRN029
MIFTS: 34

Parainfluenza Virus Type 3

Categories: Rare diseases

Aliases & Classifications for Parainfluenza Virus Type 3

MalaCards integrated aliases for Parainfluenza Virus Type 3:

Name: Parainfluenza Virus Type 3 53
Human Parainfluenza Virus Type 3 53
Piv3 53

Classifications:



Summaries for Parainfluenza Virus Type 3

NIH Rare Diseases : 53 Parainfluenza virus type 3 is one of a group of common viruses known as human parainfluenza viruses (HPIV) that cause a variety of respiratory illnesses. Symptoms usually develop between 2 and 7 days from the time of exposure and typically resolve in 7-10 days. Symptoms may include fever, runny nose, and cough. HPIV-3 can also cause bronchiolitis, bronchitis, and pneumonia. Infants and young children are particularly susceptible to HPIV-3 infections, though older adults and those with a weakened immune system are also at risk for complications. HPIVs are usually spread from an infected person to others through coughing, sneezing, and/or touching. There is currently no vaccine to protect against parainfluenza virus infections. Most HPIV infections resolve on their own and do not require special treatment, though medical intervention may be necessary for severe breathing problems. Most adults have antibodies against parainfluenza but can get repeat infections.

MalaCards based summary : Parainfluenza Virus Type 3, also known as human parainfluenza virus type 3, is related to respiratory syncytial virus infectious disease and newcastle disease. An important gene associated with Parainfluenza Virus Type 3 is ZNF17 (Zinc Finger Protein 17), and among its related pathways/superpathways is rRNA processing in the nucleus and cytosol. The drugs Glutamic Acid and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and testes, and related phenotypes are Decreased shRNA abundance and Decreased shRNA abundance

Related Diseases for Parainfluenza Virus Type 3

Graphical network of the top 20 diseases related to Parainfluenza Virus Type 3:



Diseases related to Parainfluenza Virus Type 3

Symptoms & Phenotypes for Parainfluenza Virus Type 3

GenomeRNAi Phenotypes related to Parainfluenza Virus Type 3 according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance GR00251-A-1 10.16 DCAF13 UTP6 WDR46 ARCN1
2 Decreased shRNA abundance GR00251-A-2 10.16 ARCN1 DCAF13 UTP6 WDR46
3 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-1 10.16 ARCN1 DCAF13 MAT2A UTP6 WDR46
4 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-2 10.16 WDR46 ARCN1 DCAF13 MAT2A UTP6
5 Decreased human parainfluenza virus type 3 (HPIV3) infection GR00241-A-4 9.77 ARCN1 DCAF13 MAT2A UTP6 WDR46
6 Decreased lymphocytic choriomeningitis virus (LCMV) infection GR00241-A-3 9.72 ARCN1 DCAF13 MAT2A UTP6 WDR46
7 Decreased Hepatitis C virus replication GR00180-A-1 9.71 ARCN1 WDR46
8 Decreased Hepatitis C virus replication GR00180-A-2 9.71 ARCN1 WDR46
9 Nuclear 40S maturation defects GR00209-A-2 8.96 DCAF13 WDR46
10 Nucleoplasmic pre-40S maturation defects GR00209-A-1 8.8 DCAF13 UTP6 WDR46

Drugs & Therapeutics for Parainfluenza Virus Type 3

Drugs for Parainfluenza Virus Type 3 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glutamic Acid Approved, Nutraceutical Phase 1, Phase 2 56-86-0 33032
2 Vaccines Phase 1, Phase 2,Phase 2
3 Krestin Phase 1

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 A Study to Evaluate the Safety, Tolerability, Immunogenicity and Vaccine-like Viral Shedding of MEDI-534, Against Respiratory Syncytial Virus (RSV) and Parainfluenza Virus Type 3 (PIV3), in Healthy 6 to <24 Month-old Children and in 2 Month-old Infants Completed NCT00686075 Phase 1, Phase 2
2 A Phase 1/2A Study to Evaluate the Safety, Immunogenicity, and Shedding of MEDI-560 in Infants 1 to < 12 Months of Age Terminated NCT00508651 Phase 1, Phase 2
3 Evaluating the Safety of and Immune Response to a Human Parainfluenza Virus Type 3 Ebola Virus Vaccine (HPIV3-EbovZ GP) in Healthy Adults Completed NCT02564575 Phase 1
4 Evaluating the Safety and Immunogenicity of a Human Parainfluenza Type 3 (HPIV3) Virus Vaccine in Infants and Children Completed NCT01254175 Phase 1
5 Safety of and Immune Response to a Cow/Human Parainfluenza Virus Vaccine (rB/HPIV3) in Healthy Infants, Children, and Adults Completed NCT00366782 Phase 1
6 Study to Evaluate the Safety of MEDI-534 Vaccine Against Respiratory Syncytial Virus (RSV) and Parainfluenza Virus Type 3 (PIV3) in Healthy Children Completed NCT00345670 Phase 1
7 Safety and Tolerability Study to Evaluate MEDI-534 in Children 6 to < 24 Months of Age Completed NCT00493285 Phase 1
8 Safety of and Immune Response to Recombinant Live Attenuated Parainfluenza Type 3 Virus Vaccine in Healthy Infants and Children Completed NCT01021397 Phase 1 rHPIV3cp45;rHPIV3cp45 placebo
9 Safety of and Immune Response to a Human Parainfluenza Virus Vaccine (rHPIV3cp45) in Healthy Infants Completed NCT00308412 Phase 1
10 Evaluating the Live-Attenuated Human Parainfluenza Virus Type 3 Vectored Vaccine Candidate Expressing Ebolavirus Zaire Glycoprotein as the Sole Envelope Glycoprotein Recruiting NCT03462004 Phase 1
11 Safety, Reactogenicity, and Immunogenicity of mRNA-1653 in Healthy Adults Recruiting NCT03392389 Phase 1
12 T-Lymphocytes for Prevention or Treatment of Viral Infections Following Hematopoietic Stem Cell Transplantation Recruiting NCT03180216 Phase 1
13 Study to Evaluate MEDI-534 in Healthy Adults Completed NCT00111878 MEDI-534

Search NIH Clinical Center for Parainfluenza Virus Type 3

Genetic Tests for Parainfluenza Virus Type 3

Anatomical Context for Parainfluenza Virus Type 3

MalaCards organs/tissues related to Parainfluenza Virus Type 3:

41
Lung, T Cells, Testes, Monocytes, Liver, Bone, Kidney

Publications for Parainfluenza Virus Type 3

Articles related to Parainfluenza Virus Type 3:

(show top 50) (show all 294)
# Title Authors Year
1
Inclusion bodies of human parainfluenza virus type 3 inhibit antiviral stress granule formation by shielding viral RNAs. ( 29518158 )
2018
2
Analysis of microRNAs Expression Profiles in Madin-Darby Bovine Kidney Cells Infected With Caprine Parainfluenza Virus Type 3. ( 29651410 )
2018
3
Human Parainfluenza Virus Type 3 Matrix Protein Reduces Viral RNA Synthesis of HPIV3 by Regulating Inclusion Body Formation. ( 29534486 )
2018
4
An alanine residue in human parainfluenza virus type 3 phosphoprotein is critical for restricting excessive N<sup>0</sup>-P interaction and maintaining N solubility. ( 29455063 )
2018
5
Inflammasome Antagonism by Human Parainfluenza Virus Type 3 C Protein. ( 29187536 )
2018
6
Functional analysis of amino acids at stalk/head interface of human parainfluenza virus type 3 hemagglutinin-neuraminidase protein in the membrane fusion process. ( 29516315 )
2018
7
Identification of candidate protein markers of Bovine Parainfluenza Virus Type 3 infection using an in vitro model. ( 28619153 )
2017
8
Inclusion Body Fusion of Human Parainfluenza Virus Type 3 Regulated by Acetylated I+-Tubulin Enhances Viral Replication. ( 27881643 )
2017
9
Human parainfluenza virus type 3 infections in hematopoietic stem cell transplantation patients: The mode of nosocomial infections and the prognosis. ( 29279454 )
2017
10
Vaccination with a human parainfluenza virus type 3 chimeric FHN glycoprotein formulated with a combination adjuvant induces protective immunity. ( 29153777 )
2017
11
Development of a blocking ELISA for Caprine parainfluenza virus type 3. ( 28966036 )
2017
12
Cholesterol-rich lipid rafts play a critical role in bovine parainfluenza virus type 3 (BPIV3) infection. ( 28654867 )
2017
13
A single L288I substitution in the fusion protein of bovine parainfluenza virus type 3 enhances virus growth in semi-suitable cell lines. ( 28451903 )
2017
14
The Matrix Protein of Human Parainfluenza Virus Type 3 Induces Mitophagy that Suppresses Interferon Responses. ( 28407488 )
2017
15
Reciprocal complementation of bovine parainfluenza virus type 3 lacking either the membrane or fusion gene. ( 28842134 )
2017
16
Parainfluenza virus type 3 outbreak in a neonatal intensive care unit. ( 29359411 )
2017
17
Complete Genome Sequences of Two Human Parainfluenza Virus Type 3 Isolates Collected in Brazil. ( 29217788 )
2017
18
Genetic analysis of human parainfluenza virus type 3 obtained in Croatia, 2011-2015. ( 28463659 )
2017
19
Rapid detection of novel caprine parainfluenza virus type 3 (CPIV3) using a TaqMan-based RT-qPCR. ( 27448824 )
2016
20
Pathogenicity and horizontal transmission studies of caprine parainfluenza virus type 3 JS2013 strain in goats. ( 27374058 )
2016
21
Viral Protein Requirements for Assembly and Release of Human Parainfluenza Virus Type 3 Virus-Like Particles. ( 26960133 )
2016
22
A molecular epidemiological study of human parainfluenza virus type 3 at a tertiary university hospital during 2013-2015 in Catalonia, Spain. ( 27524509 )
2016
23
Identification of Interferon-Stimulated Gene Proteins That Inhibit Human Parainfluenza Virus Type 3. ( 27707917 )
2016
24
A parainfluenza virus type 3 outbreak at a residential aged care facility: The role of microbiologic testing in early identification and antimicrobial stewardship. ( 27665033 )
2016
25
Development and evaluation of two truncated recombinant NP antigen-based indirect ELISAs for detection of bovine parainfluenza virus type 3 antibodies in cattle. ( 26031225 )
2015
26
Interaction of Human Parainfluenza Virus Type 3 Nucleoprotein with Matrix Protein Mediates Internal Viral Protein Assembly. ( 26656716 )
2015
27
The aberrant gene-end transcription signal of the matrix M gene of human parainfluenza virus type 3 downregulates fusion F protein expression and the F-specific antibody response in vivo. ( 25589643 )
2015
28
Human parainfluenza virus type 3 (HPIV3) induces production of IFNI^ and RANTES in human nasal epithelial cells (HNECs). ( 25722655 )
2015
29
Amino acid substitutions contributing to I+2,6-sialic acid linkage binding specificity of human parainfluenza virus type 3 hemagglutinin-neuraminidase. ( 25871520 )
2015
30
Identification of three antigen epitopes on the nucleocapsid protein of the genotype C of bovine parainfluenza virus type 3. ( 25960335 )
2015
31
Mutations in the DI-DII Linker of Human Parainfluenza Virus Type 3 Fusion Protein Result in Diminished Fusion Activity. ( 26305905 )
2015
32
Infection of the upper respiratory tract of hamsters by the bovine parainfluenza virus type 3 BN-1 strain expressing enhanced green fluorescent protein. ( 25543964 )
2015
33
Epidemiology and clinical outcome of lower respiratory tract infections by respiratory syncytial virus or parainfluenza virus type 3 in adults receiving treatment for either acute leukemia or severe aplastic anemia: a retrospective single center study. ( 26204825 )
2015
34
Catalytic mechanism and novel receptor binding sites of human parainfluenza virus type 3 hemagglutinin-neuraminidase (hPIV3 HN). ( 26364554 )
2015
35
Parainfluenza virus type 3 Ab in allogeneic hematopoietic cell transplant recipients: factors influencing post-transplant Ab titers and associated outcomes. ( 24978141 )
2014
36
A leucine residue in the C terminus of human parainfluenza virus type 3 matrix protein is essential for efficient virus-like particle and virion release. ( 25187547 )
2014
37
Chimeric bovine/human parainfluenza virus type 3 expressing respiratory syncytial virus (RSV) F glycoprotein: effect of insert position on expression, replication, immunogenicity, stability, and protection against RSV infection. ( 24478424 )
2014
38
Molecular evolution of the haemagglutinin-neuraminidase gene in human parainfluenza virus type 3 isolates from children with acute respiratory illness in Yamagata prefecture, Japan. ( 24464692 )
2014
39
Wheat germ cell-free system-based production of hemagglutinin-neuraminidase glycoprotein of human parainfluenza virus type 3 for generation and characterization of monoclonal antibody. ( 24860558 )
2014
40
Phosphoprotein of human parainfluenza virus type 3 blocks autophagosome-lysosome fusion to increase virus production. ( 24832451 )
2014
41
Pathogenesis of a genotype C strain of bovine parainfluenza virus type 3 infection in albino guinea pigs. ( 24681303 )
2014
42
Complete genome sequence of the first isolate of genotype C bovine parainfluenza virus type 3 in Japan. ( 25428970 )
2014
43
A novel parainfluenza virus type 3 (PIV3) identified from goat herds with respiratory diseases in eastern China. ( 25236986 )
2014
44
Seasonal patterns of respiratory syncytial virus, influenza A virus, human metapneumovirus, and parainfluenza virus type 3 infections on the basis of virus isolation data between 2004 and 2011 in Yamagata, Japan. ( 23514911 )
2013
45
Antiviral activity of mycosynthesized silver nanoparticles against herpes simplex virus and human parainfluenza virus type 3. ( 24235828 )
2013
46
Human parainfluenza virus type 3 in wild nonhuman primates, Zambia. ( 23968816 )
2013
47
Role of N-linked glycosylation of the human parainfluenza virus type 3 hemagglutinin-neuraminidase protein. ( 23562646 )
2013
48
Complete Genome Sequences of Bovine Parainfluenza Virus Type 3 Strain BN-1 and Vaccine Strain BN-CE. ( 23469358 )
2013
49
Influence of antigen insertion site and vector dose on immunogenicity and protective capacity in Sendai virus-based human parainfluenza virus type 3 vaccines. ( 23514887 )
2013
50
Molecular characterization of a Korean bovine parainfluenza virus type 3 isolate. ( 23140940 )
2013

Variations for Parainfluenza Virus Type 3

Expression for Parainfluenza Virus Type 3

Search GEO for disease gene expression data for Parainfluenza Virus Type 3.

Pathways for Parainfluenza Virus Type 3

Pathways related to Parainfluenza Virus Type 3 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.61 DCAF13 UTP6 WDR46

GO Terms for Parainfluenza Virus Type 3

Cellular components related to Parainfluenza Virus Type 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 small-subunit processome GO:0032040 8.8 DCAF13 UTP6 WDR46

Biological processes related to Parainfluenza Virus Type 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 rRNA processing GO:0006364 9.13 DCAF13 UTP6 WDR46
2 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000462 8.8 DCAF13 UTP6 WDR46

Sources for Parainfluenza Virus Type 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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