MCID: PRN029
MIFTS: 31

Parainfluenza Virus Type 3

Categories: Immune diseases, Rare diseases

Aliases & Classifications for Parainfluenza Virus Type 3

MalaCards integrated aliases for Parainfluenza Virus Type 3:

Name: Parainfluenza Virus Type 3 54
Human Parainfluenza Virus Type 3 54
Piv3 54

Classifications:



Summaries for Parainfluenza Virus Type 3

NIH Rare Diseases : 54 Parainfluenza virus type 3 is one of a group of common viruses known as human parainfluenza viruses (HPIV) that cause a variety of respiratory illnesses. Symptoms usually develop between 2 and 7 days from the time of exposure and typically resolve in 7-10 days. Symptoms may include fever, runny nose, and cough. HPIV-3 can also cause bronchiolitis, bronchitis, and pneumonia. Infants and young children are particularly susceptible to HPIV-3 infections, though older adults and those with a weakened immune system are also at risk for complications. HPIVs are usually spread from an infected person to others through coughing, sneezing, and/or touching. There is currently no vaccine to protect against parainfluenza virus infections. Most HPIV infections resolve on their own and do not require special treatment, though medical intervention may be necessary for severe breathing problems. Most adults have antibodies against parainfluenza but can get repeat infections.

MalaCards based summary : Parainfluenza Virus Type 3, also known as human parainfluenza virus type 3, is related to respiratory syncytial virus infectious disease and newcastle disease. An important gene associated with Parainfluenza Virus Type 3 is ZNF17 (Zinc Finger Protein 17). The drugs Glutamic Acid and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and t cells, and related phenotypes are Decreased vesicular stomatitis virus (VSV) infection and Decreased vesicular stomatitis virus (VSV) infection

Related Diseases for Parainfluenza Virus Type 3

Graphical network of the top 20 diseases related to Parainfluenza Virus Type 3:



Diseases related to Parainfluenza Virus Type 3

Symptoms & Phenotypes for Parainfluenza Virus Type 3

GenomeRNAi Phenotypes related to Parainfluenza Virus Type 3 according to GeneCards Suite gene sharing:

27 (show all 23)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-1 10.16 HSPA9 MAT2A NOP56 PPP1R15B SLC9A3
2 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-2 10.16 HSPA9 MAT2A NOP56 PPP1R15B SLC9A3
3 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.91 HSPA9
4 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.91 PPP1R15B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.91 HSPA9
6 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.91 PPP1R15B
7 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.91 PPP1R15B
8 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.91 HSPA9
9 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.91 PPP1R15B
10 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.91 HSPA9
11 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.91 HSPA9
12 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.91 HSPA9
13 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.91 HSPA9
14 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.91 HSPA9
15 Increased shRNA abundance (Z-score > 2) GR00366-A-24 9.91 HSPA9
16 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.91 HSPA9
17 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.91 PPP1R15B
18 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.91 PPP1R15B
19 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.91 HSPA9 PPP1R15B
20 Decreased human parainfluenza virus type 3 (HPIV3) infection GR00241-A-4 9.77 HSPA9 MAT2A NOP56 PPP1R15B SLC9A3
21 Decreased ionizing radiation sensitivity GR00232-A-1 9.72 HSPA9 MAT2A NEU1 PPP1R15B SLC9A3
22 Decreased lymphocytic choriomeningitis virus (LCMV) infection GR00241-A-3 9.56 MAT2A NOP56 PPP1R15B SLC9A3
23 Increased viability GR00386-A-1 9.17 HSPA9 IFNB1 MAT2A NEU1 NOP56 PPP1R15B

Drugs & Therapeutics for Parainfluenza Virus Type 3

Drugs for Parainfluenza Virus Type 3 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glutamic Acid Approved, Nutraceutical Phase 1, Phase 2 56-86-0 33032
2 Vaccines Phase 1, Phase 2,Phase 2
3 Immunologic Factors Phase 1, Phase 2
4 polysaccharide-K Phase 1
5 Anti-Infective Agents Phase 1
6 Radiation-Protective Agents Phase 1
7 interferons Phase 1
8 Protective Agents Phase 1
9 Anti-Bacterial Agents Phase 1
10 Antibiotics, Antitubercular Phase 1
11 Adjuvants, Immunologic Phase 1
12 Interferon Inducers Phase 1
13 Antiviral Agents Phase 1

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 A Study to Evaluate the Safety, Tolerability, Immunogenicity and Vaccine-like Viral Shedding of MEDI-534, Against Respiratory Syncytial Virus (RSV) and Parainfluenza Virus Type 3 (PIV3), in Healthy 6 to <24 Month-old Children and in 2 Month-old Infants Completed NCT00686075 Phase 1, Phase 2
2 A Phase 1/2A Study to Evaluate the Safety, Immunogenicity, and Shedding of MEDI-560 in Infants 1 to < 12 Months of Age Terminated NCT00508651 Phase 1, Phase 2
3 Evaluating the Safety of and Immune Response to a Human Parainfluenza Virus Type 3 Ebola Virus Vaccine (HPIV3-EbovZ GP) in Healthy Adults Completed NCT02564575 Phase 1
4 Evaluating the Safety and Immunogenicity of a Human Parainfluenza Type 3 (HPIV3) Virus Vaccine in Infants and Children Completed NCT01254175 Phase 1
5 Safety of and Immune Response to a Cow/Human Parainfluenza Virus Vaccine (rB/HPIV3) in Healthy Infants, Children, and Adults Completed NCT00366782 Phase 1
6 Study to Evaluate the Safety of MEDI-534 Vaccine Against Respiratory Syncytial Virus (RSV) and Parainfluenza Virus Type 3 (PIV3) in Healthy Children Completed NCT00345670 Phase 1
7 Safety and Tolerability Study to Evaluate MEDI-534 in Children 6 to < 24 Months of Age Completed NCT00493285 Phase 1
8 Safety of and Immune Response to Recombinant Live Attenuated Parainfluenza Type 3 Virus Vaccine in Healthy Infants and Children Completed NCT01021397 Phase 1 rHPIV3cp45;rHPIV3cp45 placebo
9 Safety of and Immune Response to a Human Parainfluenza Virus Vaccine (rHPIV3cp45) in Healthy Infants Completed NCT00308412 Phase 1
10 Evaluating the Live-Attenuated Human Parainfluenza Virus Type 3 Vectored Vaccine Candidate Expressing Ebolavirus Zaire Glycoprotein as the Sole Envelope Glycoprotein Recruiting NCT03462004 Phase 1
11 T-Lymphocytes for Prevention or Treatment of Viral Infections Following Hematopoietic Stem Cell Transplantation Recruiting NCT03180216 Phase 1
12 Safety, Reactogenicity, and Immunogenicity of mRNA-1653 in Healthy Adults Active, not recruiting NCT03392389 Phase 1
13 Study to Evaluate MEDI-534 in Healthy Adults Completed NCT00111878 MEDI-534

Search NIH Clinical Center for Parainfluenza Virus Type 3

Genetic Tests for Parainfluenza Virus Type 3

Anatomical Context for Parainfluenza Virus Type 3

MalaCards organs/tissues related to Parainfluenza Virus Type 3:

42
Bone, Bone Marrow, T Cells, Testes, Brain, Kidney, Monocytes

Publications for Parainfluenza Virus Type 3

Articles related to Parainfluenza Virus Type 3:

(show top 50) (show all 317)
# Title Authors Year
1
Epidemiological investigation and phylogenetic analysis of Caprine parainfluenza virus type 3 in sheep of China. ( 30770651 )
2019
2
Involvement of Actin-Regulating Factor Cofilin in the Inclusion Body Formation and RNA Synthesis of Human Parainfluenza Virus Type 3 via Interaction With the Nucleoprotein. ( 30792702 )
2019
3
Comparative Evaluation of the Immune Responses in Cattle Mammary Tissues Naturally Infected with Bovine Parainfluenza Virus Type 3 and Bovine Alphaherpesvirus-1. ( 30823555 )
2019
4
Virion-Associated Cholesterol Regulates the Infection of Human Parainfluenza Virus Type 3. ( 31096557 )
2019
5
Proteomics analysis reveals heat shock proteins involved in caprine parainfluenza virus type 3 infection. ( 31101113 )
2019
6
Inflammasome Antagonism by Human Parainfluenza Virus Type 3 C Protein. ( 29187536 )
2018
7
Human Parainfluenza Virus Type 3 Infections in Patients with Hematopoietic Stem Cell Transplants: the Mode of Nosocomial Infections and Prognosis. ( 29279454 )
2018
8
An alanine residue in human parainfluenza virus type 3 phosphoprotein is critical for restricting excessive N0-P interaction and maintaining N solubility. ( 29455063 )
2018
9
Functional analysis of amino acids at stalk/head interface of human parainfluenza virus type 3 hemagglutinin-neuraminidase protein in the membrane fusion process. ( 29516315 )
2018
10
Inclusion bodies of human parainfluenza virus type 3 inhibit antiviral stress granule formation by shielding viral RNAs. ( 29518158 )
2018
11
Human Parainfluenza Virus Type 3 Matrix Protein Reduces Viral RNA Synthesis of HPIV3 by Regulating Inclusion Body Formation. ( 29534486 )
2018
12
Analysis of microRNAs Expression Profiles in Madin-Darby Bovine Kidney Cells Infected With Caprine Parainfluenza Virus Type 3. ( 29651410 )
2018
13
A chimeric glycoprotein formulated with a combination adjuvant induces protective immunity against both human respiratory syncytial virus and parainfluenza virus type 3. ( 30071204 )
2018
14
Cellular microRNA bta-miR-222 suppresses caprine parainfluenza virus type 3 replication via downregulation of interferon regulatory factor 2. ( 30269791 )
2018
15
Screening and Identification of ssDNA Aptamers against HN Protein for Detection of Bovine Parainfluenza Virus Type 3 Antibodies in Serum. ( 30381069 )
2018
16
Maternal vaccination with a novel chimeric glycoprotein formulated with a polymer-based adjuvant provides protection from human parainfluenza virus type 3 in newborn lambs. ( 30550799 )
2018
17
Inclusion Body Fusion of Human Parainfluenza Virus Type 3 Regulated by Acetylated α-Tubulin Enhances Viral Replication. ( 27881643 )
2017
18
The Matrix Protein of Human Parainfluenza Virus Type 3 Induces Mitophagy that Suppresses Interferon Responses. ( 28407488 )
2017
19
A single L288I substitution in the fusion protein of bovine parainfluenza virus type 3 enhances virus growth in semi-suitable cell lines. ( 28451903 )
2017
20
Genetic analysis of human parainfluenza virus type 3 obtained in Croatia, 2011-2015. ( 28463659 )
2017
21
Identification of candidate protein markers of Bovine Parainfluenza Virus Type 3 infection using an in vitro model. ( 28619153 )
2017
22
Cholesterol-rich lipid rafts play a critical role in bovine parainfluenza virus type 3 (BPIV3) infection. ( 28654867 )
2017
23
Reciprocal complementation of bovine parainfluenza virus type 3 lacking either the membrane or fusion gene. ( 28842134 )
2017
24
Development of a blocking ELISA for Caprine parainfluenza virus type 3. ( 28966036 )
2017
25
Vaccination with a human parainfluenza virus type 3 chimeric FHN glycoprotein formulated with a combination adjuvant induces protective immunity. ( 29153777 )
2017
26
Complete Genome Sequences of Two Human Parainfluenza Virus Type 3 Isolates Collected in Brazil. ( 29217788 )
2017
27
Parainfluenza virus type 3 outbreak in a neonatal intensive care unit. ( 29359411 )
2017
28
Surveillance, isolation and complete genome sequence of bovine parainfluenza virus type 3 in Egyptian cattle. ( 30255042 )
2017
29
Exploring inhibitor structural features required to engage the 216-loop of human parainfluenza virus type-3 hemagglutinin-neuraminidase. ( 30108698 )
2017
30
A parainfluenza virus type 3 outbreak at a residential aged care facility: The role of microbiologic testing in early identification and antimicrobial stewardship. ( 27665033 )
2017
31
Identification of Interferon-Stimulated Gene Proteins That Inhibit Human Parainfluenza Virus Type 3. ( 27707917 )
2016
32
A molecular epidemiological study of human parainfluenza virus type 3 at a tertiary university hospital during 2013-2015 in Catalonia, Spain. ( 27524509 )
2016
33
Rapid detection of novel caprine parainfluenza virus type 3 (CPIV3) using a TaqMan-based RT-qPCR. ( 27448824 )
2016
34
Pathogenicity and horizontal transmission studies of caprine parainfluenza virus type 3 JS2013 strain in goats. ( 27374058 )
2016
35
Viral protein requirements for assembly and release of human parainfluenza virus type 3 virus-like particles. ( 26960133 )
2016
36
Epidemiology and clinical outcome of lower respiratory tract infections by respiratory syncytial virus or parainfluenza virus type 3 in adults receiving treatment for either acute leukemia or severe aplastic anemia: a retrospective single center study. ( 26204825 )
2015
37
Catalytic mechanism and novel receptor binding sites of human parainfluenza virus type 3 hemagglutinin-neuraminidase (hPIV3 HN). ( 26364554 )
2015
38
Interaction of Human Parainfluenza Virus Type 3 Nucleoprotein with Matrix Protein Mediates Internal Viral Protein Assembly. ( 26656716 )
2015
39
Mutations in the DI-DII Linker of Human Parainfluenza Virus Type 3 Fusion Protein Result in Diminished Fusion Activity. ( 26305905 )
2015
40
Development and evaluation of two truncated recombinant NP antigen-based indirect ELISAs for detection of bovine parainfluenza virus type 3 antibodies in cattle. ( 26031225 )
2015
41
Identification of three antigen epitopes on the nucleocapsid protein of the genotype C of bovine parainfluenza virus type 3. ( 25960335 )
2015
42
Amino acid substitutions contributing to α2,6-sialic acid linkage binding specificity of human parainfluenza virus type 3 hemagglutinin-neuraminidase. ( 25871520 )
2015
43
Human parainfluenza virus type 3 (HPIV3) induces production of IFNγ and RANTES in human nasal epithelial cells (HNECs). ( 25722655 )
2015
44
The catalytic mechanism of human parainfluenza virus type 3 haemagglutinin-neuraminidase revealed. ( 25676091 )
2015
45
The aberrant gene-end transcription signal of the matrix M gene of human parainfluenza virus type 3 downregulates fusion F protein expression and the F-specific antibody response in vivo. ( 25589643 )
2015
46
Infection of the upper respiratory tract of hamsters by the bovine parainfluenza virus type 3 BN-1 strain expressing enhanced green fluorescent protein. ( 25543964 )
2015
47
Complete genome sequence of the first isolate of genotype C bovine parainfluenza virus type 3 in Japan. ( 25428970 )
2014
48
A novel parainfluenza virus type 3 (PIV3) identified from goat herds with respiratory diseases in eastern China. ( 25236986 )
2014
49
A leucine residue in the C terminus of human parainfluenza virus type 3 matrix protein is essential for efficient virus-like particle and virion release. ( 25187547 )
2014
50
Parainfluenza virus type 3 Ab in allogeneic hematopoietic cell transplant recipients: factors influencing post-transplant Ab titers and associated outcomes. ( 24978141 )
2014

Variations for Parainfluenza Virus Type 3

Expression for Parainfluenza Virus Type 3

Search GEO for disease gene expression data for Parainfluenza Virus Type 3.

Pathways for Parainfluenza Virus Type 3

GO Terms for Parainfluenza Virus Type 3

Sources for Parainfluenza Virus Type 3

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