MCID: PRL008
MIFTS: 43

Paralytic Ileus

Categories: Gastrointestinal diseases

Aliases & Classifications for Paralytic Ileus

MalaCards integrated aliases for Paralytic Ileus:

Name: Paralytic Ileus 12 15 72 33

Classifications:



External Ids:

Disease Ontology 12 DOID:8442
ICD9CM 35 560.1
MeSH 44 D007418
NCIt 50 C93045
SNOMED-CT 68 55525008
ICD10 33 K56.0
UMLS 72 C0030446

Summaries for Paralytic Ileus

MalaCards based summary : Paralytic Ileus is related to intestinal pseudo-obstruction and mitochondrial neurogastrointestinal encephalomyopathy. An important gene associated with Paralytic Ileus is ABCB1 (ATP Binding Cassette Subfamily B Member 1), and among its related pathways/superpathways are Eicosanoid ligand-binding receptors and Ibuprofen Pathway, Pharmacodynamics. The drugs Peppermint and Clavulanate have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and liver, and related phenotype is no phenotypic analysis.

Related Diseases for Paralytic Ileus

Diseases related to Paralytic Ileus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
# Related Disease Score Top Affiliating Genes
1 intestinal pseudo-obstruction 33.5 TYMP MT-TL1
2 mitochondrial neurogastrointestinal encephalomyopathy 30.4 TYMP MT-TK
3 mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes 30.2 TYMP MT-TL1
4 pain agnosia 30.0 CNR1 CCK
5 kearns-sayre syndrome 29.8 TYMP MT-TL1
6 mitochondrial encephalomyopathy 29.0 MT-TL1 MT-TK
7 ileus 11.6
8 peritonitis 10.6
9 intestinal obstruction 10.6
10 constipation 10.5
11 pheochromocytoma 10.5
12 adrenal gland pheochromocytoma 10.5
13 intussusception 10.4
14 intestinal volvulus 10.4
15 intestinal impaction 10.4
16 autonomic neuropathy 10.4
17 hypothyroidism 10.4
18 hypokalemia 10.4
19 appendicitis 10.4
20 strongyloidiasis 10.3
21 neuropathy 10.3
22 systemic lupus erythematosus 10.3
23 pancreatitis 10.3
24 myeloma, multiple 10.2
25 hydrops, lactic acidosis, and sideroblastic anemia 10.2
26 colitis 10.2
27 lymphocytic leukemia 10.2
28 megacolon 10.2
29 pulmonary edema 10.2
30 diarrhea 10.2
31 toxic megacolon 10.2
32 acute pancreatitis 10.2
33 peripheral nervous system disease 10.2
34 herpes zoster 10.2
35 lupus erythematosus 10.2
36 opioid addiction 10.2 CCK ABCB1
37 gastroparesis 10.2 CCK ABCB1
38 space motion sickness 10.1 CCK AVP
39 multiple sclerosis 10.1
40 scleroderma, familial progressive 10.1
41 myxedema 10.1
42 acute promyelocytic leukemia 10.1
43 leukemia, acute lymphoblastic 10.1
44 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.1
45 exanthem 10.1
46 metabolic acidosis 10.1
47 clostridium difficile colitis 10.1
48 cardiac arrest 10.1
49 thrombosis 10.1
50 malignant pheochromocytoma 10.1

Comorbidity relations with Paralytic Ileus via Phenotypic Disease Network (PDN): (show top 50) (show all 76)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Pancreatitis
Acute Vascular Insufficiency of Intestine Alzheimer Disease
Anxiety Aortic Aneurysm
Ascending Colon Cancer Atrophic Gastritis
Bladder Cancer Bronchitis
Bronchopneumonia Candidiasis
Cecal Benign Neoplasm Cholangitis
Cholecystitis Cholestasis
Chronic Intestinal Vascular Insufficiency Chylomicron Retention Disease
Colorectal Cancer Cystitis
Decubitus Ulcer Deficiency Anemia
Dermatomycosis Descending Colon Cancer
Duodenitis Dysthymic Disorder
Enterovesical Fistula Esophageal Disease
Esophagitis Familial Atrial Fibrillation
Generalized Atherosclerosis Heart Disease
Hepatic Flexure Cancer Hydronephrosis
Hypertension, Essential Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome
Hypothyroidism Inflammatory Bowel Disease 1
Intestinal Disease Intestinal Obstruction
Intestinal Perforation Intestinal Volvulus
Iron Deficiency Anemia Irritable Bowel Syndrome
Kidney Disease Kwashiorkor
Major Depressive Disorder Mallory-Weiss Syndrome

Graphical network of the top 20 diseases related to Paralytic Ileus:



Diseases related to Paralytic Ileus

Symptoms & Phenotypes for Paralytic Ileus

MGI Mouse Phenotypes related to Paralytic Ileus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 8.92 ABCB1 AVP CCK CNR1

Drugs & Therapeutics for Paralytic Ileus

Drugs for Paralytic Ileus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Peppermint Approved Phase 4
2
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
3
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
4
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
5
Remifentanil Approved Phase 4 132875-61-7 60815
6
Tapentadol Approved Phase 4 175591-23-8 9838022
7
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
8
Morphine Approved, Investigational Phase 4 57-27-2 5288826
9
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
10
Racepinephrine Approved Phase 4 329-65-7 838
11
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
12
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
13
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
14
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
15
Cimetropium Experimental, Investigational Phase 4 150521-16-7
16 Pharmaceutical Solutions Phase 4
17 Parasympatholytics Phase 4
18 Cholinergic Agents Phase 4
19 Cola Phase 4
20 Cholinergic Antagonists Phase 4
21 Bromides Phase 4
22 Autonomic Agents Phase 4
23 Anti-Bacterial Agents Phase 4
24 Anti-Infective Agents Phase 4
25 Antitubercular Agents Phase 4
26 Antibiotics, Antitubercular Phase 4
27 beta-Lactamase Inhibitors Phase 4
28 Calcium, Dietary Phase 4
29 Neurotransmitter Agents Phase 4
30 Anticonvulsants Phase 4
31 Sodium Channel Blockers Phase 4
32 Narcotics Phase 4
33 Diuretics, Potassium Sparing Phase 4
34 Analgesics, Opioid Phase 4
35 Anti-Arrhythmia Agents Phase 4
36 Tranquilizing Agents Phase 4
37 Hormones Phase 4
38 Anti-Anxiety Agents Phase 4
39 Neurotransmitter Uptake Inhibitors Phase 4
40 Psychotropic Drugs Phase 4
41 Adrenergic Agents Phase 4
42 calcium channel blockers Phase 4
43 Anesthetics Phase 4
44 Peripheral Nervous System Agents Phase 4
45 Anesthetics, Local Phase 4
46 Central Nervous System Depressants Phase 4
47 Analgesics Phase 4
48 Epinephryl borate Phase 4
49 Mosapride Investigational Phase 3 112885-41-3
50 Gastrointestinal Agents Phase 3

Interventional clinical trials:

(show all 31)
# Name Status NCT ID Phase Drugs
1 Usefulness Of Flospan As A Premedication For Colonoscopy : A Randomized Double Blind Controlled Trial Unknown status NCT01842932 Phase 4 Phloroglucin;Cimetropium bromide;Placebo
2 Influence of Gum Chewing on Postoperative Bowel Activity After Complete Staging Surgery for Gynecological Malignancies Unknown status NCT01835119 Phase 4 gum
3 Non Operative Treatment for Acute Appendicitis: Study on Efficacy and Safety of Antibiotic Treatment (Amoxicillin and Clavulanic Acid) in Patients With Right Sided Lower Abdominal Pain Completed NCT01096927 Phase 4 Amoxicillin and Clavulanic Acid
4 Efficacy of the Liposomal Bupivacaine for Postoperative Pain Control in Urologic Procedures Recruiting NCT02805504 Phase 4 Exparel;Marcaine
5 Impact of the Administration of Intravenous or Paravertebral Lidocaine in Continuous Perfusion During the Intraoperative Period of Lung Resection Surgery on the Appearance of Postoperative Complications Recruiting NCT03905837 Phase 4 Lidocaine;Remifentanil
6 Safety and Efficacy of Pre-emptive Tapentadol vs Pregabalin in Post Operative Pain Following Unilateral Total Knee Arthroplasty- A Randomised, Double Blind, Active Control, Clinical Trial Recruiting NCT03604354 Phase 4 Tapentadol 100 MG Oral Tablet;Pregabalin 150mg
7 Outcomes After Total Knee Joint Arthroplasty: A Comparative Study Using 3 Different Analgesic Techniques Terminated NCT01503528 Phase 4
8 Effects of Gum Chewing on Recovery of Bowel Function Following Benign Gynecologic Surgery: a Randomized Controlled Trial Unknown status NCT01394094 Phase 2, Phase 3
9 Effect of Smoked Plum and Chewing Gum on Postoperative Bowel Function Following Hepatic Resection Unknown status NCT02649153 Phase 3 smoked plum;gum chewing
10 The Effects of Gum Chewing on Bowel Function Recovery Following Cesarean Section: Randomized Controlled Trial Completed NCT01131416 Phase 2, Phase 3
11 Effectiveness of Mouth Dissolving Mosapride Tablets on Enhancing Gut Recovery After Cesarean Section: Randomized Double-blind, Placebo-controlled Clinical Trial Completed NCT03477266 Phase 3 Mosapride;Placebo Oral Tablet
12 Fluid Management Guided With Lactate Clearance Versus Central Venous Oxygen Saturation Monitoring in Surgical Patients in Intensive Care Unit. Completed NCT03455296 Phase 2, Phase 3
13 Effects of Gum Chewing on Recovery of Bowel Function Following Abdominal Surgery for Endometrial and Ovarian Cancer: a Randomized Controlled Trial Withdrawn NCT01389986 Phase 2, Phase 3
14 Regular Versus Liquid Diet as the First Meal in Patients Undergoing Major Abdominal Gynecologic Cancer Operation: A Randomized Controlled Trial Withdrawn NCT00328757 Phase 3
15 Effect of Daikenchuto (TJ-100) on Intestinal Dysmotility and For the Prevention of Postoperative Paralytic Ileus in Patients Undergoing Pancreaticoduodenectomy: A Multicenter, Randomized, Placebo-Controlled Phase II Trial Unknown status NCT01607307 Phase 2 Oral/enteral TJ-100 solution;Oral/enteral placebo solution
16 Perioperative Systemic Lidocaine for Enhanced Bowel Recovery After Laparoscopic Bariatric Surgery: A Dose Dependent Study Unknown status NCT02607488 Phase 1, Phase 2 Placebo;Lidocaine 1%;Lidocaine 1.5%;Lidocaine 2%
17 Acupuncture to Prevent Postoperative Paralytic Ileus Terminated NCT00065234 Phase 2
18 Effects of Laser Acupuncture Therapy on Paralytic Ileus Unknown status NCT03041675
19 Is Nasogastric Tube Necessary After Pancreaticoduodenectomy? A Prospective Randomized Multicenter Trial Unknown status NCT01966406
20 Gastric Artery Embolization Trial for Lessening Appetite Nonsurgically (GET LEAN) Unknown status NCT02248688
21 Is Nasogastric Tube Necessary After Pancreaticoduodenectomy? Unknown status NCT01991392
22 Australasian Multicentered Prospective Randomised Clinical Study Comparing Laparoscopic and Conventional Open Surgical Treatments of Colon Cancer in Adults Unknown status NCT00202111
23 Effectiveness of Gum Chewing on Reduction of Postoperative Paralytic Ileus for Chinese Colorectal Cancer Patients Underwent Laparoscopic Colorectal Surgery and Enhanced Recovery Program Completed NCT02419586
24 Burst Abdomen in Emergency Midline Laparotomy: Incidence and Risk Completed NCT03684902
25 The Effect of Caffeine Ingestion in Prevention of Postoperative Ileus After Caesarean Section: A Randomized Controlled Trial Completed NCT03815877
26 Phase 4 Study, Open, Observational, to Evaluate the Safety and Tolerability of Hydrochloride Controlled-release Oxycodone in Moderate and Severe Postoperative Pain in Oncologic Head and Neck Surgery. Completed NCT01834898 Controlled-release oxycodone
27 Diagnostic Accuracy of Increased Serum Cytokine Levels as a Marker of Paralytic Ileus Following Robotic Radical Cystectomy Recruiting NCT03982498
28 Short Versus Standard Post-operative Stay After Elective Cesarean Delivery Recruiting NCT03355378
29 Transurethral Versus Percutaneous Endoscopic Management of Bladder Stones in Boys: A Comparative Prospective Randomized Study Recruiting NCT03294239
30 Lateral Suspension Versus Sacropexy for Treatment of Apical Pelvic Organ Prolapse: Randomized Controlled Trial Not yet recruiting NCT03772691
31 Neurostimulation for the Treatment of Post-Operative Ileus Withdrawn NCT00854074

Search NIH Clinical Center for Paralytic Ileus

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Panthenol

Genetic Tests for Paralytic Ileus

Anatomical Context for Paralytic Ileus

MalaCards organs/tissues related to Paralytic Ileus:

41
Colon, Small Intestine, Liver, Kidney, Lung, Testes, Spinal Cord

Publications for Paralytic Ileus

Articles related to Paralytic Ileus:

(show top 50) (show all 1154)
# Title Authors PMID Year
1
Perioperative complications associated with minimally invasive surgery of oblique lumbar interbody fusions for degenerative lumbar diseases in 113 patients. 38
31302382 2019
2
Mechanical small bowel obstruction due to appendiceal tourniquet: a case report and review of literature. 38
31391122 2019
3
Paralytic ileus precipitating platypnoea-orthodeoxia after right pneumonectomy. 38
31363746 2019
4
Paralytic ileus in the patient with tuberculosis of spine. 38
31307238 2019
5
Feasibility of perioperative volatile organic compound breath testing for the prediction of paralytic ileus following laparoscopic colorectal resection. 38
31344300 2019
6
Impact of pre-operative walking on post-operative bowel function in patients with gynecologic cancer. 38
31326951 2019
7
Removal of pediatric stage IV neuroblastoma by robot-assisted laparoscopy: A case report and literature review. 38
31363479 2019
8
Preoperative Neutrophil-lymphocyte Ratio Is a Predictor of High-output Ileostomy After Colorectal Surgery. 38
31177177 2019
9
Relapsing paralytic ileus in multiple sclerosis requiring surgery: a video case report. 38
30415400 2019
10
Factors predictive of high-output ileostomy: a retrospective single-center comparative study. 38
30594951 2019
11
In-vitro fertilization resulting in heterotopic pregnancy, ovarian hyperstimulation and paralytic ileus: A case report. 38
30923681 2019
12
[Comparison of the minimally invasive treatments of laparoscopic and endosopic for common bile duct stones after gastrojejunostomy]. 38
30996380 2019
13
Postoperative paralytic ileus after major oncological procedures in the enhanced recovery after surgery era: A population based analysis. 38
30851901 2019
14
Pus Samples in Complicated Appendicitis: An Important Investigation or a Waste of Resources: A Prospective Cohort Study. 38
29973114 2019
15
Does Postoperative Rehabilitation for Radical Cystectomy Call for Enhanced Recovery after Surgery? A Systematic Review and Meta-analysis. 38
30868498 2019
16
[Single balloon enteroscopy in the management of small bowel pathology. Experience of the Small Bowel Unit - British American Hospital from December 2012 to December 2018]. 38
31042234 2019
17
[A body packer with cannabis]. 38
30719888 2019
18
Pneumatosis intestinalis and hepatic portal venous gas associated with gas-forming bacterial translocation due to postoperative paralytic ileus: A case report. 38
30633214 2019
19
Submucosal mucoid as a late complication after appendectomy-A case report. 38
31003092 2019
20
Gastrointestinal complications following on-pump cardiac surgery-A propensity matched analysis. 38
31166962 2019
21
Can Intestinal Pseudo-Obstruction Drive Recurrent Stroke-Like Episodes in Late-Onset MELAS Syndrome? A Case Report and Review of the Literature. 38
30766507 2019
22
Novel approach to intraoperative peritoneal lavage with an extracorporeal stirring method in laparoscopic surgery for generalized peritonitis: Preliminary results. 38
30672137 2019
23
First Nationwide Survey of 199 Patients with Amyloid A Amyloidosis in Japan. 38
30101921 2018
24
Outcome of Bowel Resection in Women with Advanced Ovarian Carcinoma. 38
30538381 2018
25
Laparoscopic Pelvic Exenteration for Locally Advanced Rectal Cancer, Technique and Short-Term Outcomes. 38
29741977 2018
26
Anti-ganglionic AChR antibodies in Japanese patients with motility disorders. 38
29766276 2018
27
The value of the erect abdominal radiograph for the diagnosis of mechanical bowel obstruction and paralytic ileus in adults presenting with acute abdominal pain. 38
30039624 2018
28
Abdominal radiographs in the emergency department: current status and controversies. 38
30506851 2018
29
POLYSEROSITIS AND SEVERE SEPSIS AFTER OPEN SUPRAPUBIC RADICAL PROSTATECTOMY: A CASE REPORT. 38
31168220 2018
30
Learning Curve of Minimally Invasive Surgery Oblique Lumbar Interbody Fusion for Degenerative Lumbar Diseases. 38
30071338 2018
31
The Association of Shorter Interval of Biopsy-Radical Prostatectomy and Surgical Difficulty. 38
30006922 2018
32
Intracorporeal versus extracorporeal anastomosis in right hemicolectomy assisted by laparoscopy: study protocol for a randomized controlled trial. 38
30191370 2018
33
Protective loop ileostomy increases the risk for prolonged postoperative paralytic ileus after open oncologic rectal resection. 38
30112664 2018
34
Giant Splenic Aneurysm with Arteriovenous (A-V) Shunt, Portal Hypertension, and Ascites. 38
30478253 2018
35
Robot resection of a choledochal cyst with Roux-en-y hepaticojejunostomy in adults: Initial experiences with 22 cases and a comparison with laparoscopic approaches. 38
30588527 2018
36
Use of ileum for complex ureteric reconstruction: Assessment of long-term outcome, complications, and impact on renal function. 38
30386088 2018
37
The effect of gum chewing on the return of bowel motility after planned cesarean delivery: a randomized controlled trial. 38
30231787 2018
38
Paralytic Ileus and Syndrome of Inappropriate Antidiuretic Hormone Secretion Potentially due to an Interaction Between Vincristine and Voriconazole/Posaconazole. 38
30418228 2018
39
Getting Your Grumble Back. 38
27708119 2018
40
Burden of gastrointestinal and liver diseases in India, 1990-2016. 38
30306342 2018
41
Gastrointestinal Complications After Surgical Correction of Neuromuscular Scoliosis: A Retrospective Cohort Study. 38
29268665 2018
42
Complications within 90 days after radical cystectomy for bladder cancer: results of a multicenter prospective study in Japan. 38
29442282 2018
43
Hiatal hernia involving prolapse of the entire stomach into the mediastinum after distal gastrectomy: a case report. 38
30105511 2018
44
Small-Bowel Paralytic Ileus From Strongyloides stercoralis. 38
30144518 2018
45
[Zhu's trocar placement in laparoscopic appendectomy in the treatment of complicated appendicitis]. 38
30136273 2018
46
Robot-sewn ileoileal anastomosis during robot-assisted cystectomy. 38
29500511 2018
47
[Peritonitis treated by laparoscopy as an effective treatment]. 38
30540730 2018
48
Robot-assisted radical nephroureterectomy with extended template lymphadenectomy for upper tract urothelial carcinoma: An outcome analysis. 38
30034133 2018
49
Mechanical Reinforced Terminolateral Ileo-Transverse Anastomosis: An Option After Right Hemicolectomy-A 452 Patients Study. 38
29985519 2018
50
Epidemiology of intussusception before and after rotavirus vaccine introduction in Fiji. 38
30046133 2018

Variations for Paralytic Ileus

Expression for Paralytic Ileus

Search GEO for disease gene expression data for Paralytic Ileus.

Pathways for Paralytic Ileus

Pathways related to Paralytic Ileus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.84 CNR2 CNR1
2 10.4 CNR2 CNR1
3 9.74 CNR1 CCK

GO Terms for Paralytic Ileus

Cellular components related to Paralytic Ileus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 8.8 CNR2 CCK AVP

Biological processes related to Paralytic Ileus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.76 CNR2 CNR1 CCK AVP
2 memory GO:0007613 9.48 CNR1 CCK
3 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.43 CNR2 CNR1
4 sensory perception of pain GO:0019233 9.4 CNR2 CNR1
5 response to nicotine GO:0035094 9.37 CNR1 AVP
6 negative regulation of nitric-oxide synthase activity GO:0051001 9.32 CNR2 CNR1
7 positive regulation of glutamate secretion GO:0014049 9.26 CCK AVP
8 negative regulation of mast cell activation GO:0033004 9.16 CNR2 CNR1
9 negative regulation of action potential GO:0045759 8.96 CNR2 CNR1
10 cannabinoid signaling pathway GO:0038171 8.62 CNR2 CNR1

Molecular functions related to Paralytic Ileus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 8.96 CCK AVP
2 cannabinoid receptor activity GO:0004949 8.62 CNR2 CNR1

Sources for Paralytic Ileus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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