MCID: PRL008
MIFTS: 45

Paralytic Ileus

Categories: Gastrointestinal diseases

Aliases & Classifications for Paralytic Ileus

MalaCards integrated aliases for Paralytic Ileus:

Name: Paralytic Ileus 12 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:8442
ICD9CM 34 560.1
MeSH 44 D007418
NCIt 50 C93045
SNOMED-CT 67 155773004
ICD10 32 K56.0
UMLS 71 C0030446

Summaries for Paralytic Ileus

MalaCards based summary : Paralytic Ileus is related to ileus and peritonitis. An important gene associated with Paralytic Ileus is MLN (Motilin), and among its related pathways/superpathways are Folate Metabolism and Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics. The drugs Prucalopride and Cathartics have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and kidney, and related phenotypes are digestive/alimentary and immune system

Related Diseases for Paralytic Ileus

Diseases related to Paralytic Ileus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 543)
# Related Disease Score Top Affiliating Genes
1 ileus 31.5 VIP MLN INS F2 CRP
2 peritonitis 31.0 F2 CRP ALB
3 autonomic neuropathy 30.6 MLN INS ALB
4 gastroenteritis 30.5 MLN CRP ALB
5 intussusception 30.4 VIP CRP ALB
6 acute pancreatitis 30.2 INS GPT CRP
7 pain agnosia 30.2 TCF21 TAC1 ALB
8 metabolic acidosis 30.2 GPT F2 ALB
9 anuria 30.2 F2 CRP ALB
10 thrombophlebitis 30.2 F2 CRP ALB
11 cholecystitis 30.1 GPT F2 ALB
12 polyneuropathy 30.1 INS CRP ALB
13 pneumatosis cystoides intestinalis 30.1 MLN ATP4A ATP12A
14 toxic megacolon 29.9 CRP ATP4A ATP12A ALB
15 pleural empyema 29.9 GPT F2 CRP ALB
16 neurogenic bladder 29.8 TAC1 CRP ALB
17 clostridium difficile colitis 29.8 CRP ATP4A ATP12A ALB
18 neurogenic bowel 29.8 VIP TAC1 MLN
19 intestinal obstruction 29.7 TCF21 MLN GPT CRP ATP4A ATP12A
20 pneumonia 29.7 GPT F2 CRP AVP ALB
21 pre-eclampsia 29.6 INS F2 CRP ALB
22 neutropenia 29.6 GPT CYP3A4 CRP ALB ABCB1
23 aspiration pneumonitis 29.6 CRP ATP4A ATP12A ALB
24 diverticulitis 29.6 CRP ATP4A ATP12A ALB
25 hypothyroidism 29.6 INS GPT F2 CRP ATP4A ALB
26 active peptic ulcer disease 29.5 F2 ATP4A ATP12A ALB
27 respiratory failure 29.4 TAC1 GPT F2 CRP ALB
28 peripheral nervous system disease 29.4 TAC1 INS GPT CRP ALB
29 liver disease 29.3 INS GPT F2 CYP3A4 ALB
30 diarrhea 29.2 TAC1 MLN GPT CYP3A4 ALB ABCB1
31 volvulus of midgut 29.1 MLN GPT F2 CRP ATP4A ATP12A
32 exanthem 28.8 GPT F2 CYP3A4 CRP ATP4A ATP12A
33 constipation 28.1 VIP TAC1 MLN INS GPT CYP3A4
34 intestinal pseudo-obstruction 11.4
35 pheochromocytoma 10.4
36 adrenal gland pheochromocytoma 10.4
37 intestinal tuberculosis 10.4 CRP ALB
38 chronic duodenal ileus 10.4 CRP ALB
39 phenytoin toxicity 10.4 ALB ABCB1
40 pericoronitis 10.4 TCF21 CRP
41 space motion sickness 10.4 MLN AVP
42 ankylosing spondylitis 3 10.4 CRP ALB
43 orbital osteomyelitis 10.4 F2 CRP
44 soft tissue sarcoma 10.4 CRP ABCB1
45 tuberculous peritonitis 10.4 CRP ALB
46 achenbach syndrome 10.3 F2 CRP
47 small intestine diverticulitis 10.3 F2 CRP
48 renal pelvis squamous cell carcinoma 10.3 F2 CRP
49 meningovascular neurosyphilis 10.3 CRP ALB
50 synovial angioma 10.3 F2 CRP

Comorbidity relations with Paralytic Ileus via Phenotypic Disease Network (PDN): (show top 50) (show all 75)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Pancreatitis
Acute Vascular Insufficiency of Intestine Alzheimer Disease
Anxiety Aortic Aneurysm
Ascending Colon Cancer Atrophic Gastritis
Bladder Cancer Bronchitis
Bronchopneumonia Candidiasis
Cecal Benign Neoplasm Cholangitis
Cholecystitis Cholestasis
Chronic Intestinal Vascular Insufficiency Chylomicron Retention Disease
Colorectal Cancer Cystitis
Decubitus Ulcer Deficiency Anemia
Dermatomycosis Descending Colon Cancer
Duodenitis Dysthymic Disorder
Enterovesical Fistula Esophageal Disease
Esophagitis Familial Atrial Fibrillation
Generalized Atherosclerosis Heart Disease
Hepatic Flexure Cancer Hydronephrosis
Hypertension, Essential Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome
Hypothyroidism Inflammatory Bowel Disease 1
Intestinal Disease Intestinal Obstruction
Intestinal Perforation Iron Deficiency Anemia
Irritable Bowel Syndrome Kidney Disease
Kwashiorkor Major Depressive Disorder
Mallory-Weiss Syndrome Marasmus

Graphical network of the top 20 diseases related to Paralytic Ileus:



Diseases related to Paralytic Ileus

Symptoms & Phenotypes for Paralytic Ileus

MGI Mouse Phenotypes related to Paralytic Ileus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.7 ABCB1 ALB ATP12A ATP4A F2 INS
2 immune system MP:0005387 9.61 ABCB1 ALB ATP4A AVP CRP F2
3 normal MP:0002873 9.17 ALB AVP F2 INS TAC1 TCF21

Drugs & Therapeutics for Paralytic Ileus

Drugs for Paralytic Ileus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prucalopride Approved Phase 3 179474-81-8
2 Cathartics Phase 3
3 Gastrointestinal Agents Phase 3
4 Serotonin Receptor Agonists Phase 3
5 Neurotransmitter Agents Phase 3
6 Laxatives Phase 3
7
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
8 Pharmaceutical Solutions Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effects of Gum Chewing on Bowel Function Recovery Following Cesarean Section: Randomized Controlled Trial Completed NCT01131416 Phase 2, Phase 3
2 Efficacy of Prucalopride in Critically Ill Patients With Paralytic Ileus; a Pilot Randomized Double-blind Controlled Trial Recruiting NCT04190173 Phase 3 Prucalopride;Placebo
3 Effects of Gum Chewing on Recovery of Bowel Function Following Abdominal Surgery for Endometrial and Ovarian Cancer: a Randomized Controlled Trial Withdrawn NCT01389986 Phase 2, Phase 3
4 Effect of Daikenchuto (TJ-100) on Intestinal Dysmotility and For the Prevention of Postoperative Paralytic Ileus in Patients Undergoing Pancreaticoduodenectomy: A Multicenter, Randomized, Placebo-Controlled Phase II Trial Unknown status NCT01607307 Phase 2 Oral/enteral TJ-100 solution;Oral/enteral placebo solution
5 Acupuncture to Prevent Postoperative Paralytic Ileus Terminated NCT00065234 Phase 2
6 Effects of Laser Acupuncture Therapy on Paralytic Ileus Unknown status NCT03041675
7 Effectiveness of Gum Chewing on Reduction of Postoperative Paralytic Ileus for Chinese Colorectal Cancer Patients Underwent Laparoscopic Colorectal Surgery and Enhanced Recovery Program Completed NCT02419586
8 Diagnostic Accuracy of Increased Serum Cytokine Levels as a Marker of Paralytic Ileus Following Robotic Radical Cystectomy Recruiting NCT03982498
9 Gum Chewing Reduces the Risk of Postoperative Ileus After Arthroplasty Procedures in The Elderly Population: A Parallel Design, Open-Label, Randomized Controlled Trial Not yet recruiting NCT04489875

Search NIH Clinical Center for Paralytic Ileus

Genetic Tests for Paralytic Ileus

Anatomical Context for Paralytic Ileus

MalaCards organs/tissues related to Paralytic Ileus:

40
Small Intestine, Colon, Kidney, Spinal Cord, Pancreas, Appendix, Uterus

Publications for Paralytic Ileus

Articles related to Paralytic Ileus:

(show top 50) (show all 1222)
# Title Authors PMID Year
1
Case 2: Abdominal Distention with Paralytic Ileus in a Neonate. 61
33526642 2021
2
Meta-analysis of randomised controlled trials comparing intracorporeal versus extracorporeal anastomosis in laparoscopic right hemicolectomy: upgrading the level of evidence. 61
33534124 2021
3
Early intestinal complications following pancreas transplantation: lessons learned from over 300 cases - a retrospective single-center study. 61
33084117 2021
4
Paralytic ileus after planned abdominal surgery in a patient on treatment with erenumab. 61
32557089 2021
5
Salvage robotic anterior pelvic exenteration for cervical cancer: technique and feasibility. 61
33515209 2021
6
Improvement of COVID-19 with renal failure and paralytic ileus by using steroids. 61
33282314 2021
7
Gastrointestinal: Refractory paralytic ileus cured by immunotherapy, a case of natural killer cell neoplasm-induced polyneuropathy. 61
33305415 2020
8
Paralytic ileus in the patient with tuberculosis of spine. 61
31307238 2020
9
Severe gastrointestinal symptoms caused by a novel DDX3X variant. 61
32896648 2020
10
The Role of Nutritional Access in Malnourished Elderly Undergoing Major Surgery for Acute Abdomen: A Propensity Score-Matched Analysis. 61
33345560 2020
11
Are Paula method exercises effective for gastrointestinal reactivation post-elective cesarean delivery? Randomized controlled trial. 61
33249611 2020
12
Open Conversion After Endovascular Aneurysm Sealing: Technical Features and Clinical Outcomes in 44 Patients. 61
33236681 2020
13
Postoperative ileus-An ongoing conundrum. 61
33252179 2020
14
Revascularization-first strategy in acute aortic dissection with mesenteric malperfusion. 61
32840908 2020
15
What Does a Diagnosis of Depression Mean for Patients Undergoing Colorectal Surgery? 61
33272593 2020
16
Chewing gum promotes bowel function recovery in elderly patients after lumbar spinal surgery: a retrospective single-center cohort study. 61
33183031 2020
17
Case Report: Paralytic Ileus: A Potential Extrapulmonary Manifestation of Severe COVID-19. 61
32876011 2020
18
Beyond Picky Eating. 61
32826694 2020
19
A Rare Complication of Ileus Following Endoscopic Ultrasound-Guided Celiac Plexus Neurolysis: A Case Report. 61
33209522 2020
20
Clozapine in the treatment of refractory schizophrenia: a practical guide for healthcare professionals. 61
32885238 2020
21
Role of Laparoscopic Appendicectomy in the Treatment of Acute Appendicitis and Its Complications. 61
33116092 2020
22
Procedural and post-operative complications associated with laparoscopic versus open abdominal surgery for right-sided colonic cancer resection: A systematic review and meta-analysis. 61
33019422 2020
23
Creation and Institutional Validation of a Readmission Risk Calculator for Elective Colorectal Surgery. 61
32969887 2020
24
Incidence and Risk Factors of Gastrointestinal and Hepatobiliary Complications after Spinal Fusion Surgery: a Retrospective Cohort Study. 61
33075855 2020
25
Spinal Deformity Surgery in Pediatric Patients With Cerebral Palsy: A National-Level Analysis of Inpatient and Postdischarge Outcomes. 61
32964747 2020
26
Comparison of extended right hemicolectomy, left hemicolectomy and segmental colectomy for splenic flexure colon cancer: a systematic review and meta-analysis. 61
32757361 2020
27
Pneumatosis intestinalis and hepatic portal venous gas in paralytic ileus due to Strongyloides stercoralis infestation. 61
32388970 2020
28
Comparison of the Safety and Efficacy between Transperitoneal and Retroperitoneal Approach of Laparoscopic Ureterolithotomy for the Treatment of Large (>10mm) and Proximal Ureteral Stones: A Systematic Review and Meta-analysis. 61
32748392 2020
29
Technical approach, outcomes, and exposure-related complications in patients undergoing anterior lumbar interbody fusion. 61
32707392 2020
30
Efficacy of ultrasound guided quadratus lumborum block as postoperative analgesia in renal transplantation recipients: A randomised double blind clinical study. 61
32792737 2020
31
Totally robotic right hemicolectomy: a multicentre case-matched technical and peri-operative comparison of port placements and da Vinci models. 61
31468314 2020
32
Constipation screening in people taking clozapine: A diagnostic accuracy study. 61
32245597 2020
33
First case of paralytic ileus after endoscopic mucosal resection of caecal polyp. 61
32423855 2020
34
Efficacy of prucalopride in critically ill patients with paralytic ileus: A pilot randomized double-blind placebo-controlled trial. 61
32483847 2020
35
Pathophysiology of Hyperechogenic Bowel in Congenitally Human Cytomegalovirus Infected Fetuses. 61
32455864 2020
36
Meta-analysis of Enhanced Recovery After Surgery (ERAS) Protocols in Emergency Abdominal Surgery. 61
31897698 2020
37
The effect of gum chewing on the return of bowel motility after planned cesarean delivery: a randomized controlled trial. 61
30231787 2020
38
Dapagliflozin-associated euglycemic diabetic ketoacidosis in a patient with type 2 diabetes mellitus: A case report. 61
32481295 2020
39
Systemic lupus erythematosus and hydroxychloroquine-related acute intermittent porphyria. 61
31865445 2020
40
Paralytic ileus as the presenting symptom for Guillain-Barré syndrome: a case report. 61
31875750 2020
41
Recommendations for the diagnosis and treatment of Clostridioides difficile infection: An official clinical practice guideline of the Spanish Society of Chemotherapy (SEQ), Spanish Society of Internal Medicine (SEMI) and the working group of Postoperative Infection of the Spanish Society of Anesthesia and Reanimation (SEDAR). 61
32080996 2020
42
Extended View: Totally Extra Peritoneal (e-TEP) Approach for Ventral and Incisional Hernia-Early results from a single center. 61
32347388 2020
43
Modified Stark's (Misgav Ladach) caesarean section: 15 - year experience of the own techniques of caesarean section. 61
32087422 2020
44
Postoperative paralytic ileus after cytoreductive surgery combined with heated intraperitoneal chemotherapy. 61
32934973 2020
45
Laparoscopic surgery for two patients with strangulated transomental hernias. 61
32189140 2020
46
Delayed Hyponatremia Following Surgery for Pituitary Adenomas: An Under-recognized Complication. 61
32189698 2020
47
Randomized clinical trial of intracorporeal versus extracorporeal anastomosis in laparoscopic right colectomy (IEA trial). 61
31846067 2020
48
Analgesic Effect of Ultrasound-Guided Preoperative Unilateral Lateral Quadratus Lumborum Block for Laparoscopic Nephrectomy: A Randomized, Double-Blinded, Controlled Trial. 61
32753940 2020
49
Influence of peritoneal carcinomatosis on perioperative outcome in palliative gastric bypass for malignant gastric outlet obstruction - a retrospective cohort study. 61
32005250 2020
50
Novel approach to intraoperative peritoneal lavage with an extracorporeal stirring method in laparoscopic surgery for generalized peritonitis: Preliminary results. 61
30672137 2020

Variations for Paralytic Ileus

Expression for Paralytic Ileus

Search GEO for disease gene expression data for Paralytic Ileus.

Pathways for Paralytic Ileus

GO Terms for Paralytic Ileus

Cellular components related to Paralytic Ileus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 VIP TAC1 MLN INS F2 CRP
2 extracellular space GO:0005615 9.23 TAC1 INS GPT F2 CRP AVP

Biological processes related to Paralytic Ileus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.63 VIP TAC1 MLN INS F2 AVP
2 cellular sodium ion homeostasis GO:0006883 9.46 ATP4A ATP12A
3 positive regulation of blood vessel diameter GO:0097755 9.43 VIP INS
4 vasoconstriction GO:0042310 9.4 CRP AVP
5 sodium ion export across plasma membrane GO:0036376 9.37 ATP4A ATP12A
6 cellular potassium ion homeostasis GO:0030007 9.32 ATP4A ATP12A
7 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.26 ATP4A ATP12A
8 positive regulation of cell growth GO:0030307 9.13 INS F2 AVP
9 acute-phase response GO:0006953 8.8 INS F2 CRP

Molecular functions related to Paralytic Ileus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.26 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 9.16 ATP4A ATP12A
3 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP4A ATP12A
4 hormone activity GO:0005179 8.92 VIP MLN INS AVP

Sources for Paralytic Ileus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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