MCID: PRL006
MIFTS: 20

Paralytic Lagophthalmos

Categories: Skin diseases

Aliases & Classifications for Paralytic Lagophthalmos

MalaCards integrated aliases for Paralytic Lagophthalmos:

Name: Paralytic Lagophthalmos 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:12958
ICD9CM 34 374.21
SNOMED-CT 67 193938000
ICD10 32 H02.23
UMLS 70 C0155197

Summaries for Paralytic Lagophthalmos

MalaCards based summary : Paralytic Lagophthalmos is related to lagophthalmos and facial paralysis. An important gene associated with Paralytic Lagophthalmos is NEK8 (NIMA Related Kinase 8). The drug Iron has been mentioned in the context of this disorder. Affiliated tissues include eye and skin.

Related Diseases for Paralytic Lagophthalmos

Diseases related to Paralytic Lagophthalmos via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
# Related Disease Score Top Affiliating Genes
1 lagophthalmos 11.0
2 facial paralysis 10.6
3 keratitis, hereditary 10.4
4 ectropion 10.4
5 keratopathy 10.4
6 yemenite deaf-blind hypopigmentation syndrome 10.4
7 ptosis 10.4
8 neuroma 10.4
9 acoustic neuroma 10.3
10 entropion 10.3
11 exposure keratitis 10.3
12 leprosy 3 10.2
13 conjunctivitis 10.2
14 hansen's disease 10.2
15 autosomal dominant non-syndromic intellectual disability 1 10.0
16 autosomal dominant non-syndromic intellectual disability 2 10.0
17 xerophthalmia 10.0
18 lepromatous leprosy 10.0
19 allergic conjunctivitis 10.0
20 spastic entropion 10.0
21 bell's palsy 10.0
22 keratoconjunctivitis sicca 10.0
23 senile ectropion 10.0
24 corneal ulcer 10.0
25 47,xyy 10.0
26 bap1 tumor predisposition syndrome 10.0
27 hypotonia 10.0
28 neurotrophic keratopathy 10.0

Comorbidity relations with Paralytic Lagophthalmos via Phenotypic Disease Network (PDN):


Facial Paralysis

Graphical network of the top 20 diseases related to Paralytic Lagophthalmos:



Diseases related to Paralytic Lagophthalmos

Symptoms & Phenotypes for Paralytic Lagophthalmos

Drugs & Therapeutics for Paralytic Lagophthalmos

Drugs for Paralytic Lagophthalmos (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved 7439-89-6 23925 29936

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Real-Time Magnetic Device Prototype for Management of Paralytic Lagophthalmos Unknown status NCT03848260

Search NIH Clinical Center for Paralytic Lagophthalmos

Genetic Tests for Paralytic Lagophthalmos

Anatomical Context for Paralytic Lagophthalmos

MalaCards organs/tissues related to Paralytic Lagophthalmos:

40
Eye, Skin

Publications for Paralytic Lagophthalmos

Articles related to Paralytic Lagophthalmos:

(show top 50) (show all 118)
# Title Authors PMID Year
1
Corneal Neurotization in the Setting of Facial Paralysis: A Comprehensive Review of Surgical Techniques. 61
33654040 2021
2
Lipofilling of the upper eyelid to treat paralytic lagophthalmos. 61
32145955 2020
3
Recreation of eyelid mechanics using the sling conceptāœ°. 61
32081580 2020
4
Quality of Life in Patients with Unresolved Facial Nerve Palsy and Exposure Keratopathy Treated by Upper Eyelid Gold Weight Loading. 61
32801632 2020
5
[Biointegration properties of eyelid weight implants made of various materials (experimental study)]. 61
33084275 2020
6
Transitioning from a gold weight to an "enhanced" palpebral spring in the management of paralytic lagophthalmos secondary to facial nerve palsy. 61
30047813 2019
7
Response to Letter: Upper eyelid platinum weight placement for the treatment of paralytic lagophthalmos: A new plane between the inner septum and the levator aponeurosis. 61
30466244 2018
8
Upper eyelid platinum weight placement for the treatment of paralytic lagophthalmos: A new plane between the inner septum and the levator aponeurosis. 61
30466243 2018
9
Septal chondromucosal grafts in paralytic lagophthalmos. 61
30007536 2018
10
Upper eyelid platinum weight placement for the treatment of paralytic lagophthalmos: A new plane between the inner septum and the levator aponeurosis. 61
29788690 2018
11
[Ophthalmic manifestations of facial nerve palsy]. 61
29953091 2018
12
The role of external eyelid weights in acute facial palsy: functional and aesthetic considerations. 61
29383262 2018
13
Simultaneous Surgical Treatment for Smile Dysfunction and Lagophthalmos Involving a Dual Latissimus Dorsi Flap. 61
28831334 2017
14
Application of Palpebral Spring in Asian Patients With Paralytic Lagophthalmos. 61
27564389 2017
15
[Staged complex treatment of paralytic lagophthalmos (case report)]. 61
28291204 2017
16
Vertical-to-Horizontal Rotational Myocutaneous Flap for Repairing Cicatricial Lower Lid Ectropion: A Novel Surgical Technique. 61
29181406 2017
17
[Surgical treatment of purulent corneal ulcers in eyes with neurotrophic keratitis and paralytic lagophthalmos]. 61
29165410 2017
18
Post-septal upper eyelid loading for treatment of exposure keratopathy secondary to non-cicatricial lagophthalmos. 61
27541938 2016
19
Levator lengthening technique using cartilage or fascia graft for paralytic lagophthalmos in facial paralysis. 61
26952126 2016
20
Spontaneous Blinking Kinetics on Paralytic Lagophthalmos After Lid Load with Gold Weight or Autogenous Temporalis Fascia Sling. 61
26016510 2016
21
[Gold weight implants for lagophthalmos correction in chronic facial nerve paralysis (late results)]. 61
27213794 2016
22
Determining Tarsus Curvature in Relation To Direction of Gaze Using Non-contact Ultrasound Video Assistance. 61
27689167 2016
23
Postseptal Weight Placement for Paralytic Lagophthalmos. 61
27408667 2016
24
Paralytic lagophthalmos syndrome in the plastic and maxillofacial surgeon practice. 61
27636764 2016
25
Recession and Extirpation of the Lower Eyelid Retractors for Paralytic Lagophthalmos. 61
26020720 2015
26
Treatment of the periocular complex in paralytic lagophthalmos. 61
25480756 2015
27
[Correction of paralytic lagophthalmos]. 61
26080592 2015
28
[Biointegration of eyelid gold weight implants (experimental study)]. 61
26080590 2015
29
Treatment of migration and extrusion of the gold weight eyelid implant with fascia lata sandwich graft technique. 61
25565227 2015
30
Upper eyelid platinum chain placement for treating paralytic lagophthalmos. 61
25458343 2014
31
Magnetic systems for tarsorrhaphy. 61
24841731 2014
32
Use of hyaluronic acid gel in the treatment of lagophthalmos in sunken superior sulcus syndrome. 61
24614548 2014
33
Modified silicone sling assisted temporalis muscle transfer in the management of lagophthalmos. 61
24618488 2014
34
Upper eyelid postseptal weight placement for treatment of paralytic lagophthalmos. 61
24374701 2014
35
Reply: Upper eyelid postseptal weight placement for treatment of paralytic lagophthalmos. 61
24374702 2014
36
Hyaluronic acid gel weight: a nonsurgical option for the management of paralytic lagophthalmos. 61
24122715 2013
37
[Conceptual basics of paralytic lagophthalmos correction]. 61
24261285 2013
38
Alternative surgical treatment of paralytic lagophthalmos using autogenic cartilage grafts and canthopexy. 61
23728241 2013
39
Upper eyelid postseptal weight placement for treatment of paralytic lagophthalmos. 61
23714789 2013
40
Covering the gold weight with fascia lata graft in paralytic lagophthalmos patients. 61
21680067 2012
41
[The first experience of using an implant for upper eyelid loading in paralytic lagophthalmos]. 61
22741295 2012
42
Correction of paralytic lagophthalmos. 61
22908827 2012
43
Lid loading for treatment of paralytic lagophthalmos. 61
21556983 2011
44
Paul Tessier's technique in the treatment of paralytic lagophthalmos by lengthening of the levator muscle: evaluation of 29 cases. 61
22123547 2011
45
Lower eyelid surgery for lagophthalmos in Möbius and Poland-Möbius syndromes. 61
22134324 2011
46
Surgical treatment of the periocular complex and improvement of quality of life in patients with facial paralysis. 61
21422446 2011
47
Blink lagophthalmos and dry eye keratopathy in patients with non-facial palsy: clinical features and management with upper eyelid loading. 61
21093924 2011
48
Gold weight implantation as a treatment measure for correction of paralytic lagophthalmos. 61
21525707 2011
49
[Surgical treatment options for paralytic lagophthalmos]. 61
21328895 2010
50
Treatment of paralytic lagophthalmos with gold weight implants covered by levator aponeurosis. 61
20489557 2010

Variations for Paralytic Lagophthalmos

Expression for Paralytic Lagophthalmos

Search GEO for disease gene expression data for Paralytic Lagophthalmos.

Pathways for Paralytic Lagophthalmos

GO Terms for Paralytic Lagophthalmos

Cellular components related to Paralytic Lagophthalmos according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell projection GO:0042995 8.62 NEK8 MAPT

Sources for Paralytic Lagophthalmos

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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