MCID: PRL013
MIFTS: 30

Paralytic Poliomyelitis

Categories: Infectious diseases, Muscle diseases, Neuronal diseases, Oral diseases

Aliases & Classifications for Paralytic Poliomyelitis

MalaCards integrated aliases for Paralytic Poliomyelitis:

Name: Paralytic Poliomyelitis 12 15
Poliomyelitis, Paralytic 70

Classifications:



External Ids:

Disease Ontology 12 DOID:0050515
UMLS 70 C1405301

Summaries for Paralytic Poliomyelitis

Disease Ontology : 12 A poliomyelitis that results in destruction located in motor neurons of central nervous system, has material basis in Human poliovirus 1, has material basis in Human poliovirus 2, or has material basis in Human poliovirus 3, which are transmitted by ingestion of food or water contaminated with feces, or transmitted by direct contact with the oral secretions. The infection has symptom loss of reflexes, has symptom muscle spasms, and has symptom acute flaccid paralysis.

MalaCards based summary : Paralytic Poliomyelitis, also known as poliomyelitis, paralytic, is related to bulbar polio and poliomyelitis. An important gene associated with Paralytic Poliomyelitis is PVR (PVR Cell Adhesion Molecule), and among its related pathways/superpathways are NF-kappaB Signaling and Primary immunodeficiency. Affiliated tissues include spinal cord, endothelial and brain, and related phenotypes are Increased Nanog expression and Increased Nanog expression

Wikipedia : 73 Poliomyelitis, commonly shortened to polio, is an infectious disease caused by the poliovirus. In about... more...

Related Diseases for Paralytic Poliomyelitis

Diseases related to Paralytic Poliomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 bulbar polio 31.3 PVR PTBP1 CSDE1
2 poliomyelitis 31.1 PVR IFIH1 EIF4G1 CD4 BTK
3 nonparalytic poliomyelitis 29.4 EIF4G1 DYNLT1 CSDE1
4 spinal polio 11.2
5 bulbospinal polio 11.2
6 agammaglobulinemia 10.4
7 pertussis 10.4
8 diphtheria 10.4
9 tetanus 10.3
10 immune deficiency disease 10.3
11 aseptic meningitis 10.3
12 postpoliomyelitis syndrome 10.3
13 meningitis 10.3
14 common variable immunodeficiency 10.2
15 guillain-barre syndrome 10.2
16 west nile encephalitis 10.1 RNASEL CD4
17 west nile fever 10.1 RNASEL CD4
18 amyotrophic lateral sclerosis 1 10.1
19 myositis 10.1
20 variola major 10.1
21 combined immunodeficiency 10.1
22 mumps 10.1
23 respiratory failure 10.1
24 quadriplegia 10.1
25 lateral sclerosis 10.1
26 myelitis 10.1
27 muscular atrophy 10.1
28 myocarditis 10.1
29 smallpox 10.1
30 pneumocystosis 10.1 CD4 BTK
31 parasitic ectoparasitic infectious disease 10.0 MT-TI CD4
32 central nervous system hematologic cancer 10.0 CD4 BTK
33 plasma protein metabolism disease 10.0 CD4 BTK
34 syringomyelia, noncommunicating isolated 10.0
35 ataxia-telangiectasia 10.0
36 leprosy 3 10.0
37 myasthenia gravis 10.0
38 agammaglobulinemia, x-linked 10.0
39 ataxia and polyneuropathy, adult-onset 10.0
40 west nile virus 10.0
41 tick-borne encephalitis 10.0
42 restless legs syndrome 10.0
43 urinary tract infection 10.0
44 osteomyelitis 10.0
45 bacterial infectious disease 10.0
46 meningoencephalitis 10.0
47 hemiplegia 10.0
48 telangiectasis 10.0
49 diarrhea 10.0
50 facial paralysis 10.0

Graphical network of the top 20 diseases related to Paralytic Poliomyelitis:



Diseases related to Paralytic Poliomyelitis

Symptoms & Phenotypes for Paralytic Poliomyelitis

GenomeRNAi Phenotypes related to Paralytic Poliomyelitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased Nanog expression GR00371-A-1 9.1 NUP153
2 Increased Nanog expression GR00371-A-3 9.1 NUP153 PVR SRSF3
3 Increased Nanog expression GR00371-A-5 9.1 NUP153 PVR

Drugs & Therapeutics for Paralytic Poliomyelitis

Search Clinical Trials , NIH Clinical Center for Paralytic Poliomyelitis

Genetic Tests for Paralytic Poliomyelitis

Anatomical Context for Paralytic Poliomyelitis

MalaCards organs/tissues related to Paralytic Poliomyelitis:

40
Spinal Cord, Endothelial, Brain, Breast, Bone

Publications for Paralytic Poliomyelitis

Articles related to Paralytic Poliomyelitis:

(show top 50) (show all 928)
# Title Authors PMID Year
1
Growing up with a disability following paralytic poliomyelitis: experiences from persons with late effects of polio. 61
31382857 2021
2
The association of online search interest with polio cases and vaccine coverage: an infodemiological and ecological study. 61
33772622 2021
3
Safety and immunogenicity of two novel type 2 oral poliovirus vaccine candidates compared with a monovalent type 2 oral poliovirus vaccine in children and infants: two clinical trials. 61
33308427 2021
4
Mandible reconstruction using a vascularized fibula flap from a post-polio paralytic limb. 61
33358589 2020
5
Essential role of autophagy in restricting poliovirus infection revealed by identification of an ATG7 defect in a poliomyelitis patient. 61
33016799 2020
6
Case of Poliomyelitis Caused by Significantly Diverged Derivative of the Poliovirus Type 3 Vaccine Sabin Strain Circulating in the Orphanage. 61
32883046 2020
7
Environmental Surveillance Complements Case-Based Surveillance of Acute Flaccid Paralysis in Polio Endgame Strategy 2019-2023. 61
32444474 2020
8
Progress Toward Polio Eradication - Worldwide, January 2018-March 2020. 61
32584798 2020
9
Vaccine-Associated Neurological Adverse Events: A Case Report and Literature Review. 61
31742492 2020
10
The experiences of using polio outbreak simulation exercises to strengthen national outbreaks preparedness and response plans in sub-Saharan Africa. 61
33193993 2020
11
A ten-year retrospective evaluation of acute flaccid myelitis at 5 pediatric centers in the United States, 2005-2014. 61
32053652 2020
12
Equivalent schedules of intradermal fractional dose versus intramuscular full dose of inactivated polio vaccine for prevention of poliomyelitis. 61
31858595 2019
13
Update on Vaccine-Derived Poliovirus Outbreaks - Worldwide, January 2018-June 2019. 61
31725706 2019
14
Poliopolis: pushing boundaries of scientific innovations for disease eradication. 61
31482728 2019
15
Recombination in Enteroviruses, a Multi-Step Modular Evolutionary Process. 61
31540135 2019
16
Environmental Surveillance of Polioviruses in Armenia, Colombia before Trivalent Oral Polio Vaccine Cessation. 61
31450757 2019
17
Cold chain and virus-free oral polio booster vaccine made in lettuce chloroplasts confers protection against all three poliovirus serotypes. 61
30575284 2019
18
Postpolio Syndrome: A Review of Lived Experiences of Patients. 61
31392174 2019
19
Prevalence of poliovirus vaccine strains in randomized stool samples from 2010 to 2018: encompassing transition from the trivalent to bivalent oral poliovirus vaccine. 61
31179357 2019
20
Karl Otto Landsteiner (1868-1943). Physician-biochemist-immunologist. 61
27885153 2019
21
Polio vaccination coverage and seroprevalence of poliovirus antibodies after the introduction of inactivated poliovirus vaccines for routine immunization in Japan. 61
30827736 2019
22
Host Genetics, Innate Immune Responses, and Cellular Death Pathways in Poliomyelitis Patients. 61
31354645 2019
23
Post-poliomyelitis syndrome. 61
31496835 2019
24
X-linked agammaglobulinemia (XLA):Phenotype, diagnosis, and therapeutic challenges around the world. 61
30937141 2019
25
Vaccine-associated paralytic poliomyelitis in the Russian Federation in 1998-2014. 61
30201507 2018
26
Development of Thermostable Lyophilized Sabin Inactivated Poliovirus Vaccine. 61
30482835 2018
27
Pediatric HIV Infection and Decreased Prevalence of OPV Point Mutations Linked to Vaccine-associated Paralytic Poliomyelitis. 61
30376083 2018
28
Environmental Surveillance Reveals Complex Enterovirus Circulation Patterns in Human Populations. 61
30377626 2018
29
Immunogenicity of New Primary Immunization Schedules With Inactivated Poliovirus Vaccine and Bivalent Oral Polio Vaccine for the Polio Endgame: A Review. 61
30376081 2018
30
Direct and Indirect Effects on Viral Translation and RNA Replication Are Required for AUF1 Restriction of Enterovirus Infections in Human Cells. 61
30181254 2018
31
On reducing the risk of vaccine-associated paralytic poliomyelitis in the global transition from oral to inactivated poliovirus vaccine. 61
29605427 2018
32
Vaccine-associated paralytic poliomyelitis in a patient with acute lymphocytic leukemia. 61
29322435 2018
33
Strategic Response to an Outbreak of Circulating Vaccine-Derived Poliovirus Type 2 - Syria, 2017-2018. 61
29927908 2018
34
Assessing the stability of polio eradication after the withdrawal of oral polio vaccine. 61
29702638 2018
35
Cuba's Scientific Contributions to Global Polio Eradication. 61
29773776 2018
36
New insights into physiopathology of immunodeficiency-associated vaccine-derived poliovirus infection; systematic review of over 5 decades of data. 61
29478755 2018
37
Recipient vaccine-associated paralytic poliomyelitis in China, 2010-2015. 61
29395524 2018
38
[A case of vaccine-associated paralytic poliomyelitis in an infant]. 61
29863699 2018
39
A novel rat CVB1-VP1 monoclonal antibody 3A6 detects a broad range of enteroviruses. 61
29311608 2018
40
Immunogenicity of sequential inactivated and oral poliovirus vaccines (OPV) versus inactivated poliovirus vaccine (IPV) alone in healthy infants: A systematic review and meta-analysis. 61
29985751 2018
41
Introduction of Inactivated Poliovirus Vaccine and Impact on Vaccine-Associated Paralytic Poliomyelitis - Beijing, China, 2014-2016. 61
29240729 2017
42
The risk of type 2 oral polio vaccine use in post-cessation outbreak response. 61
28974220 2017
43
Pathogenic Events in a Nonhuman Primate Model of Oral Poliovirus Infection Leading to Paralytic Poliomyelitis. 61
28356537 2017
44
Vaccine Associated Paralytic Poliomyelitis Unmasking Common Variable Immunodeficiency. 61
28361789 2017
45
Acute flaccid paralysis laboratorial surveillance in a polio-free country: Brazil, 2005-2014. 61
27901633 2017
46
Cell-Based High-Throughput Screening Assay Identifies 2',2'-Difluoro-2'-deoxycytidine Gemcitabine as a Potential Antipoliovirus Agent. 61
27733043 2017
47
Phase 3 Trial of a Sabin Strain-Based Inactivated Poliovirus Vaccine. 61
27658691 2016
48
[Inactivated poliovirus vaccines: an inevitable choice for eliminating poliomyelitis]. 61
28057103 2016
49
Notice to Readers: Final 2015 Reports of Nationally Notifiable Infectious Diseases and Conditions. 61
27880744 2016
50
Franklin Delano Roosevelt's (FDR's) (1882-1945) 1921 neurological disease revisited; the most likely diagnosis remains Guillain-Barré syndrome. 61
26508622 2016

Variations for Paralytic Poliomyelitis

Expression for Paralytic Poliomyelitis

Search GEO for disease gene expression data for Paralytic Poliomyelitis.

Pathways for Paralytic Poliomyelitis

Pathways related to Paralytic Poliomyelitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.44 RNASEL PVR IFIH1 BTK
2 10.54 CD4 BTK

GO Terms for Paralytic Poliomyelitis

Biological processes related to Paralytic Poliomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral entry into host cell GO:0046718 9.33 PVR NUP153 DYNLT1
2 regulation of translational initiation GO:0006446 9.26 EIF4G1 CSDE1
3 viral process GO:0016032 9.17 TDP2 PVR NUP153 IFIH1 EIF4G1 DYNLT1
4 IRES-dependent viral translational initiation GO:0075522 8.96 PTBP1 CSDE1

Molecular functions related to Paralytic Poliomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA binding GO:0003723 9.43 SRSF3 RNASEL PTBP1 IFIH1 EIF4G1 CSDE1
2 identical protein binding GO:0042802 9.23 RNASEL NUP153 NTSR1 IFIH1 EIF4G1 DYNLT1
3 ribonucleoprotein complex binding GO:0043021 9.16 RNASEL IFIH1

Sources for Paralytic Poliomyelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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